26 results on '"Sang Jun Byun"'
Search Results
2. YWHAZ and TBP are potential reference gene candidates for qPCR analysis of response to radiation therapy in colorectal cancer
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Shin Kim, Jee Young Park, Hye Won Lee, Sung Uk Bae, Kyeong Eui Kim, Sang Jun Byun, and Incheol Seo
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Medicine ,Science - Abstract
Abstract The expression profiles of conventional reference genes (RGs), including ACTB and GAPDH, used in quantitative real-time PCR (qPCR), vary depending on tissue types and environmental conditions. We searched for suitable RGs for qPCR to determine the response to radiotherapy in colorectal cancer (CRC) cell lines, organoids, and patient-derived tissues. Ten CRC cell lines (Caco-2, COLO 205, DLD-1, HCT116, HCT-15, HT-29, RKO, SW1116, SW480, and SW620) and organoids were selected and irradiated with 2, 10 or 21 grays (Gy) based on the previous related studies conducted over the last decade. The expression stability of 14 housekeeping genes (HKGs; ACTB, B2M, G6PD, GAPDH, GUSB, HMBS, HPRT1, IPO8, PGK1, PPIA, TBP, TFRC, UBC, and YWHAZ) after irradiation was evaluated using RefFinder using raw quantification cycle (Cq) values obtained from samples before and after irradiation. The expression stability of HKGs were also evaluated for paired fresh frozen tissues or formalin-fixed, paraffin-embedded samples obtained from CRC patients before and after chemoradiotherapy. The expression of YWHAZ and TBP encoding 14-3-3-zeta protein and TATA-binding protein were more stable than the other 12 HKGs in CRC cell lines, organoids, and patient-derived tissues after irradiation. The findings suggest that YWHAZ and TBP are potential RG candidates for normalizing qPCR results in CRC radiotherapy experiments.
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- 2023
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3. Elective pelvic irradiation in prostate cancer patients with biochemical failure following radical prostatectomy: A propensity score matching analysis.
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Changhoon Song, Sang Jun Byun, Young Seok Kim, Hanjong Ahn, Seok-Soo Byun, Choung-Soo Kim, Sang Eun Lee, and Jae-Sung Kim
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Medicine ,Science - Abstract
PurposeTo investigate whether whole pelvic radiotherapy (WPRT) improves biochemical relapse-free survival (bRFS) vs. prostate bed radiotherapy (PBRT) in prostate cancer patients receiving salvage radiotherapy (SRT) after radical prostatectomy.MethodsData from patients with prostate cancer who underwent SRT for biochemical recurrence between 2005 and 2012 in two academic institutions were retrospectively reviewed. Patients treated with WPRT in one hospital were compared with patients treated with PBRT in the other. Propensity scoring was performed to balance the characteristics of the different treatment groups, and bRFS was compared.ResultsData from a total of 191 patients were included in the analysis (WPRT, n = 108; PBRT, n = 83). The median follow-up period was 66 months. Prior to matching, patients who received WPRT had higher pathologic Gleason scores as well as a higher incidence of pre-SRT PSA levels >0.5 ng/mL and lower rates of concurrent androgen-deprivation therapy. Propensity score matching balanced these characteristics and generated a cohort comprising 56 patients from each group. In the matched cohort, the 5 year bRFS of the WPRT group was significantly higher than that of the PBRT group (65.9 vs. 42.2%, p = 0.017). Multivariate analysis revealed that WPRT was an independent prognostic factor for bRFS (hazard ratio: 0.45, 95% confidence interval: 0.26-0.75, p = 0.002). This benefit of WPRT on bRFS was maintained in subgroup analyses, especially in patients with preoperative PSA level ≤20 ng/mL or pre-SRT PSA level ≥0.4 ng/mL.ConclusionsThese data suggest that, following radical prostatectomy, elective WPRT during SRT may improve bRFS compared with PBRT in selected patients. Patients with preoperative PSA level ≤20 ng/mL or pre-SRT PSA level ≥0.4 ng/mL represent a potential subgroup who benefit most from receiving WPRT. Results of prospective randomized trials are awaited to confirm this finding.
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- 2019
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4. A multi-institutional study of bladder-preserving therapy for stage II-IV bladder cancer: A Korean Radiation Oncology Group Study (KROG 14-16).
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Sang Jun Byun, Won Park, Kwan Ho Cho, Jaeho Cho, Ah Ram Chang, Ki Mun Kang, Jin Ho Kim, and Jin Hee Kim
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Medicine ,Science - Abstract
BackgroundAlthough radical cystectomy is a standard treatment in muscle-invasive bladder cancer, bladder preservation therapy including transurethral resection of bladder tumor, radiotherapy, and concurrent chemotherapy has been widely adopted, recently. This retrospective analysis was performed to evaluate the survival rates and prognostic factors related to treatment outcomes following bladder-preserving therapy including radiotherapy (RT) in bladder cancer with a curative intent.Materials and methodsWe conducted a multi-institutional retrospective study of 152 patients with stage II-IV bladder cancer treated with curative RT between 2000 and 2010. There were 72 patients in stage II, 49 in stage III, and 31 in stage IV. Ninety-seven patients were treated with concurrent chemoradiotherapy and fifty-five with RT alone. Radiation was delivered to the pelvis (median 63 Gy), mainly with cisplatin. The median follow-up time was 35.5 months.ResultsSixty-nine patients (45.4%) showed a complete response to RT. The 5-year overall survival (OS) rate was 45.8%, the 5-year cause-specific survival (CSS) rate was 48.9%, and the 5-year disease-free survival (DFS) rate was 20.8%. Univariate analysis revealed significant differences in the following factors according to the survival rates: patient age, initial hemoglobin level, clinical T stage, clinical N stage, clinical stage group, tumor response to RT, hydronephrosis, and concurrent chemotherapy. Multivariate analysis also revealed a significant difference in patient age (p = 0.003 in OS, pConclusionsThe survival rates reported herein are comparable to those from other studies, and tumor response and concurrent chemoradiotherapy were significant prognostic factors for better survival rates. Further randomized studies are needed to elucidate the impact of RT in bladder cancer.
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- 2019
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5. Image-guided, whole-pelvic, intensity-modulated radiotherapy for biochemical recurrence following radical prostatectomy in high-risk prostate cancer patients.
