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1. Simple parameters from complete blood count predict in-hospital mortality in covid-19

Author

Bellan, M., Azzolina, D., Hayden, E., Gaidano, G., Pirisi, M., Acquaviva, A., Aimaretti, G., Valletti, P. A., Angilletta, R., Arioli, R., Avanzi, G. C., Avino, G., Balbo, P. E., Baldon, G., Baorda, F., Barbero, E., Baricich, A., Barini, M., Barone-Adesi, F., Battistini, S., Beltrame, M., Bertoli, M., Bertolin, S., Bertolotti, M., Betti, M., Bobbio, F., Boffano, P., Boglione, L., Borre, S., Brucoli, M., Calzaducca, E., Cammarata, E., Cantaluppi, V., Cantello, R., Capponi, A., Carriero, A., Casciaro, G. F., Castello, L. M., Ceruti, F., Chichino, G., Chirico, E., Cisari, C., Cittone, M. G., Colombo, C., Comi, C., Croce, E., Daffara, T., Danna, P., Corte, F. D., de Vecchi, S., Dianzani, U., Benedetto, D. D., Esposto, E., Faggiano, F., Falaschi, Z., Ferrante, D., Ferrero, A., Gagliardi, I., Galbiati, A., Gallo, S., Garavelli, P. L., Gardino, C. A., Garzaro, M., Gastaldello, M. L., Gavelli, F., Gennari, A., Giacomini, G. M., Giacone, I., Via, V. G., Giolitti, F., Gironi, L. C., Gramaglia, C., Grisafi, L., Inserra, I., Invernizzi, M., Krengli, M., Labella, E., Landi, I. C., Landi, R., Leone, I., Lio, V., Lorenzini, L., Maconi, A., Malerba, M., Manfredi, G. F., Martelli, M., Marzari, L., Marzullo, P., Mennuni, M., Montabone, C., Morosini, U., Mussa, M., Nerici, I., Nuzzo, A., Olivieri, C., Padelli, S. A., Panella, M., Parisini, A., Pasche, A., Patrucco, F., Patti, G., Pau, A., Pedrinelli, A. R., Percivale, I., Ragazzoni, L., Re, R., Rigamonti, C., Rizzi, E., Rognoni, A., Roveta, A., Salamina, L., Santagostino, M., Saraceno, M., Savoia, P., Sciarra, M., Schimmenti, A., Scotti, L., Spinoni, E., Smirne, C., Tarantino, V., Tillio, P. A., Tonello, S., Vaschetto, R., Vassia, V., Zagaria, D., Zavattaro, E., Zeppegno, P., Zottarelli, F., Sainaghi, P. P., Aiosa, G., Airoldi, A., Barco, A., Bargiacchi, O., Bazzano, S., Berni, P., Bianchi, B., Bianco, S., Biffi, S., Binda, V., Bolgeo, T., Bolla, C., Bonato, V., Bonizzoni, G., Bragantini, A., Brustia, D., Bullara, V., Burlone, M., Brustia, F., Caccia, S., Calareso, A., Cammarota, G., Cancelliere, L., Carbone, R., Cassinari, A., Ceriani, E., Cena, T., Clivati, E., Collimedaglia, L., Colombatto, A., Cornella, C., Costanzo, M., Croce, A., de Benedittis, C., Delorenzi, S., Dionisio, R., Donato, P., Esposito, M., Fangazio, S., Feggi, A., Ferrillo, S., Foci, V., Fra, G. P., Gaggino, C., Gambaro, E., Gattoni, E., Gattoni, L., Giacchero, F., Gianfreda, R., Giubertoni, A., Grecu, L., Grossi, F., Guglielmetti, G., Guido, S., Iannantuoni, G., Ingrao, S., Jona, A., Lazzarich, E., Lissandrin, R., Maduli, E., Magne, F., Mantia, E., Marangon, D., Massara, M., Matino, E., Mauri, M. G., Menegatti, M., Moglia, R., Molinari, R., Morelli, S., Morlino, P., Naldi, P., Nebbiolo, C., Omodeo, P., Palmieri, D., Panero, A., Parodi, M., Pedrazzoli, R., Pelazza, C., Penpa, S., Perucca, R., Pirovano, A., Pittau, S., Pochetti, P., Poletti, F., Polla, B., Prandi, P., Prodam, F., Prosperini, P., Puma, A., Quaglia, M., Raie, A., Rapetti, R., Ravera, S., Re, A., Reale, M., Rossati, A., Rossi, M., Rossi, P., Rostagno, R., Salomoni, G., Sama, M. T., Sarchi, E., Sarcoli, M., Sarda, C., Sguazzotti, I., Soddu, D., Sola, D., Stobbione, P., Todoerti, M., Vallese, G. C., Varrasi, C., Veia, A., Vignazia, G. L., Zanotti, I., Zecca, E., Zichittella, D., Zisa, G., and Zoppis, E.

Subjects
Adult, Male, medicine.medical_specialty, Medicine (General), Multivariate analysis, Article Subject, Clinical Decision Rules, COVID-19, Prognosis, Blood Cell Count, Hospital Mortality, Severity of Illness Index, Clinical Biochemistry, Asymptomatic, Severity of Illness Index, NO, R5-920, Internal medicine, Clinical Decision Rules, Severity of illness, Genetics, 80 and over, Medicine, Humans, Hospital Mortality, Molecular Biology, Aged, Retrospective Studies, Aged, 80 and over, medicine.diagnostic_test, business.industry, Biochemistry (medical), Complete blood count, COVID-19, Retrospective cohort study, Red blood cell distribution width, General Medicine, Odds ratio, Middle Aged, Prognosis, Female, Italy, Multivariate Analysis, Blood Cell Count, Cohort, medicine.symptom, business, Research Article
Abstract

Introduction. The clinical course of Coronavirus Disease 2019 (COVID-19) is highly heterogenous, ranging from asymptomatic to fatal forms. The identification of clinical and laboratory predictors of poor prognosis may assist clinicians in monitoring strategies and therapeutic decisions. Materials and Methods. In this study, we retrospectively assessed the prognostic value of a simple tool, the complete blood count, on a cohort of 664 patients ( F 260; 39%, median age 70 (56-81) years) hospitalized for COVID-19 in Northern Italy. We collected demographic data along with complete blood cell count; moreover, the outcome of the hospital in-stay was recorded. Results. At data cut-off, 221/664 patients (33.3%) had died and 453/664 (66.7%) had been discharged. Red cell distribution width (RDW) ( χ 2 10.4; p < 0.001 ), neutrophil-to-lymphocyte (NL) ratio ( χ 2 7.6; p = 0.006 ), and platelet count ( χ 2 5.39; p = 0.02 ), along with age ( χ 2 87.6; p < 0.001 ) and gender ( χ 2 17.3; p < 0.001 ), accurately predicted in-hospital mortality. Hemoglobin levels were not associated with mortality. We also identified the best cut-off for mortality prediction: a NL ratio > 4.68 was characterized by an odds ratio for in-hospital mortality OR = 3.40 (2.40-4.82), while the OR for a RDW > 13.7 % was 4.09 (2.87-5.83); a platelet count > 166,000 /μL was, conversely, protective (OR: 0.45 (0.32-0.63)). Conclusion. Our findings arise the opportunity of stratifying COVID-19 severity according to simple lab parameters, which may drive clinical decisions about monitoring and treatment.

