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Your search keyword '"Nitisha Sendri"' showing total 4 results
Start Over Author "Nitisha Sendri" Topic medicine
4 results on '"Nitisha Sendri"'

1. Impact of Chitosan‐ Prunus cerasoides gum exudates on the thermal properties, storage stability and antioxidant activity of anthocyanins from Berberis lycium Royle

Author

Sarvpreet Singh, Vinod Bhatt, Nitisha Sendri, and Pamita Bhandari

Subjects
Antioxidant, biology, medicine.medical_treatment, biology.organism_classification, Industrial and Manufacturing Engineering, Chitosan, chemistry.chemical_compound, chemistry, medicine, Prunus cerasoides, Thermal stability, Food science, Berberis lycium, Food Science
Published
2021

2. Copigmentation and UPLC-ESI-MS/MS of anthocyanin in Ipomoea nil as potential source of food colorant

Author

Nitisha Sendri, Pamita Bhandari, Vikram Patial, Swati Katoch, and Shinde Bhagatsing Devidas

Subjects
Antioxidant, 010405 organic chemistry, medicine.medical_treatment, Organic Chemistry, Uplc esi ms ms, Plant Science, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Nutraceutical, chemistry, Anthocyanin, medicine, Copigmentation, Potential source, Food science, Ipomoea nil
Abstract

Anthocyanins are good alternative to synthetic dyes for food, pharmaceutical and nutraceutical industries. Owing to their wide occurrence in plant kingdom, an UPLC-ESI-MS/MS method was used to iden...

Published
2020

4. Amelioration of cognitive deficit in zebrafish by an undescribed anthraquinone from Juglans regia L.: An in-silico, in-vitro and in-vivo approach

Author

Rahul Singh, Damanpreet Singh, Shinde Bhagatsing Devidas, Pamita Bhandari, Nitisha Sendri, Shubham Nilkanth Rahmatkar, and Rituraj Purohit

Subjects
0301 basic medicine, In silico, Anthraquinones, Juglans, Anthraquinone, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Memory, In vivo, medicine, Animals, Humans, Learning, Cognitive Dysfunction, Zebrafish, Pharmacology, Acrylamide, Natural product, biology, Neurotoxicity, biology.organism_classification, medicine.disease, Acetylcholinesterase, In vitro, Molecular Docking Simulation, Disease Models, Animal, Neuroprotective Agents, 030104 developmental biology, chemistry, Biochemistry, Cholinesterase Inhibitors, 030217 neurology & neurosurgery
Abstract

An undescribed anthraquinone assigned as 1-Hydroxy-5,5-dimethyl-5,6,7,8-tetrahydro-9,10-anthraquinone (compound 1) was isolated from ethylacetate extract of Juglans regia L. The structure of the compound was established on the basis of 1D, 2D NMR (HSQC, HMBC, COSY), ESI-QTOF-MS/MS spectroscopy. The molecular docking studies of compound 1 indicated similar molecular interactions as that of co-crystalized inhibitor. Compound 1 showed hydrogen bonds with residues PHE295, GLY121, π-σ interactions with TYR 341, π-π interactions with HIS 447 residues, and π-alkyl with TRP86 and TYR 337. On the basis of in-silico interaction studies of compound 1 with proteins, it was tested using acetylcholinesterase inhibition assay, acrylamide-induced neurotoxicity test of zebrafish larva, and scopolamine-induced cognitive deficit model of adult zebrafish. The compound 1 showed potent acetylcholinesterase inhibition activity, prevented acrylamide-induced neurotoxicity and improved learning and memory functions in T-maze test. The results established compound 1 to be a potential neuroprotective natural product for amelioration of cognitive impairment.

Published
2021

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