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4 results on '"MESH : Lymphoma"'

1. Biosimilars of filgrastim in autologous stem cell transplant: reduction in granulocyte-colony stimulating factor costs, but similar effects on bone marrow recovery

Author

Christian Berthou, Marie-Anne Couturier, Pascal Delépine, Jean-Christophe Ianotto, Françoise Ngo Sack, Adrian Tempescul, Nathalie Mugnier, Gaelle Guillerm, Service Hématologie, Hôpital Morvan [Brest]-Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Hematology service, Hôpital Central de Yaoude, Immunologie et Pathologie ( EA2216 ), Université de Brest ( UBO ) -IFR148, Laboratoire de Biométrie et Biologie Evolutive ( LBBE ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique ( Inria ) -Centre National de la Recherche Scientifique ( CNRS ), Université européenne de Bretagne ( UEB ), Hôpital Morvan [Brest]-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Eléments transposables, évolution, populations, Département génétique, interactions et évolution des génomes [LBBE] (GINSENG), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Université européenne de Bretagne - European University of Brittany (UEB), and Michel, Geneviève

Subjects
Male, Oncology, Cancer Research, Lymphoma, MESH : Retrospective Studies, MESH : Aged, MESH: Multiple Myeloma, MESH: Recombinant Proteins, MESH : Granulocyte Colony-Stimulating Factor, MESH: Drug Costs, hemic and lymphatic diseases, Granulocyte Colony-Stimulating Factor, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, MESH : Female, Prospective cohort study, MESH: Treatment Outcome, MESH: Aged, MESH: Middle Aged, Hematopoietic Stem Cell Transplantation, Biosimilar, Hematology, Middle Aged, MESH : Adult, Recombinant Proteins, MESH: Transplantation, Autologous, 3. Good health, Granulocyte colony-stimulating factor, Treatment Outcome, medicine.anatomical_structure, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Multiple Myeloma, medicine.drug, Adult, medicine.medical_specialty, MESH : Transplantation, Autologous, [SDV.IMM] Life Sciences [q-bio]/Immunology, Filgrastim, MESH: Biosimilar Pharmaceuticals, MESH : Recombinant Proteins, MESH : Male, MESH : Treatment Outcome, Transplantation, Autologous, MESH : Lymphoma, Drug Costs, MESH : Drug Costs, MESH : Hematopoietic Stem Cell Transplantation, Internal medicine, medicine, Humans, MESH : Middle Aged, Biosimilar Pharmaceuticals, MESH: Hematopoietic Stem Cell Transplantation, Aged, Retrospective Studies, MESH: Humans, business.industry, MESH : Humans, MESH: Adult, MESH: Retrospective Studies, Retrospective cohort study, medicine.disease, MESH: Male, Surgery, Transplantation, MESH : Biosimilar Pharmaceuticals, MESH: Granulocyte Colony-Stimulating Factor, Bone marrow, MESH: Lymphoma, MESH : Multiple Myeloma, business, MESH: Female
Abstract

International audience; Granulocyte-colony stimulating factors (G-CSFs) enhance bone marrow (BM) recovery after autologous stem cell transplant (ASCT) in patients with lymphoma and myeloma. Few publications exist that discuss the use of filgrastim biosimilars after ASCT. We conducted a single-center retrospective study in patients with lymphoma and myeloma treated at Brest Hospital to assess the cost reductions related to and the efficiency and safety of filgrastim biosimilars. We identified 65 patients with lymphoma or myeloma treated with filgrastim biosimilars for ASCT and compared 19 parameters of these patients, including BM recovery, side effects, infectious complications and treatment costs, with published historical data on a cohort of 50 patients treated with classic filgrastim. We observed a significant reduction of G-CSF costs in both groups but did not observe a change in total hospitalization costs (representing less than 2% of the costs) between groups. Additionally, we did not observe differences between the two groups in BM recovery, infectious complications, side effects or the other studied parameters. In this retrospective study, the absence of differences between groups after ASCT in lymphoma and myeloma led us to believe that these drugs could be safely and effectively used for such indications without a significant impact on hospitalization costs. A prospective study should be conducted to confirm our results.