Published
2021

2. The association between insight and depressive symptoms in schizophrenia: Undirected and Bayesian network analyses

Author

Amore, M., Murri, M. B., Calcagno, P., Rocca, P., Rossi, A., Aguglia, E., Bellomo, A., Blasi, G., Carpiniello, B., Cuomo, A., Dell'Osso, L., Di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Corso, A., Arzani, C., Galderisi, S., Maj, M., Petrilli, G., Respino, M., Papalino, M., Falsetti, A., Calia, V. M., Barlati, S., Deste, G., Turrina, C., Pinna, F., Lai, A., Di Santa Sofia, S. L., Signorelli, M. S., Petralia, A., Pettorruso, M., Barone, G., Salone, A., Piegari, G., Aiello, C., Brando, F., Giuliani, L., Altamura, M., Carnevale, R., Padalino, F., Giusti, L., Salza, A., Ussorio, D., Pizziconi, G., Santarelli, V., Pacitti, F., De Bartolomeis, A., Gambaro, E., Gattoni, E., Gramaglia, C., De Panfilis, C., Ossola, P., Tonna, M., Carmassi, C., Carpita, B., Cremone, I., Comparelli, A., Corigliano, V., Brugnoli, R., Corrivetti, G., Cascino, G., Del Buono, G., Fagiolini, A., Bolognesi, S., Goracci, A., Di Lorenzo, G., Niolu, C., Ribolsi, M., Bellino, S., Bozzatello, P., Brasso, C., Amore, M., Murri, M. B., Calcagno, P., Rocca, P., Rossi, A., Aguglia, E., Bellomo, A., Blasi, G., Carpiniello, B., Cuomo, A., Dell'Osso, L., di Giannantonio, M., Giordano, G. M., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Corso, A., Arzani, C., Galderisi, S., and Maj, M.

Subjects
Adult, Male, media_common.quotation_subject, Social Stigma, Hostility, NO, Suicidal Ideation, Extrapyramidal symptoms, Demoralization, depression, insight, sadness, schizophrenia, self-esteem, Sadness, Self-esteem, medicine, Humans, Suicidal ideation, media_common, Depression, Insight, Schizophrenia, Bayes Theorem, Cross-Sectional Studies, Diagnostic and Statistical Manual of Mental Disorders, Female, Middle Aged, Self Concept, Social Class, Guilt, Schizophrenic Psychology, Positive and Negative Syndrome Scale, Sadne, medicine.disease, Psychiatry and Mental health, Settore MED/25, medicine.symptom, Psychology, Neurocognitive, Research Article, Clinical psychology, Diagnosis of schizophrenia
Abstract

Background. Greater levels of insight may be linked with depressive symptoms among patients with schizophrenia, however, it would be useful to characterize this association at symptom-level, in order to inform research on interventions. Methods. Data on depressive symptoms (Calgary Depression Scale for Schizophrenia) and insight (G12 item from the Positive and Negative Syndrome Scale) were obtained from 921 community-dwelling, clinically-stable individuals with a DSM-IV diagnosis of schizophrenia, recruited in a nationwide multicenter study. Network analysis was used to explore the most relevant connections between insight and depressive symptoms, including potential confounders in the model (neurocognitive and social-cognitive functioning, positive, negative and disorganization symptoms, extrapyramidal symptoms, hostility, internalized stigma, and perceived discrimination). Bayesian network analysis was used to estimate a directed acyclic graph (DAG) while investigating the most likely direction of the putative causal association between insight and depression. Results. After adjusting for confounders, better levels of insight were associated with greater self-depreciation, pathological guilt, morning depression and suicidal ideation. No difference in global network structure was detected for socioeconomic status, service engagement or illness severity. The DAG confirmed the presence of an association between greater insight and self-depreciation, suggesting the more probable causal direction was from insight to depressive symptoms. Conclusions. In schizophrenia, better levels of insight may cause self-depreciation and, possibly, other depressive symptoms. Person-centered and narrative psychotherapeutic approaches may be particularly fit to improve patient insight without dampening self-esteem., Highlights Better insight seems associated with depressive symptoms in schizophrenia.Network analyses were used to explore this association in a large sample.Insight was associated with self-depreciation, guilt, and suicidal ideation.Although cross-sectional, data suggest causal direction from insight to depression.

Published
2020

3. Familial aggregation of MATRICS Consensus Cognitive Battery scores in a large sample o outpatients with schizophrenia and their unaffected relatives

