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The aim of the study was to evaluate the effect of nootropics on vegetal disbalance and psychological status in child athletes.

A significant increase in human papillomavirus-associated cervical oncological diseases, a high rate of recurrence of the process (4862.4%) after surgical treatment, changes in the local immune microenvironment in cervical biopsy specimens with (HSIL) created the prerequisites for studying the clinical efficacy of local immunocorrection in complex HSIL therapy. Aim. To study the clinical efficacy of local immunocorrection of azoximer with bromide in the complex therapy of cervical intraepithelial neoplasias. Materials and methods. Examination and treatment of 40 patients with HSIL was carried out. The study of the effectiveness of azoximer bromide in complex therapy in patients with cervical intraepithelial neoplasias of a high degree of oncogenic risk was carried out on the basis of an immunohistochemical study of cervicobioptates to markers CD3, CD56, CD20, CD138, M-CSF. Results and discussion. It was revealed that cervical intraepithelial neoplasias of a high degree of oncogenic risk are accompanied by changes in the local immune microenvironment in the epithelium and stroma of neoplastic altered tissues, which may contribute to the development of neoplasia progression. The inclusion of a local immunomodulator azoximer bromide in the complex therapy helped to reduce the recurrence of the process by 2 times, the elimination of the human papillomavirus by 3.5 times relative to the comparison group. Conclusion. 1. In cervico-biopsy specimens of patients with HSIL, there is an increase in the proportion of cells with expression of receptors CD20, CD3, CD138 (in stromal cells) and a decrease in epithelial infiltration with M-CSF, which indicates significant changes in immune homeostasis in cells of the affected epithelium. Based on the results obtained, at the stage of preparation for surgical treatment of patients with HSIL, it is advisable to include local immunocorrection to improve the outcome of therapy. 2. The inclusion of a local immunomodulator azoximer bromide in the complex therapy helped to reduce the recurrence of the process by 2 times, the elimination of the human papillomavirus by 3.5 times, which dictates the need for complex immunomodulation in the treatment of HSIL at the stage of preparation for surgery.

In chronic infections caused by retroviruses, "antigen antibody" immune complexes (AAC) appear in body fluids. In the course of the studies to clarify the structure of the AAC we proved that immune complexes in cattle leukemia could contain the virus's viral DNA. The role of circulating immune complexes in the pathogenesis of the bovine leukemia virus (BLV) infection is not sufficiently studied. AAC containing the viral DNA may be formed during the death of infected B-lymphocytes by linking non-invasive viral DNA to surface IgMs with high DNA affinity. Determining the appearance of AAC with the viral DNA in biological fluids depending on the stages of the infectious process is an important criterion in antileukemia measures. The article describes the results of research to determine circulating immune complexes containing the provirus DNA in the milk of cows infected with BLV as compared with hematological changes at different stages of the infection process. It is reported that the viral DNA in the AAC of the milk of cows infected with BLV is detected much earlier than hematological changes that allow to consider them leukemia patients. Of the 12 cows studied, by the end of the experiment, six cows had AAC containing the viral DNA in their milk samples. And only one cow with the detection of the viral DNA in the AAC of milk showed parallel hematological changes typical for leukemia. The use of milk samples for molecular genetic analysis to identify BLV in AAC is quite a promising area for assessing the epizootic situation on farms and is very informative in determining the animal status.