Author: "S. Ando" / Topic: medicine - Searchworks@Jio Institute Digital Library Search Results

85 results on '"S. Ando"'

1. Distinct Signaling Pathways Between Human Macrophages and Primary Gingival Epithelial Cells by Aggregatibacter actinomycetemcomitans

Author: Ellen S. Ando-Suguimoto, Manjunatha R. Benakanakere, Marcia P.A. Mayer, and Denis F. Kinane
Subjects: A. actinomycetemcomitans, inflammasome, immune response, periodontal disease, Medicine
Abstract: In aggressive periodontitis, the dysbiotic microbial community in the subgingival crevice, which is abundant in Aggregatibacter actinomycetemcomitans, interacts with extra- and intracellular receptors of host cells, leading to exacerbated inflammation and subsequent tissue destruction. Our goal was to understand the innate immune interactions of A. actinomycetemcomitans with macrophages and human gingival epithelial cells (HGECs) on the signaling cascade involved in inflammasome and inflammatory responses. U937 macrophages and HGECs were co-cultured with A. actinomycetemcomitans strain Y4 and key signaling pathways were analyzed using real-time PCR, Western blotting and cytokine production by ELISA. A. actinomycetemcomitans infection upregulated the transcription of TLR2, TLR4, NOD2 and NLRP3 in U937 macrophages, but not in HGECs. Transcription of IL-1β and IL-18 was upregulated in macrophages and HGECs after 1 h interaction with A. actinomycetemcomitans, but positive regulation persisted only in macrophages, resulting in the presence of IL-1β in macrophage supernatant. Immunoblot data revealed that A. actinomycetemcomitans induced the phosphorylation of AKT and ERK1/2, possibly leading to activation of the NF-κB pathway in macrophages. On the other hand, HGEC signaling induced by A. actinomycetemcomitans was distinct, since AKT and 4EBP1 were phosphorylated after stimulation with A. actinomycetemcomitans, whereas ERK1/2 was not. Furthermore, A. actinomycetemcomitans was able to induce the cleavage of caspase-1 in U937 macrophages in an NRLP3-dependent pathway. Differences in host cell responses, such as those seen between HGECs and macrophages, suggested that survival of A. actinomycetemcomitans in periodontal tissues may be favored by its ability to differentially activate host cells.
Published: 2020
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2. Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages.

Author: Bruno Bueno-Silva, Dione Kawamoto, Ellen S Ando-Suguimoto, Severino M Alencar, Pedro L Rosalen, and Marcia P A Mayer
Subjects: Medicine, Science
Abstract: Although previous studies suggested an anti-inflammatory property of Brazilian red propolis (BRP), the mechanisms involved in the anti-inflammatory effects of BRP and its activity on macrophages were still not elucidated. This study aimed to evaluate whether BRP attenuates the inflammatory effect of LPS on macrophages and to investigate its underlying mechanisms. BRP was added to RAW 264.7 murine macrophages after activation with LPS. NO production, cell viability, cytokines profile were evaluated. Activation of inflammatory signaling pathways and macrophage polarization were determined by RT-qPCR and Western blot. BRP at 50 μg/ml inhibited NO production by 78% without affecting cell viability. Cd80 and Cd86 were upregulated whereas mrc1 was down regulated by BRP indicating macrophage polarization at M1. BRP attenuated the production of pro-inflammatory mediators IL-12, GM-CSF, IFN-Ɣ, IL-1β in cell supernatants although levels of TNF- α and IL-6 were slightly increased after BRP treatment. Levels of IL-4, IL-10 and TGF-β were also reduced by BRP. BRP significantly reduced the up-regulation promoted by LPS of transcription of genes in inflammatory signaling (Pdk1, Pak1, Nfkb1, Mtcp1, Gsk3b, Fos and Elk1) and of Il1β and Il1f9 (fold-change rate > 5), which were further confirmed by the inhibition of NF-κB and MAPK signaling pathways. Furthermore, the upstream adaptor MyD88 adaptor-like (Mal), also known as TIRAP, involved in TLR2 and TLR4 signaling, was down- regulated in BRP treated LPS-activated macrophages. Given that BRP inhibited multiple signaling pathways in macrophages involved in the inflammatory process activated by LPS, our data indicated that BRP is a noteworthy food-source for the discovery of new bioactive compounds and a potential candidate to attenuate exhacerbated inflammatory diseases.
Published: 2015
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3. Effect of Probiotics Lactobacillus acidophilus and Lacticaseibacillus rhamnosus on Antibacterial Response Gene Transcription of Human Peripheral Monocytes

Author: Marcia Pinto Alves Mayer, Ellen S. Ando-Suguimoto, Brenda Izabela Santana Mota, and Glauber Campos Vale
Subjects: Antibacterial Response, Inflammation, Biology, Microbiology, Peripheral blood mononuclear cell, law.invention, Probiotic, Lactobacillus acidophilus, Multiplicity of infection, law, Gene expression, medicine, Molecular Medicine, ELISA, Tumor necrosis factor alpha, medicine.symptom, Molecular Biology
Abstract: Periodontitis and related systemic inflammatory diseases are characterized by imbalanced ratio between pro- and anti-inflammatory factors. Probiotics may control inflammation by altering the inflammatory phenotype of defense cells. We aimed to evaluate the gene transcription of the antibacterial response of monocytes to exposure to probiotic lactobacilli. CD14 + monocytes were obtained by positive selection from peripheral blood mononuclear cells from healthy donors (5 × 104 CD14 + /mL) and cultured with probiotic strains of Lacticaseibacillus rhamnosus (LR-32) and Lactobacillus acidophilus (LA-5) at a 1:10 multiplicity of infection in 24-well plates for 12 h. The gene expression analysis was performed by RT-qPCR using the Kit RT2 human antibacterial response, and in the supernatant, the cytokines were determined by ELISA. Tukey’s post hoc test following an ANOVA with a p value of 5% was used for statistical analysis. Both probiotic strains increased the levels of cytokines TNF-α and CXCL-8 in the supernatant compared to the control of non-challenged cells (p
Published: 2021

4. Impact of grip strength and balance function on the exercise capacity in pulmonary hypertension

Author: M Okamura, K Tamaura, Masaaki Konishi, T Nakamura, Teruyasu Sugano, Mina Nakayama, Naohiro Komura, Yusuke Saigusa, and S Ando
Subjects: medicine.medical_specialty, Cardiac output, Epidemiology, business.industry, Physical function, Exercise capacity, medicine.disease, Pulmonary hypertension, Preferred walking speed, Grip strength, medicine.anatomical_structure, Physical medicine and rehabilitation, Vascular resistance, Medicine, Cardiology and Cardiovascular Medicine, business, Balance (ability)
Abstract: Funding Acknowledgements Type of funding sources: None. 【Background】 Patients with pulmonary hypertension (PH) suffer from poor exercise capacity due to impaired oxygenation or reduced cardiac output. However, the relationship between exercise capacity and physical functions remains unclear. 【Purpose】 The purpose of this study is to investigate the relationship between exercise capacity and physical functions in pulmonary hypertension. 【Methods】 From February 2018 to June 2020, 94 patients (61.3 ± 14.7 years old, 69.1% females) with group 1/3/4/5 PH underwent cardiac catheterization, 6-minute walking distance (6MWD), and physical function measurements simultaneously. The physical functions was measured using muscle strength (grip strength, knee extension muscle strength), balance function (one leg standing time), and short physical performance battery (SPPB). Exercise capacity was measured by 6MWD. 【Results】 The study cohort consists of 22/8/60/4 (23.4%/8.5%/63.8%/4.3%) patients with group 1/3/4/5 PH, respectively. The average age of each group was 50.7/64.7/63.1/66.0 years old, respectively. A total of 194 measurements of physical functions were evaluated from 94 patients and employed in multivariate logistic regression analysis using adaptive-LASSO methods with the 6MWD (476.2 ± 107.5m) as a dependent variable. WHO functional class (class II: standardized β=-0.35, 95% confidence interval (CI) [-0.54 - -0.16], p 【Conclusions】 Grip strength and balance function, as well as SvO2 and PVR, were associated with the exercise capacity in pulmonary hypertension.
Published: 2021
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5. Impact of Blood Pressure Visit‐to‐Visit Variability on Adverse Events in Patients With Nonvalvular Atrial Fibrillation: Subanalysis of the J‐RHYTHM Registry

Author: Eitaro Kodani, Hiroshi Inoue, Hirotsugu Atarashi, Ken Okumura, Takeshi Yamashita, Toshiaki Otsuka, Hideki Origasa, H Inoue, K Okumura, H Atarashi, T Yamashita, M Sakurai, Y Kawamura, I Kubota, Y Kaneko, K Matsumoto, S Ogawa, Y Aizawa, I Kodama, E Watanabe, Y Koretsune, Y Okuyama, A Shimizu, O Igawa, S Bando, M Fukatani, T Saikawa, A Chishaki, H Origasa, N Kato, K. Kanda, J Kato, H Obata, M Aoki, H. Honda, Y Konta, T Hatayama, Y Abe, K Terata, T Yagi, A Ishida, T Komatsu, H Tachibana, H Suzuki, Y Kamiyama, T Watanabe, M Oguma, M Itoh, O Hirono, Y Tsunoda, K Ikeda, T Kanaya, K Sakurai, H Sukekawa, S Nakada, T Itoh, S Tange, M. Manita, M Ohta, H Eguma, R Kato, Y Endo, T Ogino, M Yamazaki, H Kanki, M Uchida, S Miyanaga, K Shibayama, N Toratani, T Kojima, M Ichikawa, M Saito, Y Umeda, T Sawanobori, H Sohara, S Okubo, T Okubo, T. Tokunaga, O Kuboyama, H Ito, Y Kitahara, K Sagara, T Satoh, E Kodani, K Sugi, Y Kobayashi, Y Higashi, T Katoh, Y Hirayama, N Matsumoto, M Takano, T Ikeda, S Yusu, S Niwano, Y Nakazato, Y Kawano, M Sumiyoshi, N Hagiwara, K Murasaki, H Mitamura, S Nakagawa, K Okishige, K Azegami, H Aoyagi, K Sugiyama, M Nishizaki, N Yamawake, I Watanabe, K Ohkubo, H Sakurada, S Fukamizu, M Suzuki, W Nagahori, T Nakamura, Y Murakawa, N Hayami, K Yoshioka, M Amino, K Hirao, A Yagishita, K Ajiki, K Fujiu, Y Imai, A Yamashina, T Ishiyama, M Sakabe, K Nishida, H Asanoi, H Ueno, null Lee, Y Mitsuke, H Furushima, K Ebe, M Tagawa, M Sato, M. Morikawa, K Yamashiro, K Takami, T Ozawa, M Watarai, M Yamauchi, H Kamiya, H. Hirayama, Y. Yoshida, T Murohara, Y Inden, H Osanai, N Ohte, T Goto, I Morishima, T Yamamoto, E Fujii, M Senga, H. Hayashi, T Urushida, Y Takada, N Tsuboi, T Noda, T Hirose, T Onodera, S Kageyama, T Osaka, T. Tomita, K Shimada, M Nomura, H Izawa, A Sugiura, T Arakawa, K. Kimura, T Mine, T Makita, H Mizuno, A Kobori, T Haruna, M Takagi, N Tanaka, H Shimizu, T Kurita, K Motoki, N Takeda, Y Kijima, M Ito, A Nakata, Y Ueda, A Hirata, S Kamakura, K Satomi, Y. Yamada, Y. Yoshiga, H Ogawa, M Kimura, T Hayano, T Kinbara, H Tatsuno, M Harada, K. Kusano, M Adachi, A Yano, M Sawaguchi, J Yamasaki, T Matsuura, Y Tanaka, H Moritani, T Maki, S Okada, M Takechi, T Hamada, A Nishikado, Y Takagi, I Matsumoto, T Soeki, Y Doi, M Okawa, H Seo, S Kitamura, K Yamamoto, M Akizawa, N Kaname, S Ando, S Narita, T Inou, Y Fukuizumi, K Saku, M Ogawa, Y Urabe, M Ikeuchi, S Harada, H Yamabe, Y Imamura, Y. Yamanouchi, K Sadamatsu, K Yoshida, T Kubota, N Takahashi, N Makino, Y Higuchi, T Ooie, T Iwao, K. Kitamura, T Imamura, K Maemura, N Komiya, M Hayano, H Yoshida, and K. Kumagai
Subjects: Male, medicine.medical_specialty, Hemorrhage, Risk Assessment, Rhythm, Japan, Risk Factors, Cause of Death, Thromboembolism, Internal medicine, Atrial Fibrillation, Ambulatory Care, medicine, Humans, Arrhythmia and Electrophysiology, In patient, Registries, Risk factor, Adverse effect, Original Research, Aged, Analysis of Variance, variability, Clinical events, business.industry, blood pressure, Anticoagulants, Blood Pressure Determination, Atrial fibrillation, medicine.disease, Blood pressure, major hemorrhage, Hypertension, Cardiology, Female, Warfarin, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors
Abstract: Background Blood pressure (BP) variability has reportedly been a risk factor for various clinical events. To clarify the influence of BP visit‐to‐visit variability on adverse events in patients with nonvalvular atrial fibrillation, a post hoc analysis of the J‐RHYTHM Registry was performed. Methods and Results Of 7406 outpatients with nonvalvular atrial fibrillation from 158 institutions, 7226 (age, 69.7±9.9 years; men, 70.7%), in whom BP was measured 4 times or more (14.6±5.0 times) during the 2‐year follow‐up period or until occurrence of an event, constituted the study group. SD and coefficient of variation of BP values were calculated as BP variability. Thromboembolism, major hemorrhage, and all‐cause death occurred in 110 (1.5%), 121 (1.7%), and 168 (2.3%) patients, respectively. When patients were divided into quartiles of systolic BP‐SD (P =0.015 for thromboembolism; HR, 2.60, 95% CI, 1.36–4.97, P =0.004 for major hemorrhage; and HR, 1.85, 95% CI, 1.11–3.07, P =0.018 for all‐cause death) after adjusting for components of the CHA 2 DS 2 ‐VASc score, warfarin and antiplatelet use, atrial fibrillation type, BP measurement times, and others. These findings were consistent when BP‐coefficient of variation was used instead of BP‐SD. Conclusions Systolic BP visit‐to‐visit variability was significantly associated with all adverse events in patients with nonvalvular atrial fibrillation. Further studies are needed to clarify the causality between BP variability and adverse outcomes in patients with nonvalvular atrial fibrillation. Registration URL: https://www.umin.ac.jp/ctr/ ; Unique Identifier: UMIN000001569.
Published: 2021
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6. Bifidobacterium strains present distinct effects on the control of alveolar bone loss in a periodontitis experimental model

