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4 results on '"Esezobor, C"'

1. Systolic blood pressure of Nigerian children with sickle cell disease

Author

Onifade E,, Esezobor C I, and Banwo, T

Subjects
Medicine
Abstract

Background: Blood pressure readings of adult Nigerians with sickle cell disease (SCD) are reported to be lower than that of the general population but similar studies in children are unavailable. Objectives: To determine the systolic blood pressure (SBP) of children with SCD and compare it with that of healthy controls. Also, to correlate the SBP of children with SCD with age, gender, height and weight. Methods: Children with SCD were recruited from the Paediatric Haematology Clinic of the Lagos University Teaching Hospital. Data collected included bio-demographic details, social classification, height and weight measurements and present clinical status. SBP was measured using a Doppler (VASCUTRACK 120®) and a mercury sphygmomanometer. Similar data were obtained from age and sex matched apparently healthy children. Results: One hundred and twenty three children with SCD and 62 apparently healthy controls were studied; 62% were females. The mean age of the children with SCD was 8.93±3.91years (range 1-17 years) and was similar to the controls. SBP was similar in both groups of children (90.9±12.7 versus 92.2±15.2 mmHg; p=0.53) and increased with age. In 91 (74%) children with SCD the SBP was below the 50th centile for the general population. Multiple linear regressions involving sex, age, height and weight found no independent factor to be a significant predictor of the SBP in children with SCD. Conclusion: The SBP of children with SCD is similar to that of age and sex-matched controls. The sex, age, weight and height did not significantly predict SBP in multiple linear regression.

Published
2024

2. Anthropometric measurements of HIV-infected children aged one to five years in a tertiary hospital in Lagos Nigeria

Author

Akintan PE, Akinsulie AO, Temiye E, and Esezobor C

Subjects
hiv, children, weight, height, muac, head circumference, Medicine
Abstract

Objectives: To determine the association between HIV infection and anthropometric measures (weight, height, midupper arm circumference and head circumference) of children aged one to five years. Method: A cross sectional descriptive study using structured questionnaire and measurement of weight, height, head and midupper arm circumference of 846 infected children and matched controls. Results: The mean weights of the controls were significantly higher than those of the infected children at all age groups (p

Published
2024

3. Management of community acquired pneumonia (CAP) in children: Clinical practice guidelines by the Paediatrics Association of Nigeria (PAN)

Author

Olowu A, Elushiyan JBE, Esangbedo D, Ekure EN, Esezobor C, Falade AG, Osinusi K, Mukhtar-Yola M, Meremikwu M, Ibe B, Johnson WBR, Oviawe O, and Bastos I

Subjects
Medicine
Abstract

Against the background of the subsisting high childhood mortality indices in Nigeria, vis-a-vis the global efforts in the last 10 years to stem the tide (as articulated in the Millennium Development Goals), there has been a corresponding need to address the common causes of deaths in under- fives. In Nigeria, as is the case in many countries in DOI:http://dx.doi.org/10.4314/njp.v42i4.1 sub-Saharan Africa, pneumonia remains a common cause of under-five mortality, accounting for 17% of deaths in this age-group. Indeed, it has been estimated that globally, a child dies from pneumonia every 20 seconds. With these in mind, and indeed the laudable goal of a 66% reduction of the national under-five deaths by the year 2015, a prompt recognition and management of pneumonia (in this vulnerable paediatric population) has become imperative. This was the logic that informed the current initiative of the Paediatric Association of Nigeria, aimed at formulating diagnostic, treatment and control policies with respect to paediatric community acquired pneumonia (CAP). This document is targeted primarily at health care providers working in Nigeria in centres with limited facilities as well as those working in tertiary hospitals.