Author

Mucci A., Galderisi S., Green M. F., Nuechterlein K., Rucci P., Gibertoni D., Rossi A., Rocca P., Bertolino A., Bucci P., Hellemann G., Spisto M., Palumbo D., Aguglia E., Amodeo G., Amore M., Bellomo A., Brugnoli R., Carpiniello B., Dell'osso L., Di Fabio F., Di Giannantonio M., Di Lorenzo G., Marchesi C., Monteleone P., Montemagni C., Oldani L., Romano R., Roncone R., Stratta P., Tenconi E., Vita A., Zeppegno P., Maj M., Piegari G., Vignapiano A., Caputo F., Plescia G., Montefusco V., Mancini M., Attrotto M. T., Paladini V., Atti A. R., Barlati S., Galluzzo A., Mussoni C., Pinna F., Sanna L., Primavera D., Signorelli M. S., Minutolo G., Cannavo D., Acciavatti T., Santacroce R., Corbo M., Altamura M., La Montagna M., Carnevale R., Pizziconi G., Rossi R., Santarelli V., Giusti L., Malavolta M., Salza A., Murri M. B., Calcagno P., Bugliani M., Serati M., Orsenigo G., Gramaglia C., Gattoni E., Cattaneo C., Campagnola N., Ferronato L., Piovan C., Tonna M., Bettini E., Ossola P., Gesi C., Landi P., Rutigliano G., Biondi M., Girardi P., Buzzanca A., Zocconali M., Comparelli A., Mancinelli I., Niolu C., Ribolsi M., Siracusano A., Corrivetti G., Bartoli L., Diasco F., Bolognesi S., Goracci A., Fagiolini A., Bellino S., Cardillo S., Bracale N., Mucci, A., Galderisi, S., Green, M. F., Nuechterlein, K., Rucci, P., Gibertoni, D., Rossi, A., Rocca, P., Bertolino, A., Bucci, P., Hellemann, G., Spisto, M., Palumbo, D., Aguglia, E., Amodeo, G., Amore, M., Bellomo, A., Brugnoli, R., Carpiniello, B., Dell'Osso, L., Di Fabio, F., Di Giannantonio, M., Di Lorenzo, G., Marchesi, C., Monteleone, P., Montemagni, C., Oldani, L., Romano, R., Roncone, R., Stratta, P., Tenconi, E., Vita, A., Zeppegno, P., Maj, M., Piegari, G., Vignapiano, A., Caputo, F., Plescia, G., Montefusco, V., Mancini, M., Attrotto, M. T., Paladini, V., Atti, A. R., Barlati, S., Galluzzo, A., Mussoni, C., Pinna, F., Sanna, L., Primavera, D., Signorelli, M. S., Minutolo, G., Cannavo, D., Acciavatti, T., Santacroce, R., Corbo, M., Altamura, M., La Montagna, M., Carnevale, R., Pizziconi, G., Rossi, R., Santarelli, V., Giusti, L., Malavolta, M., Salza, A., Murri, M. B., Calcagno, P., Bugliani, M., Serati, M., Orsenigo, G., Gramaglia, C., Gattoni, E., Cattaneo, C., Campagnola, N., Ferronato, L., Piovan, C., Tonna, M., Bettini, E., Ossola, P., Gesi, C., Landi, P., Rutigliano, G., Biondi, M., Girardi, P., Buzzanca, A., Zocconali, M., Comparelli, A., Mancinelli, I., Niolu, C., Ribolsi, M., Siracusano, A., Corrivetti, G., Bartoli, L., Diasco, F., Bolognesi, S., Goracci, A., Fagiolini, A., Bellino, S., Cardillo, S., Bracale, N., and di Giannantonio, M.

Subjects
Attention, MCCB Italian standardization, reasoning and problem solving, social cognition, verbal learning, working memory, Proband, Adult, Male, Consensus, Psychometrics, Context (language use), social cognition, Verbal learning, working memory, 03 medical and health sciences, Attention, MCCB Italian standardization, reasoning and problem solving, verbal learning, Aged, Cognition, Cognitive Dysfunction, Family, Female, Humans, Middle Aged, Outpatients, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, 0302 clinical medicine, Social cognition, medicine, Applied Psychology, Psychiatry and Mental Health, Family aggregation, medicine.disease, 030227 psychiatry, Settore MED/25, Psychology, MATRICS, Neurocognitive, 030217 neurology & neurosurgery, Clinical psychology
Abstract

BackgroundThe increased use of the MATRICS Consensus Cognitive Battery (MCCB) to investigate cognitive dysfunctions in schizophrenia fostered interest in its sensitivity in the context of family studies. As various measures of the same cognitive domains may have different power to distinguish between unaffected relatives of patients and controls, the relative sensitivity of MCCB tests for relative–control differences has to be established. We compared MCCB scores of 852 outpatients with schizophrenia (SCZ) with those of 342 unaffected relatives (REL) and a normative Italian sample of 774 healthy subjects (HCS). We examined familial aggregation of cognitive impairment by investigating within-family prediction of MCCB scores based on probands’ scores.MethodsMultivariate analysis of variance was used to analyze group differences in adjusted MCCB scores. Weighted least-squares analysis was used to investigate whether probands’ MCCB scores predicted REL neurocognitive performance.ResultsSCZ were significantly impaired on all MCCB domains. REL had intermediate scores between SCZ and HCS, showing a similar pattern of impairment, except for social cognition. Proband's scores significantly predicted REL MCCB scores on all domains except for visual learning.ConclusionsIn a large sample of stable patients with schizophrenia, living in the community, and in their unaffected relatives, MCCB demonstrated sensitivity to cognitive deficits in both groups. Our findings of significant within-family prediction of MCCB scores might reflect disease-related genetic or environmental factors.

