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2. Therapeutic Effects of Hesperetin and Nano Hesperetin on Ketamine-Induced Hepatotoxicity

Author

S. Khanjani Jelodar, A Hajizadeh Moghadam, M Parhizkar, and R Sirafi

Subjects
Drug, Phytochemistry, ketamine, media_common.quotation_subject, RM1-950, Pharmacognosy, chemistry.chemical_compound, antioxidant enzymes, RA1190-1270, medicine, Ketamine, Medicinal plants, media_common, Pharmacology, Traditional medicine, business.industry, hesperetin, Therapeutic effect, Hesperetin, nano hesperetin, Complementary and alternative medicine, chemistry, liver damage, Toxicology. Poisons, Pharmaceutics, Therapeutics. Pharmacology, business, medicine.drug
Abstract

Background: Ketamine (KET) causes oxidative stress and liver damage. Hesperetin plays an important role in the prevention of inflammatory processes and associated with oxidative stress. Objective: The purpose of this study was to analyze the protective role of hesperetin and its nanocrystal on hepatotoxicity induced by ketamine in mice. Methods: In this research, 30 male mice were divided into six groups: control, poisoned (KET 10 mg/kg/10 day injected intraparitary), hesperetin and hesperetin nanoparticles treated poisoning groups (10 and 20 mg/kg for four weeks orally after KET administration). Finally, the malondialdehyde (MDA) and glutathione (GSH) levels, Catalase (CAT), Superoxide dismutase (SOD), Glutathione peroxidase (GPX) and Glutathione reductase (GRX) activity in liver tissue as well as the its histological changes were investigated. Results: The level of GSH and antioxidant enzyme activity in the liver were significantly (P

Published
2019

3. Cervical preparation prior to outpatient hysteroscopy: friend or foe?

Author

S Khanjani, X Foo, and S Latif

Subjects
Pregnancy, medicine.medical_specialty, medicine.diagnostic_test, business.industry, General surgery, MEDLINE, Obstetrics and Gynecology, Hysteroscopy, medicine.disease, Oxytocics, Outpatients, medicine, Humans, Female, business, Labor Stage, First, Misoprostol, Outpatient hysteroscopy, medicine.drug
Published
2020