Published
2024

4. Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the global burden of disease study 2020, release 1

Author

Galles N. C., Liu P. Y., Updike R. L., Fullman N., Nguyen J., Rolfe S., Sbarra A. N., Schipp M. F., Marks A., Abady G. G., Abbas K. M., Abbasi S. W., Abbastabar H., Abd-Allah F., Abdoli A., Abolhassani H., Abosetugn A. E., Adabi M., Adamu A. A., Adetokunboh O. O., Adnani Q. E. S., Advani S. M., Afzal S., Aghamir S. M. K., Ahinkorah B. O., Ahmad S., Ahmad T., Ahmadi S., Ahmed H., Ahmed M. B., Ahmed Rashid T., Ahmed Salih Y., Akalu Y., Aklilu A., Akunna C. J., Al Hamad H., Alahdab F., Albano L., Alemayehu Y., Alene K. A., Al-Eyadhy A., Alhassan R. K., Ali L., Aljunid S. M., Almustanyir S., Altirkawi K. A., Alvis-Guzman N., Amu H., Andrei C. L., Andrei T., Ansar A., Ansari-Moghaddam A., Antonazzo I. C., Antony B., Arabloo J., Arab-Zozani M., Artanti K. D., Arulappan J., Awan A. T., Awoke M. A., Ayza M. A., Azarian G., Azzam A. Y., B D. B., Babar Z. -U. -D., Balakrishnan S., Banach M., Bante S. A., Barnighausen T. W., Barqawi H. J., Barrow A., Bassat Q., Bayarmagnai N., Bejarano Ramirez D. F., Bekuma T. T., Belay H. G., Belgaumi U. I., Bhagavathula A. S., Bhandari D., Bhardwaj N., Bhardwaj P., Bhaskar S., Bhattacharyya K., Bibi S., Bijani A., Biondi A., Boloor A., Braithwaite D., Buonsenso D., Butt Z. A., Camargos P., Carreras G., Carvalho F., Castaneda-Orjuela C. A., Chakinala R. C., Charan J., Chatterjee S., Chattu S. K., Chattu V. K., Chowdhury F. R., Christopher D. J., Chu D. -T., Chung S. -C., Cortesi P. A., Costa V. M., Couto R. A. S., Dadras O., Dagnew A. B., Dagnew B., Dai X., Dandona L., Dandona R., De Neve J. -W., Derbew Molla M., Derseh B. T., Desai R., Desta A. A., Dhamnetiya D., Dhimal M. L., Dhimal M., Dianatinasab M., Diaz D., Djalalinia S., Dorostkar F., Edem B., Edinur H. A., Eftekharzadeh S., El Sayed I., El Sayed Zaki M., Elhadi M., El-Jaafary S. I., Elsharkawy A., Enany S., Erkhembayar R., Esezobor C. I., Eskandarieh S., Ezeonwumelu I. J., Ezzikouri S., Fares J., Faris P. S., Feleke B. E., Ferede T. Y., Fernandes E., Fernandes J. C., Ferrara P., Filip I., Fischer F., Francis M. R., Fukumoto T., Gad M. M., Gaidhane S., Gallus S., Garg T., Geberemariyam B. S., Gebre T., Gebregiorgis B. G., Gebremedhin K. B., Gebremichael B., Gessner B. D., Ghadiri K., Ghafourifard M., Ghashghaee A., Gilani S. A., Glavan I. -R., Glushkova E. V., Golechha M., Gonfa K. B., Gopalani S. V., Goudarzi H., Gubari M. I. M., Guo Y., Gupta V. B., Gupta V. K., Gutierrez R. A., Haeuser E., Halwani R., Hamidi S., Hanif A., Haque S., Harapan H., Hargono A., Hashi A., Hassan S., Hassanein M. H., Hassanipour S., Hassankhani H., Hay S. I., Hayat K., Hegazy M. I., Heidari G., Hezam K., Holla R., Hoque M. E., Hosseini M., Hosseinzadeh M., Hostiuc M., Househ M., Hsieh V. C. -R., Huang J., Humayun A., Hussain R., Hussein N. R., Ibitoye S. E., Ilesanmi O. S., Ilic I. M., Ilic M. D., Inamdar S., Iqbal U., Irham L. M., Irvani S. S. N., Islam S. M. S., Ismail N. E., Itumalla R., Jha R. P., Joukar F., Kabir A., Kabir Z., Kalhor R., Kamal Z., Kamande