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205 results on '"Dupeyron, A."'

1. Motivation toward physical activity in patients with chronic musculoskeletal disorders: a meta-analysis of the efficacy of behavioural interventions

Author

Matthieu Haas, Julie Boiché, Guillaume Chevance, Christophe Latrille, Mathis Brusseau, Anne-Lise Courbis, and Arnaud Dupeyron

Subjects
Medicine, Science
Abstract

Abstract Musculoskeletal disorders (MDs) represent a global health issue, which can lead to disability. Physical activity (PA) reduces pain and increases physical function among patients with MDs. To promote behavioural changes, it seems important to focus on modifiable factors, such as motivation. Thus, this review aims to assess effects of interventions targeting PA on motivation towards PA. Searches used terms referring to “physical activity”, “motivation” and “chronic musculoskeletal disorders” on the databases PubMed, PsychINFO, MEDLINE, EMBASE, PEDro and Web of Science. All types of intervention—including but not limited to RCTs—were eligible for inclusion. Risk of bias was assessed with the Quality Assessment Tool for Studies with Diverse Designs (QATSDD). Among 6 489 abstracts identified, there were 387 eligible studies and 19 were included, reporting in total 34 effect sizes. The meta-analysis concerned 1 869 patients and indicated a small effect of interventions on change in motivation towards PA (d = 0.34; 95% CI [0.15; 0.54]; p

Published
2024
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2. Smartphone applications are used for self-management, telerehabilitation, evaluation and data collection in low back pain healthcare: a scoping review [version 2; peer review: 2 approved]

Author

Emmanuel Coudeyre, Anne Plan-Paquet, Arnaud Dupeyron, Jean-Baptiste Lechauve, Didier Mbony-Irankunda, and Lech Dobija

Subjects
Smartphone apps, low back pain, mHealth, self-management, telerehabilitation, eng, Medicine, Science
Abstract

Background Smartphone use has grown in providing healthcare for patients with low back pain (LBP), but the literature lacks an analysis of the use of smartphone apps. This scoping review aimed to identify current areas of smartphone apps use for managing LBP. We also aimed to evaluate the current status of the effectiveness or scientific validity of such use and determine perspectives for their potential development. Methods We searched PubMed, PEDro and Embase for articles published in English up to May 3rd, 2021 that investigated smartphone use for LBP healthcare and their purpose. All types of study design were accepted. Studies concerning telemedicine or telerehabilitation but without use of a smartphone were not included. The same search strategy was performed by two researchers independently and a third researcher validated the synthesis of the included studies. Results We included 43 articles: randomised controlled trials (RCTs) (n=12), study protocols (n=6), reliability/validity studies (n=6), systematic reviews (n=7), cohort studies (n=4), qualitative studies (n=6), and case series (n=1). The purposes of the smartphone app were for 1) evaluation, 2) telerehabilitation, 3) self-management, and 4) data collection. Self-management was the most-studied use, showing promising results derived from moderate- to good-quality RCTs for patients with chronic LBP and patients after spinal surgery. Promising results exist regarding evaluation and data collection use and contradictory results regarding measurement use. Conclusions This scoping review revealed a notable interest in the scientific literatures regarding the use of smartphone apps for LBP patients. The identified purposes point to current scientific status and perspectives for further studies including RCTs and systematic reviews targeting specific usage.

Published
2024
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3. P428: De novo truncating variants in ZNF865: A putative cause of a neurodevelopmental disorder

Author

Sam Bradbrook, Gail Graham, Melissa Carter, Maria Kibaek, Martin Larsen, Christina Fagerberg, Katherine Dawson, Cheryl Meuter, Alexander Pepler, Thomas Besnard, Bertrand Isidor, Stéphane Bezieau, Benjamin Cogné, Marie Vincent, Katherine Bjorgo, Thomas Courtin, Lisa Emrick, Jill Rosenfeld, Undiagnosed Diseases Network, Julian Martinez-Agosto, Mathilde Heulin, Gilles Morin, Pauline Monin, Louis Januel, Marie-Noëlle Bonnet-Dupeyron, Mathilde Pujalte, Kim Worley, Monika Weisz-Hubshman, Patricia Dickson, Michelle Thompson, and Julien Marcadier

Subjects
Genetics, QH426-470, Medicine
Published
2024
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5. Fractal properties in sensorimotor variability unveil internal adaptations of the organism before symptomatic functional decline

Author

Kjerstin Torre, Grégoire Vergotte, Éric Viel, Stéphane Perrey, and Arnaud Dupeyron

Subjects
Medicine, Science
Abstract

Abstract If health can be defined as adaptability, then measures of adaptability are crucial. Convergent findings across clinical areas established the notion that fractal properties in bio-behavioural variability characterize the healthy condition of the organism, and its adaptive capacities in general. However, ambiguities remain as to the significance of fractal properties: the literature mainly discriminated between healthy vs. pathological states, thereby loosing perspective on the progression in between, and overlooking the distinction between adaptability and effective adaptations of the organism. Here, we design an experimental tapping paradigm involving gradual feedback deprivation in groups of healthy subjects and one deafferented man as a pathological-limit case. We show that distinct types of fractal properties in sensorimotor behaviour characterize, on the one hand impaired functional ability, and on the other hand internal adaptations for maintaining performance despite the imposed constraints. Findings may prove promising for early detection of internal adaptations preceding symptomatic functional decline.

Published
2019
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6. Contribution of Single-Fiber Evaluation on Monitoring Outcomes Following Injection of Botulinum Toxin-A: A Narrative Review of the Literature

Author

Hélène Moron, Corine Gagnard-Landra, David Guiraud, and Arnaud Dupeyron

Subjects
botulinum toxin, single-fiber, jitter, neuromuscular junction, electromyography, Medicine
Abstract

Botulinum toxin-A (BoNT-A) blocks acetylcholine release at the neuromuscular junction (NMJ) and is widely used for neuromuscular disorders (involuntary spasms, dystonic disorders and spasticity). However, its therapeutic effects are usually measured by clinical scales of questionable validity. Single-fiber electromyography (SFEMG) is a sensitive, validated diagnostic technique for NMJ impairment such as myasthenia. The jitter parameter (µs) represents the variability of interpotential intervals of two muscle fibers from the same motor unit. This narrative review reports SFEMG use in BoNT-A treatment. Twenty-four articles were selected from 175 eligible articles searched in Medline/Pubmed and Cochrane Library from their creation until May 2020. The results showed that jitter is sensitive to early NMJ modifications following BoNT-A injection, with an increase in the early days’ post-injection and a peak between Day 15 and 30, when symptoms diminish or disappear. The reappearance of symptoms accompanies a tendency for a decrease in jitter, but always precedes its normalization, either delayed or nonexistent. Increased jitter is observed in distant muscles from the injection site. No dose effect relationship was demonstrated. SFEMG could help physicians in their therapeutic evaluation according to the pathology considered. More data are needed to consider jitter as a predictor of BoNT-A clinical efficacy.

Published
2021
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7. The Back Belief Questionnaire is efficient to assess false beliefs and related fear in low back pain populations: A transcultural adaptation and validation study.

Author

Arnaud Dupeyron, Charlotte Lanhers, Sophie Bastide, Sandrine Alonso, Matthias Toulotte, Claire Jourdan, and Emmanuel Coudeyre

Subjects
Medicine, Science
Abstract

According to the fear avoidance model, beliefs and thoughts can modify the outcome of patient with low back pain. The Back Belief Questionnaire (BBQ)-a 14 items scale-assesses these consequences of low back pain.To test the psychometric properties of the French version of the BBQ.The BBQ was translated using the forward-backward translation process. Throughout three repeated evaluation time points (D1, D7 and D30), various aspects of validity were analysed: acceptability, quality of items, unidimentionality, internal consistency, temporal stability (between D1 and D7), responsiveness (between D7 and D30), and construct validity comparing it to other validated scales.One hundred and thirty-one patients were enrolled and 128 were analyzed. The acceptability and the quality of the items were excellent. The scale was unidimensional and reliable (internal consistency: Cronbach's α = 0.8). The responsiveness was moderate but in line with other scores. The BBQ was, as expected, convergent with day-to-day activities and fear avoidance (FABQ and Tampa), disability (Quebec and Dallas scores), or anxiety and depression (HAD); and not correlated with pain. Best correlations were found with Tampa and FABQ. The temporal stability (test-retest reliability) was poor. However, similar changes were observed in near conceptual score (FABQ), which confirmed that clinical status may have not been stable and suggesting sensitivity to early changes for BBQ.The BBQ showed good psychometric properties to assess false beliefs and related fear in French or English LBP populations and can be used either for evaluation in international trials or as a part of self-care training.

Published
2017
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8. Facilitators and barriers to physical activity in people with chronic low back pain: A qualitative study.

Author

Laura Boutevillain, Arnaud Dupeyron, Caroline Rouch, Emilie Richard, and Emmanuel Coudeyre

Subjects
Medicine, Science
Abstract

For medical teams, one of the main objectives of rehabilitation for people with chronic low back pain is adherence to physical activity (PA).The objective of this study was to identify PA barriers and facilitators in this population.This qualitative study included 4 discussion groups and 16 semi-structured interviews conducted among people with non-specific chronic low back pain who were involved in a specific rehabilitation program or seen in primary care settings.Three main themes were identified: physical factors, psychological factors and socio-environmental factors. The main barrier to PA practice is pain. Psychological barriers were associated with the difficulty in integrating PA in the person's daily life. Environmental barriers were dominated by lack of time. Facilitators identified associated the supervised nature of the physical activity (supervision by professionals) and group practice, which improved people's adherence.The results of this study will allow teams to target relevant educational objectives for these people and develop dedicated self-management programs.

Published
2017
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9. Relationship between gait complexity and pain attention in chronic low back pain

Author

Kjerstin Torre, Arnaud Dupeyron, and Alexis F Homs

Subjects
medicine.medical_specialty, business.industry, Repeated measures design, STRIDE, Motor control, Walking, Gait, humanities, Biomechanical Phenomena, Walking Speed, Preferred walking speed, Anesthesiology and Pain Medicine, Physical medicine and rehabilitation, Neurology, Distraction, Post-hoc analysis, medicine, Humans, Neurology (clinical), Chronic Pain, Treadmill, business, Low Back Pain, human activities
Abstract

Clinical models of chronic low back pain (cLBP) highlight the role of excessive attention to pain and kinesiophobia on the origin of disability. At the motor control level, various mechanisms are involved in the impairments observed in patients with cLBP. We aimed to assess the role of maladaptative attentional behaviors by using a complex systems approach and a visual display as a distraction during walking. Sixteen patients with cLBP with no previous surgery or significant leg pain and 16 healthy matched controls were included. Patients walked on a treadmill at preferred walking speed with and without distraction. Stride time (ST) fractal complexity was assessed using detrended fluctuation analysis. A two-way analysis of variance with repeated measures on distraction was performed on fractal exponents. We found a significant group × distraction interaction effect on fractal complexity of ST series (F(1,30) = 9.972, P = 0.004). Post hoc analysis showed that, without distraction, patients with cLBP had significantly lower ST complexity than controls, but when distracted, they regained gait complexity, recovering the level of controls. Our results suggest that excessive attention to pain causes loss of complexity and adaptability in cLBP and explain alterations of motor control with pain. Fractal analysis seems to be a promising method to explore movement variability and individual adaptability in musculoskeletal disorders.

Published
2021

10. Between-day reliability of IMU-derived spine control metrics in patients with low back pain

Author

Ryan B. Graham, Arnaud Dupeyron, Jaap H. van Dieën, School of Human Kinetics, University of Ottawa, EuroMov - Digital Health in Motion (Euromov DHM), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Vrije Universiteit Amsterdam [Amsterdam] (VU), Neuromechanics, AMS - Ageing & Vitality, and AMS - Musculoskeletal Health

Subjects
medicine.medical_specialty, Coefficient of variation, Movement, 0206 medical engineering, Biomedical Engineering, Biophysics, 02 engineering and technology, Standard deviation, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Neuromuscular control, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Medicine, Humans, Orthopedics and Sports Medicine, Variability, Pelvis, Reliability (statistics), business.industry, Rehabilitation, Biomechanics, Reproducibility of Results, Torso, 020601 biomedical engineering, Low back pain, Trunk, Sagittal plane, Local divergence exponents, Spine, Biomechanical Phenomena, Benchmarking, medicine.anatomical_structure, Wearable sensors, medicine.symptom, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], business, Low Back Pain, 030217 neurology & neurosurgery
Abstract

Inertial measurement units (IMUs) are a potentially useful tool for clinicians and researchers in assessing spine movement biomechanics and neuromuscular control patterns. This study assessed the between-day reliability of the HIKOB FOX IMU in measuring local dynamic stability (LDS) and variability of trunk movements in patients with chronic low back pain (LBP). The local divergence exponent (λmax) was used to quantify LDS and the mean standard deviation (MeanSD) between cycles was used to quantify variability during 30 repetitive cycles of flexion/extension, rotation, and complex movement tasks. For λmax the average coefficient of variation (CV) was ~10% in the flexion/extension and rotation tasks, and all CV values were max ranged from 0.28 to 0.81. Reliability of λmax was similar between the pelvis and thorax segments (CV: ~10%, ICC: 0.48–0.78) and worse for the lumbar spine (CV: ~15%, ICC: 0.28–0.59). The CV for MeanSD was typically in the range of 20–30%, with even greater CV in the non-primary axes during each task (30–52%). Similarly, ICC values were lowest about the anterior-posterior axis in the flexion/extension task (ICC: 0.15–0.29) and largest about the longitudinal axis in the rotation task (ICC: 0.76–0.88). The moderate between-day reliability of λmax in the sagittal and transverse planes offers improvement over manual and subjective tests with poor reliability that are currently used in clinics. The minimal detectable differences presented give a threshold for change in research and rehabilitation in patients with LBP.

