1. Lower probability and shorter duration of infections after COVID-19 vaccine correlate with anti-SARS-CoV-2 circulating IgGs
- Author
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Gianmaria Frigè, Sebastiano Pasqualato, Sara Gandini, Ieo Covid Team, Luca Mazzarella, Silvio Capizzi, Luca Pase, Fabrizio Mastrilli, Marina Mapelli, Gioacchino Natoli, Federica Facciotti, Pier Giuseppe Pelicci, Chiara Ronchini, Roberto Orecchia, Rita Passerini, Ronchini, C, Gandini, S, Pasqualato, S, Mazzarella, L, Facciotti, F, Mapelli, M, Frige', G, Passerini, R, Pase, L, Capizzi, S, Mastrilli, F, Orecchia, R, Natoli, G, and Pelicci, P
- Subjects
Male ,RNA viruses ,Viral Diseases ,Time Factors ,Coronaviruses ,Physiology ,Antibodies, Viral ,Biochemistry ,Medical Conditions ,Immune Physiology ,Medicine ,Public and Occupational Health ,Pathology and laboratory medicine ,Virus Testing ,Aged, 80 and over ,Vaccines ,Multidisciplinary ,Immune System Proteins ,Middle Aged ,Medical microbiology ,Vaccination and Immunization ,Antibodies, Anti-Idiotypic ,Body Fluids ,Infectious Diseases ,Viruses ,Female ,SARS CoV 2 ,Pathogens ,Anatomy ,Research Article ,Adult ,2019-20 coronavirus outbreak ,COVID-19, SARS-CoV2, IgG, antibodies ,COVID-19 Vaccines ,Coronavirus disease 2019 (COVID-19) ,SARS coronavirus ,Infectious Disease Control ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Science ,Immunology ,Antibody level ,Mass Vaccination ,Microbiology ,Antibodies ,Young Adult ,Immune system ,Diagnostic Medicine ,Virology ,Humans ,Saliva ,Aged ,Medicine and health sciences ,Biology and life sciences ,business.industry ,SARS-CoV-2 ,Organisms ,Viral pathogens ,COVID-19 ,Proteins ,Viral Vaccines ,Covid 19 ,Microbial pathogens ,Immunoglobulin G ,Preventive Medicine ,business - Abstract
The correlation between immune responses and protection from SARS-CoV-2 infections and its duration remains unclear. We performed a sanitary surveillance at the European Institute of Oncology (IEO) in Milan over a 17 months period. Pre-vaccination, in 1,493 participants, we scored 266 infections (17.8%) and 8 possible reinfections (3%). Post-vaccination, we identified 30 infections in 2,029 vaccinated individuals (1.5%). We report that the probability of infection post-vaccination is i) significantly lower compared to natural infection, ii) associated with a significantly shorter median duration of infection than that of first infection and reinfection, iii) anticorrelated with circulating antibody levels.
- Published
- 2022