Published
2018

4. The influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophrenia

Author

Galderisi, S, Rossi, A, Rocca, P, Bertolino, A, Mucci, A, Bucci, P, Rucci, P, Gibertoni, D, Aguglia, E, Amore, M, Bellomo, A, Biondi, M, Brugnoli, R, Dell'Osso, L, De Ronchi, D, Di Emidio, G, Di Giannantonio, M, Fagiolini, A, Marchesi, C, Monteleone, P, Oldani, L, Pinna, G, S, Pinna, F, Roncone, R, Sacchetti, E, Santonastaso, P, Siracusano, A, Vita, A, Zeppegno, P, Maj, M, Chieffi, M, De Simone, S, De Riso, F, Giugliano, R, Piegari, G, Vignapiano, A, Caforio, G, Mancini, M, Colagiorgio, L, Porcelli, S, Salfi, R, Bianchini, O, Galluzzo, A, Barlati, S, Carpiniello, B, Fatteri, F, Di Santa Sofia, S, Cannavò, D, Minutolo, G, Signorelli, M, Martinotti, G, Di Iorio, G, Acciavatti, T, Pallanti, S, Faravelli, C, Altamura, M, Stella, E, Marasco, D, Calcagno, P, Respino, M, Marozzi, V, Riccardi, I, Collazzoni, A, Stratta, P, Giusti, L, Ussorio, D, Delauretis, I, Serati, M, Caldiroli, A, Palazzo, C, Iasevoli, Fz, Gramaglia, C, Gili, S, Gattoni, E, Tenconi, E, Giannunzio, V, Monaco, F, De Panfilis, C, Camerlengo, A, Ossola, P, Landi, P, Rutigliano, G, Pergentini, I, Mauri, M, Di Fabio, F, Torti, C, Buzzanca, A, Comparelli, A, De Carolis, A, Corigliano, V, DI LORENZO, G, Niolu, C, Troisi, A, Corrivetti, Aa, G, Pinto, Diasco, Aa, F, Goracci, A, Bolognesi, S, Borghini, E, Montemagni, C, Frieri, T, Birindelli, N, Galderisi, S., Rossi, A., Rocca, P., Bertolino, A., Mucci, A., Bucci, P., Rucci, P., Gibertoni, D., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Brugnoli, R., Dell'Osso, L., De Ronchi, D., Di Emidio, G., Di Giannantonio, M., Fagiolini, A., Marchesi, C., Monteleone, P., Oldani, L., Pinna, F., Roncone, R., Sacchetti, E., Santonastaso, P., Siracusano, A., Vita, A., Zeppegno, P., Maj, M., Chieffi, M., De Simone, S., De Riso, F., Giugliano, R., Piegari, G., Vignapiano, A., Caforio, G., Mancini, M., Colagiorgio, L., Porcelli, S., Salfi, R., Bianchini, O., Galluzzo, A., Barlati, S., Carpiniello, B., Fatteri, F., Di Santa Sofia, S. L., Cannavo, D., Minutolo, G., Signorelli, M., Martinotti, G., Di Iorio, G., Acciavatti, T., Pallanti, S., Faravelli, C., Altamura, M., Stella, E., Marasco, D., Calcagno, P., Respino, M., Marozzi, V., Riccardi, I., Collazzoni, A., Stratta, P., Giusti, L., Ussorio, D., Delauretis, I., Serati, M., Caldiroli, A., Palazzo, C., Iasevoli, F., Gramaglia, C., Gili, S., Gattoni, E., Tenconi, E., Giannunzio, V., Monaco, F., De Panfilis, C., Camerlengo, A., Ossola, P., Landi, P., Rutigliano, G., Pergentini, I., Mauri, M., Di Fabio, F., Torti, C., Buzzanca, A., Comparelli, A., De Carolis, A., Corigliano, V., Di Lorenzo, G., Niolu, C., Troisi, A., Corrivetti, G., Pinto, G., Diasco, F., Goracci, A., Bolognesi, S., Borghini, E., Montemagni, C., Frieri, T., Birindelli, N., Galderisi, Silvana, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Mucci, Armida, Bucci, Paola, Rucci, Paola, Gibertoni, Dino, Aguglia, Eugenio, Amore, Mario, Bellomo, Antonello, Biondi, Massimo, Brugnoli, Roberto, Dell'Osso, Liliana, De Ronchi, Diana, Di Emidio, Gabriella, Di Giannantonio, Massimo, Fagiolini, Andrea, Marchesi, Carlo, Monteleone, Palmiero, Oldani, Lucio, Pinna, Federica, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Maj, Mario, Chieffi, Marcello, De Simone, Stefania, De Riso, Francesco, Giugliano, Rosa, Piegari, Giuseppe, Vignapiano, Annarita, Caforio, Grazia, Mancini, Marina, Colagiorgio, Lucia, Porcelli, Stefano, Salfi, Raffaele, Bianchini, Oriana, Galluzzo, Alessandro, Barlati, Stefano, Carpiniello, Bernardo, Fatteri, Francesca, Di Santa Sofia, Silvia Lostia, Cannavò, Dario, Minutolo, Giuseppe, Signorelli, Maria, Martinotti, Giovanni, Di Iorio, Giuseppe, Acciavatti, Tiziano, Pallanti, Stefano, Faravelli, Carlo, Altamura, Mario, Stella, Eleonora, Marasco, Daniele, Calcagno, Pietro, Respino, Matteo, Marozzi, Valentina, Riccardi, Ilaria, Collazzoni, Alberto, Stratta, Paolo, Giusti, Laura, Ussorio, Donatella, Delauretis, Ida, Serati, Marta, Caldiroli, Alice, Palazzo, Carlotta, Iasevoli, Felice, Gramaglia, Carla, Gili, Sabrina, Gattoni, Eleonora, Tenconi, Elena, Giannunzio, Valeria, Monaco, Francesco, De Panfilis, Chiara, Camerlengo, Annalisa, Ossola, Paolo, Landi, Paola, Rutigliano, Grazia, Pergentini, Irene, Mauri, Mauro, Di Fabio, Fabio, Torti, Chiara, Buzzanca, Antonino, Comparelli, Anna, De Carolis, Antonella, Corigliano, Valentina, Di Lorenzo, Giorgio, Niolu, Cinzia, Troisi, Alfonso, Corrivetti, Giulio, Pinto, Gaetano, Diasco, Ferdinando, Goracci, Arianna, Bolognesi, Simone, Borghini, Elisa, Montemagni, Cristiana, Frieri, Tiziana, and Birindelli, Nadia

Subjects
medicine.medical_specialty, media_common.quotation_subject, neurocognition, positive symptoms, Context (language use), avolition, Personal resource, Social cognition, Avolition, Disorganization, Engagement with mental health services, Internalized stigma, Neurocognition, Personal resources, Positive symptoms, Real-life functioning, Resilience, Schizophrenia, Psychiatry and Mental Health, Psychiatric Mental Health, medicine, real-life functioning, personal resources, Psychiatry, resilience, Settore MED/25 - Psichiatria, media_common, business.industry, Schizophrenia, avolition, disorganization, engagement with mental health services, internalized stigma, neurocognition, personal resources, positive symptoms, real-life functioning, resilience, disorganization, internalized stigma, engagement with mental health services, Social environment, Research Reports, medicine.disease, Mental health, Psychiatry and Mental health, Psychological resilience, Pshychiatric Mental Health, medicine.symptom, business, Positive symptom, Independent living, Engagement with mental health service
Abstract

In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. The goal of the present study was to identify predictors of real-life functioning in people with schizophrenia, and to assess their relative contribution. Based on previous literature and clinical experience, several factors were selected and grouped into three categories: illness-related variables, personal resources and context-related factors. Some of these variables were never investigated before in relationship with real-life functioning. In 921 patients with schizophrenia living in the community, we found that variables relevant to the disease, personal resources and social context explain 53.8% of real-life functioning variance in a structural equation model. Neurocognition exhibited the strongest, though indirect, association with real-life functioning. Positive symptoms and disorganization, as well as avolition, proved to have significant direct and indirect effects, while depression had no significant association and poor emotional expression was only indirectly and weakly related to real-life functioning. Availability of a disability pension and access to social and family incentives also showed a significant direct association with functioning. Social cognition, functional capacity, resilience, internalized stigma and engagement with mental health services served as mediators. The observed complex associations among investigated predictors, mediators and real-life functioning strongly suggest that integrated and personalized programs should be provided as standard treatment to people with schizophrenia. In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. The goal of the present study was to identify predictors of real-life functioning in people with schizophrenia, and to assess their relative contribution. Based on previous literature and clinical experience, several factors were selected and grouped into three categories: illness-related variables, personal resources and context-related factors. Some of these variables were never investigated before in relationship with real-life functioning. In 921 patients with schizophrenia living in the community, we found that variables relevant to the disease, personal resources and social context explain 53.8% of real-life functioning variance in a structural equation model. Neurocognition exhibited the strongest, though indirect, association with real-life functioning. Positive symptoms and disorganization, as well as avolition, proved to have significant direct and indirect effects, while depression had no significant association and poor emotional expression was only indirectly and weakly related to real-life functioning. Availability of a disability pension and access to social and family incentives also showed a significant direct association with functioning. Social cognition, functional capacity, resilience, internalized stigma and engagement with mental health services served as mediators. The observed complex associations among investigated predictors, mediators and real-life functioning strongly suggest that integrated and personalized programs should be provided as standard treatment to people with schizophrenia.