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Sang Jun Byun, Young Seok Kim, Hanjong Ahn, and Choung-Soo Kim
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Medicine ,Science - Abstract
The optimal field size of salvage radiotherapy (SRT) for biochemical recurrence, particularly for patients with high-risk prostate cancer, remains undefined. This retrospective analysis was performed to investigate oncological outcomes as well as treatment-related toxicity following salvage intensity-modulated radiotherapy (IMRT) to the whole pelvis and to compare the results with other studies implementing a small field size of the prostate bed.The medical records of 170 patients with high-risk prostate cancer who received SRT for biochemical recurrence following prostatectomy were reviewed. Whole-pelvic IMRT was administered with a median dose of 66 Gy in 30 fractions. To improve treatment accuracy, an endorectal balloon device and daily cone-beam computed tomography were utilized. Androgen-deprivation therapy combined with SRT was administered to 97 (57.1%) patients.Eventually, 68 (40.0%) patients showed biochemical progression (BCP) after SRT. With a median follow-up period of 56 months, the 5-year BCP-free survival was 38.6%. The overall and cause-specific survival rates were 90.9% and 96.7%, respectively. Regarding BCP-free survival analysis, pathological T stage, persistent prostate-specific antigen (PSA) elevation after prostatectomy, and preSRT PSA level were significant prognostic factors on univariate analysis. On multivariate analysis, pathological T stage and preSRT PSA value retained their significance. Acute and late grade-3 genitourinary toxicities were observed in one (0.6%) and five (2.9%) patients, respectively. One patient each developed acute and late grade-3 gastrointestinal toxicity.SRT to whole pelvis using IMRT and image guidance is as safe as SRT to the prostate bed, but its efficacy should be confirmed in ongoing randomized trials. PreSRT PSA was the only controllable prognostic factor, suggesting the benefit of early SRT.
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- 2018
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6. Polo-like kinase 4 as a potential predictive biomarker of chemoradioresistance in locally advanced rectal cancer
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Ilseon Hwang, Sung Uk Bae, Soon Gu Kim, Jae-Ho Lee, Sun Young Kwon, Sang Jun Byun, Hyunseung Oh, Shin Kim, and Hye Won Lee
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Tumor Regression Grade ,Oncology ,medicine.medical_specialty ,Histology ,medicine.diagnostic_test ,business.industry ,Colorectal cancer ,Retrospective cohort study ,Cell cycle ,medicine.disease ,rectal neoplasms ,chemoradiotherapy ,Pathology and Forensic Medicine ,polo-like kinase 4 ,Internal medicine ,Biopsy ,Pathology ,medicine ,biomarker ,RB1-214 ,Immunohistochemistry ,Biomarker (medicine) ,Original Article ,business ,Chemoradiotherapy - Abstract
Background: Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase located in the centriole of the chromosome during the cell cycle. PLK4 overexpression has been described in a variety of many common human epithelial tumors. Conversely, PLK4 acts as a haploinsufficient tumor suppressor in some situations, highlighting the importance of strict regulation of PLK4 expression, activity, and function. Meanwhile, the importance of chemoradiation resistance in rectal cancer is being emphasized more than ever. We aimed to analyze PLK4 expression and the tumor regression grade (TRG) in patients with rectal cancer, treated with chemoradiotherapy (CRT).Methods: A retrospective study was conducted on 102 patients with rectal cancer who received preoperative CRT. Immunohistochemistry for PLK4 in paraffin-embedded tissue was performed from the biopsy and surgical specimens. Results: We found significant association between high expression of PLK4 and poor response to neoadjuvant CRT (according to both Mandard and The Korean Society of Pathologists TRG systems) in the pre-CRT specimens. Other clinicopathologic parameters did not reveal any correlation with PLK4 expression. Conclusions: This study revealed an association between high expression of PLK4 in the pre-CRT specimens and TRG. Our results indicated that PLK4 could potentially be a new predictor for CRT effect in patients with rectal cancer.
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- 2022
7. Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
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Hye Won Lee, Hasong Jeong, Sung Uk Bae, Sang Jun Byun, Sun Young Kwon, Shin Kim, Hyeong Chan Shin, and Incheol Seo
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Oncology ,medicine.medical_specialty ,Colorectal cancer ,Science ,CD11c ,colorectal cancer ,Article ,General Biochemistry, Genetics and Molecular Biology ,Internal medicine ,medicine ,Overall survival ,tumor microenvironment ,Ecology, Evolution, Behavior and Systematics ,Tumor microenvironment ,CD68 ,business.industry ,tumor-associated macrophages ,Paleontology ,Distant metastasis ,medicine.disease ,Space and Planetary Science ,Immunohistochemistry ,prognosis ,business ,CD163 - Abstract
This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgical resection between September 1999 and August 2004. A high proportion of CD68-positive macrophages were associated with the occurrence of distant metastasis. A low proportion of CD11c-positive macrophages were associated with unfavorable overall survival (OS) and disease-free survival. CD11c-positive macrophages were found to act as independent prognostic factors for OS. An analysis of our long-term data indicated that TAMs are significantly associated with OS and prognosis in CRC.
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- 2021
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8. Neoadjuvant chemoradiation alters biomarkers of anticancer immunotherapy responses in locally advanced rectal cancer
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Jee Young Park, Hyeonji Min, Sung Hwan Lee, Sang Jun Byun, Sung Uk Bae, Ju Seog Lee, Hye Won Lee, Incheol Seo, and Shin Kim
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0301 basic medicine ,Oncology ,Cancer Research ,Time Factors ,genetic structures ,Colorectal cancer ,medicine.medical_treatment ,immunomodulation ,0302 clinical medicine ,Databases, Genetic ,Immunotherapy Biomarkers ,Tumor Microenvironment ,Immunology and Allergy ,Medicine ,Gene Regulatory Networks ,RNA-Seq ,RC254-282 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Neoadjuvant Therapy ,Gene Expression Regulation, Neoplastic ,Treatment Outcome ,030220 oncology & carcinogenesis ,Radioimmunotherapy ,Molecular Medicine ,Biomarker (medicine) ,medicine.medical_specialty ,Immunology ,Adenocarcinoma ,03 medical and health sciences ,Internal medicine ,Biomarkers, Tumor ,Humans ,radiotherapy ,Pharmacology ,business.industry ,Rectal Neoplasms ,Gene Expression Profiling ,Cancer ,Microsatellite instability ,Immunotherapy ,Chemoradiotherapy, Adjuvant ,medicine.disease ,HCT116 Cells ,genome instability ,Radiation therapy ,Gene expression profiling ,030104 developmental biology ,radioimmunotherapy ,business ,Transcriptome - Abstract
BackgroundNeoadjuvant chemoradiation therapy (CRT) is a widely used preoperative treatment strategy for locally advanced rectal cancer (LARC). However, a few studies have evaluated the molecular changes caused by neoadjuvant CRT in these cancer tissues. Here, we aimed to investigate changes in immunotherapy-related immunogenic effects in response to preoperative CRT in LARC.MethodsWe analyzed 60 pairs of human LARC tissues before and after irradiation from three independent LARC cohorts, including a LARC patient RNA sequencing (RNA-seq) dataset from our cohort and GSE15781 and GSE94104 datasets.ResultsGene ontology analysis showed that preoperative CRT significantly enriched the immune response in LARC tissues. Moreover, gene set enrichment analysis revealed six significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways associated with downregulated genes, including mismatch repair (MMR) genes, in LARC tissues after CRT in all three cohorts. Radiation also induced apoptosis and downregulated various MMR system-related genes in three colorectal cancer cells. One patient with LARC showed a change in microsatellite instability (MSI) status after CRT, as demonstrated by the loss of MMR protein and PCR for MSI. Moreover, CRT significantly increased tumor mutational burden in LARC tissues. CIBERSORT analysis revealed that the proportions of M2 macrophages and CD8 T cells were significantly increased after CRT in both the RNA-seq dataset and GSE94104. Notably, preoperative CRT increased various immune biomarker scores, such as the interferon-γ signature, the cytolytic activity and the immune signature.ConclusionsTaken together, our findings demonstrated that neoadjuvant CRT modulated the immune-related characteristics of LARC, suggesting that neoadjuvant CRT may enhance the responsiveness of LARC to immunotherapy.
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- 2021
9. PIBF1 suppresses the ATR/CHK1 signaling pathway and promotes proliferation and motility of triple-negative breast cancer cells
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Seung-Ho Heo, Seung-Hee Ryu, Sang-wook Lee, Sang Jun Byun, Jewon Ryu, Eun-Young Park, In-Jeoung Baek, Byung Ho Son, Eun Ji Ro, and Kang Hyun Kim
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0301 basic medicine ,Cancer Research ,Motility ,Mice, Nude ,Apoptosis ,Triple Negative Breast Neoplasms ,Ataxia Telangiectasia Mutated Proteins ,Biology ,Pregnancy Proteins ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Breast cancer ,Cell Movement ,medicine ,Biomarkers, Tumor ,Suppressor Factors, Immunologic ,Tumor Cells, Cultured ,Animals ,Humans ,Viability assay ,Triple-negative breast cancer ,Cell Proliferation ,Gene knockdown ,Mice, Inbred BALB C ,medicine.disease ,030104 developmental biology ,Oncology ,Cell culture ,030220 oncology & carcinogenesis ,Gene Knockdown Techniques ,Checkpoint Kinase 1 ,Cancer research ,Heterografts ,Female ,Signal transduction ,Signal Transduction - Abstract
This study evaluates the oncogenic role of PIBF1 in triple-negative breast cancer (TNBC). TNBC is considered to have a poorer prognosis than other types of breast cancer and is associated with high risk of recurrence and distant metastasis. Currently, there are no effective therapies for the TNBC patients with distant metastasis due to the lack of targeted therapeutic options. The effects of PIBF1 knockdown on the cell viability and motility of TNBC cell lines were investigated. Effects of PIBF1 overexpression on tumorigenicity and cell motility were confirmed using Ba/F3 cell line and xenograft study on BALB/c nude mice. In TNBC cell lines that highly express PIBF1, knockdown of PIBF1 induces apoptosis and suppresses cell viability and motility with activation of the ATR/CHK1 signaling pathway. Moreover, the oncogenic function of PIBF1 was confirmed using the Ba/F3 cell line. For the first time, these findings clarify the role of PIBF1 in regulating ATR/CHK1 signaling pathway and inhibiting the proliferation and migration of TNBC cell lines. These results demonstrate the oncogenic roles of PIBF1 and provide new insights into the function and the molecular mechanism of PIBF1 in malignant TNBC.
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- 2020
10. Dose comparison between prescription methods according to anatomical variations in intracavitary brachytherapy for cervical cancer
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Jae Ho Kim, Jinhee Kim, Sang Jun Byun, Ok Bae Kim, Euncheol Choi, and Young Kee Oh
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Uterine cervical neoplasms ,medicine.medical_treatment ,Brachytherapy ,Rectum ,Variation ,Bladder distension ,030218 nuclear medicine & medical imaging ,Radiation dosage ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,Clinical Investigation ,Cervical cancer ,business.industry ,Dose comparison ,Intracavitary brachytherapy ,medicine.disease ,Circumference ,digestive system diseases ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Original Article ,Anatomy ,business ,Nuclear medicine - Abstract
Purpose We compared how doses delivered via two-dimensional (2D) intracavitary brachytherapy (ICBT) and three-dimensional (3D) ICBT varied anatomically. Materials and Methods A total of 50 patients who received 30 Gy of 3D ICBT after external radiotherapy (RT) were enrolled. We compared the doses of the actual 3D and 2D ICBT plans among patients grouped according to six anatomical variations: differences in a small-bowel V2Gy, small bowel circumference, the direction of bladder distension, bladder volume, sigmoid V3.5Gy, and sigmoid circumference. Seven dose parameters were measured in line with the EMBRACE recommendations. Results In terms of bladder volume, the bladder and small-bowel D2cc values were lower in the 150–250 mL bladder volume subgroup; and the rectum, sigmoid, and bladder D2mL values were all lower in the >250 mL subgroup, for 3D vs. 2D ICBT. In the sigmoid V3.5Gy >2 mL subgroup, the sigmoid and bladder D2mL values were significantly lower for 3D than 2D ICBT. The bladder D2mL value was also significantly lower for 3D ICBT, as reflected by the sigmoid circumference. In patients with a small bowel V2.0Gy >10 mL or small bowel circumference >15%, most dose parameters were significantly lower for 3D than 2D ICBT. The bladder distension direction did not significantly affect the doses. Conclusion Compared to 2D ICBT, a greater bladder volume can reduce the internal 3D ICBT organ dose without affecting the target dose.
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- 2018
11. Postoperative radiotherapy appeared to improve the disease free survival rate of patients with extrahepatic bile duct cancer at high risk of loco-regional recurrence
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Jinhee Kim, Mi Young Kim, Sang Jun Byun, and Yong Hoon Kim
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medicine.medical_specialty ,Disease free survival ,Survival ,Lymphovascular invasion ,medicine.medical_treatment ,Postoperative radiotherapy ,Extrahepatic bile duct cancer ,Gastroenterology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Clinical Investigation ,Postoperative ,Survival rate ,Radiotherapy ,Bile duct ,business.industry ,Cancer ,medicine.disease ,Radiation therapy ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Original Article ,business - Abstract
Purpose To investigate the outcomes of postoperative radiotherapy (RT), in patients with extrahepatic bile duct (EHBD) cancer by comparing the survival rate between patients undergoing surgery alone or surgery plus postoperative RT, and to identify the prognostic factors affecting survival. Materials and methods Between 2000 and 2013, 52 patients with EHBD cancer underwent surgical resection. Of these, 33 patients did not receive postoperative RT (group I), and 19 patients did (group II). R1 resection was significantly more frequent in group II. The median radiation dose was 5,040 cGy. Results The 3-year overall survival (OS) rate for group I and group II was 38% and 56%, respectively (p = 0.274). The 3-year disease free survival (DFS) rate for group I and group II was 20% and 31%, respectively (p = 0.049), and the 3-year loco-regional recurrence free survival (LRFS) rates were 19% and 58%, respectively (p = 0.002). Multivariate analyses showed that postoperative RT and lymphovascular invasion were independent prognostic factors for DFS and LRFS. Overall, 42 patients (80%) experienced treatment failure. Distant metastasis was the predominant pattern of failure in group II. Conclusion Postoperative RT after surgical resection appeared to improve the loco-regional control and DFS rate. More effort is needed to reduce distant metastasis, the major pattern of failure, in patients who receive postoperative RT.
