1. Is there any association between Serum anti-HSP27 antibody level and the presence of metabolic syndrome; population based case-control study
- Author
-
Elham Barati, Azam Rastgar Moghadam, Mahmoud Ebrahimi, Maryam Tayefi, Fatemeh Sadabadi, Mohammad Tayyebi, Alireza Heidari-Bakavoli, Susan Darroudi, Seyed Mohammad Reza Parizadeh, Narges Fereydouni, Gordon A. Ferns, Najmeh malekzadeh, S.J. Hosseini, Habibollah Esmaily, Kiana Hosseinpour Moghaddam, Shima Tavalaie, Mahmoud Reza Azarpazhooh, Amir Hosein Sahebkar, Zahra Asadi, Majid Ghayour-Mobarhan, and Mohsen Mouhebati
- Subjects
0301 basic medicine ,serum anti-hsp27 antibody ,endocrine system ,mashad study cohort ,animal structures ,Antibody level ,Population based ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,metabolic syndrome ,03 medical and health sciences ,0302 clinical medicine ,Hsp27 ,Human biology ,medicine ,biology ,business.industry ,Case-control study ,medicine.disease ,030104 developmental biology ,Immunology ,embryonic structures ,biology.protein ,Medicine ,Metabolic syndrome ,business - Abstract
Background: Heat shock protein 27 (HSP27) is an intracellular chaperone constitutively expressed in many cell types including cardio myocytes and endothelial cells. Circulating levels of HSP27 and anti-HSP27 antibody are higher in patients with CVD. Anti-HSP27 antibody concentrations were also reported to be increased in atherogenesis. We aimed to evaluate serum anti-HSP27 antibody titers in individuals with, or without, MetS in the MASHAD study cohort with large sample size in 6,568 subjects. Methods: Participants with MetS were identified from MASHAD cohort (n=3358) using the IDF criteria, and the control group were those individuals who did not meet these criteria (n=3210). In-house enzyme-linked immune sorbent assay (ELISA) method was used for measuring Anti-HSP27 antibody levels. The two groups were matched for age, sex and smoking habit. Results: As expected, there were significant differences in height (p= 0.004), waist and hip circumference, weight, BMI, systolic and diastolic blood pressure, TGs, TC, HDL-C, Hs-CRP, glucose, with the presence of diabetes mellitus, hypertension, hyperlipidemia (p Conclusion: In conclusion, our results revealed serum anti-HSP27 antibody titers were not statistically different between individuals with and without MetS. However, it is possible that drug treatment may affect antibody titers and confound our findings in this population sample..
- Published
- 2019