Author: "Jihoon An" / Topic: medicine - Searchworks@Jio Institute Digital Library Search Results

1,135 results on '"Jihoon An"'

1. Association of short-term particulate matter exposure with suicide death among major depressive disorder patients: a time-stratified case-crossover analysis

Author: In Young Hwang, Daein Choi, Jihoon Andrew Kim, Seulggie Choi, Jooyoung Chang, Ae Jin Goo, Ahryoung Ko, Gyeongsil Lee, Kyae Hyung Kim, Joung Sik Son, and Sang Min Park
Subjects: Medicine, Science
Abstract: Abstract There is growing evidence that suggests a potential association between particulate matter (PM) and suicide. However, it is unclear that PM exposure and suicide death among major depressive disorder (MDD) patients, a high-risk group for suicide. We aimed to assess the effect of short-term exposure to PM on the risk of suicide in MDD patients who are at high risk for suicide. We investigated the risk of suicide among 922,062 newly-diagnosed MDD patients from 2004 to 2017 within the Korean National Health Insurance Service (NHIS) database. We identified 3,051 suicide cases from January 1, 2015, to December 31, 2017, within the death statistics database of the Korean National Statistical Office. PMs with aerodynamic diameter less than 2.5 μm (PM2.5), less than 10 μm (PM10), and 2.5–10 μm (PM2.5–10) were considered, which were provided from the National Ambient Air Monitoring System in South Korea. Time-stratified case-crossover analysis was performed to investigate the association of particulate matter exposure to suicide events. The risk of suicide was significantly high upon the high level of exposure to PM2.5, PM2.5–10 (coarse particle) and PM10 on lag 1 (p for trend
Published: 2022
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2. The conceptual building blocks of everyday thought: Tracking the emergence and dynamics of ruminative and nonruminative thinking

Author: Jessica R. Andrews-Hanna, Hedwig Eisenbarth, Elizabeth A. Reynolds Losin, Tor D. Wager, Byeol Kim, Ramsey Wilcox, Jihoon Han, and Choong-Wan Woo
Subjects: Adult, Experimental and Cognitive Psychology, PsycINFO, Article, Semantic network, Semantics, Task (project management), Developmental Neuroscience, Dynamics (music), Rumination, medicine, Humans, Tracking (education), medicine.symptom, Valence (psychology), Psychology, Free association (psychology), General Psychology, Cognitive psychology
Abstract: How do thoughts arise, unfold, and change over time? Are the contents and dynamics of everyday thought rooted in conceptual associations within one's semantic networks? To address these questions, we developed the Free Association Semantic task (FAST), whereby participants generate dynamic chains of conceptual associations in response to seed words that vary in valence. Ninety-four adults from a community sample completed the FAST task and additionally described and rated six of their most frequently occurring everyday thoughts. Text analysis and valence ratings revealed similarities in thematic and affective content between FAST concept chains and recurrent autobiographical thoughts. Dynamic analyses revealed that individuals higher in rumination were more strongly attracted to negative conceptual spaces and more likely to remain there longer. Overall, these findings provide quantitative evidence that conceptual associations may act as a semantic scaffold for more complex everyday thoughts, and that more negative and less dynamic conceptual associations in ruminative individuals mirror maladaptive repetitive thoughts in daily life. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Published: 2022
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3. sj-docx-1-wso-10.1177_17474930231168742 – Supplemental material for Dual antiplatelet Use for extended period taRgeted to AcuTe ischemic stroke with presumed atherosclerotic OrigiN (DURATION) trial: Rationale and design

Author: Kim, Joon-Tae, Kang, Jihoon, Kim, Beom Joon, Kim, Jun Yup, Han, Moon-Ku, Cho, Ki-Hyun, Park, Man-Seok, Choi, Kang-Ho, Park, Jong-Moo, Kang, Kyusik, Kim, Yong Soo, Lee, Soo Joo, Kim, Jae Guk, Cha, Jae-Kwan, Kim, Dae-Hyun, Park, Tai Hwan, Park, Sang-Soon, Choi, Jin Kyo, Lee, Kyungbok, Park, Kwang-Yeol, Jeong, Hae-Bong, Lee, Jun, Kwon, Doo Hyuk, Cho, Yong-Jin, Hong, Keun-Sik, Park, Hong-Kyun, Lee, Byung-Chul, Yu, Kyung-Ho, Oh, Mi Sun, Lee, Minwoo, Kim, Dong-Eog, Gwak, Dong-Seok, Choi, Jay Chol, Kim, Joong-Goo, Kang, Chul-Hoo, Kwon, Jee-Hyun, Kim, Wook-Joo, Shin, Dong-Ick, Yum, Kyu Sun, Sohn, Sung Il, Hong, Jeong-Ho, Park, Hyungjong, Kim, Chulho, Lee, Sang-Hwa, Lee, Juneyoung, Gorelick, Philip B, Norrving, Bo, and Bae, Hee-Joon
Subjects: FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract: Supplemental material, sj-docx-1-wso-10.1177_17474930231168742 for Dual antiplatelet Use for extended period taRgeted to AcuTe ischemic stroke with presumed atherosclerotic OrigiN (DURATION) trial: Rationale and design by Joon-Tae Kim, Jihoon Kang, Beom Joon Kim, Jun Yup Kim, Moon-Ku Han, Ki-Hyun Cho, Man-Seok Park, Kang-Ho Choi, Jong-Moo Park, Kyusik Kang, Yong Soo Kim, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Sang-Soon Park, Jin Kyo Choi, Kyungbok Lee, Kwang-Yeol Park, Hae-Bong Jeong, Jun Lee, Doo Hyuk Kwon, Yong-Jin Cho, Keun-Sik Hong, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Minwoo Lee, Dong-Eog Kim, Dong-Seok Gwak, Jay Chol Choi, Joong-Goo Kim, Chul-Hoo Kang, Jee-Hyun Kwon, Wook-Joo Kim, Dong-Ick Shin, Kyu Sun Yum, Sung Il Sohn, Jeong-Ho Hong, Hyungjong Park, Chulho Kim, Sang-Hwa Lee, Juneyoung Lee, Philip B Gorelick, Bo Norrving and Hee-Joon Bae in International Journal of Stroke
Published: 2023
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4. A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

Author: Tohru Ishitani, Yuki Shino, Alessandra Merenda, Juqi Zou, Hidehisa Takahashi, Tadasuke Tsukiyama, Takamasa Masuda, Shigetsugu Hatakeyama, Sayuri Terai, Keiichi I. Nakayama, Yusuke Ohba, Jihoon Kim, Shohei Ogamino, Masaki Matsumoto, Yoichiro Fujioka, Bon-Kyoung Koo, Tomonori Hirose, Tsukiyama, Tadasuke [0000-0001-5205-8202], Kim, Jihoon [0000-0002-3258-6953], Ogamino, Shohei [0000-0001-7562-3753], Matsumoto, Masaki [0000-0002-6987-0288], Hirose, Tomonori [0000-0003-2428-0919], Ishitani, Tohru [0000-0002-6200-7043], Nakayama, Keiichi I. [0000-0002-7185-1529], Ohba, Yusuke [0000-0003-2461-8289], Koo, Bon-Kyoung [0000-0002-4134-8033], Apollo - University of Cambridge Repository, and Nakayama, Keiichi I [0000-0002-7185-1529]
Subjects: 0301 basic medicine, Frizzled, Carcinogenesis, Mutant, General Physics and Astronomy, medicine.disease_cause, Mice, 0302 clinical medicine, 692/4028/67/70, Phosphorylation, Tumour-suppressor proteins, lcsh:Science, Zebrafish, Cancer genetics, Wnt Signaling Pathway, Mutation, Mice, Inbred BALB C, Multidisciplinary, biology, Wnt signaling pathway, article, 3. Good health, Ubiquitin ligase, Cell biology, 030220 oncology & carcinogenesis, 631/67/1244, 631/80/86/2368, 64/60, Ubiquitin-Protein Ligases, Science, macromolecular substances, Oncogene Protein p21(ras), General Biochemistry, Genetics and Molecular Biology, 631/80/474/2073, 03 medical and health sciences, medicine, Animals, Humans, Cancer models, 64/116, Growth factor signalling, General Chemistry, biology.organism_classification, 96/100, 030104 developmental biology, 692/4028/67/68, Ubiquitin ligases, Proteolysis, 13/95, biology.protein, lcsh:Q, Receptors, Wnt, Tumor Suppressor Protein p53
Abstract: Frequent mutation of the tumour suppressor RNF43 is observed in many cancers, particularly colon malignancies. RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity requires phosphorylation at a triplet of conserved serines. This phospho-regulation of RNF43 is required for zebrafish development and growth of mouse intestinal organoids. Cancer-associated mutations that abrogate RNF43 phosphorylation cooperate with active Ras to promote tumorigenesis by abolishing the inhibitory function of RNF43 in Wnt signalling while maintaining its inhibitory function in p53 signalling. Our data suggest that RNF43 mutations cooperate with KRAS mutations to promote multi-step tumorigenesis via the Wnt-Ras-p53 axis in human colon cancers. Lastly, phosphomimetic substitutions of the serine trio restored the tumour suppressive activity of extracellular oncogenic mutants. Therefore, harnessing phospho-regulation of RNF43 might be a potential therapeutic strategy for tumours with RNF43 mutations., RNF43 is frequently mutated in cancers and negatively regulates Wnt signalling. Here, the authors report that RNF43 phosphorylation at a serine triplet is required for the negative regulation of Wnt signalling and that the phosphorylation of RNF43 suppresses cancer-associated oncogenic RNF43 mutants.
Published: 2020

5. Smoking Methylation Marks for Prediction of Urothelial Cancer Risk

Author: Damien M Bolton, Theodore M. Brasky, Maree Brinkman, Melissa C. Southey, Julie K. Bassett, Roger L. Milne, Ee Ming Wong, Jihoon E. Joo, Parveen Bhatti, Aladdin H. Shadyab, Chenglong Yu, Dallas R. English, Pierre Antoine Dugué, Kristina M. Jordahl, Graham G. Giles, John L. Hopper, Enes Makalic, Lesley Tinker, Daniel F. Schmidt, and Anthony Longano
Subjects: Oncology, medicine.medical_specialty, education.field_of_study, Epidemiology, business.industry, Population, Confounding, Area under the curve, Odds ratio, Methylation, Internal medicine, Cohort, DNA methylation, medicine, education, business, Cohort study
Abstract: Background: Self-reported information may not accurately capture smoking exposure. We aimed to evaluate whether smoking-associated DNA methylation markers improve urothelial cell carcinoma (UCC) risk prediction. Methods: Conditional logistic regression was used to assess associations between blood-based methylation and UCC risk using two matched case–control samples: 404 pairs from the Melbourne Collaborative Cohort Study (MCCS) and 440 pairs from the Women's Health Initiative (WHI) cohort. Results were pooled using fixed-effects meta-analysis. We developed methylation-based predictors of UCC and evaluated their prediction accuracy on two replication data sets using the area under the curve (AUC). Results: The meta-analysis identified associations (P < 4.7 × 10−5) for 29 of 1,061 smoking-associated methylation sites, but these were substantially attenuated after adjustment for self-reported smoking. Nominally significant associations (P < 0.05) were found for 387 (36%) and 86 (8%) of smoking-associated markers without/with adjustment for self-reported smoking, respectively, with same direction of association as with smoking for 387 (100%) and 79 (92%) markers. A Lasso-based predictor was associated with UCC risk in one replication data set in MCCS [N = 134; odds ratio per SD (OR) = 1.37; 95% CI, 1.00–1.90] after confounder adjustment; AUC = 0.66, compared with AUC = 0.64 without methylation information. Limited evidence of replication was found in the second testing data set in WHI (N = 440; OR = 1.09; 95% CI, 0.91–1.30). Conclusions: Combination of smoking-associated methylation marks may provide some improvement to UCC risk prediction. Our findings need further evaluation using larger data sets. Impact: DNA methylation may be associated with UCC risk beyond traditional smoking assessment and could contribute to some improvements in stratification of UCC risk in the general population.
Published: 2021
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6. Overview of Legal Measures for Managing Workplace COVID-19 Infection Risk in Several Asia-Pacific Countries

Author: Miller Derek, Mila Tejamaya, Dong-Uk Park, Marina Zainal Farid, Feng Jen Tsai, Alex Reginald, Ruey Yu Chen, Jihoon Park, Chantana Padungtod, Wantanee Phanprasit, Nelia Granadillos, Go Muto, Jiwon Kim, Carmela Q. Capule, Chungsik Yoon, Kyong Hui Lee, Yu Wen Lin, Haruo Hashimoto, Jeongim Park, and Vilandi Putri
Subjects: Economic growth, medicine.medical_specialty, infectious disease risk, media_common.quotation_subject, Legislation, paid sick leave, Administration (probate law), Occupational hygiene, ANOH(Asian Network of Occupational Hygiene), medicine, Safety, Risk, Reliability and Quality, Personal protective equipment, media_common, Chemical Health and Safety, Public health, Corporate governance, Public Health, Environmental and Occupational Health, COVID-19, personal protective equipment, Sick leave, Original Article, Business, Public aspects of medicine, RA1-1270, Safety Research, Welfare
Abstract: Background Despite the lack of official COVID-19 statistics, various workplaces and occupations have been at the center of COVID-19 outbreaks. We aimed to compare legal measures and governance established for managing COVID-19 infection risks at workplaces in nine Asia and Pacific countries and to recommend key administrative measures. Methods We collected information on legal measures and governance from both general citizens and workers regarding infection risks such as COVID-19 from industrial hygiene professionals in nine countries (Indonesia, India, Japan, Malaysia, New Zealand, Republic of the Philippines, Republic of Korea, Taiwan, and Thailand) using a structured questionnaire. Results A governmental body overseeing public health and welfare was in charge of containing the spread and occurrence of infectious diseases under an infectious disease control and prevention act or another special act, although the name of the pertinent organizations and legislation vary among countries. Unlike in the case of other traditional hazards, there have been no specific articles or clauses describing the means of mitigating virus risk in the workplace that are legally required of employers, making it difficult to define the responsibilities of the employer. Each country maintains own legal systems regarding access to the duration, administration, and financing of paid sick leave. Many workers may not have access to paid sick leave even if it is legally guaranteed. Conclusion Specific legal measures to manage infectious disease risks, such as providing proper personal protective equipment, education, engineering control measures, and paid sick leave are recommended to be stipulated in Industrial safety and health-related acts.
Published: 2021
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7. Rare germline variants in the AXIN2 gene in families with colonic polyposis and colorectal cancer

Author: Rebecca Purvis, Daniel D. Buchanan, James M Chan, Ryan Hutchinson, Andrew J. Metz, Jihoon E. Joo, Romy Walker, Nathan Atkinson, Sharelle Joseland, Julia Como, Ingrid Winship, Galina Konycheva, Mark Clendenning, Mark A. Jenkins, Christophe Rosty, Varnika Vijay, Bernard J. Pope, Peter Georgeson, Catherine Beard, Finlay A. Macrae, Susan Parry, Julie Arnold, Susan Preston, and Khalid Mahmood
Subjects: Proband, Cancer Research, Ectodermal dysplasia, Colorectal cancer, business.industry, medicine.disease, digestive system diseases, Germline, Frameshift mutation, Loss of heterozygosity, Oncology, Genetics, Cancer research, medicine, AXIN2, business, Genetics (clinical), Exome sequencing
Abstract: Germline loss-of-function variants in AXIN2 are associated with oligodontia and ectodermal dysplasia. The association between colorectal cancer (CRC) and colonic polyposis is less clear despite this gene now being included in multi-gene panels for CRC. Study participants were people with genetically unexplained colonic polyposis recruited to the Genetics of Colonic Polyposis Study who had a rare germline AXIN2 gene variant identified from either clinical multi-gene panel testing (n=2) or from whole genome/exome sequencing (n=2). Variant segregation in relatives and characterisation of tumour tissue were performed where possible. Four different germline pathogenic variants in AXIN2 were identified in four families. Five of the seven carriers of the c.1049delC, p.Pro350Leufs*13 variant, two of the six carriers of the c.1994dupG, p.Asn666Glnfs*41 variant, all three carriers of c.1972delA, p.Ser658Alafs*31 variant and the single proband carrier of the c.2405G>C, p.Arg802Thr variant, which creates an alternate splice form resulting in a frameshift mutation (p.Glu763Ilefs*42), were affected by CRC and/or polyposis. Carriers had a mean age at diagnosis of CRC/polyposis of 52.5 ± 9.2 years. Colonic polyps were typically pan colonic with counts ranging from 5 to >100 (median 12.5) comprising predominantly adenomatous polyps but also serrated polyps. Two CRCs from carriers displayed evidence of a second hit via loss of heterozygosity. Oligodontia was observed in carriers from two families. Germline AXIN2 pathogenic variants from four families were associated with CRC and/or polyposis in multiple family members. These findings support the inclusion of AXIN2 in CRC and polyposis multigene panels for clinical testing.
Published: 2021
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8. Comparative effects of different manual techniques on electromyography activity, kinematics, and muscle force in limited ankle dorsiflexion syndrome

Author: Chanhee Park, Youngjoo Cha, Joshua Sung H You, and Jihoon Lee
Subjects: Adult, medicine.medical_specialty, Posture, Physical Therapy, Sports Therapy and Rehabilitation, Kinematics, Electromyography, Static stretching, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, medicine, Humans, Orthopedics and Sports Medicine, Range of Motion, Articular, Muscle, Skeletal, Balance (ability), 030222 orthopedics, medicine.diagnostic_test, business.industry, Rehabilitation, Soft tissue, 030229 sport sciences, Biomechanical Phenomena, Cross-Sectional Studies, medicine.anatomical_structure, Squatting position, Ankle, Range of motion, business, Ankle Joint
Abstract: BACKGROUND: Although the instrument-assisted manual (IM) technique has been widely utilised to improve soft tissue and joint mobility, its therapeutic benefits and underlying neuromechanical mechanisms remain unknown compared to those of conventional static stretching (SS) and hold-relax (HR) manual techniques. OBJECTIVE: This study aimed to compare the effects of the SS, HR, and IM techniques on muscle activity, kinematics, and strength during deep squatting in limited ankle dorsiflexion (DF) syndrome. METHODS: This was a cross-sectional randomised controlled study including 39 adults divided into three groups: SS group: 13, HR group: 13, IM group: 13. Outcome measures were the tibialis anterior (TA): gastrocnemius (GCM) balance ratio and ankle, knee, hip and thoracolumbar junction angles. TA muscle strength was analysed to evaluate the limited ankle DF. Analysis of variance was performed, with P< 0.05. RESULTS: The TA:GCM balance ratio, ranges of motion of ankle DF and knee flexion, and TA muscle strength in the IM group improved significantly compared to that in either the SS group or HR group (P< 0.05). CONCLUSIONS: Our novel results demonstrated that IM was most effective in normalising TA:GCM balance, ankle DF range of motion, and TA muscle strength during deep squatting in adults with limited ankle DF.
Published: 2021
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9. Single center experience of inferior vena cava filter retrieval in trauma patients: contrast-enhanced CT-based retrieval within hospital stay

Author: Jihoon Hong, Kyoung Hoon Lim, Seung Ick Cha, Jung Guen Cha, Jaehee Lee, Sang Yub Lee, Chang Ho Kim, Chang Wug Oh, Miran Kim, and Hyung-Kee Kim
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, media_common.quotation_subject, Inferior vena cava filter, Computed tomography, equipment and supplies, Single Center, Inferior vena cava, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine.vein, 030220 oncology & carcinogenesis, medicine, Contrast (vision), Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Radiology, business, Active filter, Hospital stay, Venous thromboembolism, media_common
Abstract: Purpose To assess the safety and retrieval rate of a predischarge inferior vena cava (IVC) filter retrieval strategy based on contrast computed tomography (CT). Methods IVC filter insertion for trauma patients from 2010 to 2018 were reviewed. An active filter retrieval strategy was established in March 2017. The strategy sought early evaluation of venous thromboembolism (VTE) status and filter retrieval before a patient's discharge. The possibility of early IVC filter retrieval was evaluated by a multidisciplinary team based on pre-filter retrieval VTE-CT findings. Overall VTE-CT findings, retrieval rate, indwelling time, and recurrence of venous thromboembolic events were compared before and after the filter retrieval strategy setup. Results 177 IVC filters were inserted in trauma patients. All patients underwent pre-filter retrieval VTE-CT. VTE-CT findings were as follows: completely resolved VTE, n = 108 (61%); partially improved, n = 58 (33%); no change, n = 8 (5%); aggravated, n = 3 (2%). The overall retrieval rate was 84% with a mean indwelling time of 32 days. In subgroup analyses, 95 (53%) had filter retrieval with the before strategy (BS) setup and 82 (47%) with the after strategy (AS) setup. The retrieval rate was significantly higher in the AS group [81/82 (99%) vs. 68/95 (72%), (p Conclusions The active strategy of VTE-CT-based filter retrieval during the hospital stay markedly improved the filter retrieval rate from 72% to 99% without evidence of recurrence of VTE. Hazards of low retrieval rate versus CT-related radiation exposure should be studied in the future.
Published: 2021
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10. Prognosis of Myocardial Injury After Non-Cardiac Surgery in Adults Aged Younger Than 45 Years

Author: Kyunga Kim, Sang-Chol Lee, Joonghyun Ahn, Ji-Hye Kwon, Jin-Ho Choi, Jong-Hwan Lee, Jeong Jin Min, Jungchan Park, Seung-Hwa Lee, Ah Ran Oh, Kwangmo Yang, Jihoon Kim, and Hyeon-Cheol Gwon
Subjects: Adult, medicine.medical_specialty, 030204 cardiovascular system & hematology, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Risk Factors, Internal medicine, Humans, Medicine, In patient, 030304 developmental biology, Cardiovascular mortality, 0303 health sciences, biology, business.industry, Hazard ratio, General Medicine, Perioperative, Odds ratio, Middle Aged, Prognosis, Troponin, Confidence interval, Heart Injuries, Non cardiac surgery, biology.protein, Cardiology and Cardiovascular Medicine, business
Abstract: This study compared myocardial injury after non-cardiac surgery (MINS) and mortalities between patients under and over the age of 45 years.Methods and Results:From January 2010 and June 2019, patients with cardiac troponin measurement within 30 days after non-cardiac surgery were enrolled and divided into groups according to age:45 (≥45 years) and45 (45 years). Further analyses were conducted only in patients who were diagnosed with MINS. The outcomes were MINS and 30-day mortality. Of the 35,223 patients, 31,161 (88.5%) patients were in the45-year group and 4,062 (11.5%) were in the45-year group. After adjustment with inverse probability of weighting, the45-years group showed a lower incidence of MINS and cardiovascular mortality (16.6% vs. 11.7%; odds ratio, 0.77; 95% confidence interval [CI], 0.69-0.84; P0.001 and 0.4% vs. 0.2%; hazard ratio [HR], 0.41; 95% CI, 0.19-0.88; P=0.02, respectively). In a comparison of only the45-years group, MINS was associated with increased 30-day mortality (0.7% vs. 10.3%; HR, 10.48; 95% CI, 6.18-17.78; P0.001), but the mortalities of patients with MINS did not differ according to age.MINS has a comparable prognostic impact in patients aged under and over 45 years; therefore, future studies need to also consider patients aged45 years regarding risk factors of MINS and screening of perioperative troponin elevation.
Published: 2021
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11. Unraveling the Genomic Architecture of the CYP3A Locus and ADME Genes for Personalized Tacrolimus Dosing