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- 2016
12. Abstract 475: Preoperativechemoradiation increases levels of immune system modulators in tumor tissue in locally advanced rectal cancer
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SungUk Bae, Sang Jun Byun, Jee Young Park, Shin Kim, Hyeonji Min, and Hye Won Lee
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Oncology ,Cancer Research ,medicine.medical_specialty ,Mutation ,genetic structures ,business.industry ,Colorectal cancer ,medicine.medical_treatment ,Cancer ,Immunotherapy ,medicine.disease_cause ,medicine.disease ,Transcriptome ,Immune system ,Internal medicine ,Gene expression ,medicine ,DNA mismatch repair ,business - Abstract
Purpose: Neoadjuvant chemoradiation therapy (CRT) is a widely and effectively used preoperative treatment strategy in locally advanced rectal cancers. However, little research has been done to characterize the molecular changes caused by neoadjuvant CRT in these cancer tissues. The purpose of this study was to investigate the effects of preoperative CRT on tumor gene expression in Korean patients with colorectal cancer (CRC). Materials and methods: We included 11 paired human rectal cancer tissues before and after irradiation between August 2016 and December 2017, and performed RNA sequencing analysis. Principal component analysis of CRC demonstrated strong similarity in respective groups of CRC tissues before and after CRT from CRC patients at the transcriptome level. Results: Volcano plot filtering identified 3325 differentially expressed genes (DEGs) in CRC tissues after CRT, compared to CRC tissues before CRT. Gene set enrichment analysis with DEGs revealed 45 signaling pathways associated with down-regulated target genes, significantly including the mismatch repair signaling pathway. CRT significantly increased tumor mutation burden (TMB) in CRC tissues. Notably, preoperative CRT increased immune signature scores including interferon-gamma, immune cytolytic score, and immune signature. Conclusion: Neoadjuvant CRT modulates immune-related characteristics of CRC, including increasing TMB and various immune signature scores, suggesting that neoadjuvant CRT has potential to improve responsiveness to immunotherapy. Citation Format: SungUk Bae, Shin Kim, Hye Won Lee, Sang Jun Byun, Jee Young Park, Hyeonji Min. Preoperativechemoradiation increases levels of immune system modulators in tumor tissue in locally advanced rectal cancer [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 475.
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- 2020
13. Elective pelvic irradiation in prostate cancer patients with biochemical failure following radical prostatectomy: A propensity score matching analysis
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Hanjong Ahn, Changhoon Song, Young Seok Kim, Choung Soo Kim, Sang Eun Lee, Seok-Soo Byun, Sang Jun Byun, and Jae Sung Kim
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Biochemical recurrence ,Male ,medicine.medical_specialty ,Science ,medicine.medical_treatment ,030232 urology & nephrology ,Urology ,Salvage therapy ,Pelvis ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,medicine ,Humans ,Survival rate ,Aged ,Retrospective Studies ,Prostatectomy ,Salvage Therapy ,Multidisciplinary ,business.industry ,Hazard ratio ,Prostatic Neoplasms ,Retrospective cohort study ,Radiotherapy Dosage ,Middle Aged ,medicine.disease ,Prognosis ,Survival Rate ,030220 oncology & carcinogenesis ,Propensity score matching ,Medicine ,Radiotherapy, Intensity-Modulated ,Neoplasm Recurrence, Local ,Radiotherapy, Conformal ,business - Abstract
PurposeTo investigate whether whole pelvic radiotherapy (WPRT) improves biochemical relapse-free survival (bRFS) vs. prostate bed radiotherapy (PBRT) in prostate cancer patients receiving salvage radiotherapy (SRT) after radical prostatectomy.MethodsData from patients with prostate cancer who underwent SRT for biochemical recurrence between 2005 and 2012 in two academic institutions were retrospectively reviewed. Patients treated with WPRT in one hospital were compared with patients treated with PBRT in the other. Propensity scoring was performed to balance the characteristics of the different treatment groups, and bRFS was compared.ResultsData from a total of 191 patients were included in the analysis (WPRT, n = 108; PBRT, n = 83). The median follow-up period was 66 months. Prior to matching, patients who received WPRT had higher pathologic Gleason scores as well as a higher incidence of pre-SRT PSA levels >0.5 ng/mL and lower rates of concurrent androgen-deprivation therapy. Propensity score matching balanced these characteristics and generated a cohort comprising 56 patients from each group. In the matched cohort, the 5 year bRFS of the WPRT group was significantly higher than that of the PBRT group (65.9 vs. 42.2%, p = 0.017). Multivariate analysis revealed that WPRT was an independent prognostic factor for bRFS (hazard ratio: 0.45, 95% confidence interval: 0.26-0.75, p = 0.002). This benefit of WPRT on bRFS was maintained in subgroup analyses, especially in patients with preoperative PSA level ≤20 ng/mL or pre-SRT PSA level ≥0.4 ng/mL.ConclusionsThese data suggest that, following radical prostatectomy, elective WPRT during SRT may improve bRFS compared with PBRT in selected patients. Patients with preoperative PSA level ≤20 ng/mL or pre-SRT PSA level ≥0.4 ng/mL represent a potential subgroup who benefit most from receiving WPRT. Results of prospective randomized trials are awaited to confirm this finding.