4. POSTER VIEWING SESSION - ENDOMETRIOSIS, ENDOMETRIUM, IMPLANTATION AND FALLOPIAN TUBE

Author

K. K. Palial, J. Drury, L. Heathcote, A. Valentijin, R. G. Farquharson, R. Gazvani, P. S. Rudland, D. K. Hapangama, N. Celik, O. Celik, E. Aktan, E. Ozerol, E. Celik, K. Bozkurt, H. Paran, S. Hascalik, I. Ozerol, T. Arase, T. Maruyama, H. Uchida, K. Miyazaki, H. Oda, S. Uchida-Nishikawa, M. Kagami, A. Yamazaki, K. Tamaki, Y. Yoshimura, M. De Vos, C. Ortega, J. Smitz, I. Van Vaerenbergh, C. Bourgain, P. Devroey, D. Luciano, C. Exacoustos, E. Zupi, A. A. Luciano, D. Arduini, W. A. Palomino, F. Argandona, P. Kohen, R. Azua, A. Scarella, L. Devoto, B. McKinnon, N. A. Bersinger, M. D. Mueller, M. Bonavita, M. Mattila, F. P. Ferreira, V. Maia-Filho, A. M. Rocha, P. Serafini, E. L. A. Motta, H. Kim, C. H. Kim, R. M. You, H. Y. Nah, J. W. Lee, H. J. Kang, B. M. Kang, H. Letur - Koenirsch, D. Haouzi, F. Olivennes, C. Rouleau, P. Cohen-Bacri, H. Dechaud, S. Hamamah, T. D'Hooghe, L. Hummelshoj, G. A. J. Dunselman, C. D. Dirksen, W. E. R. F. EndoCost Consortium, S. Simoens, R. Novembri, S. Luisi, P. Carrarelli, A. L. L. Rocha, P. Toti, F. M. Reis, P. Florio, F. Petraglia, K. D. Bruce, K. H. Sadek, N. Macklon, F. R. Cagampang, Y. Cheong, M. Goudakou, A. Kalogeraki, I. Matalliotakis, A. Papatheodorou, T. Pasadaki, A. Karkanaki, I. Prapas, I. Panagiotidis, E. Kasapi, D. Barlow, J. Oliver, E. Loumaye, M. Khanmohammadi, S. kazemnejad, S. darzi, S. Khanjani, A. Zarnani, M. Akhondi, C. W. Tan, C. P. Ng, S. F. Loh, H. H. Tan, M. Choolani, L. Griffith, J. Chan, K. L. Andersson, J. Sundqvist, G. Scarselli, K. Gemzell-Danielsson, P. G. Lalitkumar, S. Jana, R. Chattopadhyay, C. Datta Ray, K. Chaudhury, B. N. Chakravarty, N. Hannan, J. Evans, C. Hincks, L. J. F. Rombauts, L. A. Salamonsen, D. Choi, J. Lee, J. Park, H. Chang, M. Kim, K. Hwang, K. Takeuchi, T. Kurematsu, Y. Fukumoto, Y. Yuki, Y. Kuroki, Y. Homan, Y. Sata, M. Takeuchi, E. Munoz Munoz, G. Ortiz Olivera, I. Fernandez Lopez, B. Martinez Martinez, J. Aguilar Prieto, S. Portela Perez, A. Pellicer Martinez, M. Keltz, M. Sauerbrun, A. Breborowicz, E. Gonzales, S. Vicente-Munoz, L. Puchades-Carrasco, I. Morcillo, J. J. Hidalgo, J. Gilabert-Estelles, E. Novella-Maestre, A. Pellicer, A. Pineda-Lucena, K. A. Yavorovskaya, T. A. Okhtyrskaya, T. A. Demura, N. M. Faizulina, L. S. Ezhova, E. A. Kogan, J. P. Bilibio, C. A. B. Souza, G. P. Rodini, V. Genro, C. G. Andreoli, E. de Conto, J. S. L. Cunha-Filho, M. Saare, D. Soritsa, L. Jarva, K. Vaidla, P. Palta, M. Laan, H. Karro, A. Soritsa, A. Salumets, M. Peters, A. Miskova, M. Pilmane, D. Rezeberga, S. Assou, H. Letur, P. Piomboni, A. Stendardi, L. Gambera, V. De Leo, R. Focarelli, K. Tamm, J. Simm, M. Metsis, A. Vodolazkaia, A. Fassbender, C. M. Kyama, A. Bokor, D. Schols, D. Huskens, C. Meuleman, K. Peeraer, C. Tomassetti, T. M. D'Hooghe, K. Machens, W. Afhuppe, A. Schulz, K. Diefenbach, B. Schutt, T. Faustmann, J. Reischl, S. Altmae, J. Reimand, T. Laisk, O. Hovatta, R. Kolde, J. Vilo, A. Stavreus-Evers, J. H. Lee, S. G. Kim, Y. Y. Kim, I. H. Park, H. G. Sun, K. H. Lee, K. Ezoe, H. Kawano, A. Yabuuchi, K. Ochiai, H. Nagashima, H. Osada, N. Kagawa, O. Kato, I. Tamura, H. Asada, T. Taketani, H. Tamura, N. Sugino, J. Garcia Velasco, L. Prieto, J. F. Quesada, O. Cambero, M. Toribio, C. Y. Hur, K. S. Lim, W. D. Lee, J. H. Lim, A. Germeyer, L. Nelson, A. Graham, J. Jauckus, T. Strowitzki, B. Lessey, I. Gyulmamedova, O. Illina, I. Illin, I. Mogilevkina, A. Chaika, O. Nosenko, I. Boykova, E. Gulmamedova, H. Isik, O. Moraloglu, A. L. I. Seven, S. Kilic, U. Erkayiran, M. Caydere, S. Batioglu, M. Alhalabi, S. Samawi, A. Taha, N. Kafri, S. Modi, A. Khatib, J. Sharif, A. Othman, S. Lancuba, C. Branzini, M. Lopez, A. Baricalla, C. Cristina, J. Chen, Y. Jiang, X. Zhen, Y. Hu, G. Yan, H. Sun, J. Mizumoto, J. Ueno, F. M. Carvalho, G. Casals, J. Ordi, M. Guimera, M. Creus, F. Fabregues, R. Casamitjana, F. Carmona, J. Balasch, Y. S. Choi, K. C. Kim, K. H. Kim, B. S. Lee, S. H. Kim, L. Overbergh, E. Verdrengh, C. Kyama, E. Waelkens, C. Mathieu, T. Iwasa, K. Hatano, E. Hasegawa, H. Ito, K. Isaka, F. Reis, K. S. Lee, J. K. Joo, J. B. Son, J. R. Choi, A. Vidali, D. H. Barad, N. Gleicher, M. Sayyah-Melli, and M. Kazemi-Shishvan