Author: Sang Il Min, Sanghoon Moon, Jae Berm Park, In-Jin Jang, Hyo Kee Kim, Ho Sik Shin, Seung Hwan Song, Sungkyoung Choi, Young-Jin Kim, Jihoon G. Yoon, Yuri Cho, Myoung Soo Kim, Min Goo Lee, Hye Eun Yoon, Bong-Jo Kim, Jaeseong Oh, Jongwon Ha, Jaeseok Yang, and Chul Woo Yang
Subjects: Adult, Graft Rejection, Male, Oncology, medicine.medical_specialty, Adolescent, Pharmacogenomic Variants, Clinical Decision-Making, Locus (genetics), Genome-wide association study, Risk Assessment, Tacrolimus, Young Adult, Pharmacokinetics, Predictive Value of Tests, Risk Factors, Internal medicine, Republic of Korea, medicine, Cytochrome P-450 CYP3A, Humans, Precision Medicine, CYP3A5, Aged, Retrospective Studies, ADME, Aged, 80 and over, Transplantation, business.industry, Graft Survival, Haplotype, Confounding, Middle Aged, Kidney Transplantation, Pharmacogenomic Testing, Cross-Sectional Studies, Treatment Outcome, Haplotypes, Pharmacogenetics, Female, business, Immunosuppressive Agents, Genome-Wide Association Study
Abstract: Background Tacrolimus (TAC) is an immunosuppressant widely prescribed following an allogenic organ transplant. Due to wide interindividual pharmacokinetic (PK) variability, optimizing TAC dosing based on genetic factors is required to minimize nephrotoxicity and acute rejections. Methods We enrolled 1133 participants receiving TAC from 4 cohorts, consisting of 3 with kidney transplant recipients and 1 with healthy males from clinical trials. The effects of clinical factors were estimated to appropriately control confounding variables. A genome-wide association study (GWAS), haplotype analysis, and a gene-based association test were conducted using the Korea Biobank Array or targeted sequencing for 114 pharmacogenes. Results GWAS verified that CYP3A5*3 is the only common variant associated with TAC PK variability in Koreans. We detected several CYP3A5 and CYP3A4 rare variants which could potentially affect TAC metabolism. The haplotype structure of CYP3A5 stratified by CYP3A5*3 was a significant factor for CYP3A5 rare variant interpretation. CYP3A4 rare variant carriers among CYP3A5 intermediate metabolizers displayed higher TAC trough levels. Gene-based association tests in the 61 absorption, distribution, metabolism, and excretion (ADME) genes revealed that CYP1A1 are associated with additional TAC PK variability: CYP1A1 rare variant carriers among CYP3A5 poor metabolizers showed lower TAC trough levels than the noncarrier controls. Conclusions Our study demonstrates that rare variant profiling of CYP3A5 and CYP3A4, combined with the haplotype structures of CYP3A locus, provide additive value for personalized TAC dosing. We also identified a novel association between CYP1A1 rare variants and TAC PK variability in the CYP3A5 nonexpressers which needs to be further investigated.Supplemental Visual Abstract; http://links.lww.com/TP/C134.
Published: 2021
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12. A Deep Learning Model with High Standalone Performance for Diagnosis of Unruptured Intracranial Aneurysm

Author: Beomseok Sohn, Sang Min Lee, Seung Koo Lee, Kyunghwa Han, Hwa Pyung Kim, Tae Gyu Kim, Jihoon Cha, So Yeon Won, Jong Mun Choi, Bio Joo, Hyun Seok Choi, Sung Soo Ahn, and Hwi Young Kim
Subjects: medicine.medical_specialty, Artificial intelligence, medicine.diagnostic_test, business.industry, Deep learning, magnetic resonance angiography, Intracranial Aneurysm, General Medicine, medicine.disease, Confidence interval, Magnetic resonance angiography, Radiology, Medical Imaging, Clinical trial, Aneurysm, Deep Learning, Sample size determination, medicine, Humans, Christian ministry, Original Article, Radiology, Detection rate, business, Retrospective Studies
Abstract: Purpose This study aimed to investigate whether a deep learning model for automated detection of unruptured intracranial aneurysms on time-of-flight (TOF) magnetic resonance angiography (MRA) can achieve a target diagnostic performance comparable to that of human radiologists for approval from the Korean Ministry of Food and Drug Safety as an artificial intelligence-applied software. Materials and methods In this single-center, retrospective, confirmatory clinical trial, the diagnostic performance of the model was evaluated in a predetermined test set. After sample size estimation, the test set consisted of 135 aneurysm-containing examinations with 168 intracranial aneurysms and 197 aneurysm-free examinations. The target sensitivity and specificity were set as 87% and 92%, respectively. The patient-wise sensitivity and specificity of the model were analyzed. Moreover, the lesion-wise sensitivity and false-positive detection rate per case were also investigated. Results The sensitivity and specificity of the model were 91.11% [95% confidence interval (CI): 84.99, 95.32] and 93.91% (95% CI: 89.60, 96.81), respectively, which met the target performance values. The lesion-wise sensitivity was 92.26%. The overall false-positive detection rate per case was 0.123. Of the 168 aneurysms, 13 aneurysms from 12 examinations were missed by the model. Conclusion The present deep learning model for automated detection of unruptured intracranial aneurysms on TOF MRA achieved the target diagnostic performance comparable to that of human radiologists. With high standalone performance, this model may be useful for accurate and efficient diagnosis of intracranial aneurysm.
Published: 2021

13. Repeatability of methylation measures using a QIAseq targeted methyl panel and comparison with the Illumina HumanMethylation450 assay

Author: Fleur Hammet, Mahnaz Hosseinpour, Pierre Antoine Dugué, Ee Ming Wong, Melissa C. Southey, Tu Nguyen-Dumont, Graham G. Giles, James G. Dowty, Chenglong Yu, Jihoon E. Joo, John L. Hopper, and Robert J. MacInnis
Subjects: Oncology, medicine.medical_specialty, Science (General), Formalin-fixed paraffin-embedded, Intraclass correlation, QH301-705.5, Targeted bisulphite sequencing, Biology, Illumina Infinium methylation arrays, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Q1-390, Internal medicine, medicine, Bland–Altman plot, Biology (General), Intraclass correlation coefficient, Oligonucleotide Array Sequence Analysis, Paraffin Embedding, DNA methylation, High-Throughput Nucleotide Sequencing, General Medicine, Repeatability, Methylation, Genomics, Confidence interval, Whole blood, Research Note, chemistry, Medicine, High molecular weight dna, DNA
Abstract: Objective In previous studies using Illumina Infinium methylation arrays, we have identified DNA methylation marks associated with cancer predisposition and progression. In the present study, we have sought to find appropriate technology to both technically validate our data and expand our understanding of DNA methylation in these genomic regions. Here, we aimed to assess the repeatability of methylation measures made using QIAseq targeted methyl panel and to compare them with those obtained from the Illumina HumanMethylation450 (HM450K) assay. We included in the analysis high molecular weight DNA extracted from whole blood (WB) and DNA extracted from formalin-fixed paraffin-embedded tissues (FFPE). Results The repeatability of QIAseq-methylation measures was assessed at 40 CpGs, using the Intraclass Correlation Coefficient (ICC). The mean ICCs and 95% confidence intervals (CI) were 0.72 (0.62–0.81), 0.59 (0.47–0.71) and 0.80 (0.73–0.88) for WB, FFPE and both sample types combined, respectively. For technical replicates measured using QIAseq and HM450K, the mean ICCs (95% CI) were 0.53 (0.39–0.68), 0.43 (0.31–0.56) and 0.70 (0.59–0.80), respectively. Bland–Altman plots indicated good agreement between QIAseq and HM450K measurements. These results demonstrate that the QIAseq targeted methyl panel produces reliable and reproducible methylation measurements across the 40 CpGs that were examined.
Published: 2021

14. Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19

Author: Jihoon Shin, Michio Otsuki, Atsunori Fukuhara, Shigeki Nishitani, Iichiro Shimomura, Shunbun Kita, and Shinichiro Toyoda
Subjects: medicine.medical_specialty, Aging, Endocrinology, Diabetes and Metabolism, Calorie restriction, Adipose tissue, Adrenergic beta-3 Receptor Agonists, Cell Line, Mice, Internal medicine, Diabetes mellitus, Hyperinsulinism, Internal Medicine, Hyperinsulinemia, medicine, Diabetes Mellitus, Animals, Humans, Hypoglycemic Agents, Obesity, Receptor, Transcription factor, Endoplasmic Reticulum Chaperone BiP, Sodium-Glucose Transporter 2 Inhibitors, Aged, business.industry, SARS-CoV-2, COVID-19, Virus Internalization, medicine.disease, Metformin, Up-Regulation, Endocrinology, Adipose Tissue, Spike Glycoprotein, Coronavirus, Perspectives in Diabetes, Angiotensin-Converting Enzyme 2, business, medicine.drug
Abstract: Aging, obesity, and diabetes are major risk factors for the severe progression and outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019 [COVID-19]), but the underlying mechanism is not yet fully understood. In this study, we found that the SARS-CoV-2 spike protein physically interacts with cell surface GRP78, which promotes the binding to and accumulation in ACE2-expressing cells. GRP78 was highly expressed in adipose tissue and increased in humans and mice with older age, obesity, and diabetes. The overexpression of GRP78 was attributed to hyperinsulinemia in adipocytes, which was in part mediated by the stress-responsive transcription factor XBP-1s. Management of hyperinsulinemia by pharmacological approaches, including metformin, sodium–glucose cotransporter 2 inhibitor, or β3-adrenergic receptor agonist, decreased GRP78 gene expression in adipose tissue. Environmental interventions, including exercise, calorie restriction, fasting, or cold exposure, reduced the gene expression of GRP78 in adipose tissue. This study provides scientific evidence for the role of GRP78 as a binding partner of the SARS-CoV-2 spike protein and ACE2, which might be related to the severe progression and outcome of COVID-19 in patients with older age, obesity, and diabetes. The management of hyperinsulinemia and the related GRP78 expression could be a therapeutic or preventative target.
Published: 2021

15. Opportunistic Screening of Patients for Hepatic Steatosis: Clinical Follow-Up and Diagnostic Yield

Author: Jihoon Lim, David L. Coy, Rubal Penna, C. Craig Blackmore, and Barbara Williams
Subjects: Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, business.industry, Medical record, Fatty liver, Alcoholic hepatitis, medicine.disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, 030220 oncology & carcinogenesis, Internal medicine, Nonalcoholic fatty liver disease, medicine, Humans, Radiology, Nuclear Medicine and imaging, Clinical significance, Steatosis, business, Follow-Up Studies, Retrospective Studies, Ultrasonography
Abstract: Purpose Hepatic steatosis is a common incidental finding on abdominal imaging that is not always reported or recognized as having clinical significance. Because of its association with liver disease, cirrhosis, and diabetes, the aim of this study was to bring attention to this finding and provide clinical guidance to referring clinicians by inserting standardized text into radiology reports of patients with incidentally detected hepatic steatosis. Methods Patients with incidentally discovered hepatic steatosis on abdominal ultrasound or CT had standard text inserted into the impression sections of their diagnostic imaging reports. A total of 1,256 patients whose reports were tagged between April 2016 and September 2017 were retrospectively identified and their electronic medical records reviewed to determine subsequent acknowledgment in the medical record or clinical action in response to the tagged report. Information regarding patient demographics, the type of provider who ordered the examination, and the acuity of the examination results was also recorded. Results Acknowledgment and subsequent clinical action were more likely in patients whose examinations was ordered by primary care providers, whose examination results were not urgent, and who were in the ultrasound group. The overall diagnostic yield in patients who underwent clinical evaluation was nonalcoholic fatty liver disease in 70%, nonalcoholic steatohepatitis in 6%, and alcoholic hepatitis in 17%. Conclusions Opportunistic screening for incidental hepatic steatosis on abdominal CT and ultrasound is feasible, with substantial yield for patients with clinically important entities including nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Published: 2021
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16. Size-Related Differences in Computed Tomography Markers of Hematoma Expansion in Acute Intracerebral Hemorrhage

Author: Han-Gil Jeong, Hee-Yun Chae, Moon-Ku Han, Si-Un Lee, Jae Seung Bang, Jihoon Kang, Hee-Joon Bae, Yong Soo Kim, Beom Joon Kim, Chang Wan Oh, and Tac Keun Kim
Subjects: Intracerebral hemorrhage, medicine.medical_specialty, Receiver operating characteristic, business.industry, Odds ratio, Critical Care and Intensive Care Medicine, medicine.disease, Logistic regression, Confidence interval, body regions, surgical procedures, operative, Hematoma, Hounsfield scale, cardiovascular system, medicine, cardiovascular diseases, Neurology (clinical), Neurosurgery, Nuclear medicine, business
Abstract: Background Noncontrast computed tomography (NCCT) markers for hematoma expansion (HE) in intracerebral hemorrhage (ICH) are difficult to be found in small ICHs, of which can also expand. We aimed to investigate whether there were size-related differences in the prevalence of NCCT markers and their association with HE. Methods This retrospective analysis of prospectively collected stroke registry included 267 consecutive patients with ICH who underwent baseline NCCT within 12 h of onset. Qualitative NCCT markers, including heterogeneous density and irregular shape, were assessed. Hematoma density, defined as mean Hounsfield unit of hematoma, and hematoma volume were measured by semiautomated planimetry. Hematoma volume was categorized as small (≤ 10 ml) and large (> 10 ml). Associations of NCCT markers with HE were analyzed using multivariable logistic regression analyses. The model performances of NCCT markers and hematoma density were compared using receiver operating characteristic curves. Results Hematoma expansion occurred in 29.9% of small ICHs and 35.5% of large ICHs. Qualitative NCCT markers were less frequently observed in small ICHs. Heterogeneous density, irregular shape, and hematoma density were associated with HE in small ICH (adjusted odds ratios [95% confidence interval] 3.94 [1.50-10.81], 4.23 [1.73-10.81], and 0.72 [0.60-0.84], respectively), and hematoma density was also related to HE in large ICH (0.84 [0.73-0.97). The model performance was significantly improved in small ICHs when hematoma density was added to the baseline model (DeLong's test, p = 0.02). Conclusions The prevalence of NCCT markers and their association with HE differed according to hematoma volume. Quantitative hematoma density was associated with HE, regardless of hematoma size.
Published: 2021
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17. Reducing tumor invasiveness by ramucirumab and TGF‐β receptor kinase inhibitor in a diffuse‐type gastric cancer patient‐derived cell model

Author: Jung Yong Hong, Noo Li Jeon, Inkyoung Lee, Se Hoon Park, Seonggyu Byeon, Sujin Hyung, Jihoon Ko, Jeeyun Lee, Seung Tae Kim, and Song-Yi Lee
Subjects: Cancer Research, Epithelial-Mesenchymal Transition, ramucirumab, Angiogenesis, Antibodies, Monoclonal, Humanized, Ramucirumab, angiogenesis, Stomach Neoplasms, Cell Line, Tumor, medicine, Humans, Radiology, Nuclear Medicine and imaging, epithelial–mesenchymal transition (EMT), Receptor, Research Articles, RC254-282, Cancer Biology, Kinase, Chemistry, gastric cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cancer, medicine.disease, medicine.anatomical_structure, Oncology, Cell culture, embryonic structures, Cancer research, Receptors, Transforming Growth Factor beta, Research Article, Transforming growth factor, Blood vessel
Abstract: Background Diffuse‐type gastric cancer (GC) is known to be more aggressive and relatively resistant to conventional chemotherapy. Hence, more optimized treatment strategy is urgently needed in diffuse‐type GC. Methods Using a panel of 10 GC cell lines and 3 GC patient‐derived cells (PDCs), we identified cell lines with high EMTness which is a distinct feature for diffuse‐type GC. We treated GC cells with high EMTness with ramucirumab alone, TGF‐β receptor kinase inhibitor (TEW‐7197) alone, or in combination to investigate the drug's effects on invasiveness, spheroid formation, EMT marker expression, and tumor‐induced angiogenesis using a spheroid‐on‐a‐chip model. Results Both TEW‐7197 and ramucirumab treatments profoundly decreased invasiveness of EMT‐high cell lines and PDCs. With a 3D tumor spheroid‐on‐a‐chip, we identified versatile influence of co‐treatment on cancer cell‐induced blood vessel formation as well as on EMT progression in tumor spheroids. The 3D tumor spheroid‐on‐a‐chip demonstrated that TEW‐7197 + ramucirumab combination significantly decreased PDC‐induced vessel formation. Conclusions In this study, we showed TEW‐7197 and ramucirumab considerably decreased invasiveness, thus EMTness in a panel of diffuse‐type GC cell lines including GC PDCs. Taken together, we confirmed that combination of TEW‐7197 and ramucirumab reduced tumor spheroid and GC PDC‐induced blood vessel formation concomitantly in the spheroid‐on‐a‐chip model., Diffuse‐type gastric cancer (GC) is known to be more aggressive and relatively resistant to conventional chemotherapy. In this study, we sought a drug candidate for this type of cancer treatment and confirmed that combination of TEW‐7197 and ramucirumab reduced tumor spheroid invasiveness and GC PDC‐induced blood vessel formation concomitantly in the spheroid‐on‐a‐chip model.
Published: 2021
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18. Long-term Clinical and Hemodynamic Outcomes of Edge-to-Edge Repair for Tricuspid Regurgitation

Author: Sam Sae Oh, Jihoon Kim, Jae Suk Yoo, and Heemoon Lee
Subjects: Pulmonary and Respiratory Medicine, Mitral valve repair, medicine.medical_specialty, Tricuspid valve, business.industry, medicine.medical_treatment, Mitral valve replacement, Tricuspid stenosis, Regurgitation (circulation), medicine.disease, Surgery, Aortic cross-clamp, medicine.anatomical_structure, Aortic valve replacement, Mitral valve, cardiovascular system, medicine, cardiovascular diseases, Cardiology and Cardiovascular Medicine, business
Abstract: Background The edge-to-edge technique (Alfieri stitch) has been widely adopted in mitral valve but not tricuspid valve (TV) repair. We evaluated long-term clinical and hemodynamic outcomes of tricuspid edge-to-edge repair. Methods We retrospectively reviewed 237 patients (mean age, 58.4 ± 13.9 years) who had undergone tricuspid edge-to-edge repair from January 2001 to March 2019 in our institution. Tricuspid annuloplasty was performed in 175 patients (73.8%) using ring (91 [38.4%]) or suture (84 [35.4%]) annuloplasty. Concomitant procedures were mitral valve replacement (133 [56.1%]), mitral valve repair (52 [21.9%]), aortic valve replacement (41 [17.3%]), and maze operation (138 [58.2%]). Results Postoperative echocardiography revealed mild or less tricuspid regurgitation (TR) in 220 patients (92.8%). Early mortality ( Conclusions Tricuspid edge-to-edge repair showed acceptable long-term clinical and hemodynamic results and is an effective and safe option in TV surgery.
Published: 2021
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19. Optimal strategy for side branch treatment in patients with left main coronary bifurcation lesions

Author: Myung Ho Jeong, June-Hong Kim, Jae-Hwan Lee, Hyo-Soo Kim, Jong-Seon Park, Seung-Hyuk Choi, Jihoon Kim, Dong Woon Jeon, Ki Bae Seung, Taek Kyu Park, Seung Ho Hur, Seung Hwan Lee, Joo Myung Lee, Young Bin Song, Jin-Ho Choi, Ju Hyeon Oh, Sang Yeub Lee, Seung-Woon Rha, Woo-Jung Park, Joo-Yong Hahn, Sung Yun Lee, Hyeon-Cheol Gwon, Rak Kyeong Choi, and Jeong Hoon Yang
Subjects: Target lesion, medicine.medical_specialty, business.industry, Coronary Artery Disease, General Medicine, 030204 cardiovascular system & hematology, Coronary Angiography, medicine.disease, Surgery, 03 medical and health sciences, Dissection, Percutaneous Coronary Intervention, Treatment Outcome, 0302 clinical medicine, Main vessel, Multicenter trial, Side branch, medicine, Humans, In patient, Prospective Studies, Myocardial infarction, Angioplasty, Balloon, Coronary, business, Coronary bifurcation
Abstract: Introduction and objectives There are no guidelines regarding the most appropriate approach for provisional side branch (SB) intervention in left main (LM) bifurcation lesions. Methods The present prospective, randomized, open-label, multicenter trial compared conservative vs aggressive strategies for provisional SB intervention during LM bifurcation treatment. Although the trial was designed to enroll 700 patients, it was prematurely terminated due to slow enrollment. For 160 non-true bifurcation lesions, a 1-stent technique without kissing balloon inflation was applied in the conservative strategy, whereas a 1-stent technique with mandatory kissing balloon inflation was applied in the aggressive strategy. For 46 true bifurcation lesions, a stepwise approach was applied in the conservative strategy (after main vessel stenting, SB ballooning when residual stenosis > 75%; then, SB stenting if residual stenosis > 50% or there was a dissection). An elective 2-stent technique was applied in the aggressive strategy. The primary outcome was a 1-year target lesion failure (TLF) composite of cardiac death, myocardial infarction, or target lesion revascularization . Results Among non-true bifurcation lesions, the conservative strategy group used a smaller amount of contrast dye than the aggressive strategy group. There were no significant differences in 1-year TLF between the 2 strategies among non-true bifurcation lesions (6.5% vs 4.9%; HR, 1.31; 95%CI, 0.35-4.88; P = .687) and true bifurcation lesions (17.6% vs 21.7%; HR, 0.76; 95%CI, 0.20-2.83; P = .683). Conclusions In patients with a LM bifurcation lesion, conservative and aggressive strategies for a provisional SB approach have similar 1-year TLF rates.
Published: 2021
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20. Mediation effects of mean Hounsfield unit on relationship between hemoglobin and expansion of intracerebral hemorrhage

Author: Moon Ku Han, Han-Gil Jeong, Chang Wan Oh, Jihoon Kang, Jun Yup Kim, Tackeun Kim, Hee-Joon Bae, Jae Seung Bang, Yong Soo Kim, Hee Yun Chae, and Beom Joon Kim
Subjects: Male, medicine.medical_specialty, Mediation (statistics), Science, Article, Hemoglobins, Hematoma, Hounsfield scale, Internal medicine, Odds Ratio, medicine, Humans, cardiovascular diseases, Aged, Cerebral Hemorrhage, Aged, 80 and over, Intracerebral hemorrhage, Mediation Analysis, Multidisciplinary, business.industry, Confounding, Brain, Odds ratio, Middle Aged, medicine.disease, Stroke, Hemostasis, Multivariate Analysis, Cardiology, Regression Analysis, Medicine, Female, Hemoglobin, Tomography, X-Ray Computed, business
Abstract: Low hemoglobin levels are known to be associated with hematoma expansion (HE) and poor functional outcome in patients with intracerebral hemorrhage (ICH). However, it is not yet known whether low hemoglobin itself causes HE directly or is merely a confounder. Thus, we investigated the mediation effect of the mean Hounsfield unit (HU) of hematoma on the relationship between low hemoglobin and expansion of ICH. Overall, 232 consecutive patients with ICH who underwent non-contrast computed tomography (NCCT) within 12 h since onset were included. The mean HU and hematoma volume on NCCT were investigated using semi-automated planimetry. HE was defined as an increase in hematoma volume > 33% or 6 mL. The respective associations among the hemoglobin level, mean HU, and HE were analyzed using multivariable regression analysis, adjusting for age, sex, and known HE predictors. Mediation analysis was performed to examine the potential causal association among the three. HE occurred in 34.5% of patients; hemoglobin levels were inversely associated with HE occurrence (adjusted odds ratio, 0.90; p = 0.03). The mean HU of the hematoma was lower in patients with HE than in patients without HE (58.5 ± 3.3 vs. 56.8 ± 3.0; p p p = 0.04). The proportion of indirect effect through the mean HU among the total effect was 19% (p = 0.05). The mediation effect became nonsignificant in the when the multivariable model was adjusted with additional covariates (baseline systolic blood pressure and hematoma location). The mean HU of the hematoma mediated the association between hemoglobin levels and HE occurrence. Therefore, the mean HU of the hematoma may be a potential marker of impaired hemostasis in patients with ICH.
Published: 2021

21. Molecular Characterization of Biliary Tract Cancer Predicts Chemotherapy and Programmed Death 1/Programmed Death‐Ligand 1 Blockade Responses

