282 results on '"S, Ikeda"'
Search Results
2. Genome- and transcriptome-wide splicing associations with alcohol use disorder
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Spencer B. Huggett, Ami S. Ikeda, Qingyue Yuan, Chelsie E. Benca-Bachman, and Rohan H. C. Palmer
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Medicine ,Science - Abstract
Abstract Genetic mechanisms of alternative mRNA splicing have been shown in the brain for a variety of neuropsychiatric traits, but not substance use disorders. Our study utilized RNA-sequencing data on alcohol use disorder (AUD) in four brain regions (n = 56; ages 40–73; 100% ‘Caucasian’; PFC, NAc, BLA and CEA) and genome-wide association data on AUD (n = 435,563, ages 22–90; 100% European-American). Polygenic scores of AUD were associated with AUD-related alternative mRNA splicing in the brain. We identified 714 differentially spliced genes between AUD vs controls, which included both putative addiction genes and novel gene targets. We found 6463 splicing quantitative trait loci (sQTLs) that linked to the AUD differentially spliced genes. sQTLs were enriched in loose chromatin genomic regions and downstream gene targets. Additionally, the heritability of AUD was enriched for DNA variants in and around differentially spliced genes associated with AUD. Our study also performed splicing transcriptome-wide association studies (TWASs) of AUD and other drug use traits that unveiled specific genes for follow-up and splicing correlations across SUDs. Finally, we showed that differentially spliced genes between AUD vs control were also associated with primate models of chronic alcohol consumption in similar brain regions. Our study found substantial genetic contributions of alternative mRNA splicing in AUD. more...
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- 2023
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3. Magnetic resonance–guided laser interstitial thermal therapy for pediatric periventricular nodular heterotopia-related epilepsy
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Lucia Ruggieri, Daniel S. Ikeda, Sungho Lee, Vijay M. Ravindra, Ilana Patino, Daniel J. Curry, and David D. Gonda
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Magnetic resonance imaging ,General Medicine ,Ventricular system ,medicine.disease ,Ablation ,Stereoelectroencephalography ,Epilepsy ,Refractory ,Laser Interstitial Thermal Therapy ,medicine ,Radiology ,business ,Electrocorticography - Abstract
OBJECTIVE Periventricular nodular heterotopia (PVNH) is a result of disrupted neuronal migration from the ventricular system and can be a rare cause of refractory focal epilepsy. The goal of this case series was to describe the treatment of pediatric PVNH-related epilepsy with MR-guided laser interstitial thermal ablation. METHODS Patients treated at a single institution with MR-guided laser interstitial thermal therapy (MRgLITT) for PVNH-related epilepsy were identified. Preoperative and postoperative seizure outcomes and procedural information were evaluated. RESULTS Five children with PVNH treated with MRgLITT were reviewed; 1 child was treated twice. Three patients were female; the median age was 10.9 years. Five of 6 treatments were preceded by stereoelectroencephalography phase II monitoring. Three children experienced unilateral PVNH, and 2 had bilateral seizures. The median number of seizures recorded during phase II monitoring was 2; the median number of ablation targets was 2 (range 1–4). All patients experienced a decrease in seizure frequency; 4 patients (80%) had an Engel class ≤ III at the last follow-up (range I–IV). One child experienced right hemianopia posttreatment. CONCLUSIONS This case series investigation has illustrated a novel, minimally invasive approach for treating pediatric PVNH-related epilepsy. Further study of this technique with comparison with other surgical techniques is warranted. more...
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- 2021
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4. Gastrointestinal stromal tumour lacking mutations in the <scp> KIT </scp> and <scp> PDGFRA </scp> genes in a cat
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Y Fujii, Hiroki Sakai, S Chimura, Ryota Iwasaki, N Ito, K Yoshizaki, Takashi Mori, S Ikeda, and M Goto
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CATS ,Stromal cell ,business.industry ,Growth factor ,medicine.medical_treatment ,PDGFRA ,Gastrointestinal stromal tumours ,Mutational analysis ,Cancer research ,medicine ,Small Animals ,business ,Gene ,Tyrosine kinase - Abstract
Molecular subtyping in gastrointestinal stromal tumours is a useful method for predicting the efficacy of treatment using tyrosine kinase inhibitors in humans. However, owing to the paucity of reports on mutational analyses, the association between genetic mutations and the therapeutic response to tyrosine kinase inhibitors remains unclear in feline gastrointestinal stromal tumours. In this report, we describe the case of a cat with a gastrointestinal stromal tumour which was unresponsive to tyrosine kinase inhibitors. A mutational analysis revealed that the cat lacked mutations in both the KIT and platelet-derived growth factor receptor-alpha (PDGFRA) genes. Our findings are consistent with the fact that KIT/PDGFRA wild-type gastrointestinal stromal tumours are less responsive to tyrosine kinase inhibitors in humans. This signifies the need for further evaluation and possibly individualised treatment for gastrointestinal stromal tumours in cats on the basis of mutational analyses. more...
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- 2021
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5. Paradoxical Contralateral Herniation Detected by Pupillometry in Acute Syndrome of the Trephined
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Victoria E. Fischer, Jason H Boulter, Daniel S. Ikeda, and Randy S. Bell
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medicine.medical_specialty ,Intracranial Pressure ,Traumatic brain injury ,Decompression ,Computed tomography ,03 medical and health sciences ,0302 clinical medicine ,Brain Injuries, Traumatic ,medicine ,Medical imaging ,Humans ,Intracranial pressure ,medicine.diagnostic_test ,business.industry ,Skull ,Public Health, Environmental and Occupational Health ,030208 emergency & critical care medicine ,General Medicine ,medicine.disease ,Decompressive Craniectomies ,Intracranial pressure monitoring ,Radiology ,Tomography, X-Ray Computed ,business ,Craniotomy ,030217 neurology & neurosurgery ,Pupillometry - Abstract
Severe traumatic brain injury has historically been a non-survivable injury. Recent advances in neurosurgical care, however, have demonstrated that these patients not only can survive, but they also can recover functionally when they undergo appropriate cerebral decompression within hours of injury. At the present, general surgeons are deployed further forward than neurosurgeons (Role 2 compared to Role 3) and have been provided with guidelines that stipulate conditions where they may have to perform decompressive craniectomies. Unfortunately, Role 2 medical facilities do not have access to computed tomography imaging or intracranial pressure monitoring capabilities rendering the decision to proceed with craniectomy based solely on exam findings. Utilizing a case transferred from downrange to our institution, we demonstrate the utility of a small, highly portable quantitative pupillometer to obtain reliable and reproducible data about a patient’s intracranial pressures. Following the case presentation, the literature supporting quantitative pupillometry for surgical decision-making is reviewed. more...
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- 2020
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6. Bow hunter syndrome in rheumatoid arthritis: illustrative case
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Vijay M Ravindra, Brian P Curry, Jason H Boulter, Chris J. Neal, and Daniel S. Ikeda
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medicine.medical_specialty ,business.industry ,Rheumatoid arthritis ,Medicine ,Hunter syndrome ,General Medicine ,business ,medicine.disease ,Dermatology - Abstract
BACKGROUND Rheumatoid arthritis (RA) frequently features degeneration and instability of the cervical spine. Rarely, this degeneration manifests as symptoms of bow hunter syndrome (BHS), a dynamic cause of vertebrobasilar insufficiency. OBSERVATIONS The authors reviewed the literature for cases of RA associated with BHS and present a case of a man with erosive RA with intermittent syncopal episodes attributable to BHS as a result of severe extrinsic left atlantooccipital vertebral artery compression from RA-associated cranial settling. A 72-year-old man with RA-associated cervical spine disease who experienced gradual, progressive functional decline was referred to a neurosurgery clinic for evaluation. He also experienced intermittent syncopal events and vertiginous symptoms with position changes and head turning. Vascular imaging demonstrated severe left vertebral artery compression between the posterior arch of C1 and the occiput as a result of RA-associated cranial settling. He underwent left C1 hemilaminectomy and C1–4 posterior cervical fusion with subsequent resolution of his syncope and vertiginous symptoms. LESSONS This is an unusual case of BHS caused by cranial settling as a result of RA. RA-associated cervical spine disease may rarely present as symptoms of vascular insufficiency. Clinicians should consider the possibility, though rare, of cervical spine involvement in patients with RA experiencing symptoms consistent with vertebral basilar insufficiency. more...