Published
2020

11. Criteria for inclusion in programs of functional restoration for chronic low back pain: Pragmatic Study

Author

Marina Assadourian, Laure Gossec, Bruno Fautrel, Johann Beaudreuil, B. Duplan, Sophia Ascione, Pierre Letellier, Laetitia Morardet, Arnaud Dupeyron, Florian Bailly, Nada Ibrahim-Nasser, Isabelle Griffoul, Antoine Potel, Myrianne Le Ralle, Violaine Foltz, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de rhumatologie [CHU Pitié Salpêtrière] (GRC-08 EEMOIS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Métropole Savoie [Chambéry], Service de Rhumatologie [CHU Lariboisière], Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Euromov (EuroMov), Université de Montpellier (UM), Centre Hospitalier Régional d'Orléans (CHRO), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de Rhumatologie [CHU Pitié Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Herrada, Anthony

Subjects
Male, 030506 rehabilitation, Chronic pain, Anxiety, Hospital Anxiety and Depression Scale, 0302 clinical medicine, Medicine, Orthopedics and Sports Medicine, Practice Patterns, Physicians', 10. No inequality, Referral and Consultation, Pain Measurement, Public health, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Depression, Rehabilitation, Middle Aged, Combined Modality Therapy, 3. Good health, Oswestry Disability Index, Sick leave, Chronic low back pain, Female, France, Sick Leave, medicine.symptom, 0305 other medical science, Adult, medicine.medical_specialty, Referral, 03 medical and health sciences, Humans, Exercise, Physical activity, business.industry, Patient Selection, Odds ratio, medicine.disease, Cross-Sectional Studies, Logistic Models, Multivariate Analysis, Physical therapy, Observational study, Self Report, business, Low Back Pain, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract

International audience; Background: Individuals with chronic low back pain (cLBP) may benefit from multimodal functional restoration programs (FRPs).Objective: The aim of this study was to analyze characteristics of individuals with cLBP who were referred or not to an FRP. Because cLBP is a bio-psycho-social disorder, medical and social parameters were analysed.Methods: This was an observational cross-sectional study performed in 2017 in 6 tertiary centres in France. Consecutive individuals with cLBP visiting a rheumatologist or physical medicine and rehabilitation physician were included. Individuals referred or not to an FRP were compared by demographic characteristics, duration of sick leave over the past year, self-reported physical activity>1h/week, pain (numeric rating scale 0-10), anxiety/depression (Hospital Anxiety and Depression Scale), disability (Oswestry Disability Index) and kinesiophobia (Tampa Kinesiophobia Scale). Univariate and multivariate logistic regression analyses were performed, estimating odds ratios (ORs) and 95% confidence intervals (CIs).Results: We included 147 individuals with cLBP. The mean (SD) age was 49 (12) years and 88 (60%) were women; 58 (38%) were referred to an FRP. On multivariate analysis, referral to an FRP was associated with reduced pain level (OR: 0.95, 95% CI: 0.91-0.99, for each 1-point increase in pain score), self-reported lack of physical activity (OR: 0.84, 95% CI: 0.72-0.98) and longer sick leave (OR: 1.03, 95% CI: 1.01-1.05, for 30 more days of sick leave).Conclusion: In this multicentric observational study, referral to an FRP was linked to pain, self-reported physical activity and sick leave but not medical characteristics assessed. These findings confirm the bio-psycho-social approach of FRPs for cLBP.

Published
2020

12. Classification of 101 BRCA1 and BRCA2 variants of uncertain significance by cosegregation study: A powerful approach

Author

Marie-Noëlle Bonnet-Dupeyron, Helene Dreyfus, Nadia Boutry-Kryza, Cornel Popovici, Laurent Castera, Nancy Uhrhammer, Anthony Laugé, Yves-Jean Bignon, Hélène Delhomelle, Alice Fiévet, Christophe Guy, Noémie Bronnec, Bruno Buecher, Fabienne Prieur, Sophie Demontety, Vincent Goussot, Emmanuelle Mouret-Fourme, Claire Saule, Helene Zattara, Sarah Malsa, Paul Gesta, Cindy Meira, Erell Guillerm, Isabelle Turbiez, Agathe Ricou, Mélanie Léoné, Pierre Vande Perre, Sarab Lizard, Pascaline Berthet, Norbert Lignon, Adrien Buisson, Anne-Marie Birot, Philippe Denizeau, Etienne Rouleau, Odile Cohen-Haguenauer, Veronica Goldbarg, Virginie Moncoutier, Charlotte Benigni, Emmanuelle Barouk-Simonet, Flavie Boulouard, Caroline Jacquot-Sawka, Alice Yvard, Hakima Lallaoui, Veronica Cusin, Angélina Legros, Muriel Belotti, Christine Maugard, Marine Guillaud-Bataille, Jean-Marc Limacher, Marion Gauthier-Villars, Louise Crivelli, Afane Brahimi, Odile Cabaret, Ophelie Bertrand, Michel Longy, Gabrielle Le Guyadec, Doriane Livon, Amelie Bloucard, Dominique Stoppa-Lyonnet, Capucine Delnatte, Caroline Lecerf, Jennifer Carriere, Virginie Guibert, Véronique Mari, Anne-Sophie Allary, Florence Coulet, Françoise Bonnet, Paul Vilquin, Noémie Basset, Khadija Abidallah, Pierre Macquere, Nicolas Derive, Manon Boulaire, Stephanie Chieze-Valéro, Marine Le Mentec, Mathilde Gay-Bellile, Anne-Laure Conoy, Henri Margot, Pierre Devulder, Mathias Schwartz, Isabelle Tennevet, Stéphane Bézieau, Francesca Damiola, Violaine Bourdon, Audrey Mailliez, Zoe Nevière, Nicolas Viellard, Laurence Venat, Antoine De Pauw, Brigitte Bressac-de Paillerets, Agnès Hardouin, Sofiane Lacoste, Sandra Fert-Ferrer, Maud Privat, Helene Larbre, Dominique Vaur, Etienne Muller, Françoise Revillion, Clémentine Legrand, Rosette Lidereau, Laurence Gladieff, Sabine Raad, Jean Chiesa, Diane Molière, Ahmed Bouras, Nicolas Sevenet, Patrick R. Benusiglio, Sophie Giraud, Christine Toulas, Voreak Suybeng, Florine Oca, Tetsuro Noguchi, Catherine Dehainault, Sophie Lejeune, Céline Heude, Catherine Dubois d’Enghein, Thien-vu Nguyen Minh Tuan, Olivier Caron, Mathilde Warcoin, Christine Lasset, Claude Houdayer, Jessica Moretta-Serra, Julie Tinat, Hagay Sobol, Natalie Jones, Fanny Brayotel, Anne Fajac, Virginie Bubien, Maud Blanluet, Jean-Marc Rey, Anne Durlach, Sandrine M. Caputo, Isabelle Coupier, Fatoumata Simaga, Sophie Krieger, Catherine Noguès, Fabrice Airaud, Robin Fouillet, Celine Garrec, Valérie Bonadona, Julie Menjard, Bérengère Legendre, Chrystelle Colas, Christelle Berthemin, Camille Cohen, Caroline Abadie, Olivier Ingster, Audrey Remenieras, Anaïs Dupré, Jessica Le Gall, Lisa Golmard, Marie Bidart, Henrique Tenreiro, J Bombled, Marie-Charlotte Villy, Marie-Agnès Collonge-Rame, Sophie Dussart, Alain Lortholary, Lucie Salle, Samira Fekairi, Service de Génétique Oncologique, Institut Curie [Paris], Université Paris sciences et lettres (PSL), Département de Biologie des Tumeurs, Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL), Centre Léon Bérard [Lyon], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Gustave Roussy (IGR), Génétique (Biologie pathologie), Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut de biochimie et génétique cellulaires (IBGC), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre de Références Cancers Rares (PREDIR), INCA, Institut national du cancer [Boulogne] (INCA), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), Centre Hospitalier Universitaire de Reims (CHU Reims), dormoy, valerian, Unité fonctionnelle de neurogénétique moléculaire et cellulaire, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Service de Génétique Cytogénétique et Embryologie [CHU Pitié-Salpêtrière]

Subjects
Cosegregation, Genotype, [SDV]Life Sciences [q-bio], Breast Neoplasms, Biology, Article, 03 medical and health sciences, Likely benign, Genetics, medicine, Humans, Clinical significance, Genetic Predisposition to Disease, Genetic Testing, Uncertain significance, Gene, ComputingMilieux_MISCELLANEOUS, Genetics (clinical), 030304 developmental biology, BRCA2 Protein, Ovarian Neoplasms, 0303 health sciences, Cancer predisposition, BRCA1 Protein, 030305 genetics & heredity, Cancer, Genetic Variation, medicine.disease, 3. Good health, [SDV] Life Sciences [q-bio], Classification methods, Female
Abstract

Up to 80% of BRCA1 and BRCA2 genetic variants remain of uncertain clinical significance (VUSs). Only variants classified as pathogenic or likely pathogenic can guide breast and ovarian cancer prevention measures and treatment by PARP inhibitors. We report the first results of the ongoing French national COVAR (cosegregation variant) study, the aim of which is to classify BRCA1/2 VUSs. The classification method was a multifactorial model combining different associations between VUSs and cancer, including cosegregation data. At this time, among the 653 variants selected, 101 (15%) distinct variants shared by 1,624 families were classified as pathogenic/likely pathogenic or benign/likely benign by the COVAR study. Sixty-six of the 101 (65%) variants classified by COVAR would have remained VUSs without cosegregation data. Of note, among the 34 variants classified as pathogenic by COVAR, 16 remained VUSs or likely pathogenic when following the ACMG/AMP variant classification guidelines. Although the initiation and organization of cosegregation analyses require a considerable effort, the growing number of available genetic tests results in an increasing number of families sharing a particular variant, and thereby increases the power of such analyses. Here we demonstrate that variant cosegregation analyses are a powerful tool for the classification of variants in the BRCA1/2 breast-ovarian cancer predisposition genes.

Published
2021

13. Functional traits of carabid beetles reveal seasonal variation in community assembly in annual crops

Author

Ronan Marrec, Dupeyron A, Bertrand Gauffre, Isabelle Badenhausser, Bretagnolle, Gaël Caro, Marilyn Roncoroni, Nicolas Gross, Ecologie et Dynamique des Systèmes Anthropisés - UMR CNRS 7058 (EDYSAN), Centre National de la Recherche Scientifique (CNRS)-Université de Picardie Jules Verne (UPJV), Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, Growing season, spatiotemporal dynamics, Biology, arthropods, 010603 evolutionary biology, 01 natural sciences, Crop, seasonal dynamics, Resource Acquisition Is Initialization, medicine, functional traits, agriculture, business.industry, Ecology, 010604 marine biology & hydrobiology, carabid beetles, Niche differentiation, 15. Life on land, Seasonality, crop phenology, medicine.disease, Habitat, Agriculture, [SDE]Environmental Sciences, Biological dispersal, business, body size
Abstract

Trait-based community assembly studies have mostly been addressed along spatial gradients, and do not consider explicitly a fundamental dimension governing community assembly, the time. Nevertheless, such consideration seems particularly necessary in systems in which organisms have to face regular disturbances and rapid changes in vegetation phenology, such as in intensively managed farmlands.In this study, we aimed at understanding how the functional diversity of carabid beetle communities varied across the growing season in response to crop type. We tested three alternative hypotheses on mechanisms underlying the community assembly.We used data from a long-term monitoring conducted over nine years in an intensively-managed farmland in central western France, in a total of 625 fields. First, we measured morphological traits related to body size, dispersal mode, and resource acquisition on the 13 dominant carabid species (> 85 % of all trapped individuals) and identified three independent dimensions of functional specialization within our species pool along axes of a PCA and highlighted key traits for community assembly. Second, we evaluated the community assembly temporal dynamics and the impact of habitat filtering and niche differentiation in the different crop types with time, using linear mixed-effects models.We showed that functional species assembly of carabid beetle communities occurring in crop fields varies importantly intra-annually, with strong variations in these dynamics depending on crop type and crop phenology. Each crop acted as a filter on carabid communities for body size and resource-acquisition traits, and functional differentiation between crops increased with time. We did not find any evidence of habitat filtering on traits related to dispersal mode.Our results emphasize the major role of crop phenology but also disturbances involved by agricultural practices such as crop harvesting on changes in community assembly, likely due to seasonal and inter-annual redistributions of species in agricultural landscapes in response to such changes. The temporal dimension cannot be ignored to understand the assembly of local carabid communities in farmlands.

Published
2021

14. Fractal properties in sensorimotor variability unveil internal adaptations of the organism before symptomatic functional decline

Author

Éric Viel, Arnaud Dupeyron, Stéphane Perrey, Kjerstin Torre, Grégoire Vergotte, Euromov (EuroMov), Université de Montpellier (UM), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), and Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)

Subjects
Adult, Male, Causalgia, Time series, Acclimatization, media_common.quotation_subject, Science, Early detection, Article, 050105 experimental psychology, Adaptability, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Fractal, Motor control, Humans, 0501 psychology and cognitive sciences, Functional ability, Functional decline, Organism, media_common, Multidisciplinary, 05 social sciences, Perspective (graphical), Healthy subjects, Middle Aged, Adaptation, Physiological, Fractals, Acoustic Stimulation, Medicine, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Sensorimotor Cortex, Psychology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery, Cognitive psychology
Abstract

If health can be defined as adaptability, then measures of adaptability are crucial. Convergent findings across clinical areas established the notion that fractal properties in bio-behavioural variability characterize the healthy condition of the organism, and its adaptive capacities in general. However, ambiguities remain as to the significance of fractal properties: the literature mainly discriminated between healthy vs. pathological states, thereby loosing perspective on the progression in between, and overlooking the distinction between adaptability and effective adaptations of the organism. Here, we design an experimental tapping paradigm involving gradual feedback deprivation in groups of healthy subjects and one deafferented man as a pathological-limit case. We show that distinct types of fractal properties in sensorimotor behaviour characterize, on the one hand impaired functional ability, and on the other hand internal adaptations for maintaining performance despite the imposed constraints. Findings may prove promising for early detection of internal adaptations preceding symptomatic functional decline.