Author: Natali Shimabukuro, Amália C. de S. Cataruci, Karin H. Ishikawa, Bruna E. de Oliveira, Dione Kawamoto, Ellen S. Ando-Suguimoto, Emmanuel Albuquerque-Souza, Jacques R. Nicoli, Caroline M. Ferreira, Jean de Lima, Manuela R. Bueno, Leandro B. R. da Silva, Pedro H. F. Silva, Michel R. Messora, Niels O. S. Camara, Maria Regina L. Simionato, and Marcia P. A. Mayer
Subjects: Population, RM1-950, Microbiology, Immune system, medicine, Pharmacology (medical), education, periodontitis, Porphyromonas gingivalis, PROBIÓTICOS, Dental alveolus, Original Research, Bifidobacterium, Periodontitis, Pharmacology, education.field_of_study, immune modulation, biology, Chemistry, biology.organism_classification, medicine.disease, TLR2, probiotics, Interaction with host, Therapeutics. Pharmacology, P. gingivalis
Abstract: Periodontitis is an inflammatory disease induced by a dysbiotic oral microbiome. Probiotics of the genus Bifidobacterium may restore the symbiotic microbiome and modulate the immune response, leading to periodontitis control. We evaluated the effect of two strains of Bifidobacterium able to inhibit Porphyromonas gingivalis interaction with host cells and biofilm formation, but with distinct immunomodulatory properties, in a mice periodontitis model. Experimental periodontitis (P+) was induced in C57Bl/6 mice by a microbial consortium of human oral organisms. B. bifidum 1622A [B+ (1622)] and B. breve 1101A [B+ (1101)] were orally inoculated for 45 days. Alveolar bone loss and inflammatory response in gingival tissues were determined. The microbial consortium induced alveolar bone loss in positive control (P + B-), as demonstrated by microtomography analysis, although P. gingivalis was undetected in oral biofilms at the end of the experimental period. TNF-α and IL-10 serum levels, and Treg and Th17 populations in gingiva of SHAM and P + B- groups did not differ. B. bifidum 1622A, but not B. breve 1101A, controlled bone destruction in P+ mice. B. breve 1101A upregulated transcription of Il-1β, Tnf-α, Tlr2, Tlr4, and Nlrp3 in P-B+(1101), which was attenuated by the microbial consortium [P + B+(1101)]. All treatments downregulated transcription of Il-17, although treatment with B. breve 1101A did not yield such low levels of transcripts as seen for the other groups. B. breve 1101A increased Th17 population in gingival tissues [P-B+ (1101) and P + B+ (1101)] compared to SHAM and P + B-. Administration of both bifidobacteria resulted in serum IL-10 decreased levels. Our data indicated that the beneficial effect of Bifidobacterium is not a common trait of this genus, since B. breve 1101A induced an inflammatory profile in gingival tissues and did not prevent alveolar bone loss. However, the properties of B. bifidum 1622A suggest its potential to control periodontitis.
Published: 2021

7. Distinct Signaling Pathways Between Human Macrophages and Primary Gingival Epithelial Cells by Aggregatibacter actinomycetemcomitans

Author: Denis F. Kinane, Marcia Pinto Alves Mayer, Manjunatha R. Benakanakere, and Ellen S. Ando-Suguimoto
Subjects: Microbiology (medical), medicine.medical_treatment, periodontal disease, lcsh:Medicine, Inflammation, immune response, Microbiology, Immune system, inflammasome, medicine, Immunology and Allergy, Molecular Biology, Innate immune system, General Immunology and Microbiology, biology, Chemistry, A. actinomycetemcomitans, lcsh:R, Aggregatibacter actinomycetemcomitans, Inflammasome, biology.organism_classification, TLR2, Infectious Diseases, Cytokine, TLR4, ELISA, medicine.symptom, medicine.drug
Abstract: In aggressive periodontitis, the dysbiotic microbial community in the subgingival crevice, which is abundant in Aggregatibacter actinomycetemcomitans, interacts with extra- and intracellular receptors of host cells, leading to exacerbated inflammation and subsequent tissue destruction. Our goal was to understand the innate immune interactions of A. actinomycetemcomitans with macrophages and human gingival epithelial cells (HGECs) on the signaling cascade involved in inflammasome and inflammatory responses. U937 macrophages and HGECs were co-cultured with A. actinomycetemcomitans strain Y4 and key signaling pathways were analyzed using real-time PCR, Western blotting and cytokine production by ELISA. A. actinomycetemcomitans infection upregulated the transcription of TLR2, TLR4, NOD2 and NLRP3 in U937 macrophages, but not in HGECs. Transcription of IL-1&beta, and IL-18 was upregulated in macrophages and HGECs after 1 h interaction with A. actinomycetemcomitans, but positive regulation persisted only in macrophages, resulting in the presence of IL-1&beta, in macrophage supernatant. Immunoblot data revealed that A. actinomycetemcomitans induced the phosphorylation of AKT and ERK1/2, possibly leading to activation of the NF-&kappa, B pathway in macrophages. On the other hand, HGEC signaling induced by A. actinomycetemcomitans was distinct, since AKT and 4EBP1 were phosphorylated after stimulation with A. actinomycetemcomitans, whereas ERK1/2 was not. Furthermore, A. actinomycetemcomitans was able to induce the cleavage of caspase-1 in U937 macrophages in an NRLP3-dependent pathway. Differences in host cell responses, such as those seen between HGECs and macrophages, suggested that survival of A. actinomycetemcomitans in periodontal tissues may be favored by its ability to differentially activate host cells.
Published: 2020

8. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

Author: Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. Akutsu, I. Takamura, F. Hoshino, N. Yokota, T. Iwao, K. Tsuchida, M. Takeuchi, Y. Hatori, Y. Kitami, Yoichi Nakamura, R. Oyama, M. Ageta, Hiroyuki Oda, Y. Go, K. Mishima, T. Unoki, S. Morii, Yuhei Shiga, H. Sumi, T. Nagatomo, K. Sanno, K. Fujisawa, Y. Atsuchi, T. Nagoshi, T. Seto, T. Tabuchi, M. Kameko, K. Nii, K. Oshiro, H. Takezawa, S. Nagano, N. Miyamoto, M. Iwaki, Yuichiro Nakamura, M. Fujii, M. Okawa, Masahiko Abe, Masatake Abe, Mitsunori Abe, T. Saito, T. Mito, K. Nagao, J. Minami, T. Mita, I. Sakuma, T. Taguchi, S. Marusaki, H. Doi, M. Tanaka, T. Fujito, M. Matsuta, T. Kusumoto, S. Kakinoki, K. Ashida, N. Yoshizawa, J. Agata, O. Arasaki, M. Manita, M. Ikemura, S. Fukuoka, H. Murakami, S. Matsukawa, Y. Hata, T. Taniguchi, T. Ko, H. Kubo, M. Imamaki, M. Akiyama, M. Inagaki, H. Odakura, T. Ueda, Y. Katsube, A. Nakata, H. Watanabe, M. Techigawara, M. Igarashi, K. Taga, T. Kimura, S. Tomimoto, M. Shibuya, M. Nakano, K. Ito, T. Seo, S. Hiramitsu, H. Hosokawa, M. Hoshiai, M. Hibino, K. Miyagawa, Hajime Horie, N. Sugishita, Yukio Shiga, A. Soma, K. Neya, Tetsuro Yoshida, Tomoki Yoshida, M. Mizuguchi, M. Ishiguro, T. Minagawa, M. Wada, H. Mukawa, F. Okuda, S. Nagasaka, Y. Abe, Sen Adachi, Susumu Adachi, T. Adachi, K. Akahane, T. Amano, K. Aoki, T. Aoyama, H. Arai, S. Arima, T. Arino, H. Asano, T. Asano, J. Azuma, T. Baba, T. Betsuyaku, H. Chibana, H. Date, J. Doiuchi, Y. Emura, M. Endo, Y. Fujii, R. Fujiki, A. Fujisawa, Y. Fujisawa, T. Fukuda, T. Fukui, N. Furukawa, T. Furukawa, W. Furumoto, T. Goto, M. Hamaoka, N. Hanazono, K. Hasegawa, T. Hatsuno, Y. Hayashi, K. Higuchi, K. Hirasawa, H. Hirayama, M. Hirose, S. Hirota, M. Honda, Hideki Horie, T. Ido, O. Iiji, H. Ikeda, K. Ikeda, K. Ikeoka, M. Imaizumi, H. Inaba, T. Inoue, F. Iseki, A. Ishihara, N. Ishioka, N. Ito, T. Iwase, H. Kakuda, J. Kamata, H. Kanai, H. Kanda, M. Kaneko, H. Kano, T. Kasai, T. Kato, Y. Kato, Y. Kawada, K. Kawai, K. Kawakami, S. Kawakami, T. Kawamoto, S. Kawano, J. Kim, T. Kira, H. 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A., Andersson, A., Malmqvist, L., Martinsson, B., Bernsten, F., Engdahl, J., Thulin, J., Hot-Bjelac, A., Stalby, P., Aaröe, H., Ahbeck, E., Ahlmark, H., Al-Khalili, F., Bonkowski, G., Dzeletovic, S., Ekstrand, A. -B., Eriksson, G. -B., Floren, K., Grässjö, C., Hahn, S., Jaensson, P., Jansson, B., Jansson, J. -H., Kangert, R. -M., Koch, A., Kusiak, D., Lettenström, A., Lindberg, A., Lindholm, C. -J., Mannermyr, A., Mansson, K., Millborg, M., Nilsson, C., Ohlin, A. -M., Olofsson, A., Osberg, A., Pedersen, A., Risbecker, K., Rosenberg, K., Samuelsson, J., Shayesteh, M., Skoglund, K., Stjernberg, M., Thorsen, C., Steffel, J., Beer, J. H., Debrunner, J., Amstutz, D., Bruegger, J., Elise, G., Grau, A., Guinand, A., Henriette, I., Saga, E., Winnik, S., Parkhomenko, A., Rudyk, I., Tseluyko, V., Karpenko, O., Zhurba, S., Kraiz, I., Kupnovytska, I., Serediuk, N., Mostovoy, Y., Ushakov, O., Koval, O., Kovalskyi, I., Svyshchenko, Y., Sychov, O., Stanislavchuk, M., Kraydashenko, O., Yagensky, A., Tykhonova, S., Fushtey, I., Belegai, R., Berko, G., Burdeuna, L., Chabanna, O., Daniuk, I., Ivanov, A., Kamenska, E., Kaplan, P., Khyzhnyak, O., Kizim, S., Matova, O., Medentseva, O., Mochonyi, V., Mospan, M., Nemtsova, V., Ovdiienko, T., Palamarchuk, O., Pavelko, M., Petrovskyy, R., Plevak, D., Proshak, O., Pyvovar, S., Rasputina, L., Romanenko, O., Romanova, O., Sapatyi, A., Shumakov, O., Stets, R., Todoriuk, L., Varenov, V., Fitzmaurice, D., Chauhan, N., Goodwin, D., Saunders, P., Evans, R., Leese, J., Jhittay, P. S., Ross, A., Kainth, M. S., Pickavance, G., Mcdonnell, J., Williams, A., Gooding, T., Wagner, H., Suryani, S., Singal, A., Sircar, S., Bilas, R., Hutchinson, P., Wakeman, A., Stokes, M., Paul, N., Aziz, M., Ramesh, C., Wilson, P., Franklin, S., Fairhead, S., Thompson, J., St Joseph, V., Taylor, G., Tragen, D., Seamark, D., Paul, C., Richardson, M., Jefferies, A., Sharp, H., Jones, H., Giles, C., Page, M., Oginni, O., Aldegather, J., Wetherwell, S., Lumb, W., Evans, P., Scouller, F., Macey, N., Stipp, Y., West, R., Thurston, S., Wadeson, P., Matthews, J., Pandya, P., Gallagher, A., Railton, T., Sinha, B., Russell, D., Davies, J. A., Ainsworth, P., Jones, C. P., Weeks, P., Eden, J., Kernick, D., Murdoch, W., Lumley, L., Patel, R. P., Wong, S. W., Saigol, M., Ladha, K., Douglas, K., Cumberlidge, D. F., Bradshaw, C., Van Zon, G., Jones, K. P., Thomas, M. J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R. T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., Mcginty, P., Wastling, R., Mceleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P. B., Seamark, C., Shewring, J., Simmons, P., Simper, H., Stoddart, H., Sword, A., Thomas, N., Thomson, A., Gibbs, H., Blenkhorn, A., Singh, B., Van Gaal, W., Abhayaratna, W., Lehman, R., Roberts-Thomson, P., Kilian, J., Coulshed, D., Catanchin, A., Colquhoun, D., Kiat, H., Eccleston, D., French, J., Zimmett, L., Ayres, B., Phan, T., Blombery, P., Crimmins, D., O'Donnell, D., Choi, A., Astridge, P., Arstall, M., Jepson, N., Binnekamp, M., Lee, A., Rogers, J., Starmer, G., Carroll, P., Faunt, J., Aggarwala, A., Barry, L., Batta, C., Beveridge, R., Black, A., Bonner, M., Boys, J., Buckley, E., Campo, M., Carlton, L., Connelly, A., Conway, B., Cresp, D., Dimitri, H., Dixon, S., Dolman, M., Duroux, M., Eskandari, M., Eslick, R., Ferreira-Jardim, A., Fetahovic, T., Fitzpatrick, D., Geraghty, R., Gibbs, J., Grabek, T., Modi, M. H., Hayes, K., Hegde, M. P., Hesketh, L., Hoffmann, B., Jacobson, B., Johnson, K., Juergens, C., Kassam, I., Lawlor, V., Lehman, M., Lehman, S., Leung, D., Mackay, S., Mackenzie, M., Mccarthy, C., Mcintosh, C., Mckeon, L., Morrison, H., Mussap, C., Myers, J. -D., Nagalingam, V., Oldfield, G., O'May, V., Palmer, J., Parsons, L., Patching, K., Patching, T., Paul, V., Plotz, M., Preston, S., Rashad, H., Ratcliffe, M., Raynes, S., Rose, J., Sanders, L., Seremetkoska, M., Setio, H., Shone, S., Shrestha, P., Singh, C., Singleton, C., Stoyanov, N., Sutcliffe, S., Swaraj, K., Tarrant, J., Thompson, S., Tsay, I. M., Vorster, M., Waldman, A., Wallis, L., Wilford, E., Wong, K., Connolly, S. J., Spyropoulos, A., Eikelboom, J., Luton, R., Gupta, M., Pandey, A. S., Cheung, S., Leader, R., Beaudry, P., Ayala-Paredes, F., Berlingieri, J., Heath, J., Poirier, G., Du Preez, M., Nadeau, R., Dresser, G., Dhillon, R., Hruczkowski, T., Schweitzer, B., Coutu, B., Angaran, P., Macdonald, P., Vizel, S., Fikry, S., Parkash, R., Lavoie, A., Cha, J., Ramjattan, B., Bonet, J., Ahmad, K., Aro, L., Aves, T., Beaudry, K., Bergeron, C., Bigcanoe, J., Bignell, N., Breakwell, L., Burke, E., Carroll, L., Clarke, B., Cleveland, T., Daheb, S., Dehghani, P., Denis, I., Djaidani, Z., Dorian, P., Douglass, S., Dunnigan, J., Ewert, A., Farquhar, D., Fearon, A., Ferleyko, L., Fournier, D., Fox, B., Grenier, M. -C., Gulliver, W., Haveman, K., Hines, C., Hines, K., Jackson, A. M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., Ragy, H., Abd El-Aziz, A., Abou Seif, S. K., El Din, M. G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., Ahmed, F., Engelbrecht, J., Ramdass, A., Maharajh, S., Oosthuysen, W., Angel, G., Bester, C., Booysen, M., Boshoff, C., Cannon, C., Cassimjee, S., Chami, C., Conway, G., Davids, A., de Meyer, L., Du Plessis, G., Ellis, T., Henley, L., Karsten, M., Loyd, E., Marks, J., Mavhusa, L., Mostert, M., Page, A., Rikhotso, L., Salie, M., Sasto, J., Shaik, F., Skein, A., Smith, L., Tarr, G., Tau, T., van Zyl, F., Al Mahmeed, W., Yousef, G., Agrawal, A., Nathani, M., Ibrahim, M., Esheiba, E. M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Goldhaber, S. Z., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W. M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., Depauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J. A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
Subjects: Registrie, Male, Time Factors, Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF, 030204 cardiovascular system & hematology, Electrocardiography, 0302 clinical medicine, Risk Factors, Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF, Aged, Atrial Fibrillation, Female, Follow-Up Studies, Humans, Incidence, India, Prevalence, Prognosis, Prospective Studies, Survival Rate, Thromboembolism, Registries, Risk Assessment, Medicine, 030212 general & internal medicine, Prospective cohort study, Incidence (epidemiology), cardiovascular system, medicine.symptom, Cardiology and Cardiovascular Medicine, Risk assessment, Human, medicine.medical_specialty, Time Factor, RD1-811, Prognosi, Follow-Up Studie, 03 medical and health sciences, Internal medicine, Diseases of the circulatory (Cardiovascular) system, cardiovascular diseases, Risk factor, Survival rate, Fibrillation, business.industry, Risk Factor, ta3121, medicine.disease, Clinical trial, Prospective Studie, RC666-701, Surgery, Clinical and Preventive Cardiology, business
Abstract: Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
Published: 2018
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9. Probiotics alter the immune response of gingival epithelial cells challenged byPorphyromonas gingivalis

