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1. Heat Incubation Inactivates Streptococcal Exotoxins and Recombinant Cholesterol-Dependent Cytolysins: Suilysin, Pneumolysin and Streptolysin O

Author

K. Ezoe and Tatsuya Nakayama

Subjects
Hot Temperature, Pneumolysin, Streptococcus suis, biology, Protein Stability, Toxin, Exotoxins, General Medicine, biology.organism_classification, medicine.disease_cause, Applied Microbiology and Biotechnology, Microbiology, Hemolysin Proteins, Cholesterol, Streptococcus pneumoniae, Bacterial Proteins, Streptolysins, medicine, Streptolysin, Thermolabile, Incubation, Exotoxin
Abstract

Streptococcus species release cholesterol-dependent cytolysins (CDCs), which are a main toxin, and their heat susceptibility is poorly understood. The aim of this study was to clarify the heat susceptibility of streptococcal exotoxins and CDCs. Streptococcal exotoxins were treated with heat incubation at 60 °C for 10 or 30 min. The Streptococcus suis exotoxin of serotypes 1 and 2 exhibited more than 50 % haemolytic activity, and all Streptococcus pneumoniae exotoxins exhibited more than 60 % haemolytic activity. During the thermolabile assay, the virulent streptococcal haemolytic activity remarkably decreased after being heated at 60 °C for 10 m. Then, streptococcal recombinant CDCs were produced and put through a thermolabile assay. The haemolytic activity of suilysin (SLY), pneumolysin (PLY) and streptolysin O (SLO) decreased more than 80 % after heat incubation. We also conducted a TER assay to evaluate the cell monolayer. The cell monolayer of all CDCs broke down, and the FITC-dextran translocated at 1 h post addition, while the CDCs treated with heating did not induce cell disruption. Moreover, the microscopy analysis demonstrated that CDCs treated with heating lost their activity. In conclusion, heat incubation induced the inactivation of streptococcal exotoxins and CDCs. Heat incubation plays a role in the degradation of the streptococcal exotoxin, and this result applies to the inhibition of streptococcal infection.