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- 2018
14. Image-guided, whole-pelvic, intensity-modulated radiotherapy for biochemical recurrence following radical prostatectomy in high-risk prostate cancer patients
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Choung-Soo Kim, Hanjong Ahn, Young Seok Kim, and Sang Jun Byun
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0301 basic medicine ,Male ,medicine.medical_treatment ,Cancer Treatment ,lcsh:Medicine ,Toxicology ,Pathology and Laboratory Medicine ,Prostate cancer ,0302 clinical medicine ,Medicine and Health Sciences ,Reproductive System Procedures ,lcsh:Science ,Aged, 80 and over ,Univariate analysis ,Multidisciplinary ,Prostatectomy ,Prostate Cancer ,Prostate Diseases ,Middle Aged ,Radical Prostatectomy ,Oncology ,030220 oncology & carcinogenesis ,Anatomy ,Research Article ,Biochemical recurrence ,Clinical Oncology ,medicine.medical_specialty ,Urology ,Radiation Therapy ,Surgical and Invasive Medical Procedures ,Pelvis ,Lymphatic System ,03 medical and health sciences ,Exocrine Glands ,medicine ,Humans ,Survival analysis ,Aged ,Toxicity ,Surgical Excision ,business.industry ,lcsh:R ,Rectum ,Biology and Life Sciences ,Cancers and Neoplasms ,Prostatic Neoplasms ,medicine.disease ,Radiation therapy ,Gastrointestinal Tract ,Genitourinary Tract Tumors ,030104 developmental biology ,Prostate Bed ,T-stage ,lcsh:Q ,Prostate Gland ,Lymph Nodes ,Radiotherapy, Intensity-Modulated ,Clinical Medicine ,Neoplasm Recurrence, Local ,business ,Digestive System - Abstract
Background The optimal field size of salvage radiotherapy (SRT) for biochemical recurrence, particularly for patients with high-risk prostate cancer, remains undefined. This retrospective analysis was performed to investigate oncological outcomes as well as treatment-related toxicity following salvage intensity-modulated radiotherapy (IMRT) to the whole pelvis and to compare the results with other studies implementing a small field size of the prostate bed. Methods The medical records of 170 patients with high-risk prostate cancer who received SRT for biochemical recurrence following prostatectomy were reviewed. Whole-pelvic IMRT was administered with a median dose of 66 Gy in 30 fractions. To improve treatment accuracy, an endorectal balloon device and daily cone-beam computed tomography were utilized. Androgen-deprivation therapy combined with SRT was administered to 97 (57.1%) patients. Results Eventually, 68 (40.0%) patients showed biochemical progression (BCP) after SRT. With a median follow-up period of 56 months, the 5-year BCP-free survival was 38.6%. The overall and cause-specific survival rates were 90.9% and 96.7%, respectively. Regarding BCP-free survival analysis, pathological T stage, persistent prostate-specific antigen (PSA) elevation after prostatectomy, and preSRT PSA level were significant prognostic factors on univariate analysis. On multivariate analysis, pathological T stage and preSRT PSA value retained their significance. Acute and late grade-3 genitourinary toxicities were observed in one (0.6%) and five (2.9%) patients, respectively. One patient each developed acute and late grade-3 gastrointestinal toxicity. Conclusion SRT to whole pelvis using IMRT and image guidance is as safe as SRT to the prostate bed, but its efficacy should be confirmed in ongoing randomized trials. PreSRT PSA was the only controllable prognostic factor, suggesting the benefit of early SRT.
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- 2018
15. Is Prophylactic Irradiation to Para-aortic Lymph Nodes in Locally Advanced Cervical Cancer Necessary?
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Jinhee Kim, Seung Gyu Park, Ok Bae Kim, Sang Jun Byun, Young Kee Oh, Sanghoon Kwon, and Mi Young Kim
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Cervical cancer ,Survival rate ,Cancer Research ,medicine.medical_specialty ,Uterine cervical neoplasms ,Radiotherapy ,business.industry ,Aortic lymph nodes ,Neoplasm metastasis ,medicine.medical_treatment ,Extended field ,Locally advanced ,medicine.disease ,Surgery ,Radiation therapy ,medicine.anatomical_structure ,Oncology ,Medicine ,Original Article ,Stage (cooking) ,business ,Lymph nodes ,Pelvis - Abstract
Purpose This study evaluated the efficacy of extended field irradiation (EFI) in patients with locally advanced cervical cancer without para-aortic nodal involvement. Materials and Methods A total of 203 patients with locally advanced cervical cancer (International Federation of Gynecology and Obstetrics [FIGO] stage, IB2-IIIB) treated with radiotherapy at Keimyung University Dongsan Medical Center from 1996 to 2010 were retrospectively analyzed. The median patient age was 59 years (range, 29 to 83 years). None of the patients had para-aortic node metastases. Of the 203 patients, 88 underwent EFI and 115 underwent irradiation of the pelvis only. Concurrent chemoradiotherapy (CCRT) was administered to 133 patients. EFI field was used for treatment of 26 patients who received radiotherapy alone and 62 who received CCRT. Results The median follow-up period was 60 months. The 2- and 5-year overall survival (OS) rates were 87.8% and 73.5%, respectively, and the 2- and 5-year disease-free survival rates were 81.7% and 75.0%, respectively, however, no survival differences were observed between the two treatment field groups. EFI tended to increase OS in the radiotherapy alone group, but not in the CCRT group. Conclusion These findings suggest that EFI does not have a significant effect in patients with locally advanced cervical cancer, especially in patients receiving CCRT. Conduct of additional studies will be required in order to confirm these findings.
- Published
- 2014
16. Disease courses in patients with residual tumor following concurrent chemoradiotherapy for locally advanced cervical cancer
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Young Seok Kim, Sang Jun Byun, Joo-Hyun Nam, and Ja Young Kim
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0301 basic medicine ,Adult ,medicine.medical_specialty ,Neoplasm, Residual ,medicine.medical_treatment ,Locally advanced ,Uterine Cervical Neoplasms ,Disease ,Residual ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Stage (cooking) ,Aged ,Neoplasm Staging ,Cervical cancer ,Salvage Therapy ,Chemotherapy ,medicine.diagnostic_test ,business.industry ,Medical record ,Carcinoma ,Obstetrics and Gynecology ,Magnetic resonance imaging ,Chemoradiotherapy ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Tumor Burden ,Survival Rate ,030104 developmental biology ,Oncology ,Neoplasm Regression, Spontaneous ,030220 oncology & carcinogenesis ,Disease Progression ,Female ,business ,Follow-Up Studies - Abstract
Objective To investigate the disease course and identify prognostic factors for survival in patients with residual disease according to post-treatment magnetic resonance imaging (MRI) following definitive concurrent chemoradiotherapy (CCRT) for locally advanced cervical cancer. Methods We reviewed clinical data from the medical records of 545 consecutive women with biopsy-proven, International Federation of Gynecology and Obstetrics stage IB2–IVA uterine cervical cancer treated with CCRT. Post-treatment MRI was checked in all patients 3months after CCRT completion. Out of the 545 patients, 53 with residual cervical cancer based on MRI following definitive CCRT were included in this analysis. Results Thirty-two patients were disease-free at the last follow-up. Of them, 31 had a residual tumor size of ≤2cm. Of these 32 women, 30 showed spontaneous regression of residual tumor during follow-up without salvage treatments, whereas the remaining two were alive with no evidence of disease after salvage surgery and chemotherapy. Disease progression was observed in 21 patients, including 7 local, 8 distant and 6 local and distant failures. Of these 21 women, 13 died of disease, 6 were alive with disease, and 2 remained disease-free after salvage treatments. Initial and residual tumor sizes were significant prognostic factors for overall survival; only residual tumor size was significant for local progression-free survival. Conclusions About 60% of patients with residual disease detected on post-treatment MRI remained disease-free without further disease progression. Careful observation without immediate salvage treatments might be feasible in selected patients with a residual tumor size ≤2cm.