Published
2019

15. Alpha-phase synchrony EEG training for multi-resistant chronic low back pain patients: an open-label pilot study

Author

Marco Congedo, Arnaud Dupeyron, M. Ritz, Hélène Wu, Quentin Barthélemy, Patrick Favennec, Y. Delpierre, Louis Mayaud, Mensia Technologies [Paris], Covea Tech [Paris], Centre de l'Arche [PRH Le Mans], GIPSA - Vision and Brain Signal Processing (GIPSA-VIBS), Département Images et Signal (GIPSA-DIS), Grenoble Images Parole Signal Automatique (GIPSA-lab ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Grenoble Images Parole Signal Automatique (GIPSA-lab ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Département de Rééducation et Réadaptation Neuro Orthopédique [Nîmes] (Pôle NACRRE), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), and Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)

Subjects
Adult, medicine.medical_specialty, Adolescent, Visual Analog Scale, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Visual analogue scale, medicine.medical_treatment, Population, Pilot Projects, Context (language use), Electroencephalography, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, medicine, Humans, Orthopedics and Sports Medicine, education, ComputingMilieux_MISCELLANEOUS, 030222 orthopedics, education.field_of_study, Rehabilitation, Resting state fMRI, medicine.diagnostic_test, business.industry, Middle Aged, Neurofeedback, 3. Good health, Opioid, Conditioning, Operant, Female, Surgery, Chronic Pain, business, Low Back Pain, 030217 neurology & neurosurgery, medicine.drug
Abstract

Chronic low back pain (cLBP) affects a quarter of a population during its lifetime. The most severe cases include patients not responding to interventions such as 5-week-long in-hospital multi-disciplinary protocols. This document reports on a pilot study offering an alpha-phase synchronization (APS) brain rehabilitation intervention to a population of n = 16 multi-resistant cLBP patients. The intervention consists of 20 sessions of highly controlled electroencephalography (EEG) APS operant conditioning (neurofeedback) paradigm delivered in the form of visual feedback. Visual analogue scale for pain, Dallas, Hamilton, and HAD were measured before, after, at 6-month and 12-month follow-up. Full-scalp EEG data were analyzed to study significant changes in the brain’s electrical activity. The intervention showed a great and lasting response of most measured clinical scales. The clinical improvement was lasting beyond the 6-month follow-up endpoints. The EEG data confirm that patients did control (intra-session trends) and learned to better control (intersession trends) their APS neuromarker resulting in (nonsignificant) baseline changes in their resting state activity. Last and most significantly, the alpha-phase concentration (APC) neuromarker, specific to phase rather than amplitude, was found to correlate significantly with the reduction in clinical symptoms in a typical dose–response effect. This first experiment highlights the role of the APC neuromarker in relation to the nucleus accumbens activity and its role on nociception and the chronicity of pain. This study suggests APC rehabilitation could be used clinically for the most severe cases of cLBP. Its excellent safety profile and availability as a home-use intervention makes it a potentially disruptive tool in the context of nonsteroidal anti-inflammatory drugs and opioid abuses. These slides can be retrieved under Electronic Supplementary Material.

Published
2019

16. Risk factors of pelvic pressure ulcer recurrence after primary skin flap surgery in people with spinal cord injury

Author

C. Mauri, Nicolas Frasson, A. Gelis, C. Herlin, Arnaud Dupeyron, B. Amara, C. Verollet, H. Rouays, Jacques Morel, J.-P. Daures, C. Jourdan, Isabelle Almeras, Service de Médecine Physique et Réadaptation [CHU de Grenoble] (MPR), Centre Hospitalier Universitaire [Grenoble] (CHU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Hôpital Lapeyronie [Montpellier] (CHU), Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Euromov (EuroMov), Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), and Institut Universitaire de Recherche Clinique

Subjects
Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Multivariate analysis, medicine.medical_treatment, Spinal cord injury, Surgical Flaps, Pelvis, Young Adult, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Recurrence, Risk Factors, medicine, Humans, Orthopedics and Sports Medicine, Risk factor, Spinal Cord Injuries, Aged, Proportional Hazards Models, Retrospective Studies, Aged, 80 and over, Pressure Ulcer, business.industry, Flap surgery, Rehabilitation, Hazard ratio, Colostomy, Retrospective cohort study, Skin Transplantation, Middle Aged, medicine.disease, Confidence interval, 3. Good health, Surgery, Treatment Outcome, Regression Analysis, Female, Observational study, 0305 other medical science, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract

Background Flap surgery for deep pelvic pressure ulcers (PPUs) has been found effective, but the recurrence rate remains high and few risk factors have been identified. Objective We evaluated risk factors for PU recurrence after primary flap surgery in people with spinal cord injury (SCI). Patients and methods This observational retrospective study based on medical charts included all individuals with SCI who underwent primary flap surgery for a PPU in the Herault department in France between 2006 and 2014. Overall, 100 biomedical, psychological, socioeconomic and care management factors were studied. The primary outcome was PPU recurrence (surgical site and/or other pelvic site). The secondary outcome was recurrence at the surgical site. Cox proportional hazards regression was used to determine associated factors, estimating hazard ratios (HRs) and 95% confidence intervals (CIs). Results We included 85 patients. Half had a PPU recurrence, and in one-third, the recurrence was at the surgical site. On multivariate analysis, global PPU recurrence was associated with colostomy (HR = 2.79) and living with a partner (HR = 2.29). Non-traumatic SCI and sacral wound were associated with PPU recurrence (HR = 3.39, HR = 0.48) and recurrence at the surgical site (HR = 3.3, HR = 0.3). Conclusion Risk factors of PPU recurrence are based on both biomedical and social models. After primary flap surgery, the risk of recurrence justifies regular follow-up and strict monitoring.

Published
2019

17. French legal approach to clinical research

Author

Anna Harbonn, Elisabeth Toulouse, Christophe Masseguin, Sophie Granier, Jason A. Roberts, Gordon McGurk, Jean Etienne Bazin, Arnaud Dupeyron, Brigitte Lafont, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Université de Montpellier (UM), and Queensland Institute of Medical Research

Subjects
Biomedical Research, media_common.quotation_subject, education, Legislation, Critical Care and Intensive Care Medicine, Clinical research, Retrospective data, 03 medical and health sciences, 0302 clinical medicine, State (polity), 030202 anesthesiology, Humans, Medicine, Data Protection Act 1998, European Union, health care economics and organizations, media_common, Ethics, Informed Consent, business.industry, 030208 emergency & critical care medicine, General Medicine, 16. Peace & justice, Institutional review board, humanities, 3. Good health, Europe, Intervention (law), Anesthesiology and Pain Medicine, Order (business), Law, France, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Since 1988, France has been committed to drafting laws regulating clinical research. These laws must both reflect general legal standards relating to personal data protection and patient information and comply with EU regulations, which are supra-national norms. The 2012 legislation known as "Jardé law" came into force in 2016 and distinguishes between 3 different types of research involving human subjects: category 1:interventional research implying an intervention on the patient which is not justified by their usual treatment. Category 2: interventional research, which does not focus on medicinal products and only entails minimal risks and constraints. Category 3: non-interventional research implying one or multiple acts or proceedings devoid of listed risks. These studies require preliminary favourable opinions from the French Ethical Research Committees (CPP), who are appointed by the State, and must ensure the protection of personal data. For the other types of studies (retrospective data, practice surveys), French legislation only requires that the protection of personal data is ensured. However, it is highly recommended to submit these studies to an Institutional Review Board (IRB) in order to confirm that human subjects are not involved and to obtain an ethical opinion in the event of a scientific journal submission. These laws are constantly evolving in order to comply with the various international recommendations and European regulations, which are binding in France.

Published
2018

18. Contribution of Single-Fiber Evaluation on Monitoring Outcomes Following Injection of Botulinum Toxin-A: A Narrative Review of the Literature

Author

Corine Gagnard-Landra, Hélène Moron, David Guiraud, Arnaud Dupeyron, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), EuroMov - Digital Health in Motion (Euromov DHM), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Montpellier (UM), Contrôle Artificiel de Mouvements et de Neuroprothèses Intuitives (CAMIN), Inria Sophia Antipolis - Méditerranée (CRISAM), and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)

Subjects
030506 rehabilitation, medicine.medical_specialty, single-fiber, electromyography, jitter, Health, Toxicology and Mutagenesis, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Muscle Fibers, Skeletal, Acetylcholine Release Inhibitors, Electromyography, Review, Cochrane Library, Toxicology, Neuromuscular junction, [SPI.AUTO]Engineering Sciences [physics]/Automatic, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], otorhinolaryngologic diseases, Humans, Spasticity, botulinum toxin, Botulinum Toxins, Type A, Jitter, medicine.diagnostic_test, neuromuscular junction, business.industry, Neuromuscular Diseases, Botulinum toxin, 3. Good health, Motor unit, medicine.anatomical_structure, Neuromuscular Agents, Medicine, medicine.symptom, 0305 other medical science, business, 030217 neurology & neurosurgery, Dystonic disorder, medicine.drug
Abstract

International audience; Botulinum toxin-A (BoNT-A) blocks acetylcholine release at the neuromuscular junction (NMJ) and is widely used for neuromuscular disorders (involuntary spasms, dystonic disorders and spasticity). However, its therapeutic effects are usually measured by clinical scales of questionable validity. Single-fiber electromyography (SFEMG) is a sensitive, validated diagnostic technique for NMJ impairment such as myasthenia. The jitter parameter (µs) represents the variability of interpotential intervals of two muscle fibers from the same motor unit. This narrative review reports SFEMG use in BoNT-A treatment. Twenty-four articles were selected from 175 eligible articles searched in Medline/Pubmed and Cochrane Library from their creation until May 2020. The results showed that jitter is sensitive to early NMJ modifications following BoNT-A injection, with an increase in the early days’ post-injection and a peak between Day 15 and 30, when symptoms diminish or disappear. The reappearance of symptoms accompanies a tendency for a decrease in jitter, but always precedes its normalization, either delayed or nonexistent. Increased jitter is observed in distant muscles from the injection site. No dose effect relationship was demonstrated. SFEMG could help physicians in their therapeutic evaluation according to the pathology considered. More data are needed to consider jitter as a predictor of BoNT-A clinical efficacy.

Published
2021

19. Subungual squamous cell carcinoma in a BAP1 germline pathogenic variant carrier

Author

Marie-Noelle Bonnet-Dupeyron, Brigitte Balme, Luc Thomas, Brigitte Bressac-de Paillerets, Lisa Golmard, and Safa Idoudi

Subjects
Uveal Neoplasms, BAP1, business.industry, Tumor Suppressor Proteins, Dermatology, medicine.disease, Germline, Nail Diseases, Infectious Diseases, Germ Cells, Nail disease, Cancer research, Carcinoma, Squamous Cell, Medicine, Humans, Basal cell, Genetic Predisposition to Disease, business, Ubiquitin Thiolesterase, Germ-Line Mutation
Published
2021

20. Comparison of interface pressures in two dynamic pressure ulcer prevention supports (NIMBUS 3 and SUMMIT): A randomized controlled trial

Author

Willy Fagart, E. Viollet, Arnaud Dupeyron, Mylène Blot, Sophie Bastide, Sandrine Alonso, Anthony Gelis, Fabrice Nouvel, and Claire de Labachelerie

Subjects
medicine.medical_specialty, Sacrum, Randomization, Supine position, Deep vein, Dermatology, Beds, Pathology and Forensic Medicine, law.invention, Older patients, Randomized controlled trial, law, Interface pressure, Medicine, Humans, Aged, Pressure Ulcer, geography, Summit, geography.geographical_feature_category, business.industry, Skin Care, medicine.anatomical_structure, Physical therapy, Dynamic pressure, France, business
Abstract

Pressure ulcers are a risk for bedridden patients and various supports exist to prevent them. The Pressure Relief Index (PRI) evaluates pressure relief of dynamic mattresses over time. This study compared the PRI of the SUMMIT mattress (AKS-France) and the NIMBUS 3 (HNE Medical).In this non-blinded, randomized, crossover, non-inferiority study, patients aged ≥60 with a BMI of 16-35 kg/m2, predominantly confined to bed, able to walk with aid and with pelvic symmetry were recruited from a hospital rehabilitation department from March-April 2012. Exclusion criteria included past or present pressure ulcers, inability to remain supine and deep vein thrombosis. Peak pressures of the sacrum were recorded at 0.1 Hz during a single complete 10-min inflating cycle on both mattresses, with the order determined via electronic randomization allocation.Thirty-one subjects were included and randomized; with 14 finally analyzed in the SUMMIT-NIBMUS 3 order group and 16 in the NIMBUS 3-SUMMIT group. The difference in PRI30 mmHg between the two mattresses was 13.2% [0.3-26.1] (p 0.05), allowing a non-inferiority - superiority switch. The SUMMIT mattress demonstrated a significantly higher percentage of time30 mmHg (p = 0.0454). No significant difference in mean minimal pressure was seen (p = 0.3231) and mean maximal pressure was in favor of SUMMIT mattress (p = 0.0096). BMI did not affect pressure profile. There were no adverse events.Evaluated by the PRI, the SUMMIT mattress had a better interface pressure profile than the NIMBUS 3 in older patients. The PRI is a promising tool for clinical decision-making and research, warranting validation.

Published
2021

21. mHealth App for Pressure Ulcer Wound Assessment in Patients With Spinal Cord Injury: Clinical Validation Study

Author

Stéphane Verdun, Ariane Do Khac, Isabelle Laffont, Arnaud Dupeyron, Claire Jourdan, Sylvain Fazilleau, Anthony Gelis, and Claire Palayer

Subjects
Validation study, medicine.medical_specialty, validity, Intraclass correlation, wound, assessment, availability, Health Informatics, 030207 dermatology & venereal diseases, 03 medical and health sciences, Wound assessment, 0302 clinical medicine, access, mobile app, Medicine, Humans, In patient, 030212 general & internal medicine, mHealth, Spinal cord injury, app, reproducibility, Spinal Cord Injuries, Pressure Ulcer, Reproducibility, Original Paper, reliability, business.industry, Reproducibility of Results, medicine.disease, Standard technique, Mobile Applications, Telemedicine, correlation, Physical therapy, business
Abstract

Background Clinical evaluation of a pressure ulcer is based on quantitative and qualitative evaluation. In clinical practice, acetate tracing is the standard technique used to measure wound surface area; however, it is difficult to use in daily practice (because of material availability, data storage issues, and time needed to calculate the surface area). Planimetry techniques developed with mobile health (mHealth) apps can be used to overcome these difficulties. Objective The goal of this study was to evaluate the metrological properties of a free-access mHealth app, called imitoMeasure, to assess pressure ulcers. Methods This was a noninterventional, validation study. We included patients with spinal cord injury presenting with a pressure ulcer, regardless of its stage or location. We performed wound measurements with a ruler, and we performed acetate tracing using a transparent dressing with a wound measurement grid. Wound evaluation via the mHealth app was conducted twice by the main investigator and also by a coinvestigator to determine validity, intrarater reproducibility, and interrater reproducibility. Bland-Altman plots and intraclass correlation coefficients were used to compute the minimal detectable change percentage. Results Overall, 61 different pressure ulcers were included. The validity, intrarater reproducibility, and interrater reproducibility of the mHealth app vs acetate tracing (considered the method of reference) were good, with intraclass correlation coefficients of 0.97 (95% CI 0.93-0.99), 0.99 (95% CI 0.98-0.99), and 0.98 (95% CI 0.96-0.99), respectively, and minimal detectable change percentages between 17% and 35%. Conclusions The imitoMeasure app had good validity and reproducibility. It could be an alternative to standard wound assessment methods. Further studies on larger and more diverse wounds are needed. Trial Registration ClinicalTrials.gov NCT04402398; http://clinicaltrials.gov/ct2/show/NCT04402398