Author: Marcia Pinto Alves Mayer, Maria Regina Lorenzetti Simionato, Emmanuel Albuquerque-Souza, Marinella Holzhausen, Ellen S. Ando-Suguimoto, Danilo Balzarini, and Karin Hitomi Ishikawa
Subjects: 0301 basic medicine, Interleukin-1beta, Gingiva, Inflammation, Biology, Microbiology, law.invention, 03 medical and health sciences, Probiotic, 0302 clinical medicine, Multiplicity of infection, Immune system, law, Antibiosis, medicine, Humans, Interleukin 8, Periodontitis, Porphyromonas gingivalis, Cells, Cultured, Innate immune system, Tumor Necrosis Factor-alpha, Probiotics, Interleukin-8, Epithelial Cells, 030206 dentistry, biology.organism_classification, Immunity, Innate, Toll-Like Receptor 4, Lactobacillus, TLR2, 030104 developmental biology, Cellular Microenvironment, Periodontics, Bifidobacterium, medicine.symptom
Abstract: Background and objective Although previous studies revealed the potential use of probiotics in the control of periodontitis, little is known about their interactions with gingival epithelial cells (GECs). Since GECs comprise the first defense in the subgingival microenvironment, the aim of this study was to evaluate the effect of probiotic lactobacilli and bifidobacteria strains on OBA-9 cells challenged with Porphyromonas gingivalis. Methods Immortalized human GECs (OBA-9) were challenged with live P. gingivalis (strains W83 and ATCC33277) and co-infected with one of 12 tested probiotic strains at a multiplicity of infection (MOI) of 1:1000 for 2 hours. Bacterial adhesion and invasion were determined by antibiotic exclusion analysis and CFU counting. OBA-9 viability was assessed by MTT assay, and levels of inflammatory mediators (TNF-α, IL-1β, and CXCL8) in the supernatants were determined by ELISA. The expression of genes encoding Toll-like receptors (TLR2, TLR4) was evaluated by RT-qPCR. Results Both strains of P. gingivalis were able to adhere and invade OBA-9 cells, with significant loss in cell viability, increase in the levels of TNF-α and IL-1β, and upregulation of TLR4. However, co-infection with probiotics attenuated these effects in P. gingivalis challenged GECs. Most probiotics maintained OBA-9 viability and reduced pathogens adhesion and invasion. Furthermore, probiotics were able to adhere to GECs, which was enhanced for most strains in the presence of P. gingivalis. The synthesis of IL-1β and TNF-α by P. gingivalis in challenged GECs was reduced in co-culture with most of the tested probiotics, whereas the secretion of CXCL8 increased, and TLR4 was downregulated. Conclusion Probiotics can alter the interaction of GECs with P. gingivalis by modulating the pathogen's ability to adhere and invade these cells, as well as by regulating the innate immune response. Such properties are strain-specific and may indicate the most efficient probiotics to control periodontitis.
Published: 2018
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10. Brazilian red propolis effects on peritoneal macrophage activity: nitric oxide, cell viability, pro-inflammatory cytokines and gene expression

Author: Pedro Luiz Rosalen, Severino Matias de Alencar, Renato Corrêa Viana Casarin, Ellen S. Ando-Suguimoto, Marcia Pinto Alves Mayer, Bruno Bueno-Silva, and Dione Kawamoto
Subjects: 0301 basic medicine, Lipopolysaccharides, Cell Survival, medicine.medical_treatment, PRÓPOLIS, Anti-Inflammatory Agents, Inflammation, Pharmacology, Biology, Nitric Oxide, Propolis, Proinflammatory cytokine, 03 medical and health sciences, Mice, 0302 clinical medicine, Drug Discovery, medicine, Macrophage, Animals, SOCS3, Viability assay, Mice, Inbred C57BL, 030104 developmental biology, Cytokine, Gene Expression Regulation, 030220 oncology & carcinogenesis, Immunology, Macrophages, Peritoneal, Cytokines, Tumor necrosis factor alpha, medicine.symptom, Brazil
Abstract: Ethnopharmacological relevance Propolis has been used in folk medicine since ancient times and it presented inhibitory effect on neutrophil recruitment previously. However, its effect on macrophage obtained from mice remains unclear. Aim of the study To demonstrate BRP effects on LPS activated peritoneal macrophage. Materials and Methods Peritoneal macrophages, obtained from C57BL6 mice and activated with LPS, were treated with 50–80 µg/mL of crude extract of Brazilian red propolis (BRP) during 48 h. Cell viability, levels of NO, 20 cytokines and expression of 360 genes were evaluated. Results BRP 60 µg/mL reduced NO production by 65% without affecting the cell viability and decreased production IL1α, IL1β, IL4, IL6, IL12p40, Il12p70, IL13, MCP1 and GM-CSF. Molecular mechanism beyond the anti-inflammatory activity may be due to BRP-effects on decreasing expression of Mmp7, Egfr, Adm, Gata3, Wnt2b, Txn1, Herpud1, Axin2, Car9, Id1, Vegfa, Hes1, Hes5, Icam1, Wnt3a, Pcna, Wnt5a, Tnfsf10, Ccl5, Il1b, Akt1, Mapk1, Noxa1 and Cdkn1b and increasing expression of Cav1, Wnt6, Calm1, Tnf, Rb1, Socs3 and Dab2 . Conclusions Therefore, BRP has anti-inflammatory effects on macrophage activity by reducing NO levels and diminished release and expression of pro-inflammatory cytokine and genes, respectively.
Published: 2017

11. The cytolethal distending toxin of Aggregatibacter actinomycetemcomitans inhibits macrophage phagocytosis and subverts cytokine production

Author: Maike Paulino da Silva, Ellen S. Ando-Suguimoto, Marcia Pinto Alves Mayer, Dione Kawamoto, Joseph M. DiRienzo, and Casey Chen
Subjects: Cytolethal distending toxin, Cell Survival, Phagocytosis, medicine.medical_treatment, Bacterial Toxins, Immunology, Colony Count, Microbial, Intracellular Space, Virulence, Biology, Nitric Oxide, medicine.disease_cause, Aggregatibacter actinomycetemcomitans, Biochemistry, Cell Line, Microbiology, Mice, Immune system, medicine, Animals, Immunology and Allergy, Macrophage, Molecular Biology, Toxin, Macrophages, MICROBIOLOGIA, Hematology, biology.organism_classification, Cytokine, Cytokines, Subcellular Fractions
Abstract: Aggregatibacter actinomycetemcomitans is an important periodontal pathogen that can participate in periodontitis and other non-oral infections. The cytolethal distending toxin (Cdt) is among the virulence factors produced by this bacterium. The Cdt is also secreted by several mucosa-associated Gram-negative pathogens and may play a role in perpetuating the infection by modulating the immune response. Although the toxin targets a wide range of eukaryotic cell types little is known about its activity on macrophages which play a key part in alerting the rest of the immune system to the presence of pathogens and their virulence factors. In view of this, we tested the hypothesis that the A. actinomycetemcomitans Cdt (AaCdt) disrupts macrophage function by inhibiting phagocytic activity as well as affecting the production of cytokines. Murine macrophages were co-cultured with either wild-type A. actinomycetemcomitans or a Cdt(-) mutant. Viable counts and qPCR showed that phagocytosis of the wild-type strain was significantly reduced relative to that of the Cdt(-) mutant. Addition of recombinant Aa(r)Cdt to co-cultures along with the Cdt(-) mutant diminished the phagocytic activity similar to that observed with the wild type strain. High concentrations of Aa(r)Cdt resulted in decreased phagocytosis of fluorescent bioparticles. Nitric oxide production was modulated by the presence of Cdt and the levels of IL-1β, IL-12 and IL-10 were increased. Production of TNF-α did not differ in the co-culture assays but was increased by the presence of Aa(r)Cdt. These data suggest that the Cdt may modulate macrophage function in A. actinomycetemcomitans infected sites by impairing phagocytosis and modifying the pro-inflammatory/anti-inflammatory cytokine balance.
Published: 2014
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12. Dermoscopic features of tungiasis

Author: K. Yamano, Hajime Miyazawa, Takamasa Ito, S. Ando, Masumi Tsujiwaki, Hideyuki Kosumi, Yosuke Mai, Hiroshi Shimizu, and Hiroaki Iwata
Subjects: medicine.medical_specialty, business.industry, MEDLINE, Dermatology, medicine.disease, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, medicine, 030212 general & internal medicine, Tungiasis, business
Published: 2018
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13. Impact of Blood Pressure Control on Thromboembolism and Major Hemorrhage in Patients With Nonvalvular Atrial Fibrillation: A Subanalysis of the J‐RHYTHM Registry

Author: Eitaro Kodani, Hirotsugu Atarashi, Hiroshi Inoue, Ken Okumura, Takeshi Yamashita, Toshiaki Otsuka, Hirofumi Tomita, Hideki Origasa, M. Sakurai, Y. Kawamura, I. Kubota, Y. Kaneko, K. Matsumoto, S. Ogawa, Y. Aizawa, I. Kodama, E. Watanabe, Y. Koretsune, Y. Okuyama, A. Shimizu, O. Igawa, S. Bando, M. Fukatani, T. Saikawa, A. Chishaki, N. Kato, K. Kanda, J. Kato, H. Obata, M. Aoki, H. Honda, Y. Konta, T. Hatayama, Y. Abe, K. Terata, T. Yagi, A. Ishida, T. Komatsu, H. Tachibana, H. Suzuki, Y. Kamiyama, T. Watanabe, M. Oguma, M. Itoh, O. Hirono, Y. Tsunoda, K. Ikeda, T. Kanaya, K. Sakurai, H. Sukekawa, S. Nakada, T. Itoh, S. Tange, M. Manita, M. Ohta, H. Eguma, R. Kato, Y. Endo, T. Ogino, M. Yamazaki, H. Kanki, M. Uchida, S. Miyanaga, K. Shibayama, N. Toratani, T. Kojima, M. Ichikawa, M. Saito, Y. Umeda, T. Sawanobori, H. Sohara, S. Okubo, T. Okubo, T. Tokunaga, O. Kuboyama, H. Ito, Y. Kitahara, K. Sagara, T. Satoh, K. Sugi, Y. Kobayashi, Y. Higashi, T. Katoh, Y. Hirayama, N. Matsumoto, M. Takano, T. Ikeda, S. Yusu, S. Niwano, Y. Nakazato, Y. Kawano, M. Sumiyoshi, N. Hagiwara, K. Murasaki, H. Mitamura, S. Nakagawa, K. Okishige, K. Azegami, H. Aoyagi, K. Sugiyama, M. Nishizaki, N. Yamawake, I. Watanabe, K. Ohkubo, H. Sakurada, S. Fukamizu, M. Suzuki, W. Nagahori, T. Nakamura, Y. Murakawa, N. Hayami, K. Yoshioka, M. Amino, K. Hirao, A. Yagishita, K. Ajiki, K. Fujiu, Y. Imai, A. Yamashina, T. Ishiyama, M. Sakabe, K. Nishida, H. Asanoi, H. Ueno, J. D. Lee, Y. Mitsuke, H. Furushima, K. Ebe, M. Tagawa, M. Sato, M. Morikawa, K. Yamashiro, K. Takami, T. Ozawa, M. Watarai, M. Yamauchi, H. Kamiya, H. Hirayama, Y. Yoshida, T. Murohara, Y. Inden, H. Osanai, N. Ohte, T. Goto, I. Morishima, T. Yamamoto, E. Fujii, M. Senga, H. Hayashi, T. Urushida, Y. Takada, N. Tsuboi, T. Noda, T. Hirose, T. Onodera, S. Kageyama, T. Osaka, T. Tomita, K. Shimada, M. Nomura, H. Izawa, A. Sugiura, T. Arakawa, K. Kimura, T. Mine, T. Makita, H. Mizuno, A. Kobori, T. Haruna, M. Takagi, N. Tanaka, H. Shimizu, T. Kurita, K. Motoki, N. Takeda, Y. Kijima, M. Ito, A. Nakata, Y. Ueda, A. Hirata, S. Kamakura, K. Satomi, Y. Yamada, Y. Yoshiga, H. Ogawa, M. Kimura, T. Hayano, T. Kinbara, H. Tatsuno, M. Harada, K. F. Kusano, M. Adachi, A. Yano, M. Sawaguchi, J. Yamasaki, T. Matsuura, Y. Tanaka, H. Moritani, T. Maki, S. Okada, M. Takechi, T. Hamada, A. Nishikado, Y. Takagi, I. Matsumoto, T. Soeki, Y. Doi, M. Okawa, H. Seo, S. Kitamura, K. Yamamoto, M. Akizawa, N. Kaname, S. Ando, S. Narita, T. Inou, Y. Fukuizumi, K. Saku, M. Ogawa, Y. Urabe, M. Ikeuchi, S. Harada, H. Yamabe, Y. Imamura, Y. Yamanouchi, K. Sadamatsu, K. Yoshida, T. Kubota, N. Takahashi, N. Makino, Y. Higuchi, T. Ooie, T. Iwao, K. Kitamura, T. Imamura, K. Maemura, N. Komiya, M. Hayano, H. Yoshida, and K. Kumagai
Subjects: Male, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, hypertension, medicine.drug_class, Diastole, Hemorrhage, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Japan, Risk Factors, Internal medicine, Odds Ratio, Medicine, Humans, Arrhythmia and Electrophysiology, atrial fibrillation, 030212 general & internal medicine, Prospective Studies, Registries, Risk factor, Antihypertensive drug, anticoagulation, Antihypertensive Agents, Original Research, Ischemic Stroke, Intracranial Hemorrhage, Aged, Proportional Hazards Models, business.industry, Hazard ratio, Warfarin, blood pressure, Atrial fibrillation, Odds ratio, Middle Aged, thromboembolism, medicine.disease, Blood pressure, High Blood Pressure, lcsh:RC666-701, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: Background To clarify the influence of hypertension and blood pressure ( BP ) control on thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation, a post hoc analysis of the J‐ RHYTHM Registry was performed. Methods and Results A consecutive series of outpatients with atrial fibrillation was enrolled from 158 institutions. Of 7937 patients, 7406 with nonvalvular atrial fibrillation (70.8% men, 69.8±10.0 years) were followed for 2 years or until an event occurred. Hypertension was defined as a systolic BP ≥140 mm Hg, a diastolic BP ≥90 mm Hg, a history of hypertension, and/or antihypertensive drug use. Hypertension was an independent risk factor for major hemorrhage (hazard ratio 1.52, 95% CI 1.05–2.21, P =0.027) but not for thromboembolism (hazard ratio 1.05, 95% CI 0.73–1.52, P =0.787). When patients were divided into quartiles according to their systolic BP at the time closest to the event or at the end of follow‐up (Q1, CI 1.75–4.74, P CI 1.02–2.53, P =0.041) after adjustment for components of CHA 2 DS 2 ‐ VAS c score, warfarin use, and antiplatelet use. A systolic BP of ≥136 mm Hg was an independent risk factor for thromboembolism and major hemorrhage. Conclusions BP control appears to be more important than a history of hypertension and baseline BP values at preventing thromboembolism and major hemorrhage in patients with nonvalvular atrial fibrillation. Clinical Trial Registration URL : http://www.umin.ac.jp/ctr . Unique identifier: UMIN 000001569.
Published: 2016