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- 2021
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7. Perforated Appendicitis: An Unintended Consequence During the Coronavirus-19 Pandemic
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Paul R. Lewis, Emily M Benzer, Andrew W. Wang, James M. Prieto, Daniel S. Ikeda, and Jan-Michael Van Gent
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Adult ,Male ,medicine.medical_specialty ,Delayed Diagnosis ,Perforation (oil well) ,030204 cardiovascular system & hematology ,Feature Article and Original Research ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Pandemic ,medicine ,Appendectomy ,Humans ,030212 general & internal medicine ,Pandemics ,Retrospective Studies ,SARS-CoV-2 ,business.industry ,Incidence ,Incidence (epidemiology) ,Public Health, Environmental and Occupational Health ,COVID-19 ,Retrospective cohort study ,Fear ,General Medicine ,Length of Stay ,Middle Aged ,Appendicitis ,medicine.disease ,Quarantine ,Emergency medicine ,Cohort ,Female ,AcademicSubjects/MED00010 ,Emergency Service, Hospital ,business ,Historical Cohort ,Cohort study - Abstract
Background The coronavirus disease 2019 (COVID-19) pandemic has had major clinical impact across the globe. Delayed presentation for medical emergencies has been noted by the medical community. There has been limited reporting on the impact for the care for emergent surgical conditions. We sought to describe the effect of the global pandemic on the presentation and outcomes for the most common urgent general surgery disease process, acute appendicitis. Methods We performed a retrospective review of patients admitted to the United States Naval Hospital Okinawa during the COVID-19 pandemic, from January 2020 to May 2020 (COVID cohort), and compared them to a historical cohort (pre-COVID cohort) over the prior 2 years. Demographics, clinical presentation data, and interventions were collected. Results Of the 80 patients with appendicitis, 20% presented perforated. Most patients were male (71%), presented with 1 day of symptoms and had a length of stay of 1 to 2 days. Comparing groups, 13% of the pre-COVID group vs. 31% of the COVID cohort presented perforated (P = .04), with a symptom duration of 1.6 vs. 2.7 days before presentation (P = .075), respectively. Conclusions The COVID-19 pandemic and the global systematic response has impacted unrelated medical and surgical conditions. At our overseas military hospital with minimal disease burden, we observed a delay in presentation for acute appendicitis with a higher incidence of perforation. Patients should be empowered to continue to seek care for urgent and emergent medical and surgical conditions so that they are not harmed by fear of COVID-19 rather than by COVID-19 itself. more...
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- 2021
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8. Biographies of international women leaders in neurosurgery
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Anisha Venkatesh, Teresa Scott, E. Antonio Chiocca, Lauren G. Culver, Nitin Agarwal, Paul N. Porensky, Evan S. Marlin, Ahmad Ozair, Laura B. Ngwenya, Nallammai Muthiah, Eva M. Wu, Rossana Romani, Tracy E. Sutton, Ankur Bajaj, Elizabeth E. Ginalis, Katherine Berry, Neena I. Marupudi, Steven D. Ham, Russell R. Lonser, Abhinav Arun Sonkar, Arjumand Faruqi, Vivek Bhat, John M. McGregor, Gary L. Rea, David Dornbos, Victoria A. Schunemann, Andrew Shaw, Ciaran J. Powers, Stephanie M. Casillo, Daniel S. Ikeda, Ammar Shaikhouni, Dhananjaya I Bhat, Kristin Huntoon, Alyssa M. Goodwin, Laura Fernandez, Jacob Gluski, Sarita Aristizabal, and Michael Wang more...
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Service (business) ,medicine.medical_specialty ,Neurosurgery ,Gender studies ,Biography ,General Medicine ,Neurocirugía ,Neurosurgical Procedures ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Chose ,0302 clinical medicine ,International ,medicine ,Humans ,Female ,Surgery ,Women ,Neurology (clinical) ,Psychology ,030217 neurology & neurosurgery - Abstract
We received so many biographies of women neurosurgery leaders for this issue that only a selection could be condensed here. In all of them, the essence of a leader shines through. Many are included as “first” of their country or color or other achievement. All of them are included as outstanding—in clinical, academic, and organized neurosurgery. Two defining features are tenacity and service. When faced with shocking discrimination, or numbing indifference, they ignored it or fought valiantly. When choosing their life’s work, they chose service, often of the most neglected—those with pain, trauma, and disability. These women inspire and point the way to a time when the term “women leaders” as an exception is unnecessary.—Katharine J. Drummond, MD, on behalf of this month’s topic editors more...
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- 2021
9. When upper respiratory tract infections go rogue: A case report of Arcanobacterium haemolyticum Cerebral Abscess
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Ryan Leverette, Nehkonti Adams, Daniel S. Ikeda, Christopher Snitchler, Anthony Skinner, Juan Rodriguezbarrantes, Michael Kong, and Randy S. Bell
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medicine.medical_specialty ,Preseptal cellulitis ,Case Report ,Infectious and parasitic diseases ,RC109-216 ,Arcanobacterium haemolyticum ,medicine ,Sinusitis ,Abscess ,Sinus (anatomy) ,Respiratory tract infections ,medicine.diagnostic_test ,biology ,business.industry ,Magnetic resonance imaging ,medicine.disease ,biology.organism_classification ,Pharyngitis ,Surgery ,Infectious Diseases ,medicine.anatomical_structure ,Cellulitis ,Cerebral abscess ,medicine.symptom ,business - Abstract
Arcanobacterium haemolyticum is an extremely rare cause of cerebral abscess. We present a unique case of Arcanobacterium haemolyticum sinusitis complicated by preseptal cellulitis and cerebral abscess. The patient initially presented with pharyngitis and then developed sinus congestion, headache and facial pain. Computed tomography and magnetic resonance imaging revealed a right gyrus rectus cerebral abscess and paranasal sinus infection. The patient underwent endoscopic sinus surgery and cultures revealed Arcanobacterium haemolyticum. Repeat imaging revealed maturation and progression of intracranial abscess. The abscess was drained and patient was treated with parenteral and oral antibiotics until complete clinical and radiological remission. This case highlights the importance of recognizing Arcanobacterium haemolyticum as a cause of invasive disease in immunocompetent hosts. more...
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- 2021
10. U.S. Neurosurgical Response to COVID-19: Forging a Path Toward Disaster Preparedness
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Shawn Belverud, Gavin P. Dunn, Jonathon Cooke, Jonathan Gilhooly, Vijay M Ravindra, Paul Porenksy, Jeffrey M. Tomlin, Scott L. Zuckerman, Christopher P. Carroll, Daniel S. Ikeda, Arnett Klugh, David Malone, Richard Menger, and Randy S. Bell more...
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Active duty ,Coronavirus disease 2019 (COVID-19) ,Feature Article and Original Research ,Disasters ,03 medical and health sciences ,0302 clinical medicine ,Political science ,Health care ,Pandemic ,medicine ,Humans ,030212 general & internal medicine ,Pandemics ,business.industry ,SARS-CoV-2 ,Public Health, Environmental and Occupational Health ,COVID-19 ,General Medicine ,medicine.disease ,On board ,Navy ,Neurosurgeons ,Software deployment ,Disaster preparedness ,Medical emergency ,business ,AcademicSubjects/MED00010 ,030217 neurology & neurosurgery - Abstract
Introduction The worldwide COVID-19 pandemic poses challenges to healthcare capacity and infrastructure. The authors discuss the structure and efficacy of the U.S. Navy’s response to COVID-19 and evaluate the utility of this endeavor, with the objective of providing future recommendations for managing worldwide healthcare and medical operational demands from the perspective of Navy Neurosurgery. Materials and Methods The authors present an extensive review of topics and objectively highlight the efforts of U.S. Navy Neurosurgery as it pertains to the humanitarian mission during the COVID-19 pandemic. Results During the humanitarian mission (March 27, 2020–April 14, 2020), the response of active duty and reserve neurosurgeons in the U.S. Navy was robust. Neurosurgical coverage was present on board the U.S. Navy Ships Mercy and Comfort, with additional neurosurgical deployment to New York City for intensive care unit management and coverage. Conclusions The U.S. Navy neurosurgical response to the COVID-19 pandemic was swift and altruistic. Although neurosurgical pathologies were limited among the presenting patients, readiness and manpower continue to be strong influences within the Armed Forces. The COVID-19 response demonstrates that neurosurgical assets can be rapidly mobilized and deployed in support of wartime, domestic, and global humanitarian crises to augment both trauma and critical care capabilities. more...
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- 2020
11. Usefulness of an artificial neural network for a beginner to achieve similar interpretations to an expert when examining myocardial perfusion images
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Minoru Morikawa, Y Koide, Seiji Koga, Tsuyoshi Yonekura, Reiko Ideguchi, Hiroaki Kawano, Masataka Uetani, Akira Tsuneto, S Ikeda, K Maemura, Akiyo Chiba, Takashi Kudo, and M Altay
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Artificial neural network ,Artificial intelligence ,medicine.medical_specialty ,Ischemia ,Myocardial perfusion imaging ,Predictive Value of Tests ,Internal medicine ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Cardiac imaging ,Cardiology imaging ,Tomography, Emission-Computed, Single-Photon ,Original Paper ,medicine.diagnostic_test ,business.industry ,Myocardial perfusion images ,Myocardial Perfusion Imaging ,Heart ,Blood flow ,equipment and supplies ,medicine.disease ,Perfusion ,body regions ,SSS ,Nuclear medicine ,Cardiology ,Neural Networks, Computer ,Cardiology and Cardiovascular Medicine ,business - Abstract
This study examined whether using an artificial neural network (ANN) helps beginners in diagnostic cardiac imaging to achieve similar results to experts when interpreting stress myocardial perfusion imaging (MPI). One hundred and thirty-eight patients underwent stress MPI with Tc-labeled agents. An expert and a beginner interpreted stress/rest MPI with or without the ANN and the results were compared. The myocardium was divided into 5 regions (the apex; septum; anterior; lateral, and inferior regions), and the defect score of myocardial blood flow was evaluated from 0 to 4, and SSS, SRS, and SDS were calculated. The ANN effect, defined as the difference in each of these scores between with and without the ANN, was calculated to investigate the influence of ANN on the interpreters' performance. We classified 2 groups (insignificant perfusion group and significant perfusion group) and compared them. In the same way, classified 2 groups (insignificant ischemia group and significant ischemia group) and compared them. Besides, we classified 2 groups (normal vessels group and multi-vessels group) and compared them. The ANN effect was smaller for the expert than for the beginner. Besides, the ANN effect for insignificant perfusion group, insignificant ischemia group and multi-vessels group were smaller for the expert than for the beginner. On the other hand, the ANN effect for significant perfusion group, significant ischemia group and normal vessels group were no significant. When interpreting MPI, beginners may achieve similar results to experts by using an ANN. Thus, interpreting MPI with ANN may be useful for beginners. Furthermore, when beginners interpret insignificant perfusion group, insignificant ischemia group and multi-vessel group, beginners may achieve similar results to experts by using an ANN. more...