Published
2020

22. Rehabilitation of the upper arm early after stroke: Video games versus conventional rehabilitation. A randomized controlled trial

Author

Arnaud Dupeyron, Jérôme Froger, Huei Yune Bonnin, Isabelle Laffont, Denis Mottet, Liesjet van Dokkum, Philippe Armingaud, Abdelkader Gouaich, Emmanuelle Le Bars, Anthony Gelis, Marie Christine Picot, Audrey Jaussent, Caroline Arquizan, C. Jourdan, K. Bakhti, Euromov (EuroMov), Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Système Multi-agent, Interaction, Langage, Evolution (SMILE), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut d’Imagerie Fonctionnelle Humaine [CHU Montpellier] (I2FH), Laboratoire Charles Coulomb (L2C), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Département de Médecine Physique et de Réadaptation [Montpellier], Hôpital Lapeyronie [Montpellier] (CHU), Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Dynamique des capacités humaines et des conduites de santé (EPSYLON), Université de Montpellier (UM)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université Montpellier 1 (UM1), and Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Montpellier (UM)

Subjects
Occupational therapy, Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Randomization, medicine.medical_treatment, law.invention, [SHS]Humanities and Social Sciences, Video games, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Quality of life, Randomized controlled trial, Occupational Therapy, law, medicine, Humans, Orthopedics and Sports Medicine, Single-Blind Method, [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC], Upper limb, Stroke, Aged, Aged, 80 and over, Rehabilitation, Hand Strength, business.industry, Stroke Rehabilitation, Recovery of Function, Middle Aged, University hospital, medicine.disease, 3. Good health, medicine.anatomical_structure, Treatment Outcome, Physical therapy, Arm, Female, 0305 other medical science, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Background Few rehabilitation methods have proven their efficacy in increasing sensori-motor recovery and/or function of the upper limb (UL) after stroke. Video games (VGs) are promising tools in this indication. Objective To compare UL rehabilitation by using VGs and conventional rehabilitation (CR) in patients with sub-acute stroke. Design Single-blind, multicentric trial, with central randomization and stratification by center. Setting Physical and rehabilitation medicine departments of 2 university hospitals. Participants Adults within 3 months after a first vascular cerebral accident, with UL Fugl Meyer Score (UL-FMS) Intervention A 45-min additional session of conventional occupational therapy (OT) or a VG-based OT session as add-on therapy to usual rehabilitation programs, 5 days/week for 6 weeks. Main Outcome Measures Primary outcome: UL-FMS. Secondary outcome: Box and Block Test (BBT), Wolf Motor Function test (WMFT), Motor Activity Log (MAL), Barthel Index and quality of life (SF-36). Results We included 51 patients (20 women) at a mean (SD) of 27.2 (19.4) days post-stroke (mean age 58 years [range 24–83]), 26 in the CR group and 25 in the VG group (23 in each group at 6-month follow-up). The mean duration of the additional rehabilitation session was similar in both groups: 29.3 (4.3) vs 28.0 (4.4) min in CR and VG groups. Shoulder pain occurred in 4 patients in the VG group versus 7 in the CR group. At day 45, gain in UL-FMS did not significantly differ between the groups (CR mean 17.8 [14.6] vs VG 24.1 [14.8]; P = 0.10), whereas gain in BBT was doubled in the VG group (CR 7.4 [12.2] vs VG 15.7 [16.3]; P = 0.02). At 6-month follow-up, the study was inconclusive about between-group differences in UL-FMS, BBT and other criteria. Post-hoc analysis showed that gains in UL-FMS or BBT were significantly higher in the VG than CR group for patients included within 30 days post-stroke. Conclusion In general, we cannot conclude that video gaming and conventional OT led to different long-term sensorimotor recovery of the UL after sub-acute stroke. However, when applied within the first month after stroke, video gaming was more efficient than conventional rehabilitation on both sensorimotor recovery and gross grasping function. Trial registration ClinicalTrials.gov ( NCT01554449 ).

Published
2020

23. 'Doctor, how long will it take?' Results from an historical cohort on surgical pressure ulcer healing delay and related factors in persons with spinal cord injury

Author

Isabelle Almeras, Nicolas Frasson, Jean-Pierre Daurès, Isabelle Laffont, Hélène Rouays, Christian Herlin, C. Verollet, Arnaud Dupeyron, C. Mauri, Anthony Gelis, Juliette Morel, and Bouali Amara

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Dermatology, Pathology and Forensic Medicine, Sepsis, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Acute care, Medicine, Humans, Risk factor, Spinal cord injury, Spinal Cord Injuries, Retrospective Studies, Pressure Ulcer, Wound Healing, Rehabilitation, 030504 nursing, business.industry, Retrospective cohort study, Middle Aged, medicine.disease, Surgery, Female, France, 0305 other medical science, Complication, business, Wound healing
Abstract

Background Flap surgery for deep pelvic pressure ulcers has already shown its effectiveness. Most studies relating to the postoperative period assessed complications rates and associated risk factors, but none focused on delayed wound healing. The objective of this study was to describe wound healing delay after primary flap surgery in patients with spinal cord injury (SCI) and to assess associated risk factors. Methods This observational retrospective study based on medical charts included all persons with SCI operated for primary flap surgery for pelvic PU in the Herault department of France between 2006 and 2014. Overall, 100 biomedical, psychological, socioeconomics and care management factors were studied. The primary outcome was wound healing delay, defined as time from surgery to complete cutaneous closure. Results 85 patients were included. Median healing time was 48 days (R: 20–406). Healing rate was 70% at 3 months and 90% at 4 months. After a multivariate analysis three factors were significantly associated with delayed wound healing: duration of hospitalization in the acute care unit (HR = 2.68; p = 0.004), local post-operative complication (HR = 10.75; p = 0.02), and post-operative sepsis (HR = 2.18; p = 0.02). Conclusion After primary skin flap surgery for PU in persons with SCI, delayed wound healing is related to local or general complications as well as care management organization. The risk of delayed wound healing justifies the implementation of a coordinated pre-operative management to prevent complications and a structured care network for an earlier transfer to a SCI rehabilitation center.

Published
2020

24. Validity and internal consistency of the French version of the revised Skin Management Needs Assessment Checklist in people with spinal cord injury

Author

Gélis, Anthony, Dupeyron, Arnaud, Daures, Jean Pierre, Goossens, David, Gault, Dominique, Pedelucq, Jean Paul, Enjalbert, Michel, Maupas, Eric, Kennedy, Paul, Fattal, Charles, Group, French SMNAC, Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Université de Montpellier (UM), Euromov (EuroMov), Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques (LGMR), IFR3, Université Montpellier 1 (UM1)-Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Centre de Rééducation Fonctionnelle Divio [Dijon] (CRF COS Divio)

Subjects
Adult, Male, Health Knowledge, Attitudes, Practice, 030506 rehabilitation, medicine.medical_specialty, Psychometrics, Cross-sectional study, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Hospital Anxiety and Depression Scale, Skin Diseases, Young Adult, 03 medical and health sciences, 0302 clinical medicine, 80 and over, medicine, Humans, Spinal cord injury, Spinal Cord Injuries, Aged, Rank correlation, Aged, 80 and over, Practice, Rehabilitation, business.industry, Health Knowledge, Self-Management, Reproducibility of Results, Construct validity, General Medicine, Middle Aged, medicine.disease, Checklist, 3. Good health, Cross-Sectional Studies, Neurology, Attitudes, Physical therapy, Female, Neurology (clinical), 0305 other medical science, business, Needs Assessment, 030217 neurology & neurosurgery
Abstract

International audience; STUDY DESIGN: Cross-sectional psychometrics study. OBJECTIVES: To determine the construct validity and internal consistency of the revised Skin Management Needs Assessment Checklist (revised SMnac). SETTING: Six spinal cord rehabilitation centers. METHODS: One-hundred and thirty-two community-dwelling individuals with spinal cord injury (SCI) were included. Construct validity was assessed by a Spearman's rank correlation coefficient between the revised SMnac and several questionnaires: Rosenberg Self-Esteem Scale, Ways of Coping Questionnaire, Hospital Anxiety and Depression Scale (HADS), Braden scale; or clinical variables: educational level, presence of a pressure ulcer (PU), history of multiple PUs, time since injury, and pain. RESULTS: The study evidenced construct validity with a fair to moderate correlation coefficient between the revised SMnac and Rosenberg scale (rs = 0.25; p = 0.03), active coping (rs = 0.29; p = 0.001), HADS (rs = -0.43; p \textless 0.0001), and time since injury (rs = 0.49; p \textless 0.0001). The presence of PU and history of multiple PUs were strongly correlated with the revised SMnac score (respectively, p = 0.01 and 0.001). Internal consistency was excellent (α = 0.907). CONCLUSION: These results show that the revised SMnac is a valid tool to assess PU self-management in individuals with SCI. Further studies are needed to assess the revised SMnac's responsiveness to change.

Published
2018

25. Six-Month Safety and Efficacy of the Intelligent Retinal Implant System II Device in Retinitis Pigmentosa

Author

Gérard Dupeyron, Borja Corcóstegui, Didier Audemard, Yannick Le Mer, Michaela Velikay-Parel, Michel Weber, Mahiul M. K. Muqit, and Jose A. Sahel

Subjects
medicine.medical_specialty, Time Factors, Treatment outcome, Retinal implant, Visual Acuity, MEDLINE, Electric Stimulation Therapy, Ophthalmology, Retinitis pigmentosa, Humans, Medicine, Prospective Studies, Prospective cohort study, business.industry, Middle Aged, medicine.disease, Electrodes, Implanted, Visual Prosthesis, Clinical trial, Treatment Outcome, Multicenter study, Visual prosthesis, Visual Field Tests, Visual Fields, business, Retinitis Pigmentosa
Published
2019

27. Pelvic parameters and sagittal alignment in people with chronic low back pain and active discopathy (Modic 1 changes): A case–control study

Author

Francis Abed Rabbo, Guillaume Coll, Nicolas Coste, Laurent Sakka, Pascal Kouyoumdjian, Arnaud Dupeyron, Service de Neurochirurgie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Université Clermont Auvergne (UCA), Département de Rééducation et Réadaptation Neuro Orthopédique [Nîmes] (Pôle NACRRE), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Service de Chirurgie Orthopédique et Traumatologique [CHU Clermont-Ferrand], Unité de Nutrition Humaine (UNH), and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA)

Subjects
MESH: Pelvis, medicine.medical_specialty, Lumbar Vertebrae, MESH: Humans, business.industry, MESH: Low Back Pain, Rehabilitation, Case-control study, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, MESH: Case-Control Studies, Pelvis, Chronic low back pain, MESH: Lumbar Vertebrae, Physical medicine and rehabilitation, Case-Control Studies, Humans, Sagittal alignment, Medicine, Orthopedics and Sports Medicine, business, Low Back Pain, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Letter; International audience; Dear Editor. We read with interest the letter ‘‘Pelvic parameters and sagittal alignment in people with chronic low back pain and active discopathy (Modic 1 changes): a case–control study’’ by Blandin et al. [1] and would like to propose some comments.

Published
2021

28. Rehabilitation and lumbar surgery: the French recommendations for clinical practice

Author

Julien Nizard, Xavier Dufour, P. Ribinik, Pascal Kouyoumdjian, François Rannou, Sarah Kabani, Emmanuel Coudeyre, Clement Silvestre, Joel Godard, Arnaud Dupeyron, Jean Huppert, Violaine Foltz, Audrey Petit, and Christophe Demoulin

Subjects
Medical education, Rehabilitation, business.industry, medicine.medical_treatment, Psychological intervention, Context (language use), Session (web analytics), Multidisciplinary approach, medicine, Orthopedics and Sports Medicine, Medical prescription, Grading (education), business, Patient education
Abstract

Background Indications and techniques of rehabilitation differ widely across types of lumbar surgery, including timing (before or after surgery) and prescriptions (surgeons but also medical or paramedical professionals). Objectives This project aimed to build consensual recommendations for practice in this context. Methods The SOFMER methodology was used to establish recommendations for physical medicine and rehabilitation: a steering committee defined the types of lumbar surgery involved and developed the main questions to be addressed; a scientific committee performed a literature review for grading evidence and proposed the first version of recommendations, which were discussed during a dedicated session at the national Physical and Rehabilitation Medicine congress; then an e-Delphi method with cross-professional experts was used to finalise recommendations and reach a multidisciplinary consensus. Results The main questions developed were the value of rehabilitation before and after surgery, timing and type of rehabilitation, benefit of supervision and instrumental rehabilitation, value of patient education, and complementary interventions concerning rehabilitation for discectomy, fusion, and disc prosthesis (excluding decompression for spinal stenosis). The literature review identified 60 articles, but for several of the questions, no article in the literature addressed the issue. The multidisciplinary scientific committee analysed the literature and addressed the questions to propose the first version of a set of 23 recommendations. The congress session failed to answer all questions or to reach consensus for all items. After a three-step e-Delphi, 20 recommendations were retained, for which consensus among experts was reached. The recommendations are applicable only to patients without a neurological lesion. Conclusions These recommendations provide important and consensual knowledge to assist clinicians in decision-making for rehabilitation in lumbar surgery. Despite many of the recommendations relying exclusively on expert opinion rather than published evidence, this approach is an important advance to improve concordance among healthcare professionals.