14. Porphyromonas gingivalis infection at different gestation periods on fetus development and cytokines profile

Author: S R R Lucas, S. R. L. Teixeira, Marcia Pinto Alves Mayer, M C A N Michelin, and Ellen S. Ando-Suguimoto
Subjects: Fetus, Pregnancy, biology, medicine.medical_treatment, Gestational age, medicine.disease, biology.organism_classification, Andrology, Cytokine, medicine.anatomical_structure, Otorhinolaryngology, Placenta, embryonic structures, Immunology, medicine, Gestation, Tumor necrosis factor alpha, General Dentistry, Porphyromonas gingivalis
Abstract: Oral Diseases (2012) 18, 648–654 Aim: Infective agents may affect pregnancy outcomes by deregulating homeostasis. Objectives: The effects of Porphyromonas gingivalis infection before and at different gestation periods were evaluated. Materials and Methods: Wistar rats infected via subcutaneous with P. gingivalis W83, one week before mating (BM), days 1 (PR1) and 11 of gestation (PR11), and controls were evaluated, and samples were obtained at the end of gestation. P. gingivalis was detected by PCR. Cytokine was determined by ELISA. Results: Infected rats had lower maternal gain of weight. Implantation was not observed in 2/12 BM rats. PR11 presented more fetal-placental resorptions and lower placenta/fetus weight than controls. P. gingivalis was detected in placenta and fetus. IL-6 and TNF-α levels were higher in placenta and serum of infected groups, except for TNF-α in placenta of PR1. IL-1β levels were higher in placenta of PR11, but lower in serum and placenta of PR1. There were no differences in IL-10 and PGE2 concentrations among the groups (P
Published: 2012
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15. Signaling transduction analysis in gingival epithelial cells after infection with Aggregatibacter actinomycetemcomitans

Author: Marcia Pinto Alves Mayer, Donald R. Demuth, J. E. Umeda, E. S. Ando, and Marcelo Faveri
Subjects: Microbiology (medical), medicine.medical_treatment, Immunology, Aggregatibacter actinomycetemcomitans, Biology, Colony-stimulating factor, biology.organism_classification, medicine.disease, Microbiology, Epithelium, Granulocyte macrophage colony-stimulating factor, Cytokine, medicine.anatomical_structure, medicine, Aggressive periodontitis, Tumor necrosis factor alpha, Signal transduction, General Dentistry, medicine.drug
Abstract: Summary Periodontal diseases result from the interaction of bacterial pathogens with the host’s gingival tissue. Gingival epithelial cells are constantly challenged by microbial cells and respond by altering their transcription profiles, inducing the production of inflammatory mediators. Different transcription profiles are induced by oral bacteria and little is known about how the gingival epithelium responds after interaction with the periodontopathogenic organism Aggregatibacter actinomycetemcomitans. In the present study, we examined the transcription of genes involved in signaling transduction pathways in gingival epithelial cells exposed to viable A. actinomycetemcomitans. Immortalized gingival epithelial cells (OBA-9) were infected with A. actinomycetemcomitans JP2 for 24 h and the transcription profile of genes encoding human signal transduction pathways was determined. Functional analysis of inflammatory mediators positively transcribed was performed by ELISA in culture supernatant and in gingival tissues. Fifteen of 84 genes on the array were over-expressed (P
Published: 2011
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16. Intracellular bacteria recognition contributes to maximal interleukin (IL)-12 production by IL-10-deficient macrophages

Author: J. E. Chang, K. Arai, Y. Yamauchi, Tadakazu Hisamatsu, Mina T. Kitazume, S. Ando, Toshifumi Hibi, Nobuhiko Kamada, Takanori Kanai, H. Naruse, and Katsuyoshi Matsuoka
Subjects: Lipopolysaccharides, Translational Studies, Lipopolysaccharide, medicine.medical_treatment, Phagocytosis, Blotting, Western, Immunology, Bone Marrow Cells, Biology, Interferon-gamma, Mice, Abstracts, chemistry.chemical_compound, Escherichia coli, medicine, Animals, Immunology and Allergy, STAT1, Phosphorylation, Cells, Cultured, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Macrophages, Interleukin, T helper cell, Interleukin-12, Interleukin-10, Mice, Inbred C57BL, Interleukin 10, STAT1 Transcription Factor, Cytokine, medicine.anatomical_structure, chemistry, Protein Biosynthesis, Host-Pathogen Interactions, biology.protein, Interleukin 12, Signal Transduction
Abstract: Summary Interleukin (IL)-12 is a key factor that induces T helper cell type 1-mediated immunity and inflammatory diseases. In some colitis models, such as IL-10 knock-out (KO) mice, IL-12 triggers intestinal inflammation. An abundant amount of IL-12 is produced by intestinal macrophages in response to stimulation by commensal bacteria in IL-10 KO mice. Intact bacteria are more potent inducers of macrophage IL-12 production than cell surface components in this model. This suggested that cell surface receptor signalling and intracellular pathogen recognition mechanisms are important for the induction of IL-12. We addressed the importance of intracellular recognition mechanisms and demonstrated that signal transducers and activator of transcription 1 (STAT1) signalling activated bacterial phagocytosis and was involved in the induction of abnormal IL-12 production. In IL-10 KO mouse bone marrow-derived (BM) macrophages, Escherichia coli stimulation induced increased IL-12p70 production compared to lipopolysaccharide combined with interferon (IFN)-γ treatment. Significant repression of IL-12 production was achieved by inhibition of phagocytosis with cytochalasin D, and inhibition of de novo protein synthesis with cycloheximide. Induction of IFN regulatory factors-1 and -8, downstream molecules of STAT1 and the key transcription factors for IK-12 transcription, following E. coli stimulation, were mediated by phagocytosis. Interestingly, STAT1 was activated after stimulation with E. coli in IL-10 KO BM macrophages, although IFN-γ could not be detected. These data suggest that molecules other than IFN-γ are involved in hyper-production mechanisms of IL-12 induced by E. coli stimulation. In conclusion, enteric bacteria stimulate excessive IL-12p70 production in IL-10 KO BM macrophages via phagocytosis-dependent signalling.
Published: 2011
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17. SLE and other connective tissue diseases (human studies) (PP-016)

Author: H. Iwao, F. Medina Rodríguez, M. Patwardhan, R. Alimohammadi, P. A. Mathew, N. Lotfi, H. Jo, H. Umehara, J. Shariati, K. Azuma, C. Aoki, Z. Yang, S. H. Park, T. Odani, M. Takei, E. S. Kozlova, C. Yu, Y. Adachi, C. Tsai, B. J. Prakken, D. Shah, A. Kozlowska, Z. Bahloul, Y. Matsukawa, D. Lindau, K. Nozawa, M. Narazaki, N. Kitamura, D. Kurosaka, M. Ushikubo, F. Fakhfakh, M Akbarian, J. Tsai, H. Inomata, S. Ando, K. Li, Y. Kuwana, A. Nadkarni, M. Wittmann, V. D. Pradhan, T. Watanabe, Y. M. Heo, H. Sugino, I. Kingetsu, I. Tanaka, S. Yasuda, H. Lee, B. Devi, T. Ishii, C. Chou, A. Bhatnagar, Y. M. Chen, I. M. Krivolapova, Y. Naishiro, S. Kao, T. Kato, R. Kiran, B. Chiang, T. Kawanami, H. Masmoudi, M. K. Park, Y. Nakiri, N. Ikumi, M. Kato, B. Shi, I. Sekigawa, H. Yamada, J. Moreno Rodríguez, N. Kang, J. Moradabbasi, T. Matsuda, A. Yamada, A. Morishima, S. Lassoued, K. S. Park, R. van der Zee, H. Baek, S. Lee, H. Y. Kim, C. C. Tsai, Y. Masaki, Z. Gheflati, Y. Liang, J. Zeitvogel, M. Miki, I. A. Pashnina, M. Ben Ahmed, M. Kawai, H. Murota, M. Kawasaki, A. Mackiewicz, X. Wang, B. Eiz-Vesper, R. Ben Mansour, E. C. Koffeman, J. Yasuda, H. Kataoka, S. Marzouk, Y. Shima, T. Kurita, H. Choi, T. Hirano, Y. Hori, N. Suematsu, T. Fukushima, M. Lin, M. Shiozaki, R. K. Patel, T. Werfel, M. Hatef, M. Ohkubo, J. R. Kim, B. S. Tzang, J. Y. Jhun, T. Yabuki, J. Arimitsu, M. Tanaka, F. Broere, S. Saito, O. V. Skorobogatova, K. Minowa, M. L. Cho, T. Fujii, A. Elbeldi-Ferchiou, L. Cui, N. Tabasi, K. Hagihara, T. Koike, H. Attia, J. Wang, S. Haddouk, M. Yagita, D. Y. Chen, H. Hsin, H. Nakano, Z. Jin, Y. Takasaki, K. Ohmura, T. Wu, L. Wang, A. Ogata, K. Gomi, H. Shiraiwa, K. Y. Kang, A. van Royen-Kerkhof, M. Yamamoto, T. C. Hsu, H. Takahashi, K. Masuko, S. Ozaki, K. Yoshida, D. Kawabata, Shahrzad Khosravi, T. Sakai, P. P. Jagodzinski, T. Nojima, Z. Huang, Y. Yamasaki, F. van Wijk, J. L. Lan, R. M. Pertusi, T. Tanaka, S. Liu, H. Ogawa, H. Louzir, C. Zhang, K. Yasui, T. Atsumi, K. Bamdad Mehrbany, H. Amano, H. J. Oh, R. Dressel, B. Yousefi, M. Yanagimachi, K. Akiya, Y. Sakata, Z. Tian, K. Imai, H. O. Kim, Y. Yang, Y. Seo, N. Yukawa, G. L. Ramírez Vélez, T. Mimori, A. Han, T. Sawaki, E. F. Elst, H. Houman, A. Aggarwal, Y. Fujita, Y. Tokano, M. Mahmoudi, C. Suzuki, S. O. Mathew, K. Ghosh, T. Nozaki, M. Obara, M. Seo, M. Mizushima, W. Wang, T. Horita, T. Tabeya, S. Morimoto, K. Otomo, M. S. Kurokawa, W. Liang, Mansour Salesi, W. He, S. Nakano, Y. Fujieda, S. Ooka, H. Oshima, D. Wang, W. Chen, R. O. Kaneko, H. Wei, A. Wanchu, Y. Hu, K. Okamoto, H. Kaneko, Y. Shinomura, M. Smiti-Khanfir, X. Liu, M. S. Aïfa, N. Nishimoto, T. M. Lin, S. Huang, J. H. Ju, H. Yamamoto, A. Nakajima, A. Boulila, H. de Jong, S. K. Kwok, E. Takahashi, M. Yamasaki, M. Rastin, W. Qin, B. Tsai, R. Nakashima, and N. Ishihara
Subjects: Pathology, medicine.medical_specialty, medicine.anatomical_structure, Human studies, business.industry, Immunology, medicine, Immunology and Allergy, Connective tissue, General Medicine, business
Published: 2010
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18. SLE and other connective tissue diseases (animal models) (PP-017)

Author: Robyn E. Mills, H. Kikutani, Y. Maeda, B. Wang, N. Kerekov, R. Minz, M. Rosemblatt, K. Tanaka, S. Hirose, A. I. Tchorbanov, B. Diamond, C. McPhee, A. Okamoto, K. Minowa, S. Ando, R. R. Singh, A. Espinosa, E. Yoshimoto, P. J. Kim, K. Y. Lee, H. S. Kim, S. K. Lee, M. Febbraio, V. Jeganathan, C. C. Tsai, P. A. Reyes, D. Roopenian, K. H. Lu, K. S. Midwood, T. Ishii, Y. Murakami, P. Gasse, R. Dardik, A. Ambrosi, Y. Akasaa, U. Minhas, I. Kamata, C. Esquivel, P. Wettstein, H. Murakami, A. Piccinini, M. Fridkin, F. Wermeling, S. M. Lind, L. Baraam, T. C. Hsu, K. Nikolova, P. Solanes, T. Kinoshita, A. Maeda, N. Okiyama, A. Tchorbanov, Y. Takasaki, D. Kawabata, L. Strandberg, A. Gleisner, B. S. Tzang, B. L. Chiang, V. Dzikaite, I. A. Udalova, F. G. Goh, K. Yamamoto, A. Francois, J. K. King, P. Chinnasamy, J. M. Oh, I. Couillin, Q. Zhou, Arthur Weiss, S. Morimoto, E. Peeva, M. Eisenstein, Y. Wang, D. Wachsmann, E. Y. Moon, T. Todorov, S. Shiozawa, W. Xu, E. Amano, C. Grimaldi, V. C. Lam, Michelle L. Hermiston, Nir Oksenberg, J. E. Gottenberg, T. Yasui, R. Srinivasan, K. Tsumiyama, A. Kalergis, J. Sibilia, M. Wahren-Herlenius, H. Amano, M. R. Bono, Mark S. Anderson, E. Katchalski-Katzir, A. Stanevsky, J. F. G. Cohen-Solal, Y. C. Chen, K. Fujio, Y. Heldman, E. Domange Jordö, N. Miyasaka, V. V. Gesheva, M. Nikolova, A. Bhatnagar, K. N. Fujita, T. Kuwabara, C. Dahlberg, T. Freedman, S. L. Cardell, S. Hirata, Y. Miyazaki, J. Bubier, H. Morse, Y. Shoenfeld, V. Gesheva, M. C. I. Karlsson, S. Xiong, T. Sproule, S. Izui, S. Y. Chen, M. Blank, H. Kohsaka, A. U. Eriksson, N. Mihaylova, and T. Sugihara
Subjects: Pathology, medicine.medical_specialty, medicine.anatomical_structure, business.industry, Immunology, Immunology and Allergy, Medicine, Connective tissue, General Medicine, business
Published: 2010
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19. Messenger ribonucleic acid expression profile in peripheral blood cells from RA patients following treatment with an anti-TNF-α monoclonal antibody, infliximab