S. M., Kandel H., Karch A., Kassahun G., Kassebaum N. J., Katoto P. D., Kelkay B., Kengne A. P., Khader Y. S., Khajuria H., Khalil I. A., Khan E. A., Khan G., Khan J., Khan M., Khan M. A., Khang Y. -H., Khoja A. T., Khubchandani J., Kim G. R., Kim M. S., Kim Y. J., Kimokoti R. W., Kisa A., Kisa S., Korshunov V. A., Kosen S., Kuate Defo B., Kulkarni V., Kumar A., Kumar G. A., Kumar N., Kwarteng A., La Vecchia C., Lami F. H., Landires I., Lasrado S., Lassi Z. S., Lee H., Lee Y. Y., Levi M., Lewycka S., Li S., Liu X., Lobo S. W., Lopukhov P. D., Lozano R., Lutzky Saute R., Magdy Abd El Razek M., Makki A., Malik A. A., Mansour-Ghanaei F., Mansournia M. A., Mantovani L. G., Martins-Melo F. R., Matthews P. C., Medina J. R. C., Mendoza W., Menezes R. G., Mengesha E. W., Meretoja T. J., Mersha A. G., Mesregah M. K., Mestrovic T., Miazgowski B., Milne G. J., Mirica A., Mirrakhimov E. M., Mirzaei H. R., Misra S., Mithra P., Moghadaszadeh M., Mohamed T. A., Mohammad K. A., Mohammad Y., Mohammadi M., Mohammadian-Hafshejani A., Mohammed A., Mohammed S., Mohapatra A., Mokdad A. H., Molokhia M., Monasta L., Moni M. A., Montasir A. A., Moore C. E., Moradi G., Moradzadeh R., Moraga P., Mueller U. O., Munro S. B., Naghavi M., Naimzada M. D., Naveed M., Nayak B. P., Negoi I., Neupane Kandel S., Nguyen T. H., Nikbakhsh R., Ningrum D. N. A., Nixon M. R., Nnaji C. A., Noubiap J. J., Nunez-Samudio V., Nwatah V. E., Oancea B., Ochir C., Ogbo F. A., Olagunju A. T., Olakunde B. O., Onwujekwe O. E., Otstavnov N., Otstavnov S. S., Owolabi M. O., Padubidri J. R., Pakshir K., Park E. -C., Pashazadeh Kan F., Pathak M., Paudel R., Pawar S., Pereira J., Peres M. F. P., Perianayagam A., Pinheiro M., Pirestani M., Podder V., Polibin R. V., Pollok R. C. G., Postma M. J., Pottoo F. H., Rabiee M., Rabiee N., Radfar A., Rafiei A., Rahimi-Movaghar V., Rahman M., Rahmani A. M., Rahmawaty S., Rajesh A., Ramshaw R. E., Ranasinghe P., Rao C. R., Rao S. J., Rathi P., Rawaf D. L., Rawaf S., Renzaho A. M. N., Rezaei N., Rezai M. S., Rios-Blancas M., Rogowski E. L. B., Ronfani L., Rwegerera G. M., Saad A. M., Sabour S., Saddik B., Saeb M. R., Saeed U., Sahebkar A., Sahraian M. A., Salam N., Salimzadeh H., Samaei M., Samy A. M., Sanabria J., Sanmarchi F., Santric-Milicevic M. M., Sartorius B., Sarveazad A., Sathian B., Sawhney M., Saxena D., Saxena S., Seidu A. -A., Seylani A., Shaikh M. A., Shamsizadeh M., Shetty P. H., Shigematsu M., Shin J. I., Sidemo N. B., Singh A., Singh J. A., Sinha S., Skryabin V. Y., Skryabina A. A., Soheili A., Tadesse E. G., Tamiru A. T., Tan K. -K., Tekalegn Y., Temsah M. -H., Thakur B., Thapar R., Thavamani A., Tobe-Gai R., Tohidinik H. R., Tovani-Palone M. R., Traini E., Tran B. X., Tripathi M., Tsegaye B., Tsegaye G. W., Ullah A., Ullah S., Unim B., Vacante M., Velazquez D. Z., Vo B., Vollmer S., Vu G. T., Vu L. G., Waheed Y., Winkler A. S., Wiysonge C. S., Yigit V., Yirdaw B. W., Yon D. K., Yonemoto N., Yu C., Yuce D., Yunusa I., Zamani M., Zamanian M., Zewdie D. T., Zhang Z. -J., Zhong C., Zumla A., Murray C. J. L., Lim S. S., Mosser J. F., Aghamir S., Sahraian M., Mansournia