14 results on '"M. S. Huang"'
Search Results
2. 4942Automated recognition of regional wall motion abnormalities by deep neural network interpretation of echocardiography
- Author
-
M S Huang and M R Tsai
- Subjects
Artificial neural network ,business.industry ,Medicine ,Pattern recognition ,Wall motion ,Artificial intelligence ,Cardiology and Cardiovascular Medicine ,business ,Interpretation (model theory) - Abstract
Background The deep neural network assisted in automated echocardiography interpretation joint to cardiologist final confirmation has now been gradually emerging. There were applications applied in echocardiography views classification, chamber size and myocardium mass evaluation, and certain disease detections already published. Our aim, instead of frame-by-frame “image-level” interpretation in previous studies, is to apply deep neural network in echocardiography temporal relationship analysis – “video-level” – and applied in automated left ventricle myocardium regional wall motion abnormalities recognition. Methods We collected all echocardiography performed in 2017, and preprocessed them into numeric arrays for matrix computations. Regional wall motion abnormalities were approved by authorized cardiologists, and processed into labels whether regional wall motion abnormalities presented in anterior, inferior, septal, or lateral walls of the left ventricle, as the ground truth. We then first developed a convolutional neural network (CNN) model to do view selection, and gathered parasternal long/short views, and apical four/two chamber views from each exam, as well as developing view prediction confidence for strict image quality control. Within these images, we annotated part of images to develop the second CNN model, known as U-net, for image segmentation and mark each regional wall. Finally, we developed the major three-dimensional CNN model with the inputs composed of four views of echocardiography videos and then output the final label for motion abnormalities in each wall. Results In total we collected 13,984 series of echocardiography, and gathered four main views with quality confidence level above 90%, which resulted in 9,323 series for training. Within these images, we annotated 2,736 frames for U-net model and resulted in dice score of segmentation 73%. With the join of segmentation model, the final three-dimensional CNN model predict regional wall motion with accuracy of 83%. Conclusions Deep neural network application in regional wall motion recognition is feasible and should mandate further investigation for promoting performance. Acknowledgement/Funding None more...
- Published
- 2019
- Full Text
- View/download PDF
Catalog
3. Elder Patients with Stage IV Lung Adenocarcinoma Harboring Rare EGFR Mutations Treated with a First-Line Tyrosine Kinase Inhibitor Might Have Better Outcome than Younger Patients
- Author
-
Ying-Ming Tsai, M.-S. Huang, Jen-Yu Hung, Y.W. Chung, Chih-Jen Yang, Mei-Hsuan Lee, Ming-Ju Tsai, and Y.-C. Tsai
- Subjects
Lung ,medicine.anatomical_structure ,Egfr mutation ,business.industry ,medicine.drug_class ,First line ,medicine ,Cancer research ,Adenocarcinoma ,Stage iv ,medicine.disease ,business ,Tyrosine-kinase inhibitor - Published
- 2019
- Full Text
- View/download PDF
4. Diabetes - experimental models
- Author
-
V. Blanco-Gozalo, A. Blazquez-Medela, O. Garcia-Sanchez, Y. Quiros, M. Montero, C. Martinez-Salgado, F. Lopez-Hernandez, J. Lopez-Novoa, L. Yao, Z. Qing, X. Hua, F. Min, M. Fei, W. Ning, V. Cantaluppi, F. Figliolini, M. Delena, S. Beltramo, D. Medica, C. Tetta, G. Segoloni, L. Biancone, G. Camussi, J. S. Cunha, V. M. Ferreira, M. A. Naves, M. A. Boim, T. Zitman-Gal, E. Golan, J. Green, M. Pasmanik-Chor, J. Bernheim, S. Benchetrit, M. Riera, S. Clotet, J. Pascual, M. Soler, K. Nakai, H. Fujii, K. Kono, S. Goto, M. Hirata, M. Shinohara, M. Fukagawa, S. Nishi, Q. Fan, S. Du, Y. Jiang, L. Wang, L. Fang, T. Radovits, M. M. Mozes, L. Rosivall, G. Kokeny, R. Aoki, R. Tateoka, F. Sekine, K. Kikuchi, Y. Yamashita, Y. Itoh, L. Cappuccino, G. Garibotto, E. D'Amato, B. Villaggio, F. Gianiorio, M. Mij, F. Viazzi, G. Salvidio, D. Verzola, A. Piwkowska, D. Rogacka, I. Audzeyenka, M. Kasztan, S. Angielski, M. Jankowski, E. W. Gaber, H. A. El-Attar, J. Liu, W. Zhang, Y. He, E. Macsai, Z. Takats, L. Derzbach, A. Korner, B. Vasarhelyi, M. S. Huang, H. Bo, F. Liu, P. Fu, N. E. Tsotakos, E. C. Tsilibary, G. I. Drossopoulou, N. Thawho, N. Farid, A. Peleg, A. Levy, N. Nakhoul, A. R. Lenghel, G. Borza, C. Catoi, C. I. Bondor, A. Muresan, I. M. Kacso, J.-S. Song, J.-H. Song, S.-H. Ahn, B. S. Choi, Y. a. Hong, M. Y. Kim, J. H. Lim, K.-S. Yang, S. Chung, S. J. Shin, H. W. Kim, Y. S. Chang, Y. S. Kim, C. W. Park, K. Takayanagi, H. Hasegawa, T. Shimizu, A. Ikari, C. Noiri, T. Iwashita, Y. Tayama, J. Asakura, N. Anzai, K. Kanozawa, H. Kato, T. Mitarai, M. Huang, R. H. Ashour, A. E.-M. M. Fouda, M. A. Saad, F. M. El-Banna, F. A. Moustafa, M. I. Fouda, M. D. Sanchez-Nino, A. B. Sanz, J. Poveda, M. Saleem, P. Mathieson, M. Ruiz-Ortega, R. Selgas, J. Egido, A. Ortiz, M. J. Soler, M. Rebull, E. Marquez, S. Okazaki, Y. Kogure, T. Sano, M. Hatano, E. Kreft, R. Kowalski, M. Szczepansk-Konkel, X. Liu, G. Yang, N. A. Osman, M. M. NasrAllah, M. M. Kamal, A. I. Ahmed, N. Fekih-Mrissa, M. Mrad, A. Baffoun, A. Sayeh, J. Hmida, N. Gritli, V. Galchinskaya, I. Topchii, P. Semenovykh, N. Yefimova, D. Zheng, D. Hu, X. Li, A. I. Peng, N. Olea-Herrero, M. Arenas, C. Munoz-Moreno, R. Moreno-Gomez-Toledano, M. Gonzalez-Santander, I. Arribas, and R. Bosch more...
- Subjects
Transplantation ,medicine.medical_specialty ,Nephrology ,business.industry ,Diabetes mellitus ,medicine ,Intensive care medicine ,medicine.disease ,business - Published
- 2013
- Full Text
- View/download PDF
5. The mode of reproductive-derived Spink (serine protease inhibitor Kazal-type) action in the modulation of mammalian sperm activity
- Author
-
Chung Mao Ou, S.-H. Li, S. Geetha, Jyh Bing Tang, P. S. Sudhakar Gandhi, M.-S. Huang, and Yee Hsiung Chen
- Subjects
Serine protease ,endocrine system ,education.field_of_study ,Protease ,urogenital system ,Urology ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Acrosome reaction ,Population ,Motility ,Biology ,Calcium in biology ,Cell biology ,Reproductive Medicine ,Biochemistry ,medicine ,biology.protein ,Protein phosphorylation ,Acrosome ,education ,reproductive and urinary physiology - Abstract
Summary The reproductive-derived serine protease inhibitor Kazal-type (Spink) has been identified in seminal plasma, and Spink–spermatozoa binding has been illustrated in many mammalian species including human. We used mice as experimental animal to study the mode of Spink action in the modulation of mammalian sperm activity. A Spink3-binding zone was cytochemically stained on the sperm head at apical hook separated from intact acrosome, whether the cells were capacitated or not. The Spink3–spermatozoa binding neither changed the population of cells in the uncapacitated, capacitated and acrosome-reacted status nor affected the capacitation-related protein phosphorylation and cell motility enhancement. Despite that, the Spink–spermatozoa interaction resulted in decreasing the intracellular calcium concentration ([Ca2+]i) of the cell head and suppressing both the acrosome reaction induced by Ca+2 ionophore A23187 and the cell fertility. Furthermore, Spink3 seen on the head of spermatozoa in the uterine cavity after coitus could be removed by the trypsin-like activity in the uterine fluid of oestrous females, and free Spink3 in the uterine cavity suppressed the protease activity. We integrated our data to shed light on the molecular mechanism of how Spink and its inhibiting protease are interplayed to modulate the activity of mammalian spermatozoa during their transit in the reproductive tract. more...
