1. Induction of micronucleated reticulocytes by potassium bromate and potassium chromate in CD-1 male mice
- Author
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T Kuwahara, Takumi Awogi, S. Asanami, K Murata, Takeshi Morita, K. Shimono, and M. Uejima
- Subjects
Male ,Erythrocytes ,Reticulocytes ,Potassium Compounds ,Mice, Inbred Strains ,Toxicology ,Mice ,chemistry.chemical_compound ,Reticulocyte ,Chromates ,Genetics ,medicine ,Animals ,Micronucleus Tests ,Dose-Response Relationship, Drug ,Bromates ,Acridine orange ,Molecular biology ,Dose–response relationship ,Supravital staining ,medicine.anatomical_structure ,chemistry ,Biochemistry ,Micronucleus test ,Bone marrow ,Potassium bromate ,Potassium chromate ,Mutagens - Abstract
Micronucleus tests of potassium bromate (KBrO3) and potassium chromate (K2CrO4) were conducted with peripheral blood reticulocytes (PB-RETs) of CD-1 male mice dose intraperitoneally. Peripheral blood cells collected from the tail were stained supravitally with acridine orange (AO) using AO-coated glass slides. Both KBrO3 and K2CrO4 induced micronuclei in PB-RETs in the same manner as in polychromatic erythrocytes of bone marrow.
- Published
- 1992
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