M., Mirzaei H., Temsah M., Andrei C., Glavan I., Antonazzo I., Singh Mtech A., Padubidri J., Babar Z., De Neve J., Noubiap J., Chakinala R., Chattu S., Chattu V., Chu D., Chung S., Kumar G., Gilani S., Gupta V., Hargono Dr A., Islam S., Hsieh V., Irvani S. N., Ismail N., Khang Y., Yon D., Kim G., Park E., Shin J., Kim M., Kim Y., Lee Y., Medina J. C., Naimzada M., Rahmani A., Rezai M., Rao S., Saeb M., Seidu A., Tan K., Tohidinik H., Zhang Z., Galles, N, Liu, P, Updike, R, Fullman, N, Nguyen, J, Rolfe, S, Sbarra, A, Schipp, M, Marks, A, Abady, G, Abbas, K, Abbasi, S, Abbastabar, H, Abd-Allah, F, Abdoli, A, Abolhassani, H, Abosetugn, A, Adabi, M, Adamu, A, Adetokunboh, O, Adnani, Q, Advani, S, Afzal, S, Aghamir, S, Ahinkorah, B, Ahmad, S, Ahmad, T, Ahmadi, S, Ahmed, H, Ahmed, M, Ahmed Rashid, T, Ahmed Salih, Y, Akalu, Y, Aklilu, A, Akunna, C, Al Hamad, H, Alahdab, F, Albano, L, Alemayehu, Y, Alene, K, Al-Eyadhy, A, Alhassan, R, Ali, L, Aljunid, S, Almustanyir, S, Altirkawi, K, Alvis-Guzman, N, Amu, H, Andrei, C, Andrei, T, Ansar, A, Ansari-Moghaddam, A, Antonazzo, I, Antony, B, Arabloo, J, Arab-Zozani, M, Artanti, K, Arulappan, J, Awan, A, Awoke, M, Ayza, M, Azarian, G, Azzam, A, B, D, Babar, Z, Balakrishnan, S, Banach, M, Bante, S, Barnighausen, T, Barqawi, H, Barrow, A, Bassat, Q, Bayarmagnai, N, Bejarano Ramirez, D, Bekuma, T, Belay, H, Belgaumi, U, Bhagavathula, A, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhaskar, S, Bhattacharyya, K, Bibi, S, Bijani, A, Biondi, A, Boloor, A, Braithwaite, D, Buonsenso, D, Butt, Z, Camargos, P, Carreras, G, Carvalho, F, Castaneda-Orjuela, C, Chakinala, R, Charan, J, Chatterjee, S, Chattu, S, Chattu, V, Chowdhury, F, Christopher, D, Chu, D, Chung, S, Cortesi, P, Costa, V, Couto, R, Dadras, O, Dagnew, A, Dagnew, B, Dai, X, Dandona, L, Dandona, R, De Neve, J, Derbew Molla, M, Derseh, B, Desai, R, Desta, A, Dhamnetiya, D, Dhimal, M, Dianatinasab, M, Diaz, D, Djalalinia, S, Dorostkar, F, Edem, B, Edinur, H, Eftekharzadeh, S, El Sayed, I, El Sayed Zaki, M, Elhadi, M, El-Jaafary, S, Elsharkawy, A, Enany, S, Erkhembayar, R, Esezobor, C, Eskandarieh, S, Ezeonwumelu, I, Ezzikouri, S, Fares, J, Faris, P, Feleke, B, Ferede, T, Fernandes, E, Fernandes, J, Ferrara, P, Filip, I, Fischer, F, Francis, M, Fukumoto, T, Gad, M, Gaidhane, S, Gallus, S, Garg, T, Geberemariyam, B, Gebre, T, Gebregiorgis, B, Gebremedhin, K, Gebremichael, B, Gessner, B, Ghadiri, K, Ghafourifard, M, Ghashghaee, A, Gilani, S, Glavan, I, Glushkova, E, Golechha, M, Gonfa, K, Gopalani, S, Goudarzi, H, Gubari, M, Guo, Y, Gupta, V, Gutierrez, R, Haeuser, E, Halwani, R, Hamidi, S, Hanif, A, Haque, S, Harapan, H, Hargono, A, Hashi, A, Hassan, S, Hassanein, M, Hassanipour, S, Hassankhani, H, Hay, S, Hayat, K, Hegazy, M, Heidari, G, Hezam, K, Holla, R, Hoque, M, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Househ, M, Hsieh, V, Huang, J, Humayun, A, Hussain, R, Hussein, N, Ibitoye, S, Ilesanmi, O, Ilic, I, Ilic, M, Inamdar, S, Iqbal, U, Irham, L, Irvani, S, Islam, S, Ismail, N, Itumalla, R, Jha, R, Joukar, F, Kabir, A, Kabir, Z, Kalhor, R, Kamal, Z, Kamande, S, Kandel, H, Karch, A, Kassahun, G, Kassebaum, N, Katoto, P, Kelkay, B, Kengne, A, Khader, Y, Khajuria, H, Khalil, I, Khan, E, Khan, G, Khan, J, Khan, M, Khang, Y, Khoja, A, Khubchandani, J, Kim, G, Kim, M, Kim, Y, Kimokoti, R, Kisa, A, Kisa, S, Korshunov, V, Kosen, S, Kuate