- Published
- 2011
- Full Text
- View/download PDF
6. Correlation of pulmonary 99mTc-DTPA ventilation and 99mTc-MAA perfusion scans with pulmonary function tests in asymptomatic asthmatic children
- Author
-
S.-H. Chou, Yu-Wen Chen, Jong-Hau Hsu, Jiunn-Ren Wu, Zen-Kong Dai, and M.-S. Huang
- Subjects
Male ,Spirometry ,medicine.medical_specialty ,Adolescent ,In Vitro Techniques ,Sensitivity and Specificity ,Ventilation/perfusion ratio ,Asymptomatic ,Pulmonary function testing ,Forced Expiratory Volume ,Internal medicine ,Administration, Inhalation ,Ventilation-Perfusion Ratio ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Child ,Radionuclide Imaging ,Lung ,Technetium Tc 99m Aggregated Albumin ,medicine.diagnostic_test ,Inhalation ,business.industry ,Reproducibility of Results ,General Medicine ,Asthma ,Respiratory Function Tests ,Injections, Intravenous ,Breathing ,Cardiology ,Technetium Tc 99m Pentetate ,Radiology ,Radiopharmaceuticals ,medicine.symptom ,business ,Airway ,Perfusion - Abstract
Our objective was to examine and correlate 99mTc-diethylenetriaminopentaacetic acid (99mTc-DTPA) ventilation and 99mTc-macroaggregated albumin (99mTc-MAA) perfusion (V/Q) lung scans with spirometry in asymptomatic asthmatic children. We evaluated 89 subjects (age range, 6-15 years; mean age, 9.4 years), all with at least 70% predicted forced expiratory volume in 1 s (FEV(1)). There were four V/Q scan patterns: normal in 38 (42.7%), inhomogeneous ventilation in 11 (12.4%), matched defects in 25 (28.3%) and mismatched perfusion defects in 13 (14.6%). The maximal mid-expiratory flow rate (MMEF) of the normal scan group was significantly different from that in the other groups. The MMEF of the inhomogeneous group was significantly different from that in the matched defect group and the mismatched perfusion defect group. No other significant differences in spirometric indices were found. In two children with perfusion defects, pulmonary arteriograms demonstrated no obstructive lesions. In conclusion, lung scans provide diagnostic information in asymptomatic asthmatic children, even when they are uncooperative. Abnormal scans are common in these children and are significantly correlated with reduced MMEF (% predicted), reflecting small airway flow obstruction. The pathophysiology of V/Q defects in asymptomatic asthmatic children warrants further investigation. more...
