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The aim of this study is to estimate the levels of serum uric acid in patients with acute myocardial infarction and also to study the correlation with Killip’s Classification of Cardiac failure. This is a cross sectional study, we selected the patients from ICCU and emergency department. 30 patients with AMI and age matched controls taken for study. Uric acid levels measured in Autoanalyzer Beckman Coulter AU 480. The mean serum uric acid among the study group and the control group on the day of admission (Day 0) was 7.6 ± 1.6 and 5.4 ± 1.2 respectively. There was a gradual increase in the SUA levels on Day 0, 3 and 7 and was proportionate with the increasing Killip’s class. It is concluded that the serum uric acid (SUA) levels are increased significantly among patients diagnosed with acute myocardial infarction (AMI)when compared with the controls. It is also evident that there is a significant correlation between SUA levels and the severity of the AMI based on the Killip’s classification. Higher the Killip’s class, higher the uric acid levels. Therefore, SUA shall be used as a marker in diagnosing and as a cofactor useful along with other clinical examinations and investigations to interpret the severity of AMI as well. However, additional work must be done to understand the full clinical potential of Uric acid and correlation with other cardiac failure parameters.

Improvement in Surgical and Anaesthetic techniques allows even complex surgeries to be performed as day care cases. The objective of the study is to compare the recovery parameters of patients undergoing anaesthesia for ambulatory surgeries under General or Spinal Anaesthesia.After approval by IEC, this study was performed in 60 patients undergoing elective ureteroscopic procedures. Patients were Randomized to receive either General anaesthesia (Group GA: n=30) or Spinal Anaesthesia (Group GA: n=30). GA was induced using standard protocols with airway maintained spontaneously using LMA. In group SA patients received 1.5 ml 0.75% Isobaric Ropivacaine for providing anaesthesia. Vitals were recorded in both the groups throughout the procedure. In addition to intra operative haemodynamics, the onset of duration and percentage of patients achieving complete sensory & motor block was also recorded in SA group. Patients were kept in phase I recovery till score of Aldrete 9 was reached. In phase II recovery (PACU) the percentage of patients sitting at 180 min, standing at 300 min and walking at 360 min were recorded. The psychomotor skills of patients were assessed using digit symbol substitution test (DSST) before discharging from phase II recovery. The main criteria for discharging patients from phase II recovery was Post Anaesthesia Discharge scoring (PADSS). Patients were discharged from phase II recovery on reaching PADSS Seventy three patients were enrolled and 60 patients completed the study. The onset of sensory and motor block in Group SA was 6.61±0.83 min and the onset of motor block was 9.48±0.91 min. Percentage of patients achieving complete sensory & motor block was 71%. The duration of sensory block was 208± 17.95 min and the duration of motor block was 182.07±15.98. Patients in group GA took 221.07± 4.97 and Group SA took 110.72± 7.04 min to reach Aldrete score of 10 (p value The technique of Anaesthesia doesn’t interfere with readiness of patients to discharge home in terms of maintain stable vitals, pain or side effects. Isobaric Ropivacaine was found to be a poor choice for providing spinal anaesthesia due to slow onset of sensory block, inability to achieve complete motor block thus providing difficulty to operating surgeon.

Introduction: Dengue is an arboviral disease endemic in India. Severe dengue has a high morbidity. The progression to severe dengue may be diagnosed by clinical and lab parameters, are of the useful lab tests is platelet count, as thrombocytopenia is a consistent feature in dengue. There is confusion about the role thrombocytopenia in dengue. Our study aims to study the platelet count patterns and its relevance to severity of dengue. Materials and Methods: We conducted a study on 132 dengue positive cases with relevant hematology data in November 2016. Results: We had predominance of young people and males in the study group. Thrombocytopenia was uniform across the ages and sexes. Severe thrombocytopenia constituted 56%, had significant association with atypical lymphocytosis, rise in hematocrit and antibody patterns. Conclusion: Platelet counts are marker of dengue, can serve as predicators of severity, platelet count monitoring helps guide transfusion therapy. Keywords: Dengue, Platelet count, Total count, Differential count, Hematocrit, Serology.

Background: Dengue, endemic in India presents in mild to severe forms with or without bleeding. There is no specific treatment available till date hence severe dengue has to be recognized in early stages. Platelet counts are unreliable as they do not correlate with bleeding. Platelet indices have been studied for their utility as predictors of severity of the disease and aid in guide to transfusion therapy. Mean platelet volume is inexpensive and available with routine complete blood counts in hematology analyser. Its role as marker in diagnosis, prognosis and treatment of dengue has been investigated with platelet indices reports. Aims: To study MPV patterns, association with platelet counts and relevant laboratory parameters in dengue. Methods: The study was conducted over one month in the year 2016 in department of Hematology, Kempegowda Institute of Medical Sciences Hospital, Bengaluru. 100 serologically proven dengue cases were analysed with data collected from the records in the departments of Hematology and Microbiology against patient’s unique hospital identification number. Results: There was a predominance of young aged and male patients. The range for MPV was 8.7 – 13.2 (average 10.95) with 35% normal and 65% high MPV cases. There was 48% cases with moderately severe / severe thrombocytopenia. 32% with increased hematocrit, 35% with leucopenia, 54% with significant atypical lymphocytosis and 42% with antibody pattern. There was an increased number of high MPV seen in severe thrombocytopenia, increased hematocrit significant atypical lymphocytosis and antibody pattern whereas normal pattern was noted in leucopenia. Conclusion: High MPV is a useful predictor of severe dengue platelet recovery and may guide in transfusion therapy. Keywords: MPV, Dengue, Platelet.