Defo, B, Kulkarni, V, Kumar, A, Kumar, G, Kumar, N, Kwarteng, A, La Vecchia, C, Lami, F, Landires, I, Lasrado, S, Lassi, Z, Lee, H, Lee, Y, Levi, M, Lewycka, S, Li, S, Liu, X, Lobo, S, Lopukhov, P, Lozano, R, Lutzky Saute, R, Magdy Abd El Razek, M, Makki, A, Malik, A, Mansour-Ghanaei, F, Mansournia, M, Mantovani, L, Martins-Melo, F, Matthews, P, Medina, J, Mendoza, W, Menezes, R, Mengesha, E, Meretoja, T, Mersha, A, Mesregah, M, Mestrovic, T, Miazgowski, B, Milne, G, Mirica, A, Mirrakhimov, E, Mirzaei, H, Misra, S, Mithra, P, Moghadaszadeh, M, Mohamed, T, Mohammad, K, Mohammad, Y, Mohammadi, M, Mohammadian-Hafshejani, A, Mohammed, A, Mohammed, S, Mohapatra, A, Mokdad, A, Molokhia, M, Monasta, L, Moni, M, Montasir, A, Moore, C, Moradi, G, Moradzadeh, R, Moraga, P, Mueller, U, Munro, S, Naghavi, M, Naimzada, M, Naveed, M, Nayak, B, Negoi, I, Neupane Kandel, S, Nguyen, T, Nikbakhsh, R, Ningrum, D, Nixon, M, Nnaji, C, Noubiap, J, Nunez-Samudio, V, Nwatah, V, Oancea, B, Ochir, C, Ogbo, F, Olagunju, A, Olakunde, B, Onwujekwe, O, Otstavnov, N, Otstavnov, S, Owolabi, M, Padubidri, J, Pakshir, K, Park, E, Pashazadeh Kan, F, Pathak, M, Paudel, R, Pawar, S, Pereira, J, Peres, M, Perianayagam, A, Pinheiro, M, Pirestani, M, Podder, V, Polibin, R, Pollok, R, Postma, M, Pottoo, F, Rabiee, M, Rabiee, N, Radfar, A, Rafiei, A, Rahimi-Movaghar, V, Rahman, M, Rahmani, A, Rahmawaty, S, Rajesh, A, Ramshaw, R, Ranasinghe, P, Rao, C, Rao, S, Rathi, P, Rawaf, D, Rawaf, S, Renzaho, A, Rezaei, N, Rezai, M, Rios-Blancas, M, Rogowski, E, Ronfani, L, Rwegerera, G, Saad, A, Sabour, S, Saddik, B, Saeb, M, Saeed, U, Sahebkar, A, Sahraian, M, Salam, N, Salimzadeh, H, Samaei, M, Samy, A, Sanabria, J, Sanmarchi, F, Santric-Milicevic, M, Sartorius, B, Sarveazad, A, Sathian, B, Sawhney, M, Saxena, D, Saxena, S, Seidu, A, Seylani, A, Shaikh, M, Shamsizadeh, M, Shetty, P, Shigematsu, M, Shin, J, Sidemo, N, Singh, A, Singh, J, Sinha, S, Skryabin, V, Skryabina, A, Soheili, A, Tadesse, E, Tamiru, A, Tan, K, Tekalegn, Y, Temsah, M, Thakur, B, Thapar, R, Thavamani, A, Tobe-Gai, R, Tohidinik, H, Tovani-Palone, M, Traini, E, Tran, B, Tripathi, M, Tsegaye, B, Tsegaye, G, Ullah, A, Ullah, S, Unim, B, Vacante, M, Velazquez, D, Vo, B, Vollmer, S, Vu, G, Vu, L, Waheed, Y, Winkler, A, Wiysonge, C, Yigit, V, Yirdaw, B, Yon, D, Yonemoto, N, Yu, C, Yuce, D, Yunusa, I, Zamani, M, Zamanian, M, Zewdie, D, Zhang, Z, Zhong, C, Zumla, A, Murray, C, Lim, S, Mosser, J, Singh Mtech, A, Hargono Dr, A, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), Tampere University, Health Sciences, HUS Comprehensive Cancer Center, University of Helsinki, Helsinki University Hospital Area, Abbas, Kaja [0000-0003-0563-1576], Veritati - Repositório Institucional da Universidade Católica Portuguesa, and GBD 2020, Release 1, Vaccine Coverage Collaborators