- Published
- 2003
- Full Text
- View/download PDF
7. Hepatic migration of a catheter fragment followed by disconnection of a totally implantable venous access port
- Author
-
M.-S. Huang, H.-C. Chen, S.-C. Chen, C.-S. Wang, and Chun-Yu Yang
- Subjects
Male ,medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,Embolism ,030232 urology & nephrology ,Biomedical Engineering ,Medicine (miscellaneous) ,Antineoplastic Agents ,Vena Cava, Inferior ,Bioengineering ,Hepatic Veins ,030204 cardiovascular system & hematology ,Saline flush ,Inferior vena cava ,Biomaterials ,03 medical and health sciences ,Catheters, Indwelling ,0302 clinical medicine ,Foreign-Body Migration ,medicine ,Humans ,Heart Atria ,Chemotherapy ,medicine.diagnostic_test ,business.industry ,Infusion Pumps, Implantable ,General Medicine ,Middle Aged ,Surgery ,Catheter ,medicine.anatomical_structure ,medicine.vein ,Equipment Failure ,business ,Chest radiograph ,Complication ,Subcutaneous tissue - Abstract
Totally implantable venous access ports (TIVAPs) are frequently used in oncology patients who require long-term courses of chemotherapy. We report a silent, but potentially hazardous complication of catheter fracture and hepatic migration in a 64-year-old male. The patient presented with a painful, rapid swelling of subcutaneous tissue around the port area during a saline flush. A chest radiograph showed that the disconnected catheter had separated from the port and was no longer in its original location. A chest CT scan revealed that the disconnected catheter was found to be embolized to the right atrium, inferior vena cava and right hepatic vein. The patient was treated successfully with percutaneous transfemoral retrieval of the catheter under fluoroscopic guidance. To our knowledge, there have been no previous reports of migration of the fractured catheter of a TIVAP into the right hepatic vein. This case highlights that the integrity of TIVAPs should be ascertained before chemotherapeutic drugs are administered. more...
- Published
- 2008
- Full Text
- View/download PDF
8. Upregulation of Functional Ryanodine Receptors duringin VitroAging of Human Diploid Fibroblasts
- Author
-
Samuel Goldstein, F A Lai, M S Huang, O Adebanjo, B S Moonga, David A. Lipschitz, and M Zaidi
- Subjects
medicine.medical_specialty ,Population ,Biophysics ,Fluorescent Antibody Technique ,Biology ,Biochemistry ,Cyclic ADP-ribose ,Antibodies ,chemistry.chemical_compound ,Downregulation and upregulation ,Caffeine ,Internal medicine ,medicine ,Humans ,education ,Receptor ,Molecular Biology ,Cellular Senescence ,Adenosine Diphosphate Ribose ,Cyclic ADP-Ribose ,education.field_of_study ,Ryanodine receptor ,Ryanodine Receptor Calcium Release Channel ,Cell Biology ,Fibroblasts ,Adenosine ,Up-Regulation ,Cell biology ,Cytosol ,Endocrinology ,Microscopy, Fluorescence ,chemistry ,Calcium ,Intracellular ,medicine.drug - Abstract
We demonstrate for the first time that cellular aging in vitro is accompanied by a dramatic elevation in the levels of ryanodine receptor-bearing Ca2+ channels. These channels normally reside within microsomal membranes and gate Ca2+ release from intracellular stores. We therefore measured cytosolic Ca2+ levels in 'young' (30 mean population doublings, MPDs) and 'senescent' (53 to 58 MPDs) human diploid fibroblasts (HDFs). Application of the known ryanodine receptor modulators, caffeine or cyclic adenosine diphosphate-ribose (cADPr), triggered cytosolic Ca2+ signals in both young and senescent cells. The signal magnitude however was significantly greater in senescent compared with young HDFs. In parallel, incubation with a highly specific anti-ryanodine receptor antiserum resulted in specific immunofluorescence only in senescent HDFs. We envisage that elevated levels of functional ryanodine receptors may underlie the defective Ca2+ handling and cellular degeneration that occurs with aging. more...
