1. A systematic literature review and network meta-analysis feasibility study to assess the comparative efficacy and comparative effectiveness of pneumococcal conjugate vaccines
- Author
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Janneke Luijken, Rachel S. Newson, Patricia Izurieta, Shehzad M. Iqbal, Josefine Redig, Ashleigh McGirr, and Carla Talarico
- Subjects
Cost-Benefit Analysis ,Network Meta-Analysis ,030231 tropical medicine ,Immunology ,medicine.disease_cause ,invasive pneumococcal disease ,Pneumococcal Infections ,Pneumococcal conjugate vaccine ,Haemophilus influenzae ,Pneumococcal Vaccines ,03 medical and health sciences ,0302 clinical medicine ,systematic review ,Conjugate vaccine ,medicine ,Humans ,Immunology and Allergy ,030212 general & internal medicine ,Vaccine Potency ,Randomized Controlled Trials as Topic ,Pharmacology ,Vaccines, Conjugate ,business.industry ,Infant ,comparative efficacy or effectiveness ,Systematic review ,Case-Control Studies ,Child, Preschool ,Meta-analysis ,Feasibility Studies ,business ,Research Paper ,feasibility ,medicine.drug ,Conjugate - Abstract
Background: No head-to-head studies are currently available comparing pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) with 13-valent pneumococcal conjugate vaccine (PCV-13). This study explored the feasibility of using network meta-analysis (NMA) to conduct an indirect comparison of the relative efficacy or effectiveness of the two vaccines. Methods: A systematic literature search was conducted for published randomized controlled trials (RCTs) and non-RCT studies reporting data on vaccine efficacy or effectiveness against invasive pneumococcal disease in children aged
- Published
- 2019