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- 2016
17. Comparison of outcomes between trimodal therapy and radical cystectomy in muscle-invasive bladder cancer: a propensity score matching analysis
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Young Seok Kim, Hanjong Ahn, Beom-Sik Hong, Yeon Joo Kim, Choung-Soo Kim, Sang Jun Byun, Sangjun Yoo, and Jae-Lyun Lee
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medicine.medical_specialty ,medicine.medical_treatment ,030232 urology & nephrology ,chemotherapy ,law.invention ,Cystectomy ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,medicine ,radical cystectomy ,trimodal therapy ,radiotherapy ,Chemotherapy ,Bladder cancer ,business.industry ,Genitourinary system ,Muscle invasive ,medicine.disease ,Surgery ,Radiation therapy ,Oncology ,muscle-invasive bladder cancer ,030220 oncology & carcinogenesis ,Propensity score matching ,Clinical Research Paper ,business ,human activities - Abstract
// Yeon Joo Kim 1 , Sang Jun Byun 1 , Hanjong Ahn 2 , Choung-Soo Kim 2 , Beom-Sik Hong 2 , Sangjun Yoo 2 , Jae-Lyun Lee 3 and Young Seok Kim 1 1 Department of Radiation Oncology, Asan Medical Center, University of Ulsan, College of Medicine, Songpa-Gu, Seoul, Republic of Korea 2 Urology, Asan Medical Center, University of Ulsan, College of Medicine, Songpa-Gu, Seoul, Republic of Korea 3 Oncology, Asan Medical Center, University of Ulsan, College of Medicine, Songpa-Gu, Seoul, Republic of Korea Correspondence to: Young Seok Kim, email: // Keywords : muscle-invasive bladder cancer, radical cystectomy, trimodal therapy, radiotherapy, chemotherapy Received : July 14, 2016 Accepted : March 15, 2017 Published : March 25, 2017 Abstract Although radical cystectomy (RC) is considered as the standard therapy for muscle-invasive bladder cancer (MIBC), trimodal therapy (TMT) combining transurethral resection of the tumor with radiotherapy and chemotherapy is increasingly recommended as an alternative approach for bladder preservation. In the absence of randomized trials, we compared the clinical outcomes between RC and TMT using propensity score matching with 50 patients in the RC arm and 29 patients in the TMT arm. With respective median follow-up periods of 23 and 32 months for the RC and TMT groups, 5-year distant metastasis-free survival (58% vs. 67%), overall survival (56% vs. 57%), and cancer-specific survival (69% vs . 63%) rates between the RC and TMT groups, respectively, were similar. However, the 5-year local recurrence-free survival was significantly better in the RC group than in the TMT group (74% vs . 35%). Following TMT, acute grade 3 hematological ( n = 2) and late grade 3 genitourinary ( n = 1) toxicities were reported. These findings demonstrated that oncological outcomes of TMT were comparable with those of RC, except for poorer local control. Large-scale, randomized trials are warranted to confirm the findings of the present retrospective comparison and to guide toward best treatment options.
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- 2016
18. Interval between Surgery and Radiation Therapy Is an Important Prognostic Factor in Treatment of Rectal Cancer
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Sang Jun Byun, Seong Kyu Baek, Young Kee Oh, Jinhee Kim, and Seung Gyu Park
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Cancer Research ,Chemotherapy ,medicine.medical_specialty ,Colorectal cancer ,business.industry ,medicine.medical_treatment ,Hazard ratio ,Rectal neoplasms ,Retrospective cohort study ,Prognosis ,medicine.disease ,Confidence interval ,Surgery ,Metastasis ,Radiation therapy ,Pharmacotherapy ,Oncology ,medicine ,Original Article ,Adjuvant radiotherapy ,Drug therapy ,business - Abstract
Purpose The purpose of this study is to evaluate survival and prognostic factors for rectal cancer, including interval between surgery and radiation therapy after surgery, radiation therapy, and chemotherapy. Materials and Methods We conducted a retrospective study of 153 patients with rectal cancer who were treated with surgery, radiotherapy with/without chemotherapy at Keimyung University Dongsan Medical Center from January, 1988 to December, 2005. The study included 89 males and 64 females, with a median age of 56 years (range, 23 to 81 years). Tumor, node and metastasis (TNM) was I in 23 patients, II in 39, and III in 91. Radiation therapy was performed on pelvic fields using a median dose of 54 Gy five days per week, 1.8 Gy once per day. Ninety two patients were treated with radiotherapy, 43 with concurrent chemo-radiation therapy and 18 with sequential therapy after surgery. The median follow-up period was 52 months (range, 4 to 272 months). The interval between surgery and radiation was 1-25 weeks (median, 5 weeks). Results Two-year and five-year overall survival rate was 64.7% and 46.4%, respectively. Two-year and five-year disease-free-survival (DFS) rate was 58.6% and 43.1%, respectively. Median DFS was 39 months. Loco-regional failure was evident in 10.5% of patients, 8.4% had distant metastasis, and 9.2% had both. In multivariate analysis, TNM stage and interval between surgery and radiation therapy (≤5 weeks vs. >5 weeks; 95% confidence interval, 1.276 to 2.877; hazard ratio, 1.916; p=0.002) were significant prognostic factors of DFS. Conclusion Survival rates for rectal cancer after surgery, chemotherapy, and radiation therapy were similar to those reported in previous studies. Starting radiation therapy as soon as possible after surgery, especially within the first five weeks after surgery, is suggested.
