Author: "Soriguer F" / Topic: medicine - Searchworks@Jio Institute Digital Library Search Results

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1. The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study

Author: Raúl López-Izquierdo, Sonsoles Morcillo, Maria L. Mansego, Carmen Ivorra, Juan Carlos Martín-Escudero, Veronica Gonzalez-Albert, Gemma Rojo-Martínez, Josep Redon, Fernando Martinez, Griselda de Marco, F. Javier Chaves, Federico Soriguer, [Mansego,ML, De Marco,G, Ivorra,C, Martínez,F, Redon,J] CIBER Physiopathology of Obesity and Nutrition CIBERobn, CB06/03, Institute of Health Carlos III , Madrid, Spain. [Mansego,ML, González-Albert,V, Chaves,FJ] Genotyping and Genetic Diagnosis Unit, Fundación de Investigación del Hospital Clínico de Valencia-INCLIVA, Valencia, Spain. [De Marco,G, Morcillo,S, Rojo-Martínez,G, Soriguer,F, Chaves,FJ] CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain. [Iborra,C] Cardiovascular Risk Unit, Consorcio, Hospital General, University of Valencia, Valencia, Spain. [Lopez-Izquierdo,R, Martín-Escudero,JC] Internal Medicine Unit, Rio Hortega Hospital, Valladolid, Spain. [Morcillo,S, Soriguer,F] Endocrinology and Nutrition Department, Carlos Haya University Hospital and Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Martinez,F, Rendon,J] Hypertension Clinic, Hospital Clínico Universitario de Valencia, Valencia, Spain., This work was co-funded with European Funds for Regional Development (FEDER), the Spanish Science and Technology Ministry [SAF2005-02883], and the health research fund from the Carlos III Health Institute [PI070497], CIBER Fisiopatología Obesidad y Nutrición (CIBERobn) [CB06/03], and CIBER de Diabetes y Enfermedades Metabólicas Relacionadas (CIBERDEM). CIBEROB and CIBERDEM are initiatives by the Carlos III Health Institute in Madrid and the Spanish Health Ministry. Funding also came from GRUPOS 03/101, PROMETEO/2009/029 and 2005/027, AMP07/075, and ACOMP/2009/201 from the Valencian Government and European Network of Excellence InGenious HyperCare (EPSS-037093) from the European Commission.
Subjects: Male, Antioxidant, Polimorphism, medicine.medical_treatment, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Thioredoxins [Medical Subject Headings], Antioxidantes, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Antioxidants, Vitamin E intake, Obesidad abdominal, chemistry.chemical_compound, Nutrigenomics, Thioredoxins, Polymorphism (computer science), Anatomy::Cells::Blood Cells::Leukocytes [Medical Subject Headings], Risk Factors, Genotype, Vitamin E, Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleosides::Deoxyribonucleosides::Deoxyguanosine [Medical Subject Headings], Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Micronutrients::Vitamins [Medical Subject Headings], Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress [Medical Subject Headings], Abdominal obesity, Nutrigenómica, Medicine(all), Anthropometry, Age Factors, General Medicine, Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity::Obesity, Abdominal [Medical Subject Headings], Middle Aged, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Models [Medical Subject Headings], Waist circumference, Dieta, Female, Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings], medicine.symptom, Factores de riesgo, Vitamin, Adult, medicine.medical_specialty, Vitamina E, Catechol-O-methyltransferase, Biology, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Reporter [Medical Subject Headings], Catechol O-Methyltransferase, Chemicals and Drugs::Biological Factors::Pigments, Biological::Carotenoids::Retinoids::Vitamin A [Medical Subject Headings], Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Sex Factors, Internal medicine, Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Reactive Oxygen Species [Medical Subject Headings], Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Antioxidants [Medical Subject Headings], medicine, Perímetro abdominal, Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Waist Circumference [Medical Subject Headings], Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Benzopyrans::Vitamin E [Medical Subject Headings], Humans, Obesity, Polymorphism, Thioredoxin, Aged, Catechol-O-methyl transferase, Biochemistry, Genetics and Molecular Biology(all), Research, Case-control study, Genes informadores, Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics::Nutrigenomics [Medical Subject Headings], Diet, Oxidative Stress, Endocrinology, chemistry, Spain, Oxidative stress, Case-Control Studies, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::One-Carbon Group Transferases::Methyltransferases::Catechol O-Methyltransferase [Medical Subject Headings], Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA [Medical Subject Headings], Genotipo
Abstract: Background Abdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interaction between antioxidant vitamin intake and OS-related polymorphisms modulates gene-associated anthropometry in a Spanish population. Methods A total of 246 subjects with AO, and 492 age and gender matched non-AO subjects were included in the study. Anthropometric, biochemical, and OS parameters, and antioxidant dietary intake data were assessed using validated procedures. DNA from white blood cells was isolated and the genotype of seven polymorphisms from genes involved in OS (pro-oxidant and antioxidant) were analyzed using the SNPlex system. The effects of the c.-793T > C polymorphism on promoter activity and thus thioredoxin (TXN) activity were examined using reporter assays. Results The AO group had higher 8-Oxo-2′-deoxyguanosine levels and took in less vitamin A and vitamin E compared to the non-AO group. Logistic regression analysis revealed that the rs2301241 polymorphism in TXN and rs740603 in catechol-O-methyltransferase (COMT) were associated with waist circumference (WC) and AO. Moreover, these polymorphisms were more strongly associated with variations in WC in subjects with low vitamin E intakes. A promoter assay revealed that the T to C conversion at c.-793 (rs2301241) induced a more than two fold increase in reporter gene expression. Conclusions WC is associated both with dietary vitamin E intake and genetic variants of TXN and COMT suggesting that existence of a complex nutrigenetic pathway that involves regulation of AO. Electronic supplementary material The online version of this article (doi:10.1186/s12967-015-0652-4) contains supplementary material, which is available to authorized users.
Published: 2015

2. Evaluation of Health-Related Quality of Life according to Carbohydrate Metabolism Status: A Spanish Population-Based Study (Di@bet.es Study)

Author: Rafael Carmena, Inmaculada Mora-Peces, Galder Gutierrez, Juan Girbés, Gemma Pascual-Manich, Federico Soriguer, E. Menéndez, Emilio Ortega, Roger R. Gomis, Elena Bordiú, Sonia Gaztambide, Miguel Catalá, Luis Castaño, Josep Franch, Sergio Valdés, Manuel Fuentes, Gemma Rojo-Martínez, Manuel Serrano-Ríos, Joan Vendrell, Albert Goday, Elías Delgado, Clara Marcuello, Anna Bosch-Comas, Alfonso Calle-Pascual, Roser Casamitjana, María Teresa Martínez-Larrad, J.A. Vázquez, Conxa Castell, Isabelle Runkle, Alfonso López-Alba, [Marcuello,C, Calle-Pascual,AL, Runkle,I] Department of Endocrinology and Nutrition, Hospital Clínico San Carlos de Madrid, Madrid, Spain. [Fuentes,M] Preventive Medicine Service, Hospital Clínico San Carlos de Madrid, Madrid, Spain. [Soriguer,F, Bosch-Comas,A, Carmena,R, Casamitjana,R, Castaño,L, Catalá,M, Gaztambide,S, Gomis,R, Gutiérrez,G, Martínez-Larrad,MT, Ortega,E, Pascual-Manich,G, Rojo-Martínez,G, Serrano-Rios,M, Valdés,S, Vendrell,J] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain. [Soriguer,F, Valdés,S] Department of Endocrinology and Nutrition, Hospital Regional Universitario Carlos Haya Málaga, Málaga, Spain. [Goday,A] Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain. [Bosch-Comas,A, Ortega,E] Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [Bordiú,E] Laboratorio de Endocrinología, Hospital Clínico San Carlos de Madrid, Madrid, Spain. [Carmena,R, Catalá,M] Department of Medicine and Endocrinology, Hospital Clínico Universitario de Valencia, Valencia, Spain. [Casamitjana,R] Biomedic Diagnostic Centre, Hospital Clínic de Barcelona, Barcelona, Spain. [Castaño,L, Gutiérrez,G] Diabetes Research Group, Hospital Universitario de Cruces, UPV-EHU, Barakaldo, Spain. [Castell,C] Public Health Division, Department of Health, Autonomous Government of Catalonia, Barcelona, Spain. [Delgado,E, Menéndez,E] Department of Endocrinology and Nutrition, Hospital Central de Asturias, Oviedo, Spain. [Franch,J] EAP Raval Sud, Institut Català de la Salut, Red GEDAPS, Primary Care, Unitat de Suport a la Recerca (IDIAP—Fundació Jordi Gol), Barcelona, Spain. [Girbés,J] Diabetes Unit, Hospital Arnau de Vilanova, Valencia, Spain. [Gomis,R, Ortega,E] Endocrinology and Diabetes Unit, Hospital Clínic de Barcelona, Universitat de Barcelona (UB), Barcelona, Spain. [López-Alba,A] Spanish Diabetes Society, Madrid, Spain. [Martínez-Larrad,MT, and Serrano-Rios,M] Lipids and Diabetes Laboratory, Hospital Clínico San Carlos de Madrid, Madrid, Spain. [Mora-Peces,I] Canarian Health Service, Tenerife, Spain. [Vázquez,JA] Diabetes National Plan, Ministry of Health, Madrid, Spain. [Vendrell,J] Department of Endocrinology and Nutrition, Hospital Universitario Joan XXIII, Institut d’Investigacions Sanitaries Pere Virgili, Tarragona, Spain.
Subjects: Gerontology, Article Subject, Endocrinology, Diabetes and Metabolism, España, Estudios Transversales, Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings], Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Logistic regression, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Regression Analysis::Logistic Models [Medical Subject Headings], lcsh:Diseases of the endocrine glands. Clinical endocrinology, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus [Medical Subject Headings], Named Groups::Persons::Men [Medical Subject Headings], Endocrinology, Quality of life, Disciplines and Occupations::Social Sciences::Quality of Life [Medical Subject Headings], Diabetes mellitus, Metabolismo de los Hidratos de Carbono, medicine, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Modelos Logísticos, Prediabetes, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Regression Analysis [Medical Subject Headings], Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Sampling Studies [Medical Subject Headings], Análisis de Regresión, Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], lcsh:RC648-665, Endocrine and Autonomic Systems, business.industry, Odds ratio, Anthropometry, medicine.disease, Obesity, Muestreo, humanities, Named Groups::Persons::Women [Medical Subject Headings], Glucosa, Calidad de Vida, business, Body mass index, Phenomena and Processes::Metabolic Phenomena::Metabolism::Carbohydrate Metabolism [Medical Subject Headings], Demography, Research Article
Abstract: Objective. To evaluate the association between diabetes mellitus and health-related quality of life (HRQOL) controlled for several sociodemographic and anthropometric variables, in a representative sample of the Spanish population.Methods. A population-based, cross-sectional, and cluster sampling study, with the entire Spanish population as the target population. Five thousand and forty-seven participants (2162/2885 men/women) answered the HRQOL short form 12-questionnaire (SF-12). The physical (PCS-12) and the mental component summary (MCS-12) scores were assessed. Subjects were divided into four groups according to carbohydrate metabolism status: normal, prediabetes, unknown diabetes (UNKDM), and known diabetes (KDM). Logistic regression analyses were conducted.Results. Mean PCS-12/MCS-12 values were50.9±8.5/47.6±10.2, respectively. Men had higher scores than women in both PCS-12 (51.8±7.2versus50.3±9.2;P<0.001) and MCS-12 (50.2±8.5versus45.5±10.8;P<0.001). Increasing age and obesity were associated with a poorer PCS-12 score. In women lower PCS-12 and MCS-12 scores were associated with a higher level of glucose metabolism abnormality (prediabetes and diabetes), (P<0.0001for trend), but only the PCS-12 score was associated with altered glucose levels in men (P<0.001for trend). The Odds Ratio adjusted for age, body mass index (BMI) and educational level, for a PCS-12 score below the median was 1.62 (CI 95%: 1.2–2.19;P<0.002) for men with KDM and 1.75 for women with KDM (CI 95%: 1.26–2.43;P<0.001), respectively.Conclusion. Current study indicates that increasing levels of altered carbohydrate metabolism are accompanied by a trend towards decreasing quality of life, mainly in women, in a representative sample of Spanish population.
Published: 2012

3. Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population

Author: Fernando Martinez, Sonsoles Morcillo, Juan Carlos Martín-Escudero, Gemma Rojo, María Teresa Martínez-Larrad, Federico Soriguer, Josep Redon, Manuel Serrano-Ríos, Felipe J. Chaves, Maria L. Mansego, Carina Zabena, [Mansego,ML, Chaves,FJ] Genotyping and Genetic Diagnosis Unit, Fundación de Investigación del Hospital Clínico de Valencia-INCLIVA, Valencia, Spain [Martínez,F, Redon,J] Fundación de Investigación del Hospital Clínico de Valencia- INCLIVA, Hypertension Clinic, Hospital Clínico Universitario, University of Valencia, Valencia, Spain. [Martínez-Larrad,MT, Zabena,C, Serrano-Ríos,M] Hospital Clínico San Carlos, Department of Internal Medicine II, Madrid, Spain. [Rojo,G, Morcillo,S, Soriguer,F] Endocrinology and Nutrition Department, Carlos Haya University Hospital, Málaga, Spain. [Martín-Escudero,JC] Internal Medicine department. Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. [Mansego,ML, Chaves,FJ] Centro de Investigación Biomédica en Red (CIBER) de Diabetes y Enfermedades Metabólicas Asociadas ‘‘CIBERDEM’’, Institute of Health Carlos III, Ministry of Health, Madrid, Spain. [Martínez,F, Redon,J] Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología, Obesidad y Nutrición [CIBEROB (CIBER 03/06)], Institute of Health Carlos III, Ministry of Health, Madrid, Spain. [Martínez-Larrad,MT, Serrano-Ríos,M, Rojo,G, Soriguer,F] Centro de Investigación Biomédica en Red (CIBER) de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institute of Health Carlos III, Ministry of Health, Madrid, Spain., Funding: This study was supported by grants SAF2005-02883 from the Interministry Commission of Science and Technology (CICYT), Biomedical Research Centers (CIBER) of Physiopathology, Obesity and Nutrition (CIBEROB), CIBER of Diabetes and Metabolic Diseases (CIBERDEM), Carlos III Health Institute Madrid, the Spanish Health Ministry, GRUPOS 03/101 and 2005/027 from the Valencian Government and European Network of Excellence Ingenious Hypercare (EPSS-037093) from the European Commission, and and Biobank grant from the National Health Institute Carlos III FEDER RD09/0076/00132 (Madrid, Spain). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Subjects: Male, Anatomy and Physiology, España, Diabetes Mellitus Tipo 2, Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Type 2 diabetes, Resistencia a la Insulina, Variación Genética, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genotype::Haplotypes [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Endocrinology, Polymorphism (computer science), Risk Factors, Análisis de Regresión, Factores de Riesgo, Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], Genetics, education.field_of_study, Multidisciplinary, Adulto, Middle Aged, Cardiovascular Diseases, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2 [Medical Subject Headings], Regression Analysis, Medicine, Female, Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Variation [Medical Subject Headings], Fatty Acid Binding Protein 3, Research Article, Adult, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation [Medical Subject Headings], Genotype, Science, Population, Check Tags::Male [Medical Subject Headings], Single-nucleotide polymorphism, Endocrine System, Biology, Fatty Acid-Binding Proteins, Polymorphism, Single Nucleotide, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance [Medical Subject Headings], Insulin resistance, Genetic variation, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], medicine, Humans, Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings], education, Diseases::Cardiovascular Diseases [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles [Medical Subject Headings], Alleles, Aged, Diabetic Endocrinology, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide [Medical Subject Headings], Polymorphism, Genetic, Endocrine Physiology, Haplotype, Genetic Variation, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic [Medical Subject Headings], medicine.disease, Obesity, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Fatty Acid-Binding Proteins [Medical Subject Headings], Check Tags::Female [Medical Subject Headings], Diabetes Mellitus, Type 2, Haplotypes, Spain, Metabolic Disorders, Mutation, Insulin Resistance, Population Genetics
Abstract: Journal Article; Research Support, Non-U.S. Gov't; SUMMARY The main objective was to evaluate the association between SNPs and haplotypes of the FABP1-4 genes and type 2 diabetes, as well as its interaction with fat intake, in one general Spanish population. The association was replicated in a second population in which HOMA index was also evaluated. METHODS 1217 unrelated individuals were selected from a population-based study [Hortega study: 605 women; mean age 54 y; 7.8% with type 2 diabetes]. The replication population included 805 subjects from Segovia, a neighboring region of Spain (446 females; mean age 52 y; 10.3% with type 2 diabetes). DM2 mellitus was defined in a similar way in both studies. Fifteen SNPs previously associated with metabolic traits or with potential influence in the gene expression within the FABP1-4 genes were genotyped with SNPlex and tested. Age, sex and BMI were used as covariates in the logistic regression model. RESULTS One polymorphism (rs2197076) and two haplotypes of the FABP-1 showed a strong association with the risk of DM2 in the original population. This association was further confirmed in the second population as well as in the pooled sample. None of the other analyzed variants in FABP2, FABP3 and FABP4 genes were associated. There was not a formal interaction between rs2197076 and fat intake. A significant association between the rs2197076 and the haplotypes of the FABP1 and HOMA-IR was also present in the replication population. CONCLUSIONS The study supports the role of common variants of the FABP-1 gene in the development of type 2 diabetes in Caucasians. Yes
Published: 2011

4. Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects

Author: Stella González-Romero, Isabel Cardona, Marta Vilaró Pacheco, Carolina Gutiérrez-Repiso, M. J. Garriga, Inés Velasco, Elehazara Rubio-Martín, Eduardo García-Fuentes, Jaime López-Ojeda, Francisca Linares, Piedad Santiago, Federico Soriguer, [Soriguer,F, González-Romero,S, García-Fuentes,E] Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Soriguer,F, Rubio-Martin,E] CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Málaga, Spain. [Gutiérrez-Repiso,C, Linares,F, Cardona,I, García-Fuentes,E] Fundación IMABIS, Málaga, Spain. [López-Ojeda,J, Pacheco, M] Servicio de Radiología, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Garriga, MJ] Servicio de Análisis Clínicos, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Velasco,I] Servicio de Obstetricia y Ginecología, Hospital de Riotinto, Huelva, Spain. [Santiago,P] Servicio de Endocrinología y Nutrición, Hospital General, Jaen, Spain. [García-Fuentes,E] CIBER Fisiopaptología de la Obesidad y Nutrición (CIBERobn), Málaga, Spain. Laboratorio de Investigación, Málaga, Spain., and The present study was supported in part by grants from the Instituto de Salud Carlos III (CP04/00133). CIBER FisiopatologÍa de la Obesidad y NutriciÓn (CIBEROBN) and CIBER de Diabetes y Enfermedades MetabÓlicas Asociadas (CIBERDEM)are ISCIII projects.
Subjects: Male, Iodide, Thyroid Gland, Medicine (miscellaneous), Urine, Antioxidants, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants [Medical Subject Headings], Proteínas de fase aguda, Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress [Medical Subject Headings], Mujeres Embarazadas, chemistry.chemical_classification, education.field_of_study, Nutrition and Dietetics, Adulto, Marcadores biológicos, Chemistry, Glutathione peroxidase, Urinary iodine, Female, Thyroid function, Iodine, Chemicals and Drugs::Inorganic Chemicals::Elements::Halogens::Iodine [Medical Subject Headings], Adult, medicine.medical_specialty, Thyroid Hormones, Population, chemistry.chemical_element, Internal medicine, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Chemicals and Drugs::Biological Factors::Biological Markers [Medical Subject Headings], medicine, Humans, education, Inflammation, Named Groups::Persons::Women::Pregnant Women [Medical Subject Headings], Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Acute-Phase Proteins [Medical Subject Headings], Analysis of Variance, Inflamación, medicine.disease, Iodine deficiency, Oxidative Stress, Endocrinology, Dietary Supplements, Lipid Peroxidation, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings], Biomarkers, Estrés Oxidativo, Hormone, Acute-Phase Proteins
Abstract: Little information is available as to whether doses of iodide similar to those recommended in clinical practice for the prevention of iodine deficiency in pregnant women affect thyroid function. The aim of the present study was to analyse whether doses of iodide can affect thyroid function in adults, and evaluate its effect on plasma markers of oxidative stress, inflammation and acute-phase proteins. A total of thirty healthy volunteers (ten men and twenty women) with normal thyroid function were randomly assigned to three groups (n10). Each group received a daily dose of 100, 200 or 300 μg of iodide in the form of KI for 6 months. Free tetraiodothyronine (FT4) levels at day 60 of the study were higher in the groups treated with 200 and 300 μg (P = 0·01), and correlated with the increase in urinary iodine (r0·50,P = 0·007). This correlation lost its significance after adjustment for the baseline FT4. The baseline urinary iodine and FT4 correlated positively with the baseline glutathione peroxidase. On day 60, urinary iodine correlated with C-reactive protein (r0·461,P = 0·018), and free triiodothyronine correlated with IL-6 (r− 0·429,P = 0·025). On day 60, the changes produced in urinary iodine correlated significantly with the changes produced in α1-antitrypsin (r0·475,P = 0·014) and ceruloplasmin (r0·599,P = 0·001). The changes in thyroid-stimulating hormone correlated significantly with the changes in α1-antitrypsin (r− 0·521,P = 0·005) and ceruloplasmin (r− 0·459,P = 0·016). In conclusion, the administration of an iodide supplement between 100 and 300 μg/d did not modify thyroid function in a population with adequate iodine intake. The results also showed a slight anti-inflammatory and antioxidative action of iodide.
Published: 2011

5. ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism

Author: Gracia María Martín-Núñez, Eva García-Escobar, Sonsoles Morcillo, Felipe J. Chaves, Griselda de Marco, Federico Soriguer, María Cruz Almaraz, Maria L. Mansego, Gemma Rojo-Martínez, [Morcillo,S, Martín Núñez,GM, Rojo Martínez,G, Almaraz,MC, García Escobar,E, Soriguer,F] Endocrinology and Nutrition Service, Hospital Carlos Haya, Málaga, Spain.[Morcillo,S, Mansego,ML, de Marco,G, Chaves,FJ, Soriguer,F] CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) of the Instituto de Salud Carlos III, Barcelona, Spain. [Mansego,ML, Chaves,FJ] Unidad de Genotipado y Diagnóstico Genético, Hospital Clinic Research Foundation Valencia-INCLIVA, Valencia, Spain., and This study was funded by the Fondo de Investigación Sanitaria (PI051307, PI09/2117, and PI070497), Junta de AndalucÃa (PI0192/2008) and CIBERDEM (INGENFRED Project CB-02/08/2009).
Subjects: Male, Candidate gene, Anatomy and Physiology, Epidemiology, medicine.medical_treatment, Resistencia a la Insulina, Endocrinology, Insulin, Prospective Studies, Genetics, education.field_of_study, Multidisciplinary, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Acyltransferases::Acetyltransferases [Medical Subject Headings], Estudios Prospectivos, Middle Aged, Genetic Epidemiology, Medicine, Female, Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings], Research Article, Adult, Acetiltransferasas, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], Adolescent, Genotype, Fatty Acid Elongases, Science, Population, Single-nucleotide polymorphism, Endocrine System, Biology, Polymorphism, Single Nucleotide, Young Adult, Insulin resistance, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance [Medical Subject Headings], Acetyltransferases, Genetic variation, medicine, Humans, Obesity, Allele, education, Genetic Association Studies, Aged, Nutrition, Diabetic Endocrinology, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide [Medical Subject Headings], Endocrine Physiology, Metabolismo Energético, Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism [Medical Subject Headings], Human Genetics, Diabetes Mellitus Type 2, medicine.disease, Minor allele frequency, Metabolic Disorders, Genetics of Disease, Genetic Polymorphism, Polimorfismo de Nucleótido Simple, Insulin Resistance, Energy Metabolism, Physiological Processes, Genotipo, Population Genetics
Abstract: BackgroundThe elongase of long chain fatty acids family 6 (ELOVL6) is an enzyme that specifically catalyzes the elongation of saturated and monounsaturated fatty acids with 12, 14 and 16 carbons. ELOVL6 is expressed in lipogenic tissues and it is regulated by sterol regulatory element binding protein 1 (SREBP-1).ObjectiveWe investigated whether ELOVL6 genetic variation is associated with insulin sensitivity in a population from southern Spain.DesignWe undertook a prospective, population-based study collecting phenotypic, metabolic, nutritional and genetic information. Measurements were made of weight and height and the body mass index (BMI) was calculated. Insulin resistance was measured by homeostasis model assessment. The type of dietary fat was assessed from samples of cooking oil taken from the participants' kitchens and analyzed by gas chromatography. Five SNPs of the ELOVL6 gene were analyzed by SNPlex.ResultsCarriers of the minor alleles of the SNPs rs9997926 and rs6824447 had a lower risk of having high HOMA_IR, whereas carriers of the minor allele rs17041272 had a higher risk of being insulin resistant. An interaction was detected between the rs6824447 polymorphism and the intake of oil in relation with insulin resistance, such that carriers of this minor allele who consumed sunflower oil had lower HOMA_IR than those who did not have this allele (P = 0.001).ConclusionsGenetic variations in the ELOVL6 gene were associated with insulin sensitivity in this population-based study.
Published: 2010

6. Intake and home use of olive oil or mixed oils in relation to healthy lifestyles in a Mediterranean population. Findings from the prospective Pizarra study

Author: Sergio Valdés, Jose Manuel García-Almeida, M. Cruz Almaraz, Gemma Rojo-Martínez, Isabel Esteva, Sonsoles Morcillo, Isabel Cardona, Gabriel Olveira, Francisca Linares, M. Carmen Dobarganes, M. Soledad Ruiz-de-Adana, Virginia Hernando, Eva García-Escobar, Federico Soriguer, [Soriguer, F, Almaraz, MC, García-Almeida, JM, Cardona, I, Linares, F, Morcillo, S, García-Escobar, E, Olveira, G, Hernando, V, Valdes, S, Ruiz-de-Adana, MS, Esteva, I, Rojo-Martínez, G]Servicio de Endocrinología y nutrición, Hospital Universitario Carlos Haya, Malaga,Spain. [Soriguer, F, Ruiz-de-Adana ,MS, Rojo-Martínez, G] CIBER Diabetes and Metabolism (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Alicante, Spain. [Soriguer, F, Rojo-Martínez, G] CIBER Physiology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Dobarganes, MC] Instituto de la Grasa, CSIC, Seville, Spain., and The present study was supported by Fondo de Investigación Sanitaria (PI041883, PI051307), Junta de Andalucía (0124/2005, P06-CTS-01 684)and Fundación Centro de Excelencia en Investigación sobre Aceite de oliva y Salud (CEAS).
Subjects: Mediterranean climate, Male, Geographicals::Geographic Locations::Europe::Mediterranean Region::Mediterranean Islands [Medical Subject Headings], Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Data Collection::Questionnaires [Medical Subject Headings], Health Status, humanos, España, Medicine (miscellaneous), Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Índice de masa corporal, Adulto joven, Health Care::Population Characteristics::Demography::Health Status [Medical Subject Headings], masculino, Body Mass Index, Aceites de plantas, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Nutrient, Grasas dietéticas insaturadas, Surveys and Questionnaires, Estudios prospectivos, Medicine, Fosfolípidos, Chemicals and Drugs::Lipids::Fats::Dietary Fats::Dietary Fats, Unsaturated [Medical Subject Headings], Food science, Prospective Studies, Cuestionarios, Prospective cohort study, Phospholipids, Adolescente, Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], education.field_of_study, Nutrition and Dietetics, Adulto, Ingestión de energía, Femenino, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::Food Habits [Medical Subject Headings], Middle Aged, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Energy Intake [Medical Subject Headings], Hábitos alimenticios, Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings], Estado de salud, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Prospective Studies [Medical Subject Headings], Composition (visual arts), Female, Adult, food.ingredient, Adolescent, Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings], Deep frying, Population, Anciano, Check Tags::Male [Medical Subject Headings], Islas del Mediterráneo, Estilo de vida, Chemicals and Drugs::Lipids::Fats::Dietary Fats [Medical Subject Headings], Mediterranean Islands, Young Adult, food, Dietary Fats, Unsaturated, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Humans, Plant Oils, MUFA, Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings], education, Chemicals and Drugs::Lipids::Phospholipids [Medical Subject Headings], Life Style, Aged, Mediana edad, business.industry, Sunflower oil, Frying oil, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology, Social::Life Style [Medical Subject Headings], Feeding Behavior, Lifestyle, Dietary Fats, Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Biometry::Anthropometry::Body Mass Index [Medical Subject Headings], Check Tags::Female [Medical Subject Headings], Spain, Grasas dietéticas, Chemicals and Drugs::Lipids::Oils::Plant Oils [Medical Subject Headings], business, Energy Intake, Body mass index, Olive oil
Abstract: Discordances exist in epidemiological studies regarding the association between the intake of nutrients and death and disease. We evaluated the social and health profile of persons who consumed olive oil in a prospective population cohort investigation (Pizarra study) with a 6-year follow-up. A food frequency questionnaire and a 7d quantitative questionnaire were administered to 538 persons. The type of oil used in food preparation was determined by direct measurement of the fatty acids in samples obtained from the kitchens of the participants at baseline and after follow-up for 6 years. The fatty acid composition of the serum phospholipids was used as an endogenous marker of the type of oil consumed. Total fat intake accounted for a mean 40% of the energy (at baseline and after follow-up). The concordance in intake of MUFA over the study period was high. The fatty acid composition of the serum phospholipids was significantly associated with the type of oil consumed and with fish intake. The concentration of polar compounds and polymers, indicative of degradation, was greater in oils from the kitchens where sunflower oil or refined olive oil was used, in oils used for deep frying and in oils that had been reused for frying five times or more. Consumption of olive oil was directly associated with educational level. Part of the discordance found in epidemiological studies between diet and health may be due to the handling of oils during food preparation. The intake of olive oil is associated with other healthy habits. © 2009 The Authors., The present study was supported by Fondo de Investigación Sanitaria (PI041883, PI051307), Junta de Andalucía (0124/2005, P06-CTS-01 684) and Fundación Centro de Excelencia en Investigación sobre Aceite de oliva y Salud (CEAS). CIBERDEM and CIBEROBN are initiatives of Instituto de Salud Carlos III, Spain.
Published: 2010

7. Amniotic fluid iodine concentrations do not vary in pregnant women with varying iodine intake

Author: Inés Velasco, Federico Soriguer, Piedad Santiago, Manuel Gallo, Eduardo García-Fuentes, Stephanie Prieto, Laureano García, Javier Alcaide-Torres, [García-Fuentes,E, Prieto,S, Soriguer,F] Servicio de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Málaga, Spain. [Gallo,M, García,L, Alcaide-Torres,J] Unidad de Medicina Foetal, Departamento de Obstetricia y Ginecología, Hospital Universitario Carlos Haya, Málaga, Spain. [García-Fuentes,E, Prieto,S] Fundación IMABIS, Málaga, Spain. [García-Fuentes,E] Ciber Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III, Spain. [Soriguer,F] Ciber Diabetes y Enfermedades Metabolicas (CB07/08), Instituto de Salud Carlos III, Spain. [Santiago,P] Servicio de Endocrinología y Nutrición, Hospital de Jaén, Jaén, Spain. [Velasco,I] Servicio de Obstetricia y Ginecología, Hospital de Osuna, Sevilla, Spain., and The research group belongs to the Physiopathology of Obesity and Nutrition CIBER (CB06/03/0018) and Ciber Diabetes y Enfermedades Metabolicas (CB07/08) of the Instituto de Salud Carlos III. This work was supported in part by a grant from Recordati.
Subjects: Yoduro potásico, Amniotic fluid, Medicine (miscellaneous), Urine, Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Technology, Industry, Agriculture::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings], Pregnancy, Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Pregnancy Trimesters::Pregnancy Trimester, Second [Medical Subject Headings], Medicine, Chemicals and Drugs::Inorganic Chemicals::Sodium Compounds::Sodium Chloride::Sodium Chloride, Dietary [Medical Subject Headings], Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutritional Status [Medical Subject Headings], Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Micronutrients::Vitamins [Medical Subject Headings], Estado Nutricional, Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings], Nutrition and Dietetics, medicine.diagnostic_test, Obstetrics, Vitamins, Middle Aged, Iodised salt, Anatomy::Fluids and Secretions::Amniotic Fluid [Medical Subject Headings], Dietary Reference Intake, Pregnancy Trimester, Second, Yodo, Amniocentesis, Female, Multivitamin, Iodine, Adult, Chemicals and Drugs::Inorganic Chemicals::Elements::Halogens::Iodine [Medical Subject Headings], medicine.medical_specialty, Líquido amniótico, Embarazo, Suplementos Dietéticos, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Obstetrical and Gynecological::Prenatal Diagnosis::Amniocentesis [Medical Subject Headings], Nutritional Status, chemistry.chemical_element, Statistics, Nonparametric, Cloruro sódico dietético, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Humans, Sodium Chloride, Dietary, Chemicals and Drugs::Inorganic Chemicals::Iodine Compounds::Iodides::Potassium Iodide [Medical Subject Headings], business.industry, Potassium Iodide, Amniotic Fluid, medicine.disease, Iodine deficiency, chemistry, Check Tags::Female [Medical Subject Headings], Dietary Supplements, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Statistics, Nonparametric [Medical Subject Headings], business
Abstract: Iodine deficiency is an important clinical and public health problem. Its prevention begins with an adequate intake of iodine during pregnancy. International agencies recommend at least 200 μg iodine per d for pregnant women. We assessed whether iodine concentrations in the amniotic fluid of healthy pregnant women are independent of iodine intake. This cross-sectional, non-interventional study included 365 consecutive women who underwent amniocentesis to determine the fetal karyotype. The amniocentesis was performed with abdominal antisepsis using chlorhexidine. The iodine concentration was measured in urine and amniotic fluid. The study variables were the intake of iodized salt and multivitamin supplements or the prescription of a KI supplement. The mean level of urinary iodine was 139·0 (sd94·5) μg/l and of amniotic fluid 15·81 (sd7·09) μg/l. The women who consumed iodized salt and those who took a KI supplement had significantly higher levels of urinary iodine than those who did not (P = 0·01 andP = 0·004, respectively). The urinary iodine levels were not significantly different in the women who took a multivitamin supplement compared with those who did not take this supplement, independently of iodine concentration or multivitamin supplement. The concentrations of iodine in the amniotic fluid were similar, independent of the dietary iodine intake. Urine and amniotic fluid iodine concentrations were weakly correlated, although the amniotic fluid values were no higher in those women taking a KI supplement. KI prescription at recommended doses increases the iodine levels in the mother without influencing the iodine levels in the amniotic fluid.
Published: 2008

