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Your search keyword '"Megumi Kurachi"' showing total 3 results
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3 results on '"Megumi Kurachi"'

1. Accumulation of L-type Bovine Prions in Peripheral Nerve Tissues

Author

Yoshifumi Iwamaru, Morikazu Imamura, Yuichi Matsuura, Kentaro Masujin, Yoshihisa Shimizu, Yujing Shu, Megumi Kurachi, Kazuo Kasai, Yuichi Murayama, Shigeo Fukuda, Sadao Onoe, Ken’ichi Hagiwara, Yoshio Yamakawa, Tetsutaro Sata, Shirou Mohri, Hiroyuki Okada, and Takashi Yokoyama

Subjects
atypical bovine spongiform encephalopathy, Creutzfeldt-Jacob disease, cattle, distribution, L-type, nerve tissues, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimentally challenged cattle. As with classical BSE prions, L-type BSE prions accumulated in central and peripheral nerve tissues.

Published
2010
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2. Accumulation of L-type Bovine Prions in Peripheral Nerve Tissues

Author

Yujing Shu, Tetsutaro Sata, Sadao Onoe, Kentaro Masujin, Shirou Mohri, Yoshifumi Iwamaru, Ken'ichi Hagiwara, Takashi Yokoyama, Shigeo Fukuda, Yuichi Matsuura, Yuichi Murayama, Kazuo Kasai, Yoshio Yamakawa, Yoshihisa Shimizu, Hiroyuki Okada, Morikazu Imamura, and Megumi Kurachi

Subjects
Microbiology (medical), Pathology, medicine.medical_specialty, Prions, Epidemiology, animal diseases, Bovine spongiform encephalopathy, Central nervous system, lcsh:Medicine, Biology, atypical bovine spongiform encephalopathy, lcsh:Infectious and parasitic diseases, prion, Pathogenesis, Creutzfeldt Jacob Disease, Peripheral nerve, mental disorders, distribution, medicine, transmissibility, Animals, lcsh:RC109-216, Peripheral Nerves, L-type, lcsh:R, Dispatch, food and beverages, nerve tissues, medicine.disease, Virology, zoonoses, nervous system diseases, Encephalopathy, Bovine Spongiform, Atypical bovine spongiform encephalopathy, Infectious Diseases, medicine.anatomical_structure, cattle, Creutzfeldt-Jacob disease, neurodegenerative disorder
Abstract

We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimentally challenged cattle. As with classical BSE prions, L-type BSE prions accumulated in central and peripheral nerve tissues.

Published
2010
Full Text
View/download PDF

3. Intraspecies transmission of L-type-like Bovine Spongiform Encephalopathy detected in Japan

Author

Kenâichi Hagiwara, Megumi Kurachi, Shigeo Fukuda, Morikazu Imamura, Tetsutaro Sata, Sadao Onoe, Kazuo Kasai, Shirou Mohri, Hiroyuki Okada, Yuichi Matsuura, Yoshihisa Shimizu, Kentarou Masujin, Yuichi Murayama, Takashi Yokoyama, Yoshifumi Iwamaru, and Yujing Shu

Subjects
Prions, animal diseases, Bovine spongiform encephalopathy, Immunology, Cattle Diseases, Biology, Microbiology, Incubation period, Infectious Disease Incubation Period, Prion Diseases, Mice, Japan, Species Specificity, Virology, mental disorders, medicine, Animals, PrPC Proteins, Prion protein, Medulla Oblongata, Atypical BSE, Transmission (medicine), food and beverages, Successful transmission, medicine.disease, nervous system diseases, Atypical bovine spongiform encephalopathy, Encephalopathy, Bovine Spongiform, Cattle, Spongiform encephalopathy
Abstract

It has been assumed that the agent causing BSE in cattle is a uniform strain (classical BSE); however, different neuropathological and molecular phenotypes of BSE (atypical BSE) have been recently reported. We demonstrated the successful transmission of L-type-like atypical BSE detected in Japan (BSE/JP24 isolate) to cattle. Based on the incubation period, neuropathological hallmarks, and molecular properties of the abnormal host prion protein, the characteristics of BSE/JP24 prion were apparently distinguishable from the classical BSE prion and closely resemble those of bovine amyloidotic spongiform encephalopathy prion detected in Italy.

Published
2009

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