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Your search keyword '"Motoya Murakami"' showing total 4 results
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4 results on '"Motoya Murakami"'

1. Effects of Staphylococal Phage Lysate (SPL) on Immunoglobulin Production in Human Peripheral Lymphocyte Cultures

Author

Mikio Mizukoshi, Bunsho Lee, Motoya Murakami, Junichi Yada, and Noriaki Shinomiya

Subjects
Pharmacology, Lysis, biology, T cell, Lymphocyte, Pokeweed mitogen, Immunoglobulins, Pharmaceutical Science, Lymphocyte Activation, Virology, Microbiology, medicine.anatomical_structure, Bacteriocins, Pokeweed Mitogens, medicine, biology.protein, Humans, Macrophage, Lymphocytes, Staphylococcus Phages, Antibody, Gene, Cells, Cultured, B cell
Published
1985

2. Pharmacological studies on EB-382, a new non-steroidal antiinflammatory agent: Mode of action of the antiinflammatory effects

Author

Toshio Uematsu, Toshio Fujiyoshi, Motoya Murakami, Hiroyuki Iida, and Miho Kuwashima

Subjects
Male, Analgesics, Anti-Inflammatory Agents, Non-Steroidal, Prostaglandin, Bradykinin, Rats, Inbred Strains, General Chemistry, General Medicine, Pharmacology, Ibuprofen, Inhibitory postsynaptic potential, Rats, chemistry.chemical_compound, chemistry, Mechanism of action, Drug Discovery, medicine, Animals, Potency, Propionates, Prostaglandin E2, medicine.symptom, Mode of action, medicine.drug
Abstract

The mode of action of (+/-)-2-[p-[(2-methylallyl)amino]phenyl]propionic acid (EB-382) was studied in terms of its antiinflammatory effect. EB-382 displayed a more potent inhibitory effect than that of ibuprofen on carrageenin-induced paw edema in rats, and its inhibitory action was unaffected by adrenalectomy. EB-382 had a less potent inhibitory effect than that of ibuprofen on the prostaglandin E2 biosynthesis of 3T6 mouse fibroblast cells. EB-382 displayed a much more potent inhibitory effect than that of ibuprofen on carrageenin-induced pleurisy in rats. EB-382 exhibited a dose-dependent and significant inhibitory effect on the bradykinin and prostaglandin contents released into the pleural cavity in rat pleurisy induced by carrageenin, and its potency was much higher than that of ibuprofen. EB-382 strongly inhibited the leukocyte emigration into the pleural cavity, and its potency was almost equal to that of indomethacin. EB-382 did not affect the kinin-forming enzyme and kininase activities of rat plasma in vitro. The above results suggest that the antiinflammatory effect of EB-382 was probably due to inhibition of the production of bradykinin and prostaglandins derived from emigrating leukocytes in the local inflamed tissue besides a weak inhibitory effect on prostaglandin biosynthesis.

Published
1989

3. [Effects of Staphylococcus aureus Cowan I strain on the natural killer (NK) activity and interferon induction of mouse spleen cells in vitro]

Author

Hiroshi Ishikawa, Bunsho Lee, and Motoya Murakami

Subjects
Male, Mice, Inbred BALB C, Staphylococcus aureus, Interferon Inducers, Strain (chemistry), Nk activity, Mouse Spleen, Mice, Nude, General Medicine, Biology, medicine.disease_cause, Virology, In vitro, Microbiology, Killer Cells, Natural, Mice, Interferon, medicine, Animals, Interferons, Cells, Cultured, Spleen, medicine.drug
Published
1984

4. Pharmacological studies on EB-382, a new non-steroidal antiinflammatory agents: mode of action of the analgesic effects

Author

Toshio Fujiyoshi, Motoya Murakami, Hiroyuki Iida, Miho Kuwashima, and Toshio Uematsu

Subjects
Male, Analgesic, Prostaglandin, Mice, Inbred Strains, Pharmacology, chemistry.chemical_compound, Mice, Phospholipase A2, Drug Discovery, medicine, Animals, Prostaglandin E2, Mode of action, Sheep, biology, Anti-Inflammatory Agents, Non-Steroidal, Rats, Inbred Strains, General Chemistry, General Medicine, Rats, Mechanism of action, chemistry, biology.protein, Arachidonic acid, Female, Cyclooxygenase, medicine.symptom, Propionates, medicine.drug
Abstract

The analgesic mechanism of (+/-)-2-[p-[(2-methylallyl)amino]phenyl]propionic acid (EB-382), a new non-steroidal antiinflammatory agent, was studied. EB-382 exerted a potent analgesic effect on yeast-induced hyperalgesia in rats and bradykinin-induced writhing in mice, and its potency was superior to that of ibuprofen. EB-382 had a comparatively weak inhibitory effect on the prostaglandin E2 production from arachidonic acid in sheep seminal vesicle microsomal fraction in vitro. EB-382 exhibited a dose-dependent inhibitory effect on the phospholipase A2 activity in 3T3 mouse fibroblast cells with a different mechanism from steroidal agents, although indomethacin and ibuprofen did not reveal any significant inhibition. EB-382 did not affect the bradykinin-induced contraction of isolated rat uterus. Intracisternal injection of EB-382 did not affect the acetic acid-induced writhing response in mice. From these results, it is suggested that the analgesic effect of EB-382 in inflammation is exerted through its direct peripheral action, and inhibition of prostaglandin biosynthesis via phospholipase A2, rather than cyclooxygenase.

Published
1989

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