Author: Hoguen Kim, Jihoon G. Yoon, Mi Jang, Young Nyun Park, Chang Moo Kang, Min Goo Lee, Beodeul Kang, Hyun Cheol Chung, Choong-kun Lee, Min Hwan Kim, Woo Jung Lee, Hye Jin Choi, and Ho Kyoung Hwang
Subjects: Adult, Male, Ampulla of Vater, medicine.medical_treatment, Common Bile Duct Neoplasms, Programmed Cell Death 1 Receptor, Antineoplastic Agents, medicine.disease_cause, B7-H1 Antigen, Bile duct cancer, Cholangiocarcinoma, Proto-Oncogene Proteins p21(ras), Lymphocytes, Tumor-Infiltrating, Bile Ducts, Extrahepatic, Tumor Microenvironment, medicine, Humans, Immune Checkpoint Inhibitors, Intrahepatic Cholangiocarcinoma, Aged, Smad4 Protein, Aged, 80 and over, Tumor microenvironment, Chemotherapy, Massive parallel sequencing, Hepatology, Tumor-infiltrating lymphocytes, business.industry, Tumor Suppressor Proteins, Carcinoma, Immunotherapy, Middle Aged, medicine.disease, Isocitrate Dehydrogenase, Bile Ducts, Intrahepatic, Biliary Tract Neoplasms, Treatment Outcome, Bile Duct Neoplasms, Cancer research, Female, Gallbladder Neoplasms, KRAS, business, Ubiquitin Thiolesterase
Abstract: BACKGROUND AND AIMS Biliary tract cancer (BTC) exhibits diverse molecular characteristics. However, reliable biomarkers that predict therapeutic responses are yet to be discovered. We aimed to identify the molecular features of treatment responses to chemotherapy and immunotherapy in BTCs. APPROACH AND RESULTS We enrolled 121 advanced BTC patients (68 cholangiocarcinomas [33 intrahepatic, 35 extrahepatic], 41 gallbladder cancers, and 12 Ampulla of Vater cancers) whose specimens were analyzed by clinical sequencing platforms. All patients received first-line palliative chemotherapy; 48 patients underwent programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade therapy after failed chemotherapy. Molecular and histopathological characterization was performed using targeted sequencing and immunohistochemical staining to investigate treatment response-associated biomarkers. Genomic analysis revealed a broad spectrum of mutational profiles according to anatomical location. Favorable responses to chemotherapy were observed in the small-duct type compared with the large-duct type intrahepatic cholangiocarcinoma, with frequent mutations in BRCA1-associated protein-1/isocitrate dehydrogenase 1/2 and KRAS proto-oncogene, GTPase/SMAD family member 4 genes, respectively. The molecular features were further analyzed in BTCs, and transforming growth factor beta and DNA damage response pathway-altered tumors exhibited poor and favorable chemotherapy responses, respectively. In PD-1/PD-L1 blockade-treated patients, KRAS alteration and chromosomal instability tumors were associated with resistance to immunotherapy. The majority of patients (95.0%) with these resistance factors show no clinical benefit to PD-1/PD-L1 blockade and low tumor mutational burdens. Low tumor-infiltrating lymphocyte (TIL) density in tumors with these resistance factors indicated immune-suppressive tumor microenvironments, whereas high intratumoral TIL density was associated with a favorable immunotherapy response. CONCLUSIONS This study proposes predictive molecular features of chemotherapy and immunotherapy responses in advanced BTCs using clinical sequencing platforms. Our result provides an intuitive framework to guide the treatment of advanced BTCs benefiting from therapeutic agents based on the tumors' molecular features.
Published: 2021
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22. Clinical Value of Magnetic Resonance Spectroscopy in the Initial Evaluation of Patients with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes

Author: Jihoon Na, Je Hee Shin, Hyun Joo Lee, and Young Mock Lee
Subjects: Mitochondrial encephalomyopathy, medicine.medical_specialty, Neurosciences. Biological psychiatry. Neuropsychiatry, MELAS syndrome, acidosis, lactic, Internal medicine, medicine, mitochondrial encephalomyopathies, RC346-429, Mitochondrial Encephalomyopathies, mitochondrial diseases, business.industry, melas syndrome, Nuclear magnetic resonance spectroscopy, medicine.disease, magnetic resonance spectroscopy, RC31-1245, Neurology, Stroke like episodes, nervous system, Lactic acidosis, Pediatrics, Perinatology and Child Health, Cardiology, Clinical value, Neurology (clinical), Neurology. Diseases of the nervous system, business, RC321-571
Abstract: Purpose Magnetic resonance spectroscopy (MRS) is a diagnostic tool used to detect abnormal accumulation of lactate in the brain parenchyma in various metabolic diseases. This study evaluated the clinical roles of brain MRS in the initial assessment of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) caused by impairment of the mitochondrial respiratory chain. Methods Twenty-five patients with the A3243G mutation among 34 MELAS patients referred to the pediatric neurology clinic of Gangnam Severance Hospital between January 2006 and December 2020 were included. In this retrospective study, demographic, clinical, laboratory (serum lactate and lactate-to-pyruvate ratio), magnetic resonance imaging (MRI), and initial MRS (presence of lactate peak and abnormal N-acetylaspartate [NAA]) data were reviewed. Results Brain MRI showed cortical lesions in 24 of 25 genetically confirmed A3243G MELAS patients with neurologic symptoms in this study. On MRS, 18 patients (72%) had increased lactate peaks, depicting anaerobic energy metabolism, and 17 patients (68%) had decreased NAA levels, indicating neuronal integrity. Ten patients underwent MRS in the acute stage (within 2 weeks of symptoms). Unlike patients who underwent MRS more than 2 weeks after symptom onset, a lactate peak on MRS was observed in all patients in the acute stage (P=0.011). Conclusion Elevated lactate peaks in acute cerebral infarctions are highly suggestive of mitochondrial encephalopathy. MRS alone is insufficient to diagnose MELAS, but it is valuable as a noninvasive supplemental diagnostic tool in combination with genetic testing.
Published: 2021

23. Predictive Analytics for Glaucoma Using Data From the All of Us Research Program

Author: Francis Ratsimbazafy, Andrea H. Ramirez, Jihoon Kim, Kelly A. Gebo, Sally L. Baxter, Eric Boerwinkle, Roxana Loperena, Luca Bonomi, Stephen Mockrin, Sheri D. Schully, Cheryl R. Clark, Lucila Ohno-Machado, Elizabeth Cohn, Bharanidharan Radha Saseendrakumar, Mine S. Cicek, Tsung-Ting Kuo, Paulina Paul, and Kelsey R. Mayo
Subjects: Male, Databases, Factual, Computer science, Information Storage and Retrieval, Glaucoma, Logistic regression, Article, Standard deviation, Machine Learning, Statistics, medicine, Electronic Health Records, Humans, Aged, Aged, 80 and over, Models, Statistical, Receiver operating characteristic, Artificial neural network, Middle Aged, Predictive analytics, medicine.disease, Random forest, Ophthalmology, Logistic Models, ROC Curve, Filtering Surgery, Cohort, Female, Neural Networks, Computer, Glaucoma, Open-Angle
Abstract: PURPOSE: To (1) use All of Us (AoU) data to validate a previously published single-center model predicting need for surgery among individuals with glaucoma, (2) train new models using AoU data, and (3) share insights regarding this novel data source for ophthalmic research. DESIGN: Development and evaluation of machine learning models. METHODS: Electronic health record data were extracted from AoU for 1231 adults diagnosed with primary open-angle glaucoma. The single-center model was applied to AoU data for external validation. AoU data were then used to train new models for predicting need for glaucoma surgery using multivariable logistic regression, artificial neural networks, and random forests. Five-fold cross-validation was performed. Model performance was evaluated based on area under the receiver operating characteristic curve (AUC), accuracy, precision and recall. RESULTS: The mean (standard deviation) age of the All of Us cohort was 69.1 (10.5) years, with 57.3% women and 33.5% Black, significantly exceeding representation in the single-center cohort (p=0.04 and p
Published: 2021
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24. Unilateral and Reversible Hypoglossal Nerve Palsy Due to Infectious Mononucleosis

Author: Ji Hyen Lee and Jihoon Na
Subjects: Hypoglossal Nerve Palsy, Mononucleosis, business.industry, Neurosciences. Biological psychiatry. Neuropsychiatry, medicine.disease, RC31-1245, Neurology, Anesthesia, Pediatrics, Perinatology and Child Health, medicine, Neurology (clinical), Neurology. Diseases of the nervous system, business, RC346-429, Internal medicine, RC321-571
Published: 2022

25. Efficacy and safety of intraglandular botulinum toxin injections for treatment of sialadenosis

Author: Jae Yol Lim, Seung Jin Lee, Jihoon Choi, Yu Tae Jeon, Geun Cheol Shin, and Min Pyo Hong
Subjects: Adult, Male, Sialadenitis, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Botulinum Toxins, Type A, 030223 otorhinolaryngology, Prospective cohort study, Retrospective Studies, Salivary gland, business.industry, Facial weakness, Cosmesis, Middle Aged, Dry mouth, medicine.disease, Botulinum toxin, Facial paralysis, Parotid gland, medicine.anatomical_structure, Neuromuscular Agents, Otorhinolaryngology, 030220 oncology & carcinogenesis, Anesthesia, Female, medicine.symptom, business, medicine.drug
Abstract: Objectives We aimed to evaluate the safety and efficacy of botulinum toxin type A (BoNTA) injections for the treatment of sialadenosis. Methods We retrospectively reviewed 20 patients treated with intraglandular BoNTA injections. Patient satisfaction was assessed using Likert scales: a three-point scale to evaluate improvement in the sense of parotid distention and a five-point scale to assess improvement in cosmesis. Complications, such as salivary dysfunction and facial weakness, were monitored during follow-up after injections. Results Patients received a median of two injections (range, one to five injections) of BoNTA (40-50 U/mL per injection) into each parotid gland. Three months after treatment, five (25%), 11 (55%), and four (20%) patients experienced complete, partial, and no relief of salivary gland distention with discomfort, respectively. For esthetic scoring, two (10%), five (25%), 10 (50%), three (15%), and no patients were assigned scores of 3, 2, 1, 0, and -1, respectively. Salivary gland scintigraphy was performed for 14 patients before injection. Ten and four patients showed normal and increased uptake by the salivary glands, respectively. At 3 months after injection, salivary gland scintigraphy showed that maximum salivary secretions significantly decreased, whereas salivary flow did not significantly differ between pre- and post-injection. No patient complained of dry mouth or facial weakness during follow-up. Conclusions Intraglandular BoNTA injections might be an alternative option for treating symptomatic sialadenosis, although it is only partially effective for alleviating parotidomegaly and often requires repeated injections. Long-term prospective studies are needed to optimize the dosage and treatment intervals of BoNTA injection.
Published: 2021
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26. Privacy-protecting, reliable response data discovery using COVID-19 patient observations

Author: Douglas S. Bell, Jason N. Doctor, Xiaoqian Jiang, Lisa M. Schilling, Michael Aratow, Mark J. Pletcher, Hua Xu, Kai Zheng, Paulina Paul, Larissa Neumann, Jihoon Kim, Ludwig Christian Hinske, Daniella Meeker, Katherine K. Kim, Spencer L. SooHoo, Michele E. Day, Michael E. Matheny, and Lucila Ohno-Machado
Subjects: Male, Multivariate statistics, AcademicSubjects/SCI01060, Hospitalized patients, Computer science, Ethnic group, Information Storage and Retrieval, Logistic regression, Medical and Health Sciences, 01 natural sciences, regression analysis, Engineering, 0302 clinical medicine, Medicine, Electronic Health Records, Registries, 030212 general & internal medicine, Common Data Elements, Clinical course, Regression analysis, electronic health record, Distributed algorithm, Female, Confidentiality, Algorithms, Natural language, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), MEDLINE, Health Informatics, Research and Applications, Health outcomes, Article, Computer Communication Networks, 03 medical and health sciences, Information and Computing Sciences, Humans, ddc:610, 0101 mathematics, AcademicSubjects/MED00580, Natural Language Processing, Descriptive statistics, business.industry, 010102 general mathematics, COVID-19, Data discovery, Data science, Good Health and Well Being, Logistic Models, R2D2 Consortium, Emergency medicine, observational study, Observational study, Generic health relevance, AcademicSubjects/SCI01530, business, Medical Informatics
Abstract: Objective To utilize, in an individual and institutional privacy-preserving manner, electronic health record (EHR) data from 202 hospitals by analyzing answers to COVID-19-related questions and posting these answers online. Materials and Methods We developed a distributed, federated network of 12 health systems that harmonized their EHRs and submitted aggregate answers to consortia questions posted at https://www.covid19questions.org. Our consortium developed processes and implemented distributed algorithms to produce answers to a variety of questions. We were able to generate counts, descriptive statistics, and build a multivariate, iterative regression model without centralizing individual-level data. Results Our public website contains answers to various clinical questions, a web form for users to ask questions in natural language, and a list of items that are currently pending responses. The results show, for example, that patients who were taking angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, within the year before admission, had lower unadjusted in-hospital mortality rates. We also showed that, when adjusted for, age, sex, and ethnicity were not significantly associated with mortality. We demonstrated that it is possible to answer questions about COVID-19 using EHR data from systems that have different policies and must follow various regulations, without moving data out of their health systems. Discussion and Conclusions We present an alternative or a complement to centralized COVID-19 registries of EHR data. We can use multivariate distributed logistic regression on observations recorded in the process of care to generate results without transferring individual-level data outside the health systems.
Published: 2021
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27. 2020 Korean guidelines for the management of metastatic prostate cancer

Author: Joo Han Lim, Chi Hoon Maeng, Inkeun Park, Sang Joon Shin, Joo Young Jung, Young Seok Kim, Jae Young Joung, Byeong Seok Sohn, Se Hoon Park, Seungtaek Lim, Inho Kim, Yoon Ji Choi, Woo Kyun Bae, Chan Kyu Kim, Dalyong Kim, Hee Jun Kim, Miso Kim, Jae-Lyun Lee, Jaeho Cho, Jin Young Kim, Byung Woog Kang, Hyun Chang, Min Young Lee, Jung Lim Lee, Kwonoh Park, Jihoon Kang, and Hyo Jin Lee
Subjects: Oncology, Male, medicine.medical_specialty, prostate neoplasms, Management guideline, Review, Castration resistant, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Internal medicine, Republic of Korea, Medicine, Humans, Clinical efficacy, business.industry, practice guideline, Prostatic Neoplasms, Evidence-based medicine, Guideline, medicine.disease, Hormone sensitive prostate cancer, 030211 gastroenterology & hepatology, Prostate neoplasm, business
Abstract: In 2017, Korean Society of Medical Oncology (KSMO) published the Korean man agement guideline of metastatic prostate cancer. This paper is the 2nd edition of the Korean management guideline of metastatic prostate cancer. We updated recent many changes of management in metastatic prostate cancer in this 2nd edition guideline. The present guideline consists of the three categories: man agement of metastatic hormone sensitive prostate cancer; management of meta static castration resistant prostate cancer; and clinical consideration for treating patients with metastatic prostate cancer. In category 1 and 2, levels of evidence (LEs) have been mentioned according to the general principles of evidence-based medicine. And grades of recommendation (GR) was taken into account the qual ity of evidence, the balance between desirable and undesirable effects, the values and preferences, and the use of resources and GR were divided into strong rec ommendations (SR) and weak recommendations (WR). A total of 16 key questions are selected. And we proposed recommendations and described key evidence for each recommendation. The treatment landscape of metastatic prostate cancer is changing very rapid and many trials are ongoing. To verify the results of the fu ture trials is necessary and should be applied to the treatment for metastatic prostate cancer patients in the clini cal practice. Especially, many prostate cancer patients are old age, have multiple underlying medical comorbidities, clinicians should be aware of the significance of medical management as well as clinical efficacy of systemic treat ment.
Published: 2021

28. Prevalence and clinical impact of vitamin D deficiency in critically ill Korean patients with traumatic injuries: a single-center, prospective, observational study

Author: Lim, Kyoung Hoon, Jang, Jihoon, and Park, Jinyoung
Subjects: Mechanical ventilation, medicine.medical_specialty, business.industry, RC86-88.9, Mortality rate, medicine.medical_treatment, Poison control, vitamin d, Medical emergencies. Critical care. Intensive care. First aid, deficiency, Critical Care and Intensive Care Medicine, Critical Care Nursing, medicine.disease, Single Center, vitamin D deficiency, trauma, Internal medicine, Anesthesiology, medicine, Vitamin D and neurology, Original Article, business, Cohort study
Abstract: Background This study investigated the prevalence and impact of 25-hydroxyvitamin D (25(OH) vitamin D) deficiency in critically ill Korean patients with traumatic injuries. Methods This prospective observational cohort study assessed the 25(OH) vitamin D status of consecutive trauma patients admitted to the trauma intensive care unit (TICU) of Kyungpook National University Hospital between January and December 2018. We analyzed the prevalence of 25(OH) vitamin D deficiency and its impact on clinical outcomes. Results There were no significant differences in the duration of mechanical ventilation (MV), lengths of TICU and hospital stays, and rates of nosocomial infection and mortality between patients with 25(OH) vitamin D
Published: 2021

29. Feasibility of fetal left modified myocardial performance index in twin anemia polycythemia sequence and perinatal outcomes after antenatal intervention

Author: Ba-Da Jeong, Rina Kim, Mi-Young Lee, Hye-Sung Won, Alharbi Usamah, and Jihoon Lee
Subjects: medicine.medical_specialty, Polycythemia, 030204 cardiovascular system & hematology, Twin-to-twin transfusion syndrome, Ultrasonography, Prenatal, 03 medical and health sciences, Monochorionic Diamniotic Twin Pregnancy, Fetus, 0302 clinical medicine, Pregnancy, hemic and lymphatic diseases, Intervention (counseling), medicine, Humans, Twin Anemia-Polycythemia Sequence, Myocardial Performance Index, Retrospective Studies, 030219 obstetrics & reproductive medicine, business.industry, Obstetrics, Infant, Obstetrics and Gynecology, Anemia, Fetofetal Transfusion, Twins, Monozygotic, medicine.disease, Pediatrics, Perinatology and Child Health, Pregnancy, Twin, Clinical value, Feasibility Studies, Female, Doppler ultrasound, business
Abstract: To evaluate the feasibility and clinical value of fetal left modified myocardial performance index (Mod-MPI) in assessment and management of prenatal twin anemia polycythemia sequence (TAPS).We retrospectively reviewed fetuses with TAPS diagnosed prenatally between 2015 and 2019 at Asan Medical Center. Doppler ultrasound evaluation including the peak systolic velocity (PSV) of the middle cerebral artery (MCA) and fetal echocardiography including left Mod-MPI were evaluated and followed up after antenatal management.Among 10 cases of fetal twin pregnancies with prenatal TAPS, six were spontaneous and four were post-laser TAPS. Left Mod-MPI was abnormal in one or both twins of nine cases (90%) including all post-laser TAPS (Fetal left Mod-MPI was useful for assessment of compromised fetal cardiac function in cases with prenatal TAPS. Application of fetal left Mod-MPI in prenatal staging of TAPS might help evaluate the severity of TAPS and decide timely antenatal intervention.
Published: 2021
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30. Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition

Author: Ming Wang, Jihoon Jo, Gwangho Yoon, and Juhyun Song
Subjects: 0301 basic medicine, endocrine system, Dendritic spine, Science, Long-Term Potentiation, Type 2 diabetes, Hippocampal formation, Biology, Molecular neuroscience, Diet, High-Fat, Neuroprotection, Hippocampus, Article, Synaptic plasticity, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Mice, 0302 clinical medicine, Insulin resistance, Cognition, medicine, Animals, Obesity, Cells, Cultured, Cerebral Cortex, Neurons, Spine regulation and structure, Multidisciplinary, Neuronal Plasticity, digestive, oral, and skin physiology, Long-term potentiation, Dendrites, medicine.disease, 030104 developmental biology, Neuronal physiology, Exenatide, Medicine, Metabolic syndrome, Insulin Resistance, Neuroscience, 030217 neurology & neurosurgery, hormones, hormone substitutes, and hormone antagonists
Abstract: Metabolic syndrome, which increases the risk of obesity and type 2 diabetes has emerged as a significant issue worldwide. Recent studies have highlighted the relationship between metabolic imbalance and neurological pathologies such as memory loss. Glucagon-like peptide 1 (GLP-1) secreted from gut L-cells and specific brain nuclei plays multiple roles including regulation of insulin sensitivity, inflammation and synaptic plasticity. Although GLP-1 and GLP-1 receptor agonists appear to have neuroprotective function, the specific mechanism of their action in brain remains unclear. We investigated whether exendin-4, as a GLP-1RA, improves cognitive function and brain insulin resistance in metabolic-imbalanced mice fed a high-fat diet. Considering the result of electrophysiological experiments, exendin-4 inhibits the reduction of long term potentiation (LTP) in high fat diet mouse brain. Further, we identified the neuroprotective effect of exendin-4 in primary cultured hippocampal and cortical neurons in in vitro metabolic imbalanced condition. Our results showed the improvement of IRS-1 phosphorylation, neuronal complexity, and the mature of dendritic spine shape by exendin-4 treatment in metabolic imbalanced in vitro condition. Here, we provides significant evidences on the effect of exendin-4 on synaptic plasticity, long-term potentiation, and neural structure. We suggest that GLP-1 is important to treat neuropathology caused by metabolic syndrome.
Published: 2021

31. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author: Henry Ma, Eleni Sakka, Hugues Chabriat, Duncan Wilson, Appu Suman, Peter J. Kelly, SL Ho, Charlotte Zerna, Eric Jouvent, Lawrence K.S. Wong, Anthea Parry, Frances Harrington, Jan Stam, Christopher Patterson, Rustam Al-Shahi Salman, Shigeru Inamura, Krishna A Dani, Henry Houlden, Sebastian Thilemann, Kotaro Iida, Chao Xu, Eunbin Ko, Daniel Guisado-Alonso, Urs Fischer, Caroline E. Lovelock, Man Yu Tse, Wing Chi Fong, Azlisham Mohd Nor, Clare Shakeshaft, Philippe Maeder, Henrik Gensicke, Stefan T. Engelter, James Okwera, Christopher Chen, Dulka Manawadu, John F. Corrigan, Efrat Kliper, Shelagh B. Coutts, Alexander P. Leff, Kam Tat Leung, Chathuri Yatawara, Leopold Hertzberger, M. Eline Kooi, Kazuhisa Yoshifuji, Hing Lung Ip, Keon-Joo Lee, Sanjeevikumar Meenakishundaram, Hiroyuki Irie, Marc Randall, Hatice Ozkan, Hideo Hara, Jill Abrigo, Raquel Delgado-Mederos, Shaloo Singhal, Enrico Flossmann, Beatriz Gómez-Ansón, Paul O'Mahony, Carmen Barbato, Ahamad Hassan, Francesca M Chappell, Harald Proschel, Vincent Mok, Masashi Nishihara, Lakshmanan Sekaran, Derya Selcuk Demirelli, Chu Peng Hoi, Hakan Ay, Joan Martí-Fàbregas, Rebeca Marín, Anne Cristine Guevarra, Martin Cooper, Einor Ben Assayag, Anne-Marie Mendyk, Christine Roffe, Myung Suk Jang, Maarten van Gemert, Hannah Cohen, Jae-Sung Lim, YK Wong, Bonnie Y.K. Lam, Janet Putterill, Wouter Schoonewille, Nick S. Ward, Nikola Sprigg, Kui Kai Lau, Bernard Esisi, Peter M. Rothwell, Henk Verbiest, Kirsty Harkness, Elisa Merino, Gareth Ambler, Arumug Nallasivam, Nigel Smyth, Paul A. Armitage, Heinrich Mattle, Pol Camps-Renom, Martin M. Brown, David Cohen, Min Lou, Pankaj Sharma, Sarah Gunkel, Elles Douven, Andreas Charidimou, Djamil Vahidassr, Cathy Soufan, Alexandros A Polymeris, Michael G. Hennerici, Chris Moran, Rachel Marsh, Mahmud Sajid, Kyohei Fujita, David J. Werring, Joanna M. Wardlaw, Derek Hayden, Joseph Kwan, Timothy J. England, Jaap van der Sande, Luis Prats-Sánchez, Paul Guyler, Ryan Hoi Kit Cheung, Koon-Ho Chan, Frank-Erik de Leeuw, Simone Browning, Jon Scott, Adrian Barry, Alejandro Martínez-Domeño, Luc Bracoub, Dinesh Chadha, Ijaz Anwar, Deborah Kelly, Moon-Ku Han, Anil M. Tuladhar, Thomas Gattringer, Fiona Carty, Abduelbaset Elmarim, Syed Mansoor, Enrico Flossman, Dilek Necioglu Orken, Jane Sword, Velandai Srikanth, Ping Wing Ng, Thomas W. Leung, Richard Shek-kwan Chang, Hans Rolf Jäger, Marwan El-Koussy, Jeroen Hendrikse, Khaled Darawil, Kazunori Toyoda, Mathuri Prabhakaran, Karim Mahawish, Ethem Murat Arsava, Jihoon Kang, Kwok Kui Wong, Michael Power, Felix Fluri, Enas Lawrence, Maam Mamun, Sissi Ispoglou, Mathew Burn, Siu Hung Li, Henry K.F. Mak, Kaori Miwa, Els De Schryver, Franz Fazekas, Jonathan G. Best, Louise Shaw, Hen Hallevi, Keith W. Muir, Ilse Burger, Adrian Wong, Nils Peters, Susana Muñoz-Maniega, Yusuke Yakushiji, David Calvet, Mark White, Michael McCormick, Vinodh Krishnamurthy, David Hargroves, Jan C. Purrucker, Tae Jin Song, Masayuki Shiozawa, Noortje A.M. Maaijwee, Prasanna Aghoram, Nicolas Christ, Lino Ramos, Yannie Soo, Thanh G. Phan, Parashkev Nachev, David J. Seiffge, Kim Wiegertjes, Leo H. Bonati, Chahin Pachai, Oi Ling Chan, Yvo B.W.E.M. Roos, Santiago Medrano-Martorell, Natan M. Bornstein, Elizabeth A. Warburton, Richard Li, Prabel Datta, Pascal P. Gratz, Edmund Ka Ming Wong, Hedley C. A. Emsley, Marie-Yvonne Douste-Blazy, Gunaratam Gunathilagan, Nagaendran Kandiah, Masatoshi Koga, Roland Veltkamp, Lee-Anne Slater, Suk Fung Tsang, Beom Joon Kim, Simon Jung, Zeynep Tanriverdi, Sarah Caine, Peter J. Koudstaal, Laurence Legrand, Kari Saastamoinen, Ale Algra, Jean-Louis Mas, Christine Delmaire, Fidel Nuñez, Robert J. van Oostenbrugge, Sebastian Eppinger, Lillian Choy, Robert Luder, Vincent I.H. Kwa, Aad van der Lugt, Marie Dominique Fratacci, Stephen Makin, Layan Akijian, Régis Bordet, Mi Hwa Yang, Ying Zhou, Elio Giallombardo, Adrian R Parry-Jones, John S. Thornton, Amos D. Korczyn, Narayanaswamy Venketasubramanian, David J. Williams, Aravindakshan Manoj, Julie Staals, Solveig Horstmann, Dianne H.K. van Dam-Nolen, Claire Cullen, Benjamin Wagner, Jun Tanaka, Martin Dennis, Stef Bakker, Gregory Y.H. Lip, L. Jaap Kappelle, Robin Lemmens, Achim Gass, David Mangion, Matthew Smith, Toshio Imaizumi, Wenyan Liu, Jeremy Molad, Christopher Price, Paul J. Nederkoorn, P. J. A. M. Brouwers, Vincent Thijs, Sze Ho Ma, Mark Schembri, Peter Wilkinson, Janice E. O’Connell, Karen Ma, John Ly, Leonidas Panos, Chung Yan Chan, Toshihiro Ide, Christopher Traenka, Joost Jöbsis, Gargi Banerjee, Paul Berntsen, Michael J. Thrippleton, Raymond T.F. Cheung, Christopher Karayiannis, Werner H. Mess, Robert Simister, Jayesh Modi Medanta, Syuhei Ikeda, John Mitchell, Linxin Li, Mauro S.B. Silva, Eric Vicaut, John Coyle, Shoichiro Sato, Michelle Davis, Jonathan Birns, Richard J. Perry, Sean M. Murphy, KC Teo, Maria del C. Valdés Hernández, Bibek Gyanwali, Tarek A. Yousry, Kath Pasco, Sebastian Köhler, Joachim Fladt, Edward S. Hui, Philippe Lyrer, Young Dae Kim, Anna K. Heye, Eric E. Smith, Saima Hilal, Ender Uysal, Ji Hoe Heo, Ysoline Beigneux, Cisca Linn, Hee-Joon Bae, Simon Leach, Winnie C.W. Chu, Ronil V. Chandra, Neurology, ACS - Atherosclerosis & ischemic syndromes, ANS - Neurovascular Disorders, MUMC+: HZC Med Staf Spec Klinische Neurofys (9), RS: Carim - B06 Imaging, MUMC+: HZC Klinische Neurofysiologie (5), Klinische Neurowetenschappen, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Neurologie (3), RS: Carim - B05 Cerebral small vessel disease, MUMC+: Hersen en Zenuw Centrum (3), MUMC+: MA Med Staf Spec Neurologie (9), RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Beeldvorming, and MUMC+: DA BV Klinisch Fysicus (9)
Subjects: Adult, Male, Risk, EXTERNAL VALIDATION, medicine.medical_specialty, Neurology, MODELS, Clinical Neurology, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Recurrence, Internal medicine, Antithrombotic, Humans, Medicine, Prospective cohort study, 610 Medicine & health, Stroke, METAANALYSIS, Aged, Ischemic Stroke, Science & Technology, medicine.diagnostic_test, business.industry, Proportional hazards model, Magnetic resonance imaging, Middle Aged, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], medicine.disease, Magnetic Resonance Imaging, Ischemic Attack, Transient, ATRIAL-FIBRILLATION, Cardiology, Female, Neurology (clinical), Neurosciences & Neurology, business, Intracranial Hemorrhages, Life Sciences & Biomedicine, 030217 neurology & neurosurgery, Fibrinolytic agent, Cohort study
Abstract: Contains fulltext : 235277.pdf (Publisher’s version ) (Closed access) BACKGROUND: Balancing the risks of recurrent ischaemic stroke and intracranial haemorrhage is important for patients treated with antithrombotic therapy after ischaemic stroke or transient ischaemic attack. However, existing predictive models offer insufficient performance, particularly for assessing the risk of intracranial haemorrhage. We aimed to develop new risk scores incorporating clinical variables and cerebral microbleeds, an MRI biomarker of intracranial haemorrhage and ischaemic stroke risk. METHODS: We did a pooled analysis of individual-patient data from the Microbleeds International Collaborative Network (MICON), which includes 38 hospital-based prospective cohort studies from 18 countries. All studies recruited participants with previous ischaemic stroke or transient ischaemic attack, acquired baseline MRI allowing quantification of cerebral microbleeds, and followed-up participants for ischaemic stroke and intracranial haemorrhage. Participants not taking antithrombotic drugs were excluded. We developed Cox regression models to predict the 5-year risks of intracranial haemorrhage and ischaemic stroke, selecting candidate predictors on biological relevance and simplifying models using backward elimination. We derived integer risk scores for clinical use. We assessed model performance in internal validation, adjusted for optimism using bootstrapping. The study is registered on PROSPERO, CRD42016036602. FINDINGS: The included studies recruited participants between Aug 28, 2001, and Feb 4, 2018. 15 766 participants had follow-up for intracranial haemorrhage, and 15 784 for ischaemic stroke. Over a median follow-up of 2 years, 184 intracranial haemorrhages and 1048 ischaemic strokes were reported. The risk models we developed included cerebral microbleed burden and simple clinical variables. Optimism-adjusted c indices were 0·73 (95% CI 0·69-0·77) with a calibration slope of 0·94 (0·81-1·06) for the intracranial haemorrhage model and 0·63 (0·62-0·65) with a calibration slope of 0·97 (0·87-1·07) for the ischaemic stroke model. There was good agreement between predicted and observed risk for both models. INTERPRETATION: The MICON risk scores, incorporating clinical variables and cerebral microbleeds, offer predictive value for the long-term risks of intracranial haemorrhage and ischaemic stroke in patients prescribed antithrombotic therapy for secondary stroke prevention; external validation is warranted. FUNDING: British Heart Foundation and Stroke Association.
Published: 2021
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32. Comparison of novel recombinant nucleoprotein ELISA with commercial ELISA for Newcastle disease

Author: Jihoon Ryu, Hyeon Yoon, Hyun-Jin Shin, and Ho-Jin Moon
Subjects: animal structures, animal diseases, viruses, Outbreak, Biology, medicine.disease_cause, biology.organism_classification, Newcastle disease, Virology, Virus, Nucleoprotein, law.invention, law, Statistical analyses, embryonic structures, medicine, Recombinant DNA, Elisa method, Escherichia coli
Abstract: In the present study, a novel ELISA method used recombinant nucleocapsid protein (rNP) as the coating agent. Recombinant Newcastle disease virus (NDV) protein was cloned and expressed in Escherichia coli. Though the rNP-ELISA results were consistent with commercial ELISA results for the NDV-negative sera samples, qualitatively and quantitatively variable (often reduced) results were obtained with NDV-positive sera. Although the rNP-ELISA results for NDV detection were inconclusive, further improvement and standardization of the rNP-ELISA approach, such as using multiple recombinant proteins as the ELISA coating agent and performing comprehensive statistical analyses of combined recombinant protein ELISA, should help counter Newcastle disease outbreaks by improving NDV detection.
Published: 2021
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33. Germline and Tumor Sequencing as a Diagnostic Tool To Resolve Suspected Lynch Syndrome

Author: Finlay A. Macrae, Amanda B. Spurdle, Romy Walker, Christophe Rosty, Bernard J. Pope, Ryan Hutchinson, Jihoon E. Joo, Susan Preston, Ingrid Winship, Peter Georgeson, John L. Hopper, Mark Clendenning, Daniel D. Buchanan, Mark A. Jenkins, Julia Como, Aung Ko Win, Harindra Jayasekara, Khalid Mahmood, and Sharelle Joseland
Subjects: Adult, Male, 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Somatic cell, Gene mutation, Biology, MLH1, complex mixtures, Germline, Pathology and Forensic Medicine, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Neoplastic Syndromes, Hereditary, Neoplasms, Exome Sequencing, medicine, Humans, Germ-Line Mutation, Aged, Genetics, Whole Genome Sequencing, Brain Neoplasms, Computational Biology, High-Throughput Nucleotide Sequencing, Reproducibility of Results, Regular Article, Middle Aged, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, digestive system diseases, Lynch syndrome, Pedigree, 030104 developmental biology, MSH2, 030220 oncology & carcinogenesis, DNA methylation, Molecular Medicine, Female, DNA mismatch repair, Colorectal Neoplasms
Abstract: Patients in whom mismatch repair (MMR)-deficient cancer develops in the absence of pathogenic variants of germline MMR genes or somatic hypermethylation of the MLH1 gene promoter are classified as having suspected Lynch syndrome (SLS). Germline whole-genome sequencing (WGS) and targeted and genome-wide tumor sequencing were applied to identify the underlying cause of tumor MMR deficiency in SLS. Germline WGS was performed on samples from 14 cancer-affected patients with SLS, including two sets of first-degree relatives. MMR genes were assessed for germline pathogenic variants, including complex structural rearrangements and noncoding variants. Tumor tissue was assessed for somatic MMR gene mutations using targeted, whole-exome sequencing or WGS. Germline WGS identified pathogenic MMR variants in 3 of the 14 cases (21.4%), including a 9.5-megabase inversion disrupting MSH2 in a mother and daughter. Excluding these 3 MMR carriers, tumor sequencing identified at least two somatic MMR gene mutations in 8 of 11 tumors tested (72.7%). In a second mother–daughter pair, a somatic cause of tumor MMR deficiency was supported by the presence of double somatic MSH2 mutations in their respective tumors. More than 70% of SLS cases had double somatic MMR mutations in the absence of germline pathogenic variants in the MMR or other DNA repair–related genes on WGS, and, therefore, were confidently assigned a noninherited cause of tumor MMR deficiency.
Published: 2021
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34. Unusual Presentation of Anal Pain and Tenesmus from Rectal Arteriovenous Malformation Successfully Treated with Ethanol Sclerotherapy

Author: Jun Heo, Sang Yub Lee, Jihoon Hong, and Jung Guen Cha
Subjects: medicine.medical_specialty, Percutaneous, medicine.medical_treatment, Single Case, arteriovenous malformation, Rectum, Colonoscopy, Inferior mesenteric artery, transarterial ethanol sclerotherapy, 03 medical and health sciences, Superior rectal vein, 0302 clinical medicine, anal pain, medicine.artery, medicine, Sclerotherapy, rectum, lcsh:RC799-869, tenesmus, medicine.diagnostic_test, business.industry, Gastroenterology, Arteriovenous malformation, medicine.disease, Surgery, medicine.anatomical_structure, medicine.vein, 030220 oncology & carcinogenesis, Angiography, 030211 gastroenterology & hepatology, lcsh:Diseases of the digestive system. Gastroenterology, business
Abstract: Gastrointestinal arteriovenous malformation (AVM) is reported as one of the possible causes of intestinal bleeding, and its occurrence in the rectum is rare. We report the case of a rectal AVM patient who experienced uncommon symptoms of anal pain and tenesmus and was treated successfully with percutaneous transarterial ethanol sclerotherapy. The patient underwent routine colonoscopy with biopsy at the time of visit; however, an accurate diagnosis was difficult. Subsequent contrast-enhanced computed tomography (CT) and angiography revealed a rectal AVM emerging from the distal inferior mesenteric artery with engorged superior rectal veins. The feeding artery was catheterized, and concurrent transarterial sclerotherapy with 80% ethanol was performed. There was no major complication related to the procedure. Disappearance of AVM nidus and improvement of associated venous congestion were shown by follow-up CT. There was no recurrence of symptoms after 10 months of clinical observation. Transarterial ethanol sclerotherapy is safe and effective in treating rectal AVM and can be considered as one of the nonsurgical treatment options.
Published: 2021

35. Predisposing factors of persistent storage symptoms after holmium laser enucleation of the prostate in patients with benign prostatic hyperplasia and their correlations to the symptom recovery period

Author: Jihoon Park, Jeong Zoo Lee, Yangkyu Park, Hyeon Woo Kim, and Dong Gil Shin
Subjects: medicine.medical_specialty, Multivariate analysis, 010405 organic chemistry, Chemistry, Enucleation, Urology, General Chemistry, Hyperplasia, urologic and male genital diseases, 010402 general chemistry, Condensed Matter Physics, medicine.disease, 01 natural sciences, 0104 chemical sciences, Bladder outlet obstruction, medicine.anatomical_structure, Overactive bladder, Prostate, Lower urinary tract symptoms, medicine, In patient, Food Science
Abstract: Bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH) is the most common cause of lower urinary tract symptoms (LUTS) in older men. Although medical treatments can reduce BPH-related LUTS and even prevent invasive treatments, at least one in five men who complain of LUTS due to BPH will eventually need surgery. Of LUTS, storage symptoms persist in 20 to 40% of patients even after the obstruction is resolved. The present study aims to investigate the predisposing factors of the persistent storage symptoms after HoLEP in patients with BPH and their correlations to the recovery time of the symptoms. A total of 127 patients with complaints of storage symptoms and who underwent transurethral HoLEP surgery at Pusan National University Hospital from May 2014 to June 2017 were included in this study. Urodynamic studies were performed in all patients, and BOO was confirmed by urodynamic studies before HoLEP. All patients were asked to complete the IPSS (also known as the American Urological Association score) and the Overactive Bladder Symptom Score (OABSS) questionnaire to evaluate LUTS on the day before HoLEP and 3 months after HoLEP. Patients were divided into group I, which included patients with persistent storage symptoms after HoLEP, and group II, which included patients without storage symptoms after HoLEP. Of a total of 127 patients, 68 were included in group I, and the remaining 59 were included in group II. In the univariable analysis, group I showed statistically significantly older mean age, higher mean peak detrusor pressure during filling cystometry, and lower mean MCC than group II. Multivariate analysis of these three variables showed that only mean age and mean peak detrusor pressure during filling cystometry had statistically significant differences. In group I, 12 patients had storage symptoms until 12 months after surgery. When comparing these patients with the remaining 56 patients, only mean age showed statistically significant differences. Old age and high peak detrusor pressure during filling cystometry were the predictors of persistent storage symptoms after HoLEP. Furthermore, older patients were unlikely to recover storage symptoms until 12 months after operation.
Published: 2021
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36. Decreased cardiovascular death in schizophrenia patients treated with antipsychotics: A Korean national cohort study

Author: Jeong-Ho Chae, Tae-Suk Kim, Jihoon Oh, Sangmin Park, and Hyewon Nam
Subjects: medicine.medical_specialty, medicine.medical_treatment, Population, Disease, Cohort Studies, Benzodiazepines, Quetiapine Fumarate, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Republic of Korea, medicine, Humans, Antipsychotic, education, Biological Psychiatry, Cause of death, education.field_of_study, business.industry, Mortality rate, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Schizophrenia, Cohort, business, 030217 neurology & neurosurgery, Antipsychotic Agents
Abstract: Background Patients with schizophrenia have a reduced life expectancy, but the association between antipsychotic usage and cause of death is uncertain. Methods The authors observed associations of antipsychotic usage with the mortality rate and cause of death in a population-based cohort of the Korean National Health Insurance Service database from 2003 to 2017. A total of 86,923 patients with schizophrenia were categorized by the total duration of antipsychotic prescription after schizophrenia diagnosis into treated (n = 77,139) and untreated (n = 9784) groups. The main outcome was all-cause mortality; causes of death included cardiovascular disease, pulmonary disease, diabetes, cancer, accident, suicide and homicide. Results The numbers of all-cause deaths and deaths from individual causes were significantly lower in the antipsychotic-treated group than in the untreated group (all cases, p Conclusions Schizophrenia patients constantly prescribed antipsychotics had significantly lower rates of death from certain cardiovascular illnesses than untreated patients. Aripiprazole-treated schizophrenia was associated with a decreased risk of death compared with olanzapine-treated disease.
Published: 2021
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37. Characteristics and Prognostic Factors of Recurrence after Hemithyroidectomy in Patients with Papillary Thyroid Microcarcinoma

Author: Dongbin Ahn, Jin Ho Sohn, Gil Joon Lee, and Jihoon Lee
Subjects: medicine.medical_specialty, business.industry, medicine.medical_treatment, Thyroidectomy, Papillary Thyroid Microcarcinoma, 030209 endocrinology & metabolism, 03 medical and health sciences, 0302 clinical medicine, Otorhinolaryngology, 030220 oncology & carcinogenesis, medicine, Surgery, In patient, Radiology, business
Abstract: Background and Objectives The incidence of papillary thyroid microcarcinoma (PTMC) continues to increase worldwide. However, there is a lack of a comprehensive understanding of recurrence after hemithyroidectomy in patients with PTMC. We aimed to evaluate the characteristics and risk factors of recurrence after hemithyroidectomy in patients with PTMC.Subjects and Method We included 527 patients with PTMC who underwent hemithyroidectomy between 2009 and 2017.Results At a mean follow-up of 76.4 months after hemithyroidectomy, recurrence occurred in 4.2% (22/527) of the patients. The times of recurrence were 60 months after initial surgery in 1 (4.5%), 6 (27.3%), 5 (22.7%), 4 (18.2%), 4 (18.2%), and 2 (9.1%) patient(s), respectively. The most common recurrence site was the contralateral remaining thyroid lobe. In univariate analyses, only multifocality was demonstrated to be associated with an increased risk of recurrence [hazard ratio (HR), 2.834; confidence interval (CI), 1.044-7.693; p=0.041). In multivariate analyses, multifocality (HR, 2.982; CI, 1.091-8.155; p=0.033) and central lymph node metastasis (HR, 9.649; CI, 1.238-75.217; p=0.030) were demonstrated to be associated with an increased risk of recurrence.Conclusion The follow-up after hemithyroidectomy for PTMC should focus on the postoperative 1–5-year period with meticulous inspection of the remaining thyroid lobe, particularly in patients with multifocality or central lymph node metastasis.
Published: 2021
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38. Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion

Author: Jihoon Kang, Sang Jun Park, Yong Dae Kim, Cheolkyu Jung, Jun Yup Kim, Sung Hyun Baik, Young Joo Park, and Se Joon Woo
Subjects: Male, medicine.medical_specialty, Retinal Artery Occlusion, Science, Infarction, Brain imaging, Disease, Article, Brain Ischemia, Lesion, 03 medical and health sciences, 0302 clinical medicine, Neuroimaging, Leukoencephalopathies, Internal medicine, medicine, Humans, Aged, Cerebral Hemorrhage, Retrospective Studies, Multidisciplinary, medicine.diagnostic_test, business.industry, Brain, Magnetic resonance imaging, Cerebral Infarction, Middle Aged, Atherosclerosis, medicine.disease, Magnetic Resonance Imaging, White Matter, Retinal diseases, Stroke, Cerebral Small Vessel Diseases, Stroke, Lacunar, 030221 ophthalmology & optometry, Etiology, Cardiology, Medicine, Female, Small vessel, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: There are several reports in the literature on the association between non-arteritic retinal artery occlusion (NA-RAO) and acute ischemic stroke. We investigated the burden of small vessel disease (SVD) and cerebral coincident infarction observed on cerebral magnetic resonance imaging (MRI) in patients with newly diagnosed NA-RAO. In this retrospective, observational, case-series study, consecutive patients with NA-RAO who underwent cerebral MRI within one month of diagnosis between September 2003 and October 2018 were included. The classification of NA-RAO was based on ophthalmologic and systemic examinations. We also investigated the co-incident infarction and burden of underlying SVD, which were categorized as white matter hyperintensity lesion (WMH), cerebral microbleeds (CMB), and silent lacunar infarction (SLI). Among the 272 patients enrolled in the study, 18% presented co-incident infarction and 73% had SVD, which included WMH (70%), CMB (14%), and SLI (30%). Co-incident infarction, WMH, and SLI significantly increased with age: co-incident infarction was observed in 8% of young (P = 0.002) and co-incident infarction (30%: 19%: 8%; P = 0.009). Therefore, high co-incidence of acute cerebral infarction and underlying SVD burden warrant careful neurologic examination and appropriate brain imaging, followed by management of NA-RAO. Urgent brain imaging is particularly pertinent in elderly patients with NA-RAO.
Published: 2021

39. High-Dose Prednisolone Therapy for Lennox–Gastaut Syndrome Caused by Fentanyl Intoxication-Induced Toxic Leukoencephalopathy

Author: Jihoon Na, Hui Jin Shin, Young Mock Lee, and Hyun Joo Lee
Subjects: medicine.medical_specialty, business.industry, Neurosciences. Biological psychiatry. Neuropsychiatry, medicine.disease, RC31-1245, Gastroenterology, Fentanyl, Toxic leukoencephalopathy, Neurology, Internal medicine, Pediatrics, Perinatology and Child Health, Prednisolone, medicine, Neurology. Diseases of the nervous system, Neurology (clinical), RC346-429, business, RC321-571, medicine.drug, Lennox–Gastaut syndrome
Published: 2021
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40. Measurements of the inclusive and differential production cross sections of a top-quark-antiquark pair in association with a Z boson at √s = 13 TeV with the ATLAS detector