Subjects
Vaccine coverage, Vacunación de rutina, Time Factors, Vaccination Coverage, Global Plan of Action on Vaccines, Service delivery framework, IMPACT, Global Health, Cobertura de vacunas, Routine childhood vaccination, Global Burden of Disease, Public Health, Underserved Population, Polio vaccine, 0302 clinical medicine, WORLDWIDE, Routine immunisation, Global health, Medicine, 030212 general & internal medicine, Child, 11 Medical and Health Sciences, General Medicine, Articles, childhood vaccination, GBD, Plan de Acción Mundial sobre Vacunas, 3142 Public health care science, environmental and occupational health, 3. Good health, ddc, Vaccination, Poliovirus Vaccines, Action plan, Life Sciences & Biomedicine, Vacunación infantil, MED/42 - IGIENE GENERALE E APPLICATA, 030231 tropical medicine, Measles Vaccine, 03 medical and health sciences, Medicine, General & Internal, Environmental health, General & Internal Medicine, Humans, IMMUNIZATION COVERAGE, VALIDITY, Vaccination approaches, PROGRESS, Diphtheria-Tetanus-Pertussis Vaccine, CONFLICT, Equity (economics), Science & Technology, business.industry, MORTALITY, GBD 2020, Release 1, Vaccine Coverage Collaborators, Global burden of disease, injury and risk factors, Child vaccination, Global vaccine policies, Políticas mundiales de vacunación, Carga global de enfermedades, lesiones y factores de riesgo, Global vaccination policies, 3121 General medicine, internal medicine and other clinical medicine, Childhood vaccination, Measles vaccine, Routine vaccination, business, Vaccine programme implementation
Abstract