- Published
- 2012
19. Concurrent chemoradiotherapy improves survival outcome in muscle-invasive bladder cancer
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Byung Hoon Kim, Sang Jun Byun, Jinhee Kim, and Young Kee Oh
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Oncology ,medicine.medical_specialty ,Prognostic factor ,Survival rate ,Multivariate analysis ,medicine.medical_treatment ,Urology ,Internal medicine ,medicine ,Urinary bladder neoplasm ,Radiology, Nuclear Medicine and imaging ,Clinical Investigation ,Chemotherapy ,Bladder cancer ,Radiotherapy ,business.industry ,Cancer ,medicine.disease ,Concurrent chemoradiotherapy ,Radiation therapy ,Bladder preservation ,Original Article ,business - Abstract
Purpose To evaluate survival rates and prognostic factors related to treatment outcomes after bladder preserving therapy including transurethral resection of bladder tumor, radiotherapy (RT) with or without concurrent chemotherapy in bladder cancer with a curative intent. Materials and methods We retrospectively studied 50 bladder cancer patients treated with bladder-preserving therapy at Keimyung University Dongsan Medical Center from January 1999 to December 2010. Age ranged from 46 to 89 years (median, 71.5 years). Bladder cancer was the American Joint Committee on Cancer (AJCC) stage II, III, and IV in 9, 27, and 14 patients, respectively. Thirty patients were treated with concurrent chemoradiotherapy (CCRT) and 20 patients with RT alone. Nine patients received chemotherapy prior to CCRT or RT alone. Radiation was delivered with a four-field box technique (median, 63 Gy; range, 48.6 to 70.2 Gy). The follow-up periods ranged from 2 to 169 months (median, 34 months). Results Thirty patients (60%) showed complete response and 13 (26%) a partial response. All patients could have their own bladder preserved. Five-year overall survival (OS) rate was 37.2%, and the 5-year disease-free survival (DFS) rate was 30.2%. In multivariate analysis, tumor grade and CCRT were statistically significant in OS. Conclusion Tumor grade was a significant prognostic factor related to OS. CCRT is also considered to improve survival outcomes. Further multi-institutional studies are needed to elucidate the impact of RT in bladder cancer.
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- 2015
20. A Comparison of Outcomes Between Concurrent Chemoradiation Therapy and Radiation Therapy Alone in Cancer of the Uterine Cervix: A Single Institutional Experience
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Sang Jun Byun, Chi-Heum Cho, Ok Bae Kim, Jin Young Kim, Seung Gyu Park, Young Kee Oh, and Euncheol Choi
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Radiation ,business.industry ,medicine.medical_treatment ,Cancer ,Concurrent chemoradiation ,medicine.disease ,Radiation therapy ,Uterine cervix ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,business - Published
- 2012
21. Postoperative radiotherapy for endometrial cancer
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Ok Bae Kim, Seung Gyu Park, Sang Hoon Kwon, Sang Jun Byun, Eun Cheol Choi, and Jinhee Kim
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medicine.medical_specialty ,medicine.medical_treatment ,medicine ,Carcinoma ,Radiology, Nuclear Medicine and imaging ,Clinical Investigation ,Stage (cooking) ,Lymph node ,Gynecology ,Univariate analysis ,Endometrial neoplasm ,Hysterectomy ,business.industry ,Endometrial cancer ,Prognosis ,medicine.disease ,Postoperative procedures ,medicine.anatomical_structure ,Oncology ,Original Article ,Lymphadenectomy ,Adjuvant radiotherapy ,Radiology ,Menopause ,business ,Endometrial Neoplasm - Abstract
Purpose To investigate the prognostic factors and effectiveness of postoperative radiotherapy alone for endometrial carcinoma. Materials and Methods Sixty four patients with stage I-III endometrial cancer (EC) treated with postoperative radiotherapy alone between January 1989 and December 2008 at the Keimyung University Dongsan Medical Center were chosen for the present study. Typically, total hysterectomy, salpingo-oophorectomy and lymphadenectomy were performed on the patient's pelvis. Total dose from 50.4 Gy to 63 Gy was irradiated at pelvis or extended field. Thirteen patients were treated with Co-60 or Ir-192 intracavitary radiotherapy. Follow-up periods were from 7 to 270 months, with a median of 56 months. Results Five year overall survival (OS) rate was 58.7%, respectively. Five year disease-free survival (DFS) rate was 59.2%, respectively. In univariate analysis for OS and DFS, stage, menopausal age, type of operation, serosal invasion, and lymph node involvement were found to be statistically significant. Histologic type was marginally significant. In multivariate analysis for OS and DFS, stage, types of operation, histologic type were also found to be statistically significant. Treatment failure occurred in 14 patients. The main pattern of failure was found to be distant metastasis. Time to distant metastasis was from 3 to 86 months (median, 12 months). There were no grade 3 or 4 complications. Conclusion Stage, types of operation, and histologic type could be the predictive prognostic factors in patients. We contemplated postoperative radiation as effective and safe treatment method for EC. Additional treatment would be needed to reduce distant metastasis.
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- 2012
22. Radiation Therapy for Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis
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Ok Bae Kim, Jae Seok Hwang, Sang Jun Byun, Tae Jin Choi, Jinhee Kim, Young Kee Oh, and Seung Gyu Park
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Oncology ,Radiation therapy ,medicine.medical_specialty ,business.industry ,Hepatocellular carcinoma ,Internal medicine ,medicine.medical_treatment ,medicine ,Portal vein ,medicine.disease ,business ,Gastroenterology ,Thrombosis - Abstract