8. Inverse relation between levels of anti-oxidized-LDL antibodies and eicosapentanoic acid (EPA)

Author: Lourdes Garrido-Sánchez, Eduardo García-Fuentes, Federico Soriguer, Fernando Cardona, Gemma Rojo-Martínez, Francisco J. Tinahones, [Garrido-Sánchez,L, García-Fuentes,E, Cardona,F, Tinahones Madueño,FJ] Ciber Fisiopatología, Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III, Spain. [Tinahones Madueño,FJ] Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [García-Fuentes,E, Rojo-Martínez,G, Cardona,F] Fundación IMABIS (Instituto Mediterráneo para el Avance de la Biotecnología y la Investigación Sanitaria), Málaga, Spain. [Rojo-Martínez,G, Soriguer,F] Ciber Diabetes y Enfermedades metabólicas (CB07/08/0019), Instituto de salud Carlos III, Spain. [Soriguer,F] Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya, Málaga, Spain., and The research group belongs to the Physiopathology of Obesity and Nutrition CIBER (CB06/03/0018), CIBER Diabetes y Enfermedades metabólicas (CB07/08/0019) of the Instituto de Salud Carlos III and FIS G03/152.
Subjects: Antioxidant, medicine.medical_treatment, Medicine (miscellaneous), Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Chemicals and Drugs::Lipids::Fats::Dietary Fats::Dietary Fats, Unsaturated::Fatty Acids, Omega-3::Eicosapentaenoic Acid [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], chemistry.chemical_compound, Fosfolípidos, Phospholipids, Aterosclerosis, chemistry.chemical_classification, Análisis de Regresión, Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDL [Medical Subject Headings], Nutrition and Dietetics, biology, Chemistry, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Age Factors [Medical Subject Headings], Fatty Acids, Age Factors, Lipoproteínas LDL, Eicosapentanoic acid, Autoanticuerpos, Chemicals and Drugs::Lipids::Fatty Acids [Medical Subject Headings], Middle Aged, Lipoproteins, LDL, Factores de edad, Eicosapentaenoic Acid, Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings], Fatty Acids, Unsaturated, Regression Analysis, Female, lipids (amino acids, peptides, and proteins), Antibody, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies [Medical Subject Headings], Polyunsaturated fatty acid, Adult, Oxidized LDL, medicine.medical_specialty, Anticuerpos, Adolescent, Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings], Oxidative phosphorylation, Antibodies, Ácido Eicosapentaenoico, Young Adult, Internal medicine, medicine, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Humans, Ácidos Grasos, Fatty acids, Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Chemicals and Drugs::Lipids::Phospholipids [Medical Subject Headings], Aged, Autoantibodies, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis [Medical Subject Headings], Cholesterol, Ácidos Grasos Insaturados, Fatty acid, Atherosclerosis, Endocrinology, Check Tags::Female [Medical Subject Headings], Immunology, biology.protein, oxidized low density lipoprotein, Oxidized ldl, Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated [Medical Subject Headings]
Abstract: Journal Article; Research Support, Non-U.S. Gov't; Oxidative modification of LDL is thought to play an important role in the development of atherosclerosis. Susceptibility of LDL to peroxidation may partly depend on the compositional characteristics of the antioxidant and fatty acid content. The aim of this study was to examine the association between levels of antibodies to oxidized LDL and the various serum fatty acids in women. A total of 465 women aged 18-65 years were selected randomly from the adult population census of Pizarra, a town in southern Spain. Measurement of anti-oxidized-LDL was done by ELISA and the fatty acid composition of serum phospholipids was determined by GC. The levels of anti-oxidized-LDL antibodies were significantly related with age (r - 0.341, P < 0.001), BMI (r - 0.239, P < 0.001), waist:hip ratio (r - 0.285, P < 0.001), glucose (r - 0.208, P < 0.001), cholesterol (r - 0.243, P < 0.001), LDL-cholesterol (r - 0.185, P = 0.002), EPA (r - 0.159, P = 0.003), DHA (r - 0.121, P = 0.026), and the sum of the serum phospholipid n-3 PUFA (r - 0.141, P = 0.009). Multiple regression analysis showed that the variables that explained the behaviour of the levels of anti-oxidized-LDL antibodies were age (P < 0.001) and the serum phospholipid EPA (P < 0.001). This study showed that the fatty acid composition of serum phospholipids, and especially the percentage of EPA, was inversely related with the levels of anti-oxidized-LDL antibodies. Yes
Published: 2008

9. Epigenetic Biomarkers of Transition from Metabolically Healthy Obesity to Metabolically Unhealthy Obesity Phenotype: A Prospective Study

Author: Sergio Valdés, Francisco J. Tinahones, Andres Gonzalez-Jimenez, Francisca Aguilar-Lineros, Teresa María Linares-Pineda, Sonsoles Morcillo, Gemma Rojo-Martínez, Federico Soriguer, Carolina Gutiérrez-Repiso, [Gutiérrez-Repiso,C, Linares-Pineda,TM, Aguilar-Lineros,F, Tinahones,FJ, Morcillo,S] Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Gutiérrez-Repiso,C, Morcillo,S] Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain. [Gonzalez-Jimenez,A] ECAI Bioinformática Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Valdés,S, Soriguer,F, Rojo-Martínez,G] Departamento de Endocrinología and Nutrición, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Valdés,S, Rojo-Martínez,G] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain. [Tinahones,FJ] Departamento de Medicina y Dermatología, Universidad de Málaga, Málaga, Spain., and T.M.L.-P. and C.G.-R. were supported by a grant from the Instituto de Salud Carlos III (FI19/00178 and CP20/00066, respectively). F.A.-L. is supported by a grant from 'Programa Estatal de Promoción del Talento y su empleabilidad 2018' (PEJ2018-005156-A). S.M. and G.R.-M. are supported by Nicolas Monardes program of the Consejería de Salud de la Junta de Andalucía (C 0050-2017, C-0060-2012, respectively). This work was supported in part by a grant from the Instituto de Salud Carlos III (PI15-01350). This study has been co-funded by FEDER funds ('A way to make Europe'). CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) are ISCIII projects.
Subjects: Male, Síndrome metabólico, Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings], epigenetic biomarkers, Epigenesis, Genetic, Epigenetic biomarkers, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigens::HLA-DR beta-Chains::HLA-DRB1 Chains [Medical Subject Headings], Metabolically healthy obesity, Prospective Studies, Biology (General), Spectroscopy, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Pseudogenes [Medical Subject Headings], Phenomena and Processes::Metabolic Phenomena::Metabolism::Alkylation::Methylation::DNA Methylation [Medical Subject Headings], DNA methylation, biology, SLC1A1, General Medicine, Methylation, Middle Aged, Phenotype, Metabolic syndrome, Computer Science Applications, Chemistry, CpG site, Female, metabolically healthy obesity, Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, Pharmacological [Medical Subject Headings], Metilación de ADN, Adult, Adolescent, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], QH301-705.5, Check Tags::Male [Medical Subject Headings], Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Base Sequence::GC Rich Sequence::CpG Islands [Medical Subject Headings], Catalysis, Article, Phenomena and Processes::Immune System Phenomena::Immune System Processes::Antigen Presentation [Medical Subject Headings], metabolic syndrome, Persons::Persons::Age Groups::Adolescent [Medical Subject Headings], Inorganic Chemistry, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings], Persons::Persons::Volunteers::Healthy Volunteers [Medical Subject Headings], medicine, Humans, Epigenetics, Obesity, Physical and Theoretical Chemistry, Obesidad metabólica benigna, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Molecular Biology, QD1-999, Aged, Chemicals and Drugs::Enzymes and Coenzymes::Cytochromes::Cytochrome P-450 Enzyme System::Aryl Hydrocarbon Hydroxylases::Cytochrome P-450 CYP2E1 [Medical Subject Headings], Organic Chemistry, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic [Medical Subject Headings], Anatomy::Hemic and Immune Systems::Immune System [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], medicine.disease, Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [Medical Subject Headings], Immune system, Biomarcadores, Sistema inmunológico, Check Tags::Female [Medical Subject Headings], Immunology, biology.protein, CpG Islands, Biomarkers, Follow-Up Studies
Abstract: Background: Identifying those parameters that could potentially predict the deterioration of metabolically healthy phenotype is a matter of debate. In this field, epigenetics, in particular DNA methylation deserves special attention. Results: The aim of the present study was to analyze the long-term evolution of methylation patterns in a subset of metabolically healthy subjects in order to search for epigenetic markers that could predict the progression to an unhealthy state. Twenty-six CpG sites were significantly differentially methylated, both at baseline and 11-year follow-up. These sites were related to 19 genes or pseudogenes, a more in-depth analysis of the methylation sites of these genes showed that CYP2E1 had 50% of the collected CpG sites differently methylated between stable metabolically healthy obesity (MHO) and unstable MHO, followed by HLA-DRB1 (33%), ZBTB45 (16%), HOOK3 (14%), PLCZ1 (14%), SLC1A1 (12%), MUC2 (12%), ZFPM2 (12.5%) and HLA-DQB2 (8%). Pathway analysis of the selected 26 CpG sites showed enrichment in pathways linked to th1 and th2 activation, antigen presentation, allograft rejection signals and metabolic processes. Higher methylation levels in the cg20707527 (ZFPM2) could have a protective effect against the progression to unstable MHO (OR: 0.21, 95%CI (0.067–0.667), p &lt, 0.0001), whilst higher methylation levels in cg11445109 (CYP2E1) would increase the progression to MUO, OR: 2.72, 95%CI (1.094–6.796), p &lt, 0.0014, respectively). Conclusions: DNA methylation status is associated with the stability/worsening of MHO phenotype. Two potential biomarkers of the transition to an unhealthy state were identified and deserve further investigation (cg20707527 and cg11445109). Moreover, the described differences in methylation could alter immune system-related pathways, highlighting these pathways as therapeutic targets to prevent metabolic deterioration in MHO patients.
Published: 2021
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10. Low physical activity and its association with diabetes and other cardiovascular risk factors: a nationwide, population-based study

