1. Early Recurrence of First Unprovoked Seizures in Children
- Author
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Gregory P. Conners, Leah R Goldberg, W. Allen Hauser, Kathleen Lillis, Nathan Kuppermann, James M. Callahan, Peter S. Dayan, Catherine G Kernie, Cigdem I. Akman, Charles G. Macias, Jonathan E. Bennett, and Alpern, Elizabeth
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,Time Factors ,Adolescent ,Early Recurrence ,Clinical Sciences ,Neurodegenerative ,Logistic regression ,Seizure recurrence ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Seizures ,Recurrence ,Risk Factors ,Clinical Research ,030225 pediatrics ,Odds Ratio ,medicine ,Humans ,Child ,Preschool ,Pediatric ,Epilepsy ,business.industry ,Medical record ,Age Factors ,Neurosciences ,Infant ,Electroencephalography ,General Medicine ,Emergency department ,Odds ratio ,Emergency & Critical Care Medicine ,Confidence interval ,Brain Disorders ,Child, Preschool ,Public Health and Health Services ,Emergency Medicine ,Anticonvulsants ,Female ,business ,030217 neurology & neurosurgery ,Cohort study - Abstract
ObjectivesThe risk of early seizure recurrences after first unprovoked seizures in children is largely unknown. We aimed to determine the rate of seizure recurrence within 14 days of first unprovoked seizures in children and identify associated risk factors. Secondarily, we aimed to determine the risk of recurrence at 48 hours and 4 months.MethodsWe conducted a secondary analysis of a multicenter cohort study of children 29 days to 18 years with first unprovoked seizures. Emergency department (ED) clinicians completed standardized histories and physical examinations. The primary outcome, recurrent seizure at 14days, and the secondary outcomes, recurrence at 48 hours and 4 months, were assessed by telephone follow-up and medical record review. For each recurrence time point, we excluded those patients for whom no seizure had recurred but chronic antiepileptic drugs had been initiated.ResultsA total of 475 patients were enrolled in the parent study. Of evaluable patients for this secondary analysis, 26 of 392 (6.6%, 95% confidence interval [CI]= 4.4%-9.6%) had recurrences within 48 hours of the incident seizures, 58 of 366 (15.8%, 95% CI= 12.3%-20.0%) had recurrences within 14 days, and 107 of 340 (31.5%, 95% CI= 26.6%-36.7%) had recurrences within 4 months. On logistic regression analysis, age younger than 3 years was independently associated with a higher risk of 14-day recurrence (adjusted odds ratio [OR]= 2.1, 95% CI= 1.2-3.7; p=0.01). Having had more than one seizure within the 24 hours prior to ED presentation was independently associated with a higher risk of seizure recurrence at 48hours (adjusted OR= 4.3, 95% CI= 1.9-9.8; p 
- Published
- 2017
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