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9 results on '"R. Serino"'

1. Intrathecal kappa free light chains as markers for multiple sclerosis

Author

D. Vecchio, G. Bellomo, R. Serino, E. Virgilio, M. Lamonaca, U. Dianzani, R. Cantello, C. Comi, and I. Crespi

Subjects
Medicine, Science
Abstract

Abstract Cerebrospinal fluid (CSF) kappa free light chain (KFLC) index has been described as a reliable marker of intrathecal IgG synthesis to diagnose multiple sclerosis (MS). Our aims were: (1) to compare the efficiency of KFLC through different interpretation approaches in diagnosing MS. (2) to evaluate the prognostic value of KFLC in radiologically and clinically isolated syndromes (RIS-CIS). We enrolled 133 MS patients and 240 with other neurological diseases (93 inflammatory including 18 RIS-CIS, 147 non-inflammatory). Albumin, lambda free light chain (LFLC) and KFLC were measured in the CSF and serum by nephelometry. We included two groups of markers: (a) corrected for blood-CSF barrier permeability: immunoglobulin G (IgG), KFLC and LFLC indexes. (b) CSF ratios (not including albumin and serum-correction): CSF KFLC/LFLC, CSF KFLC/IgG, CSF LFLC/IgG. KFLC were significantly higher in MS patients compared to those with other diseases (both inflammatory or not). KFLC index and CSF KFLC/IgG ratio showed high sensitivity (93% and 86.5%) and moderate specificity (85% and 88%) in diagnosing MS. RIS-CIS patients who converted to MS showed greater KFLC index and CSF KFLC/IgG. Despite OB are confirmed to be the gold-standard to detect intrathecal IgG synthesis, the KFLC confirmed their accuracy in MS diagnosis. A “kappa-oriented” response characterizes MS and has a prognostic impact in the RIS-CIS population.

Published
2020
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2. Role of the laboratory in monitoring patients receiving dual antiplatelet therapy

Author

Matteo Vidali, C. Cassani, M. Parrella, Patrizia Pergolini, M. Manzini, Roberta Rolla, M. R. Portalupi, Giorgio Bellomo, M. D. Prando, and R. Serino

Subjects
medicine.medical_specialty, Aspirin, business.industry, medicine.medical_treatment, Biochemistry (medical), Clinical Biochemistry, Hematology, General Medicine, Drug resistance, Clopidogrel, medicine.disease, Gastroenterology, Thrombosis, Surgery, Epinephrine, Angioplasty, Internal medicine, Medicine, Platelet aggregation inhibitor, Ticlopidine, business, medicine.drug
Abstract

Summary Introduction: The increasing demand for therapeutic monitoring in patients receiving antiplatelet therapy has been paralleled by the development of instruments and tests whose clinical usefulness is still under debate. We devised a laboratory approach to detect patients with antiplatelet resistance at risk to develop thrombotic events. Methods: One hundred and eighty patients, under aspirin and clopidogrel after angioplasty and stent implantation, were studied by PFA100® with collagen/epinephrine (CoEPI, cutoff 165s) cartridge and by Multiplate® using arachidonic acid (ASPItest, pos

Published
2012
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3. Antibodies against oxidized phospholipids in laboratory tests exploring lupus anti-coagulant activity

Author

Giorgio Bellomo, Emanuele Albano, Matteo Vidali, Patrizia Pergolini, Roberta Rolla, and R. Serino

Subjects
Adult, Male, medicine.medical_specialty, Translational Studies, Immunology, Phospholipid, Phosphatidylserines, Phosphatidylinositols, chemistry.chemical_compound, Internal medicine, Phosphatidylcholine, medicine, Cardiolipin, Humans, Immunology and Allergy, Phosphatidylinositol, Aged, Autoantibodies, Aged, 80 and over, Clotting factor, Phosphatidylethanolamine, medicine.diagnostic_test, Phosphatidylethanolamines, Phosphatidylserine, Middle Aged, Endocrinology, chemistry, Immunoglobulin G, Lupus Coagulation Inhibitor, Antibodies, Antiphospholipid, Phosphatidylcholines, Prothrombin Time, Female, Partial Thromboplastin Time, Lipid Peroxidation, Oxidation-Reduction, Partial thromboplastin time
Abstract

Summary Lupus anti-coagulants (LA) are a variety of anti-phospholipid antibodies characterized by their capacity to interfere with phospholipid-dependent coagulation assays. LA are increasingly recognized as important predictors of thrombosis. However, the antigen specificity of LA is still poorly characterized. Growing evidence indicates that oxidized phospholipids are among the targets of anti-phospholipid antibodies. This prompted us to investigate the role of IgG directed against different oxidized phospholipids in 164 subjects without clotting factor defects that were tested for the presence of LA using a LA-sensitive activate partial thromboplastin time (aPTT-FSL) and a screening/confirmation assay based on diluted Russell's viper venom test (dRVVT-PL). The response to aPTT-FSL was significantly (P

Published
2007
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4. Experimental acute kidney injury