Medir la vacunación infantil de rutina es crucial para informar las políticas mundiales de vacunación y la implementación de programas, y para hacer un seguimiento del progreso hacia los objetivos establecidos por el Plan de Acción Mundial sobre Vacunas (GVAP) y la Agenda de Inmunización 2030. Se necesitan estimaciones sólidas de la cobertura de vacunación de rutina para identificar los éxitos pasados ​​y persistentes. vulnerabilidades. A partir del Estudio de la carga global de enfermedades, lesiones y factores de riesgo (GBD) 2020, versión 1, realizamos un análisis sistemático de las tendencias de cobertura de vacunas a nivel mundial, regional y nacional utilizando un marco estadístico, por vacuna y a lo largo del tiempo. Métodos Para este análisis recopilamos 55 326 observaciones específicas del país, de la cohorte, del año, de la vacuna y de la dosis de la cobertura de vacunación infantil de rutina entre 1980 y 2019. Utilizando el proceso de regresión gaussiana espaciotemporal, Estimaciones específicas por año de 11 indicadores de cobertura de vacunación infantil de rutina para 204 países y territorios desde 1980 hasta 2019, ajustando los sesgos en los datos informados por los países y reflejando los desabastecimientos informados y las interrupciones en el suministro. Analizamos las tendencias mundiales y regionales en la cobertura y el número de niños con dosis cero (definidos como aquellos que nunca recibieron una dosis de vacuna contra la difteria, el tétanos y la tos ferina [DTP]), el progreso hacia los objetivos del GVAP y la relación entre la cobertura de la vacuna y el desarrollo sociodemográfico. Recomendaciones Para 2019, la cobertura mundial de la tercera dosis de DTP (DTP3; 81,6 % [intervalo de incertidumbre del 95 % 80,4–82,7]) se duplicó con creces con respecto a los niveles estimados en 1980 (39,9 % [37,5–42 ·1]), al igual que la cobertura mundial de la vacuna antisarampionosa de primera dosis (MCV1; del 38,5 % [35,4–41,3] en 1980 al 83,6 % [82,3–84,8 ] en 2019). La cobertura de la vacuna antipoliomielítica de tercera dosis (Pol3) también aumentó, del 42,6 % (41,4–44,1) en 1980 al 79,8 % (78,4–81,1) en 2019, y la cobertura mundial de vacunas más nuevas Las vacunas aumentaron rápidamente entre 2000 y 2019. La cantidad mundial de niños que recibieron dosis cero se redujo en casi un 75 % entre 1980 y 2019, de 56,8 millones (52,6–60,9) a 14,5 millones (13,4– 15·9). Sin embargo, durante la última década, la cobertura mundial de vacunas se estabilizó en general; 94 países y territorios registraron una disminución de la cobertura de DTP3 desde 2010. Se estimó que solo 11 países y territorios alcanzaron el objetivo nacional del GVAP de al menos una cobertura del 90 % para todas las vacunas evaluadas en 2019. Interpretación Después de lograr grandes avances en la cobertura de vacunación infantil en todo el mundo, en gran parte del mundo este progreso se estancó o se revirtió de 2010 a 2019. Estos hallazgos subrayan la importancia de revisar las estrategias de inmunización de rutina y los enfoques programáticos, centrando la prestación de servicios en torno a la equidad y las poblaciones desatendidas. Fortalecer los datos de vacunas y los sistemas de monitoreo es crucial para estas actividades, ahora y hasta 2030, para garantizar que todos los niños tengan acceso y puedan beneficiarse de las vacunas que salvan vidas. Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization Agenda 2030. Robust estimates of routine vaccine coverage are needed to identify past successes and persistent vulnerabilities. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020, Release 1, we did a systematic analysis of global, regional, and national vaccine coverage trends using a statistical framework, by vaccine and over time. Methods For this analysis we collated 55 326 country-specific, cohort-specific, year-specific, vaccine-specific, and dose-specific observations of routine childhood vaccination coverage between 1980 and 2019. Using spatiotemporal Gaussian process regression, we produced location-specific and year-specific estimates of 11 routine childhood vaccine coverage indicators for 204 countries and territories from 1980 to 2019, adjusting for biases in country-reported data and reflecting reported stockouts and supply disruptions. We analysed global and regional trends in coverage and numbers of zero-dose children (defined as those who never received a diphtheria-tetanus-pertussis [DTP] vaccine dose), progress towards GVAP targets, and the relationship between vaccine coverage and sociodemographic development. Findings By 2019, global coverage of third-dose DTP (DTP3; 81·6% [95% uncertainty interval 80·4–82·7]) more than doubled from levels estimated in 1980 (39·9% [37·5–42·1]), as did global coverage of the first-dose measles-containing vaccine (MCV1; from 38·5% [35·4–41·3] in 1980 to 83·6% [82·3–84·8] in 2019). Third-dose polio vaccine (Pol3) coverage also increased, from 42·6% (41·4–44·1) in 1980 to 79·8% (78·4–81·1) in 2019, and global coverage of newer vaccines increased rapidly between 2000 and 2019. The global number of zero-dose children fell by nearly 75% between 1980 and 2019, from 56·8 million (52·6–60·9) to 14·5 million (13·4–15·9). However, over the past decade, global vaccine coverage broadly plateaued; 94 countries and territories recorded decreasing DTP3 coverage since 2010. Only 11 countries and territories were estimated to have reached the national GVAP target of at least 90% coverage for all assessed vaccines in 2019. Interpretation After achieving large gains in childhood vaccine coverage worldwide, in much of the world this progress was stalled or reversed from 2010 to 2019. These findings underscore the importance of revisiting routine immunisation strategies and programmatic approaches, recentring service delivery around equity and underserved populations. Strengthening vaccine data and monitoring systems is crucial to these pursuits, now and through to 2030, to ensure that all children have access to, and can benefit from, lifesaving vaccines.

Published
2021

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