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- 2020
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12. Transpacific Aeromedical Evacuation for a Ruptured Brain Arteriovenous Malformation During the COVID-19 Pandemic
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Jan-Michael Van Gent, Emily M Benzer, Vijay M Ravindra, Daniel S. Ikeda, Steven P. Praske, John R Dryden, Brian P Curry, Randy S. Bell, and Charles A Miller
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Referral ,MEDLINE ,Case Report ,Military medicine ,Arteriovenous Malformations ,03 medical and health sciences ,0302 clinical medicine ,Pandemic ,medicine ,Humans ,030212 general & internal medicine ,Pandemics ,Intracerebral hemorrhage ,business.industry ,SARS-CoV-2 ,Public Health, Environmental and Occupational Health ,Brain ,COVID-19 ,Arteriovenous malformation ,General Medicine ,Air Ambulances ,medicine.disease ,Military personnel ,Emergency evacuation ,Medical emergency ,business ,AcademicSubjects/MED00010 ,030217 neurology & neurosurgery - Abstract
The COVID-19 pandemic has altered preexisting patient treatment algorithms and referral patterns, which has affected neurosurgical care worldwide. Brain arteriovenous malformations are complex vascular lesions that frequently present with intracerebral hemorrhage. Care for these patients is best performed at large medical centers by specialists with high volumes. The authors describe the care of a patient who presented in extremis to a resource-limited, community-sized military treatment facility (MTF) in Southeast Asia. In the MTF, the patient underwent emergent neurosurgical therapy. However, given newly implemented restrictions enacted to mitigate COVID-19 spread, local transfer for definitive care to a tertiary care facility was not possible. In order to attain definitive care for the patient, a transpacific aeromedical evacuation augmented with a critical care air transport team was utilized for transfer to a tertiary care, teaching hospital. This case demonstrates the safe treatment of a patient with hemorrhagic arteriovenous malformations and postoperative management under limited conditions in an MTF outside the CONUS. Given the unique circumstances and challenges the pandemic presented, the authors feel that this patient’s outcome was only possible by leveraging all the capability military medicine has to offer. more...
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- 2020
13. Identification of Predictive Biomarkers for Immunotherapy with Immune Checkpoint Inhibitors in Patients with Advanced Non-Small Cell Lung Cancer
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Kohei Somekawa, S. Ikeda, Hiromi Kanaoka, Nobuaki Kobayashi, Ryota Ushio, Nobuyuki Hirama, T. Muraoka, Chisato Kamimaki, Masaki Yamamoto, Momo Hirata, Makoto Kudo, Sousuke Kubo, Takeshi Kaneko, and Saki Manabe more...
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business.industry ,medicine.medical_treatment ,Immune checkpoint inhibitors ,medicine ,Cancer research ,Identification (biology) ,In patient ,Immunotherapy ,Non small cell ,Lung cancer ,medicine.disease ,business ,Predictive biomarker - Published
- 2020
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14. Lymphocytic Infiltration in the Bronchial Glands of Sjogren's Syndrome
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H. Kitamura, T. Ogura, R. Shintani, A. Sekine, E. Tabata, Takashi Niwa, E. Hagiwara, Ryo Okuda, S. Komatsu, T. Oda, T. Takemura, T. Baba, R. Ootoshi, H. Okabayashi, and S. Ikeda
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Pathology ,medicine.medical_specialty ,Lymphocytic infiltration ,business.industry ,Bronchial glands ,Medicine ,Sjogren s ,business - Published
- 2020
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15. δ-Tocotrienol suppresses tumorigenesis by inducing apoptosis and blocking the COX-2/PGE2 pathway that stimulates tumor–stromal interactions in colon cancer
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Yuji Naito, Y. Matsushita, Sayori Wada, E. Minami, M. Kawai, Wataru Aoi, S. Ikeda, Akane Higashi, M. Nouchi, and Yoshikawa Toshiichi
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0301 basic medicine ,medicine.medical_specialty ,Stromal cell ,Colorectal cancer ,Medicine (miscellaneous) ,medicine.disease_cause ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Interferon ,Internal medicine ,medicine ,Vitamin E ,TX341-641 ,Colon adenocarcinoma ,Stromal cells ,Nutrition and Dietetics ,Azoxymethane ,business.industry ,Nutrition. Foods and food supply ,Cancer ,medicine.disease ,030104 developmental biology ,Endocrinology ,chemistry ,δ-Tocotrienol ,Apoptosis ,030220 oncology & carcinogenesis ,Cancer research ,Tocotrienol ,Carcinogenesis ,business ,Food Science ,medicine.drug - Abstract
Anticancer effects of δ-tocotrienol have been reported for several types of cancer, but have not been fully elucidated in colorectal cancer. We investigated the anti-proliferative effect of tocotrienols in vitro, in colon epithelial cells and stromal cells, and in vivo, in an induced colorectal cancer mouse model. Of the four isoforms tested, δ-tocotrienol exerted the most potent anti-proliferative effect on colon adenocarcinoma cells. δ-Tocotrienol reduced the nitrite and prostaglandin E2 (PGE2) concentrations in mouse embryonic fibroblasts (MEFs) pretreated with δ-tocotrienol and stimulated with lipopolysaccharide (LPS) and interferon γ. Furthermore, supernatants of LPS-stimulated MEFs promoted adenocarcinoma cell proliferation, while δ-tocotrienol treatment suppressed this effect. Additionally, a δ-tocotrienol-enriched diet significantly suppressed tumor formation in azoxymethane and dextran sulfate sodium-treated mice. Taken together, these data suggest that a δ-tocotrienol-enriched diet prevents colorectal cancer. At the molecular level, tocotrienols exert a direct anti-proliferative effect on colon adenocarcinoma cells, and an indirect, stromal cell-mediated, anti-proliferative effect. more...
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- 2017
16. Artery of Percheron pseudoaneurysm
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Charles A Miller and Daniel S. Ikeda
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medicine.medical_specialty ,business.industry ,General Medicine ,medicine.disease ,Artery of Percheron ,Pseudoaneurysm ,medicine.anatomical_structure ,Neurology ,Physiology (medical) ,Medicine ,Surgery ,Neurology (clinical) ,Radiology ,business - Published
- 2020
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17. P176 Left ventricular diastolic function by gated myocardial perfusion SPECT strongly reflects NT-ProBNP
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H Shinboku, K Otsuka, Takahiro Muroya, S Hata, S Kusumoto, K Maemura, S Ikeda, K Sakai, and K Sonoda
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Diastole ,Single-photon emission computed tomography ,medicine.disease ,Brain natriuretic peptide ,Myocardial perfusion imaging ,Heart failure ,Internal medicine ,medicine ,Cardiology ,Diastolic function ,Cardiology and Cardiovascular Medicine ,business ,Heart failure with preserved ejection fraction ,Perfusion - Abstract
Background The importance of left ventricle diastolic dysfunction (LVDD) has been recognized widely, as it is well established that heart failure with preserved ejection fraction has a poor prognosis. Furthermore, N-terminal pro–B-type natriuretic peptide (NT-ProBNP) is used as a marker of heart failure. However, the association between LVDD and NT-proBNP is unclear. Purpose The aim of this study was to clarify the association between LVDD and NT-ProBNP. Methods In this study, an index based on gated myocardial perfusion SPECT using CardioREPO software for the diagnosis of LVDD was used. Out of the 171 patients who underwent myocardial perfusion imaging (MPI) between January 2015 and December 2018, 163 individuals (116 men and 47 women) completed MPI and NT-ProBNP. Patients were classified into 4 groups: NT-ProBNP levels below 125 pg/ml (n = 52), NT-ProBNP levels 125 to 400 pg/ml (n = 33), NT-ProBNP levels 400 to 900 pg/ml (n = 23), and NT-ProBNP levels over 900 pg/ml (n = 37). CardioREPO parameters (peak filling rate (PFR), 1/3 mean filling rate (MFR), and time to peak filling rate/R-R (TTPFR)) were compared between the 4 NT-ProBNP groups. Results Of the 163 patients, 55 had LVDD. The PFR and 1/3MFR were associated with LVDD. There was a statistically significant difference in PFR and 1/3 MFR between the NT-ProBNP levels below 125 pg/ml group and the NT-ProBNP levels 400 to 900 pg/ml group (PFR = 2.51+/-1.11 vs. 1.80+/-0.65, p = 0.001; 1/3 MFR = 1.41+/-0.55 vs. 1.06+/-0.47, p = 0.006, Table). Conclusions The MPI indices obtained by CardioREPO software were useful in the diagnosis of LVDD. The evaluation of LVDD by MPI correlated with NT-Pro BNP level is thought to have a clinical utility in the diagnosis and management of LVDD. Variable: NT-ProBNP 0-125 (n = 52) 125-400 (n = 33) 400-900 (n = 23) 900- (n = 37) p Age 66 ± 11 72 ± 11 68 ± 17 70 ± 12 0.133 Male 40 (77%) 22 (12%) 18 (78%) 23 (62%) 0.36 Left ventricular diastolic dysfunction 8 (15%) 4 (12%) 10 (43%) 27 (73%) more...