Published
2014

5. Accuracy of self-assessment of real-life functioning in schizophrenia

Author

Rocca, Paola, Brasso, Claudio, Montemagni, Cristiana, Bellino, Silvio, Rossi, Alessandro, Bertolino, Alessandro, Gibertoni, Dino, Aguglia, Eugenio, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Bucci, Paola, Buzzanca, Antonino, Carpiniello, Bernardo, Cuomo, Alessandro, Dell'Osso, Liliana, Favaro, Angela, Giordano, Giulia Maria, Marchesi, Carlo, Monteleone, Palmiero, Oldani, Lucio, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Galderisi, Silvana, Maj, Mario, Bozzatello, Paola, Badino, Cristina, Giordano, Benedetta, Di Palo, Piergiuseppe, Calia, Vitalba, Papalino, Marco, Barlati, Stefano, Deste, Giacomo, Ceraso, Anna, Pinna, Federica, Olivieri, Benedetta, Manca, Daniela, Piegari, Giuseppe, Brando, Francesco, Giuliani, Luigi, Aiello, Carmen, Fusar Poli, Laura, Concerto, Carmen, Surace, Teresa, Altamura, Mario, Malerba, Stefania, Padalino, Flavia, Calcagno, Pietro, Belvederi Murri, Martino, Amerio, Andrea, Pacitti, Francesca, Socci, Valentina, Lucaselli, Alessia, Giusti, Laura, Salza, Anna, Ussorio, Donatella, Iasevoli, Felice, Gramaglia, Carla, Gambaro, Eleonora, Gattoni, Eleonora, Tenconi, Elena, Collantoni, Enrico, Meneguzzo, Paolo, Ossola, Paolo, Tonna, Matteo, Gerra, Maria Lidia, Carmassi, Claudia, Carpita, Barbara, Cremone, Ivan Mirko, Corrivetti, Giulio, Cascino, Giammarco, Marciello, Francesca, Brugnoli, Roberto, Comparelli, Anna, Corigliano, Valentina, Girardi, Nicoletta, Accinni, Tommaso, Carlone, Luca, Fagiolini, Andrea, Goracci, Arianna, Bolognesi, Simone, Di Lorenzo, Giorgio, Niolu, Cinzia, Ribolsi, Michele, Rocca, P., Brasso, C., Montemagni, C., Bellino, S., Rossi, A., Bertolino, A., Gibertoni, D., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Bucci, P., Buzzanca, A., Carpiniello, B., Cuomo, A., Dell'Osso, L., Favaro, A., Giordano, G. M., Marchesi, C., Monteleone, P., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Galderisi, S., Maj, M., Bozzatello, P., Badino, C., Giordano, B., Di Palo, P., Calia, V., Papalino, M., Barlati, S., Deste, G., Ceraso, A., Pinna, F., Olivieri, B., Manca, D., Piegari, G., Brando, F., Giuliani, L., Aiello, C., Poli, L. F., Concerto, C., Surace, T., Altamura, M., Malerba, S., Padalino, F., Calcagno, P., Murri, M. B., Amerio, A., Pacitti, F., Socci, V., Lucaselli, A., Giusti, L., Salza, A., Ussorio, D., Iasevoli, F., Gramaglia, C., Gambaro, E., Gattoni, E., Tenconi, E., Collantoni, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Carpita, B., Cremone, I. M., Corrivetti, G., Cascino, G., Marciello, F., Brugnoli, R., Comparelli, A., Corigliano, V., Girardi, N., Accinni, T., Carlone, L., Fagiolini, A., Goracci, A., Bolognesi, S., Di Lorenzo, G., Niolu, C., Ribolsi, M., Rocca P., Brasso C., Montemagni C., Bellino S., Rossi A., Bertolino A., Gibertoni D., Aguglia E., Amore M., Andriola I., Bellomo A., Bucci P., Buzzanca A., Carpiniello B., Cuomo A., Dell'Osso L., Favaro A., Giordano G.M., Marchesi C., Monteleone P., Oldani L., Pompili M., Roncone R., Rossi R., Siracusano A., Vita A., Zeppegno P., Galderisi S., Maj M., Bozzatello P., Badino C., Giordano B., Di Palo P., Calia V., Papalino M., Barlati S., Deste G., Ceraso A., Pinna F., Olivieri B., Manca D., Piegari G., Brando F., Giuliani L., Aiello C., Poli L.F., Concerto C., Surace T., Altamura M., Malerba S., Padalino F., Calcagno P., Murri M.B., Amerio A., Pacitti F., Socci V., Lucaselli A., Giusti L., Salza A., Ussorio D., Iasevoli F., Gramaglia C., Gambaro E., Gattoni E., Tenconi E., Collantoni E., Meneguzzo P., Ossola P., Tonna M., Gerra M.L., Carmassi C., Carpita B., Cremone I.M., Corrivetti G., Cascino G., Marciello F., Brugnoli R., Comparelli A., Corigliano V., Girardi N., Accinni T., Carlone L., Fagiolini A., Goracci A., Bolognesi S., Di Lorenzo G., Niolu C., and Ribolsi M.

Subjects
Self-assessment, medicine.medical_treatment, Concordance, RC435-571, schizophrenia, real-life functioning, reliability, Article, Correlation, 03 medical and health sciences, Interpersonal relationship, 0302 clinical medicine, medicine, 030212 general & internal medicine, Self-assessment, schizophrenia, diagnosis, Psychiatry, Rehabilitation, medicine.disease, Psychosis, 030227 psychiatry, Psychiatry and Mental health, Settore MED/25, Schizophrenia, Cohort, Work Skills, Psychology, Clinical psychology
Abstract

A consensus has not yet been reached regarding the accuracy of people with schizophrenia in self-reporting their real-life functioning. In a large (n = 618) cohort of stable, community-dwelling schizophrenia patients we sought to: (1) examine the concordance of patients’ reports of their real-life functioning with the reports of their key caregiver; (2) identify which patient characteristics are associated to the differences between patients and informants. Patient-caregiver concordance of the ratings in three Specific Level of Functioning Scale (SLOF) domains (interpersonal relationships, everyday life skills, work skills) was evaluated with matched-pair t tests, the Lin’s concordance correlation, Somers’ D, and Bland–Altman plots with limits of agreement (LOA). Predictors of the patient-caregiver differences in SLOF ratings were assessed with a linear regression with multivariable fractional polynomials. Patients’ self-evaluation of functioning was higher than caregivers’ in all the evaluated domains of the SLOF and 17.6% of the patients exceeded the LOA, thus providing a self-evaluation discordant from their key caregivers. The strongest predictors of patient-caregiver discrepancies were caregivers’ ratings in each SLOF domain. In clinically stable outpatients with a moderate degree of functional impairment, self-evaluation with the SLOF scale can become a useful, informative and reliable clinical tool to design a tailored rehabilitation program.