Published
2013
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2. Human Blood-Brain Barrier Disruption by Retroviral-Infected Lymphocytes: Role of Myosin Light Chain Kinase in Endothelial Tight-Junction Disorganization

Author

Marie-Christine Prévost, Christine Schmitt, Simona Ozden, Antoine Gessain, Babette B. Weksler, Pierre-Emmanuel Ceccaldi, Philippe V. Afonso, Pierre-Olivier Couraud, Ignacio A. Romero, Danielle Seilhean, Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Microscopie électronique (Plate-forme), Institut Pasteur [Paris], CHU Pitié-Salpêtrière [APHP], Weill Medical College of Cornell University [New York], Institut Cochin (UMR_S567 / UMR 8104), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Department of Biological Sciences, The Open University [Milton Keynes] (OU), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur [Paris] - Centre National de la Recherche Scientifique (CNRS), Laboratoire de Neuropathologie, Hôpital de la Salpétrière, and Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)

Subjects
Pathology, MESH : Cerebellum, [SDV]Life Sciences [q-bio], MESH : Lymphocytes, MESH : Herpesviridae Infections, MESH : Models, Immunological, MESH : Herpesvirus 8, Human, MESH : Blood-Brain Barrier, 0302 clinical medicine, Cerebellum, Interleukin-1alpha, Tropical spastic paraparesis, Immunology and Allergy, Lymphocytes, Transcellular, Cell Line, Transformed, MESH : Tumor Necrosis Factor-alpha, Human T-lymphotropic virus 1, 0303 health sciences, MESH : Neoplasm Recurrence, Local, Tight junction, MESH : Neurodegenerative Diseases, MESH : Cell Line, Transformed, Neurodegenerative Diseases, MESH : Human T-lymphotropic virus 1, Paraparesis, Tropical Spastic, 3. Good health, Cell biology, MESH : Pleural Effusion, Malignant, medicine.anatomical_structure, Spinal Cord, Blood-Brain Barrier, Paracellular transport, Infiltration (medical), medicine.medical_specialty, Myosin light-chain kinase, Endothelium, Immunology, MESH : Lymphoma, AIDS-Related, Biology, MESH : Myosin-Light-Chain Kinase, MESH : Lymphoma, Myosin light chain kinase activity, Tight Junctions, 03 medical and health sciences, medicine, Humans, MESH : Interleukin-1alpha, Myosin-Light-Chain Kinase, 030304 developmental biology, MESH : Tight Junctions, Tumor Necrosis Factor-alpha, MESH : Endothelial Cells, MESH : Humans, Models, Immunological, Endothelial Cells, Membrane Proteins, MESH : Spinal Cord, Phosphoproteins, medicine.disease, MESH : Paraparesis, Tropical Spastic, MESH : Endothelium, Vascular, MESH : Membrane Proteins, Zonula Occludens-1 Protein, Endothelium, Vascular, MESH : Phosphoproteins, 030217 neurology & neurosurgery
Abstract

The blood-brain barrier (BBB), which constitutes the interface between blood and cerebral parenchyma, has been shown to be disrupted during retroviral associated neuromyelopathies. Human T cell leukemia virus (HTLV-1)-associated myelopathy/tropical spastic paraparesis is a slowly progressive neurodegenerative disease, in which evidence of BBB breakdown has been demonstrated by the presence of lymphocytic infiltrates in the CNS and plasma protein leakage through cerebral endothelium. Using an in vitro human BBB model, we investigated the cellular and molecular mechanisms involved in endothelial changes induced by HTLV-1-infected lymphocytes. We demonstrate that coculture with infected lymphocytes induces an increase in paracellular endothelial permeability and transcellular migration, via IL-1α and TNF-α secretion. This disruption is associated with tight junction disorganization between endothelial cells, and alterations in the expression pattern of tight junction proteins such as zonula occludens 1. These changes could be prevented by inhibition of the NF-κB pathway or of myosin light chain kinase activity. Such disorganization was confirmed in histological sections of spinal cord from an HTLV-1-associated myelopathy/tropical spastic paraparesis patient. Based on this BBB model, the present data indicate that HTLV-1-infected lymphocytes can induce BBB breakdown and may be responsible for the CNS infiltration that occurs in the early steps of retroviral-associated neuromyelopathies.

