Author: "Malena A" / Topic: medicine - Searchworks@Jio Institute Digital Library Search Results

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1. Pregled in ocena kazalcev bolezni otrok in mladostnikov s cistično fibrozo v Sloveniji

Author: Ana Drnovšek, Marina Praprotnik, Uroš Krivec, Malena Aldeco, Dušanka Lepej, Saša Šetina Šmid, Aleksandra Zver, Majda Oštir, Katja Seme, Jernej Brecelj, Anija Orel, Darja Šmigoc Schweiger, and Jasna Rodman Berlot
Subjects: otroci, pljučna funkcija, prehranjenost, mikrobiologija, zdravljenje, Medicine
Abstract: Izhodišča: Cistična fibroza (CF) je najpogostejša kronična avtosomno recesivno dedna bolezen belcev. Kaže se s prizadetostjo številnih organov, zato se bolniki spremljajo v centrih CF s specializiranim multidisciplinarnim timom strokovnjakov. Eden takih je center CF Pediatrične klinike Ljubljana, kjer se vodijo vsi otroci in mladostniki s CF v Sloveniji. Od ustanovitve centra dalje vodimo zbirko podatkov o bolnikih, ki nam je v pomoč pri analizi razmer in pri primerjavi kakovosti obravnave naših bolnikov z drugimi evropskimi centri CF. Metode: Izvedli smo retrospektivno raziskavo z namenom pregledati in oceniti kazalce bolezni otrok in mladostnikov s CF, vodenih na Pediatrični kliniki Ljubljana v letu 2020. Pri 78 vključenih bolnikih smo analizirali podatke o demografskih značilnostih, genetskih mutacijah, pljučni funkciji, prehranjenosti, kroničnih okužbah in zdravljenju s CFTR modulatornimi zdravili (angl. cystic fibrosis transmembrane conductance regulator, CFTR – regulator transmembranske prevodnosti pri cistični fibrozi). Za primerjavo z drugimi evropskimi centri smo uporabili podatke iz letnega poročila Evropskega registra CF za leto 2020. Rezultati: Leta 2020 smo v našem centru obravnavali 78 bolnikov, izmed katerih je bilo 56 % (44/78) bolnikov moškega spola. Povprečna starost bolnikov je znašala 13,2 leta (SD 6,4 let), z razponom od 1,2 leta do 25,5 leta. Mutacija F508del je bila najpogosteje zastopana, saj je bilo kar 88,5 % nosilcev vsaj ene, pri 64,1 % obolelih pa je bila mutacija prisotna na obeh alelih. Povprečni forsirani izdihani volumen v 1 sekundi (FEV1) naših bolnikov je bil nad evropskim povprečjem, prevalenca kronične okužbe s povzročiteljem Pseudomonas aeruginosa pa nižja od evropskega povprečja. V letu 2020 smo 21 bolnikom uvedli CFTR modulatorno zdravilo, od tega 5 bolnikom lumakaftor/ivakaftor in 16 bolnikom eleksakaftor/tezakaftor/ivakaftor. Zaključek: Kazalci kakovosti obravnave otrok in mladostnikov s CF v Sloveniji dosegajo in pogosto presegajo evropsko povprečje. Med prvimi državami v Evropi smo pričeli uvajati CFTR modulatorna zdravila, ki obetajo pomembno izboljšanje kliničnega stanja in kakovosti življenja bolnikov s CF.
Published: 2023
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2. Knowledge and professional practice on conservation of vaccines

Author: Malena Almeida, Telma Maria Evangelista Araújo, Benevina Maria Vilar Teixeira Nunes, Maria Eliete Batista Moura, and Maria do Carmo de Carvalho e Martins
Subjects: Vacinas, Imunização, Enfermagem, Medicine, Nursing, RT1-120
Abstract: Objetivo: Avaliar conhecimentos e práticas adotadas para conservação de imunobiológicos por profissionais de salas de vacina no Piauí. Método: Estudo desenvolvido nas 23 salas de vacina de 14 municípios. Os dados foram coletados por meio de entrevistas, observação e análise documental. Foram realizadas análises univariadas. Resultados: Nas 23 salas de vacinas visitadas, 86,2% dos profissionais eram técnico/auxiliar de enfermagem,93,1% receberam treinamento em vacinação, 62,1% tinham até cinco anos de trabalho em sala de vacina. A maioria (69%) apresentou conhecimento “Regular” e prática “Inadequada” (65,5%). O conhecimento “Inadequado” foi observado naqueles com maior tempo de formado (17,4 anos) e um maior tempo de sala de vacina (7 anos). Em contrapartida a prática classificada como “Regular” foi observada entre os que tinham maior tempo de trabalho em sala de vacina (8,3 anos). Conclusão: É importância investir na capacitação desses profissionais, uma vez que o conhecimento e a prática não foram considerados satisfatórios.
Published: 2014
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3. Hyponatremic hypochloremic dehydration in children with cystic fibrosis in Slovenia; the incidence and recommendations for prevention and treatment

Author: Marina Praprotnik, Gorazd Kalan, Nataša Bratina, Ivan Vidmar, Malena Aldeco, Dušanka Lepej, and Uroš Krivec
Subjects: cystic fibrosis, children, hyponatraemic dehidration, prevention, treatment, Medicine
Abstract: Background: Young children and rarely adolescents with cystic fibrosis can develop hyponatremic hypochloremic dehydration with metabolic alkalosis. The purpose of this article was to review the incidence of this metabolic disorder in our CF patients.Methods: We investigated the medical records of all children diagnosed with cystic fibrosis who are under follow-up in the CF center at the University Childrenʹs Hospital Ljubljana, and were hospitalised or treated on an outpatient basis due to hyponatremic, hypochloremic dehydration in the period from 2007–2012. Data analysis included clinical and laboratory findings.Results: A total of 4 children (7.2 %) from Ljubljana CF center (55 patients under the age of 19 years) were enrolled in the study. We observed 5 episodes of hyponatremic hypochloremic dehydration in 4 patients (one boy had two episodes). All were homozigous for ΔF 508 mutation. Two had episodes in summer and two in autumn, so that no season prevalence of its occurence was found. Median age at admission to the hospital due to hyponatremic hypochloremic dehydration was 7 months (range 4–34). One boy had a hypovolemic shock at the time of admission to the hospital.Conclusions: The results of our study show that dehydration with hypoelectrolytaemia is a rare complication in children with CF in Slovenia, but due to the severity of clinical signs it is an important disorder. Vomiting and fatigue are the warning signs that should alert parents and physicians to consider the possibility of this complication which can be prevented by proper hydration and salt replacement. If left untreated, it can cause seizures, arrhythmias and even death.
Published: 2015

4. Ethical Dilemma

Author: Eitan Kerem, Oded Breuer, Nadia Alyan, Isaiah D. Wexler, Malena Cohen-Cymberknoh, Joel Reiter, David Shoseyov, and Shifra Koretz
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, biology, business.industry, media_common.quotation_subject, medicine.medical_treatment, Disease, Odds ratio, Critical Care and Intensive Care Medicine, medicine.disease, Cystic fibrosis, Cystic fibrosis transmembrane conductance regulator, Ivacaftor, Ethical dilemma, medicine, biology.protein, Lung transplantation, Cardiology and Cardiovascular Medicine, Intensive care medicine, business, Autonomy, medicine.drug, media_common
Abstract: Cystic fibrosis is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. Novel, highly effective, modulator therapies correcting and potentiating CFTR function are changing the course of the disease. We present an ethical dilemma involving an 11-year-old child with CF and end stage lung disease. Shortly after starting treatment with Elexacaftor-Tezacaftor-Ivacaftor, the family received notification that a matched donor lung had been allocated. Clinical decision-making in this case is challenging as definitive data to medically support one treatment option over the other is limited. A survey of CF center team members was conducted for the purpose of this manuscript. Ethical principles that may guide us in these situations are discussed. Overall, results of the survey present a lack of agreement as to the best approach in this situation. Physicians, when compared to other team members, are more likely to provide a specific recommendation vs. to present the information and let the family decide (odds ratio (95% confidence interval)=4.0 (1.2-12.8), p=0.021). A shared decision-making model, stressing our moral obligation as clinicians to respect autonomy by appreciating family values while offering to participate in the decision-making process and ensuring non-maleficence, is presented. In summary, CFTR modulators affect the outcomes of CF disease and influence clinical decision-making. Current lack of data on long-term outcomes, in young patients with CF receiving effective modulator therapy, should not preclude CF team participation in decision-making. Shared decision-making which is focused on respecting autonomy is our preferred approach in these situations.
Published: 2022

5. Beyond Frontline Therapy with Abiraterone and Enzalutamide in Metastatic Castration-Resistant Prostate Cancer: A Real-World US Study

Author: Neal D. Shore, Louise Yu, Dominique Lejeune, S. Ghate, François Laliberté, Jeri Kim, Lingfeng Yang, Mei Sheng Duh, Malena Mahendran, and Raluca Ionescu-Ittu
Subjects: Adult, Male, Oncology, medicine.medical_specialty, Urology, Population, Abiraterone Acetate, chemistry.chemical_compound, Prostate cancer, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Nitriles, Phenylthiohydantoin, medicine, Overall survival, Humans, Enzalutamide, education, Aged, Retrospective Studies, education.field_of_study, business.industry, medicine.disease, Prostatic Neoplasms, Castration-Resistant, Abiraterone, Treatment Outcome, Docetaxel, chemistry, Benzamides, Cohort, Adenocarcinoma, Androstenes, business, medicine.drug
Abstract: Background Real-world evidence suggest that next generation hormonal agents (NHAs) abiraterone and enzalutamide were preferred as first-line (1L) therapies for metastatic castration-resistant prostate cancer (mCRPC) in the United States (US) pre-2020, with chemotherapies, particularly docetaxel, being preferred in subsequent lines (2L+). This real-world study described patient characteristics, treatment patterns, time on treatment (ToT) and overall survival (OS) among patients with mCRPC treated with 2L and 3L docetaxel post-NHAs in the mCRPC setting. Methods Adults with confirmed adenocarcinoma mCRPC diagnosis and ≥1 month of follow-up post-diagnosis were selected from a US electronic health record-derived oncology de-identified database (01/2013–03/2019). Based on the observed line of therapy sequences post-mCRPC diagnosis, patients who received NHA therapy in 1L and docetaxel therapy in 2L were included in the 2L docetaxel cohort, and patients who received NHA therapy in both 1L and 2L and docetaxel therapy in 3L were included in the 3L docetaxel cohort. ToT and OS were evaluated using Kaplan-Meier analysis. Results Among 5,213 patients with mCRPC, 278 and 166 were included in the 2L and the 3L docetaxel cohorts, respectively (median age: 73 years for both cohorts). ADT was the most used class of medication pre-mCRPC (>75%). For the 2L cohort, the most common sequence post-mCRPC was 1L abiraterone → 2L docetaxel (52.5%), while the median ToT and OS post-2L start were 4.1 and 10.5 months, respectively; for the 3L cohort, the most common sequence post-mCRPC was 1L abiraterone → 2L enzalutamide → 3L docetaxel (67.5%), while the median ToT and OS post-3L start were 3.8 and 8.7 months, respectively. Conclusions This real-world study provides novel data on patients treated with docetaxel post-NHAs in a mCRPC setting and highlights the critical unmet need for developing more effective treatment options in this population.
Published: 2021

6. Fertility and Pregnancy in Cystic Fibrosis

Author: Isabelle Durieu, Malena Cohen-Cymberknoh, Jennifer L. Taylor-Cousar, and Michal Shteinberg
Subjects: Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Cystic Fibrosis, Pregnancy Rate, Reproductive Techniques, Assisted, medicine.medical_treatment, media_common.quotation_subject, Cystic fibrosis-related diabetes, Genetic Counseling, Fertility, Reproductive technology, Critical Care and Intensive Care Medicine, Risk Assessment, Cystic fibrosis, Ivacaftor, Pregnancy, medicine, Humans, Lactation, Genetic Testing, Chloride Channel Agonists, Reproductive health, media_common, Assisted reproductive technology, business.industry, Obstetrics, Pregnancy Outcome, medicine.disease, Respiratory Function Tests, Pregnancy Complications, Infertility, Female, Preconception Care, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: People with cystic fibrosis (pwCF) have experienced increased survival and wellbeing in recent decades, such that more than half of those living with CF are adults. Consequently, sexual and reproductive health is increasingly important for pwCF, because many are considering parenthood. Most men and some women with CF (wwCF) will have reduced fertility, which in both sexes is multifactorial. However, unplanned pregnancies in women are not rare, and contraception and its interaction with CF complications need to be addressed by the CF team. Reduced fertility may be overcome in most pwCF through use of assisted reproductive technologies; however, the risk of having offspring with CF must be considered. Most wwCF will have normal pregnancies, but premature birth is common, especially in the setting of reduced lung function and CF-related diabetes (CFRD); optimization of treatment is recommended during pregnancy planning. Parenting imposes an increased burden on pwCF, with the challenges of caring for the newborn, postpartum physiologic changes, and maintaining CF treatments. Most drugs used to treat CF are considered safe in pregnancy and lactation, but exceptions need to be acknowledged, including the limited data regarding safety of CF transmembrane conductance regulator (CFTR) modulators during conception, pregnancy, and lactation. Because most pwCF are eligible for highly effective CFTR modulators, fertility, contraception, and pregnancy in people with CF is changing. Prospective studies regarding these issues in people treated with CFTR modulators are paramount to provide evidence-based guidance for management in the current era of CF care.
Published: 2021

7. Management of prediabetes from the perspective of Spanish physicians and community pharmacists: Detecta2 study

Author: Hector David de Paz, Mariona Lería Gelabert, Patricia Rodríguez-Fortúnez, Josep Franch-Nadal, Malena Melogno Klinkas, José A Fornos, Luis Lizán, and Marta Rodríguez de Miguel
Subjects: medicine.medical_specialty, Cross-sectional study, Endocrinology, Diabetes and Metabolism, education, 030209 endocrinology & metabolism, Pharmacists, Prediabetic State, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Physicians, medicine, Diabetes Mellitus, Humans, Routine clinical practice, 030212 general & internal medicine, Prediabetes, Nutrition and Dietetics, business.industry, medicine.disease, Clinical Practice, Cross-Sectional Studies, Family medicine, Observational study, business, Patient education
Abstract: Prediabetes is a high-risk state for diabetes. The study aims to describe routine clinical practice and the views of physicians and pharmacists on prediabetes management.An observational, descriptive, cross-sectional study was conducted using a structured questionnaire.A total of 410 physicians and 393 pharmacists completed the questionnaire. Self-adherence to clinical practice guidelines (CPGs) was reported by 51.5% and 23.2% of physicians and pharmacists, respectively. Less than 60% of participants defined prediabetes according to main CPG. Regarding the use of screening strategies to detect prediabetes (physicians: 96%; pharmacists: 42.1%), reports indicate the opportunistic strategy is widely employed (≥75%) whereas systematic screening is unusual (20%). Changes in lifestyle were deemed essential by almost all participants (≥95%), but in clinical practice only 58.3% of healthcare centers and 28.0% of pharmacies were found to provide awareness-raising/instruction. The role of pharmacists in the prevention of prediabetes/diabetes was judged useful by most participants.Use of CPG, systematic prediabetes screening strategies, and specific strategies for patient education are scarce. The support of community pharmacists in prediabetes management was well valued. Therefore, it is crucial that the lines of action followed by both physicians and pharmacists align with each other and with the CPG.
Published: 2021

8. Photoprotective activity of a cream containing lyophilized aqueous extract of Lepidium meyenii (MACA) against ultraviolet irradiation on mouse skin

Author: Malena, Castañeda-Alarcón, Carlos, Bell-Cortez, Julio, Hidalgo-Ascensios, and Luis, Moreno-Exebio
Subjects: protectores solares, Medicine (General), lepidium, Ultraviolet Rays, Water, efectos de la radiación, Mice, R5-920, Animals, Medicine, factor de protección solar, fitoterapia, Sun Protection Factor, Sunscreening Agents
Abstract: To evaluate the photoprotective activity of a cream with lyophilized aqueous extract of maca (LEM) against ultraviolet (UV) irradiation in the skin of mice.An experimental study was carried out on 35 BALB/c mice. Treatment was applied topically on the dorsum of the animals, which were subsequently irradiated with ultraviolet B rays, and then we measured the thickness in microns (μm) of histological samples of the skin of the mice. Seven groups were assigned, divided into non-irradiated: Blank (G1) and irradiated with UV light: no treatment (G2); with commercial sunscreen with sun protection factor (SPF) 30 (G3); cream (placebo) (G4); LEM at 15% in water (G5); LEM cream at 5% (G6); and LEM cream at 15% (G7). In vitro SPF was determined using the Mansur method. Absorbance readings were taken in an ultraviolet- visible spectrophotometer (UV-VIS) and SPFs were determined for the following formulations: LEM cream at 5%, benzophenone-4 (BZF-4) and commercial sunscreen SPF 30.Mouse skin thickness in microns (μm) was 27.28 in G2; 18.31 in G3; 27.33 in G4; 19.51 in G5 and 18.04 in G6. There was no significant difference between the group not exposed to radiation (G1) and the 15% LEM cream group (G7), both had the lowest thicknesses (12.76 and 14.20 μm, respectively). The SPF of LEM cream at 15% was 5.480 ± 0.020.The formulation with LEM cream showed photoprotective activity against UV irradiation, alkaloids were the phytochemical components mostly found and the formulation was compatible with the active principle (LEM).Evaluar la actividad fotoprotectora de una crema con extracto acuoso liofilizado de maca (ELM) frente a la irradiación ultravioleta (UV) en la piel de ratones.Se realizó un estudio experimental en 35 ratones BALB/c. Los tratamientos fueron aplicados por vía tópica en el dorso de los animales y posteriormente irradiados con rayos ultravioleta B, para luego medir el grosor en micras (µm) de muestras histológicas de la piel de los ratones. Se asignaron siete grupos divididos en no irradiado: blanco (G1) e irradiados con luz UV: sin tratamiento (G2); con protector solar comercial con factor de protección solar (FPS) 30 (G3); crema (placebo) (G4); ELM al 15% en agua (G5); ELM al 5% en crema (G6); y ELM al 15% en crema (G7). Se determinó el FPS in vitro, mediante el método de Mansur. Se realizaron las lecturas de las absorbancias en un espectrofotómetro ultravioleta-visible (UV-VIS) y se determinaron los FPS para las siguientes formulaciones: ELM al 5% en crema, benzofenona-4 (BZF-4) y bloqueador solar comercial FPS 30.El grosor de piel de ratón en micras (µm) fue de 27,28 en G2; 18,31 en G3; 27,33 en G4; 19,51 en G5 y 18,04 en G6; no hubo diferencia significativa entre el grupo no expuesto a la radiación (G1) y el grupo ELM al 15% en crema (G7), ambos presentaron los menores grosores (12,76 y 14,20 µm, respectivamente). El FPS de ELM al 15% en crema fue 5,480 ± 0,020.La formulación con ELM en crema presentó actividad fotoprotectora frente a la irradiación UV, los alcaloides fueron los componentes fitoquímicos mayormente encontrados y la formulación fue compatible con el activo (ELM).
Published: 2021

9. Clinical-Laboratory Profile of Child and Young Populations Bit By Scorpion Attended at a Information and Assistance Toxicological Center in Brazil

Author: Sarah Gabrielle Sousa de Oliveira Rodrigues, Andreza da Silva Soares Pereira, Geraldo Bezerra da Silva Junior, Edilson Martins Rodrigues Neto, Fernanda Maria Teófilo Campos, Elizabeth De Francesco Daher, Malena Gadelha Cavalcante, João Augusto Lima Bisneto, and Naiane Nadylla Nobre Sombra
Subjects: medicine.medical_specialty, Pediatrics, education.field_of_study, biology, business.industry, Public health, Population, Scorpion, biology.animal, Epidemiology, medicine, Observational study, Leukocytosis, General Pharmacology, Toxicology and Pharmaceutics, medicine.symptom, education, business, Bit (key)
Abstract: Background: In Brazil, the most relevant scorpions for public health are species of the genus Tityus: T. serrulatus, T. bahiensis, T. obscurus and T. stigmurus, the latter occurring mainly in Ceara, showing that severe cases affect more the population at risk, children under 14 years old. Objectives: The survey aims to identify what are the clinical and laboratory changes in children and teenagers affected by scorpion bites, as well as predictive factors in severe cases. Methods: This is an observational, retrospective and quantitative study of poisoning by scorpion accidents attended and notified by the Toxicological Assistance Center of Fortaleza (CIATOX / CE) from January to December 2019. Results: 820 records were diverted, in which 425 (51.83%) women were killed, of which only 3 (0.37%) were pregnant. Regarding the age group, 1-3 years old is more frequent, 183 (22.32%). The species T. stigmurus 534 cases, (65.12%), the feet region 271 cases (33.04%); the origin of the municipality of Fortaleza 773 (94.15%) and the regional II 122 cases (15.78%) had higher occurrences. Of the 820 cases, only 12 underwent laboratory tests, showing changes such as leukocytosis leukocytosis (72.7%), platelets (63.6%), hyperglycemia (83.3%), TGO (100%), LDH (100%), CK - MB (100%) and Amylase (30%). Conclusion: It was found that the epidemiological, clinical and laboratory profile of children and adolescentes is associated with the severity of scorpionism, which indicates an emergency characteristic, especially when it affects children. Keywords: Scorpions, Clinic Epidemiology, Intoxications, Children and youth, Tityus.
Published: 2021

10. A rare canonical splice-site variant in VPS13B causes attenuated Cohen syndrome

Author: Fabiana Louise Motta, Malena Daich Varela, Gavin Arno, and Andrew R. Webster
Subjects: Male, medicine.medical_specialty, Visual acuity, genetic structures, Developmental Disabilities, Vesicular Transport Proteins, Fundus (eye), Fingers, Exon, Intellectual Disability, Ophthalmology, Retinal Dystrophies, Electroretinography, Myopia, medicine, Humans, Obesity, Scotopic vision, Genetics (clinical), Cohen syndrome, business.industry, Retinal Degeneration, medicine.disease, eye diseases, VPS13B, Diabetes Mellitus, Type 2, Pediatrics, Perinatology and Child Health, Microcephaly, Muscle Hypotonia, sense organs, medicine.symptom, business, Erg, Tomography, Optical Coherence, Photopic vision
Abstract: Background To describe a patient with a history of obesity, retinal dystrophy, type II diabetes, and mild cognitive impairment; found to harbour biallelic splice-site variants in VPS13B. Materials & methods A complete ophthalmic evaluation was performed at Moorfields Eye Hospital (London, United Kingdom), consisting of measurement of best-corrected visual acuity (BCVA), slit lamp and dilated fundus evaluation, colour, autofluorescence and near-infrared retinal imaging, spectral domain-optical coherence tomography, and electroretinogram (ERG). Whole-genome sequencing was performed as part of the UK's 100,000 Genomes Project. Results A 26-year-old Pakistani man with normal appearance, stature, and head size presented with decreased BCVA and severely constricted visual fields to our Ophthalmic Genetics clinic. He had a history of obesity, type II diabetes, and mild cognitive impairment. His evaluation showed retina-wide, severe photoreceptor dysfunction in both eyes, with undetectable scotopic and photopic ERG waveforms. Genomic analysis identified a homozygous rare splice donor variant in the VPS13B gene (c.5024+2T>C) that was demonstrated to lead to skipping of the in-frame exon 31 (p.Gln1607_Ser1675delinsHis). Conclusions Exon 31 skipping in VPS13B may lead to a hypomorphic change, with partial gene function and an incomplete, mild Cohen syndrome-like phenotype.
Published: 2021

11. Real-world genetic testing patterns in metastatic castration-resistant prostate cancer

Author: Dominique Lejeune, François Laliberté, Louise Yu, Lingfeng Yang, Mei Sheng Duh, Malena Mahendran, Neal D. Shore, Raluca Ionescu-Ittu, S. Ghate, and J. Burgents
Subjects: Male, Oncology, Cancer Research, medicine.medical_specialty, DNA Repair, PALB2, Clinical Decision-Making, Cancer Care Facilities, Poly(ADP-ribose) Polymerase Inhibitors, Castration resistant, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Internal medicine, FANCA gene, Biomarkers, Tumor, medicine, Humans, In patient, Genetic Testing, 030212 general & internal medicine, Practice Patterns, Physicians', Precision Medicine, Aged, Genetic testing, Aged, 80 and over, Academic Medical Centers, medicine.diagnostic_test, business.industry, Medical record, Hazard ratio, Community Health Centers, General Medicine, Middle Aged, medicine.disease, Prostatic Neoplasms, Castration-Resistant, 030220 oncology & carcinogenesis, business
Abstract: Aim: To assess the patterns of genetic testing for homologous recombination repair mutations in patients with metastatic castration-resistant prostate cancer (mCRPC) pre-PARP inhibitors approval. Patients & methods: mCRPC patients were selected in an oncology electronic medical records database. Patterns and predictors of testing for ATM, BRCA1/2, CDK12, PALB2 and FANCA gene alterations were assessed. Results: Of 5213 mCRPC patients, 674 (13%) had a documented genetic test. The number of tested patients increased from 1 in 2013 to 313 in 2018 (out of 3161 and 3010 clinically active patients, respectively). Receiving care in an academic oncology center (versus a community-based center) strongly predicted genetic testing (hazard ratio = 2.41). Conclusion: The use of and access to genetic testing pre-PARP inhibitor approval was suboptimal.
Published: 2021

12. Real-World Treatment Patterns and Overall Survival of Patients with Metastatic Castration-Resistant Prostate Cancer in the US Prior to PARP Inhibitors

Author: Mei Sheng Duh, J. Burgents, François Laliberté, Malena Mahendran, Lingfeng Yang, S. Ghate, Louise H. Yu, Raluca Ionescu-Ittu, Dominique Lejeune, and Neal D. Shore
Subjects: Male, Time on treatment, Oncology, medicine.medical_specialty, Next-generation hormonal agents, medicine.medical_treatment, Kaplan-Meier Estimate, Poly(ADP-ribose) Polymerase Inhibitors, Castration resistant, Treatment duration, Prostate cancer, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Overall survival, Chemotherapy, Humans, Medicine, Pharmacology (medical), Electronic medical records, Original Research, Lines of therapy, Aged, Retrospective Studies, business.industry, General Medicine, medicine.disease, Rheumatology, Prostatic Neoplasms, Castration-Resistant, Increased risk, Adenocarcinoma, business
Abstract: Introduction Therapeutic options for metastatic castration-resistant prostate cancer (mCRPC) patients are continuously advancing. We described mCRPC treatment patterns in the US from 2013 to 2019. Methods Patients with a confirmed mCRPC diagnosis and adenocarcinoma histology were included in the US Flatiron Health Electronic Health Record-derived de-identified database. Treatment patterns [including treatment per lines of therapies (LOTs), LOT sequences, and time on treatment] and overall survival (OS) have been described in mCRPC settings. Results Of 5213 patients (mean age: 72.6 years), 4374 (83.9%) were treated with ≥ 1 LOT post-mCRPC diagnosis (among those with ≥ 1 LOT, 55.3%, 29.5%, 14.7%, and 6.7% had ≥ 2, 3, 4, and 5 LOTs, respectively). In first line (1L), the main treatment class was next-generation hormonal agents (NHA; 62.5% of patients with ≥ 1 LOT), while the shortest and longest time on 1L were observed for chemotherapy (median 2.8 months) and NHA (median 5.1 months), respectively. The most common LOT sequences were NHA → NHA (29.4% of patients with ≥ 2 LOTs) and NHA → NHA → chemotherapy (16.7% of patients with ≥ 3 LOTs). In Kaplan–Meier analyses, the median OS was 19.4, 14.6, and 11.1 months post-1L, 2L, and 3L start, respectively. Patients who moved rapidly through LOTs had an increased risk of death. Conclusions NHA were widely used as 1L therapy in mCRPC patients from 2013 to 2019, but time on 1L NHA treatment was on average
Published: 2021

13. Características clínicas y microbiológicas de infecciones del torrente sanguíneo en pacientes adultos neutropénicos

Author: Sofía Mariela Vázquez, Agustín Toranzo, María Aldana Cometto, Juan Pablo Caeiro, María Victoria Díaz, Emanuel José Saad, Malena Finello, David Francisco Suasnabar, Mercedes de Jesús García, Luis Richetta, Daniela Hernández, and Jeremías Sierra
Subjects: Microbiology (medical), 0303 health sciences, medicine.medical_specialty, biology, 030306 microbiology, business.industry, Klebsiella pneumoniae, Antimicrobial susceptibility, Cancer, Retrospective cohort study, General Medicine, Neutropenia, medicine.disease_cause, medicine.disease, biology.organism_classification, Microbiology, Gastroenterology, 03 medical and health sciences, Staphylococcus aureus, Bacteremia, Internal medicine, Medicine, business, Gram-Positive Cocci
Abstract: Bloodstream infections (BI) are relevant in neutropenic patients because they are associated with an increased number of complications and death. The objective was determinate the epidemiologic and microbiologic features of the BI in neutropenic patients with solid neoplasm (SN) and hematologic neoplasm (HN). Retrospective study in two third level hospitals between 2009 and 2016. They were included all the patients older than 18 years-old with active oncologic disease and neutropenia, who had BI. Patients with dermatologic cancer other than melanoma where excluded. A total of 143 BI in neutropenic were observed, of which 80.4% occurred in HN. Around 97.9% of the patients had a high-risk neutropenia without differences between both groups. The most frequent site of BI was primary bacteremia (46.9%) and catheter-associated infection (21%), without significant differences between the two groups. The gram negatives bacilli (GNB) predominated over the gram positive cocci (GPC) and they represented 74.1% of the isolated bacteria, being Escherichia coli the most frequent (32.8%). Among the gram positive cocci, Staphylococcus aureus (28.1%) was the most frequent isolated, followed by coagulase-negative Staphylococci (CNS). There were no differences in microbiological isolates between both groups. With regard to the antimicrobial susceptibility 67.5% of the CNS, 17.6% of the E. coli and 27.6% of the Klebsiella pneumoniae were multiresistant with no differences between both groups. Only 11.1% of S. aureus isolates were methicillin resistant. In conclusion BI of the neutropenic patients where most frequents within patients with HN, GNB were the main microbiological isolates. High mortality was observed in neutropenic patients with BI.
Published: 2021

14. Real-World Healthcare Resource Utilization (HRU) and Costs of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Receiving Eculizumab in a US Population

Author: Wendy Y. Cheng, S. Krishnan, Nikita Mody-Patel, Mei Sheng Duh, Dominique Lejeune, Louise H. Yu, Malena Mahendran, Mihran Ara Yenikomshian, and Sujata P. Sarda
Subjects: Adult, Male, medicine.medical_specialty, Blood transfusion, Databases, Factual, medicine.medical_treatment, Population, Hemoglobinuria, Paroxysmal, Economic burden, Antibodies, Monoclonal, Humanized, Internal medicine, Healthcare resource utilization, Absenteeism, medicine, Humans, Pharmacology (medical), Paroxysmal nocturnal hemoglobinuria, education, Original Research, Treatment patterns, education.field_of_study, business.industry, Retrospective cohort study, General Medicine, Eculizumab, Patient Acceptance of Health Care, medicine.disease, Rheumatology, Discontinuation, Medical costs, Retrospective study, Cohort, Female, business, medicine.drug
Abstract: Introduction To evaluate the economic burden and treatment patterns of patients with paroxysmal nocturnal hemoglobinuria (PNH) treated with eculizumab, a C5 inhibitor, who were defined as blood transfusion-dependent (TD) versus blood transfusion-free (TF) in the US population. Methods Patients aged at least 12 years with at least two claims for eculizumab infusion (first claim was the index date) were identified from the IBM® MarketScan® Research Databases (April 1, 2014–September 30, 2019). The overall PNH eculizumab user cohort was stratified into the TD cohort (i.e., at least one claim for blood transfusion within 6 months following any eculizumab infusion, including on the infusion date) or the TF cohort (i.e., all non-TD patients). Treatment patterns, healthcare resource utilization (HRU), and costs were evaluated and compared during follow-up (i.e., index date to end of enrollment or data availability). Results Of 151 patients in the overall cohort (mean age 36.7 years; 55.6% female), 55 were TD (mean age 35.1 years; 67.3% female) and 96 were TF (mean age 37.6 years; 49.0% female). A total of 61% of patients (TD, 66%; TF, 58%) discontinued eculizumab, with TD patients having a shorter median time to discontinuation (TD, 0.5 years; TF, 0.9 years). TD patients had more all-cause hospitalizations than TF patients (p
Published: 2021

15. Myositis-specific antibodies and clinical characteristics in patients with autoimmune inflammatory myopathies: reported by the Argentine Registry of Inflammatory Myopathies of the Argentine Society of Rheumatology

Author: Boris Kisluk, Mariana Aciar, Ramiro Gomez, Mercedes A. García, Mariano Rivero, Dafne Capelusnik, A. C. Costi, Nicolás Pérez, María N Lojo, Andrea Braillard Poccard, M. Cosatti, Belen I Barrios, María Elena Crespo Espindola, Alejandro Benitez, Malena Viola, Cecilia Pisoni, Amelia Granel, Graciela Gómez, and Demelza Yucra
Subjects: 030203 arthritis & rheumatology, medicine.medical_specialty, business.industry, Interstitial lung disease, Cancer, Arthritis, General Medicine, Dermatomyositis, medicine.disease, Gastroenterology, Polymyositis, Rheumatology, Serology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, 030212 general & internal medicine, Inclusion body myositis, business
Abstract: To describe clinical features in patients with inflammatory myopathies (IMs) from the Argentine Registry of Inflammatory Myopathies, and their relationship with myositis-specific antibodies (MSAs). This cross-sectional study included 360 adult patients with dermatomyositis (DM), polymyositis (PM), and inclusion body myositis. Demographics, clinical, and serological characteristics were retrospectively recorded (2016–2019). MSAs were determined by immunoblotting. Patients who were positive for anti-Jo-1, Mi-2, and MDA5 were compared against a group of patients, taken as reference group, who were negative for all MSAs. Women 72%, median age at diagnosis was 47.3 years (18–82). The most frequent subtypes were DM (43.9%) followed by PM (30%).The most frequent MSAs were anti-Jo-1 (51/317), 16.1%; MDA5 (12/111), 10.8%, and Mi-2 (23/226), 10.2%. Anti-Jo-1 was associated (p
Published: 2021