Published
2021

6. The interplay among psychopathology, personal resources, context-related factors and real-life functioning in schizophrenia: stability in relationships after 4 years and differences in network structure between recovered and non-recovered patients

Author

Galderisi, Silvana, Rucci, Paola, Mucci, Armida, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Aguglia, Eugenio, Amore, Mario, Bellomo, Antonello, Bozzatello, Paola, Bucci, Paola, Carpiniello, Bernardo, Collantoni, Enrico, Cuomo, Alessandro, Dell'Osso, Liliana, Di Fabio, Fabio, di Giannantonio, Massimo, Gibertoni, Dino, Giordano, Giulia Maria, Marchesi, Carlo, Monteleone, Palmiero, Oldani, Lucio, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Maj, Mario, Italian Network for Research on Psychoses, Francesco, Catapano, Giuseppe, Piegari, Carmen, Aiello, Francesco, Brando, Luigi, Giuliani, Daria, Pietrafesa, Marco, Papalino, Giovanni, Mercadante, Piergiuseppe, Di Palo, Stefano, Barlati, Giacomo, Deste, Paolo, Valsecchi, Federica, Pinna, Benedetta, Olivieri, Daniela, Manca, Maria Salvina, Signorelli, Laura, Fusar Poli, Domenico, De Berardis, Silvia, Fraticelli, Mariangela, Corbo, Stefano, Pallanti, Mario, Altamura, Raffaella, Carnevale, Stefania, Malerba, Pietro, Calcagno, Domenico, Zampogna, Alessandro, Corso, Giusti, Laura, Salza, Anna, Ussorio, Donatella, Talevi, Dalila, Socci, Valentina, Pacitti, Francesca, Andrea, de Bartolomeis, Carla, Gramaglia, Eleonora, Gambaro, Eleonora, Gattoni, Angela, Favaro, Elena, Tenconi, Paolo, Meneguzzo, Matteo, Tonna, Paolo, Ossola, Maria Lidia, Gerra, Claudia, Carmassi, Ivan, Cremone, Barbara, Carpita, Nicoletta, Girardi, Marianna, Frascarelli, Antonio, Buzzanca, Roberto, Brugnoli, Anna, Comparelli, Valentina, Corigliano, Giorgio, Di Lorenzo, Cinzia, Niolu, Michele, Ribolsi, Giulio, Corrivetti, Giammarco, Cascino, Gianfranco, del Buono, Simone, Bolognesi, Andrea, Fagiolini, Arianna, Goracci, Silvio, Bellino, Cristiana, Montemagni, Claudio, Brasso, Galderisi, S., Rucci, P., Mucci, A., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Bozzatello, P., Bucci, P., Carpiniello, B., Collantoni, E., Cuomo, A., Dell'Osso, L., Di Fabio, F., Di Giannantonio, M., Gibertoni, D., Giordano, G. M., Marchesi, C., Monteleone, P., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Maj, M., Catapano, F., Piegari, G., Aiello, C., Brando, F., Giuliani, L., Pietrafesa, D., Papalino, M., Mercadante, G., Di Palo, P., Barlati, S., Deste, G., Valsecchi, P., Pinna, F., Olivieri, B., Manca, D., Signorelli, M. S., Poli, L. F., De Berardis, D., Fraticelli, S., Corbo, M., Pallanti, S., Altamura, M., Carnevale, R., Malerba, S., Calcagno, P., Zampogna, D., Corso, A., Giusti, L., Salza, A., Ussorio, D., Talevi, D., Socci, V., Pacitti, F., de Bartolomeis, A., Gramaglia, C., Gambaro, E., Gattoni, E., Favaro, A., Tenconi, E., Meneguzzo, P., Tonna, M., Ossola, P., Gerra, M. L., Carmassi, C., Cremone, I., Carpita, B., Girardi, N., Frascarelli, M., Buzzanca, A., Brugnoli, R., Comparelli, A., Corigliano, V., Di Lorenzo, G., Niolu, C., Ribolsi, M., Corrivetti, G., Cascino, G., Del Buono, G., Bolognesi, S., Fagiolini, A., Goracci, A., Bellino, S., Montemagni, C., Brasso, C., di Giannantonio, M., Fusar Poli, L., del Buono, G., Galderisi S., Rucci P., Mucci A., Rossi A., Rocca P., Bertolino A., Aguglia E., Amore M., Bellomo A., Bozzatello P., Bucci P., Carpiniello B., Collantoni E., Cuomo A., Dell'osso L., Di Fabio F., Di Giannantonio M., Gibertoni D., Giordano G.M., Marchesi C., Monteleone P., Oldani L., Pompili M., Roncone R., Rossi R., Siracusano A., Vita A., Zeppegno P., Maj M., Catapano F., Piegari G., Aiello C., Brando F., Giuliani L., Pietrafesa D., Papalino M., Mercadante G., Di Palo P., Barlati S., Deste G., Valsecchi P., Pinna F., Olivieri B., Manca D., Signorelli M.S., Poli L.F., De Berardis D., Fraticelli S., Corbo M., Pallanti S., Altamura M., Carnevale R., Malerba S., Calcagno P., Zampogna D., Corso A., Giusti L., Salza A., Ussorio D., Talevi D., Socci V., Pacitti F., de Bartolomeis A., Gramaglia C., Gambaro E., Gattoni E., Favaro A., Tenconi E., Meneguzzo P., Tonna M., Ossola P., Gerra M.L., Carmassi C., Cremone I., Carpita B., Girardi N., Frascarelli M., Buzzanca A., Brugnoli R., Comparelli A., Corigliano V., Di Lorenzo G., Niolu C., Ribolsi M., Corrivetti G., Cascino G., Del Buono G., Bolognesi S., Fagiolini A., Goracci A., Bellino S., Montemagni C., and Brasso C.