- Published
- 1998
- Full Text
- View/download PDF
9. CD1d1 displayed on cell size beads identifies and enriches an NK cell population negatively regulated by CD1d1
- Author
-
Peter Borszcz, Stephane Sidobre, Mitchell Kronenberg, Kevin P. Kane, and Michael M. S. Huang
- Subjects
Cytotoxicity, Immunologic ,Immunology ,Cell ,Down-Regulation ,Galactosylceramides ,Cell Communication ,Biology ,Lymphocyte Activation ,CD49b ,Antigens, CD1 ,Interleukin 21 ,Mice ,Receptors, KIR ,T-Lymphocyte Subsets ,Cell Line, Tumor ,medicine ,Immunology and Allergy ,Animals ,Receptors, Immunologic ,Receptor ,Antibodies, Blocking ,Cells, Cultured ,Cell Size ,Mice, Knockout ,Lymphokine-activated killer cell ,Janus kinase 3 ,Natural killer T cell ,Molecular biology ,Lymphocyte Subsets ,Microspheres ,Killer Cells, Natural ,Mice, Inbred C57BL ,medicine.anatomical_structure ,Interleukin 12 ,Interleukin-2 ,Female ,Antigens, CD1d ,Immunosuppressive Agents ,Protein Binding - Abstract
NK cells destroy microbe-infected cells while sparing healthy cells, and are controlled, in part, by inhibitory receptors specific for class I Ag-presenting molecules. CD1d1, a β2-microglobulin-associated class I-like molecule, binds glycolipids and stimulates NKT cells. We previously demonstrated that target cell lysis by IL-2-activated mouse NK cells is inhibited by target cell expression of CD1d1, suggesting that IL-2-activated NK cells may express a CD1d1-specific inhibitory receptor. We now report that a significant subset of mouse IL-2-activated NK cells specifically binds cell size beads displaying either naturally expressed or recombinant CD1d1. In contrast, although tetramers of soluble recombinant CD1d1 loaded with α-galactosylceramide identify NKT cells, binding of this reagent to resting or IL-2-activated NK cells was undetectable, even with activated NK cells sorted with CD1d1 beads. Cytotoxicity by the CD1d1 bead-separated NK subset was strongly inhibited by CD1d1, compared with the NK cell subset not bound to CD1d1 beads. An Ab that blocks NKT cell recognition of CD1d1 also reverses CD1d1 inhibition of NK lysis, suggesting that TCRs of NKT cells and NK inhibitory receptor(s) may interact with a similar site on CD1d1. These results provide direct evidence for a physical interaction of NK cells with CD1d1, mediated by a functional, CD1d1-specific low-affinity inhibitory NK receptor. Display of ligands on cell size beads to maximize multivalent interaction may offer an alternative approach to examine NK cell receptor-ligand interactions, particularly those of lower expression and/or lower affinity/avidity that may go undetected using tetrameric reagents. more...
- Published
- 2004
10. Effect of hepatocyte growth factor (HGF) on the proliferation of H441 human adenocarcinoma cells
- Author
-
T.-H Hsu, J.-J Hwang, H.-C Jao, C Hsu, J.-J Hou, J.-Y Hung, I.-W Chon, M.-S Tsai, E.-L Kao, and M.-S Huang
- Subjects
Pulmonary and Respiratory Medicine ,Cancer Research ,Oncology ,business.industry ,Cancer research ,Medicine ,Adenocarcinoma ,Hepatocyte growth factor ,business ,medicine.disease ,medicine.drug - Published
- 2000
- Full Text
- View/download PDF
11. CLINICAL STUDY ON EFFICACY OF NaHCO3-FREE ISOTONIC MEDIA (BFIM) FOR HUMAN CORNEA STORAGE
- Author
-
M. Y. Chen, M. S. Huang, S. H. Tseng, Stephen E. Orlin, G. Y. Hung, G. Rama, C. C. Wang, Paolo Rama, H. Lee, and Michael E. Sulewski
- Subjects
Clinical study ,Ophthalmology ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Cornea ,Isotonic ,Medicine ,business ,Surgery - Published
- 1997
- Full Text
- View/download PDF
12. Spirometry in life-long non-smoking, healthy Chinese women in Taiwan
- Author
-
M.-S. Tsai, H.-C. Lin, Inn-Wen Chong, J.-J. Hwang, M.-S. Huang, M.-S. Lin, and C.-S Lai
- Subjects
Spirometry ,Pulmonary and Respiratory Medicine ,Adult ,medicine.medical_specialty ,Vital capacity ,Vital Capacity ,Taiwan ,FEV1/FVC ratio ,Reference Values ,Forced Expiratory Volume ,Medicine ,Humans ,Lung ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Middle Aged ,respiratory system ,Body Height ,respiratory tract diseases ,Physical therapy ,Female ,business ,Demography ,circulatory and respiratory physiology - Abstract
To establish the spirometric values for normal, healthy Chinese women in Taiwan, the spirometry of 506 life-long non-smoking, healthy Chinese women was examined, including 140 subjects over the age of 60 years. Significant correlations among age, height and forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV 1 FVC % , peak expiratory flow (PEF), V max75 , V max50 , and V max25 were found. However, there were no significant correlations between age and FEV 1 FVC % , nor age and V max25 in the elderly group. FEV1 (FEV1∗) and FVC (FVC∗) were standardized to the overall mean height for elderly women using Cole's formula. The decline in FEV1∗ and FVC∗ with age were observed. The predicted value for the average 70-year-old woman with a height of 1·5 m derived from the present study is compared with those from other surveys of the elderly. The values from the present study are somewhat higher than the values from the Hong Kong study. The authors believe the fact that all of the present subjects were life-long non-smokers might explain the differences. more...