Published
2021

29. Connaissances et attentes des programmes de réentraînement à l’effort chez les patients lombalgiques chroniques : étude miroir chez 150 patients et 80 médecins en 2017

Author

Marina Assadourian, B. Duplan, Bruno Fautrel, Johann Beaudreuil, Sophia Ascione, Pierre Letellier, Laure Gossec, Arnaud Dupeyron, Florian Bailly, Nada Ibrahim-Nasser, Antoine Potel, Myrianne Le Ralle, Laetitia Morardet, Isabelle Griffoul-Espitalier, and Violaine Foltz

Subjects
Rheumatology, business.industry, Medicine, business
Published
2020

30. 'What pressure ulcers mean to me?' Representations of pressure ulcer in persons with spinal cord injury: A qualitative study

Author

David Goossens, Bernard Foulon, Arnaud Dupeyron, Anthony Gelis, Sarah Mathieu, Mathieu Gourlan, Isabelle Laffont, Dominique Gault, Sandrine Robineau, Marc Lefort, Alessandra Pellechia, Grégory Ninot, Dynamique des capacités humaines et des conduites de santé (EPSYLON), Université Paul-Valéry - Montpellier 3 (UPVM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Unité Transversale D'éducation Du Patient (UTEP (Montpellier)), Médecine Physique et de Réadaptation [Rennes] (Pôle Saint-Hélier), Association des Paralysés de France (APF (Montpellier)), Centre de Rééducation Clémenceau, Hôpital Saint-Jacques [Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Rééducation de La Tour de Gassies (CMPR), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de KERPAPE [Ploemeur] (CMRRF), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape, Département Médecine Physique et Réadaptation [Montpellier], Hôpital Lapeyronie [Montpellier] (CHU), Euromov (EuroMov), Université de Montpellier (UM), Département de Rééducation et Réadaptation Neuro Orthopédique [Nîmes] (Pôle NACRRE), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), and Languedoc Mutualité

Subjects
Male, MESH: Chi-Square Distribution, Psychological intervention, Surgical Flaps, Cohort Studies, 030207 dermatology & venereal diseases, 0302 clinical medicine, Risk Factors, MESH: Spinal Cord Injuries / complications, Surveys and Questionnaires, MESH: Qualitative Research, Spinal cord injury, MESH: Cohort Studies, Qualitative Research, Pressure Ulcer, education.field_of_study, Self-management, MESH: Middle Aged, 030504 nursing, Middle Aged, 3. Good health, MESH: Pressure Ulcer / etiology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, 0305 other medical science, Paraplegia, Psychosocial, MESH: Surgical Flaps / blood supply, Adult, medicine.medical_specialty, Referral, Population, Dermatology, Pathology and Forensic Medicine, 03 medical and health sciences, medicine, Humans, MESH: Surgical Flaps / surgery, education, Spinal Cord Injuries, MESH: Humans, Chi-Square Distribution, Inpatient care, business.industry, Prevention, medicine.disease, Physical therapy, Qualitative study, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Objectives Explore the perceptions and beliefs related to pressure ulcers (PU), their prevention and treatment strategies, in order to discuss potential learning objectives for PU-related therapeutic education in persons with spinal cord injury (SCI). Design Qualitative study, using grounded theory for the analysis of data collected via a questionnaire. Setting Nine SCI referral centers, inpatient care. Participants 131 persons with SCI were included. 76% were male, and 65% presented with paraplegia. The median age was 48 years (33.5; 58) and median time since injury was 11 years (3; 24.5). 70% had experience with PU. Interventions None. Main outcome measures Data collection via an open-ended questionnaire on the representation of PU, its prevention and life experience of having a PU. Results Six categories were identified: (1) identifying what might become problematic, (2) daily preventive actions, (3) detecting the early signs, (4) managing the early signs, (5) need for care, (6) experience with PU and being bedridden. Pressure ulcers have dramatic consequences on psychosocial health. Prevention and treatment require self-management skills, such as self-risk assessment abilities, self-detection skills and problem-solving strategies, to optimise daily PU prevention in persons with SCI. Conclusion PU prevention tackled by persons with SCI bears some specificities that the physician must take into account in the construction of a self-management program in this high-risk population.

Published
2019

31. Clinical and genetic characterization of individuals with predicted deleterious PHIP variants

Author

Ashley Wilson, Jane Juusola, Keri Ramsey, Antonio Vitobello, Wendy K. Chung, Marie-Noelle Bonnet Dupeyron, Kirsten E. Craddock, Volkan Okur, Jennifer Heeley, Laurence Faivre, and Erica H. Gerkes

Subjects
Genetics, 0303 health sciences, Mutation, IDENTIFICATION, business.industry, media_common.quotation_subject, Nonsense, General Medicine, medicine.disease, medicine.disease_cause, Hypotonia, Frameshift mutation, 03 medical and health sciences, 0302 clinical medicine, Intellectual disability, Missense mutation, Medicine, Attention deficit hyperactivity disorder, Autism, medicine.symptom, business, 030217 neurology & neurosurgery, 030304 developmental biology, media_common
Abstract

Heterozygous deleterious variants in PHIP have been associated with behavioral problems, intellectual disability/developmental delay, obesity/overweight, and dysmorphic features (BIDOD syndrome). We report an additional 10 individuals with pleckstrin homology domain-interacting protein (PHIP)-predicted deleterious variants (four frameshift, three missense, two nonsense, and one splice site; six of which are confirmed de novo). The mutation spectrum is diverse, and there is no clustering of mutations across the protein. The clinical phenotype of these individuals is consistent with previous reports and includes behavioral problems, intellectual disability, developmental delay, hypotonia, and dysmorphic features. The additional individuals we report have a lower frequency of obesity than previous reports and a higher frequency of gastrointestinal problems, social deficits, and behavioral challenges. Characterizing additional individuals with diverse mutations longitudinally will provide better natural history data to assist with medical management and educational and behavioral support.

Published
2019

32. Isokinetic thigh muscle strength testing in professional French Rugby Union players: A database as a reference in pre-season strength rehabilitation rather than the controlateral limb

Author

M. Julia, Bernard Dusfour, Jean-Claude Peyrin, Dominique Morand, Armand Bonnin, Arnaud Dupeyron, Bruno Pereira, Emmanuel Coudeyre, Jean-Louis Croisier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Médecine Physique et de Réadaptation [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Louise Michel [Clermont-Ferrand], CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Liège (CHU-Liège), Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Commission médicale Ligue Nationale de Rugby, and Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)

Subjects
MESH: Muscle, Skeletal, medicine.medical_specialty, MESH: Humans, Rehabilitation, business.industry, MESH: Muscle Strength, medicine.medical_treatment, Thigh muscle, MEDLINE, MESH: Rugby, Physical medicine and rehabilitation, Thigh, Medicine, Strength testing, Humans, Orthopedics and Sports Medicine, Muscle Strength, Rugby, Seasons, business, Muscle, Skeletal, MESH: Seasons, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, MESH: Thigh
Abstract

Letter; International audience; Isokinetic testing is currently considered the gold standard for measuring dynamic muscle thigh strength (hamstring and quadriceps) [1], [2]. Isokinetic thigh muscle testing can provide valuable information to design effective preventive strategies for athletes.

Published
2019

33. Knowledge of and expectations about functional restoration programs for chronic low back pain: A mirror survey of 150 patients and 80 physicians in 2017

Author

Bruno Fautrel, Johann Beaudreuil, Marina Assadourian, Arnaud Dupeyron, Pierre Letellier, Nada Ibrahim-Nasser, Florian Bailly, Violaine Foltz, Laure Gossec, Isabelle Griffoul-Espitalier, Laetitia Morardet, Antoine Potel, B. Duplan, Sophia Ascione, and Myrianne Le Ralle

Subjects
Adult, Male, medicine.medical_specialty, Health Knowledge, Attitudes, Practice, Severity of Illness Index, Tertiary Care Centers, Text mining, Rheumatology, Medicine, Humans, Program Development, Aged, Pain Measurement, Patient Care Team, Analgesics, business.industry, Middle Aged, Chronic low back pain, Exercise Therapy, Cross-Sectional Studies, Chronic Disease, Physical therapy, Female, France, business, Low Back Pain, Program Evaluation
Published
2019

34. Analgesic gas for rehabilitation of frozen shoulder: Protocol for a randomized controlled trial

Author

Dominique Richard, I. Tavares, Sylvie Petiot, Anthony Gelis, Arnaud Dupeyron, Emmanuel Coudeyre, Christel Castelli, Lech Dobija, Marie Dénarié, Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Université de Montpellier (UM), Euromov (EuroMov), Service de Médecine Physique et de Réadaptation, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Hôpital Corentin Celton [Issy-les-Moulineaux], Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Département de Biostatistique, Epidémiologie, Santé Publique et Informatique Médicale (BESPIM), Département Médecine Physique et Réadaptation, Centre Hospitalier Universitaire Lapeyronie (CHU Lapeyronie), Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, and Institut National de la Recherche Agronomique (INRA)

Subjects
Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Shoulder, Nitrogen, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Analgesic, Adhesive capsulitis, Placebo, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Quality of life, Double-Blind Method, law, Bursitis, Medicine, Humans, Orthopedics and Sports Medicine, Range of Motion, Articular, Physical Therapy Modalities, Pain Measurement, Randomized Controlled Trials as Topic, Analgesics, Rehabilitation, business.industry, Frozen shoulder, medicine.disease, 3. Good health, Oxygen, Regimen, Capsulitis, Treatment Outcome, Physical therapy, Quality of Life, Female, Analgesia, 0305 other medical science, business, 030217 neurology & neurosurgery
Abstract

Background There is little evidence regarding the best way to treat adhesive capsulitis. Physical therapy can reduce pain and improve function and range of motion. However, we lack clear indications on the regimen, techniques or intensity of physical therapy to achieve better results. Intensive physical therapy seems to be confined to the later stages of adhesive capsulitis (chronic stage) given that rehabilitation-induced pain could worsen the outcomes. Here we describe a protocol for a study comparing the efficacy of a standardized program of intensive mobilization under analgesic gas to a similar program under placebo gas and questioning the impact of pain. Method/Design A randomized, double-blind, multicenter study — the MEOPA Trial — was designed to include adults with strictly defined clinical adhesive capsulitis for a 14-day intensive physical rehabilitation program under an equimolar mixture of oxygen and nitrous oxide or sham gas administration. Efficacy will be assessed by the Constant-Murley score. Data for secondary criteria including pain, disability, quality of life and perceived efficacy by the patient or physiotherapist will be collected over 6 months. Discussion This randomized controlled trial has been designed to test the effectiveness of intensive physical therapy under a simple and safe analgesic method. This study will also address the effect of pain during rehabilitation in adhesive capsulitis. Furthermore, results from the 6-month multidimensional follow-up of painful mobilization for this condition could be extrapolated to other musculoskeletal conditions. Trial registration ClinicalTrials.gov No. NCT01087229 .

Published
2019

35. Intradiscal glucocorticoids injection in chronic low back pain with active discopathy: A randomized controlled study

Author

Ahmed Larbi, I. Tavares, Arnaud Dupeyron, Anthony Gelis, Catherine Cyteval, Eric Thomas, Yann Thouvenin, Federico Manna, P. Viala, Marie-Christine Picot, Valérie Macioce, and Isabelle Laffont

Subjects
Male, 030506 rehabilitation, Lidocaine, Visual analogue scale, Analgesic, law.invention, 03 medical and health sciences, 0302 clinical medicine, Lumbar, Randomized controlled trial, law, Humans, Medicine, Single-Blind Method, Orthopedics and Sports Medicine, Prospective Studies, Glucocorticoids, Injections, Spinal, business.industry, Rehabilitation, Middle Aged, Low back pain, Chronic low back pain, Oswestry Disability Index, Anesthesia, Female, medicine.symptom, 0305 other medical science, business, Low Back Pain, Intervertebral Disc Displacement, 030217 neurology & neurosurgery, medicine.drug
Abstract

The benefit of an intradiscal injection of corticosteroids for low back pain with active discopathy is not totally resolved.The objective of this study was to estimate the clinical efficacy of an intradiscal injection of glucocorticoids versus lidocaine in patients with low back pain and active discopathy (Modic 1 changes).A prospective, single-blind, randomized controlled study was conducted in 2 tertiary care centers with spine units. We enrolled 50 patients (mean age 50 years; 46% women) with lumbar active discopathy on MRI and failure of medical treatment for more than 6 weeks. Participants were randomly assigned to receive an intradiscal injection of glucocorticoids [50mg prednisolone acetate (GC group), n=24] or lidocaine [40mg (L group), n=26] by senior radiologists. Outcome measures were low back pain in the previous 8 days (10-point visual analog scale), Dallas Pain Questionnaire, Oswestry Disability Index, analgesic treatment and work status at 1, 3 and 6 months as well as pain at 1, 2 and 3 weeks. The primary outcome was change in pain between baseline and 1 month.Data for 39 patients (78%; 17 in the GC group, 22 in the L group) were analyzed for the primary outcome. Pain intensity was significantly reduced at 1 month in the GC versus L group [mean (SD) -2.7 (2.3) and +0.1 (2.0), P0.001] but not at 3 and 6 months. At 1 and 3 months, the groups significantly differed in daily activities of the Dallas Pain Questionnaire in favour of the GC group. The groups did not differ in consumption of analgesics or professional condition at any time. No serious intervention-related adverse events occurred. Study limitations included patients lost to the study because of injection-related technical issues in the L5/S1 disc and short time of follow-up.As compared with intradiscal injection of lidocaine, intradiscal injection of prednisolone acetate for low back pain with active discopathy may reduce pain intensity at 1 month but not at 3 and 6 months.

Published
2021

36. Home-based cycling using connected ergometric bicycles for people with lumbar spinal stenosis (FLEXCAL): Protocol for a randomised trial

Author

A. Roren, Emmanuel Coudeyre, Marie-Martine Lefèvre-Colau, Isabelle Boutron, Arnaud Dupeyron, Gabriel Baron, Christelle Nguyen, Serge Poiraudeau, François Rannou, Charlotte Pauwels, Université Paris Cité - UFR Médecine [Santé] (UPCité UFR Médecine), Université Paris Cité (UPCité), Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service de rééducation et de réadaptation de l'appareil locomoteur et des pathologies du rachis [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Hôtel-Dieu [Paris], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Service de Médecine Physique et de Réadaptation [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Louise Michel [Clermont-Ferrand], CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Salvy-Córdoba, Nathalie, and UFR Médecine [Santé] - Université Paris Cité (UFR Médecine UPCité)

Subjects
musculoskeletal diseases, medicine.medical_specialty, MEDLINE, MESH: Pain Measurement, MESH: Bicycling, MESH: Lumbar Vertebrae, medicine, MESH: Exercise Therapy, Orthopedics and Sports Medicine, MESH: Treatment Outcome, Protocol (science), MESH: Humans, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Rehabilitation, Lumbar spinal stenosis, MESH: Spinal Stenosis, medicine.disease, Home based, MESH: Randomized Controlled Trials as Topic, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Physical therapy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Cycling, business, human activities, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Letter; International audience; Dear editor, Lumbar spinal stenosis (LSS) is the narrowing of the lumbar canal caused by degenerative processes [1]. LSS results in back and lower-limb pain when standing and walking, and symptoms regress in sitting position [1]. These symptoms are named neurogenic claudication and result from mechanical irritation and from exercise-induced ischemia of the cauda equina [2]. The inability to stand or walk alters functioning and health-related quality of life (HRQoL)

Published
2021

37. Correction to: Alpha-phase synchrony EEG training for multi-resistant chronic low back pain patients: an open-label pilot stud

Author

Hélène Wu, Quentin Barthélemy, M. Ritz, Patrick Favennec, Y. Delpierre, Marco Congedo, Arnaud Dupeyron, and Louis Mayaud

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Alpha (ethology), Electroencephalography, Electronic Supplementary Material, Resistant tuberculosis, Chronic low back pain, Physical medicine and rehabilitation, medicine, Orthopedics and Sports Medicine, Surgery, Open label, business
Abstract

Unfortunately, the original version of this article has been published without the electronic supplementary material.