Author: T. Abe, M. Ogasawara, K. Amano, S. Ito, N. Sekiguchi, T. Furuya, Tsutomu Takeuchi, N. Inaba, Koichi Matsuda, H. Aburatani, S. Ando, H. Kameda, and S. Kawauchi
Subjects: Adult, Male, Microarray, medicine.medical_treatment, Pharmacology, Severity of Illness Index, Arthritis, Rheumatoid, Rheumatology, medicine, Humans, Pharmacology (medical), RNA, Messenger, Aged, Oligonucleotide Array Sequence Analysis, Whole blood, biology, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha, business.industry, Gene Expression Profiling, C-reactive protein, Antibodies, Monoclonal, Middle Aged, Infliximab, TNF inhibitor, Gene expression profiling, C-Reactive Protein, Treatment Outcome, Cytokine, Gene Expression Regulation, Antirheumatic Agents, Immunology, biology.protein, Female, Tumor necrosis factor alpha, business, Biomarkers, medicine.drug
Abstract: Objectives. We monitored the mRNA expression profiles of peripheral blood cells during treatment with a TNF-� inhibitor, infliximab, in patients with RA. Using a DNA microarray analysis, we demonstrated a unique set of genes, with distinct baseline and post-treatment changes in expression between responders and non-responders to infliximab treatment. Methods. Using a customized low-density cDNA microarray with 747 genes and a reliable data collection system, we monitored the mRNA expression profiles of whole blood cells from 18 RA patients before and after the infusion of infliximab for up to 22 weeks. The clinical response to treatment with infliximab was determined using the ACR response criteria, the disease activity score of 28 joints (DAS28), and individual clinical parameters. The patients were classified as responders or non-responders based on their ACR50% response at 22 weeks. Results. Approximately 15% of the total genes were found to exhibit a >1.5-fold change, compared with their reference values, at one or more time points during the 22 weeks of infliximab therapy. The expression of inflammatory genes, such as IFN-related genes, was strongly correlated with the serum level of CRP and the DAS28. The increased expression of inflammatory genes in responders was normalized within 2 weeks and then remained at a normal level during the treatment period. In contrast, in the non-responders, the elevated expression at baseline, although it was significantly decreased at 2 weeks, returned to the baseline level after 14 weeks. In addition to inflammatory genes, we identified several groups of genes with distinct differences in expression between the responders and nonresponders. Conclusions. Our results suggest that a customized low-density microarray is useful for monitoring mRNA expression profiles in peripheral blood cells, enabling us to identify a unique set of genes with differentially regulated expressions in responders and non-responders to a TNF inhibitor among patients with RA.
Published: 2008
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20. Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages

Author: Dione Kawamoto, Ellen S. Ando-Suguimoto, Severino Matias de Alencar, Pedro Luiz Rosalen, Marcia Pinto Alves Mayer, and Bruno Bueno-Silva
Subjects: TIRAP, Lipopolysaccharides, Cell Survival, Macrophage polarization, Anti-Inflammatory Agents, lcsh:Medicine, Down-Regulation, Inflammation, Biology, Lymphocyte Activation, Nitric Oxide, Propolis, Cell Line, Mice, medicine, Animals, Viability assay, lcsh:Science, Multidisciplinary, Membrane Glycoproteins, Macrophages, lcsh:R, NF-kappa B, Receptors, Interleukin-1, NFKB1, Toll-Like Receptor 2, Cell biology, Up-Regulation, Toll-Like Receptor 4, TLR2, Cytokines, lcsh:Q, Tumor necrosis factor alpha, medicine.symptom, Signal transduction, Mitogen-Activated Protein Kinases, Transcriptome, Brazil, Signal Transduction, Research Article
Abstract: Although previous studies suggested an anti-inflammatory property of Brazilian red propolis (BRP), the mechanisms involved in the anti-inflammatory effects of BRP and its activity on macrophages were still not elucidated. This study aimed to evaluate whether BRP attenuates the inflammatory effect of LPS on macrophages and to investigate its underlying mechanisms. BRP was added to RAW 264.7 murine macrophages after activation with LPS. NO production, cell viability, cytokines profile were evaluated. Activation of inflammatory signaling pathways and macrophage polarization were determined by RT-qPCR and Western blot. BRP at 50 μg/ml inhibited NO production by 78% without affecting cell viability. Cd80 and Cd86 were upregulated whereas mrc1 was down regulated by BRP indicating macrophage polarization at M1. BRP attenuated the production of pro-inflammatory mediators IL-12, GM-CSF, IFN-Ɣ, IL-1β in cell supernatants although levels of TNF- α and IL-6 were slightly increased after BRP treatment. Levels of IL-4, IL-10 and TGF-β were also reduced by BRP. BRP significantly reduced the up-regulation promoted by LPS of transcription of genes in inflammatory signaling (Pdk1, Pak1, Nfkb1, Mtcp1, Gsk3b, Fos and Elk1) and of Il1β and Il1f9 (fold-change rate > 5), which were further confirmed by the inhibition of NF-κB and MAPK signaling pathways. Furthermore, the upstream adaptor MyD88 adaptor-like (Mal), also known as TIRAP, involved in TLR2 and TLR4 signaling, was down- regulated in BRP treated LPS-activated macrophages. Given that BRP inhibited multiple signaling pathways in macrophages involved in the inflammatory process activated by LPS, our data indicated that BRP is a noteworthy food-source for the discovery of new bioactive compounds and a potential candidate to attenuate exhacerbated inflammatory diseases.
Published: 2015

21. Polymorphisms inPTCH1Affect the Risk of Ameloblastoma

Author: Katsu Takahashi, Akira Shimizu, Shinji Kosugi, S. Ando, Tomohiro Kawabata, M. Nishida, Akiko Murashima-Suginami, Tadahiko Iizuka, Manabu Sugai, Ken-Ichiro Murakami, and Tosiya Sato
Subjects: Adult, Male, Patched Receptors, 0301 basic medicine, endocrine system, DNA Mutational Analysis, Dentistry, Receptors, Cell Surface, Tumor cells, Biology, Ameloblastoma, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Odds Ratio, medicine, Humans, Allele, General Dentistry, beta Catenin, Chi-Square Distribution, Polymorphism, Genetic, business.industry, Odontogenic tumor, 030206 dentistry, medicine.disease, Patched-1 Receptor, Cytoskeletal Proteins, 030104 developmental biology, PTCH1, Case-Control Studies, Trans-Activators, Cancer research, Female, Trinucleotide Repeat Expansion, business
Abstract: Ameloblastoma is the most common odontogenic tumor, but the genetic nature of the changes in the tumor cells has been unclear. Mutations of CTNNB1 or PTCH1 are observed in many human tumors. Both CTNNB1 and PTCH1 are important in tooth development and are expressed in ameloblastoma. The aim of this study was to investigate whether genetic alterations of CTNNB1 and PTCH1 are present in ameloblastoma. We investigated 14 cases of ameloblastoma. The polymorphisms found in the ameloblastoma patients were further examined in a subsequent case-control study. We found a CTNNB1 mutation in one case of plexiform-type ameloblastoma. CGG triplet repeat-number polymorphism (CGG7/CGG8) in the 5′-untranslated region of PTCH1 was observed. The proportion of CGG8 alleles was significantly higher in the ameloblastoma group. The results of this study indicate a possible relationship between the CGG8 allele in PTCH1 and the risk for ameloblastoma.
Published: 2005
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22. Salivary concentration of 5-hydroxytryptamine in patients with bulimia nervosa

Author: N. Takahashi, N. Kuronuma, N. Hamaue, T. Yoshihara, M. Senjo, S. H. Parvez, Toru Endo, Masaru Minami, Masahiko Hirafuji, and S. Ando
Subjects: Pharmacology, medicine.medical_specialty, Saliva, Bulimia nervosa, General Neuroscience, medicine.disease, Avoidant personality disorder, Eating disorders, Monoamine neurotransmitter, Mood, Endocrinology, Anorexia nervosa (differential diagnoses), Internal medicine, medicine, Psychology, Body mass index
Abstract: Patients with bulimia nervosa (BN) have disturbances of mood and behavior related to monoamine activities. There have been no reports concerning salivary concentrations of 5-hydroxytryptamine (5-HT) in patients with eating disorders such as anorexia nervosa (AN) and BN. In order to elucidate the involvement of 5-HT in eating disorders, 5-HT levels in the saliva of patients with BN were measured. Salivary 5-HT levels in patients with avoidant personality disorder (APD) were also measured as an active control. 5-HT levels in the saliva of patients with BN and APD were compared with those of 32 healthy volunteers. Simultaneously, salivary 3,4-dihydroxyphenylacetic acid (DOPAC) was measured using HPLC-ECD. 5-HT levels were 41.04 ± 14.41 in 11 patients with BN (10 women and 1 man, average age 19.6 years), 78.55 ± 45.55 in 5 patients with APD (3 women and 2 men, average age 19.2 years) and 8.91 ± 1.10 ng/ml in 32 healthy controls (25 women and 7 men, average age 21.7 years), respectively. This is the first report that salivary concentrations of 5-HT were significantly higher in BN (p < 0.05) and in APD than those in healthy controls. We found no significant differences among the salivary DOPAC levels in BN, APD and those of healthy controls. There were no significant differences in body mass index among the three groups. 5-HT concentrations in the saliva may be a useful marker of stress or eating disorders.
Published: 2004
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23. Estimation of Nutritive Value of Whole Crop Rice Silage and Its Effect on Milk Production Performance by Dairy Cows

Author: N. Yoshida, T. Nishida, S. Ando, M. Ishida, and Md. Rabiul Islam
Subjects: Silage, food and beverages, Biology, Milk production, Crop, Milk yield, medicine.anatomical_structure, Mature stage, Lactation, medicine, Animal Science and Zoology, Composition (visual arts), Food science, Feces, Food Science
Abstract: The nutritive value and utilization of whole crop rice silage (WCRS), Hamasari, at yellow mature stage was determined by three studies. In first study, chemical composition, in vivo digestibility and metabolizable energy (ME) content of WCRS was determined by Holstein steers. WCRS contains 6.23% CP, its digestibility is 48.4% and estimated TDN is 56.4%. Its ME content was 1.91 Mcal/kg DM. Gross energy (GE) retention (% of GE intake) in steers is only 22.7% most of which was lost through feces (44.7% of GE intake). It takes 81 minutes to chew a kg of WCRS by steers. In another study, the effect of Hamasari at yellow mature stage at three stages of lactation (early, mid and late lactation) and two levels of concentrate (40 or 60%) on voluntary intake, ME content and ME intake, milk yield and composition using lactating Holstein dairy cows were investigated. Total intake increased with the concentrate level in early and mid lactation, but was similar irrespective of concentrate level in late lactation. WCRS intake was higher with 40% concentrate level than with 60% concentrate. ME intake by cows increased with the concentrate level and WCRS in early lactating cows with 40% concentrate can support only 90% of the ME requirement. Milk production in accordance with ME intake increased with the increase in concentrate level in early and mid lactating cows but was similar in late lactating cows irrespective of concentrate level. Fat and protein percent of milk in mid and late lactating cows were higher with for 60% concentrate than 40%, but reverse was in early lactating cows. Solids-not-fat was higher with for 60% concentrate than 40% concentrate. Finally in situ degradability of botanical fractions such as leaf, stem, head and whole WCRS, Hamasari at yellow mature stage was incubated from 0 to 96 h in Holstein steers to determine DM and N degradability characteristics of botanical fractions and whole WCRS. Both DM and N solubility, rate of degradation and effective degradability of leaf of silage was lower, but slowly degradable fraction was higher compared to stem and head. Solubility of DM and N of stem was higher than other fractions. The 48 h degradability, effective degradability and rate of degradation of leaf were always lower than stem or head. In conclusion, voluntary intake of silage ranged from 5 to 12 kg/d and was higher with low levels of concentrate, but milk yield was higher with high levels of concentrate. Fat corrected milk yield ranged from 19 to 37 kg per day. For consistency of milk, early lactating cows should not be allowed more than 40% whole crop rice silage in the diet, but late lactating cows may be allowed 60% whole crop rice silage.
Published: 2004
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24. A novel methodology employing Corynebacterium glutamicum genome information to generate a new L -lysine-producing mutant

Author: Masato Ikeda, Junko Ohnishi, Satoshi Mitsuhashi, Haruhiko Yokoi, Mikiro Hayashi, Keiko Ochiai, and S. Ando
Subjects: Molecular Sequence Data, Mutant, Mutagenesis (molecular biology technique), Corynebacterium, Biology, medicine.disease_cause, Applied Microbiology and Biotechnology, Genome, Corynebacterium glutamicum, Industrial Microbiology, medicine, Homoserine Dehydrogenase, Aspartate Kinase, Gene, Pyruvate Carboxylase, Genetics, Homoserine dehydrogenase, Mutation, Lysine, Genomics, Sequence Analysis, DNA, General Medicine, Culture Media, Pyruvate carboxylase, Biochemistry, Fermentation, Genome, Bacterial, Biotechnology
Abstract: Classical whole-cell mutagenesis has achieved great success in development of many industrial fermentation strains, but has the serious disadvantage of accumulation of uncharacterized secondary mutations that are detrimental to their performance. In the post-genomic era, a novel methodology which avoids this drawback presents itself. This "genome-based strain reconstruction" involves identifying mutations by comparative genomic analysis, defining mutations beneficial for production, and assembling them in a single wild-type background. Described herein is an initial challenge involving reconstruction of classically derived L-lysine-producing Corynebacterium glutamicum. Comparative genomic analysis for the relevant terminal pathways, the efflux step, and the anaplerotic reactions between the wild-type and production strains identified a Val-59--Ala mutation in the homoserine dehydrogenase gene (hom), a Thr-311--Ile mutation in the aspartokinase gene (lysC), and a Pro-458--Ser mutation in the pyruvate carboxylase gene (pyc). Introduction of the hom and lysC mutations into the wild-type strain by allelic replacement resulted in accumulation of 8 g and 55 g of L-lysine/l, respectively, indicating that both these specific mutations are relevant to production. The two mutations were then reconstituted in the wild-type genome, which led to a synergistic effect on production (75 g/l). Further introduction of the pyc mutation resulted in an additional contribution and accumulation of 80 g/l after only 27 h. This high-speed fermentation achieved the highest productivity (3.0 g l(-1) h(-1)) so far reported for microbes producing L-lysine in fed-batch fermentation.
Published: 2002
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25. IgG sera levels against a subset of periodontopathogens and severity of disease in aggressive periodontitis patients: a cross-sectional study of selected pocket sites

Author: Giuseppe Alexandre Romito, Estela Sanches Rebeis, Marcia Pinto Alves Mayer, Ricardo Takiy Sekiguchi, Eder de S. Martins, Luciana Saraiva, Carlos Eduardo Secco Mafra, Marinella Holzhausen, and Ellen S. Ando-Suguimoto
Subjects: Serotype, Adult, Male, Alveolar Bone Loss, Serogroup, Aggregatibacter actinomycetemcomitans, Immunoglobulin G, law.invention, Young Adult, law, Gram-Negative Bacteria, Periodontal Attachment Loss, medicine, Aggressive periodontitis, Tannerella forsythia, Bacteroides, Humans, Periodontal Pocket, Porphyromonas gingivalis, Polymerase chain reaction, biology, biology.organism_classification, medicine.disease, Antibodies, Bacterial, Bacterial Load, Radiography, Cross-Sectional Studies, Aggressive Periodontitis, Immunology, Host-Pathogen Interactions, biology.protein, Periodontics, Female, Antibody
Abstract: Aims To evaluate the association among serum immunoglobulin G (IgG) responses to Aggregatibacter actinomycetemcomitans (Aa) serotypes a, b and c, Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf) and clinical parameters in Aggressive Periodontitis (AP) subjects. Associations between periodontal pathogens and clinical and immunological parameters were also evaluated. Methods Thirty-eight subjects diagnosed with generalized AP (GAP) and localized AP (LAP) were included. Ten healthy controls were also evaluated. Clinical parameters were assessed and percentages of subgingival levels of Aa, Pg and Tf (beyond bacterial load), were determined by quantitative real-time polymerase chain reaction. Serum IgG antibody levels against Aa, Pg and Tf were evaluated by enzyme-linked immunosorbent assay. Results Percentages of Aa, Pg and Tf were significantly higher in AP than in controls. The response to Aa serotype c was higher in LAP subjects than in controls. There were no differences in microbial composition or antibodies responses between GAP and LAP, except for IgG response to Tf. Pg levels were correlated with probing depth (PD), BoP and CAL in GAP but not in LAP subjects. Tf levels correlated with PD and CAL in GAP subjects. In GAP, the infection levels of Aa and Pg correlated with the corresponding IgG levels to Aa serotype c and Pg. Conclusion Given the evidences that IgG response in AP patients correlated with bacterial infection level in GAP, but not in LAP, and that LAP patients lack a response to Tf, despite harbouring this species, our data suggest a difference in host immune defence between these two forms of aggressive periodontitis.
Published: 2014