Author: Aad, Georges, Abbott, Braden Keim, Abbott, Dale, Abed Abud, Adam, Abeling, Kira, Abhayasinghe, Deshan Kavishka, Abidi, Haider, Abouzeid, Hass, Abouzeid, Ossama, Abraham, Nicola Louise, Abramowicz, Halina, Abreu, Henso, Abulaiti, Yiming, Acharya, Bobby Samir, Achkar, Baida, Adam, Lennart, Adam Bourdarios, Claire, Adamczyk, Leszek, Adamek, Lukas, Adelman, Jahred, Adiguzel, Aytul, Adorni Braccesi Chiassi, Sofia, Adye, Tim, Adye, Timothy John, Affolder, Tony, Affolder, Anthony, Afik, Yoav, Agapopoulou, Christina, Agaras, Merve Nazlim, Aggarwal, Anamika, Agheorghiesei, Catalin, Aguilar Saavedra, Juan Antonio, Ahmad, Ammara, Ahmadov, Faig, Ahmed, Waleed Syed, Ai, Xiaocong, Aielli, Giulio, Akatsuka, Shunichi, Akbiyik, Melike, Akesson, Torsten, Akilli, Ece, Akimov, Andrei, Al Khoury, Konie, Alberghi, Gian Luigi, Albert, Justin, Verzini, M.J. Alconada, Alderweireldt, Sara, Aleksa, Martin, Aleksandrov, I.N., Alexa, Calin, Alexopoulos, Theodoros, Alfonsi, Alice, Alfonsi, Fabrizio, Alhroob, Muhammad, Ali, Babar, Ali, Shahzad, Aliev, Malik, Alimonti, Gianluca, Allaire, Corentin, Allbrooke, Benedict, Allen, Benjamin William, Allport, Philip Patrick, Aloisio, Alberto, Alonso, Francisco, Alpigiani, Cristiano, Alunno Camelia, Elio, Alvarez Estevez, Manuel, Alviggi, Mariagrazia, Do Amaral Coutinho, Yara, Ambler, Alessandro, Ambroz, Luca, Amelung, Christoph, Amidei, Dante, Amor dos Santos, Susana Patricia, Amoroso, Simone, Amrouche, Cherifa Sabrina, An, Fenfen, Anastopoulos, Christos, Andari, Nansi, Andeen, Timothy Robert, Anders, John Kenneth, Andrean, Stefio Yosse, Andreazza, Attilio, Andrei, Victor, Anelli, Christopher Ryan, Angelidakis, Stylianos, Angerami, Aaron, Anisenkov, Alexey, Annovi, Alberto, Antel, Claire, Anthony, Matthew Thomas, Antipov, Egor, Antonelli, Mario, Antrim, Daniel Joseph, Anulli, Fabio, Aoki, Masato, Aparisi Pozo, Javier Alberto, Aparo, Marco, Aperio Bella, Ludovica, Aranzabal Barrio, Nordin, Araujo Ferraz, Victor, Pereira, R.Araujo, Arcangeletti, Chiara, Arce, Ayana Tamu, Arguin, Jean-Francois, Argyropoulos, Spyros, Argyropoulos, Spyridon, Arling, Jan-Hendrik, Armbruster, Aaron James, Armstrong, Alexander, Arnaez, Olivier, Arnold, Hannah, Arrubarrena Tame, Zulit Paola, Artoni, Giacomo, Asada, Haruka, Asai, Kanae, Asai, Shoji, Asawatavonvanich, Thanawat, Asbah, Nedaa Alexandra, Asimakopoulou, Eleni Myrto, Asquith, Lily, Assahsah, Jihad, Assamagan, Ketevi Adikle, Astalos, Robert, Atkin, Ryan Justin, Atkinson, Markus Julian, Atlay, Naim Bora, Atmani, Hicham, Atmasiddha, Prachi, Augsten, Kamil, Austrup, Volker Andreas, Avolio, Giuseppe, Ayoub, Mohamad Kassem, Azuelos, Georges, Babal, Dominik, Bachacou, Henri, Bachas, Dinos, Bachas, Konstantinos, Backman, Karl Filip, Bagnaia, Paolo, Bahrasemani, H., Bahrasemani, Sina, Bailey, Adam, Bailey, Virginia, Baines, John, Bakalis, Christos, Baker, Keith, Bakker, Pepijn Johannes, Bakos, Evelin, Bakshi Gupta, Debottam, Balaji, Shyam, Balasubramanian, Rahul, Baldin, Evgenii, Balek, Petr, Balli, Fabrice, Balunas, William Keaton, Balz, Johannes, Banas, Elzbieta, Bandieramonte, Marilena, Bandyopadhyay, Anjishnu, Banerjee, Sw., Banerjee, Swagato, Barak, Liron, Barbe, William Mickael, Barberio, Elisabetta, Barberis, Dario, Barbero, Marlon Benoit, Barbour, Gregory, Barillari, Teresa, Barisits, Martin, Barkeloo, Jason Tyler Colt, Barklow, Tim, Barklow, Timothy Laurence, Barnea, Rotem, Barnett, Bruce M, Barnett, Michael, Barnovska-Blenessy, Z., Baroncelli, Toni, Baroncelli, Antonio, Barone, Gaetano, Barr, Alan, Barranco Navarro, Laura, Barreiro Alonso, Fernando, Barreiro Guimaraes da Costa, Joao, Barron, Uriel, Barsov, Sergey, Bartels, Falk, Bartoldus, Rainer, Bartolini, Giovanni, Barton, Adam Edward, Bartos, Pavol, Basalaev, Artem, Basan, Alexander, Bassalat, Ahmed, Basso, Matthew Joseph, Bates, Richard, Batlamous, Souad, Batley, Richard, Batool, Binish, Battaglia, Marco, Bauce, Matteo, Bauer, Florian, Bauer, Patrick, Bawa, Harinder Singh, Bayirli, Arif, Beacham, James, Beau, Tristan, Beauchemin, Pierre-Hugues, Becherer, Fabian, Bechtle, Philip, Beck, Helge Christoph, Beck, Hans Peter, Beck, Hanspeter, Becker, Kathrin, Becot, Cyril Pascal, Beddall, Ayda, Beddall, Andrew, Bednyakov, Vadim, Bedognetti, Matteo, Bee, Chris, Bee, Christopher Peter, Beermann, Thomas, Begalli, Marcia, Begel, Michael, Behera, Arabinda, Behr, Janna Katharina, Beisiegel, Florian, Belfkir, Mohamed, Bell, Andrew Stuart, Bella, Gideon, Bellagamba, Lorenzo, Bellerive, Alain, Bellos, Panagiotis, Beloborodov, Konstantin, Belotskiy, Konstantin, Belyaev, Nikita, Benchekroun, Driss, Benekos, Nectarios, Benhammou, Yan, Benjamin, Doug, Benjamin, Douglas Paul, Benoit, Mathieu, Bensinger, Jim, Bensinger, James, Bentvelsen, Stan, Bentvelsen, Stanislaus, Beresford, Lydia Audrey, Beretta, Matteo Mario, Berge, David, Bergeaas Kuutmann, Elin, Berger, Nicolas, Bergmann, Benedikt Ludwig, Bergsten, Laura Jean, Beringer, Juerg, Berlendis, Simon, Bernardi, Gregorio, Bernius, Catrin, Bernlochner, Florian Urs, Berry, Tracey, Berta, Peter, Berthold, Anne-Sophie, Bertram, Iain, Bessidskaia Bylund, Olga, Besson, Nathalie, Bethke, Siegfried, Betti, Alessandra, Bevan, Adrian, Beyer, Julien-Christopher, Bhatta, Somadutta, Bhattacharya, Deb Sankar, Bhattarai, Prajita, Bhopatkar, Vallary Shashikant, Bi, Runyu, Bianchi, Riccardo Maria, Biebel, Otmar, Biedermann, Dustin, Bielski, Rafal, Bierwagen, Katharina, Biesuz, Nicolo Vladi, Biglietti, Michela, Billoud, T.R. V., Bindi, Marcello, Bingul, Ahmet, Bini, Cesare, Biondi, Silvia, Birch-Sykes, Callum Jacob, Birman, Mattias, Bisanz, Tobias, Biswal, Jyoti Prakash, Biswas, Diptaparna, Bitadze, Alexander, Bittrich, Carsten, Bjoerke, Kristian, Blazek, Tomas, Bloch, Ingo, Blocker, Craig, Blue, Andrew James, Blumenschein, Ulla, Blumenschein, Heidrun, Bobbink, Gerjan, Bobbink, Gerard, Bobrovnikov, Viktor, Bocchetta, Simona, Bogavac, Danijela, Bogdanchikov, Alexander, Bohm, Christian, Boisvert, Veronique, Bokan, Petar, Bold, Tomasz, Bolz, Arthur Eugen, Bomben, Marco, Bona, Marcella, Bonilla, Johan Sebastian, Boonekamp, Maarten, Booth, Callum Dale, Borbely, Albert Gyorgy, Borecka-Bielska, Hanna Maria, Borgna, Lucas Santiago, Borisov, Anatoli, Borissov, Guennadi, Bortoletto, Daniela, Boscherini, Davide, Fernandez-Bosman, Martine, Sola, J.D. Bossio, Bouaouda, Khalil, Boudreau, Joseph, Bouhova-Thacker, E.V., Bouhova-Thacker, Evelina Vassileva, Boumediene, Djamel Eddine, Boveia, Antonio, Boyd, Jamie, Boyd, James, Boye, Diallo, Boyko, Igor, Bozson, Adam, Bracinik, Juraj, Brahimi, Nihal, Brandt, Gerhard Immanuel, Brandt, Oleg, Braren, Frued Erik, Brau, Benjamin Paul, Brau, J.E., Brau, James Edward, Breaden Madden, Will, Breaden Madden, William Dmitri, Brendlinger, Kurt, Schimmel Brener, Roy, Brenner, Lydia, Brenner, Richard, Bressler, Shikma, Brickwedde, Bernard, Briglin, Daniel Lawrence, Britton, David, Britzger, Daniel Andreas, Brock, Ian, Brock, Raymond, Brooijmans, Gustaaf, Brooks, William King, Brost, Elizabeth, Bruckman de Renstrom, Pawel, Bruers, Ben, Bruncko, Dusan, Bruni, Alessia, Bruni, Graziano, Bruschi, Marco, Bruscino, Nello, Bryngemark, Lene Kristian, Buanes, Trygve, Buat, Quentin, Buchholz, Peter, Buckley, Andy, Budagov, Ioulian, Buckley, Andrew Gordon, Budagov, Yulian, Bugge, Magnar Kopangen, Bulekov, Oleg, Bullard, Brendon, Burch, Tyler James, Burdin, Sergey, Burgard, Carsten Daniel, Burger, Angela Maria, Burghgrave, Blake Oliver, Burr, Jon, Burr, Jonathan, Burton, Charles, Burzynski, Jackson Carl, Buescher, Volker, Buschmann, Eric, Bussey, Peter John, Butler, John Mark, Buttar, Craig, Butterworth, Jonathan, Butti, Pierfrancesco, Buttinger, Will, Buttinger, William, Buxo Vazquez, Carlos Josue, Buzatu, Adrian, Buzykaev, Alexey, Buzykaev, Aleksey, Cabras, Grazia, Cabrera Urban, Susana, Caforio, Davide, Cai, Huacheng, Cairo, Valentina, Cakir, Orhan, Calace, Noemi, Calafiura, Paolo, Calderini, Giovanni, Calfayan, Philippe, Callea, Giuseppe, Caloba, Luiz, Caltabiano, Alessandro, Calvente Lopez, Sergio, Calvet, David, Calvet, Samuel, Calvet, Thomas Philippe, Calvetti, Milene, Camacho Toro, Reina Coromoto, Camarda, Stefano, Camarero Munoz, Daniel, Camarri, Paolo, Camerlingo, Maria Teresa, Cameron, David, Camincher, Clement, Campana, Simone, Campanelli, Mario, Camplani, Alessandra, Canale, Vincenzo, Canesse, Auriane, Bret Cano, Marc, Cantero Garcia, Josu, Cao, Tingting, Cao, Yumeng, Garrido, M.D. M.Capeans, Capua, Marcella, Cardarelli, Roberto, Cardillo, Fabio, Carducci, Giovandomenico, Carli, Ina, Carli, Tancredi, Carlino, Giampaolo, Carlson, B.T., Carlson, Benjamin Taylor, Carlson, Evan Michael, Carminati, Leonardo, Carney, Rebecca, Caron, Sascha, Carquin Lopez, Edson, Carra, Sonia, Carratta, Giuseppe, Carter, J.W. S., Carter, Thomas Michael, Casado Lechuga, Pilar, Casha, Albert Francis, Castiglia, Emma Grace, Castillo, Florencia Luciana, Castillo Garcia, Lucia, Castillo Gimenez, Victoria, Castro, Nuno, Catinaccio, Andrea, Catmore, James, Cattai, Ariella, Cavaliere, Viviana, Cavasinni, Vincenzo, Celebi, Emre, Celli, Federico, Cerny, Karel, Santiago Cerqueira, Augusto, Cerri, Alex, Cerri, Alessandro, Cerrito, Lucio, Cerutti, Fabio, Cervelli, Alberto, Cetin, Serkant, Chadi, Zakaria, Chakraborty, Dhiman, Chan, Jay, Chan, Chen-Hsun, Chan, Terry Ws, Chan, Wing Sheung, Chan, Wai Yuen, Chapman, John Derek, Chargeishvili, Bakar, Charlton, Dave, Charlton, David, Charman, Thomas Paul, Chatterjee, Meghranjana, Chau, Chav Chhiv, Che, Siinn, Chekanov, Sergei, Chekulaev, Sergey, Chelkov, G.A., Chen, Boping, Chen, Cheng, Chen, Chunhui, Chen, Huirun, Chen, Hucheng, Chen, Jing, Chen, Jue, Chen, Jiayi, Chen, Shion, Chen, Shenjian, Chen, Xin, Chen, Ye, Chen, Yu-Heng, Cheng, Hok Chuen, Cheng, Huajie, Cheplakov, Alexander, Cheremushkina, Evgeniya, Cherkaoui El Moursli, Rajaa, Cheu, Elliott, Cheung, Kingman, Chevalerias, Thibault, Chevalier, Laurent, Chiarella, Vitaliano, Chiarelli, Giorgio, Chiodini, Gabriele, Chisholm, Andrew Stephen, Chitan, Adrian, Chiu, I-Huan, Chiu, Justin, Chiu, Y.H., Chizhov, Mihail, Choi, Kyungeon, Chomont, Arthur, Chou, Yuan-Tang, Chow, Edwin, Chow, Yun Sang, Christopher, Lawrence Davou, Chu, Ming Chung, Chu, Xiaotong, Chudoba, Jiri, Chwastowski, Janusz, Chytka, Ladislav, Cieri, Davide, Ciesla, Krzysztof, Cindro, Vladimir, Cioara, Irina Antonela, Ciocio, Alessandra, Cirotto, Francesco, Citron, Z.H., Citterio, Mauro, Ciubotaru, Dan Andrei, Ciungu, Bianca Monica, Clark, Allan, Clark, Philip, Clawson, Savannah, Clement, Christophe, Coadou, Yann, Cobal, Marina, Coccaro, Andrea, Cochran, James Herbert, Coelho Lopes de Sa, Rafael, Cohen, Hadar, Coimbra, A.E. C., Cole, Brian, Colijn, Auke-Pieter, Collot, Johann, Conde Muino, Patricia, Connell, Simon, Connelly, Ian Allan, Constantinescu, Serban, Conventi, Francesco, Cooper-Sarkar, A.M., Cormier, Felix, Cormier, Kyle James Read, Corpe, Louie Dartmoor, Corradi, Massimo, Corrigan, Eric Edward, Corriveau, Francois, Costa Mezquita, Maria Jose, Costanza, Francesco, Costanzo, Davide, Cowan, Glen, Cowley, James William, Crane, Jonathan, Cranmer, Kyle Stuart, Creager, Rachael Ann, Crepe-Renaudin, Sabine, Crescioli, Francesco, Cristinziani, Markus, Croft, Vincent Alexander, Crosetti, Giovanni, Dandoy, Jeffrey Rogers, Crosetti, Nanni, Cueto Gomez, Ana Rosario, Cuhadar Donszelmann, Tulay, Cui, Han, Cukierman, Aviv Ruben, Cunningham, William Reilly, Cunningham, Liam, Czekierda, Sabina Anna, Czodrowski, Patrick Karl, Czurylo, Marta Maja, da Cunha Sargedas de Sousa, M.J., da Fonseca Pinto, Joao Victor, da Via, Cinzia, Dabrowski, Wladyslaw, Dachs, Florian, Dado, Tomas, Dahbi, Salah-Eddine, Dai, Tiesheng, Dallapiccola, Carlo, Dam, Mogens, d'Amen, Gabriele, d'Amico, Valerio, Damp, Johannes Frederic, Dandoy, Jeff, Daneri, Maria Florencia, Danninger, Matthias, Dao, Valerio, Darbo, Giovanni, Darbo, Nanni, Dartsi, Olympia, Dattagupta, Aparajita, Daubney, Thomas, d'Auria, Saverio, David, Claire, Davidek, Tomas, Davis, Douglas Raymond, Dawson, Ian, De, Kaushik, de Asmundis, Riccardo, de Beurs, Marcus, de Castro, Stefano, de Groot, Nicolo, de Jong, Paul, de la Torre Perez, Hector, de Maria, Antonio, de Pedis, Daniele, de Salvo, Alessandro, de Sanctis, Umberto, de Santis, Maurizio, de Santo, Antonella, de Vivie de Regie, Jean-Baptiste, Dedovich, Dmitri, Deiana, Allison Mccarn, del Peso, Jose, Delabat Diaz, Yasiel, Delgove, David, Deliot, Frederic, Delitzsch, Chris Malena, Della Pietra, Massimo, Della Volpe, Domenico, Dell'Acqua, Andrea, Dell'Asta, Lidia, Delmastro, Marco, Delporte, Charles Eliaz, Delsart, Pierre Antoine, Demers Konezny, Sarah Marie, Demichev, Mikhail, Demontigny, Gabriel, Denisov, Serguei, d'Eramo, Louis, Derendarz, Dominik Karol, Derkaoui, Jamal, Derue, Frederic, Dervan, Paul, Desch, Klaus, Dette, Karola, Deutsch, Christopher, Devesa, Maria Roberta, Deviveiros, Pier-Olivier, Di Bello, Francesco Armando, Di Ciaccio, Anna, Di Ciaccio, Lucia, Di Clemente, William Kennedy, Di Clemente, Will, Di Donato, Camilla, Di Girolamo, Alessandro, Di Gregorio, Giulia, Di Luca, Andrea, Di Micco, Biagio, Di Nardo, Roberto, Di Petrillo, Karri Folan, Di Sipio, Riccardo, Diaconu, Cristinel, de Almeida Dias, Flavia, Vale, T.Dias Do, Diaz Gutierrez, Marco Aurelio, Diaz Capriles, Federico Guillermo, Dickinson, Jennet Elizabeth, Didenko, Mariia, Diehl, Edward, Dietrich, Janet, Diez Cornell, Sergio, Diez Pardos, Carmen, Dimitrievska, Aleksandra, Ding, Wei, Dingfelder, Jochen Christian, Dittmeier, Sebastian, Dittus, Fridolin, Dittus, Fido, Djama, Fares, Djobava, Tamar, Djuvsland, Julia Isabell, Barros Do Vale, Aline, Dobre, Monica, Dodsworth, David Michael, Doglioni, Caterina, Dolejsi, Jiri, Dolezal, Zdenek, Donadelli, Marisilvia, Dong, Binbin, Donini, Julien Noce, d'Onofrio, Adelina, d'Onofrio, Monica, Dopke, Jens, Doria, Alessandra, Dova, Maria Teresa, Doyle, Anthony Terence, Doyle, Tony, Drechsler, Eric, Dreyer, Etienne, Dreyer, Timo, Drobac, Alec Swenson, Du, Dongshuo, Du Pree, Tristan Arnoldus, Duan, Yanyun, Dubinin, Filipp, Dubovsky, Michal, Dubreuil, Arnaud, Duchovni, Ehud, Duckeck, Guenter, Ducu, Otilia Anamaria, Duda, Dominik, Dudarev, Alexey, Dudder, Andreas Christian, Duffield, Emily Marie, d'Uffizi, Matteo, Duflot, Laurent, Duehrssen-Debling, Michael, Dulsen, Carsten, Dumancic, Mirta, Dumitriu, Ana Elena, Dunford, Monica, Dungs, Sascha, Duperrin, Arnaud, Yildiz, H.Duran, Ellis, Nicolas, Yildiz, Duran, Dueren, Michael Johannes, Durglishvili, Archil, Duschinger, Dirk Uwe, Dutta, Baishali, Duvnjak, Damir, Dyckes, G.I., Dyndal, Mateusz, Dysch, Samuel Dezso, Dziedzic, Bartosz Sebastian, Eggleston, Michael Glenn, Eifert, Till, Eigen, Gerald, Einsweiler, Kevin Frank, Ekelof, Tord Johan Carl, El Jarrari, Hassnae, Ellajosyula, Venugopal, Ellert, Mattias, Ellinghaus, Frank, Elliot, Alison, Emerman, Alexander Zack, Evans, Harold, Ellis, Nick, Elmsheuser, Johannes, Elsing, Markus, Emeliyanov, Dmitry, Emerman, Alex, Enari, Yuji, Epland, Matthew, Erdmann, Johannes, Ereditato, Antonio, Erland, Paula Agnieszka, Errenst, Martin, Escalier, Marc, Escobar Ibanez, Carlos, Estrada Pastor, Oscar, Etzion, Erez, Gaspar de Andrade Evans, Guiomar, Evans, Hal, Evans, Meirin Oan, Ezhilov, Aleksei, Fabbri, Federica, Fabbri, Laura, Fabiani, Veronica, Facini, Gabriel, Fakhrutdinov, Rinat, Falciano, Speranza, Falke, Peter Johannes, Falke, Saskia, Faltova, Jana, Fang, Yi, Fang, Yaquan, Fanourakis, Georgios, Fanti, Marcello, Faraj, Mohammed, Farbin, Amir, Farilla, Addolorata, Fedorko, Wojciech Tadeusz, Fell, Alexandra, Farilla, Ada, Farina, Edoardo Maria, Farooque, Trisha, Farrington, Sinead, Farthouat, Philippe, Fassi, Farida, Fassnacht, Patrick, Fassouliotis, Dimitris, Faucci Giannelli, Michele, Fawcett, William James, Fayard, Louis, Fedin, Oleg, Fedorko, Wojtek, Fehr, Armin, Feickert, Matthew Carl, Feligioni, Lorenzo, Fell, Alix, Feng, Cunfeng, Feng, Minyu, Fenton, Michael James, Fenyuk, Alexandre, Ferguson, Sarah Whitney, Ferrando, James Edward, Ferrari, Arnaud, Ferrari, Pamela, Ferrari, Roberto, Ferreira de Lima, Danilo Enoque, Ferrer Soria, Antonio, Ferrere, Didier, Ferretti, Claudio, Fiedler, Frank, Filipcic, Andrej, Filthaut, Frank, Finelli, Kevin Daniel, Castro Nunes Fiolhais, Miguel, Fiorini, Luca, Fischer, Florian, Fischer, Julian, Fisher, Wade Cameron, Fitschen, Tobias, Fleck, Ivor, Fleischmann, Philipp, Flick, Tobias, Flierl, Bernhard Matthias, Flores, Lucas Macrorie, Flores Castillo, Luis Roberto, Follega, Francesco Maria, Fomin, Nikolai, Foo, Joel Hengwei, Forcolin, Giulio Tiziano, Forland, Blake Christopher, Formica, Andrea, Forster, Fabian Alexander, Forti, Alessandra, Fortin, Etienne Marie, Foti, Maria Giovanna, Fournier, Daniel, Fox, Harald, Francavilla, Paolo, Francescato, Simone, Franchini, Matteo, Franchino, Silvia, Francis, David, Franco, Luca, Franconi, Laura, Franklin, Melissa, Frattari, Guglielmo, Fray, Antony, Freeman, Patrick Moriishi, Freund, Benjamin, Spolidoro Freund, Werner, Freundlich, Elena Murielle, Frizzell, Dylan Cooper, Froidevaux, Daniel, Frost, James, Fujimoto, Minori, Fukunaga, Chikara, Fullana Torregrosa, Esteban, Fusayasu, Takahiro, Fuster Verdu, Juan, Gabrielli, Alessandro, Gabrielli, Andrea, Gadatsch, Stefan, Gadow, Paul Philipp, Gagliardi, Guido, Gagnon, Louis-Guillaume, Gallardo, Gabriel, Gallas, Elizabeth, Gallop, Bruce Joseph, Gamboa Goni, Rodrigo, Gan, Kock Kiam, Ganguly, Sanmay, Gao, Jun, Gao, Yanyan, Gao, Yongsheng, Garay Walls, Francisca, Garcia, Carmen, Garcia Navarro, Jose Enrique, Garcia Pascual, Juan Antonio, Garcia, Juanan, Garcia Argos, Carlos, Garcia-Sciveres, Maurice, Gardner, Robert William, Garelli, Nicoletta, Gargiulo, Simona, Garner, Christopher Andrew, Garonne, Vincent, Gasiorowski, Sean Joseph, Do Nascimento Gaspar, Philipp, Gaudiello, Andrea, Gaudio, Gabriella, Gauzzi, Paolo, Gavrilenko, Igor, Gavriliuk, Aleksandr, Gay, Colin Warren, Gaycken, Goetz, Gazis, Evangelos, Geanta, Andrei Alexandru, Gee, Carolyn, Gee, C.N. P., Geisen, Jannik, Geisen, Marc, Gemme, Claudia, Genest, Marie-Helene, Geng, Cong, Gentile, Simonetta, George, Simon, Geralis, Theodoros, Gerlach, Lino Oscar, Gessinger-Befurt, Paul, Gessner, Gregor, Ghasemi Bostanabad, Meisam, Ghneimat, Mazuza, Ghosh, Aishik, Ghosh, Anindya, Giacobbe, Benedetto, Giagu, Stefano, Giangiacomi, Nico, Giannetti, Paola, Giannini, Antonio, Giannini, Giulia, Gibson, Stephen, Gignac, Matthew, Gil, Damian Tomasz, Gilbert, Benjamin Jacob, Gillberg, Dag, Gilles, Geoffrey, Gillwald, N.E. K., Gingrich, Douglas, Giordani, Mario, Gingrich, Doug, Giordani, Mapo, Giraud, Pierre-Francois, Giugliarelli, Gilberto, Giugni, Danilo, Giuli, Francesco, Gkaitatzis, Stamatios, Gkialas, Ioannis, Gkougkousis, Evangelos Leonidas, Gkougkousis, Vagelis, Gkountoumis, Panagiotis, Gladilin, Leonid, Glasman, Claudia, Glatzer, Julian, Glaysher, P.C. F., Glazov, Alexander, Gledhill, Galen Rhodes, Gnesi, Ivan, Goblirsch-Kolb, Maximilian Emanuel, Godin, Dominique, Goldfarb, Steven, Golling, Tobias, Golubkov, Dmitry, da Silva Gomes, Agostinho, Goncalves Gama, Rafael, Morais Silva Goncalo, Ricardo Jose, Gonella, Giulia, Gonella, Laura, Gongadze, Alexi, Gonnella, Francesco, Gonski, Julia Lynne, Gonzalez de la Hoz, Santiago, Gonzalez Fernandez, Sergio, Gonzalez Lopez, Ricardo, Gonzalez Renteria, Cesar, Gonzalez Suarez, Rebeca, Gonzalez Sevilla, Sergio, Gonzalvo Rodriguez, Galo Rafael, Goossens, Luc, Gorasia, Nandish Arjan, Gorbounov, Petr, Gordon, Howard, Gorini, Benedetto, Gorini, Edoardo, Gorisek, Andrej, Goshaw, Alfred Thomas, Goshaw, A.T., Gostkin, Mikhail, Gottardo, Carlo Alberto, Gouighri, Mohamed, Goussiou, Anna, Govender, Nicolin, Goy, Corinne, Grabowska-Bold, Iwona, Graham, Emily Charlotte, Gramling, Johanna, Gramstad, Eirik, Grancagnolo, Sergio, Grandi, Mario, Grachev, Vadim, Gravila, Paul, Gravili, Francesco Giuseppe, Gray, Chloe, Gray, Heather, Grefe, Christian, Gregersen, Kristian Damlund, Gregor, Ingrid, Grenier, Philippe, Grevtsov, Kirill, Grieco, Chiara, Grieser, Nathan Allen, Grillo, Alex, Grimm, Kathryn, Grinstein, Sebastian, Grivaz, Jean-Francois, Groh, Sabrina, Gross, Eilam, Grosse-Knetter, Joern, Grout, Zara Jane, Grud, Christopher Ryan, Grummer, Aidan, Grundy, James Cameron, Guan, Liang, Guan, Wen, Gubbels, Christopher, Hance, Michael, Gubbels, Chris, Guenther, Jaroslav, Guerguichon, Antinea, Rojas, J.G. R.Guerrero, Guescini, Francesco, Guest, Daniel Hay, Guest, Dan, Gugel, Ralf, Guida, Alessandro, Guillemin, Thibault, Guindon, Stefan, Guo, Jun, Guo, Wen, Guo, Yicheng, Guo, Ziyu, Gupta, Ruchi, Gurbuz, Saime, Gustavino, Giuliano, Guth, Manuel, Gutierrez, Phillip, Gutschow, Christian, Guyot, Claude, Gwenlan, Claire, Gwilliam, Carl, Haaland, Even Simonsen, Haas, Andrew, Haber, Carl, Hadavand, Haleh, Hadef, Asma, Haleem, Mahsana, Haley, Joseph, Hall, Jack Joseph, Halladjian, Garabed, Hallewell, Gregory, Hamano, Kenji, Hamdaoui, Hassane, Hamer, Matthias, Hamity, Guillermo Nicolas, Han, Kunlin, Han, Liangliang, Han, Liang, Han, Shuo, Han, Yi Fei, Hanagaki, Kazunori, Hawkes, Christopher, Hays, Christopher Paul, Hance, Mike, Handl, David Michael, Hank, Michael Donald, Hankache, Robert, Hansen, Eva Brottmann, Hansen, Jorgen Beck, Hansen, Dines, Hansen, Maike Christina, Hansen, Peter, Hanson, Emily Claire, Hara, Kazuhiko, Harenberg, Torsten, Harkusha, Siarhei, Harrison, Paul Fraser, Hartman, Nicole Michelle, Hartmann, Nikolai, Hasegawa, Yoji, Hasib, Ahmed, Hassani, Samira, Haug, Sigve, Hauser, Reiner, Havranek, Miroslav, Hawkes, Chris, Hawkings, Richard, Hayashida, Shota, Hayden, Daniel, Hayes, Christopher Robyn, Hayes, Robin, Hays, Chris, Hays, Jonathan, Hayward, Helen, Haywood, Stephen, He, Fudong, He, Yunjian, Heath, Matthew Peter, Hedberg, Vincent, Heggelund, Andreas Lokken, Hehir, Natasha, Heidegger, Constantin, Heidegger, Kim Katrin, Heidorn, William Dale, Heilman, Jesse Alan, Heim, Sarah, Heim, Timon, Heinemann, Beate, Heinlein, James Geddy, Heinrich, Jochen Jens, Heinrich, Lukas Alexander, Hejbal, Jiri, Helary, Louis, Held, Alexander, Hellesund, Simen, Helling, Cole Michael, Hellman, Sten, Helsens, Clement, Henderson, R.C. W., Henkelmann, Lars, Henriques Correia, Ana Maria, Herde, Hannah Elizabeth, Hernandez Jimenez, Yesenia, Herr, Holger Arnold, Herrmann, Maximilian Georg, Herrmann, Tim, Herten, Gregor, Hertenberger, Ralf, Hervas, Luis, Herwig, Christian, Hesketh, Gavin, Hessey, Nigel, Hibi, Hiroaki, Higashino, Satoshi, Higon-Rodriguez, Emilio, Hildebrand, Kevin, Hill, John, Hill, Kurt Keys, Hiller, Karlheinz, Hillier, Stephen, Hils, Maximilian, Hinchliffe, Ian, Hinterkeuser, Florian, Hirose, Minoru, Hirose, Shigeki, Hirschbuehl, Dominic, Hiti, Bojan, Hladik, Ondrej, Hobbs, John David, Hobincu, Radu, Tal Hod, Noam, Hodgkinson, Mark, Hoecker, Andreas, Hohn, David, Hohov, Dmytro, Holm, Tanja, Holmes, Tova, Holzbock, Michael, Hommels, L.B. A.H., Hong, Tae Min, Honig, Jan Cedric, Honle, Andreas, Hooberman, Benjamin Henry, Hopkins, Walter, Horii, Yasuyuki, Horn, Philipp, Horyn, Lesya Anna, Hou, Suen, Hoummada, Abdeslam, Howarth, James William, Hoya, Joaquin, Hrabovsky, Miroslav, Hrivnac, Julius, Hrynevich, Aliaksei, Hrynova, Tetiana, Hsu, Pai-Hsien, Hsu, Shih-Chieh, Hu, Qipeng, Hu, Shuyang, Hu, Yifan, Huang, Danping, Huang, Xiaozhong, Huang, Yicong, Huang, Yanping, Hubacek, Zdenek, Hubaut, Fabrice, Hubner, Michael, Huegging, Fabian, Huffman, Todd Brian, Huhtinen, Mika, Hulsken, Raphael, Hunter, Robert Francis, Huseynov, Nazim, Huston, Joey, Huth, John, Hyneman, Rachel Jordan, Hyrych, Sofiia, Iacobucci, Giuseppe, Iakovidis, Georgios, Iakovidis, George, Ibragimov, Iskander, Iconomidou-Fayard, Lydia, Iengo, Paolo, Ignazzi, Rosanna, Iguchi, Ryunosuke, Iizawa, Tomoya, Ikegami, Yoichi, Ikeno, Masahiro, Ilic, Nikolina, Iltzsche, Franziska, Imam, Hajar, Introzzi, Gianluca, Iodice, Mauro, Iordanidou, Kalliopi, Ippolito, Valerio, Isacson, Max Fredrik, Ishino, Masaya, Islam, Wasikul, Issever, Cigdem, Istin, Serhat, Ponce, J.M. Iturbe, Iuppa, Roberto, Ivina, Anna, Izen, Joseph Michael, Izzo, Vincenzo, Jacka, Petr, Jackson, Paul, Jacobs, Ruth Magdalena, Jaeger, Benjamin Paul, Jain, Vivek, Jakel, Gunnar, Jakobi, Katharina Bianca, Jakobs, Karl, Jakoubek, Tomas, Jamieson, Jonathan, Janas, Krzysztof, Jansky, Roland, Janus, Michel, Janus, Piotr Andrzej, Jarlskog, Goran, Jaspan, Adam Elliott, Javadov, Namig, Javurek, Tomas, Javurkova, Martina, Jeanneau, Fabien, Jeanty, Laura, Jejelava, Juansher, Jenni, Peter, Jeong, Namgyun, Jezequel, Stephane, Jia, Jiangyong, Jia, Zihang, Jiang, Hai, Jiang, Yi, Jiang, Zihao, Jiggins, Stephen, Jimenez Morales, Fabricio Andres, Jimenez Pena, Javier, Jin, Shan, Jinaru, Adam, Jinnouchi, Osamu, Jivan, Harshna, Johansson, Per Daniel Conny, Johns, Kenneth, Johnson, Christian, Jones, Eleanor, Jones, R.W. L., Jones, Samuel David, Jones, Timothy John, Jones, T.J., Jovicevic, Jelena, Ju, Xiangyang, Junggeburth, Johannes Josef, Juste Rozas, Aurelio, Kaczmarska, Anna, Kado, Marumi, Kagan, Harris, Kagan, Michael Aaron, Kahn, Alan Mathew, Kahra, Christian, Kaji, Toshiaki, Kajomovitz Must, Enrique, Kalderon, Charles William, Kartvelishvili, Vakhtang, Kastanas, Konstantinos, Kalderon, Will, Kaluza, Adam, Kamenshchikov, Andrey, Kaneda, Michiru, Kang, Nathan Jihoon, Kang, Shuaiyan, Kano, Yuya, Kanzaki, Junichi, Kaplan, Laser Seymour, Kar, Deepak, Karava, Kla, Kareem, Mohammad, Karkanias, Ioannis, Karpov, Sergey, Karpova, Zoya, Kartvelishvili, Vato, Karyukhin, Andrei, Kasimi, Eirini, Kastanas, Alex, Kato, Chikuma, Katzy, Judith, Kawade, Kentaro, Kawagoe, Kiyotomo, Kawaguchi, Tomomi, Kawamoto, Tatsuo, Kawamura, Gen, Kay, Ellis, Kaya, Fikriye Idil, Kaya, Colette, Kazakos, Stergios, Kazanin, Vassili, Keaveney, James Michael, Keeler, Richard, Keller, John Stakely, Kellermann, Edgar, Kelsey, Daniel Christopher, Kempster, Jacob Julian, Kendrick, James Andrew, Kennedy, Kiley Elizabeth, Kepka, Oldrich, Kersten, Susanne, Kersevan, Borut Paul, Haghighat, S.Ketabchi, Khalil-Zada, Farhad, Khandoga, Mykola, Khanov, Alexander, Kharlamov, Alexey, Kharlamova, Tatyana, Khoda, Elham E, Khoo, Teng Jian, Khoriauli, Gia, Khramov, Evgeny, Khubua, J., Khubua, Djemal, Kido, Shogo, Kiehn, Moritz, Kim, Eunchong, Kim, Young-Kee, Kimura, Naoki, Kirchhoff, Andreas, Kirchmeier, David, Kirk, Julie, Kiryunin, Andrei, Kishimoto, Tomoe, Kisliuk, Dylan Perry, Kitali, Vincent, Kitsaki, Chara, Kivernyk, Oleh, Klapdor-Kleingrothaus, Thorwald, Klassen, Martin, Klein, Christoph Thomas, Klein, Matthew Henry, Klein, Max, Klein, Uta, Kleinknecht, Konrad, Klimek, Pawel Jan, Klimentov, Alexei, Klimpel, Fabian, Klingl, Tobias, Klioutchnikova, Tatiana, Klitzner, Felix Fidelio, Kluit, Peter, Kluth, Stefan, Kneringer, Emmerich, Knoops, E.B. F.G., Knue, Andrea Helen, Kobayashi, Dai, Kobel, Michael, Kocian, Martin, Kodama, Takafumi, Kodys, Peter, Koeck, D.M., Kock, Daniela, Konig, Philipp, Koffas, Thomas, Koehler, Nicolas, Kolb, Mathis, Koletsou, Iro, Komarek, Tomas, Kondo, Takahiko, Kordas, Konstantinos, Kondo, Taka, Koeneke, Karsten, Kong, A.X. Y., Konig, Adriaan Clemens, Kono, Takanori, Konstantinides, Vasilis, Konstantinidis, Nikolaos, Konya, Balazs, Kopeliansky, Revital, Koperny, Stefan Zenon, Korcyl, Krzysztof Marian, Kordas, Kostas, Koren, Guy, Korn, Andreas, Korolkov, Ilya, Korolkova, Elena, Korotkova, Natalia, Kortner, Oliver, Kortner, Sandra, Kostyukhin, Vadim, Kotsokechagia, Anastasia, Kotwal, Ashutosh, Koulouris, Aimilianos, Kourkoumeli-Charalampidi, Athina, Kourkoumelis, Christine, Kourlitis, Evangelos, Kouskoura, Vasiliki, Kowalewski, Robert Victor, Kowalewski, Bob, Kozanecki, Witold, Kozhin, Anatoli, Kramarenko, Viktor, Kramberger, Gregor, Krasnopevtsev, Dimitrii, Krasny, Mieczyslaw, Krasznahorkay, Attila, Krauss, Dominik, Kremer, Jakub, Kretzschmar, Jan, Kreul, Ken Matthias, Krieger, Peter, Krieter, Ferdinand, Krishnamurthy, Samyukta, Krishnan, Anjali, Krivos, Martin, Krizka, Karol, Kroeninger, Kevin Alexander, Kroha, Hubert, Kroll, Jiri, Kroll, Joseph Ira, Krowpman, Kyle Stuart, Kruchonak, Uladzimir, Krueger, Hans, Krumnack, Nils Erik, Kruse, Mark, Krzysiak, Janina Anna, Kubota, Arisa, Kuchinskaia, Olesia, Kuday, Sinan, Kuchler, Daniela, Kuechler, J.T., Kuehn, Susanne, Kuhl, Thorsten, Kukhtin, Victor, Kulchitsky, Y., Koultchitski, Iouri, Kuleshov, Sergey, Koultchitski, Yuri, Kuleshov, Serguei, Kulinich, Yakov Petrovich, Kuna, Marine, Kupco, Alexander, Kupfer, Tobias, Kuprash, Oleg, Kurashige, Hisaya, Kurchaninov, Leonid, Kurochkin, Yurii, Kurova, Anastasia, Kurth, Matthew Glenn, Kuwertz, Emma Sian, Kuze, Masahiro, Kvam, Audrey Katherine, Kvita, Jiri, Kwan, Tony, Lacasta Llacer, Carlos, Lacava, Francesco, Lack, David Philip John, Lacker, Heiko Markus, Lacour, Didier, Ladygin, Evgeny, Lai, Stanley Tsai-Ting, Ladygin, Evgueni, Lafaye, Remi, Laforge, Bertrand, Lagouri, Theodota, Lai, Stan, Lakomiec, Inga Katarzyna, Lambert, Joseph Earl, Lammers, Sabine Wedam, Lampl, Walter, Lampoudis, Christos, Lancon, Eric Christian, Landgraf, Ulrich, Landon, Murrough, Lang, Valerie, Lange, Joern, Langenberg, Robert Johannes, Lankford, Andrew James, Lanni, Francesco, Lantzsch, Kerstin, Lanza, Agostino, Lapertosa, Alessandro, Laporte, Jean-Francois, Lari, Tommaso, Lasagni Manghi, Federico, Lassnig, Mario, Latonova, Vera, Lau, Tak Shun, Laudrain, Antoine, Laurier, Alexandre, Lavorgna, Marco, Lawlor, Sean Dean, Lazzaroni, Massimo, Le, Brian, Le Guirriec, Emmanuel, Lebedev, Alexandre, Lecompte, T., Leblanc, Matthew Edgar, Le Compte, Thomas Joseph, Leblanc, Matt, Le Compte, Tom, Ledroit-Guillon, F., Lee, Ava Chloe Audrey, Lee, Claire, Lee, Graham Richard, Lee, Lawrence, Lee, Shih-Chang, Lee, Songkyo, Lefebvre, Benoit, Lefebvre, Helena, Lefebvre, Michel, Leggett, Charles, Lehmann, Konstantin, Lehmann, Niklaus, Lehmann Miotto, Giovanna, Leight, William Axel, Leisos, Antonios, Lisboa Leite, Marco, Leitgeb, Clara Elisabeth, Leitner, Rupert, Leney, Katharine, Lenz, Tatjana, Leone, Sandra, Leonidopoulos, Christos, Leopold, Alexander, Leroy, Claude, Les, Robert, Lester, Christopher, Levchenko, Mikhail, Leveque, Jessica, Levin, Daniel Sheldon, Lloyd, Stephen, Levin, Dan, Levinson, Lorne, Lewis, Daniel James, Li, Boyang, Li, Bing, Li, Changqiao, Li, Fan, Li, Heng, Li, Haifeng, Li, Jing, Li, Ke, Li, Liang, Li, Mengran, Li, Quanyin, Li, Shu, Li, Xingguo, Li, Yichen, Li, Zhi, Li, Zhiying, Li, Zhelun, Li, Zhiyuan, Liang, Zhijun, Liberatore, Marianna, Liberti, Barbara, Lie, Ki, Lim, Sanghoon, Lin, Chiao-Ying, Lin, Kuan-Yu, Linck, Rebecca, Lindley, Rachel Elizabeth, Lindon, Jack, Linss, Arthur, Lionti, Anthony, Lipeles, Elliot, Lipniacka, Anna, Liss, Anthony Michael, Lister, Alison, Little, Jared, Liu, Bo, Liu, Bingxuan, Liu, Hongbin, Liu, Jianbei, Liu, J.K. K., Liu, Kun, Liu, Minghui, Liu, Mingyi, Liu, Peilian, Liu, Xiaotian, Liu, Yi, Liu, Yang, Liu, Yanlin, Liu, Yanwen, Livan, Michele, Lleres, Annick, Llorente Merino, Javier, Luehring, Frederick, Lloyd, Steve, Lo, Cheuk Yee, Lobodzinska, Ewelina Maria, Loch, Peter, Loffredo, Salvatore, Lohse, Thomas, Lohwasser, Kristin, Lokajicek, Milos, Long, Jonathan, Long, Robin Eamonn, Longarini, Iacopo, Longo, Luigi, Lopez Paz, Ivan, Lopez Solis, Alvaro, Lorenz, Jeanette Miriam, Lorenzo Martinez, Narei, Lory, Alexander, Loesle, Alena, Lou, Xuanhong, Lou, Xinchou, Lounis, Abdenour, Love, Jeremy Robert, Love, Peter, Lozano Bahilo, Julio, Lu, Miaoran, Lu, Yun-Ju, Lubatti, Henry, Luci, Claudio, Lucio Alves, Fabio Lucio, Lucotte, Arnaud, Luehring, Fred, Luise, Ilaria, Luminari, Lamberto, Lund-Jensen, Bengt, Luongo, Nicholas, Lutz, Margaret Susan, Lynn, David, Lyons, Harry John, Lysak, Roman, Lytken, Else, Lyu, Feng, Lyubushkin, Vladimir, Lyubushkina, Tatiana, Ma, Hong, Ma, Lianliang, Ma, Yanhui, Donell, D.M. Mac, Macdonell, Danika Marina, Maccarrone, Giovanni, Macdonald, Calum Michael, Macdonald, Jack, Machado Miguens, Joana, Madar, Romain, Mader, Wolfgang, Madugoda Ralalage Don, Madhuranga, Madysa, Nico, Maeda, Junpei, Maeno, Tadashi, Maerker, Max, Magerl, Veronika, Magini, Nicolo, Magro, Jacopo, Mahon, Devin, Maidantchik, Carmen, Maio, Amelia, Maj, Klaudia, Majersky, Oliver, Majewski, Stephanie, Makida, Yasuhiro, Makovec, Nikola, Malaescu, Bogdan, Malecki, Pa., Malecki, Pawel, Maleev, Victor, Malek, Fairouz, Malito, Davide, Mallik, Usha, Malone, Claire, Maltezos, Stavros, Malyukov, Sergey, Mamuzic, Judita, Mancini, Giada, Mandalia, Jesal, Mandic, Igor, Manhaes de Andrade Filho, Luciano, Maniatis, Ioannis Michail, Ramos, J.Manjarres, Mankinen, Katja Hannele, Mann, Alexander, Manousos, Athanasios, Marshall, Zachary Louis, Martin, Timothy, Maslennikov, Aleksei, Mcfayden, Joshua Angus, Manousos, Thanos, Mansoulie, Bruno, Manthos, Ioannis, Manzoni, Stefano, Marantis, Alexandros, Marceca, Gino, Marchese, Luigi, Marchiori, Giovanni, Marcisovsky, Michal, Marcoccia, Lorenzo, Marcon, Caterina, Marjanovic, Marija, Mc Kay, Madalyn Ann, Mcpherson, Robert Anthony, Marshall, Zach, Martensson, M.U. F., Marti I Garcia, Salvador, Martin, Christopher Blake, Martin, Tim, Martin, Victoria, Martin Dit Latour, Bertrand, Martinelli, Luca, Martinez-Perez, Mario, Martinez Agullo, Pablo, Martinez Outschoorn, Verena Ingrid, Martin-Haugh, Stewart, Martoiu, Sorin, Martyniuk, Alex Christopher, Marzin, Antoine, Maschek, Stefan Raimund, Masetti, Lucia, Mashimo, Tetsuro, Mashinistov, Ruslan, Masik, Jiri, Maslennikov, Alexei, Massa, Lorenzo, Massarotti, Paolo, Mastrandrea, Paolo, Mastroberardino, Anna, Masubuchi, Tatsuya, Matakias, Dimitrios, Matic, Andrea, Matsuzawa, Nobuo, Mattig, Peter, Maurer, Julien, Macek, Bostjan, Maximov, Dmitriy, Mazini, Rachid, Maznas, Ioannis, Mazza, Simone Michele, Mc Gowan, John Patrick, Mc Kee, Shawn, Mccarthy, Thomas, Mccormack, William Patrick, Mcdonald, Emily Frances, Mcdonald, Millie, Mcdougall, Ashley Ellen, Mcfayden, Josh, Mchedlidze, Gvantsa, Mc Kay, Maddie, Mclean, Kayla, Mcmahon, Stephen, Mcnamara, Peter Charles, Mcnicol, Christopher John, Mcpherson, R.A., Mdhluli, Joyful Elma, Meadows, Zachary Alden, Meehan, Samuel Ross, Megy, Theo, Mehlhase, Sascha, Mehta, Andrew, Meirose, Bernhard, Melini, Davide, Mellado Garcia, Bruce, Mellenthin, Johannes, Melo, Matej, Meloni, Federico, Melzer, Alexander, Gouveia, E.D. Mendes, Mendes Jacques da Costa, Antonio Manuel, Meng, Huan Yu, Meng, Lingxin, Meng, Xiangting, Menke, Sven, Meoni, Evelin, Mergelmeyer, Sebastian, Merkt, Sebastian Andreas, Merlassino, Claudia, Mermod, Philippe, Merola, Leonardo, Meroni, Chiara, Merz, Garrett William, Meshkov, Oleg, Meshreki, John Kamal Rizk, Metcalfe, Jessica, Mete, Alaettin Serhan, Meyer, Christopher John, Meyer, Jean-Pierre, Michetti, Michele, Middleton, Robin, Mijovic, Liza, Mikenberg, George, Mikestikova, Marcela, Mikuz, Marko, Mildner, Hannes, Milic, Adriana, Milke, Christopher Don, Milke, Chris, Miller, David, Miller, Laura Stephanie, Milov, Alexander, Milstead, David Anthony, Minaenko, Andrei, Minashvili, Irakli, Mince, Laurynas, Mincer, Allen Irving, Mindur, Bartosz, Mineev, Mikhail, Minegishi, Yuji, Mino, Yuya, Mir Martinez, Lluisa Maria, Mironova, Maria, Mistry, Khilesh Pradip, Mitani, Takashi, Mitrevski, Jovan, Mitsou, Vasiliki, Mittal, Monika, Miu, Ovidiu, Miucci, Antonio, Miyagawa, Paul, Mizukami, Atsushi, Mjoernmark, Jan-Ulf, Mkrtchyan, Tigran, Mlynarikova, Michaela, Moa, Torbjorn, Mobius, Silke, Mochizuki, Kazuya, Moder, Paul, Mogg, Philipp, Mohapatra, Soumya, Moles Valls, Regina, Monig, Klaus, Monnier, Emmanuel, Montalbano, Alyssa Rae, Montejo Berlingen, Javier, Montella, Marco, Monticelli, Fernando, Monzani, Simone, Morange, Nicolas, Moreira de Carvalho, Ana Luisa, Moreno Lopez, Deywis, Moreno Llacer, Maria, Moreno Martinez, Carlos, Morettini, Paolo, Morgenstern, Marcus Matthias, Morgenstern, Stefanie, Mori, Daniel, Morii, Masahiro, Morinaga, Masahiro, Morisbak, Vanja, Morley, Anthony, Mornacchi, Giuseppe, Morris, Alice, Morvaj, Ljiljana, Moschovakos, Paraschos, Myers, Gregory William, Nachman, Benjamin Philip, Moschovakos, Paris, Moser, Brian, Mosidze, Maia, Moskalets, Tetiana, Moskvitina, Polina, Moss, Joshua, Moyse, E.J. W., Muanza, Steve, Mueller, James Alfred, Muller, Ralph, Muenstermann, Daniel, Mullier, Geoffrey, Mungo, Davide Pietro, Munoz Martinez, Jose Luis, Munoz Sanchez, Francisca, Murin, Pavel, Murray, William John, Murray, Bill, Murrone, Alessia, Muse, Joseph M, Muskinja, Miha, Mwewa, Chilufya, Myagkov, Alexei, Myers, Ava Anne, Neep, Thomas James, Ntekas, Konstantinos, Myers, Greg, Myers, John, Myska, Miroslav, Nachman, B.P., Nackenhorst, Olaf, Nag, Abhishek, Nagai, Koichi, Nagano, Kunihiro, Nagasaka, Yasushi, Nagle, James Lawrence, Nagy, Elemer, Nairz, Armin, Higuchi, Yu Nakahama, Nakamura, Koji, Nakamura, Tomoaki, Nanjo, Hajime, Napolitano, Fabrizio, Garcia, R.F. Naranjo, Narayan, Rohin Thampilali, Naryshkin, Iurii, Naseri, Mohsen, Naumann, Thomas, Navarro, Gabriela Alejandra, Nechaeva, Polina, Nechansky, Filip, Ng, Yan Wing, Neep, T.J., Negri, Andrea, Negrini, Matteo, Nellist, Clara, Nelson, Christina, Nelson, Michael Edward, Nemecek, Stanislav, Nessi, Marzio, Neubauer, Mark, Neuhaus, Friedemann, Neumann, Manuel, Newhouse, Robin, Newman, Paul Richard, Ng, Chi Wing, Nikolaidou, Rodanthi, Nilsson, Paal Nils Bertil, Ng, Sam Yanwing, Ng, Ying Wun Yvonne, Ngair, Badr-Eddine, Nguyen, Hoang Dai Nghia, Nguyen Manh, Tuan, Nibigira, Emery, Nickerson, Richard, Nikolaidou, Rosy, Nielsen, Daniel, Nielsen, Jason, Niemeyer, Marcel, Nikiforou, Nikiforos, Nikolaenko, Vladimir, Nikolic-Audit, I., Nikolopoulos, Konstantinos, Nilsson, Paul, Nindhito, Herjuno Rah, Nisati, Aleandro, Nishu, Nishu, Nisius, Richard, Nitsche, Isabel, Nitta, Tatsumi, Nobe, Takuya, Noel, Daniel Louis, Noguchi, Yohei, Nomidis, Ioannis, Nomura, Marcelo Ayumu, Nordberg, Markus, Novak, Jakob, Novak, Tadej, Novgorodova, Olga, Novotny, Radek, Nozka, Libor, Ntekas, Kostas, Nurse, Emily Laura, Oakham, Gerald, Ocariz, Jose Humberto, Ochi, Atsuhiko, Ochoa, Ines, Ochoa, Jean-Pierre, O'Connor, Kelsey Shea, Oda, Susumu, Odaka, Shigeru, Ordek, Serhat, Ogrodnik, Agnieszka Ewa, Oh, Alexander, Ohm, Christian, Oide, Hideyuki, Oishi, Reiyo, Ojeda, Martina Laura, Okawa, Hideki, Okazaki, Yuta, O'Keefe, Michael William, Okumura, Yasuyuki, Olariu, Albert, Seabra, L.F. Oleiro, Olivares, Sebastian, Oliveira Damazio, Denis, Oliver, Jason, Olsson, Mats Joakim Robert, Olszewski, Andrzej, Olszowska, Jolanta, Oncel, Omer Ogul, O'Neil, Dugan, O'Neill, Aaron Paul, Onofre, Antonio, Onyisi, P.U. E., Oppen, Henrik, Oreamuno Madriz, Rafael Guillermo, Oreglia, Mark, Orellana, Gonzalo Enrique, Orestano, Domizia, Orlando, Nicola, Orr, Robert, O'Shea, Valentine, Ouellette, Jeffrey Cortlandt, Parker, Andrew Michael, O'Shea, Val, Ospanov, Rustem, Otero y Garzon, Gustavo, Otono, Hidetoshi, Ott, Philipp Sebastian, Ottino, Gregory James, Ouchrif, Mohamed, Ouellette, Jeff, Ould-Saada, Farid, Ouraou, Ahmimed, Ouyang, Qun, Owen, Mark Andrew, Owen, Rhys, Ozcan, Erkcan, Ozturk, Nurcan, Pacalt, Josef, Pacey, Holly, Pachal, Katherine, Pacheco Pages, Andreu, Padilla Aranda, Cristobal, Pagan Griso, Simone, Palacino, Gabriel, Palazzo, Serena, Palestini, Sandro, Palka, Marek, Palni, Prabhakar, Pandini, Carlo Enrico, Panduro Vazquez, Jose Guillermo, Panduro Vazquez, William, Pani, Priscilla, Panizzo, Giancarlo, Paolozzi, Lorenzo, Papadatos, Constantine, Papageorgiou, Konstantinos, Parajuli, Santosh, Paramonov, Alexander, Paraskevopoulos, Christos, Paredes Hernandez, Daniela Katherinne, Paredes Saenz, Santiago Rafael, Parida, Bibhuti, Park, Tae Hyoun, Parker, Adam Jackson, Pollard, Christopher Samuel, Parker, Andy, Parodi, Fabrizio, Parrish, Elliot, Parsons, John, Parzefall, Ulrich, Pascual Dominguez, Luis, Pascuzzi, Vincent, Pasner, Jacob Martin, Pasquali, Federica, Pasqualucci, Enrico, Passaggio, Stefano, Pastore, Francesca, Pasuwan, Patrawan, Pataraia, Sophio, Pater, Joleen, Pater, Jo, Pathak, Atanu, Patton, Joseph, Pauly, Thilo, Pearkes, Jannicke Andree, Pedersen, Maiken, Pedraza Diaz, Lucia, Costa Batalha Pedro, Rute, Peiffer, Thomas, Peleganchuk, Sergey, Penc, Ondrej, Peng, Chen, Peng, Haiping, Sotto-Maior Peralva, Bernardo, Perego, Marta Maria, Pereira Peixoto, A.P., Pereira Sanchez, Laura, Perepelitsa, Dennis, Perez Codina, Estel, Perini, Laura, Pernegger, Heinz, Perrella, Sabrina, Perrevoort, Ann-Kathrin, Peters, Krisztian, Peters, Reinhild, Petersen, Brian, Petersen, Troels, Petit, Elisabeth, Petousis, Vlasios, Petridou, Chariclia, Petrucci, Fabrizio, Pettee, 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L., Lasagni Manghi , F, Massa , L., Vittori , C., Alfonsi , F, Cabras , G., Cervelli , A., Negrini , M., Todome , K., Carratta , G., Cavalli , N., Clissa , L., ATLAS collaboration, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Aad, G. 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W., Shaked Renous, D., Shan, L. Y., Shapiro, M., Sharma, A., Sharma, A. S., Shatalov, P. B., Shaw, K., Shaw, S. M., Shehade, M., Shen, Y., Sherman, A. D., Sherwood, P., Shi, L., Shimmin, C. O., Shimogama, Y., Shimojima, M., Shinner, J. D., Shipsey, I. P. J., Shirabe, S., Shiyakova, M., Shlomi, J., Shmeleva, A., Shochet, M. J., Shojaii, J., Shope, D. R., Shrestha, S., Shrif, E. M., Shroff, M. J., Shulga, E., Sicho, P., Sickles, A. M., Sideras Haddad, E., Sidiropoulou, O., Sidoti, A., Siegert, F., Sijacki, Dj., Silva, M., Silva Oliveira, M. V., Silverstein, S. B., Simion, S., Simoniello, R., Simpson-allsop, C. J., Simsek, S., Sinervo, P., Sinetckii, V., Singh, S., Sioli, M., Siral, I., Sivoklokov, S. Yu., Sjölin, J., Skaf, A., Skorda, E., Skubic, P., Slawinska, M., Sliwa, K., Smakhtin, V., Smart, B. H., Smiesko, J., Smirnov, N., Smirnov, S. Yu., Smirnov, Y., Smirnova, L. N., Smirnova, O., Smith, E. A., Smith, H. A., Smizanska, M., Smolek, K., Smykiewicz, A., Snesarev, A. A., Snoek, H. L., Snyder, I. M., Snyder, S., Sobie, R., Soffer, A., Søgaard, A., Sohns, F., Solans Sanchez, C. A., Soldatov, E. Yu., Soldevila, U., Solodkov, A. A., Soloshenko, A., Solovyanov, O. V., Solovyev, V., Sommer, P., Son, H., Sonay, A., Song, W., Song, W. Y., Sopczak, A., Sopio, A. L., Sopkova, F., Sottocornola, S., Soualah, R., Soukharev, A. M., South, D., Spagnolo, S., Spalla, M., Spangenberg, M., Spanò, F., Sperlich, D., Spieker, T. M., Spigo, G., Spina, M., Spiteri, D. P., Spousta, M., Stabile, A., Stamas, B. L., Stamen, R., Stamenkovic, M., Stampekis, A., Stanecka, E., Stanislaus, B., Stanitzki, M. M., Stankaityte, M., Stapf, B., Starchenko, E. A., Stark, G. H., Stark, J., Staroba, P., Starovoitov, P., Stärz, S., Staszewski, R., Stavropoulos, G., Stegler, M., Steinberg, P., Steinhebel, A. L., Stelzer, B., Stelzer, H. J., Stelzer-Chilton, O., Stenzel, H., Stevenson, T. J., Stewart, G. A., Stockton, M. C., Stoicea, G., Stolarski, M., Stonjek, S., Straessner, A., Strandberg, J., Strandberg, S., Strauss, M., Strebler, T., Strizenec, P., Ströhmer, R., Strom, D. M., Stroynowski, R., Strubig, A., Stucci, S. A., Stugu, B., Stupak, J., Styles, N. A., Su, D., Su, W., Su, X., Suarez, N. B., Sulin, V. V., Sullivan, M. J., Sultan, D. M. S., Sultansoy, S., Sumida, T., Sun, S., Sun, X., Suster, C. J. E., Sutton, M. R., Suzuki, S., Svatos, M., Swiatlowski, M., Swift, S. P., Swirski, T., Sydorenko, A., Sykora, I., Sykora, M., Sykora, T., Ta, D., Tackmann, K., Taenzer, J., Taffard, A., Tafirout, R., Tagiev, E., Taibah, R. H. M., Takashima, R., Takeda, K., Takeshita, T., Takeva, E. P., Takubo, Y., Talby, M., Talyshev, A. A., Tam, K. C., Tamir, N. M., Tanaka, J., Tanaka, R., Tapia Araya, S., Tapprogge, S., Tarek Abouelfadl Mohamed, A., Tarem, S., Tariq, K., Tarna, G., Tartarelli, G. F., Tas, P., Tasevsky, M., Tassi, E., Tateno, G., Tavares Delgado, A., Tayalati, Y., Taylor, A. J., Taylor, G. N., Taylor, W., Teagle, H., Tee, A. S., Teixeira De Lima, R., Teixeira-Dias, P., Ten Kate, H., Teoh, J. J., Terashi, K., Terron, J., Terzo, S., Testa, M., Teuscher, R. J., Thais, S. J., Themistokleous, N., Theveneaux-Pelzer, T., Thomas, D. W., Thomas, J. P., Thompson, E. A., Thompson, P. D., Thomson, E., Thorpe, E. J., Tikhomirov, V. O., Tikhonov, Yu. A., Timoshenko, S., Tipton, P., Tisserant, S., Todome, K., Todorova-Nova, S., Todt, S., Tojo, J., Tokár, S., Tokushuku, K., Tolley, E., Tombs, R., Tomiwa, K. G., Tomoto, M., Tompkins, L., Tornambe, P., Torrence, E., Torres, H., Torró Pastor, E., Toscani, M., Tosciri, C., Toth, J., Tovey, D. R., Traeet, A., Treado, C. J., Trefzger, T., Tresoldi, F., Tricoli, A., Trigger, I. M., Trincaz-Duvoid, S., Trischuk, D. A., Trischuk, W., Trocmé, B., Trofymov, A., Troncon, C., Trovato, F., Truong, L., Trzebinski, M., Trzupek, A., Tsai, F., Tseng, J. C. -L., Tsiareshka, P. V., Tsirigotis, A., Tsiskaridze, V., Tskhadadze, E. G., Tsopoulou, M., Tsukerman, I. I., Tsulaia, V., Tsuno, S., Tsybychev, D., Tu, Y., Tudorache, A., Tudorache, V., Tuna, A. N., Turchikhin, S., Turgeman, D., Turk Cakir, I., Turner, R. J., Turra, R., Tuts, P. M., Tzamarias, S., Tzovara, E., Uchida, K., Ukegawa, F., Unal, G., Unal, M., Undrus, A., Unel, G., Ungaro, F. C., Unno, Y., Uno, K., Urban, J., Urquijo, P., Usai, G., Uysal, Z., Vacek, V., Vachon, B., Vadla, K. O. H., Vafeiadis, T., Vaidya, A., Valderanis, C., Valdes Santurio, E., Valente, M., Valentinetti, S., Valero, A., Valéry, L., Vallance, R. A., Vallier, A., Valls Ferrer, J. A., Van Daalen, T. R., Van Gemmeren, P., Van Stroud, S., Van Vulpen, I., Vanadia, M., Vandelli, W., Vandenbroucke, M., Vandewall, E. R., Vannicola, D., Vari, R., Varnes, E. W., Varni, C., Varol, T., Varouchas, D., Varvell, K. E., Vasile, M. E., Vasquez, G. A., Vazeille, F., Vazquez Furelos, D., Vazquez Schroeder, T., Veatch, J., Vecchio, V., Veen, M. J., Veloce, L. M., Veloso, F., Veneziano, S., Ventura, A., Verbytskyi, A., Vercesi, V., Verducci, M., Vergel Infante, C. M., Vergis, C., Verkerke, W., Vermeulen, A. T., Vermeulen, J. C., Vernieri, C., Verschuuren, P. J., Vetterli, M. C., Viaux Maira, N., Vickey, T., Vickey Boeriu, O. E., Viehhauser, G. H. A., Vigani, L., Villa, M., Villaplana Perez, M., Villhauer, E. M., Vilucchi, E., Vincter, M. G., Virdee, G. S., Vishwakarma, A., Vittori, C., Vivarelli, I., Vogel, M., Vokac, P., Von Ahnen, J., von Buddenbrock, S. E., Von Toerne, E., Vorobel, V., Vorobev, K., Vos, M., Vossebeld, J. H., Vozak, M., Vranjes, N., Vranjes Milosavljevic, M., Vrba, V., Vreeswijk, M., Vu, N. K., Vuillermet, R., Vukotic, I., Wada, S., Wagner, P., Wagner, W., Wagner-Kuhr, J., Wahdan, S., Wahlberg, H., Wakasa, R., Walbrecht, V. M., Walder, J., Walker, R., Walker, S. D., Walkowiak, W., Wallangen, V., Wang, A. M., Wang, A. Z., Wang, C., Wang, H., Wang, J., Wang, P., Wang, Q., Wang, R. -J., Wang, R., Wang, S. M., Wang, W. T., Wang, W., Wang, W. X., Wang, Y., Wang, Z., Wanotayaroj, C., Warburton, A., Ward, C. P., Ward, R. J., Warrack, N., Watson, A. T., Watson, M. F., Watts, G., Waugh, B. M., Webb, A. F., Weber, C., Weber, M. S., Weber, S. A., Weber, S. M., Wei, Y., Weidberg, A. R., Weingarten, J., Weirich, M., Weiser, C., Wells, P. S., Wenaus, T., Wendland, B., Wengler, T., Wenig, S., Wermes, N., Wessels, M., Weston, T. D., Whalen, K., Wharton, A. M., White, A. S., White, A., White, M. J., Whiteson, D., Whitmore, B. W., Wiedenmann, W., Wiel, C., Wielers, M., Wieseotte, N., Wiglesworth, C., Wiik-Fuchs, L. A. M., Wilkens, H. G., Wilkins, L. J., Williams, D. M., Williams, H. H., Williams, S., Willocq, S., Windischhofer, P. J., Wingerter-Seez, I., Winkels, E., Winklmeier, F., Winter, B. T., Wittgen, M., Wobisch, M., Wolf, A., Wölker, R., Wollrath, J., Wolter, M. W., Wolters, H., Wong, V. W. S., Wongel, A. F., Woods, N. L., Worm, S. D., Wosiek, B. K., Woźniak, K. W., Wraight, K., Wu, S. L., Wu, X., Wu, Y., Wuerzinger, J., Wyatt, T. R., Wynne, B. M., Xella, S., Xiang, J., Xiao, X., Xie, X., Xiotidis, I., Xu, D., Xu, H., Xu, L., Xu, R., Xu, T., Xu, W., Xu, Y., Xu, Z., Yabsley, B., Yacoob, S., Yallup, D. P., Yamaguchi, N., Yamaguchi, Y., Yamamoto, A., Yamatani, M., Yamazaki, T., Yamazaki, Y., Yan, J., Yan, Z., Yang, H. J., Yang, H. T., Yang, S., Yang, T., Yang, X., Yang, Y., Yang, Z., Yao, W-M., Yap, Y. C., Ye, H., Ye, J., Ye, S., Yeletskikh, I., Yexley, M. R., Yigitbasi, E., Yin, P., Yorita, K., Yoshihara, K., Young, C. J. S., Young, C., Yu, J., Yuan, R., Yue, X., Zaazoua, M., Zabinski, B., Zacharis, G., Zaffaroni, E., Zahreddine, J., Zaitsev, A. M., Zakareishvili, T., Zakharchuk, N., Zambito, S., Zanzi, D., Zeißner, S. V., Zeitnitz, C., Zemaityte, G., Zeng, J. C., Zenin, O., Ženiš, T., Zerwas, D., Zgubič, M., Zhang, B., Zhang, D. F., Zhang, G., Zhang, J., Zhang, K., Zhang, L., Zhang, M., Zhang, R., Zhang, S., Zhang, X., Zhang, Y., Zhang, Z., Zhao, P., Zhao, Y., Zhao, Z., Zhemchugov, A., Zheng, Z., Zhong, D., Zhou, B., Zhou, C., Zhou, H., Zhou, M., Zhou, N., Zhou, Y., Zhu, C. G., Zhu, C., Zhu, H. L., Zhu, H., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zhulanov, V., Zieminska, D., Zimine, N. I., Zimmermann, S., Zinonos, Z., Ziolkowski, M., Živković, L., Zobernig, G., Zoccoli, A., Zoch, K., Zorbas, T. G., Zou, R., Zwalinski, L., Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Atlas, Collaboration, and Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2936
Subjects: electron, Top quark, Kjerne- og elementærpartikkelfysikk: 431 [VDP], Physics and Astronomy (miscellaneous), 13000 GeV-cms, measured [channel cross section], Parton, pair production [top], 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), Subatomic Physics, scattering [p p], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], parton, associated production [Z0], Nuclear Experiment, Settore FIS/01, Physics, Luminosity (scattering theory), Large Hadron Collider, 4. Education, ATLAS, 16. Peace & justice, Nuclear and elementary particle physics: 431 [VDP], CERN LHC Coll, medicine.anatomical_structure, kinematics, colliding beams [p p], top: pair production, channel cross section: measured, Particle Physics - Experiment, data analysis method, p p: scattering, Particle physics, Z boson, CERN Lab, Regular Article - Experimental Physics, 530 Physics, FOS: Physical sciences, LHC, ATLAS, High Energy Physics, differential cross section: measured, Cross section (physics), Atlas (anatomy), measured [differential cross section], muon, 0103 physical sciences, medicine, ddc:530, High Energy Physics, 010306 general physics, Engineering (miscellaneous), top quark, Muon, hep-ex, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Física, leptonic decay [Z0], Z0: associated production, Z0: leptonic decay, LHC, Particle Physics, Top physics, High Energy Physics::Experiment, Hadron-hadron collisions, p p: colliding beams, experimental results, Lepton
Abstract: We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Au CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANIstralia; BMWFW and FWF, Austria; ANAXS, Azerbaijan; SSTC, Belarus;D, Chile; CAS, MOST and NSFC, China; Minciencias, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; JINR; MESofRussia andNRCKI, Russian Federation; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOEandNSF, USA. In addition, individual groups andmembers have received support fromBCKDF, CANARIE, ComputeCanada, CRC and IVADO, Canada; Beijing Municipal Science & Technology Commission, China; COST, ERC, ERDF, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), theY Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in Ref. [91]., Measurements of both the inclusive and differential production cross sections of a top-quark-antiquark pair in association with a Z boson (t (t) over barZ) are presented. The measurements are performed by targeting final states with three or four isolated leptons (electrons or muons) and are based on root s = 13 TeV proton-proton collision data with an integrated luminosity of 139 fb(-1), recorded from 2015 to 2018 with the ATLAS detector at the CERN Large Hadron Collider. The inclusive cross section is measured to be a sigma(t (t) over barZ)= 0.99 +/- 0.05 (stat.) +/- 0.08 (syst.) pb, in agreement with the most precise theoretical predictions. The differential measurements are presented as a function of a number of kinematic variables which probe the kinematics of the t (t) over barZ system. Both absolute and normalised differential crosssection measurements are performed at particle and parton levels for specific fiducial volumes and are compared with theoretical predictions at different levels of precision, based on a chi(2)/ndf and p value computation. Overall, good agreement is observed between the unfolded data and the predictions., CERN, ANPCyT, YerPhI, Armenia, Australian Research Council, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Natural Sciences and Engineering Research Council of Canada (NSERC), NRC, Canada, Canada Foundation for Innovation, SSTC, Belarus, Ministry of Education, Youth & Sports - Czech Republic Czech Republic Government, Czech Republic Government, DNRF, Denmark, Danish Natural Science Research Council, Centre National de la Recherche Scientifique (CNRS), CEA-DRF/IRFU, France, SRNSFG, Georgia, Federal Ministry of Education & Research (BMBF), HGF, Germany, Max Planck Society, Greek Ministry of Development-GSRT, RGC, China, Hong Kong SAR, China, Israel Science Foundation, Benoziyo Center, Israel, Istituto Nazionale di Fisica Nucleare (INFN), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science, CNRST, Morocco, Netherlands Organization for Scientific Research (NWO) Netherlands Government, RCN, Norway, Ministry of Science and Higher Education, Poland, NCN, Poland, Portuguese Foundation for Science and Technology European Commission, MNE/IFA, Romania, JINR, MESofRussia, Russian Federation, Ministry of Education, Science & Technological Development, Serbia, MSSR, Slovakia, Slovenian Research Agency - Slovenia, MIZS, Slovenia, DST/NRF, South Africa, Spanish Government, SRC, Sweden, Wallenberg Foundation, Sweden, SERI, Switzerland, Swiss National Science Foundation (SNSF), Cantons of Bern and Geneva, Switzerland, Ministry of Science and Technology, Taiwan, Ministry of Energy & Natural Resources - Turkey, UK Research & Innovation (UKRI) Science & Technology Facilities Council (STFC), DOEandNSF, USA, BCKDF, Canada, CANARIE, Canada, ComputeCanada, Canada, CRC, Canada, IVADO, Canada, Beijing Municipal Science & Technology Commission, COST, France, ERC, France, ERDF, France, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union, France, French National Research Agency (ANR), German Research Foundation (DFG), Alexander von Humboldt Foundation, Thales Group, Aristeia programmes, EU-ESF, Greece, Greek NSRF, Greece, BSF-NSF, Israel, German-Israeli Foundation for Scientific Research and Development, La Caixa Banking Foundation, Spain, CERCA Programme Generalitat de Catalunya, Spain, GenT Programmes Generalitat Valenciana, Spain, Goran Gustafssons Stiftelse, Sweden, Royal Society of London, Leverhulme Trust, BMWFW, Austria, Austrian Science Fund (FWF), Azerbaijan National Academy of Sciences (ANAS), D, Chile, Minciencias, Colombia
Published: 2021
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41. Genomics Links Inflammation With Neurocognitive Impairment in Children Living With Human Immunodeficiency Virus Type-1

