1. Childhood maltreatment and risk of endocrine diseases: an exploration of mediating pathways using sequential mediation analysis
- Author
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Shu Wen, Jianwei Zhu, Xin Han, Yuchen Li, Haowen Liu, Huazhen Yang, Can Hou, Shishi Xu, Junren Wang, Yao Hu, Yuanyuan Qu, Di Liu, Thor Aspelund, Fang Fang, Unnur A. Valdimarsdóttir, and Huan Song
- Subjects
Childhood maltreatment ,Endocrine diseases ,Sequential mediation analysis ,Psychological adversities ,Medicine - Abstract
Abstract Background Adverse childhood experiences (ACEs), including childhood maltreatment, have been linked with increased risk of diabetes and obesity during adulthood. A comprehensive assessment on the associations between childhood maltreatment and all major endocrine diseases, as well as the relative importance of different proposed mechanistic pathways on these associations, is currently lacking. Methods Based on the UK Biobank, we constructed a cohort including 151,659 participants with self-reported data on childhood maltreatment who were 30 years of age or older on/after January 1, 1985. All participants were followed from the index date (i.e., January 1, 1985, or their 30th birthday, whichever came later) until the first diagnosis of any or specific (12 individual diagnoses and 9 subtypes) endocrine diseases, death, or the end of follow-up (December 31, 2019), whichever occurred first. We used Cox models to examine the association of childhood maltreatment, treated as continuous (i.e., the cumulative number of experienced childhood maltreatment), ordinal (i.e., 0, 1 and ≥ 2), or binary (
- Published
- 2024
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