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Your search keyword '"Song-Zi Wang"' showing total 3 results
Start Over Author "Song-Zi Wang" Topic medicine
3 results on '"Song-Zi Wang"'

1. Role of a novel functional variant in the PPP2R1A promoter on the regulation of PP2A-Aalpha and the risk of hepatocellular carcinoma.

Author

Hui-Feng Chen, Jian-Rong Mai, Jian-Xin Wan, Yan-fang Gao, Li-Na Lin, Song-Zi Wang, Yu-Xi Chen, Chen-Zi Zhang, Yu-Jing Zhang, Bin Xia, Kun Liao, Yu-Chun Lin, and Zhong-Ning Lin

Subjects
Medicine, Science
Abstract

Previously, we identified the genetic variant -241 (-/G) (rs11453459) in the PP2A-Aα gene (PPP2R1A) promoter and demonstrated that this variant influences the DNA-binding affinity of nuclear factor-kappa B (NF-κB). In this study, we further confirmed that the transcriptional activity of PPP2R1A may be regulated by NF-κB through the functional genetic variant -241 (-/G). Moreover, we also demonstrated that the methylation status of CpG islands in the promoter of PPP2R1A influences the activity of this gene promoter. Few studies have examined the role of this -241 (-/G) variant in genetic or epigenetic regulation in hepatocellular carcinoma (HCC). To investigate whether this functional variant in the PPP2R1A promoter is associated with the risk of HCC and confirm the function of the -241 (-/G) variant in the HCC population, we conducted a case-control study involving 251 HCC cases and 252 cancer-free controls from a Han population in southern China. Compared with the -241 (--) homozygote, the heterozygous -241 (-G) genotype (adjusted OR = 0.32, 95% confidence interval (CI) = 0.17-0.58, P

Published
2013
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2. Effects of acupuncture on the tissue distribution of Paclitaxel in lung carcinoma mice

Author

Ze-Dong Cheng, Kim Andre, Chun-Ri Li, Song-zi Wang, Jong-Myung Ha, Yi-Guo Chen, and Zhi-Xing Zhang

Subjects
Oncology, medicine.medical_specialty, Lung, genetic structures, business.industry, General Medicine, respiratory system, medicine.disease, respiratory tract diseases, chemistry.chemical_compound, Text mining, medicine.anatomical_structure, Complementary and alternative medicine, Paclitaxel, chemistry, Medicine public health, Internal medicine, medicine, Carcinoma, Acupuncture, Pharmacology (medical), Tissue distribution, Mouse Lung, business
Abstract

To study whether acupuncture affects the tissue distribution of Paclitaxel in mouse lung carcinoma.Totally 90 mice were divided into Paclitaxel group, Paclitaxel + Feishu (BL13) group, and Paclitaxel + Lingtai (DU10) group. Each group was consisted of 30 mice. After Paclitaxel injection, the mice received electro-acupuncture at Feishu or Lingtai acupoints once a day for 8 days. The effect of acupuncture on the tissue distribution of Paclitaxel was evaluated using high-performance liquid chromatography at 1, 2, and 3 h, respectively. The lung, liver, spleen, and kidney were examined for the concentration of Paclitaxel seperately.Paclitaxel was widely distributed in various organs, particularly in the lung, liver, and kidney. Acupuncture at Lingtai or Feishu acupoints resulted in an obvious decrease of Paclitaxel distribution in kidney and delayed Paclitaxel distribution in liver. Meanwhile, it increased the time of metabolism. Acupuncture at Feishu acupoint facilitated the delivery of Paclitaxel to lung more effectively than did acupuncture at Lingtai acupoint.Applying acupuncture at particular acupoints can influence tissue distribution of Paclitaxel. Tissue distribution change might be one of the mechanisms of acupuncture treatment during chemotherapy.

Published
2014
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3. Role of a novel functional variant in the PPP2R1A promoter on the regulation of PP2A-Aalpha and the risk of hepatocellular carcinoma

Author

Yujing Zhang, Jian-Xin Wan, Li-Na Lin, Jian-Rong Mai, Zhong-Ning Lin, Yan-fang Gao, H. Chen, Chen-Zi Zhang, Bin Xia, Song-Zi Wang, Yuxi Chen, Kun Liao, and Yu-Chun Lin

Subjects
Adult, Male, Carcinoma, Hepatocellular, Transcription, Genetic, Epidemiology, lcsh:Medicine, Biology, Polymorphism, Single Nucleotide, medicine, Biomarkers, Tumor, Genetics, Humans, Genetic Predisposition to Disease, Protein Phosphatase 2, lcsh:Science, Promoter Regions, Genetic, Multidisciplinary, Population Biology, lcsh:R, Liver Neoplasms, NF-kappa B, DNA Methylation, medicine.disease, Gene Expression Regulation, Neoplastic, Haplotypes, Hepatocellular carcinoma, Genetic Polymorphism, Medicine, lcsh:Q, Female, Epigenetics, DNA modification, Population Genetics, Cancer Epidemiology, Research Article
Abstract

Previously, we identified the genetic variant -241 (-/G) (rs11453459) in the PP2A-Aα gene (PPP2R1A) promoter and demonstrated that this variant influences the DNA-binding affinity of nuclear factor-kappa B (NF-κB). In this study, we further confirmed that the transcriptional activity of PPP2R1A may be regulated by NF-κB through the functional genetic variant -241 (-/G). Moreover, we also demonstrated that the methylation status of CpG islands in the promoter of PPP2R1A influences the activity of this gene promoter. Few studies have examined the role of this -241 (-/G) variant in genetic or epigenetic regulation in hepatocellular carcinoma (HCC). To investigate whether this functional variant in the PPP2R1A promoter is associated with the risk of HCC and confirm the function of the -241 (-/G) variant in the HCC population, we conducted a case-control study involving 251 HCC cases and 252 cancer-free controls from a Han population in southern China. Compared with the -241 (--) homozygote, the heterozygous -241 (-G) genotype (adjusted OR = 0.32, 95% confidence interval (CI) = 0.17-0.58, P

Published
2012

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