Author: George R. Seage, Kelly A. Frazer, Sharon Nichols, Stephen A. Spector, Jihoon Kim, Pratima Rawat, Rodney N. Trout, Russell B. Van Dyke, Paige L. Williams, Sean S Brummel, Kumud K. Singh, and Olivier Harismendy
Subjects: Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Inflammasomes, Neurocognitive Disorders, HIV Infections, Inflammation, Logistic regression, Receptors, CCR, Major Articles and Brief Reports, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Immunology and Allergy, Gene silencing, Child, Exome sequencing, Gene knockdown, business.industry, Intracellular Signaling Peptides and Proteins, Infant, Membrane Proteins, Genomics, Odds ratio, Infectious Disease Transmission, Vertical, 030104 developmental biology, Infectious Diseases, 14-3-3 Proteins, Child, Preschool, Cohort, HIV-1, Female, Microglia, medicine.symptom, business, Neurocognitive, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract: Background We identified host single-nucleotide variants (SNVs) associated with neurocognitive impairment (NCI) in perinatally HIV-infected (PHIV) children. Methods Whole-exome sequencing (WES) was performed on 217 PHIV with cognitive score for age (CSA) Results Twenty-nine SNVs in 24 genes reaching P ≤ .002 and OR ≥ 1.5 comparing CSA Conclusions Using WES and 2 VCs, and gene silencing of microglia we identified 3 genetic variants associated with NCI and inflammation in HIV-infected children.
Published: 2020
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42. von Willebrand factor to protein C ratio-related thrombogenicity with systemic inflammation is predictive of graft dysfunction after liver transplantation: Retrospective cohort study