Author: Sonia Gaztambide, Edelmiro Menéndez, Gemma Pascual-Manich, Federico Soriguer, Anna Bosch-Comas, Rafael Carmena, Ramon Gomis, Inmaculada Mora-Peces, Albert Goday, Miguel Catalá, Laura Brugnara, María Teresa Martínez-Larrad, Anna Novials, Joan Vendrell, Emilio Ortega, Josep Franch, Alfonso L. Calle-Pascual, Serafín Murillo, Juan Girbés, Roser Casamitjana, Alfonso López-Alba, Manuel Serrano-Ríos, Elena Bordiú, Gemma Rojo-Martínez, Luis Castaño, Sergio Valdés, Elías Delgado, Conxa Castell, Universitat de Barcelona, [Brugnara,L, Murillo,S, Novials,A, Rojo-Martínez,G, Soriguer,F, Castaño,L, Gaztambide,S, Valdés,S, Vendrell,J, Casamitjana,R, Boch-Comas,A, Carmena,R, Catalá,M, Martínez-Larrad,MT, Pascual-Manich,G, Serrano-Rios,M, Gomis,R] CIBERDEM—Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Madrid, Spain. [Brugnara,L, Bosch-Comas,A, Gomis,R] IDIBAPS—August Pi i Sunyer Biomedical Research Institute / Hospital Clínic de Barcelona, Barcelona, Spain. [Rojo-Martínez,G, Valdés,S] Hospital Universitario Carlos Haya, Department of Endocrinology and Nutrition, Málaga, Spain. [Goday,A] Hospital del Mar, Department of Endocrinology and Nutrition, Barcelona, Spain. [Calle-Pascual,A, Bordiú,E] Hospital Universitario San Carlos, Madrid, Spain. [Gaztambide,S] Hospital Universitario de Cruces, UPV-EHU, Diabetes Research Group, Baracaldo, Spain. [Franch,J] EAP Raval Sud, Institut Català de la Salut, Red GEDAPS, IDIAP, Barcelona, Spain. [Castell,C] Public Health Division, Autonomous Government of Catalonia, Barcelona, Spain. [Vendrell,J] Department of Endocrinology and Nutrition, Hospital Universitario Joan XXIII, Tarragona, Spain. [Carmena,R, Catalá,M] Department of Medicine and Endocrinology, Hospital Clínico Universitario de Valencia, Valencia, Spain. [Delgado,E, Menéndez,E] Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Oviedo, Spain. [Gilbés,J] Hospital Arnau de Vilanova, Valencia, Spain. [López-Alba,A] Fundación Hospital de Jove, Gijón, Spain. [Serrano-Ríos,M] Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Mora-Peces,I] Canarian Health Service, San Cristóbal de la Laguna, Tenerife, Spain. [Martínez-Larraz,MT, Ortega,E] CIBEROBN - Spanish Biomedical Research Centre in Physiopathology of Obesity. [Ortega,E] Department of Endocrinology and Nutrition, ICMDM, Hospital Clinic Barcelona., This work was supported by the Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM, ISCIII Ministerio de Ciencia e Innovación), Ministerio de Sanidad y Consumo and the Spanish Diabetes Society (SED)., [Brugnara, Laura] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Murillo, Serafin] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Novials, Anna] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Rojo-Martinez, Gemma] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Soriguer, Federico] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Castano, Luis] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Gaztambide, Sonia] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Valdes, Sergio] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Vendrell, Joan] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Casamitjana, Roser] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Bosch-Comas, Anna] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Carmena, Rafael] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Catala, Miguel] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Teresa Martinez-Larrad, Maria] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Pascual-Manich, Gemma] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Serrano-Rios, Manuel] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Gomis, Ramon] CIBERDEM Spanish Biomed Res Ctr Diabet & Associat, Madrid, Spain, [Brugnara, Laura] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Murillo, Serafin] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Novials, Anna] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Casamitjana, Roser] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Bosch-Comas, Anna] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Pascual-Manich, Gemma] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Gomis, Ramon] Hosp Clin Barcelona, IDIBAPS August Pi & Sunyer Biomed Res Inst, Barcelona, Spain, [Rojo-Martinez, Gemma] Hosp Univ Carlos Haya, Dept Endocrinol & Nutr, Malaga, Spain, [Soriguer, Federico] Hosp Univ Carlos Haya, Dept Endocrinol & Nutr, Malaga, Spain, [Valdes, Sergio] Hosp Univ Carlos Haya, Dept Endocrinol & Nutr, Malaga, Spain, [Goday, Albert] Hosp Mar, Dept Endocrinol & Nutr, Barcelona, Spain, [Calle-Pascual, Alfonso] Hosp Univ San Carlos, Madrid, Spain, [Bordiu, Elena] Hosp Univ San Carlos, Madrid, Spain, [Castano, Luis] Univ Basque Country, Hosp Univ Cruces, Diabet Res Grp, Baracaldo, Spain, [Gaztambide, Sonia] Univ Basque Country, Hosp Univ Cruces, Diabet Res Grp, Baracaldo, Spain, [Franch, Josep] IDIAP, Red GEDAPS, Inst Catala Salut, EAP Raval Sud, Barcelona, Spain, [Castell, Conxa] Autonomous Govt Catalonia, Publ Hlth Div, Barcelona, Spain, [Vendrell, Joan] Hosp Univ Joan XXIII, Dept Endocrinol & Nutr, Tarragona, Spain, [Carmena, Rafael] Hosp Clin Univ Valencia, Dept Med & Endocrinol, Valencia, Spain, [Catala, Miguel] Hosp Clin Univ Valencia, Dept Med & Endocrinol, Valencia, Spain, [Delgado, Elias] Univ Oviedo, Hosp Univ Cent Asturias, Fac Med & Ciencias Salud, Dept Endocrinol & Nutr, Oviedo, Spain, [Menendez, Edelmiro] Univ Oviedo, Hosp Univ Cent Asturias, Fac Med & Ciencias Salud, Dept Endocrinol & Nutr, Oviedo, Spain, [Girbes, Juan] Hosp Arnau Vilanova, Valencia, Spain, [Lopez-Alba, Alfonso] Fdn Hosp Jove, Gijon, Spain, [Serrano-Rios, Manuel] Hosp Clin San Carlos IdISSC, Inst Invest Sanitaria, Madrid, Spain, [Mora-Peces, Inmaculada] Canarian Hlth Serv, Tenerife, Spain, [Teresa Martinez-Larrad, Maria] CIBEROBN Spanish Biomed Res Ctr Physiopathol Obes, Pamplona, Spain, [Ortega, Emilio] CIBEROBN Spanish Biomed Res Ctr Physiopathol Obes, Pamplona, Spain, [Ortega, Emilio] Hosp Clin Barcelona, ICMDM, Dept Endocrinol & Nutr, Barcelona, Spain, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM, ISCIII Ministerio de Ciencia e Innovacion), Ministerio de Sanidad y Consumo, and Spanish Diabetes Society (SED)
Subjects: Questionnaires, Male, Dislipidemias, Cross-sectional study, Estudios transversales, España, Obesidad, Índice de masa corporal, Biochemistry, Body Mass Index, 0302 clinical medicine, Endocrinology, Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity [Medical Subject Headings], Public and Occupational Health, lcsh:Science, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, Mediterranean [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings], Chemicals and Drugs::Lipids::Glycerides::Triglycerides [Medical Subject Headings], Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], Aged, 80 and over, Diabetis, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias [Medical Subject Headings], Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity::Obesity, Abdominal [Medical Subject Headings], Cardiovascular Diseases, Obesitat, Enfermedades cardiovasculares, Factores de riesgo, medicine.medical_specialty, Endocrine Disorders, Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, HDL::Cholesterol, HDL [Medical Subject Headings], Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::Smoking [Medical Subject Headings], Qüestionaris, Triglicéridos, Exercici -- Aspectes sanitaris, 03 medical and health sciences, Diabetes Mellitus, Humans, Diseases::Cardiovascular Diseases [Medical Subject Headings], Exercise, Aged, Survey Research, Malalties cardiovasculars, Prevention, lcsh:R, Enfermedad crónica, Biology and Life Sciences, Physical Activity, Insulin-resistance, medicine.disease, Actividad motora, Obesity, Lipid metabolism, Cross-Sectional Studies, Dyslipidemia, Adherence, Glucosa, lcsh:Q, Body mass index, Demography, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology, Social::Life Style::Sedentary Lifestyle [Medical Subject Headings], Physiology, Physical fitness, Sistema cardiovascular -- Malalties, Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings], lcsh:Medicine, Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Obesidad abdominal, Geographical Locations, Glucose Metabolism, Risk Factors, Hábito de fumar, Medicine and Health Sciences, Prevalence, 030212 general & internal medicine, Prediabetes, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [Medical Subject Headings], Multidisciplinary, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings], Diabetes, Middle Aged, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Europe, Encuestas y cuestionarios, Physiological Parameters, Research Design, Carbohydrate Metabolism, Female, Research Article, Adult, Adolescent, 030209 endocrinology & metabolism, Vida sedentaria, Research and Analysis Methods, HDL-colesterol, Young Adult, Sex Factors, Diabetes mellitus, medicine, Adults, Espanya, Diseases::Endocrine System Diseases::Diabetes Mellitus::Prediabetic State [Medical Subject Headings], Sedentary lifestyle, business.industry, Estado prediabético, Body Weight, Dieta mediterránea, Metabolisme dels lípids, Diet, Metabolism, Spain, Metabolic Disorders, People and Places, Physical therapy, Sedentary Behavior, business, Prevalencia, Condició física
Abstract: Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM; ISCIII Ministerio de Ciencia e Innovacion); Ministerio de Sanidad y Consumo; Spanish Diabetes Society (SED), Brugnara, L., Murillo, S., Novials, A., Rojo-Martínez, G., Soriguer, F., Goday, A., Calle-Pascual, A., Castaño, L., Gaztambide, S., Valdés, S., Franch, J., Castell, C., Vendrell, J., Casamitjana, R., Bosch-Comas, A., Bordiú, E., Carmena, R., Catalá, M., Delgado, E., Girbés, J., López-Alba, A., Martínez-Larrad, M.T., Menéndez, E., Mora-Peces, I., Pascual-Manich, G., Serrano-Ríos, M., Gomis, R., Ortega, E.
Published: 2016

11. Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study

Author: Fernando Cardona, J M Gómez-Zumaquero, Isabel Leiva, Mora Murri, Francisco J. Tinahones, María Isabel Queipo-Ortuño, Federico Soriguer, [Murri,M, Cardona,F, Queipo-Ortuño,MI] Biomedical Research Laboratory, Hospital Universitario Virgen de la Victoria (FIMABIS), Málaga, Spain. [Leiva,I] Pediatric Endocrinology Service, Carlos Haya Materno Infantil Hospital, Málaga, Spain. [Gómez-Zumaquero,JM] Molecular Biology Laboratory, Civil Hospital (IMABIS foundation), Málaga, Spain. [Tinahones,FJ, Queipo-Ortuño,MI] CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. [Soriguer,F] Endocrinology and Nutrition Service, Carlos Haya Hospital, Málaga, Spain. [Soriguer,F] CIBER of Diabetes and Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain. [Tinahones,FJ] Endocrinology and Nutrition Service, Hospital Universitario Virgen de la Victoria, Málaga, Spain., This work was partially funded by a grant from CIBER, CB06/03/0018 of the Instituto de Salud Carlos III to MM, FC, FJT and MIQO, the Instituto de Salud Carlos III, Madrid, Spain (CP07/0095) to FJT, and and the Servicio Andaluz de Salud, Andalucía, Spain (PI0696/2010) to FJT.
Subjects: Male, Ácido Butírico, mode of delivery, type 1 diabetes, Physiology, Diabetes Mellitus Tipo 1, Gut flora, Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Acyclic::Butyric Acids [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Feces, HbA1c level, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Mucoproteins::Mucins [Medical Subject Headings], Lactobacillus, Prevotella, Child, Bifidobacterium, PCR-DGGE, Medicine(all), Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings], biology, Intestino, glycemic level, General Medicine, Biota, Niño, Hemoglobina A Glucosilada, Female, gut permeability, Anatomy::Digestive System::Gastrointestinal Tract::Intestines [Medical Subject Headings], Research Article, Firmicutes, Permeabilidad, Ácido Láctico, Real-Time Polymerase Chain Reaction, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus [Medical Subject Headings], Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 1 [Medical Subject Headings], mucin, Chemicals and Drugs::Carbohydrates::Glycosides::Hemoglobin A, Glycosylated [Medical Subject Headings], Diabetes mellitus, medicine, Humans, Organisms::Bacteria [Medical Subject Headings], Named Groups::Persons::Age Groups::Child [Medical Subject Headings], gut integrity, Type 1 diabetes, Bacteria, gut microbiota, Denaturing Gradient Gel Electrophoresis, Bacteroidetes, Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Hydroxy Acids::Lactates::Lactic Acid [Medical Subject Headings], Organisms::Bacteria::Gram-Positive Bacteria::Actinobacteria::Bifidobacterium [Medical Subject Headings], biology.organism_classification, medicine.disease, Phenomena and Processes::Chemical Phenomena::Permeability [Medical Subject Headings], Gastrointestinal Tract, lactic acid-producing bacteria, Diabetes Mellitus, Type 1, Phenomena and Processes::Biological Phenomena::Ecological and Environmental Phenomena::Environment::Ecosystem::Biodiversity::Biota [Medical Subject Headings], Case-Control Studies, Immunology, Metagenome, butyrate-producing bacteria
Abstract: Background A recent study using a rat model found significant differences at the time of diabetes onset in the bacterial communities responsible for type 1 diabetes modulation. We hypothesized that type 1 diabetes in humans could also be linked to a specific gut microbiota. Our aim was to quantify and evaluate the difference in the composition of gut microbiota between children with type 1 diabetes and healthy children and to determine the possible relationship of the gut microbiota of children with type 1 diabetes with the glycemic level. Methods A case-control study was carried out with 16 children with type 1 diabetes and 16 healthy children. The fecal bacteria composition was investigated by polymerase chain reaction-denaturing gradient gel electrophoresis and real-time quantitative polymerase chain reaction. Results The mean similarity index was 47.39% for the healthy children and 37.56% for the children with diabetes, whereas the intergroup similarity index was 26.69%. In the children with diabetes, the bacterial number of Actinobacteria and Firmicutes, and the Firmicutes to Bacteroidetes ratio were all significantly decreased, with the quantity of Bacteroidetes significantly increased with respect to healthy children. At the genus level, we found a significant increase in the number of Clostridium, Bacteroides and Veillonella and a significant decrease in the number of Lactobacillus, Bifidobacterium, Blautia coccoides/Eubacterium rectale group and Prevotella in the children with diabetes. We also found that the number of Bifidobacterium and Lactobacillus, and the Firmicutes to Bacteroidetes ratio correlated negatively and significantly with the plasma glucose level while the quantity of Clostridium correlated positively and significantly with the plasma glucose level in the diabetes group. Conclusions This is the first study showing that type 1 diabetes is associated with compositional changes in gut microbiota. The significant differences in the number of Bifidobacterium, Lactobacillus and Clostridium and in the Firmicutes to Bacteroidetes ratio observed between the two groups could be related to the glycemic level in the group with diabetes. Moreover, the quantity of bacteria essential to maintain gut integrity was significantly lower in the children with diabetes than the healthy children. These findings could be useful for developing strategies to control the development of type 1 diabetes by modifying the gut microbiota.
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12. Serum sCD163 levels are associated with type 2 diabetes mellitus and are influenced by coffee and wine consumption: Results of the di@bet.es study

