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4 results on '"Sabine Zaepfel"'

1. Low glycosylated ferritin is a sensitive biomarker of severe COVID-19

Author

Pascal Sève, Maxime Fauter, Sébastien Viel, Yvan Jamilloux, Pierre Pradat, Marine Villard, Lorna Garnier, Sabine Zaepfel, Thomas Henry, Thierry Walzer, and Julie Fiscus

Subjects
Adult, Male, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Immunology, Betacoronavirus, Prognostic markers, Internal medicine, Correspondence, medicine, Humans, Immunology and Allergy, Prospective Studies, Pandemics, Aged, Aged, 80 and over, biology, business.industry, SARS-CoV-2, Disease progression, COVID-19, Diagnostic markers, Middle Aged, Ferritin, Hospitalization, Endocrinology, Infectious Diseases, Ferritins, biology.protein, Disease Progression, Biomarker (medicine), Female, business, Coronavirus Infections, Biomarkers
Published
2020
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2. Establishment of indicators to improve clinical analysis prescribing patterns

Author

Matthieu Pecquet, Sabine Zaepfel, Mathieu Fontaine, and Danièle Agi

Subjects
Gynecology, medicine.medical_specialty, Clinical Laboratory Techniques, business.industry, Health Care Costs, General Medicine, Clinical Laboratory Services, Quality Improvement, Prescriptions, Professional Role, Medical Laboratory Personnel, Health Resources, Humans, Medicine, Practice Patterns, Physicians', business, Quality Indicators, Health Care
Abstract

La juste prescription de biologie medicale fait partie du role de prestation de conseil du biologiste. Elle permet d’optimiser la prise en charge du patient et de maitriser les depenses. Avec l’aide de quatre indicateurs, nous cherchons a evaluer et suivre la qualite de la prescription des examens de biologie medicale (EBM). La confrontation des dossiers cliniques et des analyses prescrites a l’entree aux urgences en juin 2013 montre que 73 % de prescriptions de TnT sont justifiees contre moins de 50 % pour le NTproBNP (27 %), le TCA (37 %), le TP (33 %) et l’INR (23 %). Parallelement a diverses actions menees comme la formation des equipes, le renforcement du dialogue clinicien-biologiste et l’optimisation de l’outil informatique, nous avons constate une evolution des pratiques. De 2013 a 2015, on observe une diminution significative des associations inadequates TP/TCA mensuelles provenant du service des grands brules, du nombre d’analyses prescrites pour 100 entrees aux urgences, ainsi que de la depense mensuelle de biologie du service des urgences exprimee en nombre de B/entree (de 136 a 107). L’utilisation d’indicateurs est necessaire pour evaluer et suivre la qualite de la prescription des EBM. Il nous parait pertinent d’associer l’utilisation d’un indicateur global (B/sejour ou Nb d’EBM/mois) au suivi des associations inadequates. La strategie choisie devra etre adaptee a chaque type de prescripteur.

Published
2017
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3. Reference percentiles for paired arterial and venous umbilical cord blood gases: An indirect nonparametric approach

Author

Laurent Desmurs, Sabine Zaepfel, Régine Cartier, Muriel Doret-Dion, Denis Monneret, Laurence Chardon, Maison des Sciences de l'Homme et de la Société Sud-Est (MSHS Sud-Est), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Pascal Paoli (UPP)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon

Subjects
Male, 030213 general clinical medicine, medicine.medical_specialty, Percentile, Umbilical Veins, [SDV]Life Sciences [q-bio], Clinical Biochemistry, 030204 cardiovascular system & hematology, Umbilical cord, pCO2, Umbilical Arteries, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Oxygen saturation (medicine), Skewed data, business.industry, Nonparametric statistics, General Medicine, Carbon Dioxide, Hydrogen-Ion Concentration, Fetal Blood, Oxygen, % total haemoglobin, medicine.anatomical_structure, Concomitant, Cardiology, Female, business
Abstract

BACKGROUND Reference intervals for arterial and venous umbilical cord blood gas (UCBG) parameters are scarce, are mainly focused on pH, pO2, pCO2 and base deficit, and are usually assessed using parametric tests, despite a generally skewed data distribution. Here, the purpose is to determine reference percentiles for nine parameters of concomitant arterial and venous UCBG (CAV-UCBG) from neonates at birth, using nonparametric tests. METHODS Results of CAV-UCBG, assayed over a 4.5-year period, were extracted from a hospital laboratory database for pH, pCO2, pO2, oxygen saturation, concentration of total oxygen, total carbon dioxide, hydrogen carbonate, total haemoglobin, and acid-base excess. Exclusion criteria were: a venous-arterial pH difference

Published
2019
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4. Atteintes myocardiques au cours de la maladie à coronavirus 19 (Covid-19) : principaux mécanismes physiopathologiques et utilité clinique des biomarqueurs cardiaques

