1. What is the restorative effect of VEGF inhibitor bevacuzimab against subarachnoid hemorrhage in an experimental model?
- Author
-
Deniz Billur, Ersin Özeren, Sevim Aydin, Adnan Demirci, Hakan Seçkin, Çetin Akyol, Kazim YİĞİtkanli, Pinar Bayram, Yahya Guvenc, Tıp Fakültesi, Demirci, Adnan Yalcin, Guvenc, Yahya, Ozeren, Ersin, Akyol, Cetin, Bayram, Pinar, Billur, Deniz, Aydin, Sevim, Seckin, Hakan, and Yigitkanli, Kazim
- Subjects
Male ,Vascular Endothelial Growth Factor A ,medicine.medical_specialty ,Subarachnoid hemorrhage ,INTRACRANIAL HEMORRHAGE ,CEREBRAL VASOSPASM ,Apoptosis ,Angiogenesis Inhibitors ,Cisterna magna ,ANGIOGENESIS ,PREDICT ,Magnetic resonance angiography ,RABBIT ,Internal medicine ,medicine.artery ,medicine ,Basilar artery ,Animals ,Vasospasm, Intracranial ,cardiovascular diseases ,medicine.diagnostic_test ,Vascular Endothelial Growth Factors ,business.industry ,Vasospasm ,General Medicine ,Subarachnoid Hemorrhage ,medicine.disease ,nervous system diseases ,Bevacizumab ,Disease Models, Animal ,Vasoconstriction ,Basilar Artery ,ENDOTHELIAL GROWTH-FACTOR ,cardiovascular system ,Cardiology ,Arterial blood ,Rabbits ,medicine.symptom ,business ,Perfusion - Abstract
BACKGROUND/AIM This study investigated the effect of vascular endothelial growth factor (VEGF) inhibitor bevacuzimab (BVZ) on the rabbit basilar artery using an experimental subarachnoid hemorrhage (SAH) model. MATERIALS AND METHODS Eighteen adult male New-Zealand white rabbits were randomly divided into three groups: a control group (n=6), SAH group (n=6), and SAH+BVZ group (n=6). Experimental SAH was created by injecting autologous arterial blood into the cisterna magna. In the treatment group, the subjects were administered a daily dose of 10 mg/kg, intravenous BVZ 2 days after the SAH. Basilar artery diameters were measured with magnetic resonance angiography (MRA) 72 hours after the SAH in all groups. After 72 hours the animals? whole brains, including the upper cervical region, were obtained from all the animals after perfusion and fixation of the animal. The wall thickness, luminal area, and the apoptosis at the basilar arteries were evaluated in all groups. RESULTS BVZ significantly prevented SAH induced vasospasm confirmed in-vivo with MRA imaging with additional suppression of apoptosis on basilar artery wall. CONCLUSION VEGF inhibition with BVZ has shown to have a vasospasm and apoptosis attenuating effect on basilar artery in a SAH model.
- Published
- 2021