목 적: 간문맥종양혈전증을 동반한 간세포암에서 방사선 치료의 효과와 이에 영향을 미치는 인자들에 대해 알아보기 위하여 연구를 계획하였다 대상 및 방법: 2004년 12월부터 2009년 4월까지 계명대학교 동산의료원 방사선종양학과에서 간세포종양에 의한 간문맥 혈전부위에 방사선 치료를 받은 환자는 70명이었고 그 중 30 Gy 미만의 방사선 조사를 받은 19명의 환자와 간이식을 시행한 1명의 환자를 제외한 50명의 환자를 대상으로 하였다. 성별 구성은 남성이 45명, 여성이 5명이었고, 연령분포는 32세에서 79세(중앙값, 55세)이었다. 39명의 환자가 방사선 치료 전 간동맥 화학 색전술, 경피적 에탄올 주입술 등의 시술을 받았다. TNM 병기에 따른 분류는 III기 27명(54.0%), IV기 23명(46.0%)이었다. 방사선 치료는 총 조사선량 30~54 Gy(중앙값, 45)의 외부방사선을 조사하였으며, 이 중 동시항암화학방사선 치료를 받은 환자는 30명 (60.0%)이었다. 추적관찰기간은 3개월에서 70개월(중앙값, 13.5)이었다. 곁 과: 방사선치료 시작부터 전체 환자의 중앙생존기간은 9개월이었고, 1년 생존률은 24.9%, 2년 생존률은 11.2%이었다. 현재 무병생존은 3명(6.0%), 유병생존은 7명(14.0%), 질병악화로 인한 사망은 40명(80.0%)이었다. 생존율에 영향을 미치는 인자에 대한 단변량분석 상, 동시항암화학방사선 치료는 방사선치료 단독치료보다 낮은 생존율을 보였다(p=0.034). 방사선치료에 대한 종양의 반응(p=0.037), CLIP 병기(p=0.017), TNM 병기(p=0.041)가 통계적으로 유의한 결과를 보였다. 방사선에 의한 간독성은 관찰되지 않았다. 결론: 간문맥종양혈전을 동반한 간세포암에서 방사선치료는 안전하게 생존율의 향상을 얻을 수 있는 방법으로 생각된다. 향후 간문맥종양혈전을 동반한 간세포암에서 방사선치료의 역할을 알아보기 위한 무작위 전향적 임상연구가 필요하리라 생각된다. 【Purpose: To evaluate the effectiveness of radiation therapy (RT) for hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) and to analyze the prognostic factors. Materials and Methods: From December 2004 to April 2009, 70 patients who had HCC with PVTT were treated with RT at Keimyung University Dongsan Medical Center. Nineteen patients whose total dose was below 30 Gy and one patient who underwent liver transplantation were excluded. The remaining 50 patients (45 males, 5 females; median age 55 years) were analyzed. According to the LCSGJ TNM stage, there were 27 patients (54.0%) with stage III and 23 (46.0%) with stage IV. Total dose of 30~54 Gy was administered (median 45). Thirty patients (60.0%) were treated with concurrent chemoradiation therapy (CCRT). The median follow-up duration was from 13.5 months (range, 3 to 70 months). Results: The median survival time from the start of RT was 9 months. One-year and 2-year overall survival rates were 24.9% and 11.2%, respectively. At the follow-up time, three patients (6.0%) displayed no evidence of disease. Seven patients (14.0%) were alive with disease, and 40 (80.0%) patients had expired due to disease progression. CCRT was associated with worse survival than RT alone (p=0.034), Response to RT (p=0.037), CLIP stage (p=0.017), and TNM stage (p=0.041) were statistically significant prognostic factors. There was no radiation-induced liver disease. Conclusion: RT is an effective and safe modality for HCC with PVTT. Further studies such as prospective randomized trials are needed to confirm the role of RT for HCC with PVTT.】
- Published
- 2011
23. Concurrent Chemoradiotherapy in Locally Advanced Esophageal Cancer
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Sang Jun Byun, Ok Bae Kim, Jinhee Kim, and Hong Suk Song
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medicine.medical_specialty ,Chemotherapy ,Univariate analysis ,business.industry ,medicine.medical_treatment ,Esophageal cancer ,medicine.disease ,Gastroenterology ,Surgery ,Statistical significance ,Internal medicine ,Medicine ,Stage (cooking) ,business ,Prospective cohort study ,Survival rate ,Chemoradiotherapy - Abstract
†Purpose: This study was designed to evaluate the results of local control, survival rate, prognostic factors, and failure pattern in locally advanced esophageal cancer. Materials and Methods: We retrospectively studied 50 patients with locally advanced esophageal cancer treated with concurrent chemoradiotherapy at Keimyung University Dongsan Medical Center from June of 1999 to August of 2008. Seven patients with inappropriate data were excluded, and 43 patients were analyzed. There were 39 males and four female patients ranging in age from 43 to 78 years (median, 63 years). There were seven patients with stage IIA and 36 with stage III. Irradiation from 46 Gy to 63 Gy (median, 54 Gy) was carried out 5 days per week, 1.8 Gy once a day. There were eight patients with neo-adjuvant chemotherapy, and we mostly used 5-fluorouracil, cisplatin with 3 cycles for concurrent che motherapy. The range of follow up periods was from 2 to 82 months (median, 15.5). Results: There were nine patients that exhibited a complete response, 23 that exhibited a partial response, 9 that exhibited no response, and 2 that exhibited disease progression. The median survival time was 15 months. Two-year and 5-year survival rates were 36.5% and 17.3%, respectively. Two-year and 5-year disease-free survival rates were 32.4% and 16%, respectively. Treatment failure occurred in 22 patients (51.2%). Patterns of failure were categorized as local failure in 18 patients and distant metastasis in four patients. In a univariate analysis for prognostic factors related to overall survival and disease-free survival, the hemoglobin levels during chemoradiotherapy (≥ 12 vs.
- Published
- 2011
24. Long Term Results of Radiation Therapy in Early Glottic Cancer
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Jinhee Kim and Sang Jun Byun
- Subjects
Radiation therapy ,medicine.medical_specialty ,business.industry ,Glottic cancer ,medicine.medical_treatment ,Medicine ,Tumor cells ,Radiology ,Long term results ,business - Published
- 2009
25. Long-term Results of Breast-conserving Surgery and Radiation Therapy in Early Breast Cancer
- Author
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Sang Jun Byun and Jinhee Kim
- Subjects
Chemotherapy ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Cosmesis ,medicine.disease ,Surgery ,Radiation therapy ,Breast cancer ,medicine ,Breast-conserving surgery ,Hormonal therapy ,Stage (cooking) ,business ,Tamoxifen ,medicine.drug - Abstract
Purpose: To evaluate the long-term results after breast-conserving surgery and radiation therapy in early breast cancer in terms of failure, survival, and cosmesis. Materials and Methods : One hundred fifty-four patients with stage I and II breast cancer were treated with conservative surgery plus radiotherapy between January 1992 and December 2002 at the Keimyung University Dongsan Medical Center. According to TNM stage, 93 patients were stage I, 50 were IIa, and 11 were IIb. The affected breasts were irradiated with 6 MV photons to 50.4 Gy i n 28 fractions over 5.5 weeks with a boost irradiation dose of 10∼16 Gy to the excision site. Chemotherapy was administered in 75 patients and hormonal therapy in 92 patients with tamoxifen. Follow-up periods were 13∼179 months, with a median of 92.5 months. Results : The 5- and 10-year overall survival rates were 97.3% and 94.5%, respectively. The 5- and 10-year disease-free survival (5YDFS and 10YDFS, respectively) rates were 92.5% and 88.9%, respectively; the ultimate 5YDFS and 10YDFS rates after salvage treatment were 93.9% and 90.2%, respectively. Based on multivariate analysis, only the interval between surgery and radiation therapy (≤6 weeks vs. >6 weeks, p=0.017) was a statistically significant prognostic factor for DFS. The major type of treatment failure was distant failure (78.5%) and the most common distant metastatic site was the lungs. The cosmetic results were good-to-excellent in 96 patients (80.7%). Conclusion : Conservative surgery and radiation for early stage invasive breast cancer yielded excellent survival and cosmetic results. Radiation therapy should be started as soon as possible after breast-conserving surgery in patients with early breast cancer, ideally within 6 weeks.
- Published
- 2009
26. A Case Report of Intraocular Metastasis Treated with Radiotherapy
- Author
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Sang Jun Byun, Kwang Soo Kim, Ok Bae Kim, Jinhee Kim, and Ho Jun Lee
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Radiation therapy ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,medicine ,Radiology ,medicine.disease ,business ,Metastasis - Published
- 2009
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