Author

Kamel, Saïd, Raynor, Alexandre, Zozor, Samuel, Lacape, Geneviève, Brunel, Valéry, Nivet-Antoine, Valérie, Collin-Chavagnac, Delphine, Peoc’h, Katell, Cohen, Ariel, Lassoued, Amin Ben, Chévrier, Marc, Alemann, Mathieu, Lessinger, Jean-Marc, Bérard, Annie, Sapin, Vincent, Beauvieux, Marie-Christine, Levy, Pacifique, Lehmann, Sylvain, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Bordeaux [Bordeaux], Université de Bordeaux (UB), Laboratoire de biochimie générale [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Innovations thérapeutiques en hémostase (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), CHU Necker - Enfants Malades [AP-HP], Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Saint-Antoine [AP-HP], Thrombose, atherothrombose et pharmacologie appliquée, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Tenon [AP-HP], Hôpital de la Timone [CHU - APHM] (TIMONE), Hospices Civils de Lyon (HCL), Nouvel Hôpital Civil de Strasbourg, Les Hôpitaux Universitaires de Strasbourg (HUS), Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Centre de résonance magnétique des systèmes biologiques (CRMSB), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Pour le Groupe de Travail de la SFBC « Marqueurs Biochimiques de la pathologie Covid-19 »: Isabelle Aimone-Gastin, Stéphanie Alcaraz, Stéphane Allouche, Malika Balduyck, Françoise Barbé, Yann Barguil, Jean-Philippe Bastard, Jean-Louis Beaudeux, Marie-Christine Beauvieux, Amin Ben Lassoued, Isabelle Benz de Bretagne, Annie Bérard, Laurent Bermont, Edith Bigot-Corbel, Muriel Bost, Valery Bourbonneux, Valery Brunel, Jean-Luc Carré, Camille Chenevier-Gobeaux, Marc Chevrier, Giulia Chinetti, Delphine Collin-Chavagnac, Hervé Delacour, Delphine Delevallée, François Desroys du Roure, Patrice Faure, Jean-Philippe Galhaud, Anne Galinier, Thierry Hauet, Carine Helj, Emilie Jolly, Said Kamel, Sylvain Lehmann, Aline Leroy, Jean-Marc Lessenger, Pacifique Levy, Anne-Marie Lorec-Penet, Samir Mesli, Dagui Monnet, Caroline Moreau, Laurence Mouly, Valérie Nivet-Antoine, Nathalie Oueidat, Mathieu Pecquet, Katell Peoc’h, Laurence Piéroni, Carole Poupon, Martine Roubille, Benoit Rucheton, Medhi Sakka, Vincent Sapin, Vincent Saunier, Florian Scherrer, François Schmitt, Sabine Zaepfel, Samuel Zozor, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Clermont-Ferrand, Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), VIAUD, Karine, Normandie Université (NU)-Centre hospitalier universitaire de Rouen, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)

Subjects
Adult, Male, medicine.medical_specialty, Myocarditis, [SDV]Life Sciences [q-bio], Myocardial Infarction, troponine, Disease, Systemic inflammation, Predictive Value of Tests, Internal medicine, myocarde, Coagulopathy, medicine, myocardium, Humans, Hospital Mortality, Myocardial infarction, Pandemics, Aged, Aged, 80 and over, Endocarditis, biology, business.industry, SARS-CoV-2, troponin, Heart, General Medicine, Middle Aged, Prognosis, medicine.disease, Troponin, Pathophysiology, 3. Good health, myocardite, [SDV] Life Sciences [q-bio], peptides natriurétiques, biology.protein, Cardiology, Female, France, Myocardial infarction diagnosis, medicine.symptom, myocarditis, business, Covid-19, natriuretic peptides, Biomarkers
Abstract

International audience; Covid-19 is responsible for myocardial injury in many infected patients, which is associated with severe disease and critical illness. The mechanisms by which SARS-CoV-2 may cause myocardial damage involve direct effect of the virus in cardiac cells and indirect effect due to the clinical consequences of Covid-19. Cardiomyocytes are well known to express Angiotensin-Converting Enzyme-2 receptors (ACE-2) to facilitate the virus cell entry, which could explain the occurrence of myocarditis, functional alterations in the myocardium, and more rarely, myocardial infarction. Myocardial injury may also be secondary to systemic inflammation or coagulopathy due to complicated Covid-19. The existence of a cardio-intestinal axis with alteration of tryptophan metabolism in the small bowel leading first to colitis and then to systemic inflammation has also been evoked to explain the myocardial injury. Morphological and metabolic disturbances of the heart during the Covid-19 are associated with elevated concentrations of cardiac blood biomarkers, mainly troponins and natriuretic peptides. The determination of these biomarkers has proven to be very useful for diagnosis, prognosis, and risk stratification. Indeed, recent data demonstrated that about 20% of infected patients admitted to the hospital have elevated troponin or BNP levels, and Covid-19 patients with elevated troponin concentrations beyond the diagnostic threshold (99th percentile) were associated with a higher risk of in-hospital mortality. In conclusion, after more than a year of a unique global pandemic, it is now clearly established that myocardial injury during Covid-19 is frequent and strongly contributes to the severity of the disease. Cardiac alterations secondary to direct infection of cardiac cells by SARS-CoV-2 or to the clinical consequences of Covid-19 are associated with elevated levels of cardiac biomarkers in blood, whose measurement is crucial in clinical decision making.

Published
2021
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