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Purpose To evaluate the peripapillary retinal nerve fiber layer (RNFL) thickness obtained with spectral-domain optical coherence tomography (OCT) in obstructive sleep apnea syndrome (OSA) patients, as a biological marker of neuronal damage. Methods Sixty-four OSA patients and one hundred twenty-nine healthy controls were prospectively selected. Only one eye per subject was randomly chosen. AOS patients were classified in three groups according to apnea/hipopnea index: mild, moderate and severe. All participants had intraocular pressure less than 21 mmHg and performed at least a reliable standard automated perimetry (SAP). Peripapillary RNFL thicknesses were measured with Cirrus OCT (Carl Zeiss Meditec, Dublin, Ca). After checking for a normal distribution of variables, differences between both groups were tested by Student t test. Results Age was 50.6 ± 9.3 years in control eyes and 47.8 ± 11.5 years in AOS patients (p = 0.09). Mean deviation of SAP was -0.50 ± 1.0 dB and -1.4± 2.3 dB, in control and AOS patients, respectively (p

Purpose To evaluate the agreement between the Moorfields regression analysis classification (MRA) of the Heidelberg retina Tomograph 3 (HRT3; Heidelberg Engineering, Heidelberg, Germany) and the functional classification of white-on-white Heidelberg Edge Perimetry (HEP, Heidelberg Engineering). Methods Fifty-seven normal subjects and 89 age-matched glaucoma subjects were selected.Only one eye per subject was randomly included in the statistical analysis. All glaucoma patients had an intraocular pressure higher than 21 mmHg and abnormal Humphrey visual fields. The glaucoma group was divided into three subsets, according to the subject’s level of visual field loss (Hodapp-Parrish-Anderson score). All participants underwent a comprehensive ophthalmic examination, at least a reliable Humphrey perimetry, at least a reliable HEP and imaging with the HRT3. The agreement between color-coded classifications of both, MRA and HEP, was calculated for each sector of the optic nerve head: nasal-superior Results Mean age was 52.9 ± 9.5 years in the control group and 55.5 ± 9.7 years in the glaucoma group (p=0.104). In the control group, the best agreement was found for NI sector (100%), while the worst agreement was observed for TI sector (93%). Patients with mild glaucoma (n=59) had the best agreement at NS sector (79.7%) while patients with moderate glaucoma (n=18) had the best agreement at NS, TS and TI sectors (88.9%), and patients with severe glaucoma (n=12) had the best agreement at NS, TS, TI and T sectors (83.3%). Conclusion In general, MRA and functional classification of HEP showed moderate to good agreement. The best agreement between both classifications was observed in healthy and patients with mild glaucoma.

Purpose To evaluate the relationship between Standard Automated Perimetry (SAP) performed with Humphrey perimeter (Carl Zeiss Meditec, EEUU) and a new white-white perimetry tested with Heidelberg Edge Perimeter (HEP, Heidelberg Engineering, Alemania). Methods Fourty-three subjects (healthy and with different levels of glaucomatous damage subjects) were prospectively and consecutively selected. Only one eye per subject was included in the study. All of them underwent at least one reliable perimetry with each device. 24-2 SITA standard was used with Humphrey perimeter and 24-2 ASTA standard algorithm was tested with HEP in all subjects. After checking the normal values of variables by Kolmogorov-Smirnov test, Pearson’s correlation coefficients were calculated between global indices of both devices: mean deviation (MD), pattern standard deviation (PSD) and visual field index (VFI). Results Mean age was of 58.41±12.4 years. Subjects had mean IOP values of 18.24±3.6 mmHg. No differences were found in mean MD values (p=0.127): -2.82±4.8 dB and -1.54±2.6 dB between Humphrey and HEP, respectively. No differences were found in mean PSD values (p=0.290) between Humphrey (3.11±3.1) and HEP (2.52±1.9). The strongest correlations were observed between PSDs (0.788; p

Purpose To compare the results obtained between Humphrey Perimeter (Carl Zeiss Meditec, EEUU) and Heidelberg Edge Perimeter (HEP, Heidelberg Engineering, Alemania) tested in a group of glaucomatous patients. Methods A total of 23 eyes of 23 glaucomatous patients were prospectively and consecutively selected. All of them had basal IOP values higher than 20 mmHg and glaucomatous optic nerve head. They were examined with Standard Automated Perimetry (SAP) using 24-2 SITA standard and HEP perimetry using 24-2 ASTA standard algorithm. They performed at least one reliable perimetry with each device. Spearman‘s correlation coefficients were calculated between global indices of both devices: mean deviation (MD), pattern standard deviation (PSD) and visual field index (VFI). Results Mean age was of 65.07±8.67 years. Subjects had mean IOP values of 24.43±1.90 mmHg. The mean MD values were -6.73±6.23 and -2.89±3.26 measured with Humphrey and HEP perimeters respectively. And the mean PSD values were 6.07±3.62 and 3.80±2.45 measured with Humphrey and HEP perimeters respectively. The strongest correlations were observed between MDs (0.683; p=0.001) and between PSDs (0.619; p=0.003). Conclusion Humphrey and HEP perimeter correlated well in some global values. Further studies are required to evaluate the clinical usefulness of HEP perimeter in glaucoma patients.

Purpose To compare the main indices of flicker FDF perimetry (FDF, Heidelberg Engineering, Germany) with standard automated perimetry (SAP). Methods Twenty healthy subjects and twenty-three glaucoma patients were prospectively and consecutively selected. Glaucomatous patients had an intraocular pressure higher than 21 mmHg and glaucomatous optic disc appearance. All of them underwent at least one reliable perimetry with each device. SAPs were performed with a FDF perimeter (24-2 ASTA-Standard test) and Humphrey perimeter (Carl Zeiss (24-2 SITA standard algorithm). The Kolmogorov Smirnov test was applied to check that the data were normally distributed. Only one eye per subject was included in the study. Pearson correlations were calculated between both devices : mean deviation (MD), pattern standard deviation (PSD), and visual field index (VFI). Results Mean age was 58.41±12,4 years. MD of SAP was -2.82 ± 4.8 dB, and MD of FDF was -4.47 ± 4.8 dB (p=0.123); PSD of SAP was 3.11 ± 3.1, and PSD of FDF was 3.14 ± 1.4 (p = 0.953). The correlations between MDs were 0.521 (p

Purpose To compare the main indices of flicker FDF perimetry (FDF, Heidelberg Engineering, Germany) with standard automated perimetry (SAP) in glaucoma patients. Methods Twenty-three open-angle glaucoma patients were prospectively and consecutively selected. Glaucomatous patients had an intraocular pressure higher than 21 mmHg and glaucomatous optic disc appearance. All of them underwent at least one reliable perimetry with each device. SAPs were performed with a FDF perimeter (24-2 ASTA-Standard test) and Humphrey perimeter (Carl Zeiss (24-2 SITA standard algorithm). The Kolmogorov Smirnov test was applied to check that the data were normally distributed. Only one eye per subject was included in the study. Spearman correlations were calculated between both devices : mean deviation (MD), pattern standard deviation (PSD), and visual field index (VFI). Results : Mean age was 65.07±8.67 years. MD of SAP was -6.73 ± 6.23 dB, and MD of FDF was -7.70 ± 5.84 dB (p=0,123); PSD of SAP was 6.07 ± 3.62, and PSD of FDF was 3.91 ± 1.89 (p = 0.953). The correlations between MDs were 0.736 (p 0.05) Conclusion Moderate correlations were found between main visual field indices both devices. Altough no differences were found, FDF tends to present MD values lower than Humphrey.