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2 results on '"Soha Salman"'

1. Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia.

Author

Filippo Romanelli, AnthonyMarco Corbo, Maryam Salehi, Manisha C Yadav, Soha Salman, David Petrosian, Omid J Rashidbaigi, Jesse Chait, Jes Kuruvilla, Maria Plummer, Ilian Radichev, Kenneth B Margulies, A Martin Gerdes, Anthony B Pinkerton, José Luis Millán, Alexei Y Savinov, and Olga V Savinova

Subjects
Medicine, Science
Abstract

Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelium leads to arterial calcification in mice. The purpose of this study was to examine the effect of elevated endothelial TNAP on coronary atherosclerosis. In addition, we aimed to examine endogenous TNAP activity in human myocardium.A vascular pattern of TNAP activity was observed in human non-failing, ischemic, and idiopathic dilated hearts (5 per group); no differences were noted between groups in this study. Endothelial overexpression of TNAP was achieved in mice harboring a homozygous recessive mutation in the low density lipoprotein receptor (whc allele) utilizing a Tie2-cre recombinase (WHC-eTNAP mice). WHC-eTNAP developed significant coronary artery calcification at baseline compared WHC controls (4312 vs 0μm2 alizarin red area, p

Published
2017
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2. Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia

Author

Jesse Chait, Maryam Salehi, Alexei Y. Savinov, Omid J. Rashidbaigi, Olga V. Savinova, Filippo Romanelli, Manisha C. Yadav, Soha Salman, Kenneth B. Margulies, A. Martin Gerdes, David Petrosian, Jes Kuruvilla, AnthonyMarco Corbo, Maria M. Plummer, José Luis Millán, Ilian A. Radichev, and Anthony B. Pinkerton

Subjects
0301 basic medicine, Physiology, lcsh:Medicine, Alizarin Staining, Core Binding Factor Alpha 1 Subunit, Coronary Artery Disease, 030204 cardiovascular system & hematology, Vascular Medicine, Biochemistry, Ventricular Function, Left, Coronary artery disease, chemistry.chemical_compound, Mice, 0302 clinical medicine, Medicine and Health Sciences, Group-Specific Staining, Enzyme Inhibitors, lcsh:Science, Coronary Arteries, Cells, Cultured, Staining, Multidisciplinary, Arteries, Animal Models, Lipids, Coronary Vessels, Immunohistochemistry, 3. Good health, Arterial calcification, medicine.anatomical_structure, Experimental Organism Systems, Echocardiography, Alkaline phosphatase, Cytokines, Anatomy, Research Article, medicine.medical_specialty, Endothelium, Mouse Models, Mice, Transgenic, Biology, Research and Analysis Methods, Calcification, Hyperlipoproteinemia Type II, 03 medical and health sciences, Model Organisms, Calcification, Physiologic, Internal medicine, medicine, Oil Red O, Animals, Humans, Coronary atherosclerosis, Nutrition, Myocardium, Hematoxylin Staining, Body Weight, lcsh:R, Biology and Life Sciences, Endothelial Cells, medicine.disease, Atherosclerosis, Alkaline Phosphatase, Placebo Effect, Diet, Coronary arteries, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, chemistry, Receptors, LDL, Specimen Preparation and Treatment, Cardiovascular Anatomy, Blood Vessels, Diet, Atherogenic, lcsh:Q, Endothelium, Vascular, Physiological Processes, Blood Chemical Analysis
Abstract

Objective Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelium leads to arterial calcification in mice. The purpose of this study was to examine the effect of elevated endothelial TNAP on coronary atherosclerosis. In addition, we aimed to examine endogenous TNAP activity in human myocardium. Approach and results A vascular pattern of TNAP activity was observed in human non-failing, ischemic, and idiopathic dilated hearts (5 per group); no differences were noted between groups in this study. Endothelial overexpression of TNAP was achieved in mice harboring a homozygous recessive mutation in the low density lipoprotein receptor (whc allele) utilizing a Tie2-cre recombinase (WHC-eTNAP mice). WHC-eTNAP developed significant coronary artery calcification at baseline compared WHC controls (4312 vs 0μm2 alizarin red area, p

Published
2017

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