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- 2020
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18. Neurosurgery Case Review: Questions and Answers
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Christian A. Bowers, Flavio Giordano, Faisal Abdulhamid Farrash, Pascal M. Jabbour, Alan Siu, Ramez Malak, Donald C. Shields, Unwar Ul-Haq, Jared J. Marks, Francisco Sanz, Achal Patel, Edward C. Benzel, Nabeel S. Alshafai, Hasel W. Slone, Jason S. Goldberg, Fahad Eid Alotaibi, Mohammad Almubaslat, Kamlesh B. Patel, Glenn C. Hunter, Anna Zicca, Michel Lacroix, Ibrahim Althubaiti, H. Francis Farhadi, Ahmed Mohyeldin, Robert L. Tiel, Homoud Aldahash, Claude-Edouard Châtillon, Franco DeMonte, Ossama Al-Mefty, Roberto Rafael Herrera, Nicholas J. Erickson, Nazer H. Qureshi, André Beer-Furlan, Judith Marcoux, Abdulrahman Yaqub Alturki, Ahmed Alaqeel, Badih Daou, Turki Elarjani, Sandeep Mittal, Kathleen E. Knudson, Alvin Chan, Amin B. Kassam, Kelsey A. Walsh, Mohammed Alghamd, Alfio Spina, Richard Bucholz, Fred Gentili, Marguerite Harding, Ricardo L. Carrau, Alwin Camacho, Pablo González-López, Faisal Al-Otaibi, Cristian Gragnaniello, Abdulrahman J. Sabbagh, Asem Salma, Stephen J. Hentschel, Joung H. Lee, Fahad AlKherayf, Rory Mayer, Rihaf Algain, John Woulfe, Stephen M. Russell, Han Zhuang Beh, Perry S. Bradford, Andrew Smith, Frederick Boop, Jorge E. Isaza, Vishal Patel, Eddie Perkins, Abdulrahman Albakr, Ibrahim Omeis, Christopher D. Baggott, Kevin Petrecca, Bassem Yousef Sheikh, Shaymaa Al-Umran, Michele Bailo, Jonathon Lebovitz, Pratap Chand, Edgar Gerardo Ordóñez-Rubiano, Aaron S. Gaekwad, Mohammed Almekhlafi, Jonathan Yun, Dimitri Sigounas, Julius July, Joseph A. Shehadi, Gustavo D. Luzardo, Ennio Antonio Chiocca, Shaan M. Raza, Alberto L. Gallotti, Anup Aggarwal, Ali Luqman, Mohammad A. Aziz-Sultan, Isabella Esposito, Eka Julianta Wahjoepramono, Imad N. Kanaan, Abdulrazag Ajlan, Hosam Al-Jehani, Brian Gill, Jaime Gasco, Brian Seaman, William T. Couldwell, José Luis Ledesma, Gary L. Gallia, Ananth K. Vellimana, Mark G. Hamilton, Da’Marcus Baymon, Almunder Algird, Evan S. Marlin, Ahmad I. Lary, Rudiger Von Ritschl, Afnan Uthman Alkhotani, Kevin Phan, Ayman Abdullah Albanyan, Essam A. Al Shail, Joshua Loewenstein, Mohammad Misfer Alshardan, Denis Klironomos, Ehtesham Ghani, Hector P. Rojas, Jeffery Atkinson, Matthew D. Smyth, Eldad J. Hadar, Erol Veznedaroglu, Mark A. Mahan, Qasim Al Hinai, Iván Verdú-Martínez, Peter J. Mews, Mohamed A. Labib, Randy L. Jensen, Rahul Shah, Amal Mokeem, Rolando Del Maestro, Denis Sirhan, Albert M. Isaacs, José Luis Montes, Mariam Alrashid, Jason Tullis, Hussam Abou-Al-Shaar, Justin Reagan, Daniel S. Ikeda, Pietro Mortini, David Sinclair, Hubert Lee, Mazda K. Turel, Michael S. Taccone, Alexander Y. Lin, Stephano Chang, Patrick Kim, Paul Steinbok, Luke G. F. Smith, Sami Obaid, Ashwag Al-Qurashi, Andrew Shaw, Abdul Haseeb Naeem, Exequiel P. Verdier, Ahmed Jaman Alzahrani, Lahbib A. Soualmi, Remi Nader, Ralph J. Mobbs, Soha Abdu M. Alomar, Mohammed Saeed Bafaqeeh, Zachary N. Litvack, Weston T. Northam, Joaquin Hidalgo, Robert F. Keating, Amgad S. Hanna, Jared Fridley, Bassam M. J. Addas, Monish Maharaj, Diana Ghinda, Daniel M. Prevedello, John S. Myseros, Lorenzo Genitori, Layla Batarfi, Khalid N. Almusrea, Samer K. Elbabaa, Adam Sauh Gee Wu, Anthony M. T. Chau, Naif M. Alotaibi, Saleh S. Baeesa, Kimberly Hamilton, Franz L. Ricklefs, Hashem Al Hashemi, Lissa Marie Peeling, Gareth Rutter, Sohum Desai, Philippe Mercier, Daniel Branch, Jorge E. Alvernia, Craig C. Weinkauf, Sunil Kukreja, Michel W. Bojanowski, Paul W. Gidley, Reem Bunyan, Domenic P. Esposito, Salah Baz, Randall C. Edgell, Christopher Evan Stewart, Burak Sade, Frank Gerold, Ali Alwadei, Nancy McLaughlin, Christopher J. Winfree, Terence Verla, Marc-Elie Nader, Andrew Jea, Filippo Gagliardi, Jean-Pierre Farmer, Giuliana Rizzo, Jeffrey P. Mullin, Ahmed T. Abdelmoity, Eric P. Roger, Anish Sen, Ivona Nemeiko, Mahmoud AlYamany, Anthony J. Caputy, Peter Nakaji, Nirmeen Zagzoog, Charles B. Agbi, Khalid Bajunaid, Matthew Pierson, Juan Ortega-Barnett, Justine Pearl, Maqsood Ahmad, Abdulmajeed Alahmari, and Robert A. Moumdjian more...
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Questions and answers ,medicine.medical_specialty ,Medical education ,business.industry ,medicine ,Neurosurgery ,business ,Neuroscience ,Case review - Published
- 2020
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19. EP991 Exceptional response with combined anti-hormone and MEK inhibitor therapy in a patient with hormone receptor-positive ovarian cancer and isolated KRAS alteration. Implications for a precision medicine strategy
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Steven C. Plaxe, S Ikeda, K Bamel, K Takahashi, Razelle Kurzrock, Shumei Kato, and Barbara A. Parker
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Oncology ,Trametinib ,medicine.medical_specialty ,Combination therapy ,business.industry ,medicine.medical_treatment ,Letrozole ,MEK inhibitor ,Cancer ,medicine.disease ,medicine.disease_cause ,Targeted therapy ,Internal medicine ,medicine ,KRAS ,business ,Tamoxifen ,medicine.drug - Abstract
Introduction/Background With advances in precision cancer medicine, personalized therapy approaches based on ‘omic’ analyses are being investigated. We present a patient with treatment refractory, metastatic ovarian cancer who achieved dramatic tumor reduction with a combination matched targeted therapy approach. Methodology Genomic aberrations were assessed using next-generation sequencing (NGS) from formalin-fixed paraffin embedded surgical tumor tissue (315 genes) (Foundation Medicine). Estrogen receptor (ER) was evaluated by immunohistochemistry (IHC). Patient was consented to our institutional Profile-Related Evidence Determining Individualized Cancer Therapy study (NCT02478931). Results A-40-year-old with serous papillary ovarian cancer presented after progression on 4 lines of systemic treatment. Evaluation with NGS from her initial surgery revealed only a single alteration, in KRAS G12V. In addition, IHC showed strong positivity for ER. Based on these findings, she was treated with trametinib (MEK inhibitor for KRAS alteration) and tamoxifen (estrogen receptor modulator for positive ER expression.) However, serial images showed gradual progression and the therapy was discontinued after 5 months. The patient was subsequently started on monotherapy with letrozole; however, after 3 months of treatment, the tumor progressed. Letroizole was continued and trametinib was restarted. The patient had a prompt and dramatic response (>50% tumor reduction per RECIST 1.1) with a precipitous decline in CA125 (fall to 243 U/ml from >15,000 U/ml at the time of reintroduction of tarmetenib). Treatment is ongoing 11+ months. Conclusion We report a patient with recurrent ovarian cancer with KRAS alteration and positive ER expression who demonstrated a remarkable response to combination therapy with a MEK inhibitor and aromatase inhibitor after failing treatment with the same MEK inhibitor in combination with a SERM. The current case suggests that different hormone modulators may have divergent effects and that selection of specific combination therapies for potentially pharmacologically tractable alterations can be effective. Disclosure Shumei Kato serves as a consultant for Foundation Medicine. Razelle Kurzrock receives research funding from Genentech, Incyte, Merck, Serono, Pfizer, Sequenom, Foundation Medicine, Grifols, and Guardant, as well as consultant fees from Loxo, X Biotech, NeoMed, and Actuate Therapeutics, speaker fees from Roche, and an ownership interest in IDby DNA and Curematch Inc. Barbara Parker receives research funding from Novartis, Genentech, Pizer, and Oncoternal Inc. This work was supported in part by Foundation Medicine, the Joan and Irwin Jacobs Fund philanthropic fund; and by National Cancer Institute at the National Institutes of Health [grant P30 CA023100 (Razelle Kurzrock, rkurzrock@ucsd.edu)]. more...