Objective: To estimate the levels of zinc and copper in the cases of preeclampsia. To know the importance of the same in pregnancy. Materials and Methods: 30 preeclamptic cases and 30 pregnant women with normal blood pressure were estimated for serum zinc and copper levels. Results: The levels of the trace elements, zinc and copper were found to be decreased in preeclamptic pregnancy when compared to the normal pregnancy without complications. Conclusion: The decreased levels of zinc and copper in preeclampsia might be responsible for the complications in pregnancy as well as post-pregnancy complications. Keywords: Zinc, Copper, Preeclampsia, Pregnancy.

Introduction: Diabetes mellitus is the most common endocrine disorder caused by absolute or relative deficiency of insulin. Chronic hyperglycemia and enhanced oxidative stress have been implicated in the pathogenesis of diabetic vascular complications. These patients are more prone to adverse cardiovascular events which occur due to the accelerated rate of atherosclerosis in diabetic patients. Myeloperoxidase apart from playing a major role in innate immunity has been implicated in the various stages of atherosclerosis namely initiation, progression and plaque rupture. The objective of the study was to estimate the plasma myeloperoxidase activity in type-2 diabetics and to establish a correlation between plasma myeloperoxidase activity and lipid profile and glycated haemoglobin (HbA1c) in the study population. Methods: Plasma myeloperoxidase activity was estimated by spectrophotometric method using O-dianisidine dihydrochloride as substrate. Lipid profiles, HbA1c and blood sugar was analysed in an auto- analyser. Results: There was a statistically significant increase in plasma myeloperoxidase activity in diabetic patients when compared with non-diabetic individuals (p

Objective: More than 50% of the world’s population is considered overweight and being overweight is associated with several comorbidities such as Type 2 diabetes mellitus, hypertension, cardiovascular diseases, dyslipidemia, respiratory diseases, osteoarthritis, and depression. Therefore, in this study, we have estimated the high sensitive C-reactive protein (hs-CRP) levels in obese, overweight, and normal body mass index (BMI) individuals and whether there was any relationship between hs-CRP and other risk factors of the cardiovascular system such as serum total cholesterol (TC) and other lipids.Methods: A total of 150 participants, divided into three groups. Group I - 50 participants with normal BMI (18–22.99 kg/m2), Group II - 50 participants who were overweight (BMI = 23–24.99 kg/m2), and Group III - 50 who were obese (BMI ≥25 kg). We measured fasting plasma glucose, postprandial plasma glucose, serum TC, triacylglycerol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and hs-CRP.Results: Obese individuals had increased hs-CRP compared with control (Group I) and overweight (Group II) groups. hs-CRP positively correlated with BMI and lipid profile.Conclusion: Elevated hs-CRP was associated with cardiovascular risk factors in overweight and obese individuals. This high-risk group should be targeted for therapeutic lifestyle modifications to prevent further complications.

Previous studies have localized the region of the latency-associated transcript (LAT) of HSV-1 responsible for epinephrine-induced reactivation in the rabbit eye model to the first 1.5 kb of the primary transcript. This region extends from the 5prime prime or minute exon of the primary LAT transcript through the 5prime prime or minute half of the LAT 2.0-kb intron. To determine whether the 5prime prime or minute end of the LAT intron contributes to the induced reactivation phenotype, three recombinant viruses containing deletions within this portion of the LAT intron were constructed. The three recombinants, containing deletions spanning a combined region of 969 bp at the 5prime prime or minute end of the LAT intron, reactivated with the wild-type frequency of 17syn+. These results indicate that the elements governing induced reactivation reside within the first 699 bp of the primary LAT transcript encoding the 5prime prime or minute LAT exon.

The cytological features of myoepithelioma of the parotid gland are documented in only a few case reports. We describe the fine-needle aspiration cytological findings in a case of epithelioid myoepithelioma of the parotid gland in a 43-year-old male. The differential diagnosis with other salivary gland neoplasms is discussed.

Leiomyoma-a benign smooth muscle tumor which is most commonly reported in uterus and gastrointestinal tract is rare in the upper aero-digestive tract due to the paucity of smooth muscle in the area. To the best of our knowledge, only 40 cases of leiomyoma occurring in larynx have been reported since 1966 in English literature. We report a case in a 18-year-old lady who presented with recurrent laryngeal leiomyoma which was confirmed by immunohistochemistry. The post-operative course was uneventful.