Author: Joan Vendrell, Matilde R. Chacón, Sergio Valdés, Elías Delgado, Esther Solano, Gemma Rojo-Martínez, Felipe J. Chaves, Federico Soriguer, Elsa Maymó-Masip, Natalia Colomo, Pilar Hernández, M. Mar Rodríguez, Albert Goday, Química Física i Inorgànica, Universitat Rovira i Virgili., [Rojo-Martínez,G, Soriguer,F, Valdés,S, Colomo,N] UGCI de Endocrinología y Nutrición, Instituto de Biomedicina de Málaga (IBIMA), Hospital Regional Universitario, Málaga, Spain. [Rojo-Martínez,G, Maymó-Masip,E, Solano,E, Chaves,FJ, Colomo,N, Vendrell,J, Chacón,MR] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas CIBERDEM, Barcelona, Spain. Maymó-Masip,E, Hernández,P, Vendrel,J, Chacón,MR] Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain. [Rodríguez,MM] CIBERObn Fisiopatología, Obesidad y Nutrición, Institut D’investigacio Biomedica De Girona Dr Josep Trueta, Girona, Spain. [Goday,A] Department of Endocrinology and Nutrition Hospital del Mar, Parc de Salut Mar, Universitat Autónoma de Barcelona, Barcelona, Spain. [Chaves,FJ] Genotyping and Genetic Diagnosis Unit, Fundación de Investigación del Hospital Clínico de Valencia-INCLIVA, Valencia, Spain. [Delgado,E] Departamento de Medicina-Endocrinología y Nutrición, Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain., and This study was supported by projects from the Fondo de Investigación Sanitaria (FIS): PI 11/00049, PI 11/0085 and PI 11/02755 cofinanced by the European Regional Development Fund (ERDF). The Research Stabilization Programme of the Instituto de Salud Carlos III (ISCIII) co-financed by Institut Catala` de Salut (ICS) in Catalonia. Di@bet.es study was supported by CIBER in Diabetes and Associated Metabolic Disorders - CIBERDEM (ISCIII - Ministerio de Ciencia e Innovación), Ministerio de Sanidad and Spanish Society of Diabetes – SED.
Subjects: Male, Chemicals and Drugs::Complex Mixtures::Biological Agents::Plant Preparations::Coffee [Medical Subject Headings], Epidemiology, España, lcsh:Medicine, Wine, Type 2 diabetes, Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Logistic regression, Coffee, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Endocrinology, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior [Medical Subject Headings], Medicine and Health Sciences, Medicine, lcsh:Science, Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], Likelihood Functions, Multidisciplinary, Vino, Cytokine TWEAK, Chemicals and Drugs::Biological Factors::Biological Markers::Antigens, Differentiation::Antigens, CD [Medical Subject Headings], Middle Aged, 1932-6203, Funciones de verosimilitud, Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors [Medical Subject Headings], Hábitos alimenticios, Tumor Necrosis Factors, Cohort, Female, Café, Conducta bebedora, Research Article, medicine.medical_specialty, Phenomena and Processes::Chemical Phenomena::Physicochemical Phenomena::Solubility [Medical Subject Headings], Antigens, Differentiation, Myelomonocytic, Drinking Behavior, Check Tags::Male [Medical Subject Headings], Receptors, Cell Surface, Insulin resistance, Antigens, CD, Diabetes mellitus, Internal medicine, Humans, Solubilidad, Diabetic Endocrinology, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Likelihood Functions [Medical Subject Headings], business.industry, lcsh:R, Type 2 Diabetes Mellitus, Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 [Medical Subject Headings], Feeding Behavior, medicine.disease, Obesity, Chemicals and Drugs::Biological Factors::Biological Markers::Antigens, Differentiation::Antigens, Differentiation, Myelomonocytic [Medical Subject Headings], Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior::Food Habits [Medical Subject Headings], Technology, Industry, Agriculture::Food and Beverages::Beverages::Alcoholic Beverages::Wine [Medical Subject Headings], Biomarker Epidemiology, Diabetes Mellitus, Type 2, Solubility, Check Tags::Female [Medical Subject Headings], Spain, Diabetes mellitus tipo II, lcsh:Q, business
Abstract: Journal Article; Research Support, Non-U.S. Gov't; OBJECTIVE Serum levels of soluble TNF-like weak inducer of apoptosis (sTWEAK) and its scavenger receptor CD163 (sCD163) have been linked to insulin resistance. We analysed the usefulness of these cytokines as biomarkers of type 2 diabetes in a Spanish cohort, together with their relationship to food consumption in the setting of the Di@bet.es study. RESEARCH DESIGN AND METHODS This is a cross-sectional, matched case-control study of 514 type 2 diabetes subjects and 517 controls with a Normal Oral Glucose Tolerance Test (NOGTT), using data from the Di@bet.es study. Study variables included clinical and demographic structured survey, food frequency questionnaire and physical examination. Serum concentrations of sTWEAK and sCD163 were measured by ELISA. Linear regression analysis determined which variables were related to sTWEAK and sCD163 levels. Logistic regression analysis was used to estimate odd ratios of presenting type 2 diabetes. RESULTS sCD163 concentrations and sCD163/sTWEAK ratio were 11.0% and 15.0% higher, respectively, (P
Published: 2014
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13. Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro

Author: Carlos Dieguez, Federico Soriguer, Gemma Rojo-Martínez, Eva García-Escobar, Eduardo García-Fuentes, F. Rodriguez-Pacheco, María M. Malagón, Marta G. Novelle, María Jesús Vázquez, [Rodriguez-Pacheco,F, Novelle,MG, Vazquez,MJ, Dieguez,C] Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. [Rodriguez-Pacheco,F, Vazquez, MJ, Malagon,MM, Dieguez,C] CIBER FisiopatologÍa de la Obesidad y Nutrición (CIBERobn), Spain. [Rodriguez-Pacheco,F, Garcia-Escobar,E, Soriguer,F, Romo-Martinez,G, García-Fuentes,E] Endocrinology and Nutrition Service, Carlos Haya Hospital, Fundación IMABIS, MÁlaga, Spain. [Garcia-Escobar,E, Rojo-Martinez,G, García-Fuentes,E] CIBER Diabetes and Metabolic Illness (CIBER-DEM), Spain. [Malagon,MM] Department of Cellular Biology, Physiology and Inmunology, School of Siences, University of CÓrdoba, Córdoba, Spain., and Universidade de Santiago de Compostela. Departamento de Fisioloxía
Subjects: Male, Pituitary gland, Carboxy-Lyases, Adipose tissue, Antagonistas de la insulina, Hormona del crecimiento, Rats, Sprague-Dawley, Inmunidad, Resistin, Cells, Cultured, Fatty Acids, Ingestión de Alimentos, Hipófisis, medicine.anatomical_structure, Pituitary Gland, Lipogenesis, Anatomy::Endocrine System::Endocrine Glands::Gonads [Medical Subject Headings], hormones, hormone substitutes, and hormone antagonists, lcsh:RB1-214, Research Article, medicine.medical_specialty, Article Subject, Immunology, Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism::Lipogenesis [Medical Subject Headings], Radioimmunoassay, Adipokine, Biology, In Vitro Techniques, Real-Time Polymerase Chain Reaction, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines::Resistin [Medical Subject Headings], Ratas, In vivo, Internal medicine, lcsh:Pathology, medicine, Lipolysis, Animals, Lipogénesis, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutrition Processes::Eating [Medical Subject Headings], Gónadas, Inflammation, Inflamación, Carnitine O-Palmitoyltransferase, Interleukin-6, Tumor Necrosis Factor-alpha, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormone Antagonists::Insulin Antagonists [Medical Subject Headings], nutritional and metabolic diseases, Lipid metabolism, Cell Biology, Phenomena and Processes::Immune System Phenomena::Immunity [Medical Subject Headings], Lipid Metabolism, Anatomy::Endocrine System::Endocrine Glands::Pituitary Gland [Medical Subject Headings], Rats, Lipoprotein Lipase, Endocrinology, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats [Medical Subject Headings], Resistina, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::Growth Hormone [Medical Subject Headings], Fatty Acid Synthases, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings]
Abstract: The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary cells cultures with the adipokine. Although adipose tissue is the primary source of resistin, it is also expressed in other tissues, including the pituitary. The aim of this study is to investigate the possible action of resistin on the lipid metabolism in the pituitary gland in vivo (rats in two different nutritional status, fed and fast, treated with resistin on acute and a chronic way) and in vitro (adenopituitary cell cultures treated with the adipokine). Here, by a combination of in vivo and in vitro experimental models, we demonstrated that central acute and chronic administration of resistin enhance mRNA levels of the lipid metabolic enzymes which participated on lipolysis and moreover inhibiting mRNA levels of the lipid metabolic enzymes involved in lipogenesis. Taken together, our results demonstrate for the first time that resistin has a regulatory role on lipid metabolism in the pituitary gland providing a novel insight in relation to the mechanism by which this adipokine can participate in the integrated control of lipid metabolism. Sara Borrell Postdoctoral program; BFU 2011 and CIBER Obesidad y Nutricion (Instituto de Salud Carlos Tercero (ISCIII), Ministerio de Ciencia e Innovacion). Juan de la Cierva Program (Ministerio de Educacion y Ciencia) SI
Published: 2012

14. Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaen and Cordoba (Spain) 2008

Author: Emilio Ros, Francesco Visioli, Francisco José Muriana, Francisco Pérez-Jiménez, Javier A. Menendez, R. De Caterina, Pablo Perez-Martinez, C. La Vecchia, José Manuel Fernández-Real, Marino Uceda, Juan Ruano, Rocio Abia, Eduard Escrich, Federico Soriguer, Maurizio Battino, J.A. Paniagua, M. Pineda-Priego, Antonia Trichopoulou, D. Lairon, J. R. Villar-Ortiz, Nikos Yiannakouris, Javier Delgado-Lista, MCarmen Ramirez-Tortosa, Henrik E. Poulsen, Rosa Solà, José J. Gaforio, Demosthenes B. Panagiotakos, C. Alarcón de la Lastra, Lluis Serra-Majem, Dolores Corella, Fernando López-Segura, Javier S. Perona, Ramon Estruch, Jose Lopez-Miranda, José L. Quiles, Jose M. Ordovas, María Isabel Covas, R. De La Torre-Fornell, Maria Angeles Peinado, Katherine Esposito, Lina Badimon, Dario Giugliano, Pedro Mata, J. Chamorro-Quirós, Vincenzo Solfrizzi, Montserrat Solanas, Jesús Osada, J. M. Villalba-Montoro, LÓPEZ MIRANDA, J, PÉREZ JIMÉNEZ, F, Ros, E, DE CATERINA, R, Badimón, L, Covas, Mi, Escrich, E, Ordovás, Jm, Soriguer, F, Abiá, R, DE LA LASTRA, Ca, Battino, M, Corella, D, CHAMORRO QUIRÓS, J, DELGADO LISTA, J, Giugliano, Dario, Esposito, Katherine, Estruch, R, FERNANDEZ REAL, Jm, Gaforio, Jj, LA VECCHIA, C, Lairon, D, LÓPEZ SEGURA, F, Mata, P, Menéndez, Ja, Muriana, Fj, Osada, J, Panagiotakos, Db, Paniagua, Ja, PÉREZ MARTINEZ, P, Perona, J, Peinado, Ma, PINEDA PRIEGO, M, Poulsen, He, Quiles, Jl, RAMÍREZ TORTOSA, Mc, Ruano, J, SERRA MAJEM, L, Solá, R, Solanas, M, Solfrizzi, V, DE LA TORRE FORNELL, R, Trichopoulou, A, Uceda, M, VILLALBA MONTORO, Jm, VILLAR ORTIZ, Jr, Visioli, F, and Yiannakouris, N.
Subjects: Aging, medicine.medical_specialty, Consensus, Mediterranean diet, Endocrinology, Diabetes and Metabolism, Population, Medicine (miscellaneous), Blood lipids, Type 2 diabetes, Diet, Mediterranean, Risk Assessment, Cognition, Life Expectancy, Risk Factors, Neoplasms, Internal medicine, Environmental health, Diabetes Mellitus, medicine, Mediterranean diet Phenolic compounds, Plant Oils, Obesity, Cognitive decline, education, Olive Oil, Cancer, Metabolic Syndrome, education.field_of_study, Nutrition and Dietetics, medicine.diagnostic_test, business.industry, Diabetes, medicine.disease, Cardiovascular disease, Metabolic syndrome, Endocrinology, Cardiovascular Diseases, Health, Chronic Disease, Cardiology and Cardiovascular Medicine, Lipid profile, business, Olive oil
Abstract: Olive oil (OO) is the most representative food of the traditional Mediterranean Diet (MedDiet). Increasing evidence suggests that monounsaturated fatty acids (MUFA) as a nutrient, OO as a food, and the MedDiet as a food pattern are associated with a decreased risk of cardiovascular disease, obesity, metabolic syndrome, type 2 diabetes and hypertension. A MedDiet rich in OO and OO per se has been shown to improve cardiovascular risk factors, such as lipid profiles, blood pressure, postprandial hyperlipidemia, endothelial dysfunction, oxidative stress, and antithrombotic profiles. Some of these beneficial effects can be attributed to the OO minor components. Therefore, the definition of the MedDiet should include OO. Phenolic compounds in OO have shown antioxidant and anti-inflammatory properties, prevent lipoperoxidation, induce favorable changes of lipid profile, improve endothelial function, and disclose antithrombotic properties. Observational studies from Mediterranean cohorts have suggested that dietary MUFA may be protective against age-related cognitive decline and Alzheimer's disease. Recent studies consistently support the concept that the OO-rich MedDiet is compatible with healthier aging and increased longevity. In countries where the population adheres to the MedDiet, such as Spain, Greece and Italy, and OO is the principal source of fat, rates of cancer incidence are lower than in northern European countries. Experimental and human cellular studies have provided new evidence on the potential protective effect of OO on cancer. Furthermore, results of case-control and cohort studies suggest that MUFA intake including OO is associated with a reduction in cancer risk (mainly breast, colorectal and prostate cancers)., CIBEROBN is an initiative of ISCIII and CEAS Foundation, Spain.
Published: 2010

15. Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life

Author: María Teresa Anarte, Inés Velasco, Alberto Machado, Alvaro Rodriguez, Federico Soriguer, Baltasar Sánchez-Muñoz, Jose Antonio Muela, Eduardo García-Fuentes, Francisco Félix Caballero, Stella González-Romero, Piedad Santiago, M. J. Garriga, Maria C González-Fernández, Mónica Carreira, [Velasco,I] Hospital La Merced, Osuna, Spain. [Carreira,M, Caballero,FF, Anarte,MT] Facultad de Psicología, Universidadde Málaga, Málaga, Spain. [Santiago,P] Servicio de Endocrinología y Nutrición, Hospital General, Jaén, Spain. [Muela,JA, Rodríguez,A] Facultad de Humanidades y Ciencias de la Educación, Departamento de Psicología, Universidad de Jaén, Jaén, Spain. [García-Fuentes,E] Fundación Imabis, Málaga, Spain. Centro de Investigación Biomédica en Red de Fisiopatología Obesidad y Nutrición, ISCIII, Málaga, Spain. [Sánchez-Muñoz,B] Laboratorio de Análisis Clínicos, Hospital General, Jaén, Spain. [Garriga,MJ] Laboratorio de Hormonas, Hospital Universitario Carlos Haya, Málaga, Spain. [González-Fernandez,MC] Unidad de Investigación, Hospital la Merced, Osuna, Spain. [Machado,A] Hospital Punta de Europa de Algeciras, Cádiz, Spain. [González-Romero,S, Soriguer,F] Servicio de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Málaga, Spain. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Málaga, Spain., and This work was supported by Fundación Progreso y Salud (PI URM 82044).
Subjects: Male, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Hormonas tiroideas, Thyroid Gland, Glándula Tiroides, Biochemistry, Bayley Scales of Infant Development, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Child Development, Cognition, Endocrinology, Technology, Industry, Agriculture::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings], Pregnancy, Medicine, Anatomy::Endocrine System::Endocrine Glands::Thyroid Gland [Medical Subject Headings], Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings], Psychomotor learning, Yodo, Gestation, Female, Thyroid function, Named Groups::Persons::Age Groups::Infant [Medical Subject Headings], Iodine, Adult, Chemicals and Drugs::Inorganic Chemicals::Elements::Halogens::Iodine [Medical Subject Headings], Thyroid Hormones, medicine.medical_specialty, Embarazo, Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Human Development::Child Development [Medical Subject Headings], Suplementos Dietéticos, chemistry.chemical_element, Check Tags::Male [Medical Subject Headings], Context (language use), Internal medicine, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Humans, Cognición, Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition [Medical Subject Headings], business.industry, Biochemistry (medical), Infant, medicine.disease, El Niño, chemistry, Check Tags::Female [Medical Subject Headings], Dietary Supplements, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Thyroid Hormones [Medical Subject Headings], business
Abstract: Journal Article; Research Support, Non-U.S. Gov't; "Comment in: What do we know about iodine supplementation in pregnancy? [J Clin Endocrinol Metab. 2009]" (Nota tomada de PubMed). CONTEXT The association between thyroid function during pregnancy and the later mental and psychomotor development of the child is supported by numerous experimental, clinical, and epidemiological studies. OBJECTIVE The aim of the study was to evaluate the psychological development of infants aged 3 to 18 months whose mothers had received 300 microg of potassium iodide during the first trimester of their pregnancy and compare with infants whose mothers had received no iodine supplements. DESIGN AND STUDY SUBJECTS: The study included 133 women who had received 300 microg of potassium iodine and 61 women who had received no iodine supplements. MAIN OUTCOME MEASURES The neuropsychological status of the children was evaluated with the Bayley Scales of Infant Development, and measurements were made of TSH, free T(3), free T(4), and urinary iodine. RESULTS Those children whose mothers had received an iodine supplement of 300 microg had a more favorable psychometric assessment than those of the other group of mothers. They had higher scores on the Psychomotor Development Index (P = 0.02) and the Behavior Rating Scale. CONCLUSIONS Dietary iodine supplements not only have no harmful effect on the neurodevelopment of the children, they may even be beneficial. Given the possible presence of confounding variables not controlled for in this study, these findings should be considered as preliminary. Yes 2010-09
Published: 2009

16. Effect of long-term administration of cross-sex hormone therapy on serum and urinary uric acid in transsexual persons

Author: Raquel Yahyaoui, Gemma Rojo-Martínez, Juan J. Haro-Mora, J Martínez, María Cruz Almaraz, I González, J M Gómez-Zumaquero, Isabel Esteva, Virginia Hernando, Federico Soriguer, Sonsoles Morcillo, Andalusian Gender Team, [Yahyaoui, R] Clinical Laboratory. [Esteva,I, Almaraz,MC, Gonzalez,I, Soriguer,F] Department of Endocrinology. [Martinez,J] Department of Psychiatry. [Haro-Mora,JJ, Morcillo,S, Rojo-Martinez,G, Gomez-Zumaquero,JM] Endocrinological Research Laboratory. [Hernando,V] Family Physician, Andalusian Gender Team, Carlos Haya University Hospital, Málaga, Spain., and This work was partly supported by a grant from theAndalusian Health Service (SAS 0060/2006). This team belongs to the CIBER of Physiopathology of Obesity and Nutrition (CB06/03/0018),RETICS of Diabetes and Metabolism (RD06/0015/0008), and CIBERDEM CB07/08/0019 of the Instituto de Salud Carlos III, Spain.
Subjects: Blood Glucose, Male, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Phenomena and Processes::Physical Phenomena::Time::Time Factors [Medical Subject Headings], Clinical Biochemistry, Urine, Resistencia a la Insulina, Biochemistry, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], chemistry.chemical_compound, Endocrinology, Sex hormone-binding globulin, Hormone replacement therapy (female-to-male), Insulina, Ácido Úrico, Insulin, Medicine, Hyperuricemia, Gonadal Steroid Hormones, Prospective cohort study, Masculino, biology, Estradiol, Adulto, Femenino, Transexualismo, Hormonas Esteroides Gonadales, Humanos, Female, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pancreatic Hormones::Insulins::Proinsulin::Insulin [Medical Subject Headings], Adult, medicine.medical_specialty, Psychiatry and Psychology::Mental Disorders::Sexual and Gender Disorders::Sexual Dysfunctions, Psychological::Transsexualism [Medical Subject Headings], Check Tags::Male [Medical Subject Headings], Excretion, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance [Medical Subject Headings], Glucemia, Internal medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings], Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Humans, Relación Dosis-Respuesta a Droga, Dose-Response Relationship, Drug, business.industry, Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Dose-Response Relationship, Drug [Medical Subject Headings], Biochemistry (medical), Chemicals and Drugs::Heterocyclic Compounds::Alkaloids::Xanthines::Uric Acid [Medical Subject Headings], medicine.disease, Uric Acid, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gonadal Hormones::Gonadal Steroid Hormones [Medical Subject Headings], chemistry, Check Tags::Female [Medical Subject Headings], Estudios de Seguimiento, biology.protein, Uric acid, Hormone therapy, Insulin Resistance, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gonadal Hormones::Gonadal Steroid Hormones::Estradiol Congeners::Estradiol [Medical Subject Headings], business, Factores de Tiempo, Transsexualism, Follow-Up Studies, Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose::Blood Glucose [Medical Subject Headings]
Abstract: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; BACKGROUND. Transsexual persons afford a very suitable model to study the effect of sex steroids on uric acid metabolism. DESIGN. This was a prospective study to evaluate the uric acid levels and fractional excretion of uric acid (FEUA) in a cohort of 69 healthy transsexual persons, 22 male-to-female transsexuals (MFTs) and 47 female-to-male transsexuals (FMTs).The subjects were studied at baseline and 1 and 2 yr after starting cross-sex hormone treatment. RESULTS. The baseline levels of uric acid were higher in the MFT group.Compared with baseline, uric acid levels had fallen significantly after 1 yr of hormone therapy in the MFT group and had risen significantly in the FMT group. The baseline FEUA was greater in the FMT group. After 2 yr of cross-sex hormone therapy, the FEUA had increased in MFTs (P = 0.001) and fallen in FMTs (P = 0.004).In MFTs, the levels of uric acid at 2 yr were lower in those who had received higher doses of estrogens (P = 0.03),and the FEUA was higher (P = 0.04).The FEUA at 2 yr was associated with both the estrogen dose (P = 0.02) and the serum levels of estradiol-17beta (P =0.03).In MFTs, a correlation was found after 2 yr of therapy between the homeostasis model assessment of insulin resistance and the serum uric acid (r = 0.59; P = 0.01). CONCLUSIONS. Serum levels of uric acid and the FEUA are altered in transsexuals as a result of cross-sex hormone therapy.The results concerning the MFT group support the hypothesis that the lower levels of uric acid in women are due to estrogen-induced increases in FEUA. Yes
Published: 2008