Author: Hye-Mee Kwon, Youngjin Moon, Jihoon Park, Jun-Gol Song, Gyu-Sam Hwang, Junhyeop Jeong, Kyoung-Sun Kim, Ki-Hun Kim, and In-Gu Jun
Subjects: Adult, Male, Reoperation, medicine.medical_specialty, Exacerbation, medicine.drug_class, medicine.medical_treatment, Thrombogenicity, Liver transplantation, Systemic inflammation, 03 medical and health sciences, 0302 clinical medicine, Von Willebrand factor, Internal medicine, von Willebrand Factor, Living Donors, medicine, Humans, Transplantation, Homologous, Retrospective Studies, Inflammation, biology, business.industry, Anticoagulant, Thrombosis, Retrospective cohort study, General Medicine, Middle Aged, Liver Transplantation, C-Reactive Protein, 030220 oncology & carcinogenesis, biology.protein, Cardiology, Female, 030211 gastroenterology & hepatology, Surgery, medicine.symptom, business, Protein C, medicine.drug
Abstract: Introduction Early allograft dysfunction (EAD) is known to be a prototype of graft failure and ultimately influences long-term graft failure or death. We hypothesized that pretransplant thrombogenicity evaluated by procoagulant and anticoagulant, von Willebrand factor (vWF), factor Ⅷ (FⅧ), protein C (PC) and their imbalance ratio of vWF-to-PC (vWFPCR) and FVIII-to-PC (FⅧPCR), is associated with EAD and 90-day graft failure after living-related liver transplantation (LDLT) and contributes to further exacerbation of graft dysfunction when coexists with systemic inflammation. Material and methods Of 1199 prospectively registered LDLT patients, 698 with measurements of each thrombogenicity parameters were analyzed. Risk factors for EAD development were searched and subsequent best cut-offs was calculated according to the receiver operator characteristic curve analysis. When comparing the outcome, multivariable regression analysis and inverse probability of treatment weighting (IPTW) of the propensity score were performed. Results The prevalence of EAD was 10.7% (n = 75/698) after LDLT. Of parameters, vWFPCR had highest predictivity potential of EAD with the best cut-off of 8.06. The relationship between vWFPCR≥8.06 showed significant association with EAD development (OR [95%CI], 2.55[1.28–5.09], P = 0.008) and 90-day graft failure (HR [95%CI], 2.24 [1–4.98], P = 0.043) after IPTW-adjustment. Furthermore, risk of EAD increased proportionally with increasing C-reactive protein as a continuous metric of systemic inflammation, and more steeply in those with higher thrombogenicity (i.e., higher vWFPCR). Adding vWFPCR to MELD score improved EAD risk prediction by 21.9%. Conclusions Pretransplant thrombogenicity assessed by imbalance of pro- and anticoagulant, was significantly associated with EAD and 90-day graft failure after LDLT and this association was worsened by systemic inflammation.
Published: 2020
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43. Validation of the post-neoadjuvant staging system of the American joint committee on cancer, 8th edition, in patients treated with neoadjuvant chemoradiotherapy followed by curative esophagectomy for localized esophageal squamous cell carcinoma