Published
2020

38. High-Force Versus Low-Force Lumbar Traction in Acute Lumbar Sciatica Due to Disc Herniation: A Preliminary Randomized Trial

Author

Erik Sauleau, Philippe Vautravers, Stéphane P. Dufour, Marie-Eve Isner-Horobeti, Michael Schaeffer, J. Lecocq, Arnaud Dupeyron, Institut Universitaire de Réadaptation Clemenceau (IURC), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Euromov (EuroMov), and Université de Montpellier (UM)

Subjects
musculoskeletal diseases, medicine.medical_specialty, Visual analogue scale, medicine.medical_treatment, law.invention, Sciatica, 03 medical and health sciences, 0302 clinical medicine, Lumbar, Double-Blind Method, Randomized controlled trial, Traction, law, medicine, Back pain, Humans, 030212 general & internal medicine, Neuropathic Pain, Lumbar Vertebrae, business.industry, Traction (orthopedics), medicine.disease, Surgery, Treatment Outcome, Back Pain, Radicular pain, Intervertebral Disc Displacement, Anesthesia, Chiropractics, medicine.symptom, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract

International audience; OBJECTIVE:This study compared the effects of high-force versus low-force lumbar traction in the treatment of acute lumbar sciatica secondary to disc herniation.METHODS:A randomized double blind trial was performed, and 17 subjects with acute lumbar sciatica secondary to disc herniation were assigned to high-force traction at 50% body weight (BW; LT50, n = 8) or low force traction at 10% BW (LT10, n = 9) for 10 sessions in 2 weeks. Radicular pain (visual analogue scale [VAS]), lumbo-pelvic-hip complex motion (finger-to-toe test), lumbar-spine mobility (Schöber-Macrae test), nerve root compression (straight-leg-raising test), disability (EIFEL score), drug consumption, and overall evaluation of each patient were measured at days 0, 7, 1, 4, and 28.RESULTS:Significant (P < .05) improvements were observed in the LT50 and LT10 groups, respectively, between day 0 and day 14 (end of treatment) for VAS (-44% and -36%), EIFEL score (-43% and -28%) and overall patient evaluation (+3.1 and +2.0 points). At that time, LT50 specifically improved in the finger-to-toe test (-42%), the straight-leg-raising test (+58), and drug consumption (-50%). No significant interaction effect (group-by-time) was revealed, and the effect of traction treatment was independent of the level of medication. During the 2-week follow-up at day 28, only the LT10 group improved (P < .05) in VAS (-52%) and EIFEL scores (-46%). During this period, no interaction effect (group-by-time) was identified, and the observed responses were independent of the level of medication.CONCLUSIONS:For this preliminary study, patients with acute lumbar sciatica secondary to disc herniation who received 2 weeks of lumbar traction reported reduced radicular pain and functional impairment and improved well-being regardless of the traction force group to which they were assigned. The effects of the traction treatment were independent of the initial level of medication and appeared to be maintained at the 2-week follow-up.

Published
2016

39. Periprosthetic fracture in the elderly with anatomic modular cementless hemiarthroplasty

Author

Rémy Coulomb, A. Dupeyron, G. Asencio, A. Dhenin, Pascal Kouyoumdjian, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Université de Montpellier (UM), and Euromov (EuroMov)

Subjects
Male, Reoperation, medicine.medical_specialty, Time Factors, Arthroplasty, Replacement, Hip, Cementless stem, Osteoporosis, Periprosthetic, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Risk Factors, medicine, Humans, Orthopedics and Sports Medicine, Medical history, 030212 general & internal medicine, Aged, Retrospective Studies, 030222 orthopedics, Hip, business.industry, Incidence, Incidence (epidemiology), Retrospective cohort study, Middle Aged, medicine.disease, Femoral Neck Fractures, 3. Good health, Surgery, Periprosthetic fracture, medicine.anatomical_structure, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Lesser Trochanter, Female, Cortical bone, Hip Prosthesis, Hemiarthroplasty, Secondary osteoporosis, Periprosthetic Fractures, business, Follow-Up Studies
Abstract

Background The use of an anatomic cementless stem in hemiarthroplasties for femoral intracapsular proximal fracture has been debated, notably because of bone weakness and/or morphological defects related to osteoporosis. We therefore conducted a retrospective study in subjects over 75 years of age who had received an anatomic stem partially coated with hydroxyapatite. The objectives were to determine: 1) the incidence of periprosthetic fractures (PPFs) and, 2) the influence of anatomic factors, including the Cortical Bone Ratio (CBR) (the relation between the endosteal and external diameter of the femoral diaphysis 10 cm below the lesser trochanter). Hypothesis The risk of PPF with an anatomic cementless implant is greater than with cemented stems. Material and methods We retrospectively analyzed 233 patients followed up for 5 years after their surgery. The stem used was an anatomic stem with a modular neck partially coated with hydroxyapatite. The risk factors examined were age, gender, history of osteoporotic fractures, diverse causes of secondary osteoporosis, and proximal bone stock according to various referenced radiological indices such as the CBR. Results Twenty patients (15%) were lost to follow-up, 74 had died (32%) but did not undergo revision for PPF, 15 of the 139 survivors at the last follow-up (10.8%) had had a PPF, five (3.6%; four females, one male) were early fractures (≤ 2 months after implantation), ten (7.2%; two females, eight males) were late fractures (> 2 months). Male gender was protective for PPF occurrence (RR = 0.129; 95%CI (0.04–0.39); P = 0.0003), whereas secondary factors of osteoporosis (RR = 2.035; 95%CI (1.11–3.72); P = 0.0211), and CBR > 0.49 (RR = 227.42; 95%CI (1.072–48,226.76); P = 0.0471) were found as risk factors of PPF. Discussion The PPF rate was greater than that related to cemented stems, requiring that morphological and clinical factors of bone weakness (collected with the patient history and related to osteoporosis) be taken into account. A CBR > 0.49 requires caution on the use of this type of stem. Level of evidence Level 4. Retrospective study.

Published
2016

40. La kinésithérapie dans le traitement de la scoliose idiopathique de l’adolescent : utile ou pas ?

Author

Arnaud Dupeyron, M. Porte, Jérôme Cottalorda, and Karine Patte

Subjects
030506 rehabilitation, medicine.medical_specialty, Rehabilitation, business.industry, medicine.medical_treatment, MEDLINE, Exercise therapy, Idiopathic scoliosis, Scoliosis, medicine.disease, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Pediatrics, Perinatology and Child Health, Physical therapy, Medicine, Respiratory function, 0305 other medical science, business, Physical therapist, 030217 neurology & neurosurgery
Abstract

Many practitioners, pediatricians, and general practitioners prescribe physical therapy when tracking scoliosis. However, has physical therapy alone proved its efficacy in the care of the scoliosis to slow down progression? Our purpose is to report the results of a literature review on the effectiveness of rehabilitation in idiopathic scoliosis. No current study presents sufficient scientific proof to validate the efficacy of isolated exercise therapy in scoliosis. Learned societies recognize, however, the efficacy of combining conservative therapy (brace+physiotherapy) in idiopathic scoliosis. Should we then still prescribe rehabilitation without brace treatment? Although physical therapy alone does not seem effective in treating scoliosis, it can limit potential painful phenomena and be beneficial for respiratory function. The physical therapist can also teach the teenager the classic principles of hygiene of the back. It may therefore be appropriate to prescribe physical therapy, but the principles and objectives must be explained to the patient and family in light of current evidence-based medicine.

Published
2016

41. THU0538 Patients with chronic low back painoriented to functional restoration program are younger, with higher smoking and longer sick leave: a cross- sectional study of 166 patients

Author

Florian Bailly, Laure Gossec, Violaine Foltz, Pierre Letellier, B. Duplan, Marina Assadourian, I. Griffoul-Espiltalier, M. Le Ralle, N. Ibrahim, Sophia Ascione, Bruno Fautrel, Johann Beaudreuil, Antoine Potel, Laetitia Morardet, and Arnaud Dupeyron

Subjects
medicine.medical_specialty, Cross-sectional study, business.industry, Low back pain, Chronic low back pain, Sick leave, medicine, Physical therapy, Anxiety, In patient, Observational study, medicine.symptom, business, Low back
Abstract

Background Functional Restoration Programs (FRP) are multi-disciplinary programs that have demonstrated effectiveness to promote functional status and return to work in patients with chronic low back pain (cLBP)1; 2; 3 and moderate or high disability. Objectives To explore the characteristics of cLBP patients oriented or not towards a FRP. Methods This was an observational cross-sectional, multi-centric study in France in 2017. Consecutive patients with cLBP (>6 weeks) with or without radiculalgia, aged 18–66 years and visiting the rheumatologist for cLBP were included. Patient and disease characteristics were collected. Patients oriented or not towards a FRP were compared in particular for demographic characteristics, duration of sick leave over the past 12 months, smoking, ongoing aerobic physical activity (patient-reported as 40%) and kinesiophobia (Tampa Kinesiophobia Scale≥40). Results In all, 166 patients were analysed: median age 48 years, median cLBP duration 5 years, and 100 (60%) were females. Overall, 62 (37%) were proposed for a FRP. Patients oriented towards a FRP, versus not, were more frequently male (50% vs 44%, p=0.04), younger (median 46 vs 52 years, p=0.02), and had lower pain levels (median 6 vs 7 of 0–10 numeric scale, p=0.006). They had longer sick leave (mean 18 vs 10 weeks/year, p=0.006), were more frequently smokers (33% vs 23%, p=0.02), had similar pain duration (60 month vs 72, p=0.32), functional disabilities (39% vs 49%, p=0.22), kinesiophobia (62% vs 55%, p=0.65), anxiety (52% vs 55%, p=0.60) and depression score (40% vs 35%, p=0.54), but less physical activity practice (38% vs 54%, p=0.04). Conclusions Patients oriented towards a FRP were younger and more often males, with higher smoking and longer sick leave. It appears that kinesiophobia, functional status and duration of low back pain didn’t influence the orientation toward a FRP. More comprehensive assessments of patients with cLBP are needed; multifactorial questionnaires such as StartBack or BP2 may be useful to orient patients towards FRPs. References [1] Poulain C, et al. Eur Spine J2010Jul;19(7):1153–61. [2] Veron O, et al. Ann Readapt Med Phys2008;51(8):642–9. [3] Roche-Leboucher, et al. Spine2011Dec 15;36(26):2235–42. Disclosure of Interest None declared

Published
2018

42. THU0536 Knowledge of and expectations about functional restoration program for chronic low back pain are often false: a mirror survey of 40 patients and 59 physicians in 2017

Author

Isabelle Griffoul-Espitalier, Marina Assadourian, B. Duplan, N. Ibrahim, Violaine Foltz, Bruno Fautrel, Johann Beaudreuil, Antoine Potel, M. Le Ralle, Laetitia Morardet, Sophia Ascione, L. Pierre, Arnaud Dupeyron, Florian Bailly, and Laure Gossec

Subjects
medicine.medical_specialty, Health professionals, business.industry, Physical therapy, medicine, Physical activity, Lack of knowledge, Pain management, Return to work, business, human activities, Chronic low back pain, Test (assessment)
Abstract

Background Functional restoration programs (FRP) are multi-disciplinary programs that have demonstrated their effectiveness in chronic low back pain (CLBP) but they appear to be little known by patients and/or physicians. Objectives To assess the knowledge and expectations of CLBP patients and physicians about FRP. Methods Multicenter cross-sectional study in 2017 in 6 tertiary-care hospitals in France. Consecutive patients with CLBP (more than 6 weeks) who were seen for their CLBP were included. Physicians (rheumatologists or general practitioners, GPs) who had referred at least 5 patients to the tertiary-care centres were sent a survey. Patients and physicians were asked about their knowledge and expectations of a FRP. Results were scored as ‘correct’ regarding health professionals involved in the FRP, if both doctors and (physiotherapists or physical activity coach) were ticked; and ‘correct’ for duration if 3 to 6 weeks. Expectations regarding the FRP were rated on a list of potential expectations on a scale of 0–10. Expectations were scored ‘ correct’ if return to work was scored ≥7/10, and ‘fully correct’ if physical activity and pain management, but not ‘healing’ were also expected. Responses were then compared between patients and physicians by Chi 2 test. Results Of 172 patients, median age 48 years (IQR 38–58), median CLBP duration 5 years (IQR 2–10), 60.0% women: 110 (64.0%) had no knowledge of FRP; 22 had already participated in an FRP. The remaining 40 patients were compared to physicians (figure 1). Of 80 physicians, 42.5% GPs and 53.7% rheumatologists, 57.5% women: 21 (26.2%) had no knowledge of FRP (p value Knowledge of FRP health professionals was ‘correct’ for 13/40 (32.5%) patients vs 41/59 (69.5%) physicians (p=0.0003); and knowledge of duration was ‘correct’ for 26/40 (65.0%) vs 46/59 (78.0%) physicians (p=0.15). Expectations were ‘correct’ for 21/40 (52.5%) patients vs 44/59 (74.6%) for physicians (p=0.02), and ‘fully correct’ for 9/40 (22.5%) patients vs 16/59 (27.1%) for physicians (p=0.6). Conclusions FRP was largely unknown to patients with CLBP. Even those who were aware of the FRP did not know what to expect. While physicians’ knowledge and perception of the FRP was better, there was still a lack of knowledge and therefore a likely underutilization or misuse of the FRP. Information campaigns are needed. Disclosure of Interest None declared

Published
2018

43. Inertial measurement unit compared to an optical motion capturing system in post-stroke individuals with foot-drop syndrome