- Full Text
- View/download PDF
13. Comparison of cytokeratin fragment 19 (CYFRA 21-1), tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA) as tumour markers in bronchogenic carcinoma
- Author
-
Inn-Wen Chong, S.-B. Jong, M.-S. Tsai, H.-C. Lin, M.-S. Lin, J.-J. Hwang, and M.-S. Huang
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,Lung Diseases ,Male ,Pathology ,medicine.medical_specialty ,Lung Neoplasms ,Adolescent ,Tissue Polypeptide Antigen ,Adenocarcinoma ,Sensitivity and Specificity ,Cytokeratin ,Carcinoembryonic antigen ,Antigens, Neoplasm ,Carcinoma ,Biomarkers, Tumor ,Medicine ,Humans ,Carcinoma, Small Cell ,CYFRA 21-1 ,Aged ,Aged, 80 and over ,Keratin-19 ,Immunoradiometric assay ,biology ,business.industry ,Large cell ,Middle Aged ,medicine.disease ,Carcinoembryonic Antigen ,Carcinoma, Bronchogenic ,biology.protein ,Carcinoma, Squamous Cell ,Carcinoma, Large Cell ,Keratins ,Female ,Immunoradiometric Assay ,business - Abstract
To elevate the diagnostic value of the serum cytokeratin 19 fragment (CYFRA 21-1) and compare it with carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) in bronchogenic carcinoma, the sera of 161 patients (58 with benign pulmonary disease and 103 with bronchogenic carcinoma) was investigated using immunoradiometric assay. Sensitivities for CYFRA 21-1, CEA and TPA (using 3.5 ng ml-1, 5.0 ng ml-1, 110 U l-1, respectively, cut-off values corresponding to a 95% specificity for benign pulmonary disease) in bronchogenic carcinoma were 64, 47 and 61%, respectively. Positive CYFRA 21-1 levels were identified in 75% of patients with squamous cell carcinoma (n = 36), in 67% with adenocarcinoma (n = 45), in 17% with large cell carcinoma (n = 6), and in 50% with small cell lung cancer (SCLC) (n = 16). However, CYFRA 21-1 levels were not significantly different between squamous cell carcinoma and the other histological types. The sensitivity of the combined measurement of CYFRA 21-1 with any other tumour marker was significantly higher than that of CYFRA 21-1 measurement alone. Elevated CYFRA 21-1 levels were observed in 44% of Stages I and II (n = 18) and 72% of Stage III and IV (n = 69) patients with non-small cell lung cancer (P < 0.05). A significant inter-marker correlation was observed between CYFRA 21-1 and TPA (n = 103, r = 0.448, P < 0.0001). Twenty-one patients were monitored by CYFRA 21-1, and significantly different changes in progressive patients (P = 0.0058) and regressive patients (P = 0.016) were obtained. These results indicate that CYFRA 21-1 may be not only a sensitive tumour marker in the diagnosis of bronchogenic carcinoma, but also a useful marker for the monitoring of bronchogenic carcinoma. more...
