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Your search keyword '"Service d'anatomie pathologique et de neurophatologie"' showing total 2 results
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2 results on '"Service d'anatomie pathologique et de neurophatologie"'

1. Fibronectin expression in glioblastomas promotes cell cohesion, collective invasion of basement membrane in vitro and orthotopic tumor growth in mice

Author

Franck Debarbieux, Geneviève Rougon, Dominique Grall, E Serres, Dominique Figarella-Branger, Thierry Virolle, Fabio Stanchi, Laurent Turchi, Laurence Maggiorella, E Van Obberghen-Schilling, Fanny Burel-Vandenbos, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Vectorologie et transfert de gènes (VTG / UMR8121), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Institut de signalisation, biologie du développement et cancer (ISBDC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Physiopathologie et biothérapie: cellules souches, développement et cancer, Institut National de la Santé et de la Recherche Médicale (INSERM), IFR50, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Faculté de Médecine Nice, Service d'anatomie pathologique et de neurophatologie, Assistance Publique - Hôpitaux de Marseille (APHM)-CHU Marseille, Centre de référence des maladies rares neuromusculaires, Université Nice Sophia Antipolis (1965 - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)

Subjects
Cancer Research, Angiogenesis, Cell Survival, Cell, Motility, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Basement Membrane, Small hairpin RNA, Extracellular matrix, Mice, Cell Movement, Spheroids, Cellular, Genetics, medicine, Cell Adhesion, Tumor Cells, Cultured, Animals, Humans, Protein Isoforms, Neoplasm Invasiveness, RNA, Small Interfering, Cell adhesion, Molecular Biology, Cell Proliferation, Neovascularization, Pathologic, Cell growth, Extracellular Matrix, Fibronectins, Fibronectin, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Immunology, biology.protein, Cancer research, RNA Interference, Glioblastoma, Integrin alpha5beta1
Abstract

International audience; : Glioblastoma multiforme (GBM) are highly invasive and angiogenic malignancies with a median survival time from diagnosis of

Published
2013
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2. Immunolabelling and flow cytometry as new tools to explore dysferlinopathies

Author

C. Fossat, Karine Nguyen, Emmanuelle Salort-Campana, Nicolas Lévy, Jean Pouget, Danielle Depetris, Nicolas Wein, F. Leturcq, Pierre Cau, C Fernandez, Martin Krahn, Marc Bartoli, Sébastien Courrier, Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Center for Advanced Studies, Research and Development in Sardinia (CRS4), Génétique Médicale et Génomique Fonctionnelle (GMGF), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de génétique médicale [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'anatomie pathologique et de neurophatologie, Assistance Publique - Hôpitaux de Marseille (APHM)-CHU Marseille, Centre de référence des maladies rares neuromusculaires, Centre de résonance magnétique biologique et médicale (CRMBM), and Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Pathology, medicine.medical_specialty, Blotting, Western, Fluorescent Antibody Technique, Muscle Proteins, Biology, Immunofluorescence, Antibodies, Monocytes, Muscular Dystrophies, Flow cytometry, Dysferlin, 03 medical and health sciences, 0302 clinical medicine, Western blot, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Muscle, Skeletal, Genetics (clinical), 030304 developmental biology, Whole blood, 0303 health sciences, Muscle biopsy, medicine.diagnostic_test, Membrane Proteins, Flow Cytometry, Molecular biology, Immunohistochemistry, 3. Good health, Blot, Neurology, Pediatrics, Perinatology and Child Health, Mutation, biology.protein, Neurology (clinical), Antibody, 030217 neurology & neurosurgery
Abstract

International audience; Dysferlinopathies are autosomal recessive muscular dystrophies caused by DYSF mutations, Which lead to a reduced amount or a complete lack of dysferlin. One step in dysferlinopathies diagnosis consists in Western blot analysis of proteins extracted from Muscle biopsy, or blood monocytes. We have taken advantage of dysferlin expression in monocytes to develop a whole blood flow cytometry (WBFC), using antibodies directed against dysferlin. Six patients were submitted to WBFC analysis and immunofluorescence analysis oil monocytes. Results obtained are correlated to Western blot from monocytes and muscle biopsies. The possible usefulness of this flow cytometry analysis in routine diagnosis is presented. (C) 2009 Elsevier B.V. All rights reserved.

Published
2010
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