26. Establishment of a Simple Method for Measurement of Chronic Blood Flow in Uterine Artery of Pregnant Cows

Author: R. Islam, T. Nishida, Yoshikazu Nagao, S. Ando, and M. Ishida
Subjects: medicine.medical_specialty, Birth weight, Gestational Age, Biology, Xylazine, Animal science, Pregnancy, Internal medicine, medicine.artery, Genetics, medicine, Animals, Local anesthesia, Uterine artery, Fetus, Uterus, Uterine horns, Arteries, Blood flow, Endocrinology, Regional Blood Flow, Pregnancy, Animal, Gestation, Cattle, Female, Animal Science and Zoology, Blood Flow Velocity, Food Science, medicine.drug
Abstract: Blood flow to the gravid uterine horn of seven multiparous Holstein cows (mean +/- SD, BW = 625.5 +/- 82.4 kg; age = 4.7 +/- 1.7 yr; parity = 2.9 +/- 1.1 yr) was measured from d 225 of gestation to parturition using transit-time ultrasonic blood flow probes placed around the middle uterine artery. Surgery was conducted on d 215 of gestation. The cows were sedated with xylazine and local anesthesia (procaine or bupivacain hydrochloride) during surgery. The surgical operations were conducted at the flank of standing cows. A transit time ultrasonic flow probe ("S" series, diameter 12 or 14 mm, Transonic Systems Inc., Ithaca, NY) was fitted surgically around the uterine artery of each cow. Surgery was completed within 2 h of anesthesia, and the animals recovered rapidly following surgery. Uterine blood flow (UBF, L/min) was recorded at 10-s intervals for 1395 min; these values were averaged to determine UBF. Cows exhibited normal gestation lengths (279.1 +/- 7.4 d), gave birth to normal healthy calves (birth weight = 40.6 +/- 6.6 kg), and had no retained placentas. The UBF increased significantly (P0.01) from d 225 (6.67 +/- 2.47) to d 249 (8.23 +/- 2.89) of gestation, but the latter UBF was similar to that of d 266 (8.38 +/- 2.70). The increased UBF after d 225 indicates increased demand of nutrients of fetus with the progress of gestation. The range of mean UBF varied widely among individual cows from 4.1 L/min to 12.2 L/min. Our method is useful for chronic measurement of UBF in cows for nutritional or physiological studies and does not require sophisticated facilities or special surgical technique.
Published: 2001
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27. Effects of carbon ions on primary cultures of mouse brain cells

Author: Kumie Nojima, H. Fujiwara, S. Ando, and Koichi Ando
Subjects: Atmospheric Science, Aerospace Engineering, chemistry.chemical_element, Cell Count, Radiation Dosage, Flow cytometry, Ion, Mice, medicine, Animals, Heavy Ions, Linear Energy Transfer, Irradiation, Radiosensitivity, Cells, Cultured, Mice, Inbred C3H, medicine.diagnostic_test, Microglia, Brain, Dose-Response Relationship, Radiation, Astronomy and Astrophysics, Flow Cytometry, Immunohistochemistry, Molecular biology, Carbon, Specific antibody, Geophysics, medicine.anatomical_structure, Animals, Newborn, nervous system, chemistry, Space and Planetary Science, Astrocytes, General Earth and Planetary Sciences, Particle Accelerators
Abstract: Primary mixed cultures of astrocytes and microglia were obtained from neonatal mice, and were irradiated with high-LET carbon ions. Immunohistochemical staining showed astrocytes survived more prominently than microglia. Tagged with specific antibodies, astrocytes and microglia surviving after irradiation were counted by flow cytometry. Decreases in the number of microglia and astrocytes were detected at a dose as small as 2 Gy when Day 5 cultures were irradiated with 13 keV/micrometer carbon ions. When the cultures were irradiated on Day 10, the dose-dependent decrease of microglia was more prominent for 13 keV/micrometer carbon ions than 70 keV/micrometer carbon ions. Astrocytes showed a marginal decrease at Day 10 and Day 14. We concluded that microglia are more sensitive than astrocytes to carbon ions and X-rays, and that the radiosensitivity of microglia depends on both differentiation/proliferation status and radiation quality.
Published: 2000
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28. In VitroActivity of Garenoxacin againstChlamydiaspp

Author: T. Kishimoto, T. Yamazaki, M. Inoue, H. Hisada, S. Ando, and K. Sato
Subjects: Pharmacology, Chlamydia, business.industry, Microbial Sensitivity Tests, medicine.disease, In vitro, Garenoxacin, Anti-Bacterial Agents, Microbiology, chemistry.chemical_compound, Infectious Diseases, Oncology, chemistry, medicine, Pharmacology (medical), business, Fluoroquinolones
Published: 2008
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29. A method for determining the distribution of fluoride, calcium and phosphorus in human dental plaque and the effect of a single In vivo fluoride rinse

Author: K, Kato, H, Nakagaki, Y, Takami, S, Tsuge, S, Ando, and C, Robinson
Subjects: Saliva, Time Factors, Dental Plaque, Dentistry, chemistry.chemical_element, Calcium, Dental plaque, Specimen Handling, Fluorides, chemistry.chemical_compound, In vivo, medicine, Humans, Distribution (pharmacology), Fluorides, Topical, Dental Enamel, General Dentistry, Chromatography, Enamel paint, business.industry, Phosphorus, Cell Biology, General Medicine, medicine.disease, Otorhinolaryngology, chemistry, visual_art, visual_art.visual_art_medium, business, Fluoride
Abstract: A new sampling method, capable of sampling plaque from its surface to its interior for quantitative studies, was modified to meet some of the requirements for the determination of the fluoride and mineral (Ca and P) profiles within dental plaque formed in vivo. Plaque samples were repeatedly collected from the same individual, using special devices, before a single fluoride rinse (900 parts/10(6) fluoride) and 10 min and 24 hr after rinse. The method allowed examination of fluoride, calcium and phosphorus distribution along the entire thickness of plaque. Fluoride content significantly increased throughout the sample 10 min after rinsing, indicating the fluoride had rapidly penetrated into the plaque. Although the elevated fluoride concentrations diminished almost to baseline with 24 hr, a high correlation was found between fluoride and minerals in each plaque fraction. It is concluded that this technique will be useful for evaluating the fluoride and mineral behaviour in the saliva/plaque and plaque/enamel interfaces, and the anti caries efficacy of fluoride applications.
Published: 1997
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30. Impaired synaptic functions with aging as characterized by decreased calcium influx and acetylcholine release

Author: S. Ando, Y. Tanaka, and A. Hasegawa
Subjects: Aging, medicine.medical_specialty, Action Potentials, Decreased calcium, Nerve Tissue Proteins, Positive correlation, Synaptic Transmission, Choline O-Acetyltransferase, Potassium Chloride, Mice, Cellular and Molecular Neuroscience, Internal medicine, medicine, Animals, Aging brain, Cerebral Cortex, Voltage-dependent calcium channel, Chemistry, Biological Transport, Depolarization, Acetylcholine, Mice, Inbred C57BL, Endocrinology, Cholinergic Fibers, Calcium, Female, Choline acetyltransferase activity, Calcium Channels, Ion Channel Gating, Calcium influx, Synaptosomes, medicine.drug
Abstract: Age-related alterations of presynaptic functions were studied in terms of acetylcholine (ACh) synthesis and release using synaptosomes isolated from mouse brain cortices. The following three findings were obtained: (1) Choline acetyltransferase activity and ACh production rate remained constant throughout all ages tested. This observation, obtained with synaptosomes, was not consistent with data reported for brain slices (Gibson GE, Peterson C: J Neurochem 37:978–984, 1981). Various conditions, such as low glucose or membrane depolarization, modulated ACh synthesis to similar extents in young and aged synaptosomes. (2) Depolarization-induced release of ACh from synaptosomes significanty decreased in the senescent stage. The fraction of ACh released from aged synaptosomes was less than that released from young synaptosomes, although the ACh contents in the synaptosomes did not change with age. (3) Calcium influx induced by depolarization was lower in the synaptosomal preparations from aged mice than in those from young mice. A strong positive correlation was observed between the amounts of ACh released and the increased calcium levels when the data for all preparations, both from young and aged mice, were plotted. This indicates that diminished calcium influx may cause the reduced ACh release by aged synapses. The present study provides evidence for an age-related decrease in presynaptic functions, that is, a reduction in calcium influx via voltage-dependent calcium channels followed by a decreased ACh release from synapses despite an abundance of ACh within the synapses. © 1996 Wiley-Liss, Inc.
Published: 1996
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31. Antihypertensive and Metabolic Effects of Doxazosin in Hypertensive Patients with Concomitant Non-Insulin-Dependent Diabetes Mellitus

Author: S Matsumura, S Ando, Toshio Kaneko, Inoue M, M Hatao, Kohei Kaku, Yasushi Inoue, H Nakayama, and Y Yoshizaki
Subjects: Blood Glucose, Male, medicine.medical_specialty, medicine.medical_treatment, Blood Pressure, 030204 cardiovascular system & hematology, Carbohydrate metabolism, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Heart rate, Doxazosin, Humans, Medicine, Adrenergic alpha-Antagonists, Antihypertensive Agents, Aged, Glycated Hemoglobin, Chemotherapy, business.industry, Biochemistry (medical), Lipid metabolism, Cell Biology, General Medicine, Middle Aged, Lipid Metabolism, medicine.disease, Blood pressure, Endocrinology, Diabetes Mellitus, Type 2, 030220 oncology & carcinogenesis, Concomitant, Hypertension, Female, business, medicine.drug
Abstract: In this multicentre, non-randomized clinical study, 35 hypertensive patients with concomitant non-insulin-dependent diabetes mellitus were treated with the selective α1 adrenoceptor blocker doxazosin mesilate for 24 weeks, either alone or together with existing antihypertensive therapy. The effects of the drug on blood pressure, glucose and lipid metabolism were examined. Daily administration of 0.5 – 8 mg doxazosin caused a significant reduction in both systolic and diastolic blood pressure within 2 weeks. This effect was stable and lasted the entire trial period. The mean systolic and diastolic blood pressure decreased from 172 ± 15/90 ± 11 mmHg at the beginning, to 149 ± 19/80 ± 12 mmHg at the end of the trial. Heart rate was not affected. The plasma glucose level showed no change, whereas the haemoglobin A1c level decreased significantly from 7.4 ± 1.2% to 7.1 ± 1.2% ( P < 0.01). Total and high-density lipoprotein cholesterol levels remained unchanged. The triglycerides level, however, decreased from 113 ± 54 mg/dl at the beginning to 98 ± 49 mg/dl at the end of the trial ( P < 0.05). In a subgroup of patients, who showed hypercholesterolaemia (≥ 220 mg/dl, n = 9) at the beginning, the total cholesterol level decreased from 252 ± 33 mg/dl to 220 ± 33 mg/dl ( P < 0.05). Two patients complained of abdominal fullness or diarrhoea, but both were easily manageable. The results indicate that doxazosin is effective and safe in the treatment of hypertension in non-insulin-dependent diabetics and does not affect glucose metabolism. As for lipid metabolism in non-insulin-dependent diabetic patients, doxazosin seems to have a beneficial effect.
Published: 1996
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32. The effect of intravenous insulin infusion on pre- and post-meal plasma growth-hormone concentrations in calves

Author: S. Oshio, K. Hodate, A. Oshibe, and S. Ando
Subjects: Plasma growth hormone, medicine.medical_specialty, Meal, Endocrinology, Food Animals, business.industry, Internal medicine, Intravenous insulin, Medicine, Animal Science and Zoology, business, Pre and post
Abstract: Zusammenfassung Der Effekt einer intravenosen Insulininfusion auf die pra- umd postprandialen Konzentrationen an Wachstumshormon im Plasma beim Kalb Um den Effekt einer Insulininfusion auf die Konzentration von Wachtumshormon (GH) pra- und postprandial bei weiblichen japanischen schwarzen Kalbern zu untersuchen, erhielten die Tiere 10 mU bovines Insulin je kg Korpergewicht oder 10 mU/kgBW/h Insulin plus 75 mg/kgBW/h Glucose intravenos infundiert uber 5 Stunden vor der Futterung bis 5 Stunden nach der Futterung. Eine Kontrollgruppe erhielt auf die gleiche Weise Kochsalzlosung. Die Plasmakonzentrationen an Insulin, GH, Glucose und freien Fettsauren (FFA) wurden in 30 Min Abstanden von 6 Stunden vor bis 5 Stunden nach der Futterung gemessen. Die Insulininfusion fuhrte zu einer Erhohung (p < 0,05) des Plasmainsulin- und zu einer Erniedrigung der Glucose-Konzentration (p < 0,05). Bei der Infusion von Insulin plus Glucose war der Insulingehalt ebenfalls erhoht (p < 0,05), der Glucosegehalt lag so hoch wie in der Kontrollgruppe; nach der Infusion von Insulin und von Insulin plus Glucose lag die Insulinkonzentration praprandial unter 41,0 mU/ml Plasma, postprandial zwischen zwischen 51,9 und 151,8 mU/ml Plasma. Bei den FFS-Gehalten wurden keine Behandlungseffekte festgestellt. Die AUC vom Wachstumshormon lag postprandial niedriger (p < 0,05) als die praprandial bei Infusion von Insulin und Insulin plus Glucose gemessene. Zwischen den Infusions-Kalbern und den Kontrolltieren wurden keine Unterschiede beobachtet. Daraus last sich ableiten, das hohe Plasmainsulingehalte zu einer post-prandialen Depression der GH-Sekretion bei Kalbern fuhren.
Published: 1995
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33. The Long-Term Outcome of 154 Patients Receiving Balloon-Occluded Retrograde Trans-Venous Obliteration (B-RTO) for Gastric Fundal Varices

Author: K. Sugawara, Y. Imai, S. Mochida, M. Nakazawa, and S. Ando
Subjects: medicine.medical_specialty, Hepatology, business.industry, medicine, Balloon, Varices, business, Term (time), Surgery
Published: 2016
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34. Characteristics of carotenoid distribution in various tissues from red- and white-fleshed chinook salmon, Oncorhynchus tshawytscha (Walbaum)

Author: N. Fukuda, S. Ando, W. R. Heard, Y. Mori, and A. Sugawara
Subjects: chemistry.chemical_classification, endocrine system, Chinook wind, biology, organic chemicals, fungi, food and beverages, Zoology, Ovary, Aquatic Science, biology.organism_classification, White (mutation), Fishery, medicine.anatomical_structure, stomatognathic system, chemistry, medicine, Oncorhynchus, Integument, Carotenoid
Abstract: Carotenoid distribution was examined in muscle, ovary, integument and serum from red- and white-fleshed chinook salmon, Oncorhynchus tshawytscha (Walbaum), along with their muscle proximate compositions. There were no significant differences in muscle compositions of moisture, protein and lipid except for the carotenoid levels between red- and white-fleshed salmon. Similar carotenoid levels of ovaries were found between red- and white-fleshed chinook salmon, although the muscle carotenoid level of white-fleshed salmon was apparently low compared to red-fleshed salmon. This suggests that white-fleshed chinook salmon have the ability to accumulate the carotenoids in their ovaries but not muscle. The white-fleshed chinook salmon may be devoid of carotenoid receptors in their muscle and this seems to be the reason for the failure to accumulate the carotenoids in their muscle.
Published: 1994
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35. A multi-centre study of the efficacy and safety of pravastatin in hypercholesterolaemic patients with non-insulin-dependent diabetes mellitus