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- 2019
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20. EP629 Two young patients with endometrial cancer who newly developed double cancer in their ovaries after endometrial tumor disappearance through high-dose progesterone therapy and endometrial curettage
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N Susumu, E Saitoh, and S Ikeda
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medicine.medical_specialty ,Hysterectomy ,business.industry ,medicine.medical_treatment ,Endometrial cancer ,Uterus ,Urology ,medicine.disease ,Curettage ,medicine.anatomical_structure ,medicine ,Carcinoma ,Medroxyprogesterone acetate ,Ovarian cancer ,business ,Atypical Endometrial Hyperplasia ,medicine.drug - Abstract
Introduction/Background Standard treatment for endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) is total hysterectomy and bilateral salpingo-oophorectomy (BSO), however, young patients with early-stage EC and AEH in reproductive age often hope to preserve their fertility. The oncologic outcomes in long follow-up remain unclear especially regarding the incidences of recurrence or double cancer. We experienced two patients with EC who newly developed double cancer in their ovaries after medication of high-dose medroxyprogesterone acetate (MPA) for fertility-preservation. Methodology In principle, we survey the patients after MPA therapy every four months using vaginal ultrasound check, endometrial histological/cytological examinations, measurement of serum CA125, and pelvic MRI once a year. Results The 44 y/0 patient had received MPA therapy and cyclic surveillance every 4 to 6 months in the previous hospital, and she was introduced to our hospital with 3 year-recurrence-free interval. However, trans-vaginal (TV) echo showed solid tumor measuring 18 mm in diameter in the right ovary, and the serum CA125 was 32 U/ml. MRI revealed solid tumor with positive Gd-enhancement. Hysterectomy with RSO and LS were performed. Pathological examination revealed endometrioid carcinoma (EMC) G1 in uterus (pT1A), and mucin-producing EMC G1 in the right ovary (pT1A, primary ovarian cancer). Another 38 y/o patient had finished MPA therapy 4 months before. TV echo showed solid tumors measuring 30 mm in both ovaries, and the serum CA125 was 112 U/ml. MRI revealed solid tumors in both ovaries with positive Gd-enhancement. Hysterectomy with BSO, retroperitoneal lymphadenectomy was performed. Pathological examination revealed EMC G1 in uterus (pT1A), and mucin-producing EMC G2 in both ovaries (pT1B, bilateral primary ovarian cancers). Both patients have no recurrence after operation without adjuvant chemotherapy for 12 months. Conclusion Strictly careful follow-up every 4 months using TV echo and CA125 is needed after fertility-preserving MPA therapy for detecting heterochronous overlapping cancers in ovaries. Disclosure Nothing to disclose. more...
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- 2019
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21. P1549Serum soluble Klotho is associated with extent of coronary artery calcification in patients with stable angina pectoris undergoing percutaneous coronary intervention
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Hiroaki Kawano, S Ikeda, Tsuyoshi Yonekura, Ryohei Akashi, Yuki Yamagata, Seiji Koga, and K Maemura
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Percutaneous coronary intervention ,Soluble klotho ,urologic and male genital diseases ,Stable angina ,female genital diseases and pregnancy complications ,Internal medicine ,Coronary artery calcification ,medicine ,Cardiology ,In patient ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Klotho, which was originally identified as an aging suppressor, is a key regulator of bone and mineral metabolism. Transmembrane and soluble forms of Klotho protein have been identified. The transmembrane form serves as an obligate co-receptor for fibroblast growth factor 23 (FGF23). However, the physiological importance of soluble form of Klotho has not been determined. Purpose The present study aimed to test the hypothesis that circulating soluble Klotho levels can predict the presence or extent of coronary artery calcification (CAC) in patients with coronary artery disease. Methods We analyzed CAC of culprit lesions in patients with 75 stable angina pectoris who were not on dialysis and were scheduled for percutaneous coronary intervention (PCI) following intravascular ultrasound (IVUS). Arc and length of each calcium within the culprit lesion was measured by IVUS. The main outcome measure was the calcium index; a volumetric IVUS-derived measure which was calculated as total calcium length/lesion length × maximal calcium arc/360°. Low calcium index was defined as calcium index 460 pg/mL). Results Compared with patients with low-Klotho, those with high-Klotho had higher estimated glomerular filtration rate (eGFR) (69±20 vs. 55±16 mL/min/1.73 m2, p Conclusions Serum Klotho values were independently and inversely associated with the degree of CAC assessed by IVUS. These findings have important clinical implications for serum Klotho as a biomarker that reflects the extent of CAC. more...
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- 2019
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22. Working in Partnership with Individuals with Diabetes and Community Organizations to Prevent Disruption of Preventative Care During the COVID19 Pandemic
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E. Soares, M. Vega Avendano, F. Saballos Tercero, A. Sarmiento, O. Pabon, Barbara Hackley, F. Martinez Carvajal, J. Zhang, M. Stange, Z. Grullon, L. Hamilton, S. Ikeda, R. Thomas, and D. Herszenson
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Nutrition and Dietetics ,business.industry ,Community organization ,Tuesday, October 19 ,General Medicine ,medicine.disease ,Preventive care ,Nursing ,General partnership ,Diabetes mellitus ,Pandemic ,Medicine ,business ,Community and Population Health ,Food Science - Published
- 2021
23. PMH8 EQ-5D Analysis in Patients with Insomnia: Change of Quality of Life in Lemborexant Phase 3 Trial Sunrise 1
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M. Moline, K. Fujimoto, S. Inoue, M. Ishii, H. Shibahara, M. Azuma, and S. Ikeda
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medicine.medical_specialty ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,Lemborexant ,Quality of life (healthcare) ,EQ-5D ,Insomnia ,medicine ,Physical therapy ,Sunrise ,In patient ,medicine.symptom ,business - Published
- 2020
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24. 431P A randomized phase III trial comparing primary tumor resection plus chemotherapy with chemotherapy alone in incurable stage IV colorectal cancer: Updated results of JCOG1007 study (iPACS)
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Toshifumi Yamaguchi, Kohei Shitara, D. Shida, Yasumasa Takii, Masahiro Ito, Yukihide Kanemitsu, Junki Mizusawa, Kenji Katsumata, Hiroshi Katayama, J. Okuda, Haruhiko Fukuda, Hitoshi Ojima, Tetsuya Hamaguchi, S. Ikeda, A. Shiomi, Jun Watanabe, Suguru Hasegawa, Ryoji Hyakudomi, Yukako Shimada, and Koji Komori more...