- Full Text
- View/download PDF
14. Impact of cigarette smoking on the relationship between body mass index and coronary heart disease: a pooled analysis of 3264 stroke and 2706 CHD events in 378579 individuals in the Asia Pacific region
- Author
-
L. S. Liu, Z. M. Chen, Z. Tang, Y. He, Atsushi Hozawa, J. Lee, T. Hashimoto, Matthew Knuiman, Annette J. Dobson, Graham G. Giles, B. F. Zhou, Michael Hobbs, Anthony Rodgers, Robyn J. Broadhurst, Hiroshi Maegawa, X. H. Yu, J. Zhou, D. F. Gu, Sohel Reza Choudhury, Stephen MacMahon, Y. H. Li, C. Q. Jiang, B. Zhou, Akihiko Nozaki, I. S. Kim, G. L. Shan, H. Y. Zhang, Mark Woodward, Noriaki Aoki, S. Ameratunga, Hiroshi Horibe, Z. Hong, Tim Welborn, H. Tanaka, X. H. Fang, Z. Z. Li, Z. S. Wu, M. S. Huang, W. H. Pan, Rodney Jackson, X. F. Duan, Il Suh, Kei Nakachi, S. C. Ho, Y. Kita, X. G. Wu, Y. Imai, M. Nakamura, Rachel R. Huxley, Xianghua Fang, S. C. Li, Piyamitr Sritara, Hirotsugu Ueshima, S. H. Jee, Mieko Kagaya, S. X. Yao, Z. L. Wu, J. L. Fuh, D. Heng, Hisatomi Arima, T. Ohkubo, K. Hughes, Shigeyuki Saitoh, Robyn Norton, M. Iida, Kiyomi Sakata, Yutaka Kiyohara, S. K. Chew, Akiko Tamakoshi, L. Q. Chen, Jean Woo, J. X. Xie, T. Yamada, Mary A. Luszcz, H. Christensen, Konrad Jamrozik, Hyeon Chang Kim, Gillian Whitlock, Akira Okayama, Tai Hing Lam, Yasuko Matsutani, Q. D. Yang, N. Kubo, Paul Norman, C. H. Yao, and Kazuaki Shimamoto more...
- Subjects
Gerontology ,medicine.medical_specialty ,Asia ,medicine.medical_treatment ,Population ,Coronary Disease ,030204 cardiovascular system & hematology ,Overweight ,Body Mass Index ,Stroke - epidemiology - physiopathology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Weight loss ,Internal medicine ,Tobacco ,medicine ,Humans ,Coronary Disease - epidemiology - physiopathology ,030212 general & internal medicine ,cardiovascular diseases ,education ,Stroke ,Proportional Hazards Models ,2. Zero hunger ,education.field_of_study ,business.industry ,Smoking ,Weight change ,Public Health, Environmental and Occupational Health ,medicine.disease ,Confidence interval ,3. Good health ,Smoking cessation ,medicine.symptom ,business ,Body mass index ,Follow-Up Studies ,Research Article - Abstract
BACKGROUND: Elevated levels of body mass index (BMI) and smoking are well established lifestyle risk factors for coronary heart disease (CHD) and stroke. If these two risk factors have a synergistic relationship, rigorous lifestyle modification may contribute to greater reduction in cardiovascular burden than previously expected. METHODS: A pooled analysis of individual participant data from 38 cohorts, involving 378,579 participants. Hazards ratios (HRs) and 95% confidence intervals (CIs) for BMI by cigarette smoking status were estimated using Cox proportional hazard models. RESULTS: During a mean follow-up of 3.8 years, 2706 CHD and 3264 strokes were recorded. There was a log-linear, positive relationship of BMI with CHD and stroke in both smokers and non-smokers with evidence of a synergistic effect of smoking on the association between BMI and CHD only: HRs (95% CIs) associated with a 2 kg/m2 higher BMI were 1.13 (1.10-1.17) in current smokers and 1.09 (1.06-1.11) in non-smokers (p-value for interaction=0.04). CONCLUSION: Smoking amplifies the positive association between BMI and CHD but not stroke. If confirmed, these results suggest that effective strategies that target smoking cessation and weight loss are likely to have a greater impact than anticipated on reducing the burden of CHD., published_or_final_version more...
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.