17. Impact of obesity-related genes in Spanish population

Author: Richard S. Cooper, Fernando Martínez-García, Maria L. Mansego, Juan Carlos Martín-Escudero, Gemma Rojo-Martínez, Sonsoles Morcillo, Josep Redon, Monica Pineda Alonso, Griselda De Marco-Solar, Federico Soriguer, Felipe J. Chaves, [Martínez-García,F, Redón,J] Hypertension Clinic, Hospital Clínico Universitario and INCLIVA, University of Valencia, Valencia, Spain. [Martínez-García,F, Redón,J] CIBER 03/06 Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Minister of Health, Santiago de Compostela, Spain. [Mansego,ML, Marco-Solar,GD, Chaves,FJ] Genotyping and Genetic Diagnosis Unit, Hospital Clínico Research Foundation and INCLIVA, Valencia, Spain. [Mansego,ML, Rojo-Martínez,G, Morcillo,S, Soriguer,F, Chaves,FJ] CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona,Spain. [Rojo-Martínez,G, Soriguer,F] Endocrinology and nutrition service, Carlos Haya Universitary Hospital, Málaga, Spain. [Pineda Alonso,M, Martín-Escudero,JC] Internal Medicine, Rio Hortega Hospital, University of Valladolid, Valladolid, Spain. [Cooper,RS] Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, IL, USA. [Redón,J] Internal Medicine, Hospital Clínico, Valencia, Spain., This work was supported by CIBER of Diabetes and metabolic diseases (CIBERDEM) and CIBER obesity and nutrition (CIBEROB). CIBERDEM and CIBEROBN are initiatives of the 'Fondo de Investigaciones Sanitarias', INGENFRED (Ref. CIBER-02-08-2009) grant from CIBERDEM, PI070497 from the 'Fondo de Investigaciones Sanitarias', ACOMP/2009/201 and PROMETEO/2009/029 from the Valencian Government, SAF2005-02883 from Ministerio de Educacion y Ciencia, P06-CTS-01684 from Andalusian Governement, and Gema Rojo-Martinez [CP06/00133], and F. Javier Chaves [FIS01/3047] are contracted by the Health Institute Carlos III.
Subjects: Male, Linkage disequilibrium, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Genome-Wide Association Study [Medical Subject Headings], Polimorfismo de nucleótido simple, España, Estudio de asociación del genoma completo, Obesidad, Índice de masa corporal, FTO gene, Linkage Disequilibrium, Body Mass Index, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Genetics(clinical), Genetics (clinical), Genetics, Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], education.field_of_study, Middle Aged, Genetic score, Ataxins, Female, Research Article, Adult, Adolescent, Genotype, Cell Adhesion Molecules, Neuronal, Population, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Check Tags::Male [Medical Subject Headings], Nerve Tissue Proteins, Single-nucleotide polymorphism, Biology, GPI-Linked Proteins, Polymorphism, Single Nucleotide, White People, Young Adult, medicine, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Humans, Obesity, education, Genotyping, Alleles, Adaptor Proteins, Signal Transducing, Aged, Genetic association, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide [Medical Subject Headings], Proteins, Andalucía, medicine.disease, Genética, Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Biometry::Anthropometry::Body Mass Index [Medical Subject Headings], Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [Medical Subject Headings], Diabetes Mellitus, Type 2, Check Tags::Female [Medical Subject Headings], Spain, Body mass index
Abstract: Background The objective was to investigate the association between BMI and single nucleotide polymorphisms previously identified of obesity-related genes in two Spanish populations. Forty SNPs in 23 obesity-related genes were evaluated in a rural population characterized by a high prevalence of obesity (869 subjects, mean age 46 yr, 62% women, 36% obese) and in an urban population (1425 subjects, mean age 54 yr, 50% women, 19% obese). Genotyping was assessed by using SNPlex and PLINK for the association analysis. Results Polymorphisms of the FTO were significantly associated with BMI, in the rural population (beta 0.87, p-value 2 in Hortega and 2.0 kg/m2 in Pizarra. Overall, the obesity predictive value was low (less than 1%). Conclusion The risk associated with polymorphisms is low and the overall effect on BMI or obesity prediction is minimal. A weighted genetic risk score based on genes mainly acting through central nervous system mechanisms was associated with BMI but it yields minimal clinical prediction for the obesity risk in the general population.
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18. Serum phospholipid fatty acid profile and dietary intake in an adult Mediterranean population with cystic fibrosis

Author: Inmaculada Gaspar, Antonio Dorado, Montserrat Gonzalo, Eva García-Escobar, Gemma Rojo-Martínez, Gabriel Olveira, Alicia Padilla, Federico Soriguer, Casilda Olveira, [Olveira,G, Rojo-Martínez,G, García-Escobar,E, Gonzalo,M, Soriguer,F] Servicio de Endocrinología y Nutrición,Hospital Universitario Carlos Haya, Málaga, España. [Dorado,A, Olveira,C, Padilla,A, Gaspar,I] Servicio de Neumología, Hospital Universitario Carlos Haya, Málaga, España., and The present study was partly financed by a grant from the Consejería de Salud de la Junta de Andalucía (02/150) and by a grant from the Instituto de Salud Carlos III, Metabolism and Nutrition Network RCMYN (C03/08), Spain.
Subjects: Male, Cystic Fibrosis, Medicine (miscellaneous), Diet, Mediterranean, Fibrosis Quística, Cystic fibrosis, Pulmonary function testing, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], chemistry.chemical_compound, Serum phospholipid fatty acids, Fosfolípidos, Medicine, Prospective Studies, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, Mediterranean [Medical Subject Headings], Lung, Phospholipids, chemistry.chemical_classification, education.field_of_study, Nutrition and Dietetics, Fatty Acids, Chemicals and Drugs::Lipids::Fatty Acids [Medical Subject Headings], Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Energy Intake [Medical Subject Headings], Biochemistry, Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings], Dieta, Female, Polyunsaturated fatty acid, Adult, medicine.medical_specialty, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], Normal diet, Adolescent, Linoleic acid, Population, Check Tags::Male [Medical Subject Headings], Chemicals and Drugs::Lipids::Fats::Dietary Fats [Medical Subject Headings], Diseases::Respiratory Tract Diseases::Lung Diseases::Cystic Fibrosis [Medical Subject Headings], Internal medicine, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Humans, Ácidos Grasos, Chemicals and Drugs::Lipids::Phospholipids [Medical Subject Headings], education, Fatty acid metabolism, business.industry, Fatty acid, Anatomy::Respiratory System::Lung [Medical Subject Headings], medicine.disease, Dietary Fats, Diet, Endocrinology, Check Tags::Female [Medical Subject Headings], chemistry, business, Energy Intake
Abstract: The relative importance of the usual diet in serum phospholipids in subjects with cystic fibrosis (CF) has been poorly studied. To compare the fatty acid profile in serum phospholipids from adult CF subjects with that of healthy subjects, and determine the role of the normal diet in this profile, we studied thirty-seven adult CF subjects with stable pulmonary disease and thirty-seven healthy controls matched for age, sex and nutritional status. A dietary questionnaire was obtained, anthropometric data were recorded, and the fatty acid profile measured by GLC. Compared with the controls, the percentages of myristic, palmitoleic and stearic acids and total MUFA were significantly higher in the CF group, and DHA, linoleic acid, total PUFA and n−6 fatty acids were significantly lower in the CF group. The CF subjects with worse pulmonary function and with pancreatic insufficiency had significantly lower levels of linoleic and n−6 fatty acids. The total energy intake was significantly higher in the CF subjects, although the energy distribution in the CF subjects and the controls was not different for the carbohydrates, lipids and proteins. No differences were detected in fat intake for MUFA (51 (sd 4) v. 52 (sd 4) %) or saturated fatty acids (33·5 (sd 5) v. 31·2 (sd 3·8) %), but the PUFA were slightly lower in the CF subjects (15·4 (sd 4·5) v. 17·4 (sd 4·2) %; P=0·02). The usual dietary intake of fatty acids by adult CF subjects does not appear to explain the difference in the fatty acid profile compared with controls. This suggests an abnormal fatty acid metabolism in CF subjects.
Published: 2006

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18 results on '"Soriguer F"'

1. The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study

2. Evaluation of Health-Related Quality of Life according to Carbohydrate Metabolism Status: A Spanish Population-Based Study (Di@bet.es Study)

3. Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population

4. Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects

5. ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism

6. Intake and home use of olive oil or mixed oils in relation to healthy lifestyles in a Mediterranean population. Findings from the prospective Pizarra study

7. Amniotic fluid iodine concentrations do not vary in pregnant women with varying iodine intake

8. Inverse relation between levels of anti-oxidized-LDL antibodies and eicosapentanoic acid (EPA)

9. Epigenetic Biomarkers of Transition from Metabolically Healthy Obesity to Metabolically Unhealthy Obesity Phenotype: A Prospective Study

10. Low physical activity and its association with diabetes and other cardiovascular risk factors: a nationwide, population-based study

11. Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study

12. Serum sCD163 levels are associated with type 2 diabetes mellitus and are influenced by coffee and wine consumption: Results of the di@bet.es study

13. Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro

14. Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaen and Cordoba (Spain) 2008

15. Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life

16. Effect of long-term administration of cross-sex hormone therapy on serum and urinary uric acid in transsexual persons

17. Impact of obesity-related genes in Spanish population

18. Serum phospholipid fatty acid profile and dietary intake in an adult Mediterranean population with cystic fibrosis

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18 results on '"Soriguer F"'

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