1. NO-Generating Compounds Modify Tumoritoxic Effect of Doxorubicin
- Author
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G. V. Zagrebelnaya, E. Ts. Choinzonov, and I. V. Kondakova
- Subjects
Nitroprusside ,Arginine ,Apoptosis ,Nitric Oxide ,General Biochemistry, Genetics and Molecular Biology ,Nitric oxide ,Mice ,chemistry.chemical_compound ,medicine ,Animals ,Cytotoxic T cell ,Nitric Oxide Donors ,Doxorubicin ,Carcinoma, Ehrlich Tumor ,Antibiotics, Antineoplastic ,Sodium Nitrite ,DNA synthesis ,Chemistry ,DNA ,General Medicine ,In vitro ,Mice, Inbred C57BL ,Cancer research ,medicine.drug - Abstract
The effects of NO-generating compounds on the tumoritoxic effect of doxorubicin was evaluated by changes in DNA synthesis and apoptotic death of Ehrlich adenocarcinoma cells in vitro. NO donors significantly inhibited the cytotoxic effect of doxorubicin, which manifested in activation of DNA synthesis and decreased induction of apoptosis. Presumably, NO acts a factor protecting tumor cell DNA from the damaging effect of doxorubicin.
- Published
- 2004
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