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This study aims to trace the possible fate of the family of the High Priest of Ptah after the Roman conquest in 30bce. The mysterious death of Imhotep / Padibastetivcreated a clear rupture in the succession line. At first, Roman authorities seemed to hesitate to appoint a new high priest of Memphis, for various reasons, and thus waited almost three years to install Pasherienamunii, the first cousin of Imhotep / Padibastetiv, at the temple of Ptah. This occurred simultaneously with the creation of new priestly office: “prophet of the son of Caesar.” However, the embalmed body of Imhotep / Padibastetivremained unburied until 23bce, which might indicate previous dysfunctional mutual relations between the primary and the secondary branches of the same family.

During the autopsy of forensic cases, when there is no suspicion of drug use or chemical exposure, biological fluids may not be obtained for toxicological analysis, while specimens of tissues may be collected and preserved in a formalin solution for histological examination. When specific questions arise after the burial, the only possible options are the exhumation of an embalmed body or the toxicological analysis of the formalin-fixed specimens. The drug concentrations in these specimens can be altered due to the extraction efficiency and/or the chemical activity of the formalin solutions used during chemical fixation or embalming process. The aim of this paper is to review the published studies about the determination of specific groups of drugs in formalin-fixed or embalmed specimens and their stability after chemical fixation or embalming process. The analytical aspects of this determination are also discussed. The stability of drugs in formalin environment and the possible reaction of the drugs with formaldehyde, which is a highly reactive chemical substance, should always be considered during post-mortem/post-embalming forensic analysis. The additional analysis of the formalin solution in which the tissue was preserved is considered necessary. The identification and the evaluation of the possible degradation products or chemical derivatives are extremely useful during the interpretation of the results.

Occasionally, the only postmortem samples available for analysis are contaminated with formaldehyde, either due to embalming prior to sampling or because analysis is carried out only when formalin-fixed tissues retained for histological study are available. Formaldehyde reacts with several drugs of forensic interest that contain either a primary or a secondary amine group to form their N-methyl derivatives. We investigated the stability of 3,4-methylenedioxymethampetamine (MDMA), 4-methylmethcathinone (mephedrone) and 3-trifluromethylphenylpiperazine (3-TFMPP) in formalin solutions using three different formaldehyde concentrations (5, 10 and 20%) and three different pHs (3.0, 7.0 and 9.5). Analysis was performed using high-performance liquid chromatography with diode array detection to determine the percentage degradation of each drug over time, up to 60 days. MDMA, mephedrone and 3-TFMPP are unstable in formalin solutions, with the degradation rate increasing with increasing pH. After 28 days in 20% formalin, pH 9.5, there remained 57% of the initial 3-TFMPP concentration, 11% of the initial MDMA concentration and 4% of the initial mephedrone concentration. Forensic toxicologists should be aware that, when analyzing for these drugs in an embalmed body or in tissues stored in formalin solutions, the methylated form of the secondary amine-containing drug could be a more useful analyte than the parent drug.

The skeletons of 2 famous acromegalic giants: Charles Byrne (1761-1783) and Henri Cot = Joseph Dusorc (1883-1912) and the embalmed body of the famous acromegalic giant A parts per thousand douard Beaupr, (1881-1904) all ended up in the medical collections of museums despite the fact that these patients had never donated or even refused to donate their corpses, nor had their relatives given permission. The corpse of the acromegalic giant John Aasen (1890-1938) was voluntarily donated to a physician annex collector of trivia from acromegalic giants. The autopsy on the acromegalic giant John Turner (1874-1911) was performed during his funeral ceremony without the relatives being informed. Only recently, the acromegalic giant Alexander Sizonenko (1959-2012) was made a financial offer during his life in exchange for his body after his death. The case-histories of these 6 patients and also the circumstances that led to the (in-) voluntary donation of their bodies are reviewed.

METHODS This study investigates whether human cadavers embalmed according to Thiel can be used for research and education in oral-maxillo-facial surgery. Different surgical approaches were tested on such cadavers. The usability of the specimen was judged jointly by anatomists and surgeons. Color, structure, and consistency of the different tissues were comparable to vital conditions. Thiel's embalming technique applied to human cadavers provides an optimal basis for research and for basic and postgraduate medical education.

Publisher Summary This chapter focuses on the various forensic considerations that need to be taken into account while performing blood alcohol evaluation. Blood drawn from a decomposing body may yield a flawed alcohol concentration since decomposition involves fermentation, and blood sugar will allow fermentation to occur. Blood alcohol level, in fresh water drowning, may be reduced by dilution, since inhaled water enters the blood circulation. By the same token, transfusions and administration of intravenous fluids in hospitals also dilute blood alcohol concentrations. Therefore, it is advisable that in hospital cases, admission blood specimens drawn prior to fluid administration should be obtained from the emergency room and analyzed. Embalming fluids may contain methanol and/or other alcohols, however, ethanol is not a standard component. Therefore, any ethanol present in an embalmed body suggests that it was ingested prior to death. Blood, which is shed on the floor, the road, inside a vehicle, or anywhere outside the body. may be contaminated, and should not be used for alcohol testing.

(1968). Death Due to Parathion? Exhumation of an Embalmed Body. Clinical Toxicology: Vol. 1, No. 3, pp. 257-263.

Digoxin levels in post-mortem specimens are reported for two unusual cases. The blood level of digoxin in one of these cases was five times greater than any previously reported. The other case involved specimens from an embalmed body.