16. Elevated Testosterone Level and Urine Scent Marking in Male 5xFAD Alzheimer Model Mice

Author: Kristina Endres, Jakob Winkler, Tobias Hartmann, Marcus O. W. Grimm, Lisa Gadomsky, Michael A. van der Kooij, and Malena dos Santos Guilherme
Subjects: Male, 0301 basic medicine, medicine.medical_specialty, mice, Amyloid beta, Central nervous system, Mice, Transgenic, amyloid precursor protein, Amyloid beta-Protein Precursor, Sexual Behavior, Animal, 03 medical and health sciences, 0302 clinical medicine, sexual behavior, Alzheimer Disease, Internal medicine, Testis, Presenilin-1, medicine, Amyloid precursor protein, Animals, Sperm Count, biology, Wild type, Brain, Organ Size, Alzheimer's disease, Sertoli cell, Sperm, Phenotype, Androgen receptor, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Neurology, testosterone, biology.protein, Neurology (clinical), 030217 neurology & neurosurgery, urine scent marking test
Abstract: Background:Function of the Amyloid Precursor Protein (AβPP) and its various cleavage products still is not unraveled down to the last detail. While its role as a source of the neurotoxic Amyloid beta (Aβ) peptides in Alzheimer’s Disease (AD) is undisputed and its property as a cell attachment protein is intriguing, while functions outside the neuronal context are scarcely investigated. This is particularly noteworthy because AβPP has a ubiquitous expression profile and its longer isoforms, AβPP750 and 770, are found in various tissues outside the brain and in non-neuronal cells.Objective:Here, we aimed at analyzing the 5xFAD Alzheimer’s disease mouse model in regard to male sexual function. The transgenes of this mouse model are regulated by Thy1 promoter activity and Thy1 is expressed in testes, e.g. by Sertoli cells. This allows speculation about an influence on sexual behavior.Methods:We analyzed morphological as well as biochemical properties of testicular tissue from 5xFAD mice and wild type littermates and testosterone levels in serum, testes and the brain. Sexual behavior was assessed by a urine scent marking test at different ages for both groups.Results:While sperm number, testes weight and morphological phenotypes of sperms were nearly indistinguishable from those of wild type littermates, testicular testosterone levels were significantly increased in the AD model mice. This was accompanied by elevated and prolonged sexual interest as displayed within the urine scent marking test.Conclusion:We suggest that overexpression of AβPP, which mostly is used to mimic AD in model mice, also affects male sexual behavior as assessed additional by the Urine Scent Marking (USM) test. The elevated testosterone levels might have an additional impact on central nervous system androgen receptors and also have to be considered when assessing learning and memory capabilities.
Published: 2022
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17. Sleep in children with cystic fibrosis: More under the covers

Author: Alex Gileles-Hillel, Malena Cohen-Cymberknoh, Erick Forno, Joel Reiter, and Oded Breuer
Subjects: Sleep Wake Disorders, Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Cystic Fibrosis, Cystic fibrosis, Hypoxemia, 03 medical and health sciences, Sleep Apnea Syndromes, 0302 clinical medicine, 030225 pediatrics, medicine, Humans, Respiratory system, Child, Hypoxia, Sleep quality, business.industry, medicine.disease, Sleep in non-human animals, Multisystem disease, 030228 respiratory system, Lung disease, Pediatrics, Perinatology and Child Health, Breathing, medicine.symptom, Sleep, business
Abstract: Cystic fibrosis (CF) is a chronic multisystem disease with manifestations from birth. It involves the entire respiratory system, with increased cough, and recurrent pulmonary infections, and it also leads to intestinal malabsorption, all of which can have an impact on sleep. In this review, we summarize the available literature on the various sleep disturbances in children with CF. Sleep quality and sleep efficiency are often impaired in children with CF. They may be accompanied by symptoms associated with sleep-disordered breathing (SDB), and objective findings such as nocturnal hypoxemia. Importantly, a strong association has been shown between SDB and the severity of lung disease, and some studies have reported a similar association for sleep quality. Further research is needed to better characterize the association of sleep disturbances with respiratory outcomes and the impact of treatment of sleep disorders on pulmonary status in children with CF. This article is protected by copyright. All rights reserved.
Published: 2021

18. A new reliable and highly specific monoclonal antibody to detect the C‐terminal region of silencer of cytokine signaling 1

Author: Stephanie E. Weissinger, Peter Möller, Gerhard Moldenhauer, Claudia Tessmer, Ralf Marienfeld, and Malena Zahn
Subjects: Lymphoma, B-Cell, Lymphoma, Lymphoid Tissue, medicine.drug_class, Palatine Tonsil, Transfection, Monoclonal antibody, Epitopes, Mice, 03 medical and health sciences, Suppressor of Cytokine Signaling 1 Protein, 0302 clinical medicine, Protein Domains, Affinity chromatography, medicine, Animals, Humans, B-cell lymphoma, Mice, Inbred BALB C, Binding Sites, Hybridomas, biology, Antibodies, Monoclonal, Hematology, General Medicine, medicine.disease, Molecular biology, HEK293 Cells, Epitope mapping, 030220 oncology & carcinogenesis, Mutation, Monoclonal, biology.protein, Immunohistochemistry, Antibody, Epitope Mapping, Signal Transduction, 030215 immunology
Abstract: Introduction SOCS1, a negative regulator of JAK/STAT signaling, is among the most frequently mutated genes in DLBCL and classical Hodgkin lymphoma. The C-terminal SOCS box domain, mediating the degradation of phospho-JAK2, is often affected or even lacking. The analysis of such variants is hampered by the lack of a SOCS1-specific monoclonal antibody recognizing the C-terminus of SOCS1. As this C-terminus is often lost or mutated in B-cell lymphomas, staining with amino-terminal targeting antibodies in a lymphoma setting might be misleading. Methods BALB/c mice were immunized with a truncated SOCS1 C-terminal protein. The supernatant of generated hybridoma cells was screened by ELISA and, immunohistochemically, on formalin-fixed and paraffin-embedded tonsil. After antibody purification by affinity chromatography, epitope mapping and cross-reactivity check followed via substitution scans. SOCS1 protein expression was investigated on cell cultures and cytoblocks of SOCS1WT stably transfected HEK293T cells, lymphoma cell lines and lymphoid tissues. Results Procedures resulted in one monoclonal IgG1 anti-SOCS1 antibody, 424C, that recognizes and strongly binds to the C-terminal region of SOCS1 in immunoblot and immunohistochemistry analyses. Conclusion This new anti-SOCS1 monoclonal antibody is a valuable tool to detect SOCS1 expression dependent on an existing SOCS1 box and, therefore, indicating a full-length SOCS1 protein.
Published: 2021

19. Baseline Cystic fibrosis disease severity has an adverse impact on pregnancy and infant outcomes, but does not impact disease progression

Author: Micha Aviram, Huda Mussaffi, Elie Picard, Eitan Kerem, Drorith Hochner Celnikier, Bar Gindi Reiss, Javier Miranda, Hannah Blau, Noah Lechtzin, Hagai Amsalem, Joel Melo, Michal Shteinberg, Gema Pérez, Inbal Golan Tripto, Stefano Aliberti, Hagit Levine, Malena Cohen-Cymberknoh, Michal Gur, Joel Reiter, Lea Bentur, Galit Livnat, Francesco Blasi, Eva Polverino, and Michal Novoselsky
Subjects: Adult, 0301 basic medicine, Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Adolescent, Cystic Fibrosis, media_common.quotation_subject, Fertility, Disease, Severity of Illness Index, Cystic fibrosis, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Pregnancy, medicine, Humans, Pseudomonas Infections, Retrospective Studies, media_common, business.industry, Infant, Newborn, Pregnancy Outcome, Middle Aged, Prognosis, medicine.disease, Respiratory Function Tests, Pregnancy Complications, 030104 developmental biology, 030228 respiratory system, Pediatrics, Perinatology and Child Health, Disease Progression, Small for gestational age, Female, business, Infertility, Female, Body mass index, Cohort study
Abstract: Background With increasing longevity and quality of life in adults with Cystic fibrosis (CF), growing maternity rates are reported. Women with severe CF are becoming pregnant, with unpredictable maternal and fetal outcomes. Aim To determine how baseline disease severity, pancreatic insufficiency (PI) and Pseudomonas aeruginosa (PA) infection affect fertility, the pregnancy course, delivery, neonatal outcome, and subsequent disease progression. Methods A multicenter-retrospective cohort study. Data on patients that had been pregnant between 1986-2018 was collected from ten CF centers worldwide. Disease severity [mild or moderate-severe (mod-sev)] was defined according to forced expiratory volume % predicted in 1 second (FEV1) and body mass index (BMI). Three time periods were compared, 12 months prior to conception, the pregnancy itself and the 12 months thereafter. Results Data was available on 171 pregnancies in 128 patients aged 18-45 years; 55.1% with mod-sev disease, 43.1% with PI and 40.3% with PA. Women with mod-sev disease had more CF-related complications during and after pregnancy and delivered more preterm newborns. However, FEV1 and BMI decline were no different between the mild and mod-sev groups. A more rapid decline in FEV1 was observed during pregnancy in PI and PA infected patients, though stabilizing thereafter. PI was associated with increased risk for small for gestational age infants. Conclusion Baseline disease severity, PA infection and PI have an adverse impact on infant outcomes, but do not impact significantly on disease progression during and after pregnancy. Consequently, pregnancies in severe CF patients can have a good prognosis.
Published: 2021

20. Perfil Epidemiológico dos óbitos acumulados por COVID-19 em 2020, Piaui, Brasil / Epidemiological profile of deaths from COVID-19 in 2020, Piaui, Brazil

Author: Maria Amélia de Oliveira Costa, Jossuely Rocha Mendes, Dilia Sávia de Sousa Falcão, Ester Miranda Pereira, Adalberto Socorro da Silva, Malena Gonçalves Almeida, Bárbara Sandra Pinheiro dos Santos, and Deylane Menezes Teles e Oliveira
Subjects: Marketing, Pharmacology, Organizational Behavior and Human Resource Management, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Strategy and Management, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pharmaceutical Science, Retrospective cohort study, Disease control, Age groups, Environmental health, Drug Discovery, Epidemiology, Medicine, business
Abstract: Introduction: Caused by SARS-CoV-2, COVID-19 generates respiratory infections ranging from asymptomatic to severe and lethal forms. In the state of Piaui, the first confirmed case and the first death occurred in March, and since then the State has sought to increase strategic plans in order to avoid an increase in mortality, with the aim of the present study to analyze the epidemiological profile of deaths by COVID-19 in Piaui. Method: This is a retrospective observational study on the epidemiological profile of cases of death from COVID-19 in the State of Piaui until the end of December 2020. Results: At the end of 2020, Piaui registered a total of 2,841 accumulated deaths, the majority of which were reported in people of the male sex, with a predominance among the 61 to 80 age groups. 87.35% of these cases had comorbidities, mostly arterial hypertension or cardiovascular diseases. Implications: The state of Piaui demonstrates an epidemiological profile of its deaths similar to other cities, but this is not synonymous with disease control. Public policies must continue and measures must be intensified to avoid aggravating the situation.
Published: 2021

21. How abnormal is the normal? Clinical characteristics of CF patients with normal FEV 1

Author: Reuven Tsabari, Eitan Kerem, angeles spangenberg, Oded Breuer, I. Eisenstadt, Malena Cohen-Cymberknoh, David Shoseyov, Laura Garriga, Silvia Gartner, T. Israeli, Alex Gileles-Hillel, Natalia Simanovsky, Elad Ben Meir, and Joel Reiter
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Lung, medicine.drug_class, business.industry, Pseudomonas aeruginosa, Antibiotics, Lung Clearance Index, medicine.disease, medicine.disease_cause, Cystic fibrosis, Gastroenterology, medicine.anatomical_structure, Lung disease, Internal medicine, Pediatrics, Perinatology and Child Health, medicine, In patient, Respiratory system, business
Abstract: BACKGROUND Normal values (>80%) of Forced Expiratory Volume in one second (FEV1 ) in patients with cystic fibrosis (CF) may lead to the interpretation that there is no lung disease. This study is a comprehensive analysis of lung involvement in CF patients having normal FEV1 . METHODS Patients were recruited from two CF centers: Hadassah Medical Center, Jerusalem and Vall d' Hebron Hospital, Barcelona. Lung disease was assessed by lung clearance index (LCI), chest CT-Brody score, respiratory cultures, number of pulmonary exacerbations (PEx), and days of antibiotic treatment in the year before the assessment. RESULTS Of the 247 patients, 89 (36%) had FEV1 ≥80% and were included in the study (mean age, 17.6; range, 4.25-49 years). Chronic Pseudomonas aeruginosa infection was found in 21%, and 31% had at least one major PEx in the year before the study. Abnormally elevated LCI was found in 86% of patients, ranging between 7.52 and 18.97, and total Brody score (TBS) was abnormal in 92% (range, 5.0-96.5). Patients with chronic P. aeruginosa had significantly higher LCI (p = .01) and TBS (p = .02) which were associated with more major PEx (p
Published: 2021

22. Treatments for dry age-related macular degeneration: therapeutic avenues, clinical trials and future directions

Author: Michel Michaelides, Malena Daich Varela, Thales Antonio Cabral de Guimaraes, and Michalis Georgiou
Subjects: Vascular Endothelial Growth Factor A, Oncology, medicine.medical_specialty, genetic structures, Angiogenesis, Genetic enhancement, Visual Acuity, Angiogenesis Inhibitors, Neuroprotection, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Geographic Atrophy, Internal medicine, medicine, Humans, Dry age-related macular degeneration, 030304 developmental biology, 0303 health sciences, business.industry, Macular degeneration, medicine.disease, eye diseases, Sensory Systems, 3. Good health, Vascular endothelial growth factor, Clinical trial, Ophthalmology, chemistry, Wet Macular Degeneration, 030221 ophthalmology & optometry, sense organs, business, Early phase
Abstract: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the developed world. The identification of the central role of vascular endothelial growth factor (VEGF) in the pathogenesis of neovascular AMD and the introduction of anti-VEGF agents as gold-standard treatment, have drastically changed its prognosis—something yet to be seen in dry AMD. Several therapeutic avenues with a wide variability of targets are currently being investigated in dry AMD. The approaches being investigated to reduce the rate of disease progression include, (1) drugs with antioxidative properties, (2) inhibitors of the complement cascade, (3) neuroprotective agents, (4) visual cycle inhibitors, (5) gene therapy and (6) cell-based therapies. A number of early phase clinical trials have provided promising results, with many more ongoing and anticipated in the near future. In this review, we aim to provide an update of the interventional trials to date and future prospects for the treatment of dry AMD.
Published: 2021

23. Procrastinación, ansiedad ante los exámenes y rendimiento académico en estudiantes universitarios

Author: Federico Hervías Ortega and Malena Manchado Porras
Subjects: media_common.quotation_subject, 05 social sciences, Procrastination, 050109 social psychology, Cognition, Academic achievement, Affect (psychology), medicine.disease, 050105 experimental psychology, Negative relationship, medicine, Anxiety, 0501 psychology and cognitive sciences, medicine.symptom, Psychology, Psychosocial, General Psychology, Clinical psychology, media_common, Test anxiety
Abstract: Procrastination is defined as a behavioral tendency to postpone tasks that, because of their unmotivating or tedious characteristics, are not attractive to the performer, and whose delay can lead to negative consequences. This is the behavior of delaying responsibilities, being aware of their importance and the repercussions of the delay. These consequences can affect the personal, social, occupational and academic spheres of individuals. Therefore, the purpose of this study is to examine the relationship of academic procrastination and test anxiety on academic performance, as well as the relationship between the two variables. In this way, the aim is to achieve a better understanding of the links between the three variables, which will serve as a theoretical basis for preventing and intervening in the negative repercussions of procrastination. To this end, an investigation has been carried out with 201 college students, using the German Test Anxiety Inventory (GTAI-A), the Academic Procrastination Scale (EPA), and a record of the qualifications obtained by the participants collected through a self-report. This is a correlational design that does not include experimental manipulation of variables or randomization of the sample, so the aim is not to establish causal relationships but to determine the direction and strength of the associations between variables. The results reveal the presence of academic procrastination and test anxiety in university students. Specifically, the majority of participants (45.3 %) reflected a medium level of anxiety, 28.9 % reflected a high level and 25.9 % showed a low level. In the total sample, procrastination showed a mean score of 30.3 points out of 60. As for the relationships of both variables with academic performance, test anxiety shows a negative relationship with academic performance, so higher levels of anxiety are associated with worse grades. Procrastination does not show a significant and direct relationship with grades, but it is related to two anxiety factors (interference and lack of confidence), indirectly affecting academic performance. In addition, significant differences in academic performance have been found based on the different anxiety levels identified (χ 2 (2,201) = 16.929; p = .001 ), with the high anxiety group obtaining a lower mean score ( M = 5.74; SD = 1.27). This supports the hypothesis that test anxiety is negatively associated with academic performance. Moreover, it has been found that comparing the medium and low anxiety groups, the differences are not significant, but comparing each of them with the high anxiety group they are. Therefore, significant differences in the grades only appear when the level of anxiety is high. That is, a moderate level of anxiety is adaptive, and only becomes detrimental if it becomes high. In conclusion, to prevent and intervene in academic underachievement and associated psychosocial problems, university psychological services should consider the influence of test anxiety, procrastination and other cognitive, behavioral, motivational and emotional variables. According to this study, intervention in test anxiety is a central aspect, as it has a direct effect on academic performance. In the same way, procrastinating behaviors can be intervened, as they interfere indirectly in academic outcomes, being associated with cognitive manifestations of test anxiety. The relative weight of the different variables associated with academic achievement varies according to each student, so that an individualized approach to these types of problems would increase the levels of effectiveness and efficiency in the care provided by university psychological services. Finally, the need for more research to identify the factors associated with low academic performance and the relationships between them is highlighted, in order to facilitate the design of effective interventions for different student profiles. https://doi.org/10.16888/interd.2021.38.2.16
Published: 2021

24. Ivacaftor in People with Cystic Fibrosis and a 3849+10kb C→T or D1152H Residual Function Mutation

Author: Malena Cohen-Cymberknoh, Eitan Kerem, Michael Wilschanski, Alex Gileles-Hillel, Christopher Short, C DeSouza, Thea Pugatsch, Reuven Tsabari, Clare Saunders, Joel Reiter, James C. Sullivan, N. Kinnman, David Shoseyov, Jane C. Davies, Jamie R Doyle, and Keval Chandarana
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Respiratory System, rectal organoids, 1103 Clinical Sciences, medicine.disease, Gastroenterology, Cystic fibrosis, crossover studies, Ivacaftor, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Internal medicine, Mutation (genetic algorithm), medicine, Cyst, residual function mutations, 030212 general & internal medicine, business, medicine.drug
Abstract: Rationale: Ivacaftor's clinical effects in the residual function mutations 3849+10kb C →T and D1152H warrant further characterization. Objectives: Evaluate ivacaftor's effect in people with cystic fibrosis aged ≥6 years with 3849+10kb C→T or D1152H residual function mutations; explore the correlation between ivacaftor-induced organoid-based cystic fibrosis transmembrane conductance regulator function measurements and clinical response to ivacaftor. Methods: Participants were randomized (1:1) in this placebo-controlled crossover study; each treatment sequence included two 8-week treatments with an 8-week washout period. The primary endpoint was absolute change in lung clearance index2.5 from baseline through Week 8. Additional endpoints included lung function, patient-reported outcomes, and in vitro intestinal organoid-based measurements of ivacaftor-induced cystic fibrosis transmembrane conductance regulator function. Results: Of 38 participants, 37 completed the study. The primary endpoint was met; the Bayesian posterior probability of improvement in lung clearance index2.5 with ivacaftor vs placebo was >99%. Additional endpoints improved with ivacaftor. Safety findings were consistent with ivacaftor's known safety profile. Dose-dependent swelling was observed in 23/25 viable organoid cultures with ivacaftor treatment. Correlations between ivacaftor-induced organoid swelling and clinical endpoints were negligible to low. Conclusions: In people with cystic fibrosis aged ≥6 years with a 3849+10kb C →T or D1152H mutation, ivacaftor treatment improved clinical endpoints vs placebo; however, there was no correlation between organoid swelling and change in clinical endpoints. The organoid assay may assist in identification of ivacaftor-responsive mutations but in this study did not predict magnitude of clinical benefit for individual people with cystic fibrosis with these two mutations. Clinical trial registered with ClinicalTrials.gov (NCT03068312).
Published: 2021

25. Prophylactic strategies to control chikungunya virus infection

Author: Friederike I L Hucke, Joachim Jakob Bugert, and Malena Bestehorn-Willmann
Subjects: medicine.medical_specialty, Antiviral testing, Biology, medicine.disease_cause, Antiviral Agents, Arbovirus, Virus, 03 medical and health sciences, Medical microbiology, Drug Development, Virology, Epidemiology, Genetics, medicine, Animals, Humans, Chikungunya, Molecular Biology, 030304 developmental biology, Review Paper, Vaccines, 0303 health sciences, 030306 microbiology, Public health, CHIKV epidemiology, virus diseases, Outbreak, Viral Vaccines, General Medicine, medicine.disease, Drug development, Chikungunya Fever, Antiviral design, Monoclonal antibodies, Pre-Exposure Prophylaxis, Chikungunya virus
Abstract: Chikungunya virus (CHIKV) is a (re)emerging arbovirus and the causative agent of chikungunya fever. In recent years, CHIKV was responsible for a series of outbreaks, some of which had serious economic and public health impacts in the affected regions. So far, no CHIKV-specific antiviral therapy or vaccine has been approved. This review gives a brief summary on CHIKV epidemiology, spread, infection and diagnosis. It furthermore deals with the strategies against emerging diseases, drug development and the possibilities of testing antivirals against CHIKV in vitro and in vivo. With our review, we hope to provide the latest information on CHIKV, disease manifestation, as well as on the current state of CHIKV vaccine development and post-exposure therapy.
Published: 2021

26. Performance of equations to predict cardiovascular risk in an Argentine population

Author: Emanuel J. Saad, Malena Finello, Aldo H. Tabares, Ana F. Becerra, Esteban Foia, Marina L. Fernández, Alejandro Contreras, and Ricardo A. Albertini
Subjects: myocardial infarction, disease prevention, risk factors, Medicine, Infectious and parasitic diseases, RC109-216, Immunologic diseases. Allergy, RC581-607, stroke, cardiovascular diseases, acute coronary syndrome
Abstract: The performance of available risk scores to predict cardiovascular risk (CVR) in the Argentinian population is unknown. Our aim was to compare the CVR predicted by several equations with the occurrence of cardiovascular events (CVE) in patients without known cardiovascular disease in an Argentinian hospital. Adults between 40 and 70 years were randomly selected, excluding those with prior history of major CVE, active cancer, lipid lowering treatment and absence of follow-up data. Framingham 2008, SCORE (low and high-risk populations), ATP III, World Health Organization- American B region (WHO-B) and Pooled Cohort equations (PC) risk scores were used to calculate 10-y CVR at time of enrollment. End of follow-up was 10 years ± 6 months, occurrence of fatal myocardial infarction or death from any cause. We used ROC curves to assess discrimination (AUC > 0.75 good discrimination), and Hosmer Lemeshow chi-square to evaluate calibration (Chi > 20 or p value < 0.05 poor calibration). We included 606 patients in our study, 336 women, average age 56.7 ± 8.4 year. Of those, 10 (1.7%) non-cardiovascular deaths, and 5 (0.8%) cardiovascular deaths were observed. 58 (9.8%) a non-fatal CVE were recorded. There was acceptable discrimination for Framingham, ATP-III, and both PC equations. The global calibration was only good with the ATP-III and PC equations. The observed frequency of CVE was low, and the CVR was overestimated by all equations. However, applying ATP-III or PC equations to assess CVR could be considered in our population.
Published: 2021

27. Betamethasone versus dexamethasone for inpatient preschool wheezing—A case‐control study

Author: Regina Leshem, David Shoseyov, Joel Reiter, Alex Gileles-Hillel, Eitan Kerem, Oded Breuer, Malena Cohen-Cymberknoh, and Sharon Guttman
Subjects: Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Placebo, Betamethasone, Dexamethasone, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Humans, Medicine, Respiratory Sounds, Retrospective Studies, Asthma, Inpatients, Cumulative dose, business.industry, Medical record, Case-control study, Retrospective cohort study, medicine.disease, 030228 respiratory system, Case-Control Studies, Child, Preschool, Pediatrics, Perinatology and Child Health, business, medicine.drug
Abstract: BACKGROUND AND OBJECTIVES Wheezing is one of the most common reasons for the presentation of children to primary care or the emergency ward, before 7 years of age. Current guidelines recommend a short course of oral corticosteroids (OCS) for those children with a wheezing attack severe enough to require hospitalization. However, the optimal choice of therapy is controversial. We aimed to compare the efficacy of betamethasone to that of dexamethasone in achieving clinical response in preschool children requiring hospitalization for an acute wheezing attack. METHODS This was a retrospective study. Medical records of healthy children without significant comorbidities between 1 and 7 years of age (n = 234) admitted with a moderate-severity acute wheezing attack to two pediatric wards between 2014 and 2018 were included. All children were treated with either betamethasone or dexamethasone exclusively during the hospitalization. The primary outcome of interest was the length of hospital stay (LOS). RESULTS The demographic parameters and the clinical severity of wheezing episodes were similar in the two study groups, as was the LOS. However, the dexamethasone cumulative dose used during hospitalization was significantly larger than the betamethasone cumulative dose (3.76 (1.88-5.64) vs. 1.86 (1.24-3.1) mg/kg of prednisone-equivalent dose, p
Published: 2021

28. Using Prevent Teach Reinforce for Young Children to Manage Challenging Behaviors in Public Specialized Early Intervention Services for Autism

Author: Catherine Mello, Diane Morin, Mélina Rivard, Amélie Terroux, Jacques Forget, Zakaria Mestari, Christine Lefebvre, and Malena Argumedes
Subjects: Parents, medicine.medical_specialty, Autism Spectrum Disorder, Context (language use), law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Intervention (counseling), Early Intervention, Educational, Developmental and Educational Psychology, medicine, Humans, 0501 psychology and cognitive sciences, Autistic Disorder, Medical education, Parenting, Public health, 05 social sciences, Perspective (graphical), medicine.disease, Positive behavior support, Child, Preschool, Scale (social sciences), Autism, Psychology, 030217 neurology & neurosurgery, 050104 developmental & child psychology
Abstract: This proof-of-concept study assessed the feasibility of implementing Prevent-Teach-Reinforce-for-Young-Children (PTR-YC) program to address challenging behaviors in children with autism within the context of public, specialized early intensive behavioral intervention (EIBI) services offered in community settings. Following a 2-day training and with brief weekly supervision meetings, children's EIBI educators acted as facilitators in 35 families' home environments. Small and moderate effect sizes were observed for children's behavioral outcomes and parenting stress. Recruitment and retention rates, implementation fidelity, as well as treatment acceptability from the perspective of participating parents and the organization attested to the feasibility and relevance of implementing and evaluating this program on a larger scale as part of a multi-center randomized controlled trial.
Published: 2021

29. Nursing assistance in COVID-19 cardiovascular complications: Integrative Literature Review

Author: Catharina das Graças de Almeida Martins, Michele de Pinho Barreiros, Fernanda Araújo Trindade, Camila Cristina Girard Santos, Matheus Willame dos Passos, Anderson Lineu Siqueira dos Santos, George Pinheiro Carvalho, Chrisla Brena Malheiro Lima, Tatyellen Natasha da Costa Oliveira, Leidiane de Jesus da Costa Santos, Laryssa Cristiane Palheta Vulcão, Jéssica Maria Lins da Silva, Rodrigo Batista Balieiro, Alinne Larissa de Almeida Matos, Samantha Stephany Prado Brazão, Nicole Siqueira da Silva, Antônia Roberta Mitre Sampaio, Taynnara de Oliveira do Espírito Santo Cunha, MônicaCustódia do Couto Abreu Pamplona, Max José de Aviz Miranda, Paulo Victor Caldas Soares, Leticia Almeida de Assunção, Laina Carolina de Souza Araújo, Malena da Silva Almeida, Amanda Gomes Diniz Pimenta, Flávia Savana Ribeiro de Sales, Luceme Martins Silva, Rebecca Gabriela Queiroz Bernardo, Jéssica Luciana dos Santos Pereira, Hellen de Paula Silva da Rocha, Paula Carolina Lima de Aviz, Matheus Ataide Carvalho, Mônica Loureiro Maués Santos, Luana Estumano Longhi Bastos, Luciana Ramos, Maiza Silva de Sousa, Lorena Vasconcelos Almeida Soares, Caroline Martins da Silva Moia, Sandra Letícia Silva dos Santos, Ana Caroline Guedes Souza Martins, Alex de Oliveira Vasconcelos, Alda Lima Lemos, Angélica Menezes Bessa Oliveira, Suzana Elyse de Araujo Mac-Culloch, Ivonete Vieira Pereira Peixoto, Adriane Cardoso Silva de Sousa, Thais Garcia Raymond Franco, Ana Clara de Melo Ferreira, Michele Monteiro Sousa, Adryanne Alyce Carvalho Prata, Lauro Vicente Marron da Silva Filho, Gabriele Santos de Souza, Weslley do Vale Maia, Lorena Victória de Souza Ferreira, Camila dos Santos Moraes, Karolyne Joana Malcher Freire, Rayssa de Carvalho Baptista, Adrianne de Cassia Monteiro da Rocha, and Mayra Carolina de Carvalho
Subjects: Coronavirus disease 2019 (COVID-19), Nursing, business.industry, Integrative literature review, Medicine, business
Published: 2021

30. Measurements of the inclusive and differential production cross sections of a top-quark-antiquark pair in association with a Z boson at √s = 13 TeV with the ATLAS detector