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Oncology ,Chemotherapy ,medicine.medical_specialty ,Stage IV Colorectal Cancer ,business.industry ,medicine.medical_treatment ,Hematology ,medicine.disease ,Primary tumor ,Resection ,Internal medicine ,medicine ,business - Published
- 2020
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25. P2701Cardio-ankle vascular index can predict coronary plaque characteristics assessed by iMap-intravascular ultrasound
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S Ikeda, Yuji Koide, Tsuyoshi Yonekura, Hiroaki Kawano, Seiji Koga, Takahiro Muroya, K Maemura, and Ryohei Akashi
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medicine.medical_specialty ,Index (economics) ,medicine.anatomical_structure ,medicine.diagnostic_test ,business.industry ,Coronary plaque ,Internal medicine ,Intravascular ultrasound ,Cardiology ,Medicine ,Ankle ,Cardiology and Cardiovascular Medicine ,business - Published
- 2018
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26. P5596Circulating soluble Klotho is inversely associated with coronary artery calcification evaluated by three-dimensional intravascular ultrasound
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Hiroaki Kawano, S Ikeda, Yuji Koide, Yuki Yamagata, Seiji Koga, K Maemura, Ryohei Akashi, Tsuyoshi Yonekura, and Takahiro Muroya
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Soluble klotho ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Coronary artery calcification ,Intravascular ultrasound ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Published
- 2018
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27. P3185Unexpectedly-high prevalence of coronary stenosis in coronary artery calcification score 0 group: chest symptom and high suita score recommend further examination
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Y Sato, T. Kuragaichi, T Miyamoto, and S Ikeda
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medicine.medical_specialty ,High prevalence ,business.industry ,Internal medicine ,Coronary artery calcification ,medicine ,Cardiology ,Coronary stenosis ,Cardiology and Cardiovascular Medicine ,business - Published
- 2018
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28. P3708Evaluation of left ventricular diastolic function by echocardiography and gated myocardial perfusion SPECT: cardiorepo vs ASE/EACV guidelines and standards (2016)
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K Sonoda, S Kusumoto, S Hata, S Ikeda, Y Matsumoto, K Maemura, H Seto, and H Shinboku
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medicine.medical_specialty ,business.industry ,Internal medicine ,Cardiology ,Medicine ,Diastolic function ,Cardiology and Cardiovascular Medicine ,business ,Perfusion - Published
- 2018
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29. P1632Oxidative stress-responsive apoptosis inducing protein (ORAIP), a new oxidative stress marker, is associated with pulmonary hemodynamics in chronic thromboembolic pulmonary hypertension
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Yuji Koide, Masamichi Eguchi, Hiroaki Kawano, S Ikeda, Y Seko, Tomoo Nakata, T Yao, Tsuyoshi Yonekura, K Maemura, Seiji Koga, Yuki Yamagata, and Takahiro Muroya
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medicine.medical_specialty ,Apoptosis ,business.industry ,Internal medicine ,Oxidative stress marker ,medicine ,Cardiology ,Chronic thromboembolic pulmonary hypertension ,Cardiology and Cardiovascular Medicine ,business ,Pulmonary hemodynamics - Published
- 2018
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30. 2001 Volvo Award Winner in Clinical Studies: Lumbar Fusion versus Nonsurgical Treatment for Chronic Low Back Pain: A Multicenter Randomized Controlled Trial from the Swedish Lumbar Spine Study Group *
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Andrew Shaw, H. Francis Farhadi, and Daniel S. Ikeda
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medicine.medical_specialty ,Lumbar ,Randomized controlled trial ,law ,business.industry ,Medicine ,Lumbar spine ,business ,Nonsurgical treatment ,law.invention ,Surgery ,Chronic low back pain - Published
- 2018
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31. The long-term trends of ovarian cancer: A population-based cancer registry data in osaka from 1980 to 2012
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Asami Yagi, Y. Ueda, and S. Ikeda
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Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,Obstetrics and Gynecology ,Medicine ,Population based ,business ,Ovarian cancer ,medicine.disease ,Term (time) ,Cancer registry - Published
- 2019
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32. Endovascular flow diversion therapy for an actively hemorrhaging aneurysm after intraoperative rupture
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Daniel S. Ikeda, Evan S. Marlin, David Dornbos, Andrew Shaw, and Ciaran J. Powers
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medicine.medical_specialty ,Subarachnoid hemorrhage ,Ruptured aneurysms ,medicine.medical_treatment ,Aneurysm, Ruptured ,Aneurysm ,Aneurysm treatment ,Physiology (medical) ,medicine.artery ,medicine ,Humans ,cardiovascular diseases ,Embolization ,Intraoperative Complications ,Flow diversion ,business.industry ,Endovascular Procedures ,Intracranial Aneurysm ,General Medicine ,Middle Aged ,medicine.disease ,Embolization, Therapeutic ,Surgery ,Neurology ,cardiovascular system ,Female ,Neurology (clinical) ,Radiology ,Internal carotid artery ,business ,Parent vessel - Abstract
We report a 56-year-old woman who had an unruptured posterior communicating artery aneurysm. Given the size and location of the aneurysm, as well as her history of smoking and age, she received endovascular treatment with the pipeline embolization device (PED; ev3 Endovascular, Plymouth, MN, USA), complicated by intraoperative rupture (IOR). Flow diversion therapy with the PED has become an increasingly popular method of aneurysmal embolization and parent vessel remodeling. While its on-label approval is for large unruptured aneurysms of the internal carotid artery, success in off-label scenarios has been reported, including ruptured aneurysms. IOR complicates endovascular aneurysm treatment and can cause devastating morbidity or mortality, necessitating acute embolization of the hemorrhaging aneurysm. This patient illustrates the feasibility of treating an IOR with a stand-alone flow diversion device by using PED. more...
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- 2015
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33. Novel Tunneling System for Implantation of Percutaneous Nerve Field Stimulator Electrodes: A Technical Note
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Milind Deogaonkar, Daniel S. Ikeda, Zion Zibly, Andrew Shaw, and Ahmed Mohyeldin
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medicine.medical_specialty ,Percutaneous ,business.industry ,Technical note ,General Medicine ,Silastic ,Pain management ,Neuromodulation (medicine) ,Electrodes, Implanted ,Surgery ,Stylet ,Peripheral nerve field ,Catheters, Indwelling ,Anesthesiology and Pain Medicine ,Neurology ,Transcutaneous Electric Nerve Stimulation ,Humans ,Neuralgia ,Pain Management ,Medicine ,Blunt needle ,Neurology (clinical) ,business - Abstract
Introduction The field of neuromodulation continues to grow, especially in the area of pain management. Percutaneous nerve field stimulation continues to gain significant popularity for chronic, focal, and intractable neuropathic pain. Materials and Methods Tuohy needles have been traditionally used as the instrument of choice for subcutaneous implantation of peripheral field stimulators. The ON-Q® Tunneling System (Braun Melsungen AG, Melsungen, Germany) provides an adaptable option for subcutaneous implantation of electrodes, with a variety of lengths and gauges available. This system uses a disposable blunt needle and a peel-away sheath and is firm but malleable. Gentle curves can be applied to the stylet prior to implantation. The blunt, malleable nature of the needle and the soft Silastic sheath allow for applications in areas with greater curvature, such as the face, and ensure a subcutaneous placement. Conclusions The great adaptability of this system allows for implantation of electrodes subcutaneously with efficacy and ease. Here we present a technical note on the use of this system for subcutaneous implantation of peripheral nerve field stimulators. more...
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- 2015
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34. An elevated preoperative serum carbohydrate antigen 19-9 level is a significant predictor for peritoneal dissemination and poor survival in colorectal cancer
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Takashi Urushihara, Y. Imaoka, S. Ikeda, Toshiyuki Itamoto, and Yuji Takakura
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Adult ,Male ,Oncology ,medicine.medical_specialty ,Multivariate analysis ,CA-19-9 Antigen ,endocrine system diseases ,Colorectal cancer ,medicine.medical_treatment ,Disease ,Young Adult ,Carcinoembryonic antigen ,Laparotomy ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,Stage (cooking) ,Peritoneal Neoplasms ,Aged ,Retrospective Studies ,Aged, 80 and over ,biology ,business.industry ,Carcinoma ,Gastroenterology ,Middle Aged ,Prognosis ,medicine.disease ,digestive system diseases ,Carcinoembryonic Antigen ,Logistic Models ,Multivariate Analysis ,Preoperative Period ,biology.protein ,Female ,CA19-9 ,Neoplasm Recurrence, Local ,Colorectal Neoplasms ,business ,Carbohydrate antigen - Abstract
Aim Many studies support the role of carcinoembryonic antigen (CEA) as a strong indicator of the status of colorectal cancer patients, but evidence for carbohydrate antigen 19-9 (CA19-9) is poor. For this reason the study aimed to evaluate the prognostic value of preoperative serum CA19-9 levels in colorectal cancer patients. Method In all, 1190 colorectal cancer patients were included in this study, of whom 955 underwent a potentially curative resection. These were analysed for recurrence and survival. The 255 patients with Stage IV disease were analysed for metastatic status. Results Patients with an elevated preoperative CEA with Stage II and III disease showed a significantly poorer survival than those with normal levels. In contrast patients with elevated preoperative CA19-9 levels were associated with a significantly poorer survival irrespective of disease stage. Of the 255 patients with Stage IV disease, 92 (39.1%) had peritoneal dissemination at laparotomy observed more frequently in patients with an elevated CA19-9 (47.9%). Of the 955 patients having a curative resection, 18 (1.9%) developed peritoneal dissemination. In multivariate analysis, an elevated preoperative CA19-9 level was a significant risk factor for postoperative peritoneal recurrence. Conclusion After curative surgery for colorectal cancer the preoperative CA19-9 level is a strong prognostic indicator of higher risk of peritoneal dissemination. more...