Author: Ji Yong Ahn, Gin Hyug Lee, Jihoon Kang, Ho June Song, Jonghoon Kim, Do Hoon Kim, Jin-Sook Ryu, Kyung-Ja Cho, Hyeong Ryul Kim, Kee Don Choi, Han Pil Lee, Mi-Yeon Lee, Sung-Bae Kim, Sook Ryun Park, Yong-Hee Kim, and Hwoon-Yong Jung
Subjects: Adult, Male, Oncology, medicine.medical_specialty, Esophageal Neoplasms, Lymphovascular invasion, medicine.medical_treatment, Perineural invasion, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Neoadjuvant therapy, Survival analysis, Aged, Retrospective Studies, Tumor Regression Grade, business.industry, Chemoradiotherapy, Middle Aged, Esophageal cancer, Prognosis, medicine.disease, Combined Modality Therapy, Neoadjuvant Therapy, Esophagectomy, Survival Rate, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Surgery, Esophageal Squamous Cell Carcinoma, business, Follow-Up Studies
Abstract: The American Joint Committee on Cancer 8th edition staging system presents separate classifications for pTNM and post-neoadjuvant ypTNM (ypTNM-8th) to enhance prognostic prediction after neoadjuvant therapy and surgery. We aimed to validate the ypTNM-8th staging system and to compare the prognostication performance of ypTNM-8th with that of pTNM-7th and pTNM-8th in esophageal squamous cell carcinoma (ESCC) patients receiving neoadjuvant chemoradiotherapy (nCRT).We reviewed 207 ESCC patients treated with nCRT between January 2007 and December 2014 and compared the Akaike information criterion (AIC) and Harrell's C-index to determine the prognostic performance of each TNM system.Survival curve analysis of pTNM-7th and -8th showed a stepwise drop in survival from ypT0N0 to advanced stages, whereas the survival outcome of ypStage III showed a better prognosis than that of ypStage II according to ypTNM-8th. Lymphovascular invasion, perineural invasion, and tumor regression grade were significantly associated with overall survival on univariate analysis. Each TNM system showed significant p-values for trend (p 0.0001 each), but after adjusting for prognostic factors, ypTNM-8th did not significantly predict survival (p = 0.15), whereas pTNM-7th remained significant (p 0.001). pTNM-7th incorporating ypT0N0M0 and ypT0 (is)N + M0 as separate groups was superior in prognostication as its AIC was smaller and its C-index was higher than those of pTNM-8th and ypTNM-8th, respectively.Because ypTNM-8th did not provide sufficient prognostication for patients with ESCC treated with nCRT followed by esophagectomy, more sophisticated prognostic classification should be developed for the ypTNM staging system in these patients.
Published: 2020
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44. Radiographic Follow-Up of Fibrous Dysplasia in 138 Patients

Author: Doohyun Hwang, Jihoon Jeon, Ja Young Choi, Sung Hwan Hong, Hee Dong Chae, and Hye Jin Yoo
Subjects: Adult, Male, Adolescent, Radiography, Fibrous Dysplasia, Polyostotic, 030218 nuclear medicine & medical imaging, Lesion, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Temporal change, Child, Aged, Natural course, business.industry, Fibrous dysplasia, Extremities, General Medicine, Middle Aged, medicine.disease, Skeletal maturity, 030220 oncology & carcinogenesis, Disease Progression, Female, sense organs, medicine.symptom, Nuclear medicine, business, Fibrous Dysplasia, Monostotic, Follow-Up Studies, Calcification
Abstract: OBJECTIVE. The purpose of this study was to explore the temporal changes in fibrous dysplasia (FD) at radiographic follow-up. MATERIALS AND METHODS. A total of 138 patients with FD who had undergone extremity radiography at least twice with a minimum 12-month interval between examinations were enrolled in this study. FD was monostotic in 99 patients and polyostotic in 39 patients. Patients were also classified according to skeletal maturity as follows: Patients 16 years old or younger were classified in the skeletally immature group (n = 34), and patients 17 years old or older were classified in the skeletally mature group (n = 104). We compared the initial and follow-up radiographs for the following findings: lesion size, opacity, sclerotic rim, calcification, and trabeculation. RESULTS. Of the 138 patients, radiographic follow-up showed no change in lesion size in 101 patients (73.2%), progression in 31 (22.5%), and regression in six (4.3%). FD in immature bones progressed more often than FD in mature bones (23/34 [67.6%] vs 8/104 [7.7%], respectively; p = 0.000), and polyostotic FD had a greater chance of regressing than monostotic FD (4/39 [10.3%] vs 2/99 [2.0%]; p = 0.032). A temporal change in FD lesion opacity was noticed in a minority of patients (19/138, 13.8%). Variable changes were observed in the sclerotic rim, calcification, and trabeculation. CONCLUSION. The radiographic follow-up of FD showed that approximately a quarter of lesions changed in size over time. Regardless of the change in lesion size, opacity and several morphologic features of FD changed during the follow-up period, which might reflect the histopathologic evolution of FD.
Published: 2020
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45. Comparison among Three Different Steroid Therapies for Idiopathic Sudden Sensorineural Hearing Loss

Author: Myung Hoon Yoo, Kyu-Yup Lee, Da Jung Jung, and Jihoon Lee
Subjects: Pediatrics, medicine.medical_specialty, business.industry, medicine.medical_treatment, Steroid, 03 medical and health sciences, 0302 clinical medicine, Otorhinolaryngology, Sudden sensorineural hearing loss, medicine, Surgery, 030223 otorhinolaryngology, business, 030217 neurology & neurosurgery, Dexamethasone, medicine.drug
Abstract: Background and Objectives The optimal dose or type of systemic steroid for treating idiopathic sudden sensorineural hearing loss (ISSNHL) is unclear. Herein, we compare the efficacy of three steroid treatment protocols.Subjects and Method We reviewed the medical records of 140 adult ISSNHL patients from a tertiary medical center. The patients were divided into three groups based on their treatment regimen: Group 1 received intravenous 10 mg/day dexamethasone combined with intratympanic (IT) steroid injection, followed by prednisolone for 5 days after discharge; Group 2 received 10 mg/day dexamethasone for 5 days, followed by 5 mg/day for 5 days over a 10-day hospitalization period; and Group 3 received 10 mg/day dexamethasone combined with IT steroid injection during a 5-day hospital stay, followed by 5 mg/day dexamethasone for 5 days after discharge. The hearing thresholds were measured using an automatic audiometer at 0.5, 1, 2, 3, 4, and 8 kHz. Hearing recovery on Day 90 was categorized according to Siegel’s criteria.Results Univariate and multivariate analyses showed that patients in Group 3 had the lowest hearing thresholds, and the best results for speech reception threshold and speech discrimination scores. The impact of favorable thresholds in Group 3 was better among patients with a baseline average hearing threshold of ＜70 dB. Complete recovery was more likely in Group 3 than in the other groups, based on the odds ratios.Conclusion Administration of dexamethasone-based systemic steroid combined with IT steroid injection and a relatively long hospitalization period produced the most favorable result.
Published: 2020
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46. Next generation miRNA inhibition using short anti-seed PNAs encapsulated in PLGA nanoparticles

Author: Jihoon Lim, Frank J. Slack, Shipra Malik, Raman Bahal, and Demetrios T. Braddock
Subjects: Peptide Nucleic Acids, Pharmaceutical Science, Nanoparticle, 02 engineering and technology, Transfection, Article, Flow cytometry, law.invention, Mice, 03 medical and health sciences, chemistry.chemical_compound, Polylactic Acid-Polyglycolic Acid Copolymer, In vivo, Confocal microscopy, law, microRNA, medicine, Animals, Distribution (pharmacology), 030304 developmental biology, 0303 health sciences, medicine.diagnostic_test, technology, industry, and agriculture, 021001 nanoscience & nanotechnology, MicroRNAs, PLGA, chemistry, Biophysics, Nanoparticles, 0210 nano-technology
Abstract: Selective inhibition of microRNAs (miRNAs) offers a new avenue for cancer therapeutics. While most of the current anti-miRNA (antimiR) reagents target full length miRNAs, here we investigate novel nanoparticle-delivered short PNA probes containing cationic domains targeting the seed region of the miRNA for effective antimiR therapy. For proof of concept, we tested PNAs targeting miRNA-155 and employed poly(lactic-co-glycolic acid) (PLGA)-based nanoparticle formulation for delivery. A comprehensive evaluation of PLGA nanoparticles (NPs) containing short PNA probes showed significantly superior loading, release profile, and uniform size distribution, compared to conventional non-cationic PNA probes. Confocal microscopy and flow cytometry analyses showed efficient transfection efficiency and uniform distribution of PLGA NPs containing short PNA probes in the cytoplasm. Functional analysis also confirmed efficient miRNA-155 inhibition including an effect on its downstream target proteins. Further, reduced tumor growth was observed after systemic delivery of PLGA nanoparticles containing short PNA probes in vivo in a xenograft mouse model following inhibition of miR-155. There was no evidence of acute or chronic toxicity associated with systemic delivery of PLGA NPs containing short PNA probes in the mice. Overall, in this paper we present a novel antimiR strategy based on PLGA nanoparticle delivered short PNA probes for potential cancer therapy.
Published: 2020
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47. Mitochondrial diabetes and mitochondrial DNA mutation load in MELAS syndrome

Author: Jihoon Na, Young Mock Lee, Ho-Seong Kim, and Hyun Wook Chae
Subjects: Male, medicine.medical_specialty, Mitochondrial DNA, Adolescent, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, MELAS syndrome, DNA, Mitochondrial, Impaired glucose tolerance, 03 medical and health sciences, Diabetes mellitus genetics, 0302 clinical medicine, Endocrinology, Insulin resistance, Mitochondrial myopathy, Diabetes mellitus, Internal medicine, Glucose Intolerance, Diabetes Mellitus, MELAS Syndrome, Humans, Medicine, Child, business.industry, High-Throughput Nucleotide Sequencing, General Medicine, medicine.disease, Heteroplasmy, Mitochondria, 030220 oncology & carcinogenesis, Mutation, Female, business
Abstract: Objective: Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a very rare condition; it encompasses a diverse group of disorders including diabetes. Phenotypic variability can be attributed to heteroplasmy along with varying proportions of mutant and WT mitochondrial DNA (mtDNA). To examine the clinical relationship between mitochondrial diabetes and mutational load, we analyzed the mtDNA of children and young adolescents with MELAS syndrome using next generation sequencing (NGS). Design and methods: Of 57 subjects with suspected MELAS syndrome, 32 children and young adolescents were diagnosed as MELAS syndrome with mtDNA A-to-G transition at nucleotide 3243. Mutation load studies and NGS were performed for 25 subjects. Results: The mean mutation load was 60.4 ± 18.4% (range: 22.5‒100). Of the 25 subjects with NGS results, 15 (60%) were diagnosed with DM and 2 (8%) were diagnosed with impaired glucose tolerance (IGT). The mutational load of subjects inversely correlated with first symptom onset, age at diagnosis of MELAS syndrome, and DM (P < 0.001). However, mutational load did not correlate with the clinical severity or progression of DM/IGT. There was no significant difference in insulin resistance or sensitivity indices between the low- and high-mutation load groups. During the 3.7 years of follow-up, insulin resistance indices were not significantly different between baseline and follow-up. Conclusions: We can infer that the mutation load in the MELAS syndrome is significantly associated with the onset of symptoms and associated diseases, including mitochondrial diabetes. However, it may not influence disease progression.
Published: 2020
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48. Meta-analysis of the Effect of Exercise Intervention Program on Functional Movement

Author: Choi， Jee-Ah, Kim Young Wook, Lee Yoo-Na, and Jihoon Park
Subjects: medicine.medical_specialty, Physical medicine and rehabilitation, Exercise intervention, business.industry, Meta-analysis, Medicine, business, Functional movement
Published: 2020
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49. Neurologic deterioration in patients with acute ischemic stroke or transient ischemic attack

Author: Dae-Hyun Kim, Soo Joo Lee, Byung-Chul Lee, Yong Jin Cho, Wook-Joo Kim, Jong Moo Park, Wi Sun Ryu, Ji Sung Lee, June-Young Lee, Kang Ho Choi, Tai Hwan Park, Kyung Ho Yu, Jun Lee, Jihoon Kang, Philip B. Gorelick, Mi Sun Oh, Moo Seok Park, Dong Ick Shin, Min Ju Yeo, Joon Tae Kim, Jeong Kon Lee, Jay Chol Choi, Dong Eog Kim, Kyung Bok Lee, Jee Hyun Kwon, Sung Il Sohn, Jae Kwan Cha, Beom Joon Kim, Jeong-Ho Hong, K.S Kang, Jae Guk Kim, Hee-Joon Bae, Moon Ku Han, Sang Soon Park, Keun-Sik Hong, and Man Seok Park
Subjects: Male, medicine.medical_specialty, Time Factors, Brain Ischemia, Brain ischemia, Risk Factors, Modified Rankin Scale, Internal medicine, Humans, Medicine, Prospective Studies, Myocardial infarction, Prospective cohort study, Stroke, Aged, business.industry, Hazard ratio, Middle Aged, medicine.disease, Blood pressure, Ischemic Attack, Transient, Relative risk, Cardiology, Female, Neurology (clinical), Nervous System Diseases, business
Abstract: ObjectiveTo improve epidemiologic knowledge of neurologic deterioration (ND) in patients with acute ischemic stroke (AIS).MethodsIn this prospective observational study, we captured ND prospectively in 29,446 patients with AIS admitted to 15 hospitals in Korea within 7 days of stroke onset. ND was defined as an increase in NIH Stroke Scale (NIHSS) score ≥2 (total), or ≥1 (motor or consciousness), or any new neurologic symptoms. Change in incidence rate after stroke onset, causes, factors associated with ND, modified Rankin Scale (mRS) score at 3 months and 1 year, and a composite of stroke, myocardial infarction, and all-cause death at 1 year were assessed.ResultsND occurred in 4,299 (14.6%) patients. The highest rate, 6.95 per 1,000 person-hours incidence, was within the first 6 hours, which decreased to 2.09 within 24–48 hours, and 0.66 within 72–96 hours after stroke onset. Old age, female sex, diabetes, early arrival, large artery atherosclerosis as a stroke subtype, high NIHSS scores, glucose level, systolic blood pressure, leukocytosis at admission, recanalization therapy, TIA without a relevant lesion, and steno-occlusion of relevant arteries were associated with ND. The causes were stroke progression (71.8%) followed by recurrence (8.5%). Adjusted relative risks (95% CI) for poor outcome (mRS 3–6) at 3 months and 1 year were 1.75 (1.70–1.80) and 1.70 (1.65–1.75), respectively. The adjusted hazard ratio (95% CI) for the composite event was 1.59 (1.45–1.74).ConclusionsND should be taken into consideration as a factor that may influence the outcome in acute ischemic stroke.
Published: 2020
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50. Relationship between oil production and CO2 storage during low-salinity carbonate water injection in acid carbonate reservoirs

Author: Jihoon Wang, Yeonkyeong Lee, Wonmo Sung, and Soo Yeon Kim
Subjects: General Chemical Engineering, Water injection (oil production), 02 engineering and technology, Co2 storage, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Salinity, chemistry.chemical_compound, Permeability (earth sciences), chemistry, Mass transfer, Environmental chemistry, medicine, Carbonate, Enhanced oil recovery, Swelling, medicine.symptom, 0210 nano-technology
Abstract: This study investigates enhanced oil recovery (EOR) and CO2 storage efficiencies during low-salinity carbonate waterflooding (LSCWF) in carbonate reservoirs containing “acid” formation water. In order to identify the detailed geochemical reactions for acidic condition during LSCWF, simulational analysis was performed with “CMG-GEM”. After core-scaled model was constructed through history-matching processes based on the coreflooding experimental results, primary mechanisms during LSCWF were analyzed for various levels of injection water salinity. From the results of this study, CO2 dissolved in injected carbonate water yielded CaCO3 precipitation in acidic reservoirs, decreasing permeability significantly compared to in neutral reservoirs. In terms of wettability alteration and oil swelling by CO2 mass transfer, their effects were almost similar regardless of the salinity for both acid and neutral reservoirs. In the aspects of EOR and CO2 storage efficiencies, they strongly depend on the salinity for both acidic and neutral conditions. In the results of EOR–CO2 storage relationship, enhanced oil was smaller in acidic condition, while CO2 storage efficiency was not greatly related to acidity of the reservoir. The findings of this study can help for better understanding of smart water injection design into acid carbonate reservoir for the optimal EOR and CO2 storage efficiencies.
Published: 2020
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