Published
2014

2. POSTER VIEWING SESSION - ENDOMETRIOSIS, ENDOMETRIUM, IMPLANTATION AND FALLOPIAN TUBE

Author

K. K. Palial, J. Drury, L. Heathcote, A. Valentijin, R. G. Farquharson, R. Gazvani, P. S. Rudland, D. K. Hapangama, N. Celik, O. Celik, E. Aktan, E. Ozerol, E. Celik, K. Bozkurt, H. Paran, S. Hascalik, I. Ozerol, T. Arase, T. Maruyama, H. Uchida, K. Miyazaki, H. Oda, S. Uchida-Nishikawa, M. Kagami, A. Yamazaki, K. Tamaki, Y. Yoshimura, M. De Vos, C. Ortega, J. Smitz, I. Van Vaerenbergh, C. Bourgain, P. Devroey, D. Luciano, C. Exacoustos, E. Zupi, A. A. Luciano, D. Arduini, W. A. Palomino, F. Argandona, P. Kohen, R. Azua, A. Scarella, L. Devoto, B. McKinnon, N. A. Bersinger, M. D. Mueller, M. Bonavita, M. Mattila, F. P. Ferreira, V. Maia-Filho, A. M. Rocha, P. Serafini, E. L. A. Motta, H. Kim, C. H. Kim, R. M. You, H. Y. Nah, J. W. Lee, H. J. Kang, B. M. Kang, H. Letur - Koenirsch, D. Haouzi, F. Olivennes, C. Rouleau, P. Cohen-Bacri, H. Dechaud, S. Hamamah, T. D'Hooghe, L. Hummelshoj, G. A. J. Dunselman, C. D. Dirksen, W. E. R. F. EndoCost Consortium, S. Simoens, R. Novembri, S. Luisi, P. Carrarelli, A. L. L. Rocha, P. Toti, F. M. Reis, P. Florio, F. Petraglia, K. D. Bruce, K. H. Sadek, N. Macklon, F. R. Cagampang, Y. Cheong, M. Goudakou, A. Kalogeraki, I. Matalliotakis, A. Papatheodorou, T. Pasadaki, A. Karkanaki, I. Prapas, I. Panagiotidis, E. Kasapi, D. Barlow, J. Oliver, E. Loumaye, M. Khanmohammadi, S. kazemnejad, S. darzi, S. Khanjani, A. Zarnani, M. Akhondi, C. W. Tan, C. P. Ng, S. F. Loh, H. H. Tan, M. Choolani, L. Griffith, J. Chan, K. L. Andersson, J. Sundqvist, G. Scarselli, K. Gemzell-Danielsson, P. G. Lalitkumar, S. Jana, R. Chattopadhyay, C. Datta Ray, K. Chaudhury, B. N. Chakravarty, N. Hannan, J. Evans, C. Hincks, L. J. F. Rombauts, L. A. Salamonsen, D. Choi, J. Lee, J. Park, H. Chang, M. Kim, K. Hwang, K. Takeuchi, T. Kurematsu, Y. Fukumoto, Y. Yuki, Y. Kuroki, Y. Homan, Y. Sata, M. Takeuchi, E. Munoz Munoz, G. Ortiz Olivera, I. Fernandez Lopez, B. Martinez Martinez, J. Aguilar Prieto, S. Portela Perez, A. Pellicer Martinez, M. Keltz, M. Sauerbrun, A. Breborowicz, E. Gonzales, S. Vicente-Munoz, L. Puchades-Carrasco, I. Morcillo, J. J. Hidalgo, J. Gilabert-Estelles, E. Novella-Maestre, A. Pellicer, A. Pineda-Lucena, K. A. Yavorovskaya, T. A. Okhtyrskaya, T. A. Demura, N. M. Faizulina, L. S. Ezhova, E. A. Kogan, J. P. Bilibio, C. A. B. Souza, G. P. Rodini, V. Genro, C. G. Andreoli, E. de Conto, J. S. L. Cunha-Filho, M. Saare, D. Soritsa, L. Jarva, K. Vaidla, P. Palta, M. Laan, H. Karro, A. Soritsa, A. Salumets, M. Peters, A. Miskova, M. Pilmane, D. Rezeberga, S. Assou, H. Letur, P. Piomboni, A. Stendardi, L. Gambera, V. De Leo, R. Focarelli, K. Tamm, J. Simm, M. Metsis, A. Vodolazkaia, A. Fassbender, C. M. Kyama, A. Bokor, D. Schols, D. Huskens, C. Meuleman, K. Peeraer, C. Tomassetti, T. M. D'Hooghe, K. Machens, W. Afhuppe, A. Schulz, K. Diefenbach, B. Schutt, T. Faustmann, J. Reischl, S. Altmae, J. Reimand, T. Laisk, O. Hovatta, R. Kolde, J. Vilo, A. Stavreus-Evers, J. H. Lee, S. G. Kim, Y. Y. Kim, I. H. Park, H. G. Sun, K. H. Lee, K. Ezoe, H. Kawano, A. Yabuuchi, K. Ochiai, H. Nagashima, H. Osada, N. Kagawa, O. Kato, I. Tamura, H. Asada, T. Taketani, H. Tamura, N. Sugino, J. Garcia Velasco, L. Prieto, J. F. Quesada, O. Cambero, M. Toribio, C. Y. Hur, K. S. Lim, W. D. Lee, J. H. Lim, A. Germeyer, L. Nelson, A. Graham, J. Jauckus, T. Strowitzki, B. Lessey, I. Gyulmamedova, O. Illina, I. Illin, I. Mogilevkina, A. Chaika, O. Nosenko, I. Boykova, E. Gulmamedova, H. Isik, O. Moraloglu, A. L. I. Seven, S. Kilic, U. Erkayiran, M. Caydere, S. Batioglu, M. Alhalabi, S. Samawi, A. Taha, N. Kafri, S. Modi, A. Khatib, J. Sharif, A. Othman, S. Lancuba, C. Branzini, M. Lopez, A. Baricalla, C. Cristina, J. Chen, Y. Jiang, X. Zhen, Y. Hu, G. Yan, H. Sun, J. Mizumoto, J. Ueno, F. M. Carvalho, G. Casals, J. Ordi, M. Guimera, M. Creus, F. Fabregues, R. Casamitjana, F. Carmona, J. Balasch, Y. S. Choi, K. C. Kim, K. H. Kim, B. S. Lee, S. H. Kim, L. Overbergh, E. Verdrengh, C. Kyama, E. Waelkens, C. Mathieu, T. Iwasa, K. Hatano, E. Hasegawa, H. Ito, K. Isaka, F. Reis, K. S. Lee, J. K. Joo, J. B. Son, J. R. Choi, A. Vidali, D. H. Barad, N. Gleicher, M. Sayyah-Melli, and M. Kazemi-Shishvan