Subjects
Schizophrenia, everyday life skills, functional capacity, internalized stigma, network analysis, personal resources, psychopathology, real-life functioning, recovery, Closeness, Context (language use), 03 medical and health sciences, 0302 clinical medicine, Betweenness centrality, medicine, network analysi, Everyday life, Baseline (configuration management), personal resource, Research Reports, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Settore MED/25, everyday life skill, Pshychiatric Mental Health, Psychology, Centrality, 030217 neurology & neurosurgery, Psychopathology, Clinical psychology
Abstract

Improving real-life functioning is the main goal of the most advanced integrated treatment programs in people with schizophrenia. The Italian Network for Research on Psychoses previously explored, by using network analysis, the interplay among illness-related variables, personal resources, context-related factors and real-life functioning in a large sample of patients with schizophrenia. The same research network has now completed a 4-year follow-up of the original sample. In the present study, we used network analysis to test whether the pattern of relationships among all variables investigated at baseline was similar at follow-up. In addition, we compared the network structure of patients who were classified as recovered at follow-up versus those who did not recover. Six hundred eighteen subjects recruited at baseline could be assessed in the follow-up study. The network structure did not change significantly from baseline to follow-up, and the overall strength of the connections among variables increased slightly, but not significantly. Functional capacity and everyday life skills had a high betweenness and closeness in the network at follow-up, as they had at baseline, while psychopathological variables remained more peripheral. The network structure and connectivity of non-recovered patients were similar to those observed in the whole sample, but very different from those in recovered subjects, in which we found few connections only. These data strongly suggest that tightly coupled symptoms/dysfunctions tend to maintain each other's activation, contributing to poor outcome in schizophrenia. Early and integrated treatment plans, targeting variables with high centrality, might prevent the emergence of self-reinforcing networks of symptoms and dysfunctions in people with schizophrenia.

Published
2020

7. Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition

Author

Bucci, P., Galderisi, S., Mucci, A., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Biondi, M., Cuomo, A., Dell'Osso, L., Favaro, A., Gambi, F., Giordano, G. M., Girardi, P., Marchesi, C., Monteleone, P., Montemagni, C., Niolu, C., Oldani, L., Pacitti, F., Pinna, F., Roncone, R., Vita, A., Zeppegno, P., Maj, M., Patriarca, Sara, Pietrafesa, Daria, Aiello, Carmen, Longo, Luisa, Barone, Marina, Romano, Raffaella, Atti, Anna Rita, Barlati, Stefano, Deste, Giacomo, Valsecchi, Paolo, Carpiniello, Bernardo, Tusconi, Massimo, Puddu, Laura, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Corbo, Mariangela, Montemitro, Chiara, Baroni, Gaia, Altamura, Mario, La Montagna, Maddalena, Carnevale, Raffaella, Murri, Martino Belvederi, Calcagno, Pietro, Bugliani, Michele, Pizziconi, Giulia, Logozzo, Francesca, Rossi, Rodolfo, Giusti, Laura, Salza, Anna, Malavolta, Maurizio, Orsenigo, Giulia, Grassi, Silvia, De Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Gambaro, Eleonora, Tenconi, Elena, Ferronato, Luisa, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Carmassi, Claudia, Cremone, Ivan Mirko, Carpita, Barbara, Buzzanca, Antonio, Girardi, Nicoletta, Frascarelli, Marianna, Del Casale, Antonio, Comparelli, Anna, Corigliano, Valentina, Siracusano, Alberto, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Del Buono, Gianfranco, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Mancini, Irene, Bava, Irene, Cardillo, Simona, Bucci P., Galderisi S., Mucci A., Rossi A., Rocca P., Bertolino A., Aguglia E., Amore M., Andriola I., Bellomo A., Biondi M., Cuomo A., dell'Osso L., Favaro A., Gambi F., Giordano G.M., Girardi P., Marchesi C., Monteleone P., Montemagni C., Niolu C., Oldani L., Pacitti F., Pinna F., Roncone R., Vita A., Zeppegno P., Maj M., Patriarca S., Pietrafesa D., Aiello C., Longo L., Barone M., Romano R., Atti A.R., Barlati S., Deste G., Valsecchi P., Carpiniello B., Tusconi M., Puddu L., Signorelli M.S., Cannavo D., Minutolo G., Corbo M., Montemitro C., Baroni G., Altamura M., La Montagna M., Carnevale R., Murri M.B., Calcagno P., Bugliani M., Pizziconi G., Logozzo F., Rossi R., Giusti L., Salza A., Malavolta M., Orsenigo G., Grassi S., De Bartolomeis A., Gramaglia C., Gattoni E., Gambaro E., Tenconi E., Ferronato L., Collantoni E., Tonna M., Ossola P., Gerra M.L., Carmassi C., Cremone I.M., Carpita B., Buzzanca A., Girardi N., Frascarelli M., Del Casale A., Comparelli A., Corigliano V., Siracusano A., Di Lorenzo G., Ribolsi M., Corrivetti G., Bartoli L., Del Buono G., Fagiolini A., Bolognesi S., Goracci A., Mancini I., Bava I., Cardillo S., Bucci, P., Galderisi, S., Mucci, A., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Biondi, Maria, Cuomo, Anna, Dell'Osso, L., Favaro, A., Gambi, F., Giordano, G. M., Girardi, P., Marchesi, C., Monteleone, P., Montemagni, C., Niolu, C., Oldani, L., Pacitti, F., Pinna, F., Roncone, R., DE VITA, Anna, Zeppegno, P., Maj, M., Patriarca, Sara, Pietrafesa, Daria, Aiello, Carmen, Longo, Luisa, Barone, Marina, Romano, Raffaella, Atti, Anna Rita, Barlati, Stefano, Deste, Giacomo, Valsecchi, Paolo, Carpiniello, Bernardo, Tusconi, Massimo, Puddu, Laura, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Corbo, Mariangela, Montemitro, Chiara, Baroni, Gaia, Altamura, Mario, La Montagna, Maddalena, Carnevale, Raffaella, Murri, Martino Belvederi, Calcagno, Pietro, Bugliani, Michele, Pizziconi, Giulia, Logozzo, Francesca, Rossi, Rodolfo, Giusti, Laura, Salza, Anna, Malavolta, Maurizio, Orsenigo, Giulia, Grassi, Silvia, De Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Gambaro, Eleonora, Tenconi, Elena, Ferronato, Luisa, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Carmassi, Claudia, Cremone, Ivan Mirko, Carpita, Barbara, Buzzanca, Antonio, Girardi, Nicoletta, Frascarelli, Marianna, Del Casale, Antonio, Comparelli, Anna, Corigliano, Valentina, Siracusano, Alberto, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Del Buono, Gianfranco, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Mancini, Irene, Bava, Irene, Cardillo, Simona, Biondi, M., Cuomo, A., Vita, A., and Casale, Antonio

Subjects
Male, avolition, Severity of Illness Index, cognitive functioning, 0302 clinical medicine, Cognition, Academic Performance, Medicine, Psychopathology, Depression, primary negative symptoms, Middle Aged, Psychiatric Status Rating Scale, avolition, cognitive functioning, poor emotion expression, premorbid adjustment, primary negative symptoms, poor emotion expression, premorbid adjustment, Psychiatry and Mental Health, Memory, Short-Term, Schizophrenia, Female, Schizophrenic Psychology, medicine.symptom, Psychosocial, Social Adjustment, Clinical psychology, Human, Adult, primary negative symptom, 03 medical and health sciences, Cognition Disorder, Memory, Social cognition, Humans, Cognitive Dysfunction, Cognitive skill, Social Behavior, Aged, Cognition Disorders, Motivation, Psychiatric Status Rating Scales, Settore MED/25 - Psichiatria, Avolition, business.industry, medicine.disease, 030227 psychiatry, Short-Term, business, Neurocognitive, 030217 neurology & neurosurgery
Abstract

Objective The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. Method Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored. Results We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001). Conclusion Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs.