Author

A. Kuma, S. Yamada, T. Miyamoto, R. Serino, M. Tamura, Y. Otsuji, K. Kohno, W. Y. Cho, M.-G. Kim, S.-K. Jo, H. K. Kim, J. C. Jado, B. Humanes, V. Lopez-Parra, S. Camano, J. M. Lara, E. Cercenado, A. Tejedor, A. Lazaro, M. Jansen, G. Castellano, A. Stasi, A. Intini, M. Gigante, A. M. Di Palma, C. Divella, G. S. Netti, C. Prattichizzo, P. Pontrelli, A. Crovace, F. Staffieri, E. Fiaccadori, N. Brienza, G. Grandaliano, G. B. Pertosa, L. Gesualdo, K. Xanthopoulou, I. Tsouchnikas, G. Ouzounidis, G. Kokaraki, R. Lagoudaki, C. Simeonidou, G. Karkavelas, E. Spandou, D. Tsakiris, K. Kallaras, R. Schneider, M. Meusel, B. B. Betz, C. Held, K. Moller-Ehrlich, M. Buttner-Herold, C. Wanner, G. Michael, C. Sauvant, A. Hosszu, Z. Antal, J. Hodrea, S. Koszegi, N. F. Banki, L. Wagner, L. Lenart, A. Vannay, A. J. Szabo, A. Fekete, A. Michael, T. Faga, M. Navarra, M. Andreucci, S. Lemoine, B. Pillot, M. Rabeyrin, A. Varennes, M. Ovize, L. Juillard, L. Gomes Santana, W. Silva Almeida, N. Schor, M. Watanabe, C. D. Fonseca, E. A. Pessoa, M. H. Mendonca, S. M. Fernandes, F. T. Borges, M. F. Vattimo, C. P. C. Ow, F. Tassone, M. P. Koeners, S. C. Malpas, R. G. Evans, C. Alfarano, M.-A. Guardia, P. Lluel, S. Palea, G.-H. Young, V.-C. Wu, D. E. Choi, J. Y. Jeong, Y. K. Chang, S. Chung, K. R. Na, S. S. Kim, K. W. Lee, Y. Yang, L. Zhang, P. Fu, Y. Zhao, X. Zhang, I. Jadot, A.-E. Decleves, V. Colombaro, B. Martin, V. Voisin, I. Habsch, E. Deprez, J. Nortier, N. Caron, T. Iwakura, T. Fujikura, N. Ohashi, H. Yasuda, Y. Fujigaki, C. F. Vasco, M. D. F. F. Vattimo, J. Draibe, Y. Y ld r m, O. Aba, Z. Y lmaz, A. K. Kadiroglu, M. E. Y lmaz, M. Gul, A. Ketani, L. Colpan, L. B. d. M. Neiva, J. Suller Garcia, A. S. d. Oliveira, M. A. Naves, R. P. L. Van Swelm, J. F. M. Wetzels, V. G. M. Verweij, C. M. M. Laarakkers, J. C. L. M. Pertijs, D. W. Swinkels, R. Masereeuw, J. Sereno, P. Rodrigues-Santos, H. Vala, P. Rocha-Pereira, J. Fernandes, A. Santos-Silva, F. Teixeira, F. Reis, A. Altuntas, H. R. Yilmaz, E. Uz, M. Demir, A. Gokcimen, D. S. Bayram, O. Aksu, M. T. Sezer, K. H. Yang, Y. J. Jung, D. Kim, A. S. Lee, S. Lee, K. P. Kang, S. K. Park, W. Kim, N. A. Junglee, C. R. Searell, M. M. Jibani, J. H. Macdonald, C.-C. Wu, C.-C. Chen, K.-C. Lu, Y.-F. Lin, G. R. Estrela, F. Wasinski, R. Pereira, D. Malheiros, N. O. S. Camara, R. C. Araujo, M. F. Ramos, C. d. S. Passos, C. V. Razvickas, F. Borges, M. Ormanji, E. Plotnikov, M. Morosanova, I. Pevzner, L. Zorova, V. Manskikh, M. Skulachev, V. Skulachev, D. Zorov, C. F. Pinto, M. Vattimo, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Institut National de la Recherche Agronomique (INRA)

Subjects
0303 health sciences, Transplantation, medicine.medical_specialty, business.industry, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, Acute kidney injury, Urology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Nephrology, Medicine, business, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology
Abstract

International audience

Published
2014
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5. Serum autoantibodies against cytochrome P450 2E1 (CYP2E1) predict severity of liver graft hepatitis C recurrence

Author

M. Colombo, F. Agnelli, Cristina Rigamonti, E. Arosio, Emanuele Albano, Maria Francesca Donato, A. Ivaldi, R. Serino, M. Vidali, G. Occhino, V. Monti, and Giorgio Rossi

Subjects
Liver graft, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Serum autoantibodies, Gastroenterology, medicine, Hepatitis C, CYP2E1, medicine.disease, business
Published
2007
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9. [561] OXIDATIVE STRESS AND INSULIN RESISTANCE CONTRIBUTE TO STEATOSIS IN HCV GENOTYPE NON-3 INFECTED PATIENTS

Author

Giuseppe Ruggiero, Matteo Vidali, Emanuele Albano, Rosa Zampino, R. Serino, Luigi Elio Adinolfi, Barbara Guerrera, Alessandra Ivaldi, and G. Occhino

Subjects
medicine.medical_specialty, Endocrinology, Insulin resistance, Hepatology, business.industry, Internal medicine, Genotype, medicine, Steatosis, medicine.disease_cause, business, medicine.disease, Oxidative stress
Published
2007
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