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- 2015
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35. Precision Medicine: Current Practice and Future Perspective in the U.S
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S. Ikeda
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Future perspective ,Current practice ,business.industry ,Medicine ,Engineering ethics ,Precision medicine ,business - Published
- 2017
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36. Abstract WP309: Utilization of a Patient Selection Protocol for Mechanical Thrombectomy in Acute Ischemic Stroke Improves Outcomes
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Daniel S. Ikeda, Blake H. Priddy, Patrick Youssef, Shahid M Nimjee, David Dornbos, Joshua L. Wang, Ciaran J. Powers, and Evan S. Marlin
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Advanced and Specialized Nursing ,Protocol (science) ,medicine.medical_specialty ,business.industry ,medicine.disease ,Mechanical thrombectomy ,Time windows ,Emergency medicine ,Medicine ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Acute ischemic stroke ,Stroke ,Selection (genetic algorithm) - Abstract
Introduction: The emergence of mechanical thrombectomy has extended the time window for treatment of acute ischemic stroke and improved patient outcomes. Our institution developed a patient selection protocol aimed to improve patient outcomes following the procedure. Hypothesis: Implementation of a patient selection protocol based on evidence-based best practices improves patient outcomes following endovascular intervention in acute ischemic stroke. Methods: In January 2015, our institution developed a patient selection protocol for anterior circulation stroke, including patients with a documented large vessel occlusion, an NIH stroke scale ≥6, a pre-morbid modified Rankin Scale (mRS) ≤2, and with the initial groin puncture within 6 hours of stroke onset. Patients were excluded if pre-morbid life expectancy was ≤90 days, CT perfusion demonstrated 2 test, unpaired t test, and multivariable logistic regression analysis where appropriate. Results: Forty patients underwent endovascular treatment prior to protocol implementation with 65 patients treated under the protocol. Protocol implementation resulted in improved rates of TICI 2B/3 revascularization (87.7% protocol, 57.5% pre-protocol; p Conclusions: The development and implementation of a patient selection protocol for endovascular treatment of large vessel occlusion improves revascularization rates and functional outcomes. more...
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- 2018
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37. Pediatric Neurovascular Disease
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Daniel S. Ikeda, Randy S. Bell, Ciaran J. Powers, Brian P Curry, and Shahid M Nimjee
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Long lasting ,medicine.medical_specialty ,Subarachnoid hemorrhage ,business.industry ,Arteriovenous malformation ,Disease ,medicine.disease ,Neurovascular bundle ,Clinical trial ,Patient population ,Ischemic stroke ,medicine ,business ,Intensive care medicine - Abstract
Pediatric cerebrovascular disease comprises a diverse set of rare but nevertheless impactful vascular abnormalities that, while similar in some respects to those conditions found in adults, often represent distinct entities with pathophysiology, associated risk factors, and prevention and treatment considerations unique to this patient population. In addition, despite their relative rarity, the clinical consequences in younger patients may be profound and long lasting, and the associated costs may be enormous. As such, an awareness of these lesions and their current treatments is of paramount importance. Advancements in microsurgical and endovascular approaches to pediatric cerebrovascular disease have significantly evolved. The rarity of these lesions and the difficulty in enrolling pediatric patients in controlled trials has made large-scale clinical trials difficult to accomplish, necessitating that the practitioner be adequately versed in the diagnosis and treatment of these lesions when caring for these patients. While this chapter endeavors to present a selection of important pediatric cerebrovascular lesions and disease processes, it cannot possibly describe the full breadth of cerebrovascular disease in such a small space, nor can it hope to present those entities it does discuss exhaustively. more...
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- 2018
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38. Successful Endovascular Reconstruction of a Recurrent Giant Middle Cerebral Artery Aneurysm with Multiple Telescoping Flow Diverters in a Pediatric Patient
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Daniel S. Ikeda, Andrew Shaw, Ciaran J. Powers, and Evan S. Marlin
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Telescoping series ,Middle Cerebral Artery ,medicine.medical_specialty ,medicine.medical_treatment ,education ,Fusiform Aneurysm ,Recurrence ,medicine.artery ,medicine ,Humans ,cardiovascular diseases ,Embolization ,Child ,Flow diverter ,business.industry ,Intracranial Aneurysm ,General Medicine ,Clipping (medicine) ,Embolization, Therapeutic ,nervous system diseases ,Surgery ,Pediatric patient ,Cerebrovascular Circulation ,Pediatrics, Perinatology and Child Health ,Middle cerebral artery ,cardiovascular system ,Female ,Neurology (clinical) ,Radiology ,business ,circulatory and respiratory physiology ,Pediatric population - Abstract
Intracranial aneurysms of the pediatric population are rare, but giant fusiform aneurysms (GFAs) of the middle cerebral artery (MCA) are common within this cohort of patients. These aneurysms are difficult to treat and often require advanced microsurgical skills, as they are usually not amenable to direct clipping. Here, we report the successful treatment of a recurrent GFA of the MCA with three telescoping Pipeline Embolization Devices 6 months after attempted clip reconstruction in a pediatric patient. more...
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- 2015
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39. IgG4-Related Disease: A New Etiology Underlying Diffuse Intracranial Dilating Vasculopathy
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Evan S. Marlin, Norman L. Lehman, Daniel S. Ikeda, David Dornbos, and Ciaran J. Powers
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Adult ,Pathology ,medicine.medical_specialty ,Subarachnoid hemorrhage ,Hypophysitis ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Aneurysm ,Fibrosis ,medicine ,Endocarditis ,Humans ,Inflammation ,business.industry ,Intracranial Aneurysm ,Subarachnoid Hemorrhage ,medicine.disease ,Cerebrovascular Disorders ,Heart failure ,Immunoglobulin G ,Etiology ,Surgery ,IgG4-related disease ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background Diffuse intracranial aneurysmal vasculopathy is a rare condition, previously described in patients with human immunodeficiency virus infection. IgG4-related disease (IgG4-RD) is a recognized inflammatory disease of systemic organs, leading to fibrosis of connective tissues. It also has been linked to inflammatory dilating aortic aneurysms, coronary vascular disease, hypophysitis, orbital pseudotumor, and pachymeningitis. It has not yet been described as a cause of diffuse intracranial dilating vasculopathy. Histologically, this disease is characterized by IgG4-plasma cell infiltration, fibrosis, and phlebitis. Case Description A 40-year-old woman presented with acute heart failure, valvular insufficiency, and mycotic coronary aneurysms, concerning for endocarditis. Infectious workup was negative. Concurrent neurovascular workup revealed intracranial aneurysms, appearing mycotic in origin. Despite aggressive treatment for more than 5 years, she suffered multiple episodes of subarachnoid hemorrhage from a progressive dilating intracranial vasculopathy. Serum IgG levels and aneurysm wall pathology were consistent with IgG4-RD. Conclusions This is the first reported case of a diffuse intracranial dilating vasculopathy secondary to IgG4-RD. Recognition of similar pathologic findings in clinical presentation and radiologic workup should prompt further rheumatologic workup and possible immunosuppressive therapies. more...
- Published
- 2017
40. Central monitoring as surgical quality assurance in a randomized controlled trial of the conventional technique versus the no-touch isolation technique for primary tumor resection in patients with colorectal cancer (Japan clinical oncology group study / JCOG1006)
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H. Ike, Masayuki Ohue, Naohiro Tomita, Shoichi Fujii, T. Kobatake, Toshihiko Sato, Toshimasa Yatsuoka, Yasuhiro Shimada, Yasumasa Nishimura, S. Ikeda, Manabu Shiozawa, Yasumasa Takii, Masayoshi Yasui, Yukihide Kanemitsu, T. Shingai, Hiroshi Katayama, Nobuhiro Takiguchi, and Koji Komori more...
- Subjects
Clinical Oncology ,medicine.medical_specialty ,Group study ,Isolation (health care) ,Colorectal cancer ,business.industry ,General Medicine ,medicine.disease ,Primary tumor ,Surgery ,law.invention ,Oncology ,Randomized controlled trial ,law ,medicine ,In patient ,business ,Conventional technique - Published
- 2019
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41. Synovial Chondromatosis of the Cervical Spine: A Case Report and Review of the Literature
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Daniel R. Boue, Daniel S. Ikeda, Zion Zibly, Andrew Shaw, Vinay Prasad, and Lance S. Governale
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Population ,Poison control ,Pathology and Forensic Medicine ,Facet joint ,Neck Injuries ,Young Adult ,Synovial chondromatosis ,Spinal cord compression ,medicine ,Humans ,education ,education.field_of_study ,business.industry ,Accidents, Traffic ,General Medicine ,medicine.disease ,Laminoplasty ,Surgery ,medicine.anatomical_structure ,Athletic Injuries ,Pediatrics, Perinatology and Child Health ,Cervical Vertebrae ,Differential diagnosis ,Synovial membrane ,business ,Chondromatosis, Synovial - Abstract
Synovial chondromatosis is a benign condition characterized by metaplastic changes of the synovial membrane typically affecting large joints. Cervical spine involvement is rare and has not been reported in a teenager. The authors report a case of cervical synovial chondromatosis in a 19-year-old male presenting with left-sided weakness and numbness from spinal cord compression. After gross total resection was accomplished via laminoplasty, the patient's presenting symptoms improved and continued to do so over the follow-up period. The likely cause of the synovial chondromatosis in this patient was repetitive neck trauma as a child from a motor vehicle accident and football. This case demonstrates that the pathophysiology of this rare entity can initiate in the pediatric population. Although rare, synovial chondromatosis should be considered in the differential diagnosis of calcified extradural masses in the teenage population. more...