Published
2018

8. Social cognition in people with schizophrenia: a cluster-analytic approach

Author

Rocca, P., Galderisi, S., Rossi, A., Bertolino, A., Rucci, P., Gibertoni, D., Montemagni, C., Sigaudo, M., Mucci, A., Bucci, P., Acciavatti, T., Aguglia, E., Amore, M., Bellomo, A., Deronchi, D., Osso, L., Difabio, F., Girardi, P., Goracci, A., Marchesi, C., Monteleone, P., Niolu, C., Pinna, F., Roncone, R., EMILIO SACCHETTI, Santonastaso, P., Zeppegno, P., Maj, M., Chieffi, M., Piegari, M., Vignapiano, A., Merlotti, E., Plescia, G., Montefusco, V., Bava, I., Mancini, I., Sandei, L., Antoniettanettis, I., Rizzo, G., Mancini, M., Porcelli, S., Salfi, G., Bianchini, O., Antonio Vita, Galluzzo, G., Barlati, S., Carpiniello, B., Primavera, D., Floris, S., Salvina, Signorelli, Minutolo, B., Cannavò, G., Corbo, D., Vellante, M., Alessandrini, F., Poli, M., Altamura, M., Petito, M., Marasco, A., Vaggi, D., Calcagno, M., Marozzi, P., Ussorio, V., Giusti, D., Malavolta, L., Diemidio, M., Stratta, G., Collazzoni, P., Debartolomeis, P., Gramaglia, P., Gili, C., Gattoni, S., Ferronato, E., Giannunzio, L., Tenconi, V., Tonna, E., Ossola, M., Camerlengo, P., Landi, E., Rutigliano, P., Buzzanca, G., Paolemili, A., Frascarelli, M., Comparelli, M., Corigliano, A., Brugnoli, V., Siracusano, R., Troisi, A., Dilorenzo, A., Filippo, Di, Longobardi, C., Castaldo, N., Fagiolini, E., Bolognesi, A., Capua, De, A, DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche, Da definire, Rocca, P, Galderisi, S., Rossi, A., Bertolino, A., Rucci, P., Gibertoni, D., Montemagni, C., Sigaudo, M., Mucci, A., Bucci, P., Acciavatti, T., Aguglia, E., Amore, M., Bellomo, A., De Ronchi, D., Dell'Osso, L., Di Fabio, F., Girardi, P., Goracci, A., Marchesi, C., Monteleone, P., Niolu, C., Pinna, F., Roncone, R., Sacchetti, E., Santonastaso, P., Zeppegno, P., Maj, M., Rocca, P., Chieffi, M., Piegari, M., Vignapiano, A., Merlotti, E., Plescia, G., Montefusco, V., Bava, I., Mancini, I., Sandei, L., Antonietta Nettis, I., Rizzo, G., Mancini, M., Porcelli, S., Salfi, G., Bianchini, O., Vita, A., Galluzzo, G., Barlati, S., Carpiniello, B., Primavera, D., Floris, S., Salvina Signorelli, B., Minutolo, G., Cannavo, D., Corbo, M., Vellante, F., Alessandrini, M., Poli, M., Altamura, M., Petito, A., Marasco, D., Vaggi, M., Calcagno, P., Marozzi, V., Ussorio, D., Giusti, L., Malavolta, M., Di Emidio, G., Stratta, P., Collazzoni, P., De Bartolomeis, P., Gramaglia, C., Gili, S., Gattoni, E., Ferronato, L., Giannunzio, V., Tenconi, E., Tonna, M., Ossola, P., Camerlengo, E., Landi, P., Rutigliano, G., Buzzanca, A., Paolemili, M., Frascarelli, M., Comparelli, A., Corigliano, V., Brugnoli, R., Siracusano, A., Troisi, A., Di Lorenzo, G., Di Filippo, C., Longobardi, N., Castaldo, E., Fagiolini, A., Bolognesi, S., De Capua, A., and Italian Network for Research on, Psychoses

Subjects
Adult, Male, Context (language use), social cognition, Italian Network for Research on Psychoses, 03 medical and health sciences, 0302 clinical medicine, Cluster analysis, Social cognition, Emotion perception, medicine, schizophrenia, theory of mind, Cluster Analysis, Emotional Intelligence, Facial Recognition, Female, Humans, Middle Aged, Schizophrenia, Facial Expression, Social Perception, Wit and Humor as Topic, Applied Psychology, Psychiatry and Mental Health, Cluster analysis Italian Network for Research on Psychosesschizophrenia social cognition theory of mind, Cluster analysi, Italian Network for Research on Psychose, Settore MED/25 - Psichiatria, Facial expression, Social perception, Emotional intelligence, medicine.disease, cluster analysis, italian network for research on psychoses, adult, emotional intelligence, facial recognition, female, humans, male, middle aged, facial expression, social perception, wit and humor as topic, applied psychology, psychiatry and mental health, 030227 psychiatry, Psychology, Neurocognitive, 030217 neurology & neurosurgery, Clinical psychology
Abstract

none 28 no BACKGROUND: The study aimed to subtype patients with schizophrenia on the basis of social cognition (SC), and to identify cut-offs that best discriminate among subtypes in 809 out-patients recruited in the context of the Italian Network for Research on Psychoses. METHOD: A two-step cluster analysis of The Awareness of Social Inference Test (TASIT), the Facial Emotion Identification Test and Mayer-Salovey-Caruso Emotional Intelligence Test scores was performed. Classification and regression tree analysis was used to identify the cut-offs of variables that best discriminated among clusters. RESULTS: We identified three clusters, characterized by unimpaired (42%), impaired (50.4%) and very impaired (7.5%) SC. Three theory-of-mind domains were more important for the cluster definition as compared with emotion perception and emotional intelligence. Patients more able to understand simple sarcasm (⩾14 for TASIT-SS) were very likely to belong to the unimpaired SC cluster. Compared with patients in the impaired SC cluster, those in the very impaired SC cluster performed significantly worse in lie scenes (TASIT-LI

Published
2016

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