Subjects
Gynecology, medicine.medical_specialty, business.industry, Obstetrics, Rehabilitation, Endometriosis, Obstetrics and Gynecology, Endometrium, medicine.disease, medicine.anatomical_structure, Reproductive Medicine, medicine, Session (computer science), business, Fallopian tube
Published
2011

3. The assessment of optimal timing of oocyte retrieval based on LH surge in natural cycle IVF: a large scale retrospective study

Author

Keiichi Kato, N. Yatabe, H. Yamasaki, Tamotsu Kobayashi, Kazunori Shinohara, K. Ezoe, D. Sato, Akiko Yabuuchi, M. Ito, and A. Yuge

Subjects
Gynecology, medicine.medical_specialty, medicine.anatomical_structure, Reproductive Medicine, Scale (ratio), business.industry, Natural cycle ivf, Emergency medicine, Obstetrics and Gynecology, Medicine, Retrospective cohort study, business, Oocyte
Published
2016

4. Tumor Necrosis Factor-α Increased the Integrin α2β1 Expression and Cell Attachment to Type I Collagen in Human Dermal Fibroblasts

Author

T. Horikoshi and K. Ezoe

Subjects
Integrins, Integrin, Biophysics, Biochemistry, Collagen receptor, Laminin, Cell Adhesion, medicine, Humans, Fibroblast, Molecular Biology, Cells, Cultured, Skin, biology, Tumor Necrosis Factor-alpha, Cell adhesion molecule, Antibodies, Monoclonal, Cell Biology, Fibroblasts, Fibronectins, Cell biology, Fibronectin, medicine.anatomical_structure, Immunology, biology.protein, Collagen, Wound healing, Type I collagen
Abstract

Cell adhesion molecules of human dermal fibroblasts play an important role in the processes of wound healing. The effects of tumor necrosis factor- alpha (TNF) on the expression of integrin beta 1 subfamily in human dermal fibroblasts were examined. TNF preferentially induced the expression of alpha 2 beta 1 integrins, receptors for collagen and laminin, in a time and dose dependent manner. Cell attachment to type I collagen increased by the treatment with TNF. However, cell attachment to fibronectin and laminin was not increased. This TNF-induced cell attachment could be reduced significantly by anti-integrin alpha 2 beta 1 antibody. Antibodies against receptors other than alpha 2 beta 1 integrin did not significantly reduce cell attachment. These data suggest that the increased attachment of human dermal fibroblasts to type I collagen appears to be mediated predominantly through the augmentation of integrin alpha 2 beta 1 expression by TNF.

Published
1993

5. Ovarian hyperstimulation using human chorionic gonadotropin impairs uterine receptivity by altering ovarian hormone levels and downstream signaling

Author

Tamotsu Kobayashi, Keiichi Kato, Akiko Yabuuchi, K. Ezoe, Takashi Okuno, and N. Murata

Subjects
medicine.medical_specialty, Endocrinology, Reproductive Medicine, business.industry, Internal medicine, Ovarian hyperstimulation, medicine, Obstetrics and Gynecology, Uterine receptivity, business, Ovarian hormone, Human chorionic gonadotropin
Published
2014

6. The ramification of the superficial branch of the superior gluteal artery. Anatomical basis of a new gluteus maximus myocutaneous flap

Author

K Ezoe, Y Takami, and M Y Kida

Subjects
Male, medicine.medical_specialty, Greater trochanter, Ramification (botany), Iliac crest, Surgical Flaps, Pathology and Forensic Medicine, Cadaver, Superior gluteal artery, medicine.artery, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Gluteus maximus muscle, Aged, Aged, 80 and over, business.industry, Fascia, Anatomy, Arteries, Middle Aged, musculoskeletal system, Surgery, body regions, medicine.anatomical_structure, Buttocks, Female, Deep fascia, business
Abstract

In order to design a new gluteus maximus myocutaneous flap, the ramification of the superficial branch of the superior gluteal artery was investigated in 56 sides of 33 Japanese cadavers. The superficial branch constantly divides into two main branches, which are called the ascending and transverse branches in this study. Of the ascending and transverse branches, one or both usually give off at least one well developed division running on the undersurface of the gluteus maximus muscle (98.2%). This division, which is called the intermediate branch in this study, generally reaches the superior edge of the muscle giving off only a couple of muscular branches and pierces the muscle and its deep fascia to supply skin (83.6%). Perforators of the intermediate branch constantly emerge from the fascia near the middle or lower one-third point on a line extending from the middle of the iliac crest to the tip of the greater trochanter.

Published
1992

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