Author

Feuvrier, François, Sijobert, Benoît, Froger, Jérome, Azevedo Coste, Christine, Griffiths, Karolina M., Alonso, Sandrine, Dupeyron, Arnaud, Laffont, Isabelle, Froger, Jérôme, Hôpital Universitaire de Réadaptation, de Rééducation et d'Addictologie du CHU de Nîmes [Grau-du-Roi] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Unité de Rééducation Neurologique, Centre Hélio-Marin CHU Nîmes, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), BESPIM, Euromov (EuroMov), Université de Montpellier (UM), CCSD, Accord Elsevier, and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM)

Subjects
Male, 030506 rehabilitation, Foot drop, Pilot Projects, 0302 clinical medicine, Accelerometry, Orthopedics and Sports Medicine, Prospective Studies, Range of Motion, Articular, Stroke, Gait, Foot-drop, Aged, 80 and over, Rehabilitation, Stroke Rehabilitation, Syndrome, Middle Aged, Functional electrostimulation, Biomechanical Phenomena, medicine.anatomical_structure, Inertial measurement unit, Female, medicine.symptom, 0305 other medical science, Gait Analysis, Algorithms, medicine.medical_specialty, Correlation coefficient, Mean squared error, Electric Stimulation Therapy, [SPI.AUTO]Engineering Sciences [physics]/Automatic, 03 medical and health sciences, Motion, Physical medicine and rehabilitation, Spatio-Temporal Analysis, medicine, Functional electrical stimulation, Humans, Gait Disorders, Neurologic, Aged, business.industry, Foot, Reproducibility of Results, medicine.disease, [SPI.AUTO] Engineering Sciences [physics]/Automatic, Kinematic parameters, Ankle, business, human activities, 030217 neurology & neurosurgery, Arithmetic mean
Abstract

Functional electrical stimulation (FES) can be used for compensation of foot-drop for post-stroke individuals by pre-programmed fixed stimulation; however, this stimulation seems no more effective than mechanical ankle foot orthoses.We evaluated the metrological quality of inertial sensors for movement reconstruction as compared with the gold-standard motion capturing system, to couple FES with inertial sensors to improve dorsiflexion on the paretic side, by using an adaptive stimulation taking into account individuals' performance post-stroke.Adults with ischemic or hemorrhagic stroke presenting foot-drop and able to walk 10m, were included from May 2016 to June 2017. Those with passive ankle dorsiflexion0° with the knee stretched were excluded. Synchronous gait was analyzed with the VICON© system as the gold standard and inertial measurement units (IMUs) worn by participants. The main outcome was the dorsiflexion angle at the heel strike and mid-swing phase obtained from IMUs and the VICON system. Secondary outcomes were: stride length, walking speed, maximal ankle dorsiflexion velocity and fatigue detection.We included 26 participants [18 males; mean age 58 (range 45-84) years]. During heel strike, the dorsiflexion angle measurements demonstrated a root mean square error (RMSE) of 5.5°; a mean average error (MAE) of 3.9°; Bland-Altman bias of -0.1° with limits of agreement -10.9° to+10.7° and good intra-class correlation coefficient (ICC) at 0.87 between the 2 techniques. During the mid-swing phase, the RMSE was 5.6; MAE 3.7°; Bland-Altman bias -0.9° with limits of agreement -11.7° to+9.8° and ICC 0.88. Good agreement was demonstrated for secondary outcomes and fatigue detection.IMU-based reconstruction algorithms were effective in measuring ankle dorsiflexion with small biases and good ICCs in adults with ischemic or hemorrhagic stroke presenting foot-drop. The precision obtained is sufficient to observe the fatigue influence on the dorsiflexion and therefore to use IMUs to adapt FES.

Published
2018

44. Intensive spa and exercise therapy program for returning to work for low back pain patients: a randomized controlled trial

Author

Arnaud Dupeyron, Christelle Nguyen, Serge Poiraudeau, Clémence Palazzo, Gabriel Baron, Jean-Max Tessier, François Rannou, Katherine Sanchez, Bénédicte Eschalier, Ygal Attal, Isabelle Boutron, Christopher Rein, Marie-Martine Lefèvre-Colau, Romain Forestier, Emmanuel Coudeyre, Christian-François Roques-Latrille, Service de rééducation et de réadaptation de l'appareil locomoteur et des pathologies du rachis [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Sorbonne Paris Cité (USPC), Université Paris Descartes - Paris 5 (UPD5), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Faculté des Sciences Fondamentales et Biomédicales (UPD5 Sciences), Centre d'épidémiologie Clinique [Hôtel-Dieu], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Hôtel Dieu, Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 4 : ECaMO - Épidémiologie clinique appliquée aux maladies rhumatismales et musculo-squelettiques (CRESS - U1153), Institut fédératif de recherche sur le handicap / Réseau fédératif de recherche sur le handicap (IFRH / RFRH), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Montpellier 1 (UM1)-Institut national d'études démographiques (INED)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Bordeaux Segalen - Bordeaux 2-Université de Lille, Sciences et Technologies-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Paris Diderot - Paris 7 (UPD7)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-INST GARCHES-CTNERHI-Université de Lille, Sciences Humaines et Sociales-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Montpellier (UM)-Sorbonne Université (SU)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Euromov (EuroMov), Université de Montpellier (UM), Auteur indépendant, CHU Clermont-Ferrand, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Hôtel Dieu, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Sorbonne Paris Cité (USPC), Université Panthéon-Sorbonne (UP1)-Université Montpellier 1 (UM1)-Institut national d'études démographiques (INED)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Bordeaux Segalen - Bordeaux 2-Université de Lille, Sciences et Technologies-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Université Polytechnique Hauts-de-France (UPHF)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Paris Diderot - Paris 7 (UPD7)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-INST GARCHES-CTNERHI-Université de Lille, Sciences Humaines et Sociales-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Université de Rennes 2 (UR2), Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Paris Diderot - Paris 7 (UPD7)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-INST GARCHES-CTNERHI-Université de Lille, Sciences Humaines et Sociales-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Université de Rennes 2 (UR2), and Nguyen, Christelle

Subjects
Male, medicine.medical_specialty, Randomization, Médecine humaine et pathologie, lcsh:Medicine, Relaxation Therapy, Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, Return to Work, Quality of life, Randomized controlled trial, law, medicine, Humans, 030212 general & internal medicine, lcsh:Science, Multidisciplinary, business.industry, lcsh:R, Exercise therapy, Middle Aged, Low back pain, 3. Good health, Exercise Therapy, Treatment Outcome, Sick leave, Usual care, Physical therapy, Human health and pathology, lcsh:Q, Female, medicine.symptom, business, Educational program, Low Back Pain, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

We aimed to determine whether a 5-day intensive inpatient spa and exercise therapy and educational program is more effective than usual care in improving the rate of returning to work at 1 year for patients with subacute and chronic low back pain (LBP) on sick leave for 4 to 24 weeks. We conducted a 12-month randomized controlled trial. LBP patients were assigned to 5-day spa (2 hr/day), exercise (30 min/day) and education (45 min/day) or to usual care. The primary outcome was the percentage of patients returning to work at 1 year after randomization. Secondary outcomes were pain, disability and health-related quality of life at 1 year and number of sick leave days from 6 to 12 months. The projected recruitment was not achieved. Only 88/700 (12.6%) patients planned were enrolled: 45 in the spa therapy group and 43 in the usual care group. At 1 year, returning to work was 56.3% versus 41.9% (OR 1.69 [95% CI 0.60–4.73], p = 0.32) respectively. There was no significant difference for any of the secondary outcomes. However, our study lacked power.

Published
2017

45. OXIDATIVE STRESS AND MITOCHONDRIAL DYNAMICS MALFUNCTION ARE LINKED IN PELIZAEUS-MERZBACHER DISEASE

Author

Odile Boespflug-Tanguy, Marie-Noëlle Bonnet-Dupeyron, Mélina Bégou, Johan Auwerx, Jone López-Erauskin, Aurora Pujol, Nathalie Launay, Céline Guéret-Gonthier, Catherine Vaurs-Barrière, Pablo Ranea-Robles, Patrizia Bianchi, Stéphane Fourcade, Bérengère Petit, Laia Morató, Montserrat Ruiz, Cristina Guilera, Neuro-Dol (Neuro-Dol), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Pharmacologie fondamentale et clinique de la douleur, Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Laboratory of Integrative and Systems Physiology (LISP), Ecole Polytechnique Fédérale de Lausanne (EPFL), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neuro-Dol - Clermont Auvergne (Neuro-Dol), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité Mixte de Recherches sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA), Génétique, Reproduction et Développement - Clermont Auvergne (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuro-Dol - Clermont Auvergne ( Neuro-Dol ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Clermont Auvergne ( UCA ), Neuro-Dol ( Neuro-Dol ), Université d'Auvergne - Clermont-Ferrand I ( UdA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université d'Auvergne - Clermont-Ferrand I ( UdA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité Mixte de Recherches sur les Herbivores ( UMR 1213 Herbivores ), VetAgro Sup ( VAS ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique ( INRA ), Génétique, reproduction et développement ( GReD ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR79-Université d'Auvergne - Clermont-Ferrand I ( UdA ) -Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ), Laboratory of Integrative and Systems Physiology ( LISP ), Ecole Polytechnique Fédérale de Lausanne ( EPFL ), Institut de génétique et biologie moléculaire et cellulaire ( IGBMC ), and Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
Male, 0301 basic medicine, Proteolipid protein 1, Pelizaeus-Merzbacher Disease, [SDV]Life Sciences [q-bio], experimental autoimmune encephalomyelitis, Mitochondrion, medicine.disease_cause, Mitochondrial Dynamics, Pelizaeus‐Merzbacher disease, Myelin, 0302 clinical medicine, oxidative stress, alzheimers-disease, Child, Cells, Cultured, Research Articles, ComputingMilieux_MISCELLANEOUS, General Neuroscience, Neurodegeneration, Mitochondria, Rare diseases, 3. Good health, Myelin proteolipid protein, Cell biology, antioxidants, medicine.anatomical_structure, Spinal Cord, multiple-sclerosis, Child, Preschool, Malalties rares, axonal degeneration, Research Article, Estrès oxidatiu, Glutamic Acid, Mice, Transgenic, Oxidative phosphorylation, Biology, DNA, Mitochondrial, energy-metabolism, Pathology and Forensic Medicine, Mitochondrial Proteins, 03 medical and health sciences, medicine, Animals, Humans, RNA, Messenger, Myelin Proteolipid Protein, [ SDV ] Life Sciences [q-bio], bioenergetic failure, Infant, Pelizaeus–Merzbacher disease, proteomic identification, Fibroblasts, medicine.disease, Mice, Inbred C57BL, transgenic mouse model, 030104 developmental biology, Oxidative stress, central-nervous-system, x-adrenoleukodystrophy, Neurology (clinical), 030217 neurology & neurosurgery
Abstract

Pelizaeus‐Merzbacher disease (PMD) is a fatal hypomyelinating disorder characterized by early impairment of motor development, nystagmus, choreoathetotic movements, ataxia and progressive spasticity. PMD is caused by variations in the proteolipid protein gene PLP1, which encodes the two major myelin proteins of the central nervous system, PLP and its spliced isoform DM20, in oligodendrocytes. Large duplications including the entire PLP1 gene are the most frequent causative mutation leading to the classical form of PMD. The Plp1 overexpressing mouse model (PLP‐tg66/66) develops a phenotype very similar to human PMD, with early and severe motor dysfunction and a dramatic decrease in lifespan. The sequence of cellular events that cause neurodegeneration and ultimately death is poorly understood. In this work, we analyzed patient‐derived fibroblasts and spinal cords of the PLP‐tg66/66 mouse model, and identified redox imbalance, with altered antioxidant defense and oxidative damage to several enzymes involved in ATP production, such as glycolytic enzymes, creatine kinase and mitochondrial proteins from the Krebs cycle and oxidative phosphorylation. We also evidenced malfunction of the mitochondria compartment with increased ROS production and depolarization in PMD patient's fibroblasts, which was prevented by the antioxidant N‐acetyl‐cysteine. Finally, we uncovered an impairment of mitochondrial dynamics in patient's fibroblasts which may help explain the ultrastructural abnormalities of mitochondria morphology detected in spinal cords from PLP‐tg66/66 mice. Altogether, these results underscore the link between redox and metabolic homeostasis in myelin diseases, provide insight into the pathophysiology of PMD, and may bear implications for tailored pharmacological intervention.

Published
2017

46. De la rééducation à la réadaptation, préparer le retour à domicile

Author

Arnaud Dupeyron, Jérôme Froger, Claire Jourdan, Raphaël Gardes, Marie-Christine Dabek, Sophie Petitqueux, Hôpital Universitaire de Réadaptation, de Rééducation et d'Addictologie du CHU de Nîmes [Grau-du-Roi] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Euromov (EuroMov), Université de Montpellier (UM), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
030506 rehabilitation, medicine.medical_specialty, reintegration, Process (engineering), return home, medicine.medical_treatment, education, retour à domicile, récupération, Head trauma, 03 medical and health sciences, recovery, 0302 clinical medicine, Physical medicine and rehabilitation, réinsertion, medicine, Adaptation (computer science), General Nursing, Rehabilitation, Sequela, medicine.disease, Key (cryptography), head trauma, séquelle, 0305 other medical science, Psychology, sequela, 030217 neurology & neurosurgery, traumatisme crânien, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; After a serious head trauma, the return home constitutes a key moment in the patient's reintegration. It is prepared by a multi-disciplinary team throughout the rehabilitation and re-adaptation process, taking into account the patient's prognosis for recovery.