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- 2014
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42. Vertebral artery dissection after neck extension in an adult patient with Klippel–Feil syndrome
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Daniel S. Ikeda, Ciaran J. Powers, Andrew P. Slivka, and David Dornbos
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medicine.medical_specialty ,Vertebral artery dissection ,Klippel–Feil syndrome ,Dissection (medical) ,Neck Injuries ,Physiology (medical) ,medicine ,Humans ,In patient ,Cervical fusion ,Head and neck ,Vertebral Artery Dissection ,Neck Pain ,medicine.diagnostic_test ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Cerebral Angiography ,Surgery ,Neurologic injury ,Neurology ,Klippel-Feil Syndrome ,Female ,Neurology (clinical) ,Radiology ,business ,Cerebral angiography - Abstract
The association between Klippel-Feil syndrome and vertebral artery dissection is quite rare. We report an adult patient with vertebral artery dissection and Klippel-Feil syndrome, to our knowledge only the third reported case of its kind. A 45-year-old woman with a known history of Klippel-Feil syndrome presented with occipital head and neck pain following forced neck extension. Diagnostic cerebral angiography revealed a high grade vertebral artery stenosis, consistent with vertebral artery dissection. Following 6 months of medical management, a repeat diagnostic angiogram revealed complete healing of the vessel. While cervical fusion, as seen in Klippel-Feil syndrome, has previously been shown to cause neurologic injury secondary to hypermobility, the association with vertebral artery dissection is incredibly rare. We hypothesize that this hypermobility places abnormal shear force on the vessel, causing intimal injury and dissection. Patients with seemingly spontaneous vertebral artery dissection may benefit from cervical spine radiography, and this predisposition to cerebrovascular injury strongly suggests further evaluation of vascular injury following trauma in patients with Klippel-Feil syndrome or other cervical fusion as clinically warranted. more...
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- 2014
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43. P2.18-08 The Necessity and Technique of the Upper Zone Lymph Node Dissection for Non-Small-Cell Carcinoma of the Left Upper Lobe
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S. Ikeda and T. Yokota
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Pulmonary and Respiratory Medicine ,medicine.anatomical_structure ,Oncology ,business.industry ,Carcinoma ,medicine ,Left upper lobe ,Non small cell ,Anatomy ,Dissection (medical) ,medicine.disease ,business ,Lymph node - Published
- 2019
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44. 320P Adjuvant chemotherapy comprising a paclitaxel and carboplatin regimen or paclitaxel and ifosfamide regimen for uterine carcinosarcoma, a single institutional retrospective study
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Mayu Yunokawa, S. Ikeda, Emi Noguchi, Yohei Ohtake, Kazuo Tamura, Tadaaki Nishikawa, Chikako Shimizu, Kan Yonemori, Akihiko Shimomura, Hiroyuki Yoshida, Tatsunori Shimoi, T. Kato, and M. Ishikawa
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Oncology ,medicine.medical_specialty ,Ifosfamide ,Adjuvant chemotherapy ,business.industry ,Retrospective cohort study ,Hematology ,Carboplatin ,chemistry.chemical_compound ,Regimen ,Paclitaxel ,chemistry ,Internal medicine ,medicine ,Uterine carcinosarcoma ,business ,medicine.drug - Published
- 2016
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45. Sandwich technique, peripheral nerve stimulation, peripheral field stimulation and hybrid stimulation for inguinal region and genital pain
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Daniel S. Ikeda, Milind Deogaonkar, Mayur Sharma, Zion Zibly, and Andrew Shaw
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Adult ,Male ,medicine.medical_specialty ,Percutaneous ,Testicular pain ,Inguinal Canal ,Stimulation ,Electric Stimulation Therapy ,Hernia, Inguinal ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,medicine ,Humans ,Genitalia ,Peripheral Nerves ,Herniorrhaphy ,Pain Measurement ,Retrospective Studies ,Pain, Postoperative ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Inguinal canal ,Surgery ,Peripheral ,Electrodes, Implanted ,Pain, Intractable ,Inguinal hernia ,medicine.anatomical_structure ,Treatment Outcome ,Anesthesia ,Neuropathic pain ,Neuralgia ,Female ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Ilioinguinal neuralgia (IG) and genitofemoral (GF) neuralgia following inguinal hernia repair is a chronic and debilitating neuropathic condition. Recently, peripheral nerve stimulation has become an effective and minimally invasive option for the treatment of refractory pain. Here we present a retrospective case series of six patients who underwent placement of peripheral nerve stimulation electrodes using various techniques for treatment of refractory post-intervention inguinal region pain.Six patients with post-intervention inguinal, femoral or GF neuropathic pain were evaluated for surgery. Either octopolar percutaneous electrodes or combination of paddle and percutaneous electrodes were implanted in the area of their pain. Pain visual analog scores (VAS), surgical complication rate, preoperative symptom duration, degree of pain relief, preoperative and postoperative work status, postoperative changes in medication usage, and overall degree of satisfaction with this therapy was assessed.All six patients had an average improvement of 62% in the immediate post-operative follow-up. Four patients underwent stimulation for IG, one for femoral neuralgia, and another for GF neuralgia. Peripheral nerve stimulation provided at least 50% pain relief in all the six patients with post-intervention inguinal region pain. 85% of patients indicated they were completely satisfied with the therapy overall. There was one treatment failure with an acceptable complication rate.Peripheral nerve or field stimulation for post-intervention inguinal region pain is a safe and effective treatment for this refractory and complex problem for patients who have exhausted other management options. more...
- Published
- 2016
46. Editorial
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Daniel S. Ikeda and E. Antonio Chiocca
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medicine.medical_specialty ,business.industry ,medicine ,General Medicine ,Perioperative ,Intensive care medicine ,business - Published
- 2012
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47. Phosphorylated MTOR in the spinal anterior horn cells of patients with sporadic amyotrophic lateral sclerosis
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S. Ikeda, Takuji Yasude, Emi Suzuki-Kouyama, Shinji Ohara, Nobutaka Arai, Kiyomitsu Oyanagi, Masao Ushiyama, T. Sakai, Hiroyuki Yahikozawa, and M. Yamazaki
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Pathology ,medicine.medical_specialty ,Neurology ,Anterior Horn Cell ,business.industry ,medicine ,Phosphorylation ,Neurology (clinical) ,Amyotrophic lateral sclerosis ,medicine.disease ,business ,PI3K/AKT/mTOR pathway - Published
- 2017
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48. Saline adaptation of granules in mesophilic UASB reactors
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Norio Kurosawa, N. Kimata-Kino, Tatsuki Toda, and S. Ikeda
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Biomaterials ,Salinity ,Animal science ,Waste management ,Anaerobic sludge ,Chemistry ,medicine.medical_treatment ,medicine ,Methane production ,Waste Management and Disposal ,Microbiology ,Saline ,Mesophile - Abstract
We exposed mesophilic up-flow anaerobic sludge blanket (UASB) reactors to high concentrations of NaCl to elucidate the saline adaptation capacity of their granular sludge. We operated 10 lab-scale UASB reactors at 37 °C and added NaCl to the influent either abruptly or gradually. With abrupt addition, NaCl concentrations were increased from 0 g L−1 to 20, 30, 35, 40, 45, or 50 g L−1. With gradual addition, the NaCl concentrations were gradually increased from 0 to 64 g L−1 or 0 to 40 g L−1. We successfully saline-adapted the granules up to 32 g NaCl L−1, while maintaining high reactor performance, suggesting that 32 g NaCl L−1 is a practical level for system operation. In the UASB reactors gradually exposed to 32 g L−1 NaCl, methane production decreased by only 13%. We also learned that combining abrupt and gradual salinity increases could shorten the adaptation period. Thus we were able to shorten the adaptation period to only 30 days by increasing the salinity abruptly to 20 g L−1, followed by gradual adaptation to 30 g NaCl L−1. more...
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- 2011
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49. PGI24 - COST-UTILITY ANALYSIS OF VITAMINE E AND PIOGLITAZONE IN ADDITION TO 2 YEARS OF LIFE-STYLE MODIFICATION THERAPY FOR NON-ALCOHOLIC STEATOHEPATITIS PATIENTS IN JAPAN
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M. Sato, T. Muto, and S. Ikeda
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Cost–utility analysis ,medicine.medical_specialty ,business.industry ,Life style ,Vitamine e ,Health Policy ,Public Health, Environmental and Occupational Health ,Non alcoholic ,medicine.disease ,Gastroenterology ,Internal medicine ,Medicine ,Steatohepatitis ,business ,Pioglitazone ,medicine.drug - Published
- 2018
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50. Medical Cost Estimation for Elderly Acute Myeloid Leukemia (Aml) Using Real World Data in Japan
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S Ikeda, K Nakamura, and K Kogushi
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Oncology ,medicine.medical_specialty ,Cost estimate ,business.industry ,Health Policy ,Internal medicine ,Public Health, Environmental and Occupational Health ,medicine ,Myeloid leukemia ,business ,Real world data - Published
- 2018
- Full Text
- View/download PDF
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