Published
2007
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3. Pretransplant serum vitamin D levels and risk of cancer after renal transplantation

Author

Didier Ducloux, Cécile Courivaud, Jean-Marc Chalopin, Jamal Bamoulid, Amir Kazory, Gilles Dumoulin, Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC ( HOTE GREFFON ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Etablissement français du sang [Bourgogne-France-Comté] ( EFS [Bourgogne-France-Comté] ) -Université de Franche-Comté ( UFC ), Service de Néphrologie et Urologie, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Saint-Jacques, Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( PCVP / CARDIO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ) -Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Service d'urologie, andrologie et transplantation rénale, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques, Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( EA 3920) (PCVP / CARDIO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Saas, Philippe, Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), and Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) (PCVP / CARDIO)

Subjects
Male, Lung Neoplasms, Lymphoma, Gastroenterology, MESH: Kidney Transplantation, 0302 clinical medicine, Postoperative Complications, Risk Factors, MESH: Risk Factors, Neoplasms, MESH: Postoperative Complications, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, MESH: Neoplasms, MESH : Female, MESH: Incidence, 0303 health sciences, education.field_of_study, MESH: Middle Aged, Incidence (epidemiology), Incidence, Hazard ratio, MESH: Follow-Up Studies, Middle Aged, MESH : Adult, MESH : Risk Factors, Kidney Neoplasms, MESH: Predictive Value of Tests, MESH : Incidence, 3. Good health, 030220 oncology & carcinogenesis, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, MESH : Calcifediol, Adult, medicine.medical_specialty, [SDV.IMM] Life Sciences [q-bio]/Immunology, MESH: Calcifediol, MESH : Male, Population, MESH : Lymphoma, vitamin D deficiency, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, medicine, Vitamin D and neurology, Humans, MESH : Middle Aged, MESH : Predictive Value of Tests, MESH : Lung Neoplasms, Risk factor, education, 030304 developmental biology, Calcifediol, Transplantation, MESH: Humans, business.industry, MESH : Humans, MESH: Biological Markers, Cancer, MESH: Adult, MESH : Follow-Up Studies, medicine.disease, Kidney Transplantation, MESH : Neoplasms, MESH: Male, MESH : Kidney Neoplasms, MESH: Lung Neoplasms, MESH : Biological Markers, Endocrinology, MESH : Kidney Transplantation, MESH : Postoperative Complications, MESH: Kidney Neoplasms, business, MESH: Lymphoma, MESH: Female, Biomarkers, Follow-Up Studies
Abstract

International audience; BACKGROUND: Serum levels of 25-OH-D3 inversely correlate with the incidence of various types of cancers in the general population. Because risk factors and incidence of cancer in renal transplant recipients (RTRs) are different from the general population, this study was designed to determine whether pretransplant 25-OH-D3 levels could be predictive of cancer risk in RTRs. METHODS: Pretransplant 25-OH-D3 levels were reviewed in 363 consecutive RTRs. The impact of 25-OH-D3 levels on the development of cancer was then analyzed with respect to other known risk factors. RESULTS: One hundred twenty-four patients (34.2%) showed vitamin D deficiency, 185 (51%) vitamin D insufficiency, and 54 (14.8%) with normal vitamin D levels. Thirty-two cancers (8.8%) occurred in 32 patients. A higher incidence of cancer was observed in patients with vitamin D deficiency (13.7% vs. 7% for patients with vitamin D insufficiency [P=0.068] and 3.7% for those with normal vitamin D levels [P=0.007]). 25-OH-D3 levels were lower in patients who developed cancer after transplantation (13.7+/-6 vs. 18.3+/-17.8 ng/mL, P=0.022). Age (hazard ratio, 1.06; 95% confidence interval, 1.02-1.11, for each 1 year increase; P=0.009) and low 25-OH-D3 levels (hazard ratio, 1.12; 95% confidence interval, 1.04-1.23, for every 1 ng/mL decrease; P=0.021) were independent risk factors for development of cancer. CONCLUSION: Pretransplant level of 25-OH-D3 is an important determinant for subsequent development of cancer after transplantation. Future studies should examine whether 25-OH-D3 supplementation can effectively decrease the incidence of cancer in RTRs.

