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Late onset Alzheimer's disease (AD) and Parkinson's disease (PD) are mostly "sporadic" age-related neurodegenerative disorders, but with a clear genetic component. However, their genetic architecture is complex and heterogeneous, largely remaining a conundrum, with only a handful of well-established genetic risk factors consistently associated with these diseases. It is possible that numerous, yet undiscovered, AD and PD related genes might exist. We focused on the 'gene' as a mediator to find new potential genes that might have a relationship with both disorders using bio-literature mining techniques. Based on Entrez Gene, we extracted the genes and directional gene-gene relation in the entire MEDLINE records and then constructed a directional gene-gene network. We identified common genes associated with two different but related diseases by performing shortest path analysis on the network. With our approach, we were able to identify and map already known genes that have a direct relationship with PD and AD. In addition, we identified 7 genes previously unknown to be a bridge between these two disorders. We confirmed 4 genes, ROS1, FMN1, ATP8A2, and SNORD12C, by biomedical literature and further checked 3 genes, ERVK-10, PRS, and C7orf49, that might have a high possibility to be related with both diseases. Additional experiments were performed to demonstrate the effectiveness of our proposed method. Comparing to the co-occurrence approach, our approach detected 25% more candidate genes and verified 10% more genes that have the relationship between both diseases than the co-occurrence approach did.

Purpose: The purpose of this study was to test the change of study variables (knowledge, efficacy, and fatigue) related to using orthosis and fear of falling in fracture patients wearing the leg orthosis after fall prevention education in terms of educational method and frequency. Methods: Participants were 87 fracture patients wearing the leg orthosis. Experimental I group (n

In this report, we described a very rare type of patient with micropapillary thyroid carcinoma with macronodular lung metastasis that had prolonged growth arrest for more than 8 years without any treatment. Unlike previous reports with stable metastasis, the patient presented here was older than prior cases and had a smaller size of the primary carcinoma.

Background During a golf swing, analysis of the movement in upper torso and pelvis is a key step to determine a motion control strategy for accurate and consistent shots. However, a majority of previous studies that have evaluated this movement limited their analysis only to the rotational movement of segments, and translational motions were not examined. Therefore, in this study, correlations between translational motions in the 3 axes, which occur between the upper torso and pelvis, were also examined. Methods The experiments were carried out with 14 male pro-golfers (age: 29 ± 8 years, career: 8.2 ± 4.8years) who registered in the Korea Professional Golf Association (KPGA). Six infrared cameras (VICON; Oxford Metrics, Oxford, UK) and SB-Clinc software (SWINGBANK Ltd, Korea) were used to collect optical marker trajectories. The center of mass (CoM) of each segment was calculated based on kinematic principal. In addition, peak value of CoM velocity and the time that each peak occurred in each segment during downswing was calculated. Also, using cross-correlation analysis, the degree of coupling and time lags of peak values occurred between and within segments (pelvis and upper torso) were investigated. Results As a result, a high coupling strength between upper torso and pelvis with an average correlation coefficient = 0.86 was observed, and the coupling between segments was higher than that within segments (correlation coefficient = 0.81 and 0.77, respectively). Conclusions Such a high coupling at the upper torso and pelvis can be used to reduce the degree of motion control in the central nervous system and maintain consistent patterns in the movement. The result of this study provides important information for the development of optimal golf swing movement control strategies in the future.

CT remains the optimal imaging modality for diagnosing cystic and solid masses in the mesentery. CT may provide important information regarding the lesion's location, size and shape, the presence and thickness of a wall, the presence of septa, calcifications or fat, and the involvement of adjacent structures. Although percutaneous imaging-guided or surgical biopsy is often necessary to guide medical management, analysis of the CT features along with the clinical history may be helpful in differentiating mesenteric masses, including cystic lesions and primary neoplasms arising from the mesenchymal tissues or the secondary metastatic lesions. CT is useful not only for detecting cystic and solid mesenteric masses, but also for helping physicians become familiar with the features of various mesenteric masses for accurate diagnosis and treatment.

A patient of cerebral sparganosis is reported : The patient, a 47-year-old female complained of frequent seizures and headache. The disease was involved on right frontal lobe, and the lesion was successfully removed by BRW stereotaxic system. The characteristic features of sparganosis are reviewed.

The incidence of multiple meningiomas found prior to the introduction of CT was 1~2%, the incidence since the introduction of CT was 8.9%. The authous report a case of multiple meningiomas without evidence of von Recklinghausen's disease. The possible presence of more than 1 tumor in a patient with an intracranial meningiomas must always be kept in mind. The pathogenetic factors related to true multiple meningiomas is unknown. We report a patient with multiple meningiomas which was confirmed by operation.