Author: Kohei Kaku, S Fujii, Toshio Kaneko, M Hatao, Masashi Okubo, S Ando, S Matsumura, Katsuhiro Hatao, and Yasushi Inoue
Subjects: Adult, Blood Glucose, Male, medicine.medical_specialty, Hypercholesterolemia, Gastroenterology, chemistry.chemical_compound, Internal medicine, Diabetes mellitus, medicine, Humans, Adverse effect, Aged, Pravastatin, Triglyceride, biology, Cholesterol, business.industry, General Medicine, Middle Aged, medicine.disease, Lipids, Hydroxymethylglutaryl-CoA reductase, Endocrinology, Diabetes Mellitus, Type 2, Tolerability, chemistry, HMG-CoA reductase, biology.protein, Female, lipids (amino acids, peptides, and proteins), business, medicine.drug
Abstract: A multi-centre, non-randomized clinical study of 12-months' duration was performed in 112 patients with hyperlipidaemia associated with non-insulin-dependent diabetes mellitus to evaluate the clinical efficacy and tolerability of pravastatin and to assess its effect on glycaemic control. Patients were eligible for this trial if they fulfilled the following criteria; a high plasma total cholesterol level greater than 220 mg/dl associated with stable glycaemic control for at least 3-months' observation period. On entry, patients received 10 mg pravastatin per day (5 mg twice daily) for 12 months. Clinical efficacy was evaluated in 108 patients. The results showed that pravastatin induced a significant decrease in serum cholesterol level mainly with LDL-cholesterol. Total cholesterol levels were decreased significantly from 275 +/- 3 mg/dl to 222 +/- 4 mg/dl within 3 months of the start of treatment, and LDL-cholesterol decreased from 192 +/- 4 mg/dl to 137 +/- 4 mg/dl. After 12 months' treatment, total cholesterol and LDL-cholesterol levels were 216 +/- 4 mg/dl (p < 0.001) and 137 +/- 5 mg/dl (p < 0.001), respectively. HDL-cholesterol levels were increased from 51 +/- 2 mg/dl to 56 +/- 2 mg/dl at 3 months (p < 0.001) and 55 +/- 2 mg/dl at 12 months (p < 0.01). Triglyceride concentrations were also decreased from 173 +/- 11 mg/dl to 156 +/- 13 mg/dl at 3 months and 137 +/- 10 mg/dl at 12 months (p < 0.01). Fasting plasma glucose and glycated haemoglobin levels were not affected by pravastatin. Adverse events observed in 5 cases were always mild and reversible. These results indicate a clinical usefulness of pravastatin with high compliance in patients with hyperlipidaemia associated with non-insulin-dependent diabetes mellitus.
Published: 1994
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36. Novel lacto-ganglio type gangliosides with GM2-epitope in bovine brain which react with IgM from a patient of the amyotrophic lateral sclerosis-like disorder

Author: Yu-Teh Li, Y. Hirabayashi, K. Kon, S. Ando, T. Miyatake, S. Furuya, N. Yuki, and Toru Nakao
Subjects: endocrine system, Ganglioside, biology, Chemistry, medicine.medical_treatment, Protein primary structure, Alpha (ethology), Cell Biology, Motor neuron, medicine.disease, Biochemistry, Molecular biology, Epitope, carbohydrates (lipids), medicine.anatomical_structure, Immunology, medicine, biology.protein, lipids (amino acids, peptides, and proteins), Plasmapheresis, Antibody, Amyotrophic lateral sclerosis, Molecular Biology
Abstract: A motor neuron disorder resembling that of amyotrophic lateral sclerosis was found in a patient who had received the intramuscular administration of a mixture of bovine brain gangliosides (Yuki, N., Sato, S., Miyatake, T., Sugiyama, K., Katagiri, T., and Sasaki, H. (1991) Lancet 337, 1109-1110). A very high titer of anti-GM2 IgM was detected in the patient's serum and the patient quickly recovered after plasmapheresis. The clinical course of the patient appeared to be different from amyotrophic lateral sclerosis and the anti-GM2 IgM was thought to be the culprit. The IgM reacted with GM2, GM1b-GalNAc, SPG(alpha 2-3)-GalNAc, and GD1a-GalNAc, but not with GA2 or GD2, meaning that the epitope recognized by the IgM was the GM2-like terminal structure, GalNAc beta 1-4(Neu-Ac alpha 2-3)Gal beta 1-. In this study, we found two novel GM2-epitope containing gangliosides, X1 and X2, in bovine brain gangliosides by TLC immunostaining using the patient's IgM. They were characterized as unique lacto-ganglio type gangliosides containing the following branching structures. [formula: see text] Their unusual structures may be immunogenic to humans to induce anti-GM2 antibody.
Published: 1993
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37. Relaxing Effect of Vesnarinone (OPC-8212) on the Tracheal Muscle Strips Isolated from Guinea Pigs

Author: K, Takeya, H, Ando, S, Ando, M, Yajima, and H, Nomura
Subjects: Male, medicine.medical_specialty, Reserpine, Thapsigargin, Carbachol, Guinea Pigs, chemistry.chemical_element, In Vitro Techniques, Calcium, chemistry.chemical_compound, 1-Methyl-3-isobutylxanthine, Internal medicine, medicine, Animals, Drug Interactions, Phenylephrine, Protein kinase C, Pharmacology, Activator (genetics), Airway Resistance, Isoproterenol, Propranolol, Trachea, Cytosol, Endocrinology, chemistry, Pyrazines, Ionomycin, Potassium, Quinolines, Female, Histamine, medicine.drug
Abstract: The effect of vesnarinone (OPC-8212), an orally active positive inotropic agent was studied in tracheal muscle isolated from guinea pigs, and the mechanism of its action was analyzed. Vesnarinone (10(-6)-10(-4) M) caused a concentration-dependent relaxation of tracheal muscle pre-contracted by 10(-4) M histamine. The potency of the relaxing effect of vesnarinone was greater than that of theophylline; the pD2 values for vesnarinone and theophylline were 4.9 and 4.5, respectively. Vesnarinone reduced the high-K(+)-induced contracture of depolarized tracheal muscle non-competitively (pD'2 = 3.7). Vesnarinone at the low concentration of 3 x 10(-6) M shifted the concentration-response curve for isoproterenol in a parallel fashion to the left. Vesnarinone additively acted on the relaxing effect of isobutyl methyl xanthine. Propranolol (10(-5) M) and reserpine pre-treatment (5 mg/kg, i.p., 24 hr) had no effect on the relaxing effect of vesnarinone. These results suggested that vesnarinone elevated the intracellular cyclic AMP level via phosphodiesterase inhibition, resulting in the tracheal muscle relaxation.
Published: 1993
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38. ChemInform Abstract: Synthesis and Evaluation of Water-Soluble Non-Prodrug Analogues of Docetaxel Bearing sec-Aminoethyl Group at the C-10 Position

Author: Kouichi Uoto, Haruhiro Takenoshita, Hirofumi Terasawa, Y. Hirota, Tsunehiko Soga, Ikuo Mitsui, S. Ando, and Toshiharu Yoshino
Subjects: Water soluble, Docetaxel, Chemistry, Stereochemistry, medicine, General Medicine, Prodrug, medicine.drug
Published: 2010
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39. Immune response to cytolethal distending toxin of Aggregatibacter actinomycetemcomitans in periodontitis patients

Author: Marcia Pinto Alves Mayer, Marcelo Faveri, E. S. Ando, L. A. De-Gennaro, M. Feres, and Joseph M. DiRienzo
Subjects: Adult, Cytolethal distending toxin, Adolescent, Cell Survival, Bacterial Toxins, Alveolar Bone Loss, Dental Plaque, Gingiva, CHO Cells, Aggregatibacter actinomycetemcomitans, Article, Microbiology, Young Adult, Immune system, Cricetulus, Neutralization Tests, Cricetinae, medicine, Aggressive periodontitis, Animals, Humans, Periodontal Pocket, Serotyping, Periodontitis, biology, MICROBIOLOGIA, Middle Aged, medicine.disease, biology.organism_classification, Chronic periodontitis, Antibodies, Bacterial, Immunity, Humoral, Protein Subunits, Aggressive Periodontitis, Immunoglobulin G, Immunology, Chronic Periodontitis, biology.protein, Periodontics, Antibody, Haemophilus ducreyi, Gingival Hemorrhage, Mutagens
Abstract: Aggregatibacter actinomycetemcomitans is a non-motile gram-negative facultative anaerobic coccobacillus associated with the etiology of aggressive periodontitis (1). The microorganism can also be detected in the oral cavity of chronic periodontitis patients and periodontally healthy subjects (2). A. actinomycetemcomitans is classified into six serotypes (a–f) based on surface O-polysaccharides, and serotype b is usually correlated with aggressive periodontitis (1), although other serotypes have been associated with diseased patients in certain populations (3,4). Similar to other mucosa-associated gram-negative pathogens, A. actinomycetemcomitans produces a cytolethal distending toxin (CDT; 5,6). Cytolethal distending toxin is a secreted tripartite AB2 toxin [An AB2 toxin is a toxin that has an active toxic subunit (A) represented by CdtB, and a B subunit which binds to the target cell, and is formed in Cdt by the subunits CdtA and CdtC], in which CdtB is the active toxic subunit that exhibits both type I deoxyribonuclease-like and phosphatase activities while subunits CdtA and CdtC seem to bind to target cells and CdtC also aids the delivery of CdtB into cells (6). The CDT triggers a DNA-damage response resulting in cell cycle arrest in G2/M or G0/G1 phase in many epithelial and macrophage cell lines and in T lymphocytes. Interestingly, CDT was not able to affect human periodontal ligament cells, although other fibroblastic cell lines were susceptible (6,7). Although the association of CDT with pathogenesis is not fully understood, this toxin may represent a bacterial adaptation which could affect the interaction between the bacterium and the host immune system in chronic diseases. Mice experimentally challenged with a CDT-deficient Helicobacter hepaticus mutant developed a significantly lower immunoglobulin (Ig)G2c response and failed to mount an IgG1 response (8). Cytolethal distending toxin can partly inhibit the production of proinflammatory cytokines by antigen-presenting cells, although A. actinomycetemcomitans CDT induced the production of interleukin (IL)-1β, IL-6, IL-8 and interferon-γ (IFN-γ) by human monocytes (9,10). In mice model, a Haemophilus ducreyi CDT-deficient mutant induced chancroid lesions similar to the wildtype strain (11). However, a Campylobacter jejuni CdtB-deficient mutant was less invasive in mouse tissues (12), leading to an attenuated inflammatory effect in the animal when compared with the wild-type (13). Furthermore, evidence suggested that the A. actinomycetemcomitans CDT inhibited nitric oxide (NO) production by murine macrophages (7). Very little is known about the humoral immune response to CDT in subjects colonized by producing bacteria. Similar levels of IgG to H. ducreyi CDT complex were observed in the sera of chancroid patients and control subjects, as well as in the sera of periodontitis subjects and control subjects (14). Even though the association between A. actinomycetemcomitans and localized aggressive periodontitis is well established, sera of few localized aggressive periodontitis patients contained antibodies to the A. actinomycetemcomitans CDT (15). We aimed to evaluate the association between the IgG response to A. actinomycetemcomitans serotypes and to CDT subunits in sera of subjects with different periodontal conditions. We also tested whether subgingival colonization by A. actinomycetemcomitans in generalized aggressive periodontitis subjects and induction of an antibody response against the organism would lead to an immune response to CDT subunits and to A. actinomycetemcomitans CDT neutralization by sera. The sera neutralization of localized aggressive periodontitis subjects against CDT activity was also tested.
Published: 2010

40. Measurement of serum IgE antibodies against Japanese cedar pollen ( Cryptomeria japonica ) in Japanese monkeys ( Macaca fuscata ) with pollinosis

Author: M. Sakaguchi, S. Inouye, K. Imaoka, H. Miyazawa, M. Hashimoto, H. Nigi, S. Nakamura, S. Gotoh, M. Minezawa, K. Fujimoto, S. Honjo, Y. Taniguchi, and S. Ando
Subjects: endocrine system, Allergy, General Veterinary, biology, Cryptomeria, biology.organism_classification, Immunoglobulin E, medicine.disease_cause, medicine.disease, Immune system, Allergen, Antigen, Pollen, Immunology, otorhinolaryngologic diseases, biology.protein, medicine, Animal Science and Zoology, Antibody
Abstract: IgE antibodies against allergens of Japanese cedar (Cryptomeria japonica, CJ) pollen in the serum of seven Japanese monkeys (Macaca fuscata) with pollinosis were measured by fluorometric indirect enzyme-linked immunosorbent assay (ELISA). All of the monkeys were found to have specific IgE to the crude pollen antigen. The specific IgE levels were well correlated with those determined by the Pharmacia CAP system. IgE antibodies were then assayed with two kinds of purified allergens (Cry j I and Cry j II) by the ELISA. We found that five monkeys had specific IgE to both allergens, although the other two had IgE only to Cry j I or Cry j II; there is different immune responsiveness to the two major allergens in the monkeys.
Published: 1992
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41. Human meconium gangliosides. Characterization of a novel I-type ganglioside with the NeuAc alpha 2-6Gal structure

Author: S Ando, Chiaki Rokukawa, K Kon, T Abe, Shizuo Handa, T. Kasama, and Takao Taki
Subjects: music.instrument, Ganglioside, Chemistry, medicine.drug_class, Alpha (ethology), Cell Biology, Fast atom bombardment, Monoclonal antibody, Biochemistry, Lactosylceramide, Glycolipid, Column chromatography, medicine, music, Beta (finance), Molecular Biology
Abstract: Three monosialogangliosides containing the NeuAc alpha 2-6Gal structure have been detected in human meconium by immunological analysis using a monoclonal antibody, MSG-15, and purified by repeated silica beads column chromatography. One was previously shown to be NeuAc alpha 2-6Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc beta 1-1Cer. The remaining two were characterized by proton NMR, fast atom bombardment mass spectrometry, methylation analysis by gas chromatography-mass spectrometry, and immunological studies, and their structures were concluded to be as follows. [formula: see text] The second ganglioside has the same structure that was isolated from bovine buttermilk (Takamizawa, K., Iwamori, M., Mutai, M., and Nagai, Y. (1986) J. Biol. Chem. 261, 5625-5630), and this is the first description of the occurrence of the ganglioside with the branched structure with two N-acetyllactosamines linked to lactosylceramide via beta 1-6 and beta 1-3 in human linked to lactosylceramide via beta 1-6 and beta 1-3 in human tissues. The third ganglioside is a novel ganglioside with blood group I-type and a NeuAc alpha 2-6Gal structure.
Published: 1992
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42. HB Yuoa orαl30(H13)ALA→ASP;: A New α Chain Variant with Low Oxygen Affinity