Published
2017

47. Educational self-care objectives within a functional spine restoration program. Retrospective study of 104 patients

Author

Claire Duflos, Arnaud Dupeyron, Bao Tran, Isabelle Tavares Figueiredo, Christian Hérisson, Emmanuel Coudeyre, Marc Julia, Département de Médecine Physique et de Réadaptation [Montpellier], Hôpital Lapeyronie [Montpellier] (CHU), Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), CHU Clermont-Ferrand, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), and Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université

Subjects
Adult, Male, Program evaluation, Biopsychosocial model, medicine.medical_specialty, Self-Evaluation Programs, Time Factors, medicine.medical_treatment, computer.software_genre, Functional restoration of the spine, 03 medical and health sciences, 0302 clinical medicine, Patient Education as Topic, Educational assessment, Bio-psychosocial, medicine, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, Pain Measurement, Retrospective Studies, Chronic low-back pain, Rehabilitation, business.industry, Retrospective cohort study, Middle Aged, Low back pain, Exercise Therapy, Self Care, Self care, Physical therapy, Female, medicine.symptom, Self-care, business, Low Back Pain, computer, Inclusion (education), 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Program Evaluation
Abstract

International audience; BACKGROUND:Defining individual educational, or learning, targets is part of the initial educational assessment in rehabilitation programs, but no data are available on how to achieve these goals.OBJECTIVE:We aimed to evaluate whether educational objectives established with the patient as part of a functional spine restoration program integrating self-care sessions were met after the program and associated therapy outcomes.METHODS:This retrospective study involved 104 patients with chronic low-back pain who participated in a self-care rehabilitation program between 2008 and 2012. The program included both physical and educational approaches to dealing with the condition. The main evaluation criterion was achieving the educational objectives established with the patient at 6 months. Secondary criteria were a return to work, pain intensity and impact on function, satisfaction with the program and implementation of physical activity and self-rehabilitation at 6 months.RESULTS:At 6 months, 55% of the established educational objectives were fully achieved and satisfaction was close to 90%. Significantly, more patients were involved in a physical activity at 6 and 12 months and self-rehabilitation exercises at 6 months as compared with at inclusion. Overall, 43.4% were working at inclusion, 64.2% at 6 months and 58.2% at 12 months (P

Published
2016

48. Combining balneotherapy and health promotion to promote active and healthy ageing: the Balaruc-MACVIA-LR® approach

Author

Jean Bousquet, L. Soriteau, H. Solimene, T. Camuzat, Hubert Blain, Christian Hérisson, Isabelle Quéré, P.L. Bernard, Jacques Mercier, M. Nogues, G. Canovas, Arnaud Dupeyron, N. Raffort, Isabelle Laffont, H. Desfour, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Euromov (EuroMov), Université de Montpellier (UM), Mairie, Société Publique Locale d'Exploitation de Balaruc-les-Bains, Balaruc-Les-Bains, CARSAT-LR, Montpellier, Région Languedoc-Roussillon-Midi-Pyrénées, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), and University of Milan

Subjects
Gerontology, Balneotherapy, medicine.medical_specialty, Aging, 010504 meteorology & atmospheric sciences, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Alternative medicine, Health Promotion, Review, 01 natural sciences, Education, 03 medical and health sciences, 0302 clinical medicine, Patient Education as Topic, Musculoskeletal disease, medicine, Humans, 030212 general & internal medicine, Musculoskeletal Diseases, Hydrotherapy, Exercise, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, business.industry, Balneology, Climatotherapy, 3. Good health, Integrated care, Europe, Ageing, Health promotion, General partnership, Chronic Disease, Physical therapy, Accidental Falls, Falls, Healthy ageing, Geriatrics and Gerontology, business
Abstract

Scaling up and replication of successful innovative integrated care models for chronic diseases is one of the targets of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). MACVIA-LR® (MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon) is a Reference Site of the EIP on AHA. The main objective of MACVIA-LR® is to develop innovative solutions in order to (1) improve the care of patients affected by chronic diseases, (2) reduce avoidable hospitalization and (3) scale up the innovation to regions of Europe. The MACVIA-LR® project also aims to assess all possible aspects of medicine—including non-pharmacologic approaches—in order to maintain health and prevent chronic diseases. These approaches include hydrotherapy and balneotherapy which can be of great importance if health promotion strategies are considered. Balneotherapy at Balaruc-les-Bains focusses on musculoskeletal diseases and chronic venous insufficiency of the lower limbs. Each year, over 46,000 people attend an 18-day course related to a new falls prevention initiative combining balneotherapy and education. On arrival, each person receives a flyer providing information on the risk of fall and, depending on this risk, a course is proposed combining education and physical activity. A pilot study assesses the impact of the course 6 and 12 months later. This health promotion strategy for active and healthy ageing follows the FEMTEC (World Federation of Hydrotherapy and Climatotherapy) concept.

Published
2016

49. [Living Lab MACVIA-LR. Equilibrium and the prevention of falls]

Author

Gregoire Mercier, B. Alomène, M. Lapierre, J. Pelissier, E. Viollet, J.L. Savy, F. Nouvel, Michel Amouyal, E. Royère, E. Roux, O. Engberink, Olivier Jonquet, J.M. Lussert, D. Jakovenko, Didier Delignières, Arnaud Dupeyron, S. Perrey, F. Abecassis, T. Akbaraly, G. Tallon, P.A. Adnet, F. Gressard, E. Pastor, N. Pinto, T. Camuzat, G. Dupeyron, D. Strubel, A. Matheron, Marie-Christine Picot, G. Baptista, S. Granier, Claude Jeandel, C. Boubakri, M.P. Pasdelou, Bernard Combe, G. Canovas, N. Raffort, Yannick Stephan, Jerôme Morel, Vivien Marmelat, A. Bedbrook, Rodolphe Bourret, I. Rédini-Martinez, P.L. Bernard, Isabelle Laffont, Jacques Mercier, Benoît G. Bardy, Hubert Blain, C. Laurent, M. Aoustin, Grégory Ninot, J. Burille, P. Domy, Béatrice Lognos, Jacques Bringer, M.V. Calmels, Grégoire Vergotte, M. Nogues, Jean-Marie Robine, Kjerstin Torre, Kevin Mandrick, J.-E. de La Coussaye, Sofiane Ramdani, M.P. Battesti, P. Martin-Gousset, D. Heve, Jean Bousquet, M.S. Léglise, Christine Meunier, F. Radier-Pontal, Jean-Michel Verdier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Euromov (EuroMov), Université de Montpellier (UM), Hôpital Universitaire de Réadaptation, de Rééducation et d'Addictologie du CHU de Nîmes [Grau-du-Roi] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Agence Régionale de la Santé (ARS), Société Publique Locale d'Exploitation de Balaruc-les-Bains, Balaruc-Les-Bains, Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Dynamique des capacités humaines et des conduites de santé (EPSYLON), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Montpellier (UM), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut méditerranéen des métiers de la longévité (I2ML), Institut méditerranéen des métiers de la longévité, Caisse d'assurance retraite et de la santé au travail, CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-École des hautes études en sciences sociales (EHESS), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Rééducation et réadaptation neurologique [CHU de Nîmes - Hôpital du Grau-du-Roi], Hôpital Universitaire de réadaptation, de Rééducation et d'Adictologie du CHU de Nîmes [Grau-du-Roi], Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), Université Montpellier 2 - Sciences et Techniques (UM2)-École pratique des hautes études (EPHE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UM3)-Université de Montpellier (UM), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UM 7 (UMR 8211 / U988)), Université de Montpellier (UM)-Université Montpellier 1 (UM1), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Geriatrics, Gerontology, medicine.medical_specialty, business.industry, Public health, MEDLINE, Information Dissemination, General Medicine, 03 medical and health sciences, 0302 clinical medicine, Health promotion, Cost of illness, medicine, Postural Balance, 030212 general & internal medicine, business, 030217 neurology & neurosurgery, Independent living, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

La Presse Medicale - In Press.Proof corrected by the author Available online since vendredi 16 octobre 2015

Published
2015

50. Le site de référence du Partenariat européen d’innovation pour un vieillissement actif et en bonne santé MACVIA-LR (contre les maladies chroniques pour un vieillissement en bonne santé en Languedoc-Roussillon)

Author

Miren David, Ariane Sultan, Guillaume Pandraud, Benoît G. Bardy, Jacques Morel, Giacomo Cavalli, Sylvain Jacquemin, Christine Rolland, Cyril Breuker, Philippe Boulet, Gregoire Mercier, Stéphane Bouly, Valérie Bruguière, Gwen Mathieu, Marc Meissonnier, Hervé Tassery, Vincent Marmelat, Michel Dauzat, Hubert Blain, Gérard Dray, Cyril Laurent, Christine Viarouge-Reunier, Marie Virginie Calmels, François Rivier, Gérard Dupeyron, Gérard Bourrel, Jacquie Berthe, Philippe Domy, Béatrice Lognos, Martine Aoustin, Davide Caimmi, Michel Kaczorek, Mélanie Badin, Pierre Nicolas, Alain Le Quellec, Sylvie Boichot, Vincent Le Moing, C. Boegner, Jérôme Fernandes, Michel Amouyal, Matthieu Desplan, Jean Paul Cristol, T. Camuzat, Karima Bakhti, Jean Michel Verdier, Paule Adnet, Christophe Jorgensen, Denis Sablot, Jean Ribstein, Henriette Dhivert-Donnadieu, Céline Vergne-Richard, Emilie Porte, Christine Azevedo, Isabelle Quéré, Dominique Jakovenko, Marion Gellerat-Rogier, Michel Tanfin, Karen Ritchie, Flavia Oana Coroian, Bernard Guillot, Fabrice Nouvel, J. Pelissier, Anna Bedbrook, Daniel Laune, Jean-Luc Bourrain, Yves Marie Pers, Jean Luc Savy, Chantal Marion, Cherif Heroum, Marianna Danko, Grégoire Vergotte, Françoise Radier-Pontal, Jean Luc Pasquié, Olivier Bénézet, Bernard Combe, Sylvain Richard, Liliane Landreau, Valérie Cros, Isabelle Rédini-Martinez, Emilie Viollet, David Guiraud, François Roubille, Jérôme Froger, Bertrand Coulet, Laurent Journot, Marie Suzanne Léglise, Sylvie Arnavieilhe, Isabel Tavares, Samir Jaber, Olivier Jonquet, David Morquin, Philippe Van de Perre, Roland Sicard, Raphaël Chiron, Vincent Tribout, Pierre Senesse, Xavier Quantin, Jacques Touchon, Kevin Mandrick, Alain Uziel, Vincent Bouix, Marie Christine Picot, Philippe Augé, Martine Lapierre, Antoine Avignon, Eric Pastor, Pascal Demoly, Kjerstin Torre, Jacques Mercier, Jean-Marie Robine, Dominique Larrey, D. J. Costa, Grégory Ninot, Laurent Schifano, Baya Soua, Anne Wojtusciszyn, Jean-Christophe Gris, Didier Delignières, Florence Gressard, Marie Pierre Pasdelou, Fabienne Portejoie, Michel Mondain, Philippe Nérin, Olivier Hantkié, Xavier Bobia, Delphine Paccard, Pierre Géraud Claret, Maxime Villiet, Jacques Burille, Christian Hérisson, Guillaume Tallon, V. Attalin, Jean Emmanuel de la Coussaye, William Camu, Didier Hoa, Chokri Boubakri, Jacques Reynes, Michel Enjalbert, Pascal Kouyoumdjian, Anthony Gellis, Jean Marc Lussert, Jean Philippe Pin, Christian Bourquin, Jean-Marc Lemaitre, Rodolphe Bourret, Isabelle Laffont, Claudine Berr, Marie Christine Courrouy-Michel, Nicolas Giraudeau, Trias Asteriou, Catherine Leblond, Cyril Meunier, Sylvain Lehmann, M. Nogues, Denise Strubel, Raul Punta-Morales, Alain Makinson, Jacques Bringer, Stéphane Perrey, Nathalie Pinto, Yannick Stephan, Charles Fattal, Jean Marc Davy, Arnaud Bourdin, Emilie Royère, Arnaud Dupeyron, Claire Daien, François Vialla, Frédéric Viart, Joël Bockaert, Arnaud Yves Goucham, Pierre Aubas, Huei Yune Bonnin, Fares Gouzi, Véronique Carre, Nicolas Best, Jean Pierre Riso, Jérome Cottalorda, Max Villain, Philippe Dauenhauer, Patrick Messner, Amélie Matheron, Claude Jeandel, Roxana Taddei-Ologeanu, Bernard Alomène, Sylvie Albert, Stéphane Cade, Gérard Canovas, Pauline Coignard, Karine Patte, Sofiane Ramdani, Frédéric Abecassis, Maurice Hayot, Marc Ychou, Anne Laure Coupet, Nathalie Raffort, D. Heve, Philippe Gabrion, Pierre Mares, Pierre Labauge, Marie Pierre Battesti, Denis Mottet, Philippe Fraisse, Jean Bousquet, Jean Louis Pujol, Emilie Galano, Pierre Fesler, Vincent Dufour, Gregory Baptista, Pierre Louis Bernard, Mireille Fouletier, Pierre Dujol, Xavier Vasquez, Jean Paul Ortiz, Pierre Martin-Gousset, Philippe Courtet, Oude Engberink, Valérie Handweiler, S. Granier, Laurence Vian, Françoise Leclercq, Frédéric Cuisinier, Pierre Costa, Guillaume Cayla, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Département d'anesthésie-réanimation[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier], Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Department of Geriatrics - Efficiency and Deficiency Laboratory, Hadassah Hebrew University Medical Center [Jerusalem], IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT), Département de Biostatistiques, Agence Régionale de Santé Languedoc Roussillon (ARS), Institut de Recherche en Infectiologie de Montpellier (IRIM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Roche Pharma Research and Early Development [Basel] (pRED), F. Hoffmann-La Roche [Basel], Service de gynécologie-obstétrique, Mécanismes adaptatifs : des organismes aux communautés (MAOAC), Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF)-Muséum national d'Histoire naturelle (MNHN), Laboratoire de Géochimie Isotopique Environnementale (GIS) / Université de Nîmes (GIS), Université de Nîmes (UNIMES)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Genre (LARHRA GENRE), LAboratoire de Recherche Historique Rhône-Alpes - UMR5190 (LARHRA), Centre National de la Recherche Scientifique (CNRS)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Grenoble Alpes (UGA), Département de Médecine générale, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Département de médecine générale, Université de Montpellier (UM), Euromov (EuroMov), Centre Européen de Réalité Virtuelle (CERV), École Nationale d'Ingénieurs de Brest (ENIB), Laboratoire de Mathématiques Blaise Pascal (LMBP), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Pathologies du système nerveux : recherche épidémiologique et clinique, Université Montpellier 1 (UM1)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), CERFRANCE Nord Est - Ile de France, Réseau de Vigilance en Dermato-Allergologie - Groupe d'Etudes et de Recherches en DERmato-Allergologie (Revidal-Gerda), Réseau de Vigilance en Dermato-Allergologie (Revidal), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de KERPAPE [Ploemeur] (CMRRF), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape, Laboratoire de Bioingénierie et NanoSciences (LBN), Institut de Génétique Moléculaire de Montpellier (IGMM), Dynamique des capacités humaines et des conduites de santé (EPSYLON), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UM3)-Université de Montpellier (UM), Laboratory of Cardio-Vascular Physiology (LCVP), Université Montpellier 1 (UM1), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Rééducation et Réadaptation Neuro Orthopédique [Nîmes] (Pôle NACRRE), Hôpital Universitaire Carémeau [Nîmes], Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Oc Santé