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Dysmennorrhoea is a common problem in women of reproductive age, is a very serious problem that canoften directly effect the quality of life and cause periodic college absenteeism. Primary dysmennorrhoea orpainful menstruation without pelvic pathology is one of the most common complaints in women’s medicineand Secondary dysmennorrhoea is pain that is caused by a disorder or any infection in the woman’sreproductive organs. Aerobic exercise is commonly cited as a probable remedy for menstrual symptomswith limited research available. The purpose of the study was to observe the effect of aerobic exercise onprimary dysmennorrhoea.Material and Methodology:- A quantitative research approach with Pre-Experimental design with onegroup pre-test and post-test was used. The study was conducted in Haldwani, Uttarakhand. The convenientsampling techniques were used to select the study subjects. Date was collected from 40 adolescent girls byusing structured knowledge questionnaire.Result:- The pre-test was taken by using structured knowledge questionnaire designed by researcher andadministered structured teaching programme on same day. After 7 days post test was taken. The data wasanalyzed by using frequency, percentage, mean, standard deviation was used to describe the result. Inferentialstatistics like paired t test, Chi square test. The overall mean pre-test knowledge score of adolescent girlswas 0.322± 24.27 and mean post-test knowledge score of adolescent girls was 0.634± 46.902 and the meandifference was 0.312. The ‘t’ value was 12.177.Hence the scores predicted that the significant differencebetween the mean pre-test and post-test at p

Background Osteoporosis is an asymptomatic bone disorder leading to altered bone microarchitecture, mineralization and strength. Musa paradisiaca has been reported to have antioxidant and anti-inflammatory effects in various diseases. Its impact on postmenopausal osteoporosis has not been investigated yet. Purpose The intention of the current study was to evaluate the bone regeneration and osteoprotective potential of extract and fraction of M. paradisiaca flower in ovariectomized (Ovx) Sprague Dawley (SD) rats, a model of post-menopausal bone loss. The study also aims to identify osteogenic compounds from active fraction. Methods Ethanolic extract (MFE) and butanolic fraction (MFE-Bu) from flower of M. paradisiaca were prepared and their efficacy was tested in rat femur osteotomy model at different doses. Effective dose from both extract (250 mg/kg) and fraction (50 mg/kg) were taken for study in osteopenic bone loss model. PTH was taken as reference standard (20 µg/kg/twice a week). Bones were harvested at autopsy for dynamic and static histomorphometry. Serum was collected for ELISA. Pure compounds were isolated from butanolic fraction (MFE-Bu), and were assessed for their osteogenic effect. Results MFE and MFE-Bu were observed for their potential in bone healing and prevention of bone loss. Both MFE and MFE-Bu promoted new bone regeneration at injury site as assessed by microCT and calcein dye labeling studies. These also led to restoration of bone microarchitecture deteriorated as a result of osteopenia and improved bone biomechanical properties. Extract as well as the fraction exhibited dual bone anabolic and anti-resorptive properties where they elevated serum procollagen type I N-terminal propeptide (P1NP), a bone formation marker and suppressed serum C-telopeptide of type I collagen (CTX-1), a bone resorption marker. As many as four osteogenic compounds were isolated from MFE-Bu. Oleracein-E was found to be the most potent osteogenic agent based on osteoblast differentiation, mineralization assays, qPCR and protein expression studies. Conclusion Our studies demonstrates that ethanolic extract from the flower of M. paradisiaca and its butanolic fraction exhibit dual osteogenic and anti-resorptive potential, and have an advantage over PTH which though promotes bone formation but is also bone catabolic in nature.