Author: K. Fujisawa, Yukio Hattori, S Ando, and Yuzo Ohba
Subjects: Mutation, Low oxygen, Stereochemistry, Biochemistry (medical), Clinical Biochemistry, Alpha (ethology), chemistry.chemical_element, Hematology, medicine.disease_cause, Oxygen, chemistry, medicine, Hemoglobin, Globin, Peptide sequence, Genetics (clinical), Alpha chain
Abstract: (1992). HB Yuoa or αl30(H13)ALA→ASP;: A New α Chain Variant with Low Oxygen Affinity. Hemoglobin: Vol. 16, No. 5, pp. 435-439.
Published: 1992
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43. Immunohistological study on brains of Alzheimer's disease using antibodies to fetal antigens, C-series gangliosides and microtubule-associated protein 5

Author: H. Takahashi, S. Ando, K. Hirokawa, and K. Obata
Subjects: Pathology, medicine.medical_specialty, Microtubule-associated protein, tau Proteins, Biology, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Fetus, Antigen, Alzheimer Disease, Gangliosides, Gene expression, medicine, Humans, Senile plaques, Antigens, Aged, Aged, 80 and over, Amyloid beta-Peptides, Antibodies, Monoclonal, Brain, Immunohistochemistry, Staining, medicine.anatomical_structure, Cerebral cortex, biology.protein, Neurology (clinical), Antibody, Microtubule-Associated Proteins, Immunostaining
Abstract: An immunohistological study of Alzheimer's brains was performed using antibodies to C-series gangliosides and microtubule-associated protein 5 (MAP5), and their staining patterns were compared with those of antibodies to tau and beta-amyloid precursor protein. Antibodies to C-series gangliosides and MAP5, both of which are known to preferentially expressed in the fetal brains, immunostained dystrophic neurites of senile plaques, neurofibrillary tangles and neuropil threads abundant in 3rd and 5th layers in the cerebral cortex, all of which are considered to be pathological hallmarks of Alzheimer's disease. The immunostaining patterns of these structures by antibodies to C-series gangliosides and MAP5 were similar to those by the antibody to tau. These three antibodies also immunostained some neurons in Alzheimer's brain, although their staining patterns were slightly different from one another; i.e., both diffuse and granular patterns were seen by the antibody to tau, but only granular pattern by the antibodies to C-series gangliosides and MAP5. These neurons immunostained by these three types of antibodies appeared to be the precursors of the classical neurofibrillary tangles, as positively stained neurons were not seen in the brains of non-demented cases. The presence of fetal antigens such as the C-series gangliosides and MAP5 in Alzheimer's brain may suggest that regeneration or sprouting of neurons is ongoing in association with the re-induction of gene expression characteristic for the brain in the early stage of development.
Published: 1991
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44. Structure of triphosphonoglycosphingolipid containing N-acetylgalactosamine 6-O-2-aminoethylphosphonate in the nervous system of Aplysia kurodai

Author: Mei Satake, S Ando, Sachiko Abe, K Kon, N Fujiwara, and S Araki
Subjects: Stereochemistry, Nervous tissue, Cell Biology, Nuclear magnetic resonance spectroscopy, Biochemistry, N-Acetylgalactosamine, Palmitic acid, chemistry.chemical_compound, Residue (chemistry), medicine.anatomical_structure, chemistry, Galactose, medicine, Side chain, Stearic acid, Molecular Biology
Abstract: A phosphonoglycosphingolipid, named F-21, was found in the nervous system of Aplysia kurodai by two-dimensional thin-layer chromatography (Abe, S., Araki, S., and Satake, M. (1986) Biomed. Res. (Tokyo) 7, 47-51). F-21 was isolated from the nervous tissue of Aplysia in this study, and its chemical structure was characterized as follows, where 2-AEP is 2-aminoethylphosphonate. (Formula; see text) The major aliphatic components of the ceramide portion were palmitic acid (75%), stearic acid (22%), octadeca-4-sphingenine (43%), and anteisononadeca-4-sphingenine (54%). Some information on the steric interactions in the sugar moiety was obtained by NMR spectroscopy. The ring protons of the internal galactose, H1, H3, and H4 and the H3 of the side chain galactose were shifted, as compared to the corresponding protons of dephosphonylated F-21. This may indicate the interactions between the 2-AEP residue of N-acetylgalactosamine and the internal galactose and between the N-acetyl group of N-acetylgalactosamine and the side chain galactose, implying a sterically restricted and unique structure that may relate to some biological functions of F-21.
Published: 1991
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45. The intracellular accumulation of phagocytic and epithelial cells and the inhibitory effect on Chlamydophila (Chlamydia) pneumoniae of telithromycin and comparator antimicrobials

Author: K. Sato, T. Kishimoto, M. Inoue, H. Takemura, M. Ogawa, S. Ando, and Tsutomu Yamazaki
Subjects: Ketolides, Telithromycin, Erythromycin, Minocycline, Microbial Sensitivity Tests, Biology, medicine.disease_cause, Microbiology, Cell Line, Ciprofloxacin, Clarithromycin, polycyclic compounds, medicine, Humans, Pharmacology (medical), Ketolide, Antibacterial agent, Pharmacology, Phagocytes, Dose-Response Relationship, Drug, organic chemicals, Epithelial Cells, biochemical phenomena, metabolism, and nutrition, Chlamydophila pneumoniae, Anti-Bacterial Agents, Infectious Diseases, Oncology, bacteria, Intracellular, medicine.drug
Abstract: The intracellular accumulation of telithromycin was measured and compared with ciprofloxacin, clarithromycin, minocycline and erythromycin. The activities of telithromycin, clarithromycin and minocycline against Chlamydophila (Chlamydia) pneumoniae were compared in an intracellular killing assay. Maximal telithromycin accumulation (mean intracellular/extracellular concentration ratio) ranged from 6.7 (A549 lung epithelial cells) to 11.8 (THP-1 monocytic cells). This ratio was similar to that of clarithromycin, but less than for minocycline. Minimum inhibitory and minimum lethal telithromycin concentrations against six clinical strains of C. pneumoniae were
Published: 2008

46. Resistance to thyroid hormone in a patient without thyroid hormone receptor mutations

Author: A. Schneider, S. Parikh, Paul M. Yen, S. Ando, Monica C. Skarulis, and Nicholas J. Sarlis
Subjects: Adult, Thyroid Hormone Resistance Syndrome, medicine.medical_specialty, Thyroid Hormones, Endocrinology, Diabetes and Metabolism, Thyrotropin-releasing hormone, Receptors, Cytoplasmic and Nuclear, Thyrotropin, Biology, medicine.disease_cause, Thyroid hormone receptor beta, Endocrinology, Internal medicine, Tachycardia, Weight Loss, medicine, Humans, RNA, Messenger, Receptor, Thyrotropin-Releasing Hormone, Fatigue, Intelligence Tests, Mutation, Thyroid hormone receptor, Triiodothyronine, Receptors, Thyroid Hormone, Goiter, Reverse Transcriptase Polymerase Chain Reaction, Thyroid, Thyroid Hormone Receptors beta, United States, DNA-Binding Proteins, medicine.anatomical_structure, National Institutes of Health (U.S.), Female, hormones, hormone substitutes, and hormone antagonists, Hormone
Abstract: Resistance to thyroid hormone (RTH) is a clinical syndrome characterized by elevated serum thyroid hormone (TH) levels, unsuppressed thyrotropin (TSH) levels, and tissue hyposensitivity to TH. In almost all cases, the genetic basis of RTH lies in mutation of one of the two TH receptor beta (TRbeta) alleles. Recently, patients from several families with phenotypic manifestations of RTH in the absence of TR mutations have been described. We report a case of a 31-year-old woman who presented with goiter, tachycardia, elevated TH levels, unsuppressed TSH, and "inappropriately normal" levels of peripheral TH action markers. In two separate clinical evaluations, the patient exhibited typical clinical and biochemical evidence for peripheral and pituitary RTH. Surprisingly, reverse transcriptase-polymerase chain reaction (RT-PCR) of full-length TRalpha and TRbeta mRNAs, and genomic PCR using primers flanking exons encoding the carboxy-terminal region of TRbeta failed to demonstrate mutations in the TRalpha or TRbeta genes. It is likely that defects in the regulation of TR genes or mutations in transcriptional cofactors involved in TR signaling account for this patient's phenotype.
Published: 2002

47. Induction of CD95 ligand expression on T lymphocytes and B lymphocytes and its contribution to apoptosis of CD95-up-regulated CD4+ T lymphocytes in macaques by infection with a pathogenic simian/human immunodeficiency virus

Author: Y. Suzaki, Kenji Someya, E. Takahashi, S. Ando, Tadashi Nakasone, Mitsuo Honda, Katsuaki Shinohara, Yasushi Ami, and Y. Sasaki
Subjects: CD4-Positive T-Lymphocytes, Fas Ligand Protein, T cell, Immunology, Apoptosis, HIV Infections, Biology, TCIRG1, Interleukin 21, hemic and lymphatic diseases, Lymphopenia, medicine, Immunology and Allergy, Cytotoxic T cell, Animals, IL-2 receptor, fas Receptor, Antigen-presenting cell, B-Lymphocytes, Membrane Glycoproteins, HIV, Immunity to Infection, T lymphocyte, Viral Load, Natural killer T cell, CD4 Lymphocyte Count, Up-Regulation, Macaca fascicularis, medicine.anatomical_structure, Leukocytes, Mononuclear, Simian Immunodeficiency Virus, Lymph Nodes
Abstract: SUMMARYUsing an established SIV/HIV-C2/1-infected cynomolgus monkey model displaying stable CD4+ T cell depletion, the kinetics of apoptosis and the levels of expression of CD95 membrane-associated CD95L on lymphocytes were investigated to test the involvement of the CD95/CD95L system in CD4+ T lymphocyte loss in vivo. Rapid depletion of CD4+ T cells occurred up to 2 weeks after infection, with chronic CD4+ T lymphopenia thereafter. During the initial CD4+ T cell loss, which was accompanied by viraemia, about 90% of the peripheral CD4+ T cell subset underwent spontaneous apoptotic cell death during 24 h of culture. Increased expression of CD95 was observed on both CD4+ and CD8+ T cell subsets, with CD95 expression on CD8+ cells declining rapidly, but high CD95 expression being maintained on CD4+ cells. Since CD95L was expressed on CD8+ T cells, B cells and to a lesser extent on CD4+ T cells, this suggests that CD95-mediated apoptosis might be controlled in an autocrine/paracrine fashion.
Published: 2000

48. Desmoglein1 and BP 180 ELISA indexes correlating with disease activity in a patient with coexisting pemphigus foliaceus and bullous pemphigoid

Author: M. Kasai, B. Ohyama, Daichi Hoshina, S. Ando, Ikue Nemoto-Hasebe, K. C. Sato-Matsumura, H. Shimuzu, and Takashi Hashimoto
Subjects: medicine.medical_specialty, biology, business.industry, Autoantibody, Dermatology, medicine.disease, Immunoglobulin G, Disease activity, Pemphigus, Desmoglein 1, biology.protein, Medicine, Bullous pemphigoid, business, Pemphigus foliaceus
Published: 2009
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49. Resting muscle sympathetic nerve activity and peak oxygen uptake in heart failure and normal subjects

Author: John S. Floras, S. Ando, C.F. Notarius, and Gerard A. Rongen
Subjects: Adult, Male, medicine.medical_specialty, Sympathetic nervous system, Sympathetic Nervous System, Heart disease, Exercise intolerance, Ventricular Dysfunction, Left, Oxygen Consumption, Internal medicine, Medicine, Humans, Muscle, Skeletal, Heart Failure, Ejection fraction, Exercise Tolerance, business.industry, VO2 max, Middle Aged, medicine.disease, Pathophysiology, Peripheral, Endocrinology, medicine.anatomical_structure, Heart failure, Exercise Test, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: Aims Exercise intolerance and increased eVerent vasoconstrictor traYc to muscle are two characteristics of heart failure that have not been explicitly linked. We tested the hypothesis that peak oxygen consumption is inversely related to resting muscle sympathetic nerve activity in heart failure. Methods and Results We recorded peroneal muscle sympathetic nerve activity in 17 treated heart failure patients (16 men,1 woman; mean ejection fraction of 26·0&3·2% (SE)) and 17 age-matched healthy subjects (16 men, 1 woman). Oxygen consumption was measured during cycle ergometry to maximal eVort. In heart failure and normal subjects, mean peak oxygen consumption was 20·6&1·7 vs 32·2&2·6 ml . kg "1 .m in "1 (P
Published: 1999

50. Calcium intake is weakly but consistently negatively associated with iron status in girls and women in six European countries

Author: Jadwiga Charzewska, A. Deloraine, S. Ando, L.P.L. van de Vijver, M. Rotily, J. Heikkinen, P. Charles, Kalervo Väänänen, G. Schaafsma, M. Maggiolini, Bożena Wajszczyk, A.F.M. Kardinaal, and Centraal Instituut voor Voedingsonderzoek TNO
Subjects: Transferrin Saturation Measurement, Aging, Girls, Medicine (miscellaneous), Transferrin saturation, Ascorbic Acid, Drug Interactions, Child, Human Nutrition & Health, chemistry.chemical_classification, Nutrition and Dietetics, medicine.diagnostic_test, biology, Humane Voeding & Gezondheid, Transferrin, Iron deficiency, Normal human, Europe, Chemistry, Biochemistry, Human experiment, Iron absorption, Serum iron, Female, Dietary Proteins, Dietary calcium, Iron blood level, Regression analysis, Iron, Dietary, Cross- sectional, Human, Adult, medicine.medical_specialty, Adolescent, Iron, chemistry.chemical_element, Nutritional Status, Calcium, Calcium intake, Internal medicine, medicine, Humans, Women, VLAG, Nutrition, Ferritin, Iron status, Dietary intake, Body Weight, Ascorbic acid, medicine.disease, Body Height, Calcium, Dietary, Endocrinology, chemistry, Ferritins, biology.protein, School child, Energy Intake
Abstract: Several studies indicate that intake of calcium can inhibit iron absorption especially when taken simultaneously. In the CALEUR study, a cross-sectional study among girls (mean 13.5 y) and young women (mean 22.0 y) in six European countries, the association between calcium intake and iron status was studied. In 1,080 girls and 524 women, detailed information on calcium intake was collected by means of a 3-d food record, and serum ferritin, serum iron, serum transferrin and transferrin saturation were measured as indicators of iron status. The mean levels of serum iron, ferritin and transferrin were 15.8 ± 6.1 mmol/L, 34.5 ± 19.1 μg/L and 3.47 ± 0.47 g/L, respectively, in girls and 16.9 ± 7.5 mmol/L, 40.2 ± 30.5 and μg/L, 3.59 ± 0.60 g/L, respectively, in women. A consistent inverse association between calcium intake and serum ferritin was found, after adjusting the linear regression model for iron intake, age, menarche, protein, tea and vitamin C intake and country, irrespective of whether calcium was ingested simultaneously with iron. The adjusted overall regression coefficients for girls and women were -0.57 ± 0.20 and -1.36 ± 0.46 per 100 mg/d increase in calcium intake, respectively. Only in girls, transferrin saturation as a measure for short-term iron status was inversely associated with calcium intake (adjusted overall coefficient -0.18 ± 0.08). However, analysis per country separately showed no consistency. We conclude that dietary calcium intake is weakly inversely associated with blood iron status, irrespective of whether calcium was ingested simultaneously with iron.Chemicals/CAS: Ascorbic Acid, 50-81-7; Calcium, Dietary; Dietary Proteins; Ferritins, 9007-73-2; Iron, 7439-89-6; Iron, Dietary; Transferrin, 11096-37-0
Published: 1999

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