Author: Aad, Georges, Abbott, Braden Keim, Abbott, Dale, Abed Abud, Adam, Abeling, Kira, Abhayasinghe, Deshan Kavishka, Abidi, Haider, Abouzeid, Hass, Abouzeid, Ossama, Abraham, Nicola Louise, Abramowicz, Halina, Abreu, Henso, Abulaiti, Yiming, Acharya, Bobby Samir, Achkar, Baida, Adam, Lennart, Adam Bourdarios, Claire, Adamczyk, Leszek, Adamek, Lukas, Adelman, Jahred, Adiguzel, Aytul, Adorni Braccesi Chiassi, Sofia, Adye, Tim, Adye, Timothy John, Affolder, Tony, Affolder, Anthony, Afik, Yoav, Agapopoulou, Christina, Agaras, Merve Nazlim, Aggarwal, Anamika, Agheorghiesei, Catalin, Aguilar Saavedra, Juan Antonio, Ahmad, Ammara, Ahmadov, Faig, Ahmed, Waleed Syed, Ai, Xiaocong, Aielli, Giulio, Akatsuka, Shunichi, Akbiyik, Melike, Akesson, Torsten, Akilli, Ece, Akimov, Andrei, Al Khoury, Konie, Alberghi, Gian Luigi, Albert, Justin, Verzini, M.J. Alconada, Alderweireldt, Sara, Aleksa, Martin, Aleksandrov, I.N., Alexa, Calin, Alexopoulos, Theodoros, Alfonsi, Alice, Alfonsi, Fabrizio, Alhroob, Muhammad, Ali, Babar, Ali, Shahzad, Aliev, Malik, Alimonti, Gianluca, Allaire, Corentin, Allbrooke, Benedict, Allen, Benjamin William, Allport, Philip Patrick, Aloisio, Alberto, Alonso, Francisco, Alpigiani, Cristiano, Alunno Camelia, Elio, Alvarez Estevez, Manuel, Alviggi, Mariagrazia, Do Amaral Coutinho, Yara, Ambler, Alessandro, Ambroz, Luca, Amelung, Christoph, Amidei, Dante, Amor dos Santos, Susana Patricia, Amoroso, Simone, Amrouche, Cherifa Sabrina, An, Fenfen, Anastopoulos, Christos, Andari, Nansi, Andeen, Timothy Robert, Anders, John Kenneth, Andrean, Stefio Yosse, Andreazza, Attilio, Andrei, Victor, Anelli, Christopher Ryan, Angelidakis, Stylianos, Angerami, Aaron, Anisenkov, Alexey, Annovi, Alberto, Antel, Claire, Anthony, Matthew Thomas, Antipov, Egor, Antonelli, Mario, Antrim, Daniel Joseph, Anulli, Fabio, Aoki, Masato, Aparisi Pozo, Javier Alberto, Aparo, Marco, Aperio Bella, Ludovica, Aranzabal Barrio, Nordin, Araujo Ferraz, Victor, Pereira, R.Araujo, Arcangeletti, Chiara, Arce, Ayana Tamu, Arguin, Jean-Francois, Argyropoulos, Spyros, Argyropoulos, Spyridon, Arling, Jan-Hendrik, Armbruster, Aaron James, Armstrong, Alexander, Arnaez, Olivier, Arnold, Hannah, Arrubarrena Tame, Zulit Paola, Artoni, Giacomo, Asada, Haruka, Asai, Kanae, Asai, Shoji, Asawatavonvanich, Thanawat, Asbah, Nedaa Alexandra, Asimakopoulou, Eleni Myrto, Asquith, Lily, Assahsah, Jihad, Assamagan, Ketevi Adikle, Astalos, Robert, Atkin, Ryan Justin, Atkinson, Markus Julian, Atlay, Naim Bora, Atmani, Hicham, Atmasiddha, Prachi, Augsten, Kamil, Austrup, Volker Andreas, Avolio, Giuseppe, Ayoub, Mohamad Kassem, Azuelos, Georges, Babal, Dominik, Bachacou, Henri, Bachas, Dinos, Bachas, Konstantinos, Backman, Karl Filip, Bagnaia, Paolo, Bahrasemani, H., Bahrasemani, Sina, Bailey, Adam, Bailey, Virginia, Baines, John, Bakalis, Christos, Baker, Keith, Bakker, Pepijn Johannes, Bakos, Evelin, Bakshi Gupta, Debottam, Balaji, Shyam, Balasubramanian, Rahul, Baldin, Evgenii, Balek, Petr, Balli, Fabrice, Balunas, William Keaton, Balz, Johannes, Banas, Elzbieta, Bandieramonte, Marilena, Bandyopadhyay, Anjishnu, Banerjee, Sw., Banerjee, Swagato, Barak, Liron, Barbe, William Mickael, Barberio, Elisabetta, Barberis, Dario, Barbero, Marlon Benoit, Barbour, Gregory, Barillari, Teresa, Barisits, Martin, Barkeloo, Jason Tyler Colt, Barklow, Tim, Barklow, Timothy Laurence, Barnea, Rotem, Barnett, Bruce M, Barnett, Michael, Barnovska-Blenessy, Z., Baroncelli, Toni, Baroncelli, Antonio, Barone, Gaetano, Barr, Alan, Barranco Navarro, Laura, Barreiro Alonso, Fernando, Barreiro Guimaraes da Costa, Joao, Barron, Uriel, Barsov, Sergey, Bartels, Falk, Bartoldus, Rainer, Bartolini, Giovanni, Barton, Adam Edward, Bartos, Pavol, Basalaev, Artem, Basan, Alexander, Bassalat, Ahmed, Basso, Matthew Joseph, Bates, Richard, Batlamous, Souad, Batley, Richard, Batool, Binish, Battaglia, Marco, Bauce, Matteo, Bauer, Florian, Bauer, Patrick, Bawa, Harinder Singh, Bayirli, Arif, Beacham, James, Beau, Tristan, Beauchemin, Pierre-Hugues, Becherer, Fabian, Bechtle, Philip, Beck, Helge Christoph, Beck, Hans Peter, Beck, Hanspeter, Becker, Kathrin, Becot, Cyril Pascal, Beddall, Ayda, Beddall, Andrew, Bednyakov, Vadim, Bedognetti, Matteo, Bee, Chris, Bee, Christopher Peter, Beermann, Thomas, Begalli, Marcia, Begel, Michael, Behera, Arabinda, Behr, Janna Katharina, Beisiegel, Florian, Belfkir, Mohamed, Bell, Andrew Stuart, Bella, Gideon, Bellagamba, Lorenzo, Bellerive, Alain, Bellos, Panagiotis, Beloborodov, Konstantin, Belotskiy, Konstantin, Belyaev, Nikita, Benchekroun, Driss, Benekos, Nectarios, Benhammou, Yan, Benjamin, Doug, Benjamin, Douglas Paul, Benoit, Mathieu, Bensinger, Jim, Bensinger, James, Bentvelsen, Stan, Bentvelsen, Stanislaus, Beresford, Lydia Audrey, Beretta, Matteo Mario, Berge, David, Bergeaas Kuutmann, Elin, Berger, Nicolas, Bergmann, Benedikt Ludwig, Bergsten, Laura Jean, Beringer, Juerg, Berlendis, Simon, Bernardi, Gregorio, Bernius, Catrin, Bernlochner, Florian Urs, Berry, Tracey, Berta, Peter, Berthold, Anne-Sophie, Bertram, Iain, Bessidskaia Bylund, Olga, Besson, Nathalie, Bethke, Siegfried, Betti, Alessandra, Bevan, Adrian, Beyer, Julien-Christopher, Bhatta, Somadutta, Bhattacharya, Deb Sankar, Bhattarai, Prajita, Bhopatkar, Vallary Shashikant, Bi, Runyu, Bianchi, Riccardo Maria, Biebel, Otmar, Biedermann, Dustin, Bielski, Rafal, Bierwagen, Katharina, Biesuz, Nicolo Vladi, Biglietti, Michela, Billoud, T.R. V., Bindi, Marcello, Bingul, Ahmet, Bini, Cesare, Biondi, Silvia, Birch-Sykes, Callum Jacob, Birman, Mattias, Bisanz, Tobias, Biswal, Jyoti Prakash, Biswas, Diptaparna, Bitadze, Alexander, Bittrich, Carsten, Bjoerke, Kristian, Blazek, Tomas, Bloch, Ingo, Blocker, Craig, Blue, Andrew James, Blumenschein, Ulla, Blumenschein, Heidrun, Bobbink, Gerjan, Bobbink, Gerard, Bobrovnikov, Viktor, Bocchetta, Simona, Bogavac, Danijela, Bogdanchikov, Alexander, Bohm, Christian, Boisvert, Veronique, Bokan, Petar, Bold, Tomasz, Bolz, Arthur Eugen, Bomben, Marco, Bona, Marcella, Bonilla, Johan Sebastian, Boonekamp, Maarten, Booth, Callum Dale, Borbely, Albert Gyorgy, Borecka-Bielska, Hanna Maria, Borgna, Lucas Santiago, Borisov, Anatoli, Borissov, Guennadi, Bortoletto, Daniela, Boscherini, Davide, Fernandez-Bosman, Martine, Sola, J.D. Bossio, Bouaouda, Khalil, Boudreau, Joseph, Bouhova-Thacker, E.V., Bouhova-Thacker, Evelina Vassileva, Boumediene, Djamel Eddine, Boveia, Antonio, Boyd, Jamie, Boyd, James, Boye, Diallo, Boyko, Igor, Bozson, Adam, Bracinik, Juraj, Brahimi, Nihal, Brandt, Gerhard Immanuel, Brandt, Oleg, Braren, Frued Erik, Brau, Benjamin Paul, Brau, J.E., Brau, James Edward, Breaden Madden, Will, Breaden Madden, William Dmitri, Brendlinger, Kurt, Schimmel Brener, Roy, Brenner, Lydia, Brenner, Richard, Bressler, Shikma, Brickwedde, Bernard, Briglin, Daniel Lawrence, Britton, David, Britzger, Daniel Andreas, Brock, Ian, Brock, Raymond, Brooijmans, Gustaaf, Brooks, William King, Brost, Elizabeth, Bruckman de Renstrom, Pawel, Bruers, Ben, Bruncko, Dusan, Bruni, Alessia, Bruni, Graziano, Bruschi, Marco, Bruscino, Nello, Bryngemark, Lene Kristian, Buanes, Trygve, Buat, Quentin, Buchholz, Peter, Buckley, Andy, Budagov, Ioulian, Buckley, Andrew Gordon, Budagov, Yulian, Bugge, Magnar Kopangen, Bulekov, Oleg, Bullard, Brendon, Burch, Tyler James, Burdin, Sergey, Burgard, Carsten Daniel, Burger, Angela Maria, Burghgrave, Blake Oliver, Burr, Jon, Burr, Jonathan, Burton, Charles, Burzynski, Jackson Carl, Buescher, Volker, Buschmann, Eric, Bussey, Peter John, Butler, John Mark, Buttar, Craig, Butterworth, Jonathan, Butti, Pierfrancesco, Buttinger, Will, Buttinger, William, Buxo Vazquez, Carlos Josue, Buzatu, Adrian, Buzykaev, Alexey, Buzykaev, Aleksey, Cabras, Grazia, Cabrera Urban, Susana, Caforio, Davide, Cai, Huacheng, Cairo, Valentina, Cakir, Orhan, Calace, Noemi, Calafiura, Paolo, Calderini, Giovanni, Calfayan, Philippe, Callea, Giuseppe, Caloba, Luiz, Caltabiano, Alessandro, Calvente Lopez, Sergio, Calvet, David, Calvet, Samuel, Calvet, Thomas Philippe, Calvetti, Milene, Camacho Toro, Reina Coromoto, Camarda, Stefano, Camarero Munoz, Daniel, Camarri, Paolo, Camerlingo, Maria Teresa, Cameron, David, Camincher, Clement, Campana, Simone, Campanelli, Mario, Camplani, Alessandra, Canale, Vincenzo, Canesse, Auriane, Bret Cano, Marc, Cantero Garcia, Josu, Cao, Tingting, Cao, Yumeng, Garrido, M.D. M.Capeans, Capua, Marcella, Cardarelli, Roberto, Cardillo, Fabio, Carducci, Giovandomenico, Carli, Ina, Carli, Tancredi, Carlino, Giampaolo, Carlson, B.T., Carlson, Benjamin Taylor, Carlson, Evan Michael, Carminati, Leonardo, Carney, Rebecca, Caron, Sascha, Carquin Lopez, Edson, Carra, Sonia, Carratta, Giuseppe, Carter, J.W. S., Carter, Thomas Michael, Casado Lechuga, Pilar, Casha, Albert Francis, Castiglia, Emma Grace, Castillo, Florencia Luciana, Castillo Garcia, Lucia, Castillo Gimenez, Victoria, Castro, Nuno, Catinaccio, Andrea, Catmore, James, Cattai, Ariella, Cavaliere, Viviana, Cavasinni, Vincenzo, Celebi, Emre, Celli, Federico, Cerny, Karel, Santiago Cerqueira, Augusto, Cerri, Alex, Cerri, Alessandro, Cerrito, Lucio, Cerutti, Fabio, Cervelli, Alberto, Cetin, Serkant, Chadi, Zakaria, Chakraborty, Dhiman, Chan, Jay, Chan, Chen-Hsun, Chan, Terry Ws, Chan, Wing Sheung, Chan, Wai Yuen, Chapman, John Derek, Chargeishvili, Bakar, Charlton, Dave, Charlton, David, Charman, Thomas Paul, Chatterjee, Meghranjana, Chau, Chav Chhiv, Che, Siinn, Chekanov, Sergei, Chekulaev, Sergey, Chelkov, G.A., Chen, Boping, Chen, Cheng, Chen, Chunhui, Chen, Huirun, Chen, Hucheng, Chen, Jing, Chen, Jue, Chen, Jiayi, Chen, Shion, Chen, Shenjian, Chen, Xin, Chen, Ye, Chen, Yu-Heng, Cheng, Hok Chuen, Cheng, Huajie, Cheplakov, Alexander, Cheremushkina, Evgeniya, Cherkaoui El Moursli, Rajaa, Cheu, Elliott, Cheung, Kingman, Chevalerias, Thibault, Chevalier, Laurent, Chiarella, Vitaliano, Chiarelli, Giorgio, Chiodini, Gabriele, Chisholm, Andrew Stephen, Chitan, Adrian, Chiu, I-Huan, Chiu, Justin, Chiu, Y.H., Chizhov, Mihail, Choi, Kyungeon, Chomont, Arthur, Chou, Yuan-Tang, Chow, Edwin, Chow, Yun Sang, Christopher, Lawrence Davou, Chu, Ming Chung, Chu, Xiaotong, Chudoba, Jiri, Chwastowski, Janusz, Chytka, Ladislav, Cieri, Davide, Ciesla, Krzysztof, Cindro, Vladimir, Cioara, Irina Antonela, Ciocio, Alessandra, Cirotto, Francesco, Citron, Z.H., Citterio, Mauro, Ciubotaru, Dan Andrei, Ciungu, Bianca Monica, Clark, Allan, Clark, Philip, Clawson, Savannah, Clement, Christophe, Coadou, Yann, Cobal, Marina, Coccaro, Andrea, Cochran, James Herbert, Coelho Lopes de Sa, Rafael, Cohen, Hadar, Coimbra, A.E. C., Cole, Brian, Colijn, Auke-Pieter, Collot, Johann, Conde Muino, Patricia, Connell, Simon, Connelly, Ian Allan, Constantinescu, Serban, Conventi, Francesco, Cooper-Sarkar, A.M., Cormier, Felix, Cormier, Kyle James Read, Corpe, Louie Dartmoor, Corradi, Massimo, Corrigan, Eric Edward, Corriveau, Francois, Costa Mezquita, Maria Jose, Costanza, Francesco, Costanzo, Davide, Cowan, Glen, Cowley, James William, Crane, Jonathan, Cranmer, Kyle Stuart, Creager, Rachael Ann, Crepe-Renaudin, Sabine, Crescioli, Francesco, Cristinziani, Markus, Croft, Vincent Alexander, Crosetti, Giovanni, Dandoy, Jeffrey Rogers, Crosetti, Nanni, Cueto Gomez, Ana Rosario, Cuhadar Donszelmann, Tulay, Cui, Han, Cukierman, Aviv Ruben, Cunningham, William Reilly, Cunningham, Liam, Czekierda, Sabina Anna, Czodrowski, Patrick Karl, Czurylo, Marta Maja, da Cunha Sargedas de Sousa, M.J., da Fonseca Pinto, Joao Victor, da Via, Cinzia, Dabrowski, Wladyslaw, Dachs, Florian, Dado, Tomas, Dahbi, Salah-Eddine, Dai, Tiesheng, Dallapiccola, Carlo, Dam, Mogens, d'Amen, Gabriele, d'Amico, Valerio, Damp, Johannes Frederic, Dandoy, Jeff, Daneri, Maria Florencia, Danninger, Matthias, Dao, Valerio, Darbo, Giovanni, Darbo, Nanni, Dartsi, Olympia, Dattagupta, Aparajita, Daubney, Thomas, d'Auria, Saverio, David, Claire, Davidek, Tomas, Davis, Douglas Raymond, Dawson, Ian, De, Kaushik, de Asmundis, Riccardo, de Beurs, Marcus, de Castro, Stefano, de Groot, Nicolo, de Jong, Paul, de la Torre Perez, Hector, de Maria, Antonio, de Pedis, Daniele, de Salvo, Alessandro, de Sanctis, Umberto, de Santis, Maurizio, de Santo, Antonella, de Vivie de Regie, Jean-Baptiste, Dedovich, Dmitri, Deiana, Allison Mccarn, del Peso, Jose, Delabat Diaz, Yasiel, Delgove, David, Deliot, Frederic, Delitzsch, Chris Malena, Della Pietra, Massimo, Della Volpe, Domenico, Dell'Acqua, Andrea, Dell'Asta, Lidia, Delmastro, Marco, Delporte, Charles Eliaz, Delsart, Pierre Antoine, Demers Konezny, Sarah Marie, Demichev, Mikhail, Demontigny, Gabriel, Denisov, Serguei, d'Eramo, Louis, Derendarz, Dominik Karol, Derkaoui, Jamal, Derue, Frederic, Dervan, Paul, Desch, Klaus, Dette, Karola, Deutsch, Christopher, Devesa, Maria Roberta, Deviveiros, Pier-Olivier, Di Bello, Francesco Armando, Di Ciaccio, Anna, Di Ciaccio, Lucia, Di Clemente, William Kennedy, Di Clemente, Will, Di Donato, Camilla, Di Girolamo, Alessandro, Di Gregorio, Giulia, Di Luca, Andrea, Di Micco, Biagio, Di Nardo, Roberto, Di Petrillo, Karri Folan, Di Sipio, Riccardo, Diaconu, Cristinel, de Almeida Dias, Flavia, Vale, T.Dias Do, Diaz Gutierrez, Marco Aurelio, Diaz Capriles, Federico Guillermo, Dickinson, Jennet Elizabeth, Didenko, Mariia, Diehl, Edward, Dietrich, Janet, Diez Cornell, Sergio, Diez Pardos, Carmen, Dimitrievska, Aleksandra, Ding, Wei, Dingfelder, Jochen Christian, Dittmeier, Sebastian, Dittus, Fridolin, Dittus, Fido, Djama, Fares, Djobava, Tamar, Djuvsland, Julia Isabell, Barros Do Vale, Aline, Dobre, Monica, Dodsworth, David Michael, Doglioni, Caterina, Dolejsi, Jiri, Dolezal, Zdenek, Donadelli, Marisilvia, Dong, Binbin, Donini, Julien Noce, d'Onofrio, Adelina, d'Onofrio, Monica, Dopke, Jens, Doria, Alessandra, Dova, Maria Teresa, Doyle, Anthony Terence, Doyle, Tony, Drechsler, Eric, Dreyer, Etienne, Dreyer, Timo, Drobac, Alec Swenson, Du, Dongshuo, Du Pree, Tristan Arnoldus, Duan, Yanyun, Dubinin, Filipp, Dubovsky, Michal, Dubreuil, Arnaud, Duchovni, Ehud, Duckeck, Guenter, Ducu, Otilia Anamaria, Duda, Dominik, Dudarev, Alexey, Dudder, Andreas Christian, Duffield, Emily Marie, d'Uffizi, Matteo, Duflot, Laurent, Duehrssen-Debling, Michael, Dulsen, Carsten, Dumancic, Mirta, Dumitriu, Ana Elena, Dunford, Monica, Dungs, Sascha, Duperrin, Arnaud, Yildiz, H.Duran, Ellis, Nicolas, Yildiz, Duran, Dueren, Michael Johannes, Durglishvili, Archil, Duschinger, Dirk Uwe, Dutta, Baishali, Duvnjak, Damir, Dyckes, G.I., Dyndal, Mateusz, Dysch, Samuel Dezso, Dziedzic, Bartosz Sebastian, Eggleston, Michael Glenn, Eifert, Till, Eigen, Gerald, Einsweiler, Kevin Frank, Ekelof, Tord Johan Carl, El Jarrari, Hassnae, Ellajosyula, Venugopal, Ellert, Mattias, Ellinghaus, Frank, Elliot, Alison, Emerman, Alexander Zack, Evans, Harold, Ellis, Nick, Elmsheuser, Johannes, Elsing, Markus, Emeliyanov, Dmitry, Emerman, Alex, Enari, Yuji, Epland, Matthew, Erdmann, Johannes, Ereditato, Antonio, Erland, Paula Agnieszka, Errenst, Martin, Escalier, Marc, Escobar Ibanez, Carlos, Estrada Pastor, Oscar, Etzion, Erez, Gaspar de Andrade Evans, Guiomar, Evans, Hal, Evans, Meirin Oan, Ezhilov, Aleksei, Fabbri, Federica, Fabbri, Laura, Fabiani, Veronica, Facini, Gabriel, Fakhrutdinov, Rinat, Falciano, Speranza, Falke, Peter Johannes, Falke, Saskia, Faltova, Jana, Fang, Yi, Fang, Yaquan, Fanourakis, Georgios, Fanti, Marcello, Faraj, Mohammed, Farbin, Amir, Farilla, Addolorata, Fedorko, Wojciech Tadeusz, Fell, Alexandra, Farilla, Ada, Farina, Edoardo Maria, Farooque, Trisha, Farrington, Sinead, Farthouat, Philippe, Fassi, Farida, Fassnacht, Patrick, Fassouliotis, Dimitris, Faucci Giannelli, Michele, Fawcett, William James, Fayard, Louis, Fedin, Oleg, Fedorko, Wojtek, Fehr, Armin, Feickert, Matthew Carl, Feligioni, Lorenzo, Fell, Alix, Feng, Cunfeng, Feng, Minyu, Fenton, Michael James, Fenyuk, Alexandre, Ferguson, Sarah Whitney, Ferrando, James Edward, Ferrari, Arnaud, Ferrari, Pamela, Ferrari, Roberto, Ferreira de Lima, Danilo Enoque, Ferrer Soria, Antonio, Ferrere, Didier, Ferretti, Claudio, Fiedler, Frank, Filipcic, Andrej, Filthaut, Frank, Finelli, Kevin Daniel, Castro Nunes Fiolhais, Miguel, Fiorini, Luca, Fischer, Florian, Fischer, Julian, Fisher, Wade Cameron, Fitschen, Tobias, Fleck, Ivor, Fleischmann, Philipp, Flick, Tobias, Flierl, Bernhard Matthias, Flores, Lucas Macrorie, Flores Castillo, Luis Roberto, Follega, Francesco Maria, Fomin, Nikolai, Foo, Joel Hengwei, Forcolin, Giulio Tiziano, Forland, Blake Christopher, Formica, Andrea, Forster, Fabian Alexander, Forti, Alessandra, Fortin, Etienne Marie, Foti, Maria Giovanna, Fournier, Daniel, Fox, Harald, Francavilla, Paolo, Francescato, Simone, Franchini, Matteo, Franchino, Silvia, Francis, David, Franco, Luca, Franconi, Laura, Franklin, Melissa, Frattari, Guglielmo, Fray, Antony, Freeman, Patrick Moriishi, Freund, Benjamin, Spolidoro Freund, Werner, Freundlich, Elena Murielle, Frizzell, Dylan Cooper, Froidevaux, Daniel, Frost, James, Fujimoto, Minori, Fukunaga, Chikara, Fullana Torregrosa, Esteban, Fusayasu, Takahiro, Fuster Verdu, Juan, Gabrielli, Alessandro, Gabrielli, Andrea, Gadatsch, Stefan, Gadow, Paul Philipp, Gagliardi, Guido, Gagnon, Louis-Guillaume, Gallardo, Gabriel, Gallas, Elizabeth, Gallop, Bruce Joseph, Gamboa Goni, Rodrigo, Gan, Kock Kiam, Ganguly, Sanmay, Gao, Jun, Gao, Yanyan, Gao, Yongsheng, Garay Walls, Francisca, Garcia, Carmen, Garcia Navarro, Jose Enrique, Garcia Pascual, Juan Antonio, Garcia, Juanan, Garcia Argos, Carlos, Garcia-Sciveres, Maurice, Gardner, Robert William, Garelli, Nicoletta, Gargiulo, Simona, Garner, Christopher Andrew, Garonne, Vincent, Gasiorowski, Sean Joseph, Do Nascimento Gaspar, Philipp, Gaudiello, Andrea, Gaudio, Gabriella, Gauzzi, Paolo, Gavrilenko, Igor, Gavriliuk, Aleksandr, Gay, Colin Warren, Gaycken, Goetz, Gazis, Evangelos, Geanta, Andrei Alexandru, Gee, Carolyn, Gee, C.N. P., Geisen, Jannik, Geisen, Marc, Gemme, Claudia, Genest, Marie-Helene, Geng, Cong, Gentile, Simonetta, George, Simon, Geralis, Theodoros, Gerlach, Lino Oscar, Gessinger-Befurt, Paul, Gessner, Gregor, Ghasemi Bostanabad, Meisam, Ghneimat, Mazuza, Ghosh, Aishik, Ghosh, Anindya, Giacobbe, Benedetto, Giagu, Stefano, Giangiacomi, Nico, Giannetti, Paola, Giannini, Antonio, Giannini, Giulia, Gibson, Stephen, Gignac, Matthew, Gil, Damian Tomasz, Gilbert, Benjamin Jacob, Gillberg, Dag, Gilles, Geoffrey, Gillwald, N.E. K., Gingrich, Douglas, Giordani, Mario, Gingrich, Doug, Giordani, Mapo, Giraud, Pierre-Francois, Giugliarelli, Gilberto, Giugni, Danilo, Giuli, Francesco, Gkaitatzis, Stamatios, Gkialas, Ioannis, Gkougkousis, Evangelos Leonidas, Gkougkousis, Vagelis, Gkountoumis, Panagiotis, Gladilin, Leonid, Glasman, Claudia, Glatzer, Julian, Glaysher, P.C. F., Glazov, Alexander, Gledhill, Galen Rhodes, Gnesi, Ivan, Goblirsch-Kolb, Maximilian Emanuel, Godin, Dominique, Goldfarb, Steven, Golling, Tobias, Golubkov, Dmitry, da Silva Gomes, Agostinho, Goncalves Gama, Rafael, Morais Silva Goncalo, Ricardo Jose, Gonella, Giulia, Gonella, Laura, Gongadze, Alexi, Gonnella, Francesco, Gonski, Julia Lynne, Gonzalez de la Hoz, Santiago, Gonzalez Fernandez, Sergio, Gonzalez Lopez, Ricardo, Gonzalez Renteria, Cesar, Gonzalez Suarez, Rebeca, Gonzalez Sevilla, Sergio, Gonzalvo Rodriguez, Galo Rafael, Goossens, Luc, Gorasia, Nandish Arjan, Gorbounov, Petr, Gordon, Howard, Gorini, Benedetto, Gorini, Edoardo, Gorisek, Andrej, Goshaw, Alfred Thomas, Goshaw, A.T., Gostkin, Mikhail, Gottardo, Carlo Alberto, Gouighri, Mohamed, Goussiou, Anna, Govender, Nicolin, Goy, Corinne, Grabowska-Bold, Iwona, Graham, Emily Charlotte, Gramling, Johanna, Gramstad, Eirik, Grancagnolo, Sergio, Grandi, Mario, Grachev, Vadim, Gravila, Paul, Gravili, Francesco Giuseppe, Gray, Chloe, Gray, Heather, Grefe, Christian, Gregersen, Kristian Damlund, Gregor, Ingrid, Grenier, Philippe, Grevtsov, Kirill, Grieco, Chiara, Grieser, Nathan Allen, Grillo, Alex, Grimm, Kathryn, Grinstein, Sebastian, Grivaz, Jean-Francois, Groh, Sabrina, Gross, Eilam, Grosse-Knetter, Joern, Grout, Zara Jane, Grud, Christopher Ryan, Grummer, Aidan, Grundy, James Cameron, Guan, Liang, Guan, Wen, Gubbels, Christopher, Hance, Michael, Gubbels, Chris, Guenther, Jaroslav, Guerguichon, Antinea, Rojas, J.G. R.Guerrero, Guescini, Francesco, Guest, Daniel Hay, Guest, Dan, Gugel, Ralf, Guida, Alessandro, Guillemin, Thibault, Guindon, Stefan, Guo, Jun, Guo, Wen, Guo, Yicheng, Guo, Ziyu, Gupta, Ruchi, Gurbuz, Saime, Gustavino, Giuliano, Guth, Manuel, Gutierrez, Phillip, Gutschow, Christian, Guyot, Claude, Gwenlan, Claire, Gwilliam, Carl, Haaland, Even Simonsen, Haas, Andrew, Haber, Carl, Hadavand, Haleh, Hadef, Asma, Haleem, Mahsana, Haley, Joseph, Hall, Jack Joseph, Halladjian, Garabed, Hallewell, Gregory, Hamano, Kenji, Hamdaoui, Hassane, Hamer, Matthias, Hamity, Guillermo Nicolas, Han, Kunlin, Han, Liangliang, Han, Liang, Han, Shuo, Han, Yi Fei, Hanagaki, Kazunori, Hawkes, Christopher, Hays, Christopher Paul, Hance, Mike, Handl, David Michael, Hank, Michael Donald, Hankache, Robert, Hansen, Eva Brottmann, Hansen, Jorgen Beck, Hansen, Dines, Hansen, Maike Christina, Hansen, Peter, Hanson, Emily Claire, Hara, Kazuhiko, Harenberg, Torsten, Harkusha, Siarhei, Harrison, Paul Fraser, Hartman, Nicole Michelle, Hartmann, Nikolai, Hasegawa, Yoji, Hasib, Ahmed, Hassani, Samira, Haug, Sigve, Hauser, Reiner, Havranek, Miroslav, Hawkes, Chris, Hawkings, Richard, Hayashida, Shota, Hayden, Daniel, Hayes, Christopher Robyn, Hayes, Robin, Hays, Chris, Hays, Jonathan, Hayward, Helen, Haywood, Stephen, He, Fudong, He, Yunjian, Heath, Matthew Peter, Hedberg, Vincent, Heggelund, Andreas Lokken, Hehir, Natasha, Heidegger, Constantin, Heidegger, Kim Katrin, Heidorn, William Dale, Heilman, Jesse Alan, Heim, Sarah, Heim, Timon, Heinemann, Beate, Heinlein, James Geddy, Heinrich, Jochen Jens, Heinrich, Lukas Alexander, Hejbal, Jiri, Helary, Louis, Held, Alexander, Hellesund, Simen, Helling, Cole Michael, Hellman, Sten, Helsens, Clement, Henderson, R.C. W., Henkelmann, Lars, Henriques Correia, Ana Maria, Herde, Hannah Elizabeth, Hernandez Jimenez, Yesenia, Herr, Holger Arnold, Herrmann, Maximilian Georg, Herrmann, Tim, Herten, Gregor, Hertenberger, Ralf, Hervas, Luis, Herwig, Christian, Hesketh, Gavin, Hessey, Nigel, Hibi, Hiroaki, Higashino, Satoshi, Higon-Rodriguez, Emilio, Hildebrand, Kevin, Hill, John, Hill, Kurt Keys, Hiller, Karlheinz, Hillier, Stephen, Hils, Maximilian, Hinchliffe, Ian, Hinterkeuser, Florian, Hirose, Minoru, Hirose, Shigeki, Hirschbuehl, Dominic, Hiti, Bojan, Hladik, Ondrej, Hobbs, John David, Hobincu, Radu, Tal Hod, Noam, Hodgkinson, Mark, Hoecker, Andreas, Hohn, David, Hohov, Dmytro, Holm, Tanja, Holmes, Tova, Holzbock, Michael, Hommels, L.B. A.H., Hong, Tae Min, Honig, Jan Cedric, Honle, Andreas, Hooberman, Benjamin Henry, Hopkins, Walter, Horii, Yasuyuki, Horn, Philipp, Horyn, Lesya Anna, Hou, Suen, Hoummada, Abdeslam, Howarth, James William, Hoya, Joaquin, Hrabovsky, Miroslav, Hrivnac, Julius, Hrynevich, Aliaksei, Hrynova, Tetiana, Hsu, Pai-Hsien, Hsu, Shih-Chieh, Hu, Qipeng, Hu, Shuyang, Hu, Yifan, Huang, Danping, Huang, Xiaozhong, Huang, Yicong, Huang, Yanping, Hubacek, Zdenek, Hubaut, Fabrice, Hubner, Michael, Huegging, Fabian, Huffman, Todd Brian, Huhtinen, Mika, Hulsken, Raphael, Hunter, Robert Francis, Huseynov, Nazim, Huston, Joey, Huth, John, Hyneman, Rachel Jordan, Hyrych, Sofiia, Iacobucci, Giuseppe, Iakovidis, Georgios, Iakovidis, George, Ibragimov, Iskander, Iconomidou-Fayard, Lydia, Iengo, Paolo, Ignazzi, Rosanna, Iguchi, Ryunosuke, Iizawa, Tomoya, Ikegami, Yoichi, Ikeno, Masahiro, Ilic, Nikolina, Iltzsche, Franziska, Imam, Hajar, Introzzi, Gianluca, Iodice, Mauro, Iordanidou, Kalliopi, Ippolito, Valerio, Isacson, Max Fredrik, Ishino, Masaya, Islam, Wasikul, Issever, Cigdem, Istin, Serhat, Ponce, J.M. Iturbe, Iuppa, Roberto, Ivina, Anna, Izen, Joseph Michael, Izzo, Vincenzo, Jacka, Petr, Jackson, Paul, Jacobs, Ruth Magdalena, Jaeger, Benjamin Paul, Jain, Vivek, Jakel, Gunnar, Jakobi, Katharina Bianca, Jakobs, Karl, Jakoubek, Tomas, Jamieson, Jonathan, Janas, Krzysztof, Jansky, Roland, Janus, Michel, Janus, Piotr Andrzej, Jarlskog, Goran, Jaspan, Adam Elliott, Javadov, Namig, Javurek, Tomas, Javurkova, Martina, Jeanneau, Fabien, Jeanty, Laura, Jejelava, Juansher, Jenni, Peter, Jeong, Namgyun, Jezequel, Stephane, Jia, Jiangyong, Jia, Zihang, Jiang, Hai, Jiang, Yi, Jiang, Zihao, Jiggins, Stephen, Jimenez Morales, Fabricio Andres, Jimenez Pena, Javier, Jin, Shan, Jinaru, Adam, Jinnouchi, Osamu, Jivan, Harshna, Johansson, Per Daniel Conny, Johns, Kenneth, Johnson, Christian, Jones, Eleanor, Jones, R.W. L., Jones, Samuel David, Jones, Timothy John, Jones, T.J., Jovicevic, Jelena, Ju, Xiangyang, Junggeburth, Johannes Josef, Juste Rozas, Aurelio, Kaczmarska, Anna, Kado, Marumi, Kagan, Harris, Kagan, Michael Aaron, Kahn, Alan Mathew, Kahra, Christian, Kaji, Toshiaki, Kajomovitz Must, Enrique, Kalderon, Charles William, Kartvelishvili, Vakhtang, Kastanas, Konstantinos, Kalderon, Will, Kaluza, Adam, Kamenshchikov, Andrey, Kaneda, Michiru, Kang, Nathan Jihoon, Kang, Shuaiyan, Kano, Yuya, Kanzaki, Junichi, Kaplan, Laser Seymour, Kar, Deepak, Karava, Kla, Kareem, Mohammad, Karkanias, Ioannis, Karpov, Sergey, Karpova, Zoya, Kartvelishvili, Vato, Karyukhin, Andrei, Kasimi, Eirini, Kastanas, Alex, Kato, Chikuma, Katzy, Judith, Kawade, Kentaro, Kawagoe, Kiyotomo, Kawaguchi, Tomomi, Kawamoto, Tatsuo, Kawamura, Gen, Kay, Ellis, Kaya, Fikriye Idil, Kaya, Colette, Kazakos, Stergios, Kazanin, Vassili, Keaveney, James Michael, Keeler, Richard, Keller, John Stakely, Kellermann, Edgar, Kelsey, Daniel Christopher, Kempster, Jacob Julian, Kendrick, James Andrew, Kennedy, Kiley Elizabeth, Kepka, Oldrich, Kersten, Susanne, Kersevan, Borut Paul, Haghighat, S.Ketabchi, Khalil-Zada, Farhad, Khandoga, Mykola, Khanov, Alexander, Kharlamov, Alexey, Kharlamova, Tatyana, Khoda, Elham E, Khoo, Teng Jian, Khoriauli, Gia, Khramov, Evgeny, Khubua, J., Khubua, Djemal, Kido, Shogo, Kiehn, Moritz, Kim, Eunchong, Kim, Young-Kee, Kimura, Naoki, Kirchhoff, Andreas, Kirchmeier, David, Kirk, Julie, Kiryunin, Andrei, Kishimoto, Tomoe, Kisliuk, Dylan Perry, Kitali, Vincent, Kitsaki, Chara, Kivernyk, Oleh, Klapdor-Kleingrothaus, Thorwald, Klassen, Martin, Klein, Christoph Thomas, Klein, Matthew Henry, Klein, Max, Klein, Uta, Kleinknecht, Konrad, Klimek, Pawel Jan, Klimentov, Alexei, Klimpel, Fabian, Klingl, Tobias, Klioutchnikova, Tatiana, Klitzner, Felix Fidelio, Kluit, Peter, Kluth, Stefan, Kneringer, Emmerich, Knoops, E.B. F.G., Knue, Andrea Helen, Kobayashi, Dai, Kobel, Michael, Kocian, Martin, Kodama, Takafumi, Kodys, Peter, Koeck, D.M., Kock, Daniela, Konig, Philipp, Koffas, Thomas, Koehler, Nicolas, Kolb, Mathis, Koletsou, Iro, Komarek, Tomas, Kondo, Takahiko, Kordas, Konstantinos, Kondo, Taka, Koeneke, Karsten, Kong, A.X. Y., Konig, Adriaan Clemens, Kono, Takanori, Konstantinides, Vasilis, Konstantinidis, Nikolaos, Konya, Balazs, Kopeliansky, Revital, Koperny, Stefan Zenon, Korcyl, Krzysztof Marian, Kordas, Kostas, Koren, Guy, Korn, Andreas, Korolkov, Ilya, Korolkova, Elena, Korotkova, Natalia, Kortner, Oliver, Kortner, Sandra, Kostyukhin, Vadim, Kotsokechagia, Anastasia, Kotwal, Ashutosh, Koulouris, Aimilianos, Kourkoumeli-Charalampidi, Athina, Kourkoumelis, Christine, Kourlitis, Evangelos, Kouskoura, Vasiliki, Kowalewski, Robert Victor, Kowalewski, Bob, Kozanecki, Witold, Kozhin, Anatoli, Kramarenko, Viktor, Kramberger, Gregor, Krasnopevtsev, Dimitrii, Krasny, Mieczyslaw, Krasznahorkay, Attila, Krauss, Dominik, Kremer, Jakub, Kretzschmar, Jan, Kreul, Ken Matthias, Krieger, Peter, Krieter, Ferdinand, Krishnamurthy, Samyukta, Krishnan, Anjali, Krivos, Martin, Krizka, Karol, Kroeninger, Kevin Alexander, Kroha, Hubert, Kroll, Jiri, Kroll, Joseph Ira, Krowpman, Kyle Stuart, Kruchonak, Uladzimir, Krueger, Hans, Krumnack, Nils Erik, Kruse, Mark, Krzysiak, Janina Anna, Kubota, Arisa, Kuchinskaia, Olesia, Kuday, Sinan, Kuchler, Daniela, Kuechler, J.T., Kuehn, Susanne, Kuhl, Thorsten, Kukhtin, Victor, Kulchitsky, Y., Koultchitski, Iouri, Kuleshov, Sergey, Koultchitski, Yuri, Kuleshov, Serguei, Kulinich, Yakov Petrovich, Kuna, Marine, Kupco, Alexander, Kupfer, Tobias, Kuprash, Oleg, Kurashige, Hisaya, Kurchaninov, Leonid, Kurochkin, Yurii, Kurova, Anastasia, Kurth, Matthew Glenn, Kuwertz, Emma Sian, Kuze, Masahiro, Kvam, Audrey Katherine, Kvita, Jiri, Kwan, Tony, Lacasta Llacer, Carlos, Lacava, Francesco, Lack, David Philip John, Lacker, Heiko Markus, Lacour, Didier, Ladygin, Evgeny, Lai, Stanley Tsai-Ting, Ladygin, Evgueni, Lafaye, Remi, Laforge, Bertrand, Lagouri, Theodota, Lai, Stan, Lakomiec, Inga Katarzyna, Lambert, Joseph Earl, Lammers, Sabine Wedam, Lampl, Walter, Lampoudis, Christos, Lancon, Eric Christian, Landgraf, Ulrich, Landon, Murrough, Lang, Valerie, Lange, Joern, Langenberg, Robert Johannes, Lankford, Andrew James, Lanni, Francesco, Lantzsch, Kerstin, Lanza, Agostino, Lapertosa, Alessandro, Laporte, Jean-Francois, Lari, Tommaso, Lasagni Manghi, Federico, Lassnig, Mario, Latonova, Vera, Lau, Tak Shun, Laudrain, Antoine, Laurier, Alexandre, Lavorgna, Marco, Lawlor, Sean Dean, Lazzaroni, Massimo, Le, Brian, Le Guirriec, Emmanuel, Lebedev, Alexandre, Lecompte, T., Leblanc, Matthew Edgar, Le Compte, Thomas Joseph, Leblanc, Matt, Le Compte, Tom, Ledroit-Guillon, F., Lee, Ava Chloe Audrey, Lee, Claire, Lee, Graham Richard, Lee, Lawrence, Lee, Shih-Chang, Lee, Songkyo, Lefebvre, Benoit, Lefebvre, Helena, Lefebvre, Michel, Leggett, Charles, Lehmann, Konstantin, Lehmann, Niklaus, Lehmann Miotto, Giovanna, Leight, William Axel, Leisos, Antonios, Lisboa Leite, Marco, Leitgeb, Clara Elisabeth, Leitner, Rupert, Leney, Katharine, Lenz, Tatjana, Leone, Sandra, Leonidopoulos, Christos, Leopold, Alexander, Leroy, Claude, Les, Robert, Lester, Christopher, Levchenko, Mikhail, Leveque, Jessica, Levin, Daniel Sheldon, Lloyd, Stephen, Levin, Dan, Levinson, Lorne, Lewis, Daniel James, Li, Boyang, Li, Bing, Li, Changqiao, Li, Fan, Li, Heng, Li, Haifeng, Li, Jing, Li, Ke, Li, Liang, Li, Mengran, Li, Quanyin, Li, Shu, Li, Xingguo, Li, Yichen, Li, Zhi, Li, Zhiying, Li, Zhelun, Li, Zhiyuan, Liang, Zhijun, Liberatore, Marianna, Liberti, Barbara, Lie, Ki, Lim, Sanghoon, Lin, Chiao-Ying, Lin, Kuan-Yu, Linck, Rebecca, Lindley, Rachel Elizabeth, Lindon, Jack, Linss, Arthur, Lionti, Anthony, Lipeles, Elliot, Lipniacka, Anna, Liss, Anthony Michael, Lister, Alison, Little, Jared, Liu, Bo, Liu, Bingxuan, Liu, Hongbin, Liu, Jianbei, Liu, J.K. K., Liu, Kun, Liu, Minghui, Liu, Mingyi, Liu, Peilian, Liu, Xiaotian, Liu, Yi, Liu, Yang, Liu, Yanlin, Liu, Yanwen, Livan, Michele, Lleres, Annick, Llorente Merino, Javier, Luehring, Frederick, Lloyd, Steve, Lo, Cheuk Yee, Lobodzinska, Ewelina Maria, Loch, Peter, Loffredo, Salvatore, Lohse, Thomas, Lohwasser, Kristin, Lokajicek, Milos, Long, Jonathan, Long, Robin Eamonn, Longarini, Iacopo, Longo, Luigi, Lopez Paz, Ivan, Lopez Solis, Alvaro, Lorenz, Jeanette Miriam, Lorenzo Martinez, Narei, Lory, Alexander, Loesle, Alena, Lou, Xuanhong, Lou, Xinchou, Lounis, Abdenour, Love, Jeremy Robert, Love, Peter, Lozano Bahilo, Julio, Lu, Miaoran, Lu, Yun-Ju, Lubatti, Henry, Luci, Claudio, Lucio Alves, Fabio Lucio, Lucotte, Arnaud, Luehring, Fred, Luise, Ilaria, Luminari, Lamberto, Lund-Jensen, Bengt, Luongo, Nicholas, Lutz, Margaret Susan, Lynn, David, Lyons, Harry John, Lysak, Roman, Lytken, Else, Lyu, Feng, Lyubushkin, Vladimir, Lyubushkina, Tatiana, Ma, Hong, Ma, Lianliang, Ma, Yanhui, Donell, D.M. Mac, Macdonell, Danika Marina, Maccarrone, Giovanni, Macdonald, Calum Michael, Macdonald, Jack, Machado Miguens, Joana, Madar, Romain, Mader, Wolfgang, Madugoda Ralalage Don, Madhuranga, Madysa, Nico, Maeda, Junpei, Maeno, Tadashi, Maerker, Max, Magerl, Veronika, Magini, Nicolo, Magro, Jacopo, Mahon, Devin, Maidantchik, Carmen, Maio, Amelia, Maj, Klaudia, Majersky, Oliver, Majewski, Stephanie, Makida, Yasuhiro, Makovec, Nikola, Malaescu, Bogdan, Malecki, Pa., Malecki, Pawel, Maleev, Victor, Malek, Fairouz, Malito, Davide, Mallik, Usha, Malone, Claire, Maltezos, Stavros, Malyukov, Sergey, Mamuzic, Judita, Mancini, Giada, Mandalia, Jesal, Mandic, Igor, Manhaes de Andrade Filho, Luciano, Maniatis, Ioannis Michail, Ramos, J.Manjarres, Mankinen, Katja Hannele, Mann, Alexander, Manousos, Athanasios, Marshall, Zachary Louis, Martin, Timothy, Maslennikov, Aleksei, Mcfayden, Joshua Angus, Manousos, Thanos, Mansoulie, Bruno, Manthos, Ioannis, Manzoni, Stefano, Marantis, Alexandros, Marceca, Gino, Marchese, Luigi, Marchiori, Giovanni, Marcisovsky, Michal, Marcoccia, Lorenzo, Marcon, Caterina, Marjanovic, Marija, Mc Kay, Madalyn Ann, Mcpherson, Robert Anthony, Marshall, Zach, Martensson, M.U. F., Marti I Garcia, Salvador, Martin, Christopher Blake, Martin, Tim, Martin, Victoria, Martin Dit Latour, Bertrand, Martinelli, Luca, Martinez-Perez, Mario, Martinez Agullo, Pablo, Martinez Outschoorn, Verena Ingrid, Martin-Haugh, Stewart, Martoiu, Sorin, Martyniuk, Alex Christopher, Marzin, Antoine, Maschek, Stefan Raimund, Masetti, Lucia, Mashimo, Tetsuro, Mashinistov, Ruslan, Masik, Jiri, Maslennikov, Alexei, Massa, Lorenzo, Massarotti, Paolo, Mastrandrea, Paolo, Mastroberardino, Anna, Masubuchi, Tatsuya, Matakias, Dimitrios, Matic, Andrea, Matsuzawa, Nobuo, Mattig, Peter, Maurer, Julien, Macek, Bostjan, Maximov, Dmitriy, Mazini, Rachid, Maznas, Ioannis, Mazza, Simone Michele, Mc Gowan, John Patrick, Mc Kee, Shawn, Mccarthy, Thomas, Mccormack, William Patrick, Mcdonald, Emily Frances, Mcdonald, Millie, Mcdougall, Ashley Ellen, Mcfayden, Josh, Mchedlidze, Gvantsa, Mc Kay, Maddie, Mclean, Kayla, Mcmahon, Stephen, Mcnamara, Peter Charles, Mcnicol, Christopher John, Mcpherson, R.A., Mdhluli, Joyful Elma, Meadows, Zachary Alden, Meehan, Samuel Ross, Megy, Theo, Mehlhase, Sascha, Mehta, Andrew, Meirose, Bernhard, Melini, Davide, Mellado Garcia, Bruce, Mellenthin, Johannes, Melo, Matej, Meloni, Federico, Melzer, Alexander, Gouveia, E.D. Mendes, Mendes Jacques da Costa, Antonio Manuel, Meng, Huan Yu, Meng, Lingxin, Meng, Xiangting, Menke, Sven, Meoni, Evelin, Mergelmeyer, Sebastian, Merkt, Sebastian Andreas, Merlassino, Claudia, Mermod, Philippe, Merola, Leonardo, Meroni, Chiara, Merz, Garrett William, Meshkov, Oleg, Meshreki, John Kamal Rizk, Metcalfe, Jessica, Mete, Alaettin Serhan, Meyer, Christopher John, Meyer, Jean-Pierre, Michetti, Michele, Middleton, Robin, Mijovic, Liza, Mikenberg, George, Mikestikova, Marcela, Mikuz, Marko, Mildner, Hannes, Milic, Adriana, Milke, Christopher Don, Milke, Chris, Miller, David, Miller, Laura Stephanie, Milov, Alexander, Milstead, David Anthony, Minaenko, Andrei, Minashvili, Irakli, Mince, Laurynas, Mincer, Allen Irving, Mindur, Bartosz, Mineev, Mikhail, Minegishi, Yuji, Mino, Yuya, Mir Martinez, Lluisa Maria, Mironova, Maria, Mistry, Khilesh Pradip, Mitani, Takashi, Mitrevski, Jovan, Mitsou, Vasiliki, Mittal, Monika, Miu, Ovidiu, Miucci, Antonio, Miyagawa, Paul, Mizukami, Atsushi, Mjoernmark, Jan-Ulf, Mkrtchyan, Tigran, Mlynarikova, Michaela, Moa, Torbjorn, Mobius, Silke, Mochizuki, Kazuya, Moder, Paul, Mogg, Philipp, Mohapatra, Soumya, Moles Valls, Regina, Monig, Klaus, Monnier, Emmanuel, Montalbano, Alyssa Rae, Montejo Berlingen, Javier, Montella, Marco, Monticelli, Fernando, Monzani, Simone, Morange, Nicolas, Moreira de Carvalho, Ana Luisa, Moreno Lopez, Deywis, Moreno Llacer, Maria, Moreno Martinez, Carlos, Morettini, Paolo, Morgenstern, Marcus Matthias, Morgenstern, Stefanie, Mori, Daniel, Morii, Masahiro, Morinaga, Masahiro, Morisbak, Vanja, Morley, Anthony, Mornacchi, Giuseppe, Morris, Alice, Morvaj, Ljiljana, Moschovakos, Paraschos, Myers, Gregory William, Nachman, Benjamin Philip, Moschovakos, Paris, Moser, Brian, Mosidze, Maia, Moskalets, Tetiana, Moskvitina, Polina, Moss, Joshua, Moyse, E.J. W., Muanza, Steve, Mueller, James Alfred, Muller, Ralph, Muenstermann, Daniel, Mullier, Geoffrey, Mungo, Davide Pietro, Munoz Martinez, Jose Luis, Munoz Sanchez, Francisca, Murin, Pavel, Murray, William John, Murray, Bill, Murrone, Alessia, Muse, Joseph M, Muskinja, Miha, Mwewa, Chilufya, Myagkov, Alexei, Myers, Ava Anne, Neep, Thomas James, Ntekas, Konstantinos, Myers, Greg, Myers, John, Myska, Miroslav, Nachman, B.P., Nackenhorst, Olaf, Nag, Abhishek, Nagai, Koichi, Nagano, Kunihiro, Nagasaka, Yasushi, Nagle, James Lawrence, Nagy, Elemer, Nairz, Armin, Higuchi, Yu Nakahama, Nakamura, Koji, Nakamura, Tomoaki, Nanjo, Hajime, Napolitano, Fabrizio, Garcia, R.F. Naranjo, Narayan, Rohin Thampilali, Naryshkin, Iurii, Naseri, Mohsen, Naumann, Thomas, Navarro, Gabriela Alejandra, Nechaeva, Polina, Nechansky, Filip, Ng, Yan Wing, Neep, T.J., Negri, Andrea, Negrini, Matteo, Nellist, Clara, Nelson, Christina, Nelson, Michael Edward, Nemecek, Stanislav, Nessi, Marzio, Neubauer, Mark, Neuhaus, Friedemann, Neumann, Manuel, Newhouse, Robin, Newman, Paul Richard, Ng, Chi Wing, Nikolaidou, Rodanthi, Nilsson, Paal Nils Bertil, Ng, Sam Yanwing, Ng, Ying Wun Yvonne, Ngair, Badr-Eddine, Nguyen, Hoang Dai Nghia, Nguyen Manh, Tuan, Nibigira, Emery, Nickerson, Richard, Nikolaidou, Rosy, Nielsen, Daniel, Nielsen, Jason, Niemeyer, Marcel, Nikiforou, Nikiforos, Nikolaenko, Vladimir, Nikolic-Audit, I., Nikolopoulos, Konstantinos, Nilsson, Paul, Nindhito, Herjuno Rah, Nisati, Aleandro, Nishu, Nishu, Nisius, Richard, Nitsche, Isabel, Nitta, Tatsumi, Nobe, Takuya, Noel, Daniel Louis, Noguchi, Yohei, Nomidis, Ioannis, Nomura, Marcelo Ayumu, Nordberg, Markus, Novak, Jakob, Novak, Tadej, Novgorodova, Olga, Novotny, Radek, Nozka, Libor, Ntekas, Kostas, Nurse, Emily Laura, Oakham, Gerald, Ocariz, Jose Humberto, Ochi, Atsuhiko, Ochoa, Ines, Ochoa, Jean-Pierre, O'Connor, Kelsey Shea, Oda, Susumu, Odaka, Shigeru, Ordek, Serhat, Ogrodnik, Agnieszka Ewa, Oh, Alexander, Ohm, Christian, Oide, Hideyuki, Oishi, Reiyo, Ojeda, Martina Laura, Okawa, Hideki, Okazaki, Yuta, O'Keefe, Michael William, Okumura, Yasuyuki, Olariu, Albert, Seabra, L.F. Oleiro, Olivares, Sebastian, Oliveira Damazio, Denis, Oliver, Jason, Olsson, Mats Joakim Robert, Olszewski, Andrzej, Olszowska, Jolanta, Oncel, Omer Ogul, O'Neil, Dugan, O'Neill, Aaron Paul, Onofre, Antonio, Onyisi, P.U. E., Oppen, Henrik, Oreamuno Madriz, Rafael Guillermo, Oreglia, Mark, Orellana, Gonzalo Enrique, Orestano, Domizia, Orlando, Nicola, Orr, Robert, O'Shea, Valentine, Ouellette, Jeffrey Cortlandt, Parker, Andrew Michael, O'Shea, Val, Ospanov, Rustem, Otero y Garzon, Gustavo, Otono, Hidetoshi, Ott, Philipp Sebastian, Ottino, Gregory James, Ouchrif, Mohamed, Ouellette, Jeff, Ould-Saada, Farid, Ouraou, Ahmimed, Ouyang, Qun, Owen, Mark Andrew, Owen, Rhys, Ozcan, Erkcan, Ozturk, Nurcan, Pacalt, Josef, Pacey, Holly, Pachal, Katherine, Pacheco Pages, Andreu, Padilla Aranda, Cristobal, Pagan Griso, Simone, Palacino, Gabriel, Palazzo, Serena, Palestini, Sandro, Palka, Marek, Palni, Prabhakar, Pandini, Carlo Enrico, Panduro Vazquez, Jose Guillermo, Panduro Vazquez, William, Pani, Priscilla, Panizzo, Giancarlo, Paolozzi, Lorenzo, Papadatos, Constantine, Papageorgiou, Konstantinos, Parajuli, Santosh, Paramonov, Alexander, Paraskevopoulos, Christos, Paredes Hernandez, Daniela Katherinne, Paredes Saenz, Santiago Rafael, Parida, Bibhuti, Park, Tae Hyoun, Parker, Adam Jackson, Pollard, Christopher Samuel, Parker, Andy, Parodi, Fabrizio, Parrish, Elliot, Parsons, John, Parzefall, Ulrich, Pascual Dominguez, Luis, Pascuzzi, Vincent, Pasner, Jacob Martin, Pasquali, Federica, Pasqualucci, Enrico, Passaggio, Stefano, Pastore, Francesca, Pasuwan, Patrawan, Pataraia, Sophio, Pater, Joleen, Pater, Jo, Pathak, Atanu, Patton, Joseph, Pauly, Thilo, Pearkes, Jannicke Andree, Pedersen, Maiken, Pedraza Diaz, Lucia, Costa Batalha Pedro, Rute, Peiffer, Thomas, Peleganchuk, Sergey, Penc, Ondrej, Peng, Chen, Peng, Haiping, Sotto-Maior Peralva, Bernardo, Perego, Marta Maria, Pereira Peixoto, A.P., Pereira Sanchez, Laura, Perepelitsa, Dennis, Perez Codina, Estel, Perini, Laura, Pernegger, Heinz, Perrella, Sabrina, Perrevoort, Ann-Kathrin, Peters, Krisztian, Peters, Reinhild, Petersen, Brian, Petersen, Troels, Petit, Elisabeth, Petousis, Vlasios, Petridou, Chariclia, Petrucci, Fabrizio, Pettee, Mariel, Pettersson, Nora Emilia, Petukhova, Krystsina, Raine, John Andrew, Rajagopalan, Srinivasan, Mihule, Kristina, Peyaud, Alan, Pezoa Rivera, Raquel, Pezzotti, Lorenzo, Pham, Le Ha Thu, Pham, Joni, Phillips, Peter, Phipps, Michael William, Piacquadio, Giacinto, Pianori, Elisabetta, Picazio, Attilio, Pickles, Rebecca Hayley, Piegaia, Ricardo, Pietreanu, Dorel, Pilcher, James, Pilcher, Jim, Pilkington, Andrew, Pinamonti, Michele, Pinfold, James, Pitman Donaldson, Charlie Bruno, Pitt, Michael, Pizzimento, Luca, Pizzini, Alessio, Pleier, Marc-Andre, Plesanovs, Vladislavs, Pleskot, Vojtech, Plotnikova, Elena, Podberezko, Pavel, Pottgen, Ruth, Poggi, Riccardo, Poggioli, Luc, Pogrebnyak, Ivan, Pohl, David-Leon, Pokharel, Ishan, Polesello, Giacomo, Poley, Anne-Luise, Policicchio, Antonio, Polifka, Richard, Polini, Alessandro, Pollard, Chris, Polychronakos, Venetios, Ponomarenko, Daniil, Pontecorvo, Ludovico, Popa, Stefan, Popeneciu, Gabriel, Portales, Louis, Portillo Quintero, Dilia Maria, Pospisil, Stanislav, Potamianos, Karolos, Potrap, Igor, Potter, Christina Jane, Riu Dachs, Inmaculada, Potter, Tina, Potti, Harish, Poulsen, Trine, Poveda Torres, Joaquin, Poveda Torres, Ximo, Powell, Thomas Dennis, Pownall, Gavin, Pozo Astigarraga, Eukeni, Prades Ibanez, Alberto, Pralavorio, Pascal, Prapa, Maria Myrto, Prell, Soeren Andre, Price, Darren, Primavera, Margherita, Proffitt, Mason, Proklova, Nadezda, Prokofiev, Kirill, Prokoshin, Fedor, Protopopescu, Serbanp, Proudfoot, James, Przybycien, Mariusz, Pudzha, Dennis, Puri, Akshat, Puzo, Patrick Michel, Pyatiizbyantseva, Diana, Qian, Jianming, Qin, Yang, Qin, Quake, Quadt, Arnulf, Queitsch-Maitland, Michaela, Rabanal Bolanos, Gabriel, Racko, Michal, Ragusa, Francesco, Rahal, Ghita, Raine, Johnny, Rajagopalan, Srini, Ramirez Morales, Andres, Ran, Kunlin, Rassloff, Damir Fabrice, Rauch, Daniel, Rauscher, Felix, Rave, Stefan, Ravina, Baptiste, Ravinovich, Ilia, Rawling, Jacob Henry, Raymond, Michel, Read, Alexander Lincoln, Readioff, Nathan Peter, Reale, Marilea, Rebuzzi, Daniela, Redlinger, George, Reeves, Kendall, Reikher, David, Reiss, Andreas Dominik, Rej, Amartya, Rembser, Christoph, Renardi, Alessia, Renda, Michele, Rendel, Marian Benedikt, Rennie, Adam, Resconi, Silvia, Resseguie, Elodie Deborah, Rettie, Sebastien, Reynolds, Bryan, Reynolds, Elliot, Rezanova, Olga, Reznicek, Pavel, Ricci, Ester, Richter, Robert, Richter, Stefan, Richter-Was, Elzbieta, Ridel, Melissa, Rieck, Patrick, Rifki, Othmane, Rijssenbeek, Michael, Rimoldi, Adele, Rimoldi, Marco, Rinaldi, Lorenzo, Rinn, Timothy Thomas, Ripellino, Giulia, Ruiz Martinez, Maria Aranzazu, Riu, Imma, Rivadeneira Bracho, Pablo Andres, Rivera Vergara, Juan Cristobal, Rizatdinova, Flera, Rizvi, Eram Syed, Rizzi, Chiara, Robertson, Steven, Robin, Matthieu, Robinson, Dave, Robles Gajardo, Carolina Michel, Robles Manzano, Maria, Robson, Aidan, Rocchi, Alessandro, Roda, Chiara, Rodriguez Bosca, Sergi, Rodriguez Rodriguez, Arturo, Rodriguez Vera, Ana Maria, Roe, Shaun, Roggel, Jens, Rohne, Ole, Rohrig, Rainer, Rojas Caballero, Rimsky Alejandro, Roland, Benoit, Roland, Christophe Pol A, Roloff, Jennifer Kathryn, Romaniouk, Anatoli, Romano, Marino, Rompotis, Nikolaos, Ronzani, Manfredi, Roos, Lydia, Rosati, Stefano, Rosin, Guy, Rosser, Benjamin John, Rossi, Edoardo, Rossi, Eleonora, Rossi, Elvira, Rossi, Leonardo, Rossini, Lorenzo, Rosten, Rachel Christine, Rotaru, Marina, Rottler, Benjamin, Rousseau, David, Rovelli, Giulia, Roy, Avik, Roy, Debarati, Rozanov, Alexandre, Rozen, Yoram, Ruan, Xifeng, Salnikov, Andrey, Sampsonidis, Dimitrios, Ruan, Ruanxf, Ruggeri, Tristan Andrew, Rühr, F., Ruehr, Frederik, Ruiz Martinez, Arantxa, Rummler, Andre, Rurikova, Zuzana, Rusakovich, Nikolai, Russell, Heather, Rustige, Lennart, Rutherfoord, John P, Ruttinger, Elias, Rybar, Martin, Rybkin, Grigori, Rye, Eli Baverfjord, Ryzhov, Andrey, Sabater Iglesias, Jorge Andres, Sabatini, Paolo, Sabetta, Luigi, Sacerdoti, Sabrina, Sadrozinski, Hartmut, 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P., Schovancova, Jaroslava, Schramm, Steven, Schroeder, Frederic, Schulte, Alexandra, Schultz-Coulon, Hans-Christian, Schumacher, Markus, Schumm, Bruce Andrew, Schune, Ph., Schune, Philippe, Schwartzman, Ariel Gustavo, Schwarz, Thomas Andrew, Schwemling, Ph., Schwemling, Philippe, Schwienhorst, Reinhard, Sciandra, Andrea, Sciolla, Gabriella, Scuri, Fabrizio, Scutti, Federico, Scyboz, Ludovic Michel, Sebastiani, Cristiano, Sedlaczek, Kevin, Seema, Pienpen, Seidel, Sally, Seiden, Abraham, Seidlitz, Blair Daniel, Seiss, Todd Michael, Seitz, Claudia, Seixas, Jose, Sekhniaidze, Givi, Sekula, Stephen Jacob, Semprini Cesari, Nicola, Sen, Sourav, Serfon, Cedric, Serin, Laurent, Serkin, Leonid, Sessa, Marco, Severini, Horst, Sevova, Stanislava, Sforza, Federico, Sfyrla, Anna, Shabalina, Elizaveta, Shahinian, Jeffrey David, Shochet, Melvyn Jay, Sobie, Randall, Shahinian, Jeff, Shaikh, N.W., Ahlgren, Nabila Wahab, Shaked Renous, Dan, Shan, Lianyou, Shapiro, Marjorie, Sharma, Abhishek, Shatalov, Pavel, Shatalov, Sppavel, Shaw, Kate, Shaw, Savanna, Shehade, Mahran, Shen, Yu-Ting, Sherman, Alexander David, Sherwood, Peter, Shi, Liaoshan, Shimmin, Chase Owen, Shimogama, Yoshihiro, Shimojima, Makoto, Shinner, James David, Shipsey, I.P. J., Shirabe, Shohei, Shiyakova, Mariya, Shlomi, Jonathan, Shmeleva, Alevtina, Sivoklokov, Sergey, Shochet, M.J., Shojaii, J., Shojaii, Seyed Ruhollah, Shope, David Richard, Shrestha, Suyog, Shrif, Esra Mohammed, Shroff, Maheyer Jamshed, Shulga, Evgeny, Sicho, Petr, Sickles, Anne Marie, Sideras Haddad, Elias, Sidiropoulou, Ourania, Sidoti, Antonio, Siegert, Frank, Sijacki, Dj., Sijacki, Dorde, Silva, Manuel, Silva Oliveira, Marcos Vinicius, Silverstein, Samuel, Simion, Stefan, Simoniello, Rosa, Simpson-Allsop, Cameron James, Simsek, Sinem, Sinervo, Pekka, Sinetckii, Viktor, Singh, Sundeep, Sioli, Maximiliano, Siral, Ismet, Soffer, Abner, Sopio, Alexander Linus, Sivoklokov, Serguei, Sjoelin, Joergen, Skaf, Ali, Skorda, Eleni, Skubic, Patrick, Slawinska, Magdalena, Sliwa, Krzysztof Jan, Smakhtin, Vladimir, Smart, Ben Harry, Smiesko, Juraj, Smirnov, Nikita, Smirnov, Serge, Smirnov, Yury, Smirnova, Lidia, Smirnova, Oxana, Smith, Emily Ann, Smith, Hayden Alexander, Smizanska, Maria, Smolek, Karel, Smykiewicz, Andrzej, Snesarev, Andrei, Snoek, Hella, Snyder, Ian Michael, Snyder, Scott, Sobie, Randy, Soffer, Abi, Sogaard, Andreas, Sohns, Fabian, Solans Sanchez, Carlos, Soldatov, Evgeny, Soldevila Serrano, Urmila, Solodkov, Alexander, Solodkov, Sanya, Soloshenko, Aleksey, Solovyanov, Oleg, Solovyev, Victor, Sommer, Philip, Son, Hyungsuk, Sonay, Anil, Song, Weimin, Song, Wen Yi, Sopczak, Andre, Sopio, Alex, Sopkova, Filomena, Sottocornola, Simone, Soualah, Rachik, Sukharev, Andrei, South, David, Spagnolo, Stefania, Spalla, Margherita, Spangenberg, Martin, Spano, Francesco, Sperlich, Dennis, Spieker, Thomas Malte, Spigo, Giancarlo, Spina, Mario, Spiteri, Dwayne Patrick, Spousta, Martin, Stabile, Alberto, Stamas, Brianna, Stamen, Rainer, Stamenkovic, Marko, Stampekis, Alexios, Stanecka, Ewa, Stanislaus, Beojan, Stanitzki, Marcel, Stankaityte, Migle, Stapf, Birgit Sylvia, Starchenko, Evgeny, Stavropoulos, Georgios, Tikhonov, Yuriy, Starchenko, Jenya, Stark, Giordon Holtsberg, Stark, Jan, Staroba, Pavel, Starovoitov, Pavel, Staerz, Steffen, Staszewski, Rafal, Tokar, Stanislav, Stavropoulos, George, Stegler, Martin, Steinberg, Peter Alan, Steinhebel, Amanda, Stelzer, Bernd, Stelzer, Joerg, Stelzer-Chilton, Oliver, Stenzel, Hasko, Stevenson, Thomas James, Stewart, Graeme A, Stockton, Mark, Stoicea, Gabriel, Stolarski, Marcin, Stonjek, Stefan, Straessner, Arno, Strandberg, Jonas, Strandberg, Sara, Strauss, Michael George, Strauss, Mike, Strebler, Thomas, Strizenec, Pavol, Strohmer, Raimund, Strom, David, Stroynowski, Ryszard, Strubig, Antonia, Stucci, Stefania Antonia, Stugu, Bjarne, Stupak, John, Styles, Nicholas, Su, Dong, Su, Wanyun, Su, Xiaowen, Suarez, Nicholas Bruno, Sulin, Vladimir, Sullivan, Matthew James, Sultan, D.M. S., Sultanov, Salekh, Sultansoy, S., Sumida, Toshi, Sun, Siyuan, Sun, Xiaohu, Suster, Carl Joseph Edmund, Sutton, Mark, Suzuki, Shota, Svatos, Michal, Swiatlowski, Maximilian J, Swift, Stewart Patrick, Swirski, Thorben, Sydorenko, Alexander, Sykora, Ivan, Sykora, Martin, Sykora, Tomas, Ta, Duc Bao, Tackmann, Kerstin, Kinghorn-Taenzer, Joseph Peter, Taffard, Agnes Christine, Tsukerman, Ilya, Taffard, Anyes, Tafirout, Reda, Tagiev, Emin, Taibah, Reem Hani M, Takashima, Ryuichi, Takeda, Kosuke, Takeshita, Toru, Takeva, Emily Petrova, Takubo, Yosuke, Talby, Mossadek, Talyshev, Alexei, Tam, Kai Chung, Tamir, Nadav Michael, Tanaka, Junichi, Tanaka, Reisaburo, Tzamarias, Spyridon, Tanaka, Rei, Tapia Araya, Sebastian, Tapprogge, Stefan, Mohamed, A.Tarek Abouelfadl, Tarem, Shlomit, Tariq, Khuram, Tarna, Grigore, Tartarelli, Francesco, Tas, Petr, Tasevsky, Marek, Tassi, Enrico, Tateno, Gen, Tavares Delgado, Ademar, Tayalati, Yahya, Taylor, Alan James, Taylor, Geoffrey Norman, Taylor, Wendy Jane, Teagle, Hamish Edward, Tee, A.S., Teixeira de Lima, Rafael, Teixeira-Dias, Pedro, ten Kate, Herman, Teoh, Jia Jian, Terashi, Koji, Terron Cuadrado, Juan, Terzo, Stefano, Testa, Marianna, Teuscher, Richard, Thais, Savannah Jennifer, Themistokleous, Neofytos, Theveneaux-Pelzer, Timothee, Thomas, David William, Thomas, Juergen, Thompson, Emily Anne, Thompson, Paul, Thomson, Evelyn Jean, Thorpe, Edward James, Tikhomirov, Vladimiro, Tikhonov, Yu. A., Vacek, Vaclav, Tikhonov, Iouri, Timoshenko, Sergei, Tipton, Paul Louis, Tisserant, Sylvain, Todome, Kazuki, Todorova-Nova, S., Todt, Stefanie, Tojo, Junji, Tokar, Stano, Tokushuku, Katsuo, Tolley, Emma Elizabeth, Tombs, Rupert, Tomiwa, Kehinde Gbenga, Tomoto, Makoto, Tompkins, Lauren Alexandra, Tornambe, Peter, Torrence, Eric, Torres, Heberth, Torro Pastor, Emma, Toscani, Mariana, Tosciri, Cecilia, Toth, Jozsef, Tovey, Daniel, Traeet, Are Sivertsen, Treado, Colleen Jennifer, Trefzger, Thomas, Tresoldi, Fabio, Tricoli, Alessandro, Trigger, Isabel, Trincaz-Duvoid, Sophie, Trischuk, Dominique Anderson, Trischuk, William, Trocme, Benjamin, Trofymov, Artur, Troncon, Clara, Trovato, Fabrizio, Truong, Thi Ngoc Loan, Trzebinski, Maciej, Trzupek, Adam, Tsai, Fang-Ying, Tseng, Jeffrey, Tsiareshka, Pavel, Tsirigotis, Apostolos, Tsiskaridze, Vakhtang, Tskhadadze, Edisher, Tsopoulou, Maria-Evanthia, Tsukerman, Ilia, Tsulaia, Vakhtang, Tsuno, Soshi, Tsybyshev, Dmitry, Tu, Yanjun, Tudorache, Alexandra, Tudorache, Valentina, Tuna, Alexander Naip, Turchikhin, Semen, Turgeman, Daniel, Turk Cakir, Ilkay, Turner, Russell James, Turra, Ruggero, Tuts, Philip Michael, Tuts, Mike, Tzamarias, Spyros, Tzovara, Eftychia, Uchida, Kenta, Ukegawa, Fumihiko, Unal, Guillaume, Unal, Mesut, Undrus, Alexander, Unel, Gokhan, Ungaro, Francesca, Unno, Yoshinobu, Uno, Kenta, Urban, Josef, Urquijo, Phillip, Usai, Giulio, Uysal, Zekeriya, Vacek, Vic, Vachon, Brigitte, Vadla, Knut Oddvar Hoie, Vafeiadis, Theodoros, Vaidya, Amal, Valderanis, Chrysostomos, Valdes Santurio, Eduardo, Valente, Marco, Valentinetti, Sara, Valero Biot, Alberto, Valery, Loic, Vallance, Robert Adam, Vallier, Alexis, Valls Ferrer, Juan, van Daalen, Tal Roelof, van Gemmeren, Peter, van Stroud, Samuel, van Vulpen, Ivo, Vanadia, Marco, Vandelli, Wainer, Vandenbroucke, Maxence, Vandewall, E.R., van de Wall, Evan Richard, Vannicola, Damiano, Vari, Riccardo, Varnes, Erich Ward, Varni, Carlo, Varol, T., Mete, Tulin, Varouchas, Dimitris, Varvell, Kevin, Vasile, Matei, Vasquez, Gerardo, Vazeille, Francois, Vazquez Furelos, David, Vazquez Schroeder, Tamara, Veatch, Jason Robert, Vecchio, Valentina, Veen, Michiel Jan, Veloce, Laurelle Maria, Veloso, Filipe, Veneziano, Stefano, Ventura, Andrea, Verbytskyi, Andrii, Vercesi, Valerio, Verducci, Monica, Vergel Infante, Carlos Miguel, Vergis, Christos, Verkerke, Wouter, Vermeulen, Ambrosius Thomas, Vermeulen, Joseph, Vernieri, Caterina, Verschuuren, Pim Jordi, Vetterli, Michel Joseph, Viaux Maira, Nicolas, Vickey, Trevor, Vickey Boeriu, Oana, Viehhauser, G.H. A., Vigani, Luigi, Villa, Mauro, Perez, M.Villaplana, Villhauer, Elena Michelle, Vilucchi, Elisabetta, Vincter, Manuella, Virdee, Govindraj Singh, Vishwakarma, Akanksha, Vittori, Camilla, Vivarelli, Iacopo, Vogel, Marcelo, Vokac, Petr, von Ahnen, Janik, von Buddenbrock, Stefan, von Torne, Eckhard, Vorobel, Vit, Vorobev, Konstantin, Vos, Marcel, Vossebeld, Joost, Vozak, Matous, Vranjes, Nenad, Vranjes Milosavljevic, Marija, Vrba, Vaclav, Vreeswijk, Marcel, Vu, Ngoc Khanh, Vuillermet, Raphael, Vukotic, Ilija, Wada, Sayaka, Wagner, Peter, Wagner, Wolfgang, Wagner-Kuhr, Jeannine, Wahdan, Shayma, Wahlberg, Hernan Pablo, Wakasa, Rena, Walbrecht, Verena Maria, Walder, James William, Walker, Rodney, Walker, Stuart Derek, Walkowiak, Wolfgang, Wallangen, Veronica, Wang, Ann Miao, Wang, Alex Zeng, Wang, Chen, Wang, Chenliang, Wang, Haichen, Wang, Hulin, Wang, Jiawei, Wang, Peilong, Wang, Qing, Wang, Renjie, Wang, Rongkun, Wang, Rui, Wang, Song-Ming, Wang, Weitao, Wang, Wei, Wang, Wenxiao, Wang, Yufeng, Wang, Zirui, Wanotayaroj, Chaowaroj, Warburton, Andreas, Ward, Patricia, Ward, Robert James, Warrack, Neil, Watson, Alan, Watson, Miriam, Watts, Gordon, Waugh, Benedict Martin, Webb, Aaron, Weber, Christian, Weber, Michael Simon, Wells, Phillippa, Whalen, Kathleen Charlotte, Wyatt, Terence Richard, Weber, Michele, Weber, Stephen, Weber, Sebastian Mario, Wei, Yingjie, Weidberg, Anthony, Weingarten, Jens, Weirich, Marcel, Weiser, Christian, Wells, Pippa, Wenaus, Torre, Wendland, Bjoern, Wengler, Thorsten, Wenig, Siegfried, Wermes, Norbert, Wessels, Martin, Weston, Thomas, Whalen, Kate, Wharton, Andrew Mark, White, Aaron Stephen, White, Andrew, White, Martin John, Whiteson, Daniel, Whitmore, B.W., Wiedenmann, Werner, Wiel, Christian, Wielers, Monika, Wieseotte, Natalie, Wiglesworth, Craig, Wiik-Fuchs, L.A. 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L., Lasagni Manghi , F, Massa , L., Vittori , C., Alfonsi , F, Cabras , G., Cervelli , A., Negrini , M., Todome , K., Carratta , G., Cavalli , N., Clissa , L., ATLAS collaboration, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Aad, G. 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F., Zhang, G., Zhang, J., Zhang, K., Zhang, L., Zhang, M., Zhang, R., Zhang, S., Zhang, X., Zhang, Y., Zhang, Z., Zhao, P., Zhao, Y., Zhao, Z., Zhemchugov, A., Zheng, Z., Zhong, D., Zhou, B., Zhou, C., Zhou, H., Zhou, M., Zhou, N., Zhou, Y., Zhu, C. G., Zhu, C., Zhu, H. L., Zhu, H., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zhulanov, V., Zieminska, D., Zimine, N. I., Zimmermann, S., Zinonos, Z., Ziolkowski, M., Živković, L., Zobernig, G., Zoccoli, A., Zoch, K., Zorbas, T. G., Zou, R., Zwalinski, L., Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Atlas, Collaboration, and Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2936
Subjects: electron, Top quark, Kjerne- og elementærpartikkelfysikk: 431 [VDP], Physics and Astronomy (miscellaneous), 13000 GeV-cms, measured [channel cross section], Parton, pair production [top], 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), Subatomic Physics, scattering [p p], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], parton, associated production [Z0], Nuclear Experiment, Settore FIS/01, Physics, Luminosity (scattering theory), Large Hadron Collider, 4. Education, ATLAS, 16. Peace & justice, Nuclear and elementary particle physics: 431 [VDP], CERN LHC Coll, medicine.anatomical_structure, kinematics, colliding beams [p p], top: pair production, channel cross section: measured, Particle Physics - Experiment, data analysis method, p p: scattering, Particle physics, Z boson, CERN Lab, Regular Article - Experimental Physics, 530 Physics, FOS: Physical sciences, LHC, ATLAS, High Energy Physics, differential cross section: measured, Cross section (physics), Atlas (anatomy), measured [differential cross section], muon, 0103 physical sciences, medicine, ddc:530, High Energy Physics, 010306 general physics, Engineering (miscellaneous), top quark, Muon, hep-ex, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Física, leptonic decay [Z0], Z0: associated production, Z0: leptonic decay, LHC, Particle Physics, Top physics, High Energy Physics::Experiment, Hadron-hadron collisions, p p: colliding beams, experimental results, Lepton
Abstract: We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Au CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANIstralia; BMWFW and FWF, Austria; ANAXS, Azerbaijan; SSTC, Belarus;D, Chile; CAS, MOST and NSFC, China; Minciencias, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; JINR; MESofRussia andNRCKI, Russian Federation; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOEandNSF, USA. In addition, individual groups andmembers have received support fromBCKDF, CANARIE, ComputeCanada, CRC and IVADO, Canada; Beijing Municipal Science & Technology Commission, China; COST, ERC, ERDF, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), theY Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in Ref. [91]., Measurements of both the inclusive and differential production cross sections of a top-quark-antiquark pair in association with a Z boson (t (t) over barZ) are presented. The measurements are performed by targeting final states with three or four isolated leptons (electrons or muons) and are based on root s = 13 TeV proton-proton collision data with an integrated luminosity of 139 fb(-1), recorded from 2015 to 2018 with the ATLAS detector at the CERN Large Hadron Collider. The inclusive cross section is measured to be a sigma(t (t) over barZ)= 0.99 +/- 0.05 (stat.) +/- 0.08 (syst.) pb, in agreement with the most precise theoretical predictions. The differential measurements are presented as a function of a number of kinematic variables which probe the kinematics of the t (t) over barZ system. Both absolute and normalised differential crosssection measurements are performed at particle and parton levels for specific fiducial volumes and are compared with theoretical predictions at different levels of precision, based on a chi(2)/ndf and p value computation. Overall, good agreement is observed between the unfolded data and the predictions., CERN, ANPCyT, YerPhI, Armenia, Australian Research Council, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Natural Sciences and Engineering Research Council of Canada (NSERC), NRC, Canada, Canada Foundation for Innovation, SSTC, Belarus, Ministry of Education, Youth & Sports - Czech Republic Czech Republic Government, Czech Republic Government, DNRF, Denmark, Danish Natural Science Research Council, Centre National de la Recherche Scientifique (CNRS), CEA-DRF/IRFU, France, SRNSFG, Georgia, Federal Ministry of Education & Research (BMBF), HGF, Germany, Max Planck Society, Greek Ministry of Development-GSRT, RGC, China, Hong Kong SAR, China, Israel Science Foundation, Benoziyo Center, Israel, Istituto Nazionale di Fisica Nucleare (INFN), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science, CNRST, Morocco, Netherlands Organization for Scientific Research (NWO) Netherlands Government, RCN, Norway, Ministry of Science and Higher Education, Poland, NCN, Poland, Portuguese Foundation for Science and Technology European Commission, MNE/IFA, Romania, JINR, MESofRussia, Russian Federation, Ministry of Education, Science & Technological Development, Serbia, MSSR, Slovakia, Slovenian Research Agency - Slovenia, MIZS, Slovenia, DST/NRF, South Africa, Spanish Government, SRC, Sweden, Wallenberg Foundation, Sweden, SERI, Switzerland, Swiss National Science Foundation (SNSF), Cantons of Bern and Geneva, Switzerland, Ministry of Science and Technology, Taiwan, Ministry of Energy & Natural Resources - Turkey, UK Research & Innovation (UKRI) Science & Technology Facilities Council (STFC), DOEandNSF, USA, BCKDF, Canada, CANARIE, Canada, ComputeCanada, Canada, CRC, Canada, IVADO, Canada, Beijing Municipal Science & Technology Commission, COST, France, ERC, France, ERDF, France, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union, France, French National Research Agency (ANR), German Research Foundation (DFG), Alexander von Humboldt Foundation, Thales Group, Aristeia programmes, EU-ESF, Greece, Greek NSRF, Greece, BSF-NSF, Israel, German-Israeli Foundation for Scientific Research and Development, La Caixa Banking Foundation, Spain, CERCA Programme Generalitat de Catalunya, Spain, GenT Programmes Generalitat Valenciana, Spain, Goran Gustafssons Stiftelse, Sweden, Royal Society of London, Leverhulme Trust, BMWFW, Austria, Austrian Science Fund (FWF), Azerbaijan National Academy of Sciences (ANAS), D, Chile, Minciencias, Colombia
Published: 2021

31. Heterologous production and biochemical characterization of a new highly glucose tolerant GH1 β-glucosidase from Anoxybacillus thermarum

Author: José Carlos Santos Salgado, José Luis García, Maria de Lourdes Teixeira de Moraes Polizeli, Tássio Brito de Oliveira, Beatriz Galán, Malena M. Perez, Paula Zaghetto de Almeida, Rosymar Coutinho de Lucas, Fundação de Amparo à Pesquisa do Estado de São Paulo, Instituto Nacional de Ciência e Tecnologia do Bioetanol (Brasil), Oliveira, Tássio Brito de, Coutinho de Lucas, Rosymar, Santos Salgado, Jose Carlos, Galán, Beatriz, García, José Luis, Teixeira de Moraes Polizeli, Maria de Lourdes, Oliveira, Tássio Brito de [0000-0002-4666-7930], Coutinho de Lucas, Rosymar [0000-0001-8738-7372], Santos Salgado, Jose Carlos [0000-0002-3422-9474], Galán, Beatriz [0000-0002-2596-6034], García, José Luis [0000-0002-9238-2485], and Teixeira de Moraes Polizeli, Maria de Lourdes [0000-0002-5026-6363]
Subjects: chemistry.chemical_classification, BIOPROCESSOS, Thermophile, Lignocellulosic biomass, Substrate (chemistry), Glucose tolerance, Bioengineering, Cellobiose, Xylose, medicine.disease_cause, Applied Microbiology and Biotechnology, Biochemistry, Anoxybacillus thermarum, chemistry.chemical_compound, Hydrolysis, Enzyme, chemistry, β-glucosidase, Xylose tolerance, medicine, Escherichia coli
Abstract: The enzymatic lignocellulosic biomass conversion into value-added products requires the use of enzyme-rich cocktails, including β-glucosidases that hydrolyze cellobiose and cellooligosaccharides to glucose. During hydrolysis occurs accumulation of monomers causing inhibition of some enzymes; thus, glucose/xylose tolerant β-glucosidases could overcome this drawback. The search of new tolerant enzymes showing additional properties,such as high activity, wide-pH range, and thermal stability is very relevant to improve the bioprocess. We describe a novel β-glucosidase GH1 from the thermophilic Anoxybacillus thermarum (BgAt), which stood out by the robustness combination of great glucose/xylose tolerance, thermal stability, and high Vmax. The recombinant his-tagged-BgAt was overexpressed in Escherichia coli, was purified in one step, showed a high glucose/xylose tolerance, and activity stimulation (presence of 0.4M glucose/1.0M xylose). The optimal activity was at 65 °C - pH 7.0. BgAt presented an extraordinary temperature stability (48 h – 50 °C), and pH stability (5.5–8.0). The novel enzyme showed outstanding Vmax values compared to other β-glucosidases. Using p-nitrophenyl-β-D-glucopyranoside as substrate the values were Vmax (7614 U/mg), and KM (0.360 mM). These values suffer a displacement in Vmax to 14,026 U/mg (glucose), 14,886 U/mg (xylose), and KM 0.877mM (glucose), and 1.410mM (xylose)., This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, process no 2018/07522-6) and a scholarship to Tassio B. Oliveira (grant 2017/09000-4). MLTMP is a Research Fellow of Conselho de Desenvolvimento Científico e Tecnológico (CNPq, process 301963/2017-7). The project also received grants from National Institute of Science and Technology of Bioethanol,INCT, CNPq 465319/2014-9/FAPESP nº 2014/50884-5). PZA was a fellow from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) funding code 001 and Programa de Doutorado Sanduiche no Exterior, PDSE no 88881.135684/2016-01.
Published: 2020

32. The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2

Author: Aad, Georges, Abbott, Braden Keim, Abramowicz, Halina, Arce, Ayana Tamu, Han, Liangliang, Han, Liang, Han, Shuo, Han, Yi Fei, Hanagaki, Kazunori, Hance, Mike, Hank, Michael Donald, Hankache, Robert, Hansen, Eva Brottmann, Hansen, Jorgen Beck, Arguin, Jean-francois, Hansen, Dines, Hansen, Maike Christina, Hansen, Peter, Hanson, Emily Claire, Hara, Kazuhiko, Harenberg, Torsten, Harkusha, Siarhei, Harrison, Paul Fraser, Hartman, Nicole Michelle, Hartmann, Nikolai, Argyropoulos, Spyros, Hasegawa, Yoji, Hasib, Ahmed, Hassani, Samira, Haug, Sigve, Hauser, Reiner, Havranek, Miroslav, Hawkes, Chris, Hawkings, Richard, Hayashida, Shota, Hayden, Daniel, Arling, Jan-hendrik, Hayes, Christopher Robyn, Hayes, Robin, Hays, Chris, Hays, Jonathan, Hayward, Helen, Haywood, Stephen, He, Fudong, He, Yunjian, Heath, Matthew Peter, Hedberg, Vincent, Armbruster, Aaron James, Heggelund, Andreas Lokken, Hehir, Natasha, Heidegger, Constantin, Heidegger, Kim Katrin, Heidorn, William Dale, Heilman, Jesse Alan, Heim, Sarah, Heim, Timon, Heinemann, Beate, Heinlein, James Geddy, Armstrong, Alexander, Heinrich, Jochen Jens, Heinrich, Lukas Alexander, Hejbal, Jiri, Helary, Louis, Held, Alexander, Hellesund, Simen, Helling, Cole Michael, Hellman, Sten, Helsens, Clement, Henderson, R. C. W., Arnaez, Olivier, Henkelmann, Lars, Henriques Correia, Ana Maria, Herde, Hannah Elizabeth, Hernandez Jimenez, Yesenia, Herr, Holger Arnold, Herrmann, Maximilian Georg, Herrmann, Tim, Herten, Gregor, Hertenberger, Ralf, Hervas, Luis, Arnold, Hannah, Hessey, Nigel, Hibi, Hiroaki, Higashino, Satoshi, Higon-rodriguez, Emilio, Hildebrand, Kevin, Hill, John, Hill, Kurt Keys, Hiller, Karlheinz, Hillier, Stephen, Hils, Maximilian, Arrubarrena Tame, Zulit Paola, Hinchliffe, Ian, Hinterkeuser, Florian, Hirose, Minoru, Hirose, Shigeki, Hirschbuehl, Dominic, Hiti, Bojan, Hladik, Ondrej, Hobbs, John David, Hobincu, Radu, Tal Hod, Noam, Artoni, Giacomo, Hodgkinson, Mark, Hoecker, Andreas, Hohn, David, Hohov, Dmytro, Holm, Tanja, Holmes, Tova, Holzbock, Michael, Hommels, L. B. A. H., Hong, Tae Min, Honig, Jan Cedric, Abreu, Henso, Asada, Haruka, Honle, Andreas, Hooberman, Benjamin Henry, Hopkins, Walter, Horii, Yasuyuki, Horn, Philipp, Horyn, Lesya Anna, Hou, Suen, Howarth, James William, Hoya, Joaquin, Hrabovsky, Miroslav, Asai, Kanae, Hrynevich, Aliaksei, Hrynova, Tetiana, Manousos, Thanos, Mcdonald, Millie, Mc Kay, Maddie, Murray, Bill, Panduro Vazquez, William, Mihule, Kristina, Pham, Joni, Hsu, Shih-chieh, Asai, Shoji, Hu, Qipeng, Hu, Shuyang, Hu, Yifan, Huang, Danping, Huang, Xiaozhong, Huang, Yicong, Huang, Yanping, Hubacek, Zdenek, Hubaut, Fabrice, Hubner, Michael, Asawatavonvanich, Thanawat, Huegging, Fabian, Huffman, Todd Brian, Huhtinen, Mika, Hulsken, Raphael, Hunter, Robert Francis, Huseynov, Nazim, Huston, Joey, Huth, John, Hyneman, Rachel Jordan, Hyrych, Sofiia, Asbah, Nedaa Alexandra, Iacobucci, Giuseppe, Iakovidis, George, Ibragimov, Iskander, Iconomidou-fayard, Lydia, Iengo, Paolo, Ignazzi, Rosanna, Iguchi, Ryunosuke, Iizawa, Tomoya, Ikegami, Yoichi, Ilg, A., Asimakopoulou, Eleni Myrto, Ilic, Nikolina, Imam, Hajar, Introzzi, Gianluca, Iodice, Mauro, Iordanidou, Kalliopi, Ippolito, Valerio, Isacson, Max Fredrik, Ishino, Masaya, Islam, Wasikul, Issever, Cigdem, Asquith, Lily, Istin, Serhat, Ponce, J. M. Iturbe, Iuppa, Roberto, Ivina, Anna, Izen, Joseph Michael, Izzo, Vincenzo, Jacka, Petr, Jackson, Paul, Jacobs, Ruth Magdalena, Jaeger, Benjamin Paul, Assahsah, Jihad, Jakel, Gunnar, Jakobi, Katharina Bianca, Jakobs, Karl, Jakoubek, Tomas, Jamieson, Jonathan, Janas, Krzysztof, Jansky, Roland, Janus, Piotr Andrzej, Jarlskog, Goran, Jaspan, Adam Elliott, Assamagan, Ketevi Adikle, Javadov, Namig, Javurek, Tomas, Javurkova, Martina, Jeanneau, Fabien, Jeanty, Laura, Jejelava, Juansher, Jenni, Peter, Jezequel, Stephane, Jia, Jiangyong, Jia, Zihang, Astalos, Robert, Jiang, Yi, Jiggins, Stephen, Jimenez Morales, Fabricio Andres, Jimenez Pena, Javier, Jin, Shan, Jinaru, Adam, Jinnouchi, Osamu, Jivan, Harshna, Johansson, Per Daniel Conny, Johns, Kenneth, Abulaiti, Yiming, Atkin, Ryan Justin, Johnson, Christian, Jones, Eleanor, Jones, R. W. L., Jones, Samuel David, Jones, T. J., Jovicevic, Jelena, Ju, Xiangyang, Junggeburth, Johannes Josef, Juste Rozas, Aurelio, Kaczmarska, Anna, Atkinson, Markus Julian, Kado, Marumi, Kagan, Harris, Kagan, Michael Aaron, Kahn, Alan Mathew, Kahra, Christian, Kaji, Toshiaki, Kajomovitz Must, Enrique, Kalderon, Will, Kaluza, Adam, Kamenshchikov, Andrey, Atlay, Naim Bora, Kaneda, Michiru, Kang, Nathan Jihoon, Kang, Shuaiyan, Kano, Yuya, Kanzaki, Junichi, Kar, Deepak, Karava, Kla, Kareem, Mohammad, Karkanias, Ioannis, Karpov, Sergey, Atmani, Hicham, Karpova, Zoya, Kartvelishvili, Vato, Karyukhin, Andrei, Kasimi, Eirini, Kato, Chikuma, Katzy, Judith, Kawade, Kentaro, Kawagoe, Kiyotomo, Kawaguchi, Tomomi, Kawamoto, Tatsuo, Atmasiddha, Prachi, Kawamura, Gen, Kay, Ellis, Kaya, F. I., Kazakos, Stergios, Kazanin, Vassili, Ke, Yan, Keaveney, James Michael, Keeler, Richard, Keller, John Stakely, Kelsey, Daniel Christopher, Augsten, Kamil, Kempster, Jacob Julian, Kendrick, James Andrew, Kennedy, Kiley Elizabeth, Kepka, Oldrich, Kersten, Susanne, Kersevan, Borut Paul, Haghighat, S. Ketabchi, Khalil-zada, Farhad, Khandoga, Mykola, Khanov, Alexander, Austrup, Volker Andreas, Kharlamov, Alexey, Kharlamova, Tatyana, Khoda, Elham E, Khoo, Teng Jian, Khoriauli, Gia, Khramov, Evgeny, Khubua, J., Kido, Shogo, Kiehn, Moritz, Kilgallon, Aaron Joseph, Avolio, Giuseppe, Kim, Eunchong, Kim, Young-kee, Kimura, Naoki, Kirchhoff, Andreas, Kirchmeier, David, Kirk, Julie, Kiryunin, Andrei, Kishimoto, Tomoe, Kisliuk, Dylan Perry, Kitali, Vincent, Ayoub, Mohamad Kassem, Kitsaki, Chara, Kivernyk, Oleh, Klapdor-kleingrothaus, Thorwald, Klassen, Martin, Klein, Christoph Thomas, Klein, Lucas, Klein, Matthew Henry, Klein, Max, Klein, Uta, Klimek, Pawel Jan, Azuelos, Georges, Klimentov, Alexei, Klimpel, Fabian, Klingl, Tobias, Klioutchnikova, Tatiana, Klitzner, Felix Fidelio, Kluit, Peter, Kluth, Stefan, Kneringer, Emmerich, Knue, Andrea Helen, Kobayashi, Dai, Acharya, Bobby Samir, Babal, Dominik, Kobel, Michael, Kocian, Martin, Kodama, Takafumi, Kodys, Peter, Koeck, D. M., Konig, Philipp, Koffas, Thomas, Koehler, Nicolas, Kolb, Mathis, Koletsou, Iro, Bachacou, Henri, Komarek, Tomas, Koeneke, Karsten, Kong, A. X. Y., Kono, Takanori, Konstantinides, Vasilis, Konstantinidis, Nikolaos, Konya, Balazs, Kopeliansky, Revital, Koperny, Stefan Zenon, Korcyl, Krzysztof Marian, Bachas, Dinos, Kordas, Kostas, Koren, Guy, Korn, Andreas, Korolkov, Ilya, Korolkova, Elena, Korotkova, Natalia, Kortner, Oliver, Kortner, Sandra, Kostyukhin, Vadim, Kotsokechagia, Anastasia, Bachas, K., Kotwal, Ashutosh, Koulouris, Aimilianos, Kourkoumeli-charalampidi, Athina, Kourkoumelis, Christine, Kourlitis, Evangelos, Kowalewski, R., Kozanecki, Witold, Kozhin, Anatoli, Kramarenko, Viktor, Kramberger, Gregor, Backman, Karl Filip, Krasnopevtsev, Dimitrii, Krasny, Mieczyslaw, Krasznahorkay, Attila, Kremer, Jakub, Kretzschmar, Jan, Kreul, Ken Matthias, Krieger, Peter, Krieter, Ferdinand, Krishnamurthy, Samyukta, Krishnan, Anjali, Bagnaia, Paolo, Krivos, Martin, Krizka, Karol, Kroeninger, Kevin Alexander, Kroha, Hubert, Kroll, Jiri, Kroll, Joseph Ira, Krowpman, Kyle Stuart, Kruchonak, Uladzimir, Krueger, Hans, Krumnack, Nils Erik, Bahrasemani, Sina, Kruse, Mark, Krzysiak, Janina Anna, Kubota, Arisa, Kuchinskaia, Olesia, Kuday, Sinan, Kuchler, Daniela, Kuechler, J. 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K., Liu, Kun, Adam, Lennart, Balli, Fabrice, Liu, Minghui, Liu, Mingyi, Liu, Peilian, Liu, Xiaotian, Liu, Yi, Liu, Yang, Liu, Yanlin, Liu, Yanwen, Livan, Michele, Lleres, Annick, Balunas, William Keaton, Llorente Merino, Javier, Lloyd, Steve, Lobodzinska, Ewelina Maria, Loch, Peter, Loffredo, Salvatore, Lohse, Thomas, Lohwasser, Kristin, Lokajicek, Milos, Long, Jonathan, Long, Robin Eamonn, Balz, Johannes, Longarini, Iacopo, Longo, Luigi, Longo, Riccardo, Lopez Paz, Ivan, Lopez Solis, Alvaro, Lorenz, Jeanette Miriam, Lorenzo Martinez, Narei, Lory, Alexander, Loesle, Alena, Lou, Xuanhong, Banas, Elzbieta, Lou, Xinchou, Lounis, Abdenour, Love, Jeremy Robert, Love, Peter, Lozano Bahilo, Julio, Lu, Miaoran, Lu, Sicong, Lu, Yun-ju, Lubatti, Henry, Luci, Claudio, Bandieramonte, Marilena, Lucio Alves, Fabio Lucio, Lucotte, Arnaud, Luehring, Fred, Luise, Ilaria, Luminari, Lamberto, Lund-jensen, Bengt, Luongo, Nicholas, Lutz, Margaret Susan, Lynn, David, Lyons, Harry John, Bandyopadhyay, Anjishnu, Lysak, Roman, Lytken, Else, Lyu, Feng, Lyubushkin, Vladimir, Lyubushkina, Tatiana, Ma, Hong, Ma, Lianliang, Ma, Yanhui, Donell, D. 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A., Martin, Victoria, Martin Dit Latour, Bertrand, Martinelli, Luca, Martinez-perez, Mario, Martinez Agullo, Pablo, Martinez Outschoorn, Verena Ingrid, Martin-haugh, Stewart, Martoiu, Sorin, Barillari, Teresa, Martyniuk, Alex Christopher, Marzin, Antoine, Maschek, Stefan Raimund, Masetti, Lucia, Mashimo, Tetsuro, Mashinistov, Ruslan, Masik, Jiri, Maslennikov, Alexei, Massa, Lorenzo, Massarotti, Paolo, Barisits, Martin, Mastrandrea, Paolo, Mastroberardino, Anna, Masubuchi, Tatsuya, Matakias, Dimitrios, Mathisen, Thomas, Matic, Andrea, Matsuzawa, Nobuo, Maurer, Julien, Macek, Bostjan, Maximov, Dmitriy, Barkeloo, Jason Tyler Colt, Mazini, Rachid, Maznas, Ioannis, Mazza, Simone Michele, Mc Ginn, Christopher, Mc Gowan, John Patrick, Mc Kee, Shawn, Mccarthy, Thomas, Mccormack, William Patrick, McDonald, E. F., Mcdougall, Ashley Ellen, Barklow, Tim, Mcfayden, Josh, Mchedlidze, Gvantsa, McKay, M. 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Mendes, Barnett, Michael, Mendes Jacques Da Costa, Antonio Manuel, Meng, Huan Yu, Meng, Lingxin, Menke, Sven, Meoni, Evelin, Mergelmeyer, Sebastian, Merkt, Sebastian Andreas, Merlassino, Claudia, Mermod, Philippe, Merola, Leonardo, Barnovska-Blenessy, Z., Meroni, Chiara, Merz, Garrett William, Meshkov, Oleg, Meshreki, John Kamal Rizk, Metcalfe, Jessica, Mete, Alaettin Serhan, Meyer, Christopher John, Meyer, Jean-pierre, Michetti, Michele, Middleton, Robin, Baroncelli, A., Mijovic, Liza, Mikenberg, George, Mikestikova, Marcela, Mikuz, Marko, Mildner, Hannes, Milic, Adriana, Milke, Chris, Miller, David, Miller, Laura Stephanie, Milov, Alexander, Adamczyk, Leszek, Baroncelli, Toni, Milstead, David Anthony, Minaenko, Andrei, Minashvili, Irakli, Mince, Laurynas, Mincer, Allen Irving, Mindur, Bartosz, Mineev, Mikhail, Minegishi, Yuji, Mino, Yuya, Mir Martinez, Lluisa Maria, Barone, Gaetano, Mironova, Maria, Mitani, Takashi, Mitrevski, Jovan, Mitsou, Vasiliki, Mittal, Monika, Miu, Ovidiu, Miucci, Antonio, Miyagawa, Paul, Mizukami, Atsushi, Mjoernmark, Jan-ulf, Barr, Alan, Mkrtchyan, Tigran, Mlynarikova, Michaela, Moa, Torbjorn, Mobius, Silke, Mochizuki, Kazuya, Moder, Paul, Mogg, Philipp, Mohapatra, Soumya, Mokgatitswane, Gaogalalwe, Mondal, Buddhadeb, Barranco Navarro, Laura, Mondal, Santu, Monig, Klaus, Monnier, Emmanuel, Montalbano, Alyssa Rae, Montejo Berlingen, Javier, Montella, Marco, Monticelli, Fernando, Morange, Nicolas, Moreira De Carvalho, Ana Luisa, Moreno Llacer, Maria, Barreiro Alonso, Fernando, Moreno Martinez, Carlos, Morettini, Paolo, Morgenstern, Marcus Matthias, Morgenstern, Stefanie, Mori, Daniel, Morii, Masahiro, Morinaga, Masahiro, Morisbak, Vanja, Morley, Anthony, Morris, Alice, Barreiro Guimaraes Da Costa, Joao, Morvaj, Ljiljana, Moschovakos, Paris, Moser, Brian, Mosidze, Maia, Moskalets, Tetiana, Moskvitina, Polina, Moss, Joshua, Moyse, E. 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F. Oleiro, Olivares, Sebastian, Oliveira Damazio, Denis, Oliver, Jason, Basson, Candice Ruth, Olsson, Mats Joakim Robert, Olszewski, Andrzej, Olszowska, Jolanta, Oncel, Omer Ogul, O'neil, Dugan, O'neill, Aaron Paul, Onofre, Antonio, Onyisi, P. U. E., Oppen, Henrik, Oreamuno Madriz, Rafael Guillermo, Bates, Richard, Oreglia, Mark, Orellana, Gonzalo Enrique, Orestano, Domizia, Orlando, Nicola, Orr, Robert, O'shea, Val, Ospanov, Rustem, Otero Y Garzon, Gustavo, Otono, Hidetoshi, Ott, Philipp Sebastian, Batlamous, Souad, Ottino, Gregory James, Ouchrif, Mohamed, Ouellette, Jeff, Ould-saada, Farid, Ouraou, Ahmimed, Ouyang, Qun, Owen, Mark Andrew, Owen, Rhys, Ozcan, Erkcan, Ozturk, Nurcan, Adelman, Jahred, Batley, Richard, Pacalt, Josef, Pacey, Holly, Pachal, Katherine, Pacheco Pages, Andreu, Padilla Aranda, Cristobal, Pagan Griso, Simone, Palacino, Gabriel, Palazzo, Serena, Palestini, Sandro, Palka, Marek, Batool, Binish, Palni, Prabhakar, Panchal, D. K., Pandini, Carlo Enrico, Vazquez, J. 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P. C., Sannino, Mario, Sano, Yuta, Sansoni, Andrea, Santoni, Claudio, Santos, Helena, Adye, Tim, Beloborodov, Konstantin, Santpur, Sai Neha, Santra, Arka, Saoucha, Kamal, Sapronov, Andrey, Mendes Saraiva, Joao Gentil, Schaffer, R. D., Sardain, J., Sasaki, Osamu, Sato, Koji, Sauerburger, Frank, Belotskiy, Konstantin, Sauvan, Emmanuel, Savard, Pierre, Sawada, Ryu, Sawyer, Craig Anthony, Sawyer, Lee, Sayago Galvan, Ivan, Sbarra, Carla, Sbrizzi, Antonio, Scanlon, Timothy Paul, Schaarschmidt, Jana, Belyaev, Nikita, Schacht, Peter, Schaefer, Douglas Michael, Schaefer, Leigh Catherine, Schaefer, Uli, Schaffer, A. C., Schaile, Dorothee, Schamberger Jr, Robert Dean, Schanet, Eric, Scharf, Christian, Scharmberg, Nicolas, Benchekroun, Driss, Chtcheguelski, Valery, Schegelsky, V. A., Scheirich, Daniel, Schenck, Ferdinand, Schernau, Michael, Schiavi, Carlo, Schildgen, Lara Katharina, Schillaci, Zachary Michael, Schioppa, Enrico Junior, Schioppa, Marco, Benekos, Nectarios, Schleicher, Katharina, Schlenker, Stefan, Schmidt-sommerfeld, Korbinian Ralf, Schmieden, Kristof, Schmitt, Christian, Schmitt, Stefan, Schoeffel, Laurent Olivier, Schoening, Andre, Scholer, Patrick, Schopf, Elisabeth, Benhammou, Yan, Schott, Matthias, Schouwenberg, J. F. 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W., Wiedenmann, Werner, Wiel, Christian, Wielers, Monika, Wieseotte, Natalie, Wiglesworth, Craig, Wiik-Fuchs, L. A. M., Wilkens, Henric, Blazek, Tomas, Wilkins, Lewis, Williams, Daniel, Williams, Hugh, Williams, Sarah Louise, Willocq, Stephane, Windischhofer, Philipp, Wingerter, Isabelle, Winkels, Emma, Winklmeier, Frank, Winter, Benedict Tobias, Bloch, Ingo, Wittgen, Matthias, Wobisch, Markus, Wolf, Anton, Woelker, Ricardo, Wollrath, Julian, Wolter, Marcin, Wolters, Helmut, Wong, Vincent Wai Sum, Wongel, Alicia, Woods, Natasha Lee, Blocker, Craig, Worm, Steven, Wosiek, Barbara Krystyna, Wozniak, Krzysztof Wieslaw, Wraight, Kenneth Gibb, Wu, Sau Lan, Wu, Xin, Wu, Yusheng, Wurzinger, Jonas, Wyatt, Terry, Wynne, Benjamin Michael, Blue, Andrew James, Xella, Stefania, Xiang, Jianhuan, Xiao, Xiong, Xie, Xiangyu, Xiotidis, Ioannis, Xu, Da, Xu, Hanlin, Xu, Hao, Xu, Lailin, Xu, Riley, Blumenschein, Ulla, Xu, Tairan, Xu, Wenhao, Xu, Yue, Xu, Zhongyukun, Xu, Zijun, Yabsley, Bruce Donald, Yacoob, Sahal, Yallup, David, Yamaguchi, Naoki, Yamaguchi, Yohei, Aggarwal, Anamika, Blumenthal, J., Yamatani, Masahiro, Yamauchi, Hiroki, Yamazaki, Tomohiro, Yamazaki, Yuji, Yan, Jun, Yan, Zhen, Yang, Haijun, Yang, Hongtao, Yang, Siqi, Yang, Tianyi, Bobbink, Gerjan, Yang, Xiao, Yang, Xuan, Yang, Yi-lin, Yang, Zhe, Yao, Wei-ming, Yap, Yee Chinn, Ye, Hanfei, Ye, Jingbo, Ye, Shuwei, Yeletskikh, Ivan, Bobrovnikov, Viktor, Yexley, Melissa, Yin, Pengqi, Yorita, Kohei, Yoshihara, Keisuke, Young, Christopher, Young, Charlie, Yuan, Rui, Yue, Xiaoguang, Zaazoua, Mohamed, Zabinski, Bartlomiej Henryk, Bogavac, Danijela, Zacharis, Georgios, Zaffaroni, Ettore, Zahreddine, Jad, Zaytsev, Alexandre, Zakareishvili, Tamar, Zakharchuk, Nataliia, Zambito, Stefano, Zanzi, Daniele, Zeissner, Sonja Verena, Zeitnitz, Christian, Bogdanchikov, Alexander, Zemaityte, Gabija, Zeng, Jiancong, Zenin, Oleg, Zenis, Tibor, Zenz, Seth, Zerradi, Soufiane, Zerwas, Dirk, Zgubic, Miha, Zhang, Bowen, Zhang, Dengfeng, Bohm, Christian, Zhang, Gang, Zhang, Jinlong, Zhang, Kaili, Zhang, Lei, Zhang, Liqing, Zhang, Matt, Zhang, Rui, Zhang, Shuzhou, Zhang, Xiangke, Zhang, Xueyao, Boisvert, Veronique, Zhang, Yu, Zhang, Zhiqing Philippe, Zhao, Pingchuan, Zhao, Yuzhan, Zhao, Zhengguo, Zhemchugov, Alexey, Zheng, Zhi, Zhong, Dewen, Zhou, Bing, Zhou, Chen, Bokan, Petar, Zhou, Hao, Zhou, Mingliang, Zhou, Ning, Zhou, You, Zhu, Chengguang, Zhu, Chenzheng, Zhu, Heling, Zhu, Hongbo, Zhu, Junjie, Zhu, Yingchun, Bold, Tomasz, Zhuang, Xuai, Zhukov, Konstantin, Zhulanov, Vladimir, Zieminska, Daria, Zimine, Nikolai, Zimmermann, Stephanie Ulrike, Zinonos, Zinonas, Ziolkowski, Michal, Zivkovic, Lidija, Zoccoli, Antonio, Bomben, Marco, Zoch, Knut, Zorbas, Theodore, Zou, Rui, Zou, Wenkai, Zwalinski, Lukasz, ATLAS Collaboration, Agheorghiesei, Catalin, Bona, Marcella, Bonilla, Johan Sebastian, Boonekamp, Maarten, Booth, Callum Dale, Borbely, Albert Gyorgy, Borecka-bielska, Hanna Maria, Borgna, Lucas Santiago, Borisov, Anatoli, Borissov, Guennadi, Bortoletto, Daniela, Abed Abud, Adam, Aguilar Saavedra, Juan Antonio, Boscherini, Davide, Fernandez-bosman, Martine, Sola, J. D. Bossio, Bouaouda, Khalil, Boudreau, Joseph, Bouhova-Thacker, E. V., Boumediene, Djamel Eddine, Bouquet, Romain, Boveia, Antonio, Boyd, Jamie, Ahmad, Ammara, Boye, Diallo, Boyko, Igor, Bozson, Adam, Bracinik, Juraj, Brahimi, Nihal, Brandt, Gerhard Immanuel, Brandt, Oleg, Braren, Frued Erik, Brau, Benjamin Paul, Brau, J. E., Ahmadov, Faig, Breaden Madden, Will, Brendlinger, Kurt, Schimmel Brener, Roy, Brenner, Lydia, Brenner, Richard, Bressler, Shikma, Brickwedde, Bernard, Briglin, Daniel Lawrence, Britton, David, Britzger, Daniel Andreas, Ahmed, Waleed Syed, Brock, Ian, Brock, Raymond, Brooijmans, Gustaaf, Brooks, William King, Brost, Elizabeth, Bruckman De Renstrom, Pawel, Bruers, Ben, Bruncko, Dusan, Bruni, Alessia, Bruni, Graziano, Ai, Xiaocong, Bruschi, Marco, Bruscino, Nello, Bryngemark, Lene Kristian, Buanes, Trygve, Buat, Quentin, Buchholz, Peter, Buckley, Andy, Budagov, Ioulian, Bugge, Magnar Kopangen, Bulekov, Oleg, Aielli, Giulio, Bullard, Brendon, Burch, Tyler James, Burdin, Sergey, Burgard, Carsten Daniel, Burger, Angela Maria, Burghgrave, Blake Oliver, Burr, J. T. P., Burton, Charles, Burzynski, Jackson Carl, Buescher, Volker, Akatsuka, Shunichi, Buschmann, Eric, Bussey, Peter John, Butler, John Mark, Buttar, Craig, Butterworth, Jonathan, Buttinger, Will, Buxo Vazquez, Carlos Josue, Buzykaev, Alexey, Cabras, Grazia, Cabrera Urban, Susana, Akbiyik, Melike, Caforio, Davide, Cai, Huacheng, Cairo, Valentina, Cakir, Orhan, Calace, Noemi, Calafiura, Paolo, Calderini, Giovanni, Calfayan, Philippe, Callea, Giuseppe, Caloba, Luiz, Akesson, Torsten, Caltabiano, Alessandro, Calvente Lopez, Sergio, Calvet, David, Calvet, Samuel, Calvet, Thomas Philippe, Calvetti, Milene, Camacho Toro, Reina Coromoto, Camarda, Stefano, Camarero Munoz, Daniel, Camarri, Paolo, Akilli, Ece, Camerlingo, Maria Teresa, Cameron, David, Camincher, Clement, Campanelli, Mario, Camplani, Alessandra, Canale, Vincenzo, Canesse, Auriane, Bret Cano, Marc, Cantero Garcia, Josu, Cao, Yumeng, Abeling, Kira, Akimov, Andrei, Capua, Marcella, Cardarelli, Roberto, Cardillo, Fabio, Carducci, Giovandomenico, Carli, Tancredi, Carlino, Giampaolo, Carlson, B. T., Carlson, Evan Michael, Carminati, Leonardo, Carney, Rebecca, Al Khoury, Konie, Caron, Sascha, Carquin Lopez, Edson, Carra, Sonia, Carratta, Giuseppe, Carter, J. W. S., Carter, Thomas Michael, Casado Lechuga, Pilar, Chan, Terry Ws, Chiu, Justin, Chow, Edwin, Alberghi, Gian Luigi, Crosetti, Nanni, Cunningham, Liam, Darbo, Nanni, Fehr, Armin, Fischer, Julian, Gkougkousis, Vagelis, Hsu, Pai-hsien, Kaya, Colette, Khubua, Djemal, Kock, Daniela, Albert, Justin, Kowalewski, Bob, Koultchitski, Yuri, Le Compte, Tom, Liss, Anthony Michael, Macdonell, Danika Marina, Malecki, Pawel, Casha, Albert Francis, Castiglia, Emma Grace, Castillo, Florencia Luciana, Castillo Garcia, Lucia, Verzini, M. J. Alconada, Castillo Gimenez, Victoria, Castro, Nuno, Catinaccio, Andrea, Catmore, James, Cattai, Ariella, Cavaliere, Viviana, Cavasinni, Vincenzo, Celebi, Emre, Celli, Federico, Cerny, Karel, Alderweireldt, Sara, Santiago Cerqueira, Augusto, Cerri, Alex, Cerrito, Lucio, Cerutti, Fabio, Cervelli, Alberto, Cetin, Serkant, Chadi, Zakaria, Chakraborty, Dhiman, Chan, Jay, Chan, W. S., Aleksa, Martin, Chan, Wai Yuen, Chapman, John Derek, Chargeishvili, Bakar, Charlton, Dave, Charman, Thomas Paul, Chatterjee, Meghranjana, Chau, Chav Chhiv, Chekanov, Sergei, Chekulaev, Sergey, Chelkov, G. A., Aleksandrov, I. N., Chen, Boping, Chen, Cheng, Chen, Chunhui, Chen, Huirun, Chen, Hucheng, Chen, Jing, Chen, Jue, Chen, Jiayi, Chen, Shion, Chen, Shenjian, Alexa, Calin, Chen, Xin, Chen, Ye, Chen, Yu-heng, Cheng, Hok Chuen, Cheng, Huajie, Cheplakov, Alexander, Cheremushkina, Evgeniya, Cherkaoui El Moursli, Rajaa, Cheu, Elliott, Cheung, Kingman, Alexopoulos, Theodoros, Chevalerias, Thibault, Chevalier, Laurent, Chiarella, Vitaliano, Chiarelli, Giorgio, Chiodini, Gabriele, Chisholm, Andrew Stephen, Chitan, Adrian, Chiu, I-huan, Chiu, Y. H., Chizhov, Mihail, Abhayasinghe, Deshan Kavishka, Alfonsi, Alice, Choi, Kyungeon, Chomont, Arthur, Chou, Yuan-tang, Chow, Y. S., Christopher, Lawrence Davou, Chu, Ming Chung, Chu, Xiaotong, Chudoba, Jiri, Chwastowski, Janusz, Cieri, Davide, Alfonsi, Fabrizio, Ciesla, Krzysztof, Cindro, Vladimir, Cioara, Irina Antonela, Ciocio, Alessandra, Cirotto, Francesco, Citron, Z. H., Citterio, Mauro, Ciubotaru, Dan Andrei, Ciungu, Bianca Monica, Clark, Allan, Alhroob, Muhammad, Clark, Philip, Clawson, Savannah, Clement, Christophe, Clissa, Luca, Coadou, Yann, Cobal, Marina, Coccaro, Andrea, Cochran Jr, James Herbert, Coelho Lopes De Sa, Rafael, Cohen, Hadar, Ali, Babar, Coimbra, A. E. C., Cole, Brian, Collot, Johann, Conde Muino, Patricia, Connell, Simon, Connelly, Ian Allan, Conventi, Francesco, Cooper-Sarkar, A. M., Cormier, Felix, Corpe, Louie Dartmoor, Ali, Shahzad, Corradi, Massimo, Corrigan, Eric Edward, Corriveau, Francois, Costa Mezquita, Maria Jose, Costanza, Francesco, Costanzo, Davide, Cowan, Glen, Cowley, James William, Crane, Jonathan, Cranmer, Kyle Stuart, Aliev, Malik, Creager, Rachael Ann, Crepe-renaudin, Sabine, Crescioli, Francesco, Cristinziani, Markus, Cristoforetti, Marco, Croft, Vincent Alexander, Crosetti, G., Cueto Gomez, Ana Rosario, Cuhadar Donszelmann, Tulay, Cui, Han, Alimonti, Gianluca, Cukierman, Aviv Ruben, Cunningham, W. R., Czekierda, Sabina Anna, Czodrowski, Patrick Karl, Czurylo, Marta, Da Cunha Sargedas De Sousa, M. J., Da Fonseca Pinto, Joao Victor, Da Via, Cinzia, Dabrowski, Wladyslaw, Dachs, Florian, Allaire, Corentin, Dado, Tomas, Dahbi, Salah-eddine, Dai, Tiesheng, Dallapiccola, Carlo, Dam, Mogens, D'amen, Gabriele, D'amico, Valerio, Damp, Johannes Frederic, Dandoy, Jeff, Daneri, Maria Florencia, Allbrooke, Benedict, Danninger, Matthias, Dao, Valerio, Darbo, G., Dartsi, Olympia, Dattagupta, Aparajita, D'auria, Saverio, David, Claire, Davidek, Tomas, Davis, Douglas Raymond, Dawson, Ian, Allport, Philip Patrick, De, Kaushik, De Asmundis, Riccardo, De Beurs, Marcus, De Castro, Stefano, De Groot, Nicolo, De Jong, Paul, De La Torre Perez, Hector, De Maria, Antonio, De Pedis, Daniele, De Salvo, Alessandro, Abidi, Haider, Aloisio, Alberto, De Sanctis, Umberto, De Santis, Maurizio, De Santo, Antonella, De Vivie De Regie, Jean-baptiste, Dedovich, Dmitri, Deiana, Allison Mccarn, Del Peso, Jose, Delabat Diaz, Yasiel, Delgove, David, Deliot, Frederic, Alonso, Francisco, Delitzsch, Chris Malena, Della Pietra, Massimo, Della Volpe, Domenico, Dell'acqua, Andrea, Dell'asta, Lidia, Delmastro, Marco, Delporte, Charles Eliaz, Delsart, Pierre Antoine, Demers Konezny, Sarah Marie, Demichev, Mikhail, Alpigiani, Cristiano, Demontigny, Gabriel, Denisov, Serguei, D'eramo, Louis, Derendarz, Dominik Karol, Derkaoui, Jamal, Derue, Frederic, Dervan, Paul, Desch, Klaus, Dette, Karola, Deutsch, Christopher, Alunno Camelia, Elio, Deviveiros, Pier-olivier, Di Bello, Francesco Armando, Di Ciaccio, Anna, Di Ciaccio, Lucia, Di Donato, Camilla, Di Girolamo, Alessandro, Di Gregorio, Giulia, Di Luca, Andrea, Di Micco, Biagio, Di Nardo, Roberto, Alvarez Estevez, Manuel, Di Sipio, Riccardo, Diaconu, Cristinel, De Almeida Dias, Flavia, Vale, T. Dias Do, Diaz Gutierrez, Marco Aurelio, Diaz Capriles, Federico Guillermo, Dickinson, Jennet Elizabeth, Didenko, Mariia, Diehl, Edward, Dietrich, Janet, Alviggi, Mariagrazia, Diez Cornell, Sergio, Diez Pardos, Carmen, Dimitrievska, Aleksandra, Ding, Wei, Dingfelder, Jochen Christian, Dittmeier, Sebastian, Dittus, Fido, Djama, Fares, Djobava, Tamar, Djuvsland, Julia Isabell, Do Amaral Coutinho, Yara, Barros Do Vale, Aline, Dobre, Monica, Dodsworth, David Michael, Doglioni, Caterina, Dolejsi, Jiri, Dolezal, Zdenek, Donadelli, Marisilvia, Dong, Binbin, Donini, Julien Noce, D'onofrio, Adelina, Ambler, Alessandro, D'onofrio, Monica, Dopke, Jens, Doria, Alessandra, Dova, Maria Teresa, Doyle, Tony, Drechsler, Eric, Dreyer, Etienne, Dreyer, Timo, Drobac, Alec Swenson, Du, Dongshuo, Ambroz, Luca, Du Pree, Tristan Arnoldus, Duan, Yanyun, Dubinin, Filipp, Dubovsky, Michal, Dubreuil, Arnaud, Duchovni, Ehud, Duckeck, Guenter, Ducu, Otilia Anamaria, Duda, Dominik, Dudarev, Alexey, Amelung, Christoph, Dudder, Andreas Christian, D'uffizi, Matteo, Duflot, Laurent, Duehrssen-debling, Michael, Dulsen, Carsten, Dumancic, Mirta, Dumitriu, Ana Elena, Dunford, Monica, Dungs, Sascha, Duperrin, Arnaud, AbouZeid, O. S., Amidei, Dante, Yildiz, H. Duran, Dueren, Michael Johannes, Durglishvili, Archil, Dutta, Baishali, Duvnjak, Damir, Dyckes, G. I., Dyndal, Mateusz, Dysch, Samuel Dezso, Dziedzic, Bartosz Sebastian, Eggleston, Michael Glenn, Amor Dos Santos, Susana Patricia, Eifert, Till, Eigen, Gerald, Einsweiler, Kevin Frank, Ekelof, Tord Johan Carl, El Jarrari, Hassnae, El Moussaouy, Ali, Ellajosyula, Venugopal, Ellert, Mattias, Ellinghaus, Frank, Elliot, Alison, Amoroso, Simone, Ellis, Nick, Elmsheuser, Johannes, Elsing, Markus, Emeliyanov, Dmitry, Emerman, Alex, Enari, Yuji, Erdmann, Johannes, Ereditato, Antonio, Erland, Paula Agnieszka, Errenst, Martin, Amrouche, Cherifa Sabrina, Escalier, Marc, Escobar Ibanez, Carlos, Estrada Pastor, Oscar, Etzion, Erez, Gaspar De Andrade Evans, Guiomar, Evans, Hal, Evans, Meirin Oan, Ezhilov, Aleksei, Fabbri, Federica, Fabbri, Laura, Anastopoulos, Christos, Fabiani, Veronica, Facini, Gabriel, Fakhrutdinov, Rinat, Falciano, Speranza, Falke, Peter Johannes, Falke, Saskia, Faltova, Jana, Fang, Yi, Fang, Yaquan, Fanourakis, Georgios, Andari, Nansi, Fanti, Marcello, Faraj, Mohammed, Farbin, Amir, Farilla, Ada, Farina, Edoardo Maria, Farooque, Trisha, Farrington, Sinead, Farthouat, Philippe, Fassi, Farida, Fassouliotis, Dimitris, Andeen, Timothy Robert, Faucci Giannelli, Michele, Fawcett, William James, Fayard, Louis, Fedin, Oleg, Feickert, Matthew Carl, Feligioni, Lorenzo, Fell, Alix, Feng, Cunfeng, Feng, Minyu, Fenton, Michael James, Anders, John Kenneth, Fenyuk, Alexandre, Ferguson, Sarah Whitney, Ferrando, James Edward, Ferrari, Arnaud, Ferrari, Pamela, Ferrari, Roberto, Ferrere, Didier, Ferretti, Claudio, Fiedler, Frank, Filipcic, Andrej, Andrean, Stefio Yosse, Filthaut, Frank, Finelli, Kevin Daniel, Castro Nunes Fiolhais, Miguel, Fiorini, Luca, Fischer, Florian, Fisher, Wade Cameron, Fitschen, Tobias, Fleck, Ivor, Fleischmann, Philipp, Flick, Tobias, Andreazza, Attilio, Flierl, Bernhard Matthias, Flores, Lucas Macrorie, Flores Castillo, Luis Roberto, Follega, Francesco Maria, Fomin, Nikolai, Foo, Joel Hengwei, Forcolin, Giulio Tiziano, Forland, Blake Christopher, Formica, Andrea, Forster, Fabian Alexander, Abouzeid, Hass, Andrei, Victor, Forti, Alessandra, Fortin, Etienne Marie, Foti, Maria Giovanna, Fournier, Daniel, Fox, Harald, Francavilla, Paolo, Francescato, Simone, Franchini, Matteo, Franchino, Silvia, Francis, David, Anelli, Christopher Ryan, Franco, Luca, Franconi, Laura, Franklin, Melissa, Frattari, Guglielmo, Freeman, Patrick Moriishi, Freund, Benjamin, Spolidoro Freund, Werner, Freundlich, Elena Murielle, Frizzell, Dylan Cooper, Froidevaux, Daniel, Angelidakis, Stylianos, Frost, James, Fujimoto, Minori, Fullana Torregrosa, Esteban, Fusayasu, Takahiro, Fuster Verdu, Juan, Gabrielli, Alessandro, Gabrielli, Andrea, Gadow, Paul Philipp, Gagliardi, Guido, Gagnon, Louis-guillaume, Angerami, Aaron, Gallardo, Gabriel, Gallas, Elizabeth, Gallop, Bruce Joseph, Gamboa Goni, Rodrigo, Gan, Kock Kiam, Ganguly, Sanmay, Gao, Jun, Gao, Yanyan, Gao, Yongsheng, Garay Walls, Francisca, Anisenkov, Alexey, Garcia, Carmen, Garcia Navarro, Jose Enrique, Pascual, J. A. García, Garcia-sciveres, Maurice, Gardner Jr, Robert William, Gargiulo, Simona, Garner, Christopher Andrew, Garonne, Vincent, Gasiorowski, Sean Joseph, Do Nascimento Gaspar, Philipp, Annovi, Alberto, Gaudio, Gabriella, Gauzzi, Paolo, Gavrilenko, Igor, Gavriliuk, Aleksandr, Gay, Colin Warren, Gaycken, Goetz, Gazis, Evangelos, Geanta, Andrei Alexandru, Gee, Carolyn, Gee, C. N. P., Antel, Claire, Geisen, Jannik, Geisen, Marc, Gemme, Claudia, Genest, Marie-helene, Geng, Cong, Gentile, Simonetta, George, Simon, Geralis, Theodoros, Gerlach, Lino Oscar, Gessinger-befurt, Paul, Anthony, Matthew Thomas, Gessner, Gregor, Ghasemi Bostanabad, Meisam, Ghneimat, Mazuza, Ghosh, Aishik, Ghosh, Anindya, Giacobbe, Benedetto, Giagu, Stefano, Giangiacomi, Nico, Giannetti, Paola, Giannini, Antonio, Antipov, Egor, Giannini, Giulia, Gibson, Stephen, Gignac, Matthew, Gil, Damian Tomasz, Gilbert, Benjamin Jacob, Gillberg, Dag, Gilles, Geoffrey, Gillwald, N. E. K., Gingrich, Doug, Giordani, Mapo, Antonelli, Mario, Giraud, Pierre-francois, Giugliarelli, Gilberto, Giugni, Danilo, Giuli, Francesco, Gkaitatzis, Stamatios, Gkialas, Ioannis, Gkougkousis, E. L., Gkountoumis, Panagiotis, Gladilin, Leonid, Glasman, Claudia, Abraham, Nicola Louise, Antrim, Daniel Joseph, Gledhill, Galen Rhodes, Gnesi, Ivan, Goblirsch-kolb, Maximilian Emanuel, Godin, Dominique, Goldfarb, Steven, Golling, Tobias, Golubkov, Dmitry, Da Silva Gomes, Agostinho, Goncalves Gama, Rafael, Morais Silva Goncalo, Ricardo Jose, Anulli, Fabio, Gonella, Giulia, Gonella, Laura, Gongadze, Alexi, Gonnella, Francesco, Gonski, Julia Lynne, Gonzalez De La Hoz, Santiago, Gonzalez Fernandez, Sergio, Gonzalez Lopez, Ricardo, Gonzalez Renteria, Cesar, Gonzalez Suarez, Rebeca, Aoki, Masato, Gonzalez Sevilla, Sergio, Gonzalvo Rodriguez, Galo Rafael, Goossens, Luc, Gorasia, Nandish Arjan, Gorbounov, Petr, Gordon, Howard, Gorini, Benedetto, Gorini, Edoardo, Gorisek, Andrej, Goshaw, A. T., Aparisi Pozo, Javier Alberto, Gostkin, Mikhail, Gottardo, Carlo Alberto, Gouighri, Mohamed, Goussiou, Anna, Govender, Nicolin, Goy, Corinne, Grabowska-bold, Iwona, Gramstad, Eirik, Grancagnolo, Sergio, Grandi, Mario, Aparo, Marco, Grachev, Vadim, Gravila, Paul, Gravili, Francesco Giuseppe, Gray, Chloe, Gray, Heather, Grefe, Christian, Gregor, Ingrid, Grenier, Philippe, Grevtsov, Kirill, Grieco, Chiara, Aperio Bella, Ludovica, Grieser, Nathan Allen, Grillo, Alex, Grimm, Kathryn, Grinstein, Sebastian, Grivaz, Jean-francois, Groh, Sabrina, Gross, Eilam, Grosse-knetter, Joern, Grout, Zara Jane, Grud, Christopher Ryan, Aranzabal Barrio, Nordin, Grummer, Aidan, Grundy, James Cameron, Guan, Liang, Guan, Wen, Gubbels, Chris, Guenther, Jaroslav, Rojas, J. G. R. Guerrero, Guescini, Francesco, Guest, Dan, Gugel, Ralf, Araujo Ferraz, Victor, Guida, Alessandro, Guillemin, Thibault, Guindon, Stefan, Guo, Jun, Guo, Ziyu, Gupta, Ruchi, Gurbuz, Saime, Gustavino, Giuliano, Guth, Manuel, Gutierrez, Phillip, Pereira, R. Araujo, Gutierrez Zagazeta, Luis Felipe, Gutschow, Christian, Guyot, Claude, Gwenlan, Claire, Gwilliam, Carl, Haaland, Even Simonsen, Haas, Andrew, Haber, Carl, Hadavand, Haleh, Hadef, Asma, Arcangeletti, Chiara, Haleem, Mahsana, Haley, Joseph, Hall, Jack Joseph, Halladjian, Garabed, Hallewell, Gregory, Hamano, Kenji, Hamdaoui, Hassane, Hamer, Matthias, Hamity, Guillermo Nicolas, Han, Kunlin, ATLAS (IHEF, IoP, FNWI), İstinye Üniversitesi, Adiguzel, A, UAM. Departamento de Física Teórica, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Brandt, Oleg [0000-0001-5219-1417], Burr, Jon [0000-0001-6726-6362], Chapman, John [0000-0002-2926-8962], Fawcett, William [0000-0003-2596-8264], Hommels, Leonard [0000-0003-0684-600X], Lester, Christopher [0000-0001-5770-4883], Pacey, Holly [0000-0002-2325-6792], Parker, Andy [0000-0001-9798-8411], Potter, Christina [0000-0002-9815-5208], Robinson, David [0000-0001-6169-4868], Williams, Sarah [0000-0001-6174-401X], Yallup, David [0000-0003-4716-5817], Apollo - University of Cambridge Repository, Aad, G, Bachas, K, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, ATLAS Collaboration, And, Aad, G., Abbott, B., Abbott, D. C., Abed Abud, A., Abeling, K., Abhayasinghe, D. K., Abidi, S. H., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Achkar, B., Adam, L., Adam Bourdarios, C., Adamczyk, L., Adamek, L., Adelman, J., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Aggarwal, A., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ai, X., Aielli, G., Akatsuka, S., Akbiyik, M., Åkesson, T. P. A., Akilli, E., Akimov, A. V., Al Khoury, K., Alberghi, G. L., Albert, J., Alconada Verzini, M. J., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alfonsi, A., Alfonsi, F., Alhroob, M., Ali, B., Ali, S., Aliev, M., Alimonti, G., Allaire, C., Allbrooke, B. M. M., Allport, P. P., Aloisio, A., Alonso, F., Alpigiani, C., Alunno Camelia, E., Alvarez Estevez, M., Alviggi, M. G., Amaral Coutinho, Y., Ambler, A., Ambroz, L., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amoroso, S., Amrouche, C. S., Anastopoulos, C., Andari, N., Andeen, T., Anders, J. K., Andrean, S. Y., Andreazza, A., Andrei, V., Anelli, C. R., Angelidakis, S., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antipov, E., Antonelli, M., Antrim, D. J. A., Anulli, F., Aoki, M., Aparisi Pozo, J. A., Aparo, M. A., Aperio Bella, L., Aranzabal, N., Araujo Ferraz, V., Araujo Pereira, R., Arcangeletti, C., Arce, A. T. H., Arguin, J-F., Argyropoulos, S., Arling, J. -H., Armbruster, A. J., Armstrong, A., Arnaez, O., Arnold, H., Arrubarrena Tame, Z. P., Artoni, G., Asada, H., Asai, K., Asai, S., Asawatavonvanich, T., Asbah, N. A., Asimakopoulou, E. M., Asquith, L., Assahsah, J., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Atmani, H., Atmasiddha, P. A., Augsten, K., Austrup, V. A., Avolio, G., Ayoub, M. K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Backman, F., Bagnaia, P., Bahrasemani, H., Bailey, A. J., Bailey, V. R., Baines, J. T., Bakalis, C., Baker, O. K., Bakker, P. J., Bakos, E., Bakshi Gupta, D., Balaji, S., Balasubramanian, R., Baldin, E. M., Balek, P., Balli, F., Balunas, W. K., Balz, J., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Barak, L., Barbe, W. M., Barberio, E. L., Barberis, D., Barbero, M., Barbour, G., Barillari, T., Barisits, M-S., Barkeloo, J., Barklow, T., Barnett, B. M., Barnett, R. M., Barnovska-Blenessy, Z., Baroncelli, A., Barone, G., Barr, A. J., Barranco Navarro, L., Barreiro, F., Barreiro Guimarães da Costa, J., Barron, U., Barsov, S., Bartels, F., Bartoldus, R., Bartolini, G., Barton, A. E., Bartos, P., Basalaev, A., Basan, A., Bassalat, A., Basso, M. J., Basson, C. R., Bates, R. L., Batlamous, S., Batley, J. R., Batool, B., Battaglia, M., Bauce, M., Bauer, F., Bauer, P., Bawa, H. S., Bayirli, A., Beacham, J. B., Beau, T., Beauchemin, P. H., Becherer, F., Bechtle, P., Beck, H. P., Becker, K., Becot, C., Beddall, A. J., Bednyakov, V. A., Bee, C. P., Beermann, T. A., Begalli, M., Begel, M., Behera, A., Behr, J. K., Beisiegel, F., Belfkir, M., Bella, G., Bellagamba, L., Bellerive, A., Bellos, P., Beloborodov, K., Belotskiy, K., Belyaev, N. L., Benchekroun, D., Benekos, N., Benhammou, Y., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Bergeaas Kuutmann, E., Berger, N., Bergmann, B., Bergsten, L. J., Beringer, J., Berlendis, S., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Berthold, A., Bertram, I. A., Bessidskaia Bylund, O., Bethke, S., Betti, A., Bevan, A. J., Bhatta, S., Bhattacharya, D. S., Bhattarai, P., Bhopatkar, V. S., Bi, R., Bianchi, R. M., Biebel, O., Biedermann, D., Bielski, R., Bierwagen, K., Biesuz, N. V., Biglietti, M., Billoud, T. R. V., Bindi, M., Bingul, A., Bini, C., Biondi, S., Birch-sykes, C. J., Birman, M., Bisanz, T., Biswal, J. P., Biswas, D., Bitadze, A., Bittrich, C., Bjørke, K., Blazek, T., Bloch, I., Blocker, C., Blue, A., Blumenschein, U., Blumenthal, J., Bobbink, G. J., Bobrovnikov, V. S., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Bomben, M., Bona, M., Bonilla, J. S., Boonekamp, M., Booth, C. D., Borbély, A. G., Borecka-Bielska, H. M., Borgna, L. S., Borisov, A., Borissov, G., Bortoletto, D., Boscherini, D., Bosman, M., Bossio Sola, J. D., Bouaouda, K., Boudreau, J., Bouhova-Thacker, E. V., Boumediene, D., Bouquet, R., Boveia, A., Boyd, J., Boye, D., Boyko, I. R., Bozson, A. J., Bracinik, J., Brahimi, N., Brandt, G., Brandt, O., Braren, F., Brau, B., Brau, J. E., Breaden Madden, W. D., Brendlinger, K., Brener, R., Brenner, L., Brenner, R., Bressler, S., Brickwedde, B., Briglin, D. L., Britton, D., Britzger, D., Brock, I., Brock, R., Brooijmans, G., Brooks, W. K., Brost, E., Bruckman de Renstrom, P. A., Brüers, B., Bruncko, D., Bruni, A., Bruni, G., Bruschi, M., Bruscino, N., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Budagov, I. A., Bugge, M. K., Bulekov, O., Bullard, B. A., Burch, T. J., Burdin, S., Burgard, C. D., Burger, A. M., Burghgrave, B., Burr, J. T. P., Burton, C. D., Burzynski, J. C., Büscher, V., Buschmann, E., Bussey, P. J., Butler, J. M., Buttar, C. M., Butterworth, J. M., Buttinger, W., Buxo Vazquez, C. J., Buzykaev, A. R., Cabras, G., Cabrera Urbán, S., Caforio, D., Cai, H., Cairo, V. M. M., Cakir, O., Calace, N., Calafiura, P., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Caltabiano, A., Calvente Lopez, S., Calvet, D., Calvet, S., Calvet, T. P., Calvetti, M., Camacho Toro, R., Camarda, S., Camarero Munoz, D., Camarri, P., Camerlingo, M. T., Cameron, D., Camincher, C., Campanelli, M., Camplani, A., Canale, V., Canesse, A., Cano Bret, M., Cantero, J., Cao, Y., Capua, M., Cardarelli, R., Cardillo, F., Carducci, G., Carli, T., Carlino, G., Carlson, B. T., Carlson, E. M., Carminati, L., Carney, R. M. D., Caron, S., Carquin, E., Carrá, S., Carratta, G., Carter, J. W. S., Carter, T. M., Casado, M. P., Casha, A. F., Castiglia, E. G., Castillo, F. L., Castillo Garcia, L., Castillo Gimenez, V., Castro, N. F., Catinaccio, A., Catmore, J. R., Cattai, A., Cavaliere, V., Cavasinni, V., Celebi, E., Celli, F., Cerny, K., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cervelli, A., Cetin, S. A., Chadi, Z., Chakraborty, D., Chan, J., Chan, W. S., Chan, W. Y., Chapman, J. D., Chargeishvili, B., Charlton, D. G., Charman, T. P., Chatterjee, M., Chau, C. C., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chen, B., Chen, C., Chen, C. H., Chen, H., Chen, J., Chen, S., Chen, S. J., Chen, X., Chen, Y., Chen, Y-H., Cheng, H. C., Cheng, H. J., Cheplakov, A., Cheremushkina, E., Cherkaoui El Moursli, R., Cheu, E., Cheung, K., Chevalérias, T. J. A., Chevalier, L., Chiarella, V., Chiarelli, G., Chiodini, G., Chisholm, A. S., Chitan, A., Chiu, I., Chiu, Y. H., Chizhov, M. V., Choi, K., Chomont, A. R., Chou, Y., Chow, Y. S., Christopher, L. D., Chu, M. C., Chu, X., Chudoba, J., Chwastowski, J. J., Cieri, D., Ciesla, K. M., Cindro, V., Cioară, I. A., Ciocio, A., Cirotto, F., Citron, Z. H., Citterio, M., Ciubotaru, D. A., Ciungu, B. M., Clark, A., Clark, P. J., Clawson, S. E., Clement, C., Clissa, L., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., Coelho Lopes De Sa, R., Cohen, H., Coimbra, A. E. C., Cole, B., Collot, J., Conde Muiño, P., Connell, S. H., Connelly, I. A., Conventi, F., Cooper-Sarkar, A. M., Cormier, F., Corpe, L. D., Corradi, M., Corrigan, E. E., Corriveau, F., Costa, M. J., Costanza, F., Costanzo, D., Cowan, G., Cowley, J. W., Crane, J., Cranmer, K., Creager, R. A., Crépé-Renaudin, S., Crescioli, F., Cristinziani, M., Cristoforetti, M., Croft, V., Crosetti, G., Cueto, A., Cuhadar Donszelmann, T., Cui, H., Cukierman, A. R., Cunningham, W. R., Czekierda, S., Czodrowski, P., Czurylo, M. M., Da Cunha Sargedas De Sousa, M. J., Da Fonseca Pinto, J. V., Da Via, C., Dabrowski, W., Dachs, F., Dado, T., Dahbi, S., Dai, T., Dallapiccola, C., Dam, M., D'Amen, G., D'Amico, V., Damp, J., Dandoy, J. R., Daneri, M. F., Danninger, M., Dao, V., Darbo, G., Dartsi, O., Dattagupta, A., D'Auria, S., David, C., Davidek, T., Davis, D. R., Dawson, I., De, K., De Asmundis, R., De Beurs, M., De Castro, S., De Groot, N., de Jong, P., De la Torre, H., De Maria, A., De Pedis, D., De Salvo, A., De Sanctis, U., De Santis, M., De Santo, A., De Vivie De Regie, J. B., Dedovich, D. V., Deiana, A. M., Del Peso, J., Delabat Diaz, Y., Delgove, D., Deliot, F., Delitzsch, C. M., Della Pietra, M., Della Volpe, D., Dell'Acqua, A., Dell'Asta, L., Delmastro, M., Delporte, C., Delsart, P. A., Demers, S., Demichev, M., Demontigny, G., Denisov, S. P., D'Eramo, L., Derendarz, D., Derkaoui, J. E., Derue, F., Dervan, P., Desch, K., Dette, K., Deutsch, C., Deviveiros, P. O., Di Bello, F. A., Di Ciaccio, A., Di Ciaccio, L., Di Donato, C., Di Girolamo, A., Di Gregorio, G., Di Luca, A., Di Micco, B., Di Nardo, R., Di Sipio, R., Diaconu, C., Dias, F. A., Dias Do Vale, T., Diaz, M. A., Diaz Capriles, F. G., Dickinson, J., Didenko, M., Diehl, E. B., Dietrich, J., Díez Cornell, S., Diez Pardos, C., Dimitrievska, A., Ding, W., Dingfelder, J., Dittmeier, S. J., Dittus, F., Djama, F., Djobava, T., Djuvsland, J. I., Do Vale, M. A. B., Dobre, M., Dodsworth, D., Doglioni, C., Dolejsi, J., Dolezal, Z., Donadelli, M., Dong, B., Donini, J., D'Onofrio, A., D'Onofrio, M., Dopke, J., Doria, A., Dova, M. T., Doyle, A. T., Drechsler, E., Dreyer, E., Dreyer, T., Drobac, A. S., Du, D., du Pree, T. A., Duan, Y., Dubinin, F., Dubovsky, M., Dubreuil, A., Duchovni, E., Duckeck, G., Ducu, O. A., Duda, D., Dudarev, A., Dudder, A. C., D'Uffizi, M., Duflot, L., Dührssen, M., Dülsen, C., Dumancic, M., Dumitriu, A. E., Dunford, M., Dungs, S., Duperrin, A., Duran Yildiz, H., Düren, M., Durglishvili, A., Dutta, B., Duvnjak, D., Dyckes, G. I., Dyndal, M., Dysch, S., Dziedzic, B. S., Eggleston, M. G., Eifert, T., Eigen, G., Einsweiler, K., Ekelof, T., El Jarrari, H., El Moussaouy, A., Ellajosyula, V., Ellert, M., Ellinghaus, F., Elliot, A. A., Ellis, N., Elmsheuser, J., Elsing, M., Emeliyanov, D., Emerman, A., Enari, Y., Erdmann, J., Ereditato, A., Erland, P. A., Errenst, M., Escalier, M., Escobar, C., Estrada Pastor, O., Etzion, E., Evans, G., Evans, H., Evans, M. O., Ezhilov, A., Fabbri, F., Fabbri, L., Fabiani, V., Facini, G., Fakhrutdinov, R. M., Falciano, S., Falke, P. 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J., Gillberg, D., Gilles, G., Gillwald, N. E. K., Gingrich, D. M., Giordani, M. P., Giraud, P. F., Giugliarelli, G., Giugni, D., Giuli, F., Gkaitatzis, S., Gkialas, I., Gkougkousis, E. L., Gkountoumis, P., Gladilin, L. K., Glasman, C., Gledhill, G. R., Gnesi, I., Goblirsch-Kolb, M., Godin, D., Goldfarb, S., Golling, T., Golubkov, D., Gomes, A., Goncalves Gama, R., Gonçalo, R., Gonella, G., Gonella, L., Gongadze, A., Gonnella, F., Gonski, J. L., González de la Hoz, S., Gonzalez Fernandez, S., Gonzalez Lopez, R., Gonzalez Renteria, C., Gonzalez Suarez, R., Gonzalez-Sevilla, S., Gonzalvo Rodriguez, G. R., Goossens, L., Gorasia, N. A., Gorbounov, P. A., Gordon, H. A., Gorini, B., Gorini, E., Gorišek, A., Goshaw, A. T., Gostkin, M. I., Gottardo, C. A., Gouighri, M., Goussiou, A. G., Govender, N., Goy, C., Grabowska-Bold, I., Gramstad, E., Grancagnolo, S., Grandi, M., Gratchev, V., Gravila, P. M., Gravili, F. G., Gray, C., Gray, H. M., Grefe, C., Gregor, I. M., Grenier, P., Grevtsov, K., Grieco, C., Grieser, N. A., Grillo, A. A., Grimm, K., Grinstein, S., Grivaz, J. -F., Groh, S., Gross, E., Grosse-Knetter, J., Grout, Z. J., Grud, C., Grummer, A., Grundy, J. C., Guan, L., Guan, W., Gubbels, C., Guenther, J., Guerrero Rojas, J. G. R., Guescini, F., Guest, D., Gugel, R., Guida, A., Guillemin, T., Guindon, S., Guo, J., Guo, Z., Gupta, R., Gurbuz, S., Gustavino, G., Guth, M., Gutierrez, P., Gutierrez Zagazeta, L. F., Gutschow, C., Guyot, C., Gwenlan, C., Gwilliam, C. B., Haaland, E. S., Haas, A., Haber, C., Hadavand, H. K., Hadef, A., Haleem, M., Haley, J., Hall, J. J., Halladjian, G., Hallewell, G. D., Hamano, K., Hamdaoui, H., Hamer, M., Hamity, G. N., Han, K., Han, L., Han, S., Han, Y. F., Hanagaki, K., Hance, M., Hank, M. D., Hankache, R., Hansen, E., Hansen, J. B., Hansen, J. D., Hansen, M. C., Hansen, P. H., Hanson, E. C., Hara, K., Harenberg, T., Harkusha, S., Harrison, P. F., Hartman, N. M., Hartmann, N. 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G., Zou, R., Zou, W., Zwalinski, L., and Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2843
Subjects: Physics and Astronomy (miscellaneous), Большой адронный коллайдер, Physics::Instrumentation and Detectors, 13000 GeV-cms, trigger [muon], bottom: particle identification, Particle tracking, proton proton collisions, lhc, Tracking (particle physics), High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), Subatomic Physics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], scattering [p p], Boson, multiplicity, протон-протонные столкновения, trigger [electron], Partons, Physics, Settore FIS/01, Large Hadron Collider, Detector, ATLAS experiment, Higgs Bosons, ATLAS, bottom [jet], tau: trigger, medicine.anatomical_structure, CERN LHC Coll, trigger [tau], particle identification [bottom], colliding beams [p p], jet: bottom, Particle Physics - Experiment, jet: trigger, signature, Particle physics, p p: scattering, Regular Article - Experimental Physics, 530 Physics, electron: trigger, FOS: Physical sciences, LHC, ATLAS, High Energy Physics, Atlas (anatomy), medicine, ddc:530, High Energy Physics, Engineering (miscellaneous), Muon, Física, performance [trigger], Multiplicity (mathematics), muon: trigger, trigger [jet], crossing, trigger: performance, Experimental High Energy Physics, Physics::Accelerator Physics, High Energy Physics::Experiment, ATLAS, детектор, p p: colliding beams, Energy (signal processing), experimental results
Abstract: The authors thank CERN for the very successful operation of the LHC, as well as the support staff from the institutions without whom ATLAS could not be operated efficiently. The authors also gratefully acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; Minciencias, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRI, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MEiN, Poland; FCT, Portugal; MNE/IFA, Romania; JINR; MES of Russia and NRCKI, Russian Federation; MESTD, Serbia; MSSR, Slovakia; ARRSandMIZS, Slovenia; DSI/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada and CRC, Canada; COST, ERC, ERDF, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSFNSF and GIF, Israel; Norwegian FinancialMechanism 2014-2021, Norway; NCNandNAWA, Poland; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CCIN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NLT1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed elsewhere [67]., The design and performance of the inner detector trigger for the high level trigger of the ATLAS experiment at the Large Hadron Collider during the 2016–2018 data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector recorded 35.6 fb−1, 46.9 fb−1, and 60.6 fb−1 respectively of proton–proton collision data at a centre-of-mass energy of 13TeV. In order to deal with the very high interaction multiplicities per bunch crossing expected with the 13TeV collisions the inner detector trigger was redesigned during the long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of these developments is provided and the performance of the tracking in the trigger for the muon, electron, tau and b-jet signatures is discussed. The high performance of the inner detector trigger with these extreme interactionmultiplicities demonstrates howthe inner detector tracking continues to lie at the heart of the trigger performance and is essential in enabling the ATLAS physics programme., ANPCyT, YerPhI, Armenia, Australian Research Council, BMWFW, Austria Austrian Science Fund (FWF), Azerbaijan National Academy of Sciences (ANAS), SSTC, Belarus, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Natural Sciences and Engineering Research Council of Canada (NSERC) NRC, Canada Canada Foundation for Innovation, CERN, ANID, Chile, Chinese Academy of Sciences Ministry of Science and Technology, China National Natural Science Foundation of China (NSFC), Minciencias, Colombia, Ministry of Education, Youth & Sports - Czech Republic Czech Republic Government Czech Republic Government, DNRF, Denmark Danish Natural Science Research Council, Centre National de la Recherche Scientifique (CNRS) CEA-DRF/IRFU, France, SRNSFG, Georgia, Federal Ministry of Education & Research (BMBF), HGF, Germany Max Planck Society, GSRI, Greece, RGC, China Hong Kong SAR, China, Israel Science Foundation Benoziyo Center, Israel, Istituto Nazionale di Fisica Nucleare (INFN), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science, CNRST, Morocco, Netherlands Organization for Scientific Research (NWO) Netherlands Government, RCN, Norway, MEiN, Poland, Portuguese Foundation for Science and Technology European Commission, MNE/IFA, Romania, JINR, Russian Federation, Ministry of Education, Science & Technological Development, Serbia, MSSR, Slovakia, Slovenian Research Agency - Slovenia MIZS, Slovenia, DSI/NRF, South Africa, Spanish Government, SRC, Sweden Wallenberg Foundation, Sweden, SERI, Switzerland Swiss National Science Foundation (SNSF) Canton of Bern, Switzerland Canton of Geneva, Switzerland, Ministry of Science and Technology, Taiwan, Ministry of Energy & Natural Resources - Turkey, UK Research & Innovation (UKRI), Science & Technology Facilities Council (STFC), United States Department of Energy (DOE), National Science Foundation (NSF), BCKDF, Canada CANARIE, Canada Compute Canada, Canada CRC, Canada, COST, European Union European Research Council (ERC) ERDF, European Union Horizon 2020, European Union Marie Sklodowska-Curie Actions, European Union, French National Research Agency (ANR), German Research Foundation (DFG), Alexander von Humboldt Foundation, Herakleitos programme - EU-ESF Thales Group Aristeia programme - EU-ESF Greek NSRF, Greece, BSF-NSF, Israel German-Israeli Foundation for Scientific Research and Development, Norwegian FinancialMechanism 2014-2021, Norway, NCN, Poland Polish National Agency for Academic Exchange (NAWA), La Caixa Banking Foundation, Spain CERCA Programme Generalitat de Catalunya, Spain PROMETEO Programme Generalitat Valenciana, Spain GenT Programme Generalitat Valenciana, Spain, Goran Gustafssons Stiftelse, Sweden, Royal Society of London, Leverhulme Trust
Published: 2022
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33. Burden of Disease in PWH Harboring a Multidrug-Resistant Virus: Data from the PRESTIGIO Registry

Author: Galli, L., Parisi, M. R., Poli, A., Menozzi, M., Fiscon, M., Garlassi, E., Francisci, D., DI Biagio, A., Sterrantino, G., Fornabaio, C., Degli Antoni, A., Angarano, G., Fusco, F. M., D'Arminio Monforte, A., Corbelli, G. M., Santoro, M. M., Zazzi, M., Castagna, A., Gianotti, N., Maggiolo, F., Calza, L., Foca, E., Cenderello, G., Rusconi, S., Mussini, C., Antinori, A., Gagliardini, R., Bonora, S., Ferrara, M., Santoro, M., Galli, A., Carini, E., Bigoloni, A., Tavio, M., Butini, L., Giacometti, A., Vaccher, E., Martellotta, F., Da Ros, V., Saracino, A., Balena, F., Comi, L., DI Filippo, E., Valenti, D., Suardi, C., Mazzola, B., Viale, P., Del Turco, E. R., Ramirez, M. V., Castelli, F., Celotti, A., Brognoli, F., Bonoldi, G., Menzaghi, B., Abeli, C., Farinazzo, M., Ortu, F., Campus, M., Cacopardo, B., Celesia, M., Pan, A., Bartoloni, A., Rinaldi, F., Giache, S., Pierluigi, B., Vichi, F., Santantonio, T., Ferrara, S., Bruno, S. R., Cassola, G., Marcello, F., Calautti, F., Bassetti, M., Bruzzone, B., Artioli, S., Lazzarin, A., Canetti, D., Galli, M., Formenti, T., Morena, V., Gabrieli, A., Gazzola, L., Merlini, E., Minieri, V., Gori, A., Bandera, A., Pastore, V., Ferroni, V., Puoti, M., Moioli, C., Vassalli, S., Enrica, R., Giulia, N., Beghetto, B., Manzillo, E., Franco, A., Cattelan, A. M., Marinello, S., Cavinato, S., Macario, A., Cascio, A., Mazzola, G., Antoni, A. M. D., Ferrari, C., Laccabue, D., Filice, G., Gulminetti, R., Pagnucco, L., Asti, A., Schiaroli, E., Papalini, C., Italiani, F., DI Pietro, M., Magnani, G., Elisa, G., Barchi, E., Corsini, R., Vergori, A., Cicalini, S., Onnelli, G., Giannetti, A., Cauda, R., Ciccullo, A., La Monica, S., Vullo, V., Dettorre, G., Cavallari, E. N., Andreoni, M., Malagnino, V., Ceccarelli, L., Viviani, F., Sasset, L., Dentone, C., Rossetti, B., Modica, S., Borgo, V., DI Perri, G., Carcieri, C., Malena, M., Padovani, B., Luzzati, R., Centonze, S., Valentinotti, R., Galli L., Parisi M.R., Poli A., Menozzi M., Fiscon M., Garlassi E., Francisci D., DI Biagio A., Sterrantino G., Fornabaio C., Degli Antoni A., Angarano G., Fusco F.M., D'Arminio Monforte A., Corbelli G.M., Santoro M.M., Zazzi M., Castagna A., Gianotti N., Maggiolo F., Calza L., Foca E., Cenderello G., Rusconi S., Mussini C., Antinori A., Gagliardini R., Bonora S., Ferrara M., Santoro M., Galli A., Carini E., Bigoloni A., Tavio M., Butini L., Giacometti A., Vaccher E., Martellotta F., Da Ros V., Saracino A., Balena F., Comi L., DI Filippo E., Valenti D., Suardi C., Mazzola B., Viale P., Del Turco E.R., Ramirez M.V., Castelli F., Celotti A., Brognoli F., Bonoldi G., Menzaghi B., Abeli C., Farinazzo M., Ortu F., Campus M., Cacopardo B., Celesia M., Pan A., Bartoloni A., Rinaldi F., Giache S., Pierluigi B., Vichi F., Santantonio T., Ferrara S., Bruno S.R., Cassola G., Marcello F., Calautti F., Bassetti M., Bruzzone B., Artioli S., Lazzarin A., Canetti D., Galli M., Formenti T., Morena V., Gabrieli A., Gazzola L., Merlini E., Minieri V., Gori A., Bandera A., Pastore V., Ferroni V., Puoti M., Moioli C., Vassalli S., Enrica R., Giulia N., Beghetto B., Manzillo E., Franco A., Cattelan A.M., Marinello S., Cavinato S., MacArio A., Cascio A., Mazzola G., Antoni A.M.D., Ferrari C., Laccabue D., Filice G., Gulminetti R., Pagnucco L., Asti A., Frsdi E., Schiaroli E., Papalini C., Italiani F., DI Pietro M., Magnani G., Elisa G., Barchi E., Corsini R., Vergori A., Cicalini S., Onnelli G., Giannetti A., Cauda R., Ciccullo A., La Monica S., Vullo V., Dettorre G., Cavallari E.N., Andreoni M., Malagnino V., Ceccarelli L., Viviani F., Sasset L., Dentone C., Rossetti B., Modica S., Borgo V., DI Perri G., Carcieri C., Malena M., Padovani B., Luzzati R., Centonze S., Valentinotti R., Galli, L, Parisi, M, Poli, A, Menozzi, M, Fiscon, M, Garlassi, E, Francisci, D, DI Biagio, A, Sterrantino, G, Fornabaio, C, Degli Antoni, A, Angarano, G, Fusco, F, D'Arminio Monforte, A, Corbelli, G, Santoro, M, Zazzi, M, Castagna, A, Gianotti, N, Maggiolo, F, Calza, L, Foca, E, Cenderello, G, Rusconi, S, Mussini, C, Antinori, A, Gagliardini, R, Bonora, S, Ferrara, M, Galli, A, Carini, E, Bigoloni, A, Tavio, M, Butini, L, Giacometti, A, Vaccher, E, Martellotta, F, Da Ros, V, Saracino, A, Balena, F, Comi, L, DI Filippo, E, Valenti, D, Suardi, C, Mazzola, B, Viale, P, Del Turco, E, Ramirez, M, Castelli, F, Celotti, A, Brognoli, F, Bonoldi, G, Menzaghi, B, Abeli, C, Farinazzo, M, Ortu, F, Campus, M, Cacopardo, B, Celesia, M, Pan, A, Bartoloni, A, Rinaldi, F, Giache, S, Pierluigi, B, Vichi, F, Santantonio, T, Ferrara, S, Bruno, S, Cassola, G, Marcello, F, Calautti, F, Bassetti, M, Bruzzone, B, Artioli, S, Lazzarin, A, Canetti, D, Galli, M, Formenti, T, Morena, V, Gabrieli, A, Gazzola, L, Merlini, E, Minieri, V, Gori, A, Bandera, A, Pastore, V, Ferroni, V, Puoti, M, Moioli, C, Vassalli, S, Enrica, R, Giulia, N, Beghetto, B, Manzillo, E, Franco, A, Cattelan, A, Marinello, S, Cavinato, S, Macario, A, Cascio, A, Mazzola, G, Antoni, A, Ferrari, C, Laccabue, D, Filice, G, Gulminetti, R, Pagnucco, L, Asti, A, Schiaroli, E, Papalini, C, Italiani, F, DI Pietro, M, Magnani, G, Elisa, G, Barchi, E, Corsini, R, Vergori, A, Cicalini, S, Onnelli, G, Giannetti, A, Cauda, R, Ciccullo, A, La Monica, S, Vullo, V, Dettorre, G, Cavallari, E, Andreoni, M, Malagnino, V, Ceccarelli, L, Viviani, F, Sasset, L, Dentone, C, Rossetti, B, Modica, S, Borgo, V, DI Perri, G, Carcieri, C, Malena, M, Padovani, B, Luzzati, R, Centonze, S, Valentinotti, R, Galli, Laura, Parisi, Maria Rita, Poli, Andrea, Menozzi, Marianna, Fiscon, Marta, Garlassi, Elisa, Francisci, Daniela, Di Biagio, Antonio, Sterrantino, Gaetana, Fornabaio, Chiara, Degli Antoni, Anna, Angarano, Gioacchino, Fusco, Francesco Maria, D'Arminio Monforte, Antonella, Corbelli, Giulio Maria, Santoro, Maria Mercede, Zazzi, Maurizio, and Castagna, Antonella
Subjects: 0301 basic medicine, medicine.medical_specialty, 4-class drug resistance, AIDS-defining event, cancer, death, non-AIDS-defining event, Population, Major Articles, Settore MED/07, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Internal medicine, medicine, Cumulative incidence, 030212 general & internal medicine, education, Disease burden, education.field_of_study, Proportional hazards model, business.industry, Incidence (epidemiology), Hazard ratio, 030112 virology, AcademicSubjects/MED00290, Infectious Diseases, Oncology, business, Cohort study
Abstract: BackgroundCurrently, no data are available on the burden of morbidity and mortality in people with HIV-1 (PWH) harboring a 4-class drug-resistant (4DR) virus (nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors, integrase strand transfer inhibitors). The study aimed to assess the incidence of clinical events and death in this population.MethodsThis was a cohort study on PWH from the PRESTIGIO Registry with a documented 4DR virus. Burden of disease was defined as the occurrence of any new event including an AIDS-defining event (ADE) or non-AIDS-defining event (NADE) or death from any cause after 4DR evidence (baseline). Cox regression models evaluated factors associated with the risk of new clinical events/death.ResultsAmong 148 PWH followed for a median (interquartile range) of 47 (32–84) months after 4DR evidence, 38 PWH had 62 new events or died from any cause (incidence rate, 9.12/100 person-years of follow-up; 95% CI = 6.85–11.39): 12 deaths (6 AIDS-related and 6 non-AIDS-related), 18 ADEs, 32 NADEs; 20 of the 38 NADEs (45%) of the incident clinical events were malignancies. The 4-year cumulative incidence of death was 6% (95% CI, 3%–13%), and that of ≥1 event or death was 22% (95% CI, 16%–31%). A higher risk of new clinical events/death was more likely in PWH with previous clinical events (adjusted hazard ratio [aHR], 2.67; 95% CI, 1.07–6.67) and marginally associated with lower baseline CD4+/CD8+ ratio (aHR, 0.82; 95% CI, 0.65–1.02).ConclusionsPWH harboring 4DR have a high burden of disease with a worrying incidence of malignancies, strongly advising for close prevention and monitoring interventions as well as access to innovative therapeutic strategies, especially in people with a history of clinical events and low CD4+/CD8+ ratio.
Published: 2020

34. Transcatheter tricuspid valve-in-valve replacement in two patients with Ebstein anomaly: technical considerations

Author: Albrecht Elsässer, Kay Kronberg, Malena Horn, and Fritz Mellert
Subjects: medicine.medical_specialty, Tricuspid valve, business.industry, medicine.medical_treatment, General Medicine, Letter to the Editors, medicine.anatomical_structure, Valve replacement, EBSTEIN ANOMALY, Internal medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract: Graphical abstract Electronic supplementary material The online version of this article (10.1007/s00392-020-01756-0) contains supplementary material, which is available to authorized users.
Published: 2020

35. Merkel cell carcinoma in Latin America: a contribution from an expanded access program for avelumab to address issues from experts’ recommendations

Author: Rodrigo Ramella Munhoz, Malena Tilli, Gabriela Cinat, Jesús Oswaldo Sánchez Castillo, Federico Cayol, Rafael Schmerling, Raquel Gerson, Elluz Oliver Barreto, and Luis Corrales
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Skin Neoplasms, Immunology, Disease, Antibodies, Monoclonal, Humanized, Malignancy, Avelumab, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, Internal medicine, medicine, Humans, Immunology and Allergy, Aged, Aged, 80 and over, Merkel cell carcinoma, business.industry, Middle Aged, Prognosis, medicine.disease, Carcinoma, Merkel Cell, Clinical trial, Latin America, Oncology, Expanded access, Practice Guidelines as Topic, Female, Skin cancer, business, Progressive disease, Follow-Up Studies, 030215 immunology, medicine.drug
Abstract: Merkel cell carcinoma (MCC) is an aggressive malignancy, associated with poor outcomes in patients with metastatic disease (mMCC). Management has been dramatically altered as a result of incorporating immune checkpoint blockade agents. MCC data from Latin America (LATAM) come from case-series or individual records. Regional registries are lacking. A need for better registries to improve current knowledge about MCC is highlighted. Our objectives were to describe a real-world experience with avelumab as a second-line (or first-line in unfit patients) treatment in a subset of LATAM participants enrolled in a global Expanded Access Program (EAP) for patients with mMCC, and to evaluate its contribution to the resolution of the concerns described in a recent regional experts review. We reviewed data of LATAM participants in an avelumab EAP for mMCC treatment (NCT03089658). EAP patient had unresectable or mMCC with progressive disease after one line of chemotherapy, and were ineligible for clinical trials or unfit for chemotherapy. 46 patients (median age: 71.6 years; 60.9% males; median treatment duration: 7.9 months) were included in the LATAM EAP. Physician-assessed objective responses were available for 19 patients. Complete response rate was 15.8% and partial response rate reached 42.1%, summarizing an objective response rate of 57.9%. Stable disease rate was 10.5%, with a disease control response of 68.4%. Avelumab showed robust efficacy and a safety profile consistent with global EAP data. Results are aimed to improve current knowledge about mMCC treatment and access to immunooncologic strategies for treating LATAM patients.
Published: 2020

36. Whole-exome sequencing accuracy in the diagnosis of primary ciliary dyskinesia

Author: Oded Breuer, Alex Gileles-Hillel, David Shoseyov, Israel Amirav, Hagar Mor-Shaked, Reuven Tsabari, Malena Cohen-Cymberknoh, Amjad Horani, Eitan Kerem, Avigdor Hevroni, Joel Reiter, and Shuli Brammli-Greenberg
Subjects: 0301 basic medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Receiver operating characteristic, Primary Ciliary Dyskinesia, business.industry, lcsh:R, lcsh:Medicine, Diagnostic accuracy, Original Articles, medicine.disease, Gastroenterology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030228 respiratory system, Internal medicine, otorhinolaryngologic diseases, Medicine, In patient, business, Exome sequencing, Primary ciliary dyskinesia
Abstract: The diagnosis of primary ciliary dyskinesia (PCD) relies on clinical features and sophisticated studies. The detection of bi-allelic disease-causing variants confirms the diagnosis. However, a standardised genetic panel is not widely available and new disease-causing genes are continuously identified. To assess the accuracy of untargeted whole-exome sequencing (WES) as a diagnostic tool for PCD, patients with symptoms highly suggestive of PCD were consecutively included. Patients underwent measurement of nasal nitric oxide (nNO) levels, ciliary transmission electron microscopy analysis (TEM) and WES. A confirmed PCD diagnosis in symptomatic patients was defined as a recognised ciliary ultrastructural defect on TEM and/or two pathogenic variants in a known PCD-causing gene. Forty-eight patients (46% male) were enrolled, with a median age of 10.0 years (range 1.0–37 years). In 36 patients (75%) a diagnosis of PCD was confirmed, of which 14 (39%) patients had normal TEM. A standalone untargeted WES had a diagnostic yield of 94%, identifying bi-allelic variants in 11 known PCD-causing genes in 34 subjects. A nNO, Untargeted whole-exome sequencing in subjects with clinical symptoms highly suggestive of PCD has an excellent diagnostic accuracy and, as prices drop, may be the genetic test of choice for confirming PCD or establishing an alternative diagnosis https://bit.ly/3j2jMbu
Published: 2020

37. Incidence of CMV Replication and the Role of Letermovir Primary/Secondary Prophylaxis in the Early Phase After Allogeneic Hematopoietic Stem Cell Transplantation – A Single Centre Study

Author: Dimitrios A. Tsakiris, Hans H. Hirsch, Karoline Leuzinger, Nina Khanna, Ursina Studer, Sabine Gerull, Malena Gwerder, Jakob Passweg, Michael Medinger, Dominik Heim, Claudia Lengerke, and Joerg Halter
Subjects: Adult, Male, Cancer Research, medicine.medical_treatment, Congenital cytomegalovirus infection, Cytomegalovirus, Hematopoietic stem cell transplantation, Acetates, Virus Replication, 03 medical and health sciences, Letermovir, 0302 clinical medicine, medicine, Humans, Transplantation, Homologous, Aged, business.industry, Incidence (epidemiology), Hematopoietic Stem Cell Transplantation, virus diseases, General Medicine, Middle Aged, medicine.disease, HLA Mismatch, Transplantation, Haematopoiesis, Oncology, 030220 oncology & carcinogenesis, Cytomegalovirus Infections, Immunology, Quinazolines, Female, Stem cell, business, medicine.drug
Abstract: Background/aim Cytomegalovirus (CMV) replication may cause life-threatening complications after allogeneic haematopoietic stem cell transplantation (allo-HSCT). The aim of the study was to characterize CMV events, and the outcome of letermovir (LTV) CMV prophylaxis. Patients and methods In this retrospective analysis of patients treated with an allo-HSCT between 2010 and 2020, we determined plasma CMV events, as well as associated risk factors. Results We identified 423 patients who had undergone allo-HSCT between 2010 and 2020. CMV DNAemia was found in 130/423 (30.7%) of patients. CMV reactivation rate was significantly higher in patients with acute graft-versus-host disease, HLA mismatch, and CMV IgG seropositivity of donors and recipients. Among 42 patients receiving LTV prophylaxis those, 5 (11.9%) showed CMV DNAemia under LTV versus 87/353 (24.6%) in a control group. Conclusion Despite the development of better approaches with weekly monitoring and early treatment initiation, CMV reactivations play an important role after allo-HSCT.
Published: 2020

38. Características epidemiológicas y microbiológicas de las infecciones urinarias no complicadas

Author: Tomás Amuchástegui, Esteban Foia, Daniela Hernández, Ricardo Arturo Albertini, Sofía Mariela Vázquez, Gabriela Estefanía Peñaranda, Emanuel José Saad, Ana Panchuck, María Fabiana Ellena Leon, David Francisco Suasnabar, Fernando Dominella, María Aldana Cometto, and Malena Finello
Subjects: cistitis, lcsh:R5-920, medicine.medical_specialty, business.industry, antiinfecciosos, lcsh:R, lcsh:Medicine, General Medicine, Bacteriuria, medicine.disease, Asymptomatic, Ciprofloxacin, pielonefritis, Nitrofurantoin, Internal medicine, Ampicillin, Epidemiology, medicine, Ceftriaxone, infecciones urinarias, Coagulase, medicine.symptom, lcsh:Medicine (General), business, medicine.drug
Abstract: Introducción: Las infecciones del tracto urinario no complicadas (ITU-NoC) representan un motivo frecuente de consulta ambulatorio, siendo la mayoría tratadas empíricamente. Han existido cambios en susceptibilidad antimicrobiana en los últimos años. Nuestros objetivos fueron determinar los microorganismos de las ITU-NoC y su perfil de susceptibilidad antimicrobiana en mujeres adultas. Métodos: Estudio analítico prospectivo en dos hospitales de Córdoba, Argentina, entre noviembre/2016 y octubre/2017. A partir de la identificación de urocultivos positivos, se incluyeron las infecciones urinarias(ITUs) en mujeres ≥18 años, sin factores de riesgo para ITUs complicada, excluyéndose las bacteriurias asintomáticas. Resultados: Se identificaron 610 episodios de ITU-NoC, 382(63%) en
Published: 2020

39. Prenatal Diagnosis and Postnatal Outcome of Eight Cases with Criss-Cross Heart – A Multicenter Case Series

Author: Aline Wolter, Jan Degenhardt, Rüdiger Stessig, J. Ritgen, Roland Axt-Fliedner, Malena Götte, Hakan Akintürk, Viktoria Kuhn, Markus Khalil, Christian Enzensberger, C. Vorisek, and Andrii Kurkevych
Subjects: Heart Septal Defects, Ventricular, Heart Defects, Congenital, medicine.medical_specialty, Heart malformation, Prenatal diagnosis, Crisscross Heart, Ultrasonography, Prenatal, Pregnancy, Double outlet right ventricle, Prenatal Diagnosis, Internal medicine, medicine, Humans, Multicenter Studies as Topic, Radiology, Nuclear Medicine and imaging, Child, Retrospective Studies, medicine.diagnostic_test, business.industry, Infant, Gestational age, medicine.disease, Double Outlet Right Ventricle, Stenosis, medicine.anatomical_structure, cardiovascular system, Amniocentesis, Cardiology, Female, business, Fetal echocardiography, Situs solitus
Abstract: Criss-cross heart (CCH) is a rare congenital cardiac defect defined by crossing of ventricular inflow streams contributing to less than 0.1 % of all congenital heart anomalies. Due to its rarity and complexity, prenatal diagnosis in these patients remains challenging. We sought to describe prenatal findings and postnatal course in eight cases of prenatally diagnosed CCH. This is a retrospective case series of prenatally diagnosed CCH in three centers between 2010-2017. We reviewed fetal echocardiograms as well as postnatal clinical charts and surgical reports. 8 cases of CCH were included. The median gestational age at diagnosis was 27 weeks. 7 patients were found with situs solitus, one fetus with situs ambiguous. In all patients, the four-chamber view was abnormal. There was atrioventricular discordance in half of the patients, while all patients showed ventriculoarterial discordance. All patients were found with additional cardiac anomalies, including ventricular septal defect, double outlet right ventricle, right aortic arch, atrial septal defect and pulmonary stenosis. Three patients underwent amniocentesis without pathological findings. All patients were born alive at a median gestational age of 38 + 2 weeks and survived our median follow-up of 181 days. CCH can be diagnosed prenatally by detailed fetal echocardiography when observing an abnormal four-chamber view with crossing of inflow streams into both ventricles and a lack of parallel orientation of the atrioventricular valve axis due to a clockwise or counterclockwise rotation of the ventricular mass along its axis. With the help of prenatal ultrasound, parental guidance and counselling as well as postnatal pediatric cardiac management can be warranted.ZIEL: Das Criss-cross-Herz (CCH) ist eine seltene angeborene kardiale Fehlbildung, die durch die Kreuzung der Zuflüsse beider Ventrikel definiert ist. Sie macht weniger als 0,1 % aller kongenitalen Herzanomalien aus. Aufgrund dieser Seltenheit und Komplexität stellt die pränatale Diagnose bei den betroffenen Patienten eine Herausforderung dar. Wir möchten die vorgeburtlichen Befunde und den postnatalen Verlauf in 8 Fällen von pränatal diagnostiziertem CCH beschreiben. Dies ist eine retrospektive Fallserie von pränatal diagnostiziertem CCH in 3 Zentren zwischen 2010 und 2017. Wir überprüften fetale Echokardiogramme sowie postnatale Krankenakten und chirurgische Berichte. Eingeschlossen wurden 8 Fälle mit CCH. Bei Diagnose betrug das mediane Alter 27 Gestationswochen. Bei 7 Föten lag ein Situs solitus, bei einem Fötus ein Situs ambiguus vor. Alle Patienten hatten einen abnormalen 4-Kammer-Blick. Bei der Hälfte der Patienten bestand eine atrioventrikuläre Diskordanz, während alle Patienten eine ventrikuloarterielle Diskordanz aufwiesen. Alle Föten wiesen zusätzliche kardiale Anomalien auf, darunter einen Ventrikelseptumdefekt, einen rechten Ventrikel mit doppeltem Auslass, einen rechten Aortenbogen, einen Vorhofseptumdefekt und eine Lungenstenose. Bei 3 Patienten wurde die Amniozentese ohne pathologischen Befund durchgeführt. Alle Patienten wurden in der medianen Gestationswoche 38 + 2 lebend geboren und überlebten unsere mediane Nachbeobachtungsperiode von 181 Tagen. Die CCH kann pränatal durch eine detaillierte fetale Echokardiografie diagnostiziert werden, wenn ein abnormaler 4-Kammer-Blick mit Kreuzung der Zuflüsse beider Ventrikel vorliegt und eine fehlende parallele Orientierung der Atrioventrikularklappen-Achse aufgrund der Rotation der ventrikulären Masse entlang ihrer Achse im oder gegen den Uhrzeigersinn beobachtet wird. Mithilfe der pränatalen Sonografie kann die Betreuung und Beratung der Eltern sowie ein postnatales pädiatrisches Herzmanagement gewährleistet werden.
Published: 2020

40. Neuropatía periférica como manifestaciónunica de poliangeítis microscópica en la altura. Reporte de caso

Author: María Rojas-Puertas, Amilcar Tinoco-Solórzano, Malena Roque-Poma, Carlos Camargo-Espinoza, and Leslie Ruiz-Marmolejo
Subjects: Pathology, medicine.medical_specialty, biology, business.industry, Incidence (epidemiology), medicine.disease, Small vessel vasculitis, Peripheral neuropathy, Myeloperoxidase, medicine, biology.protein, Rapidly progressive glomerulonephritis, General Agricultural and Biological Sciences, Positive serology, Microscopic polyangiitis, business, Anti-neutrophil cytoplasmic antibody
Abstract: La poliangeítis microscópica, es una vasculitis de vasos pequeños cuya incidencia es de 4 por 1 000 000 de habitantes y que frecuentemente se presenta asociada a manifestaciones de glomerulonefrítis rápidamente progresiva y capilaritis pulmonar. Las manifestaciones neurológicas son menos frecuentes. El diagnostico se confirma con serología positiva para Anticuerpos Anticitoplasma de neutrófilos (ANCA) y especificidad para patrón de fluorescencia perinuclear (P-ANCA) y Mieloperoxidasa (MPO). El tratamiento idóneo son los glucocorticoides e inmunosupresores. Se presenta el caso de un paciente de 69 años con poliangeitis microscópica que debuta con neuropatía periférica como única manifestación clínica, presentación que se considera atípica. Se plantea que ante la presencia de una neuropatía periférica aislada, deben efectuarse estudios para confirmar o descartar la presencia de Poliangeitis Microscópica en base a la gran variabilidad de su sintomatología clínica y potenciales formas de tratamiento.
Published: 2020

41. 'Immunising' physicians against availability bias in diagnostic reasoning

Author: Mamede, Sílvia, De Carvalho-Filho, Marco Antonio, De Faria, Rosa Malena Delbone, Franci, Daniel, Nunes, Maria Do Patrocinio Tenorio, Ribeiro, Ligia Maria Cayres, Biegelmeyer, Julia, Zwaan, Laura, Schmidt, Henk G., Educational and Developmental Psychology, and Research & Education
Subjects: Hepatitis, medicine.medical_specialty, 020205 medical informatics, business.industry, Health Policy, Psychological intervention, 02 engineering and technology, Jaundice, medicine.disease, Cognitive bias, 03 medical and health sciences, Patient safety, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Internal medicine, Test score, 0202 electrical engineering, electronic engineering, information engineering, medicine, 030212 general & internal medicine, medicine.symptom, Medical diagnosis, Viral hepatitis, business
Abstract: BackgroundDiagnostic errors have often been attributed to biases in physicians’ reasoning. Interventions to ‘immunise’ physicians against bias have focused on improving reasoning processes and have largely failed.ObjectiveTo investigate the effect of increasing physicians’ relevant knowledge on their susceptibility to availability bias.Design, settings and participantsThree-phase multicentre randomised experiment with second-year internal medicine residents from eight teaching hospitals in Brazil.InterventionsImmunisation: Physicians diagnosed one of two sets of vignettes (either diseases associated with chronic diarrhoea or with jaundice) and compared/contrasted alternative diagnoses with feedback. Biasing phase (1 week later): Physicians were biased towards either inflammatory bowel disease or viral hepatitis. Diagnostic performance test: All physicians diagnosed three vignettes resembling inflammatory bowel disease, three resembling hepatitis (however, all with different diagnoses). Physicians who increased their knowledge of either chronic diarrhoea or jaundice 1 week earlier were expected to resist the bias attempt.Main outcome measurementsDiagnostic accuracy, measured by test score (range 0–1), computed for subjected-to-bias and not-subjected-to-bias vignettes diagnosed by immunised and not-immunised physicians.ResultsNinety-one residents participated in the experiment. Diagnostic accuracy differed on subjected-to-bias vignettes, with immunised physicians performing better than non-immunised physicians (0.40 vs 0.24; difference in accuracy 0.16 (95% CI 0.05 to 0.27); p=0.004), but not on not-subjected-to-bias vignettes (0.36 vs 0.41; difference −0.05 (95% CI −0.17 to 0.08); p=0.45). Bias only hampered non-immunised physicians, who performed worse on subjected-to-bias than not-subjected-to-bias vignettes (difference −0.17 (95% CI −0.28 to −0.05); p=0.005); immunised physicians’ accuracy did not differ (p=0.56).ConclusionsAn intervention directed at increasing knowledge of clinical findings that discriminate between similar-looking diseases decreased physicians’ susceptibility to availability bias, reducing diagnostic errors, in a simulated setting. Future research needs to examine the degree to which the intervention benefits other disease clusters and performance in clinical practice.Trial registration number68745917.1.1001.0068.
Published: 2020

42. Protocolized emergency department observation care improves quality of ischemic stroke care in Haiti

Author: Shada A. Rouhani, Gene F. Kwan, Jeremiah D. Schuur, Keegan A. Checkett, Kathryn Anderson, Regan H. Marsh, Christopher W. Baugh, Aaron L. Berkowitz, Malena Outhay, Linda Rimpel, and Marie Cassandre Edmond
Subjects: medicine.medical_specialty, Original article, Observation unit, Psychological intervention, lcsh:Medicine, 03 medical and health sciences, 0302 clinical medicine, Geochemistry and Petrology, Medicine, 030212 general & internal medicine, Prospective cohort study, Stroke, Aspirin, lcsh:R5-920, business.industry, Emergency department, lcsh:R, 030208 emergency & critical care medicine, Overcrowding, medicine.disease, Haiti, Emergency medicine, Ischemic stroke, business, lcsh:Medicine (General), Gerontology, medicine.drug
Abstract: Introduction: In many low-income countries, Emergency Medicine is underdeveloped and faces many operational challenges including emergency department (ED) overcrowding and prolonged patient length of stays (LOS). In high-resource settings, protocolized ED observation unit (EDOU) care reduces LOS while preserving care quality. EDOUs are untested in low-income countries. We evaluate the effect protocolized EDOU care for ischemic stroke on the quality and efficiency of care in Haiti. Methods: We performed a prospective cohort study of protocolized observation care for ischemic stroke at a Haitian academic hospital between January 2014 and September 2015. We compared patients cared for in the EDOU using the ischemic stroke protocol (study group) to eligible patients cared for before protocol implementation (baseline group), as well as to eligible patients treated after protocol introduction but managed without the EDOU protocol (contemporary reference group). We analysed three quality of care measures: aspirin administration, physical therapy consultation, and swallow evaluation. We also analysed ED and hospital LOS as measures of efficiency. Results: Patients receiving protocolized EDOU care achieved higher care quality compared to the baseline group, with higher rates of aspirin administration (91% v. 17%, p
Published: 2020

43. Depression is associated with efavirenz-containing treatments in newly antiretroviral therapy initiated HIV patients in Ecuador

Author: Malena Camacho, Alejandro Checa, Alberto Castillo, Isabel Hernández, Enrique Teran, and William Tapia
Subjects: Adult, Cyclopropanes, Male, lcsh:Immunologic diseases. Allergy, medicine.medical_specialty, Efavirenz, Anti-HIV Agents, Short Report, HIV Infections, Newly diagnose, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Acquired immunodeficiency syndrome (AIDS), Rating scale, Virology, Internal medicine, Medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Depression (differential diagnoses), business.industry, Depression, Hamilton Rating Scale for Depression, HIV, medicine.disease, Antiretroviral therapy, Benzoxazines, chemistry, Alkynes, Molecular Medicine, Reverse Transcriptase Inhibitors, Female, Ecuador, business, lcsh:RC581-607, 030217 neurology & neurosurgery, Cohort study
Abstract: Background It is well known that people living with HIV (PLWH) is in higher risk for the development of depression and it has also been suggested that the use of efavirenz into the antiretroviral regimens increases even that risk. Objective To evaluate the effect of efavirenz-containing antiretroviral regimens on the development of depression in newly ART initiated HIV patients in Ecuador. Methods In a prospective cohort study from June 2016 to May 2017, all newly HIV diagnosed patients at the HIV/AIDS Unit of the Hospital Eugenio Espejo in Quito, Ecuador were evaluated using the Hamilton Rating Scale for Depression followed by a second assessment 8–12 weeks after antiretroviral therapy containing efavirenz was initiated. Results A total of 79 patients, mainly males younger than 35 years were studied. Majority of them were on TDF/FTC/EFV. Initial score in Hamilton Rating Scale revealed that less than 30% had no depression symptoms while almost 40% had mild depression. However, in the second assessment, 22.6% of the subjects had a score in the Hamilton Rating Scale compatible with severe or very severe depression (RR 1.58, 95% CI 1.09 to 2.28; p = 0.05). Conclusion In our cohort study, depression was much higher in patients on Efavirenz-containing treatments. Therefore, assessment for depression must be essential as part of follow-up in these patients.
Published: 2020

44. A sialidosis type I cohort and a quantitative approach to multimodal ophthalmic imaging of the macular cherry-red spot

Author: Cynthia J. Tifft, Laryssa A. Huryn, Catherine Groden, Jean M. Johnston, Wadih M. Zein, Camilo Toro, Malena Daich Varela, Alessandra d'Azzo, and Edmond J. FitzGibbon
Subjects: Adult, Male, medicine.medical_specialty, Visual acuity, genetic structures, Adolescent, Fundus Oculi, Visual Acuity, Multimodal Imaging, Retina, Imaging, Cellular and Molecular Neuroscience, NEU1, Young Adult, Atrophy, Optical coherence tomography, Retinal Diseases, Mucolipidoses, Ophthalmology, medicine, Genetics, Humans, Macula Lutea, Sialidosis, Fluorescein Angiography, Child, medicine.diagnostic_test, business.industry, Macula, Clinical Science, medicine.disease, Sensory Systems, eye diseases, medicine.anatomical_structure, Cohort, Female, sense organs, Diagnostic tests/Investigation, medicine.symptom, business, Galactosialidosis, Tomography, Optical Coherence
Abstract: AimTo describe the ophthalmologic findings on the largest cohort of patients with sialidosis type I due to deficiency of the lysosomal sialidase, neuraminidase 1 (NEU1) and to introduce a quantitative neuroretinal image analysis approach to the associated ‘macular cherry-red spot’.MethodsSeven patients with sialidosis type I (mutations in NEU1) and one with galactosialidosis (mutations in CTSA) were included. All patients underwent detailed ophthalmological examinations. The reflectivity of macular optical coherence tomography (OCT) was measured using greyscale analysis (Fiji) and compared with age-matched healthy volunteers. Four patients were evaluated over a time of 1.5+0.5 years.ResultsThe mean age of the patients at their first visit was 27.5+9.8 years. All patients had a macular cherry-red spot, clear corneas and visually non-significant lenticular opacities. The mean visual acuity was LogMar 0.4 (20/50)+0.4 (20/20 to 20/125). Six patients had good visual function. Optic atrophy was present in two individuals with reduced acuity. A significant increase in macular reflectivity was present in all patients compared to age-matched controls (pConclusionMost of our patients (75%) have preserved visual acuity, even in adulthood. The presence of optic atrophy is associated with poor visual acuity. Increased macular reflectivity by OCT greyscale measurements is noted in all patients, although the underlying biological basis is unknown. These findings complement the current methods for examining and monitoring disease progression, especially in patients for whom visualisation of the cherry-red spot is not entirely clear.Trial registration numberNCT00029965.
Published: 2020

45. Arco Palmar Superficial: Redefiniendo un Clásico

Author: Rafael Gigena, Aldana Paula Hamermiler, Esteban Blasi, Nicolás Martin Trupia, Pablo Andrés Martinez-Hinojosa, Manuel Ignacio Lopez-Miná, Vicente Hugo Bertone, Lucila Pulice, Sergio Shinzato, and Malena Pangol-Lupi
Subjects: business.industry, medicine.artery, medicine, Arco palmar superficial, Anatomy, Radial artery, Anatomía, business, Anatomic Variation, Arteria ulnar, Ulnar artery
Abstract: RESUMEN: El arco palmar superficial (APS) resulta de la unión de la arteria ulnar y la rama palmar superficial de la arteria radial. Por su convexidad nacen las arterias digitales comunes. Esta descripción es la única que distintos autores han tomado como válida, por lo que se espera encontrarla durante la disección con mayor frecuencia. Esto no ha sido verificado en nuestra experiencia. Nos proponemos llevar a cabo una revisión de la descripción del APS poniéndolo en contraposición con las disecciones realizadas. Se disecaron y analizaron 61 manos cadavéricas. Estudio del arco palmar superficial: Variante clásica del APS: 23 casos (37,7 %). Variante no clásica del APS: 15 casos (24,6 %). Tipo A: 13 casos (86,7 %). Anastomosis entre arterias ulnar y metacarpiana dorsal del primer espacio. Tipo B: 2 casos (13,3 %). Anastomosis entre arterias ulnar y satélite del nervio mediano. Ausencia del arco: 23 casos (37,7 %) Tipo A: 19 casos (82,6 %). La arteria ulnar es la única estructura en el plano del APS. Tipo B: 3 casos (13 %). La arteria ulnar y la rama palmar superficial de la arteria radial están en el plano del APS sin anastomosarse entre sí. Tipo C: 1 caso (4,4 %). La arteria ulnar y la satélite del nervio mediano están en el plano del APS sin anastomosarse. Estudio de la quinta arteria digital palmar común: La quinta arteria digital palmar común se originó de las distintas variantes en 41 casos (67,2 %). Recomendamos al momento de la disección considerar que: la variante clásica no es la más frecuente de hallar; la ausencia del arco se verifica en el mismo porcentaje que la variante clásica; incluso cuando se comprueba la presencia del APS, el porcentaje de la variante no clásica es contundente; la quinta arteria digital palmar común es una rama colateral constante del APS.
Published: 2020

46. Hydrocarbon Intoxication in Children

Author: David Rekhtman, Diana Aberbuch, Rotem Rephaeli, Malena Cohen-Cymberknoh, and Ariel Tenenbaum
Subjects: Male, Pediatrics, medicine.medical_specialty, Kerosene, Chemical pneumonitis, medicine, Humans, Ingestion, Child, Pathological, business.industry, Poisoning, Clinical course, Conscious State, Pneumonia, General Medicine, medicine.disease, University hospital, Hydrocarbons, Anti-Bacterial Agents, Hospitalization, Pediatrics, Perinatology and Child Health, Emergency Medicine, Vomiting, Female, medicine.symptom, business
Abstract: OBJECTIVES Hydrocarbon intoxication in children still occurs, although it is preventable. It may cause a variety of clinical manifestations, involving the respiratory system and the nervous system. Our goal was to investigate all cases of hydrocarbon poisoning in children hospitalized in the Hadassah-Hebrew university hospitals in Jerusalem due to exposure to hydrocarbon in 2 decades. METHODS We retrieved the clinical and sociodemographic characteristics of all children who were admitted to our hospitals because of hydrocarbon intoxication in 2 decades. RESULTS One hundred seventy-two children were hospitalized, primarily because of ingestion of kerosene. In most cases, the poisons were stored in a bottle or other easily accessible container. Boys were more likely than girls to be hospitalized. Most of the children were of Arab origin in families with more than 3 children. Coughing, vomiting, and a decrease in conscious state were common at presentation, followed by fever and dyspnea. The clinical course was usually mild to moderate and self-resolving. Some children were treated with oxygen, fluids, and antibiotics. The main result of hydrocarbon poisoning was chemical pneumonitis, and many had pathological chest x-rays. Only one severe case resulted in death. CONCLUSIONS Hydrocarbon intoxication results in a variety of clinical manifestations and can be life-threatening. Most cases of poisoning could have been easily prevented if the substances were kept out of the reach of children.
Published: 2020

47. ‘Keep watch’ around water: short-term impact of a Western Australian population-wide television commercial

Author: Justine E. Leavy, Gemma Crawford, Michael Casten, Lauren Nimmo, Sarah French, Jonine Jancey, and Malena Della Bona
Subjects: medicine.medical_specialty, 030503 health policy & services, Public health, Public Health, Environmental and Occupational Health, Grandparent, Hierarchy of effects, Advertising, Home setting, Term (time), Comprehension, 03 medical and health sciences, 0302 clinical medicine, Time frame, Australian population, medicine, 030212 general & internal medicine, 0305 other medical science, Psychology
Abstract: Water safety mass-media campaigns are used in public health though few are reported on in the literature. A key component is the use of television commercials (TVCs) to promote supervision of children in and around water. This article reports on the proximal impacts—awareness, comprehension, acceptance and intention—of two new Keep Watch TVCs, aired in Western Australia during the summer of 2017/18. Post-campaign, cross-sectional data were collected via online and intercept surveys. Data were collected between February and April 2018 (9 weeks). Self-reported responses (n = 257) from adults who were a parent/grandparent/carer of a child < 5 years old in a home setting were evaluated to assess campaign awareness, comprehension, acceptance and intention consistent with a hierarchy of effects and monitoring of media effects approach. Campaign awareness was 32.3% and comprehension was 83.0% TVC1 and 82.1% TVC2. Of those who comprehended the TVC messages 50% intended to take action. Findings demonstrated modest but positive campaign effects, given the relatively short time frame and limited media spend. This study is one of few water safety media campaigns to provide insights into awareness, comprehension, intention and acceptability of mass-media campaigns to prevent drowning. Findings suggest traditional media continue to play a role in reinforcing drowning prevention messages to parents particularly in increasing awareness of how to keep children safe in and around water.
Published: 2020

48. Atrial and Ventricular Deformation Analysis in Normal Fetal Hearts Using Two-Dimensional Speckle Tracking Echocardiography

Author: Christian Enzensberger, Aline Wolter, Malena Götte, Oliver Graupner, Roland Axt-Fliedner, Markus Meister, and Viktoria Kuhn
Subjects: Embryology, medicine.medical_specialty, Heart Ventricles, Diastole, Gestational Age, Speckle tracking echocardiography, Ultrasonography, Prenatal, Basal (phylogenetics), Fetal Heart, Pregnancy, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Heart Atria, Retrospective Studies, Fetus, medicine.diagnostic_test, business.industry, Ultrasound, Obstetrics and Gynecology, Gestational age, General Medicine, Echocardiography, Doppler, ddc, medicine.anatomical_structure, Ventricle, Pediatrics, Perinatology and Child Health, Cardiology, Female, business, Fetal echocardiography
Abstract: Objective: Two-dimensional speckle tracking echocardiography (2D-STE)-based strain values of the left and the right ventricle have been established; however, less is known about atrial deformation. The aim of our study was to assess both atrial strain and ventricular strain using 2D-STE in a cardiac 4-chamber view and to investigate the effect of possible influencing factors such as gestational age. Methods: Fetal echocardiography was performed on a Toshiba Aplio 500 ultrasound system. Based on an apical or basal 4-chamber view of the fetal heart, left and right ventricular longitudinal peak systolic strain (LVLPSS and RVLPSS) as well as left and right atrial longitudinal peak systolic strain (LALPSS and RALPSS) were assessed by 2D-STE. Results: A total of 101 healthy fetuses were included. The mean gestational age (GA) was 26.0 ± 5.6 weeks. GA was significantly positively correlated (p < 0.05) with LVLPSS and RVLPSS and significantly negatively correlated (p < 0.05) with LALPSS and RALPSS. The mean values for LVLPSS and RVLPSS were −17.44 ± 2.29% and −16.89 ± 1.72%. The mean values for LALPSS and RALPSS were 34.09 ± 4.17% and 35.36 ± 2.90%. Conclusion: Ventricular and atrial deformation analysis in 2D-STE was technically feasible and showed comparable values to current data. For future research on myocardial function (MF) of the fetus, considering GA as an influencing factor for deformation analysis seems to be adequate. Especially, atrial deformation analysis allows the assessment of diastolic myocardial function. Further research needs to clarify the clinical meaning of these myocardial deformation indices in fetuses at risk.
Published: 2020

49. Caracterização das reações adversas a quimioterápicos em um hospital filantrópico

Author: Geraldo Bezerra da Silva Junior, Rosa Malena Fagundes Xavier, Mariana Bezerra Tavares, Jamile Rocha de Oliveira, Maria Teresita Bendicho, and Valnélia Fraga da Silva
Subjects: Gynecology, medicine.medical_specialty, business.industry, medicine, General Medicine, business
Abstract: Introducao: O acompanhamento e assistencia prestada pela equipe mutidisciplinar de saude possibilitam a ampliacao dos cuidados em saude aos pacientes, principalmente aqueles em tratamento antineoplasico ambulatorial, uma vez que promovem a reducao de RAMs e trazem melhorias na adesao terapeutica. Objetivo: Caracterizar as reacoes adversas moderadas a grave (graus 3 e 4) aos quimioterapicos dos pacientes oncologicos em tratamento ambulatorial, promovendo a necessidade da atuacao do profissional farmaceutico. Materiais e Metodos: Trata-se de um estudo descritivo de carater transversal-retrospectivo, com a avaliacao de indicadores sobre RAMs e dos prontuarios eletronicos dos pacientes oncologicos em tratamento ambulatorial de um Hospital Filantropico, de janeiro de 2016 a dezembro de 2017. A pesquisa foi aprovada pelo Comite de Etica em Pesquisa, conforme o no do parecer 2.670.217/2018. Resultados e Discussao: No periodo do estudo, 63 pacientes apresentaram RAMs moderadas a grave (graus 3 e/ou 4), a maioria dos pacientes eram do sexo feminino (52%), casadas (23%), encontrando-se na faixa etaria de 40 a 59 anos (41%) e de 60 a 89 anos (41%), tendo cursado ate o nivel medio (26%). As RAMs mais incidentes foram anemia grau 3 (23%), seguida por neutropenia febril grau 3 (21%), diarreia e leucopenia graus 3 (7%) e rash acneiforme grau 3 (8%), o protocolo neoplasico mais envolvido no aparecimento destas foi o FOLFOX (22%) e a maioria dos pacientes (96%) tiveram reconciliacao medicamentosa e adesao terapeutica (73%), no periodo estabelecido do estudo. Conclusao: O acompanhamento pela equipe multidisciplinar em oncologia auxilia no desenvolvimento da qualidade do cuidado em saude do paciente, com o intuito de reduzir efeitos adversos aos medicamentos, instituindo medidas preventivas, dentre outras, por meio da conciliacao medicamentosa e intervencoes clinicas.
Published: 2020

50. Sífilis secundaria, 590 dilemas resueltos

Author: Viviana Leiro, Alcira Bermejo, Mariel McGuire, Mercedes Solís Ramírez, Liliana Olivares, and Malena Colasanti
Subjects: Gynecology, medicine.medical_specialty, business.industry, Estudio transversal, Dermatology, Secondary syphilis, medicine.disease, World health, Large cohort, Medicine, Syphilis, In patient, business, Early syphilis
Abstract: espanolIntroduccion: La Organizacion Mundial de la Salud (OMS) hasta agosto de 2016 reporto que cada ano 5.6 millones de personas contraen sifilis en todo el mundo. En la actua-lidad, existe un incremento global de la incidencia de la enfermedad, que es constante en la ultima decada. La sifilis secundaria es la etapa de la enfermedad conocida como «la gran simuladora», debido al polimorfismo que muestra en sus diversas formas de presentacion, lo que suele dificultar el diagnostico con el agravante de la infectividad que representa este estadio de la enfermedad. Objetivos: Mostrar las formas actuales de presentacion de la sifilis secundaria de acuerdo con lo observado en la seccion de Enfermedades de Transmi-sion Sexual (ETS) en un hospital de enfermedades infecciosas en la Ciudad Autonoma de Buenos Aires (CABA), a la luz del aumento creciente de casos de la enfermedad. Observar el diverso espectro de presentacion y establecer diferentes parametros identificatorios de la enfermedad que puedan orientar por su sola presencia a la sifilis secundaria. Material y metodos: Se realizo estudio transversal de los casos de sifilis diagnosticados entre marzo de 2014 y marzo de 2017 en el sector de ETS. Los pacientes fueron evaluados segun edad, genero, sexualidad y formas clinicas de presentacion. Resultados: Se diagnosticaron 1,236 casos de sifilis tempra-na. La prevalencia de sifilis secundaria fue de 48%. Setenta por ciento de los afectados eran hombres. Cuarenta y nueve por ciento de los casos de ambos sexos se presentaron en la franja de entre 20 y 30 anos. El 68% de los enfermos refirio ser heterosexual. El 44% de los afectados tuvo compromiso cutaneo mucoso, 28% solo mostro compromiso de mucosas y 47% presento adenopatias perifericas. Conclusion: Esta numerosa cohorte, la mayor de acuerdo con la bibliografia publicada a la fecha, muestra una incidencia sostenida de sifilis secundaria en un hospital publico. Se destaca que ante la aparicion de exantema con o sin compromiso mucoso y adenopatias se debe pensar hoy mas que nunca en sifilis secundaria entre los diagnosticos diferenciales EnglishIntroduction: As reported by the World Health Organization (WHO), until August 2016, 5.6 million people were infected with syphilis every year. Currently, there is a global increase in the incidence of the disease, which is constant in the last decade. Secondary syphilis is the stage of the disease known as «the great imitator», due to the polymorphism that it shows in its various forms of presentation, which usually makes diagnosis difficult with the aggravating factor of the infectivity that represents this stage of the disease. Objectives: To show the current forms of presentation of the secondary syphilis according to what was observed in the Sexually Transmitted Diseases (STDs) section in a hospital of infectious diseases in the Autonomous City of Buenos Aires (CABA), in light of the increasing number of cases of the disease. To observe the diverse spectrum of presentation and to establish different identifying parameters of the disease which can orient, by its simply presence, to the identification of secondary syphilis. Material and methods: a cross-sectional study of the cases of syphilis diagnosed between March 2014 and March 2017 in the STD section was carried out. The patients were evaluated according to age, gender, sexuality and clinical forms of presentation. Results: 1,236 cases of early syphilis were diagnosed. Prevalence of secondary syphilis was 48%. 70% were men, 49% of both genders were between 20 and 30 years old.Sixty-eight percent (68%) of the patients reported to be heterosexual. Forty-four percent (44%) had mucosal and cutaneous manifestations, while 20% showed only mucosal manifestations and 47% had peripheral adenopathies. Conclusion: This large cohort, the largest according to the bibliography published to date, shows a sustained incidence of secondary syphilis in patients of a public hospital. It is important to emphasize that in the presence of exanthema, with or without mucosal compromise and adenopathy, secondary syphilis should be considered as part of the differential diagnosis
Published: 2020

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