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3 results on '"Shengqiang Ye"'

1. A systematic review and meta-analysis of magnetic resonance and computed tomography enterography in the diagnosis of small intestinal tumors

Author

Ruitao Li, Shengqiang Ye, Chenglong Zhou, Feng Liu, and Xiaonan Li

Subjects
MR, CT enterography, Small intestinal tumor, Diagnosis, System evaluation, Medicine, Biology (General), QH301-705.5
Abstract

Objective To explore the potential value of magnetic resonance (MR) and computed tomography (CT) enterography in the diagnosis of small intestinal tumor (SIT). Methods Articles reporting on the diagnosis of SIT by MR and CT enterography deposited in Chinese and foreign literature databases were identified and evaluated using the quality assessment of diagnostic accuracy studies (QUADAS). The diagnostic data extracted from the articles were adopted for meta-analysis using Meta-disc 1.40 software. Analysis was undertaken to compare the sensitivity, specificity, positive and negative likelihood ratios, and the diagnostic odds ratio (DOR) of MR and CT enterography in the diagnosis of SIT. The diagnostic values of the two imaging methods were analyzed by summary receiver operating characteristic (SROC) curves. The meta-analysis was registered at INPLASY (202380053). Results A total of eight articles, including 551 cases of SIT were included in this analysis. The pooled sensitivity and specificity of MR enterography were 0.92 (95% CI [0.89–0.95]) and 0.81 (95% CI [0.74–0.86]), respectively, whilst CT enterography had a sensitivity of 0.93 (95% CI [0.90–0.95]) and a specificity of 0.83 (95% CI [0.76–0.88]). For MR enterography, the combined positive likelihood ratio was 4.90 (95% CI [3.50–6.70]), the combined negative likelihood ratio was 0.10 (95% CI [0.07–0.14]), and the area under the receiver operating characteristic curve (AUROC) was 0.940. For CT enterography, the corresponding values were 5.40 (95% CI [3.90–7.40]), 0.08 (95% CI [0.06–0.12]), and 0.950, respectively. When the pretest probability for MR was assumed to be 50%, the posterior probabilities for positive and negative results were calculated as 83% and 9%, respectively. For CT enterography with a pretest probability of 50%, the posterior probabilities of positive and negative results were 84% and 8%, respectively. Conclusion MR and CT enterography have high accuracy in the diagnosis of SIT and have a valuable role in the diagnosis and management of these tumors.

Published
2023
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2. The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2

Author

Qigai He, Hanchun Yang, Yi Guo, Xiabing Chen, Wentao Li, Weidong Yan, Jie Chen, Qian Yunguo, Shulin Fu, Shengqiang Ye, Shiyu Gong, and Jin Erguang

Subjects
Circovirus, 0301 basic medicine, Swine, animal diseases, medicine.medical_treatment, Intraperitoneal injection, Pharmacology, Antiviral Agents, Lignans, Mice, Random Allocation, 03 medical and health sciences, chemistry.chemical_compound, In vivo, medicine, Animals, Dosing, Circoviridae Infections, Medicine, Chinese Traditional, Furans, Arctigenin, Swine Diseases, Mice, Inbred BALB C, General Veterinary, biology, business.industry, Ribavirin, virus diseases, biology.organism_classification, In vitro, Arctium, Porcine circovirus, 030104 developmental biology, chemistry, Immunology, Arctium lappa, Female, business, Injections, Intraperitoneal
Abstract

Arctigenin (ACT) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb Arctium lappa L. (Compositae) with anti-viral and anti-inflammatory effects. Here, we investigated the antiviral activity of ACT found in traditional Chinese medicine on porcine circovirus type 2 (PCV2) in vitro and in vivo. Results showed that dosing of 15.6-62.5μg/mL ACT could significantly inhibit the PCV2 proliferation in PK-15 cells (P

Published
2016

3. Development and validation of an indirect competitive enzyme-linked immunosorbent assay for the screening of tylosin and tilmicosin in muscle, liver, milk, honey and eggs

Author

Zhenli Liu, Yanfei Tao, Xiaoqing Wang, Zonghui Yuan, Dapeng Peng, Dongmei Chen, Menghong Dai, Lingli Huang, Yulian Wang, and Shengqiang Ye

Subjects
Meat, medicine.drug_class, Coefficient of variation, Eggs, Enzyme-Linked Immunosorbent Assay, Food Contamination, Tylosin, Monoclonal antibody, High-performance liquid chromatography, chemistry.chemical_compound, Mice, medicine, Animals, Tilmicosin, Muscle, Skeletal, Detection limit, Mice, Inbred BALB C, Chromatography, Sheep, Fishes, General Chemistry, Honey, Anti-Bacterial Agents, Milk, chemistry, Liver, Monoclonal, Cattle, Female, General Agricultural and Biological Sciences, Hapten, Chickens
Abstract

Incorrect use of tylosin and tilmicosin could result in allergy and select resistance. To monitor the illegal use of these antibiotics in animals, a monoclonal-based indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) has been established. Several haptens were synthesized and conjugated to carrier protein. Female Balb/c mice were inoculated with the four different conjugates to produce monoclonal antibodies according to the schemes of immunization. Aftercell fusion and culture several times, nine hybridoma cell lines were isolated. Only one, 3C4 that has isotype IgG2a, was selected for detailed study. The cross-reactivity of the monoclonal antibody 3C4 to tylosin and tilmicosin was 100% and 51% respectively. The standard curves based on the tylosin and tilmicosin matrix calibration ranged from 2.5 to 40 μg L(-1), with an IC(50) value of 6.1 μg L(-1) and 12.1 μg L(-1), respectively. The limits of detection of the ic-ELISA ranged from 5.1 μg kg(-1) to 13.8 μg kg(-1) in edible animal tissues. The recoveries were 74.1% to 120.7% with less than 18.6% of the coefficient of variation when tylosin and tilmicosin were spiked in various biological matrices with the concentrations of 25.0-200.0 μg kg(-1). Good correlations between the results of the ic-ELISA and high performance liquid chromatography were observed in the incurred tissues. These results suggest that the ic-ELISA is a sensitive, accurate and low-cost method that would be a useful tool for the screening of the residues of tylosin and tilmicosin in muscle, liver, milk, honey and eggs.

Published
2011

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