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1. Cardiometabolic health nursing to improve health and primary care access in community mental health consumers: protocol for a randomised controlled trial.

2. Reducing work-related stress among health professionals by using a training-based intervention programme for leaders in a cluster randomised controlled trial

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3. Individualised computerised cognitive training (iCCT) for community-dwelling people with mild cognitive impairment (MCI): results on cognition in the 6-month intervention period of a randomised controlled trial (MCI-CCT study)

4. Using motivational interviewing to improve sleep quality among patients with hypertension attending a tertiary hospital in southern Nigeria: a randomized controlled trial

5. Clinical efficacy and safety of faecal microbiota transplantation in the treatment of irritable bowel syndrome: a systematic review, meta-analysis and trial sequential analysis

6. Awake prone positioning effectiveness in moderate to severe COVID-19 a randomized controlled trial. [version 2; peer review: 2 approved, 1 approved with reservations]

7. Clinical effectiveness of subsensory sacral neuromodulation in adults with faecal incontinence: the SUBSoNIC crossover RCT and mechanistic study

8. Effects of stimulating single acupoint and combination acupoints on diabetic gastroparesis: A randomised controlled trial study

9. Geriatric assessment with management for older patients with cancer receiving radiotherapy: a cluster-randomised controlled pilot study

10. The Eczema Bathing Study: Weekly versus daily bathing for people with eczema? Protocol of an online, randomised controlled trial [version 1; peer review: 1 approved, 2 approved with reservations]

11. A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol [version 2; peer review: 2 approved]

12. Efficacy and safety of ketogenic diet in infants with epilepsy: KIWE RCT

13. The efficacy of sildenafil therapy in dismal prognosis early-onset intrauterine growth restriction: the STRIDER RCT

14. Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial [version 3; peer review: 2 approved, 1 not approved]

15. Awake prone positioning effectiveness in moderate to severe COVID-19 a randomized controlled trial. [version 1; peer review: 2 approved, 1 approved with reservations]

16. High dose cotrimoxazole treatment in patients with severe COVID-19: A randomised controlled trial

17. Bezafibrate as treatment in males for Barth syndrome: CARDIOMAN, a double-blind, placebo-controlled crossover RCT

18. Effectiveness and cost-effectiveness of offering a chair-based yoga programme in addition to usual care in older adults with multiple long-term conditions: a pragmatic, parallel group, open label, randomised controlled trial [version 2; peer review: 2 approved]

19. Clinical effectiveness/child-patient and parent satisfaction of two topical fluoride treatments for caries: a randomised clinical trial

20. The Effectiveness and Cost-Effectiveness of the ‘Walk with Me’ Peer-Led Walking Intervention to Increase Physical Activity in Inactive Older Adults: Study Protocol for a Randomised Controlled Trial

21. Efficacy and safety of eculizumab in children with Shiga-toxin-producing Escherichia coli haemolytic uraemic syndrome: the ECUSTEC RCT

22. The effect of closed-loop glucose control on C-peptide secretion in youth with newly diagnosed type 1 diabetes: the CLOuD RCT

23. Can we achieve better trial recruitment by presenting patient information through multimedia? Meta-analysis of ‘studies within a trial’ (SWATs)

24. Effects of a text messaging smoking cessation intervention amongst online help-seekers and primary health care visitors: findings from a randomised controlled trial

25. Intravenous immunoglobulin treatment for encephalitis in children aged 6 months to 16 years: the IgNiTE RCT

26. A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol [version 1; peer review: 2 approved]

27. Designing a platform/adaptive randomised controlled trial for peripheral arterial disease (PAD) – The PAEDIS international platform trial development project [version 1; peer review: 2 approved, 1 approved with reservations]

28. Withdrawal of renin-angiotensin system inhibitors’ effect on estimated glomerular filtration rate in adults with advanced kidney disease: the STOP-ACEi RCT

29. Studying factual versus social cues as triggers of change in food behaviour

30. The INHABIT (synergIstic effect of aNtHocyAnin and proBIoTics in) Inflammatory Bowel Disease trial: a study protocol for a double-blind, randomised, controlled, multi-arm trial

31. Resuscitation with pre-hospital blood products in adults with trauma-related haemorrhagic shock: the RePHILL RCT

32. Autologous stem cell transplantation with low-dose cyclophosphamide to improve mucosal healing in adults with refractory Crohn’s disease: the ASTIClite RCT

33. Ulipristal acetate versus levonorgestrel-releasing intrauterine system for heavy menstrual bleeding: the UCON randomised controlled trial and mechanism of action study

34. Bilateral versus single internal thoracic coronary artery bypass grafting: the ART RCT

35. Intralesional bleomycin versus cryotherapy for treatment of cutaneous warts: a randomized controlled trial

36. The Randomised Evaluation of early topical Lidocaine patches In Elderly patients admitted to hospital with rib Fractures (RELIEF): feasibility trial protocol [version 2; peer review: 2 approved]

37. Virtual reality supported therapy for the negative symptoms of schizophrenia: the V-NeST feasibility RCT

38. A Randomised Controlled Trial of Early Vitrectomy and Intravitreal Antibiotics for Post-operative Exogenous Endophthalmitis (EVIAN study): study protocol for a feasibility trial [version 1; peer review: 2 approved]

39. The remote diet intervention to reduce Long COVID symptoms trial (ReDIRECT): protocol for a randomised controlled trial to determine the effectiveness and cost-effectiveness of a remotely delivered supported weight management programme for people with Long COVID and excess weight, with personalised improvement goals [version 2; peer review: 2 approved]

40. Subacromial spacers for adults with symptomatic, irreparable rotator cuff tears: the START:REACTS novel group sequential adaptive RCT

41. Neuromuscular electrical stimulation as an adjunct to standard care in improving walking distances in intermittent claudication patients: the NESIC RCT

42. Gefitinib and methotrexate to resolve tubal ectopic pregnancy: the GEM3 RCT

43. Halting the Canadian STRIDER randomised controlled trial of sildenafil for severe, early-onset fetal growth restriction: ethical, methodological, and pragmatic considerations

44. Effectiveness of a digital intervention versus alcohol information for online help-seekers in Sweden: a randomised controlled trial

45. Enclosing a pen in a postal questionnaire follow-up to increase response rate: a study within a trial [version 2; peer review: 2 approved]

46. Anti-TNF (adalimumab) injection for the treatment of adults with frozen shoulder during the pain predominant stage protocol for a multi-centre, randomised, double blind, parallel group, feasibility trial [version 2; peer review: 2 approved]

47. The Use of Control Group in the Sports Science Research: The Ethical Challenge

48. Buruli-RifDACC: Evaluation of the efficacy and cost-effectiveness of high-dose versus standard-dose rifampicin on outcomes in Mycobacterium ulcerans disease, a protocol for a randomised controlled trial in Ghana [version 2; peer review: 2 approved]

49. Rapid intrapartum test for maternal group B streptococcal colonisation and its effect on antibiotic use in labouring women with risk factors for early-onset neonatal infection (GBS2): cluster randomised trial with nested test accuracy study

50. Evaluation of the effect of nutritive versus non-nutritive pacifiers as adjuncts to local anaesthesia in male neonatal circumcision using the plastibell technique – A prospective randomised controlled study