Subjects
Gynecology, medicine.medical_specialty, business.industry, Obstetrics, Rehabilitation, Endometriosis, Obstetrics and Gynecology, Endometrium, medicine.disease, medicine.anatomical_structure, Reproductive Medicine, medicine, Session (computer science), business, Fallopian tube
Published
2011

5. Prostaglandin F2-alpha receptor regulation in human uterine myocytes

Author

Z. Liang, S.R. Sooranna, N. Engineer, M. Tattersall, S. Khanjani, P.R. Bennett, L. Myatt, and M.R. Johnson

Subjects
Adult, Medroxyprogesterone, Embryology, Prostaglandin F receptor, medicine.medical_specialty, Proto-Oncogene Proteins c-jun, medicine.medical_treatment, Blotting, Western, Interleukin-1beta, Receptors, Prostaglandin, Biology, chemistry.chemical_compound, Pregnancy, Internal medicine, Cyclic AMP, Genetics, medicine, Humans, Protein kinase A, Receptor, Molecular Biology, Cells, Cultured, Progesterone, Protein kinase C, Muscle Cells, Sulfonamides, Forskolin, Phospholipase C, Reverse Transcriptase Polymerase Chain Reaction, Kinase, Colforsin, Uterus, NF-kappa B, Obstetrics and Gynecology, Cell Biology, Isoquinolines, Endocrinology, Reproductive Medicine, chemistry, Female, Proto-Oncogene Proteins c-fos, Developmental Biology, Prostaglandin E
Abstract

Investigations of the modulation of prostaglandin F(2alpha) receptor (FP) expression in primary cultures of human uterine myocytes showed that FP mRNA expression was reduced by progesterone, unaltered by cAMP (8-bromo cAMP or forskolin), but increased by the PKA antagonist H89. Interleukin (IL)-1beta, tumour necrosis factor-alpha and oxytocin increased FP mRNA expression and IL-6 and prostaglandin E(2) reduced FP mRNA expression. The changes in FP protein levels were similar to the mRNA responses. We found that the IL-1beta-induced increase in FP expression was mediated at least in part via protein kinase C (PKC), but was independent of mitogen-activated protein kinase, phospholipase C and PI3 kinase. Since IL-1beta activates NFkappaB, AP-1 and C/EBP, we over-expressed these transcription factors alone and in combination and found that only NFkappaB alone increased FP mRNA expression. Finally, we found that the IL-1beta-induced increase in FP expression was unaffected by progesterone and/or cAMP, but was accentuated by H89. These data suggest that the pregnancy-induced down-regulation in myometrial FP expression is mediated by progesterone and cAMP and that the increase with labour is induced by inflammatory cytokine activation of PKC and NFkappaB.

Published
2008

6. P278 ASSESSMENT OF NUTRITIONAL STATUS IN IRANIAN HEMODIALYSIS PATIENTS

Author

D. Taheri, I. Shaygannia, A. Emami Naini, S. Khanjani, A.H. Keshteli, and J. Moghtaderi

Subjects
medicine.medical_specialty, Nutrition and Dietetics, business.industry, medicine.medical_treatment, medicine, Medicine (miscellaneous), Nutritional status, Hemodialysis, Critical Care and Intensive Care Medicine, Intensive care medicine, business
Published
2008

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