Published
2008
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4. Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis

Author

Marc Debouverie, Patrick Vermersch, Jérôme De Seze, Christine Lebrun, Arlette Danzon, Sandrine Wiertlevski, Frédéric Berthier, Lucien Rumbach, Pierre Clavelou, Olivier Gout, Gilles Defer, Laboratoire d'Imagerie et de Neurosciences Cognitives ( LINC ), Université Louis Pasteur - Strasbourg I-IFR37-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Neuroimagerie in Vivo ( LNV ), CHU Strasbourg-Centre National de la Recherche Scientifique ( CNRS ), Service de Neurologie, Fondation A. Rothschild, Département d'Informatique Médicale, CHU Nice-Hôpital Cimiez [Nice] ( CHU ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Laboratoire d'Imagerie et de Neurosciences Cognitives (LINC), Université Louis Pasteur - Strasbourg I-IFR37-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Neuroimagerie in Vivo (LNV), CHU Strasbourg-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital Cimiez [Nice] (CHU), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Université de Franche-Comté (UFC)

Subjects
Male, Skin Neoplasms, MESH : Multiple Sclerosis, MESH : Urologic Neoplasms, MESH : Breast Neoplasms, Digestive System Neoplasms, MESH : Central Nervous System Neoplasms, MESH: Central Nervous System Neoplasms, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, Central Nervous System Neoplasms, 0302 clinical medicine, MESH: Genital Neoplasms, Female, MESH : Azathioprine, Azathioprine, MESH: Incidence, MESH : Immunosuppressive Agents, education.field_of_study, MESH: Middle Aged, MESH: Peptides, MESH : Peptides, Incidence, MESH : Incidence, 3. Good health, Neurology, 030220 oncology & carcinogenesis, MESH: Mitoxantrone, MESH: Immunosuppressive Agents, medicine.medical_specialty, Multiple Sclerosis, MESH : Genital Neoplasms, Female, 03 medical and health sciences, MESH : Interferon-beta, Humans, MESH : Middle Aged, Risk factor, education, Cyclophosphamide, MESH: Azathioprine, MESH: Humans, MESH: Interferon-beta, MESH : Leukemia, MESH : Humans, MESH: Cyclophosphamide, MESH: Adult, Glatiramer Acetate, Interferon-beta, medicine.disease, MESH : Neoplasms, Neurology (clinical), MESH : Digestive System Neoplasms, Mitoxantrone, Peptides, MESH: Lymphoma, MESH: Female, 030217 neurology & neurosurgery, Lymphoma, MESH: Registries, Risk Factors, MESH: Risk Factors, Neoplasms, MESH: Neoplasms, MESH : Female, Registries, MESH : Cyclophosphamide, Acute leukemia, Leukemia, MESH: Urologic Neoplasms, Incidence (epidemiology), Middle Aged, MESH : Adult, MESH : Risk Factors, Female, Immunosuppressive Agents, medicine.drug, Adult, Urologic Neoplasms, Genital Neoplasms, Female, MESH : Male, Population, Breast Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH : Lymphoma, Internal medicine, MESH: Leukemia, medicine, business.industry, MESH: Digestive System Neoplasms, Multiple sclerosis, MESH: Skin Neoplasms, MESH : Skin Neoplasms, Cancer, MESH: Multiple Sclerosis, MESH: Male, Surgery, MESH : Mitoxantrone, business, MESH: Breast Neoplasms, MESH : Registries
Abstract

Background Prior to the era of immunomodulating or immunosuppressive (IS) treatments Multiple Sclerosis (MS) was linked to reduced rates of cancer. Method A descriptive study of MS patients with a documented oncological event was performed. From 1 January 1995 to 30 June 2006, we collected and studied the profile of 7418 MS patients gathered from nine French MS centers. We evaluated the incidence of cancer in a Cancer Risk In MS Cohort. Results Thirty one patients (1.75%) with confirmed MS had a history of cancer: mean age at MS diagnosis of 37.9 years and a mean age at cancer diagnosis of 46.4 years. The most frequent cancers were breast (34.5%), gynecological (12.5%), skin (10.2%), acute leukemia and lymphoma (5.9%), digestive (8.8%), kidney and bladder (5.1%), lung (3.4%) and central nervous system (3%). Calculated standardized incidence rates were 0.29 (0.17—0.45) for men and 0.53 (0.42—0.66) for women. The incidence of cancer in this MS population was lower than that expected for the general population. Matched to age, gender and histology, cancers in MS were associated with a young age and exposure to IS treatments. When considering all patients, treated patients had a 3-fold higher risk of developing cancer, if they had a history of IS ( P = 0.0035). For treated patients, the cancer sites were more likely the breast, the urinary tract, the digestive system and the skin. Conclusion Our data suggest that MS patients do not have an increased risk of cancer. Rather for several types of cancer a significantly reduced risk was observed, except for breast cancer in women treated with IS. The relative increased risk of breast cancer in MS women under IS treatment warrants further attention. Multiple Sclerosis 2008; 14: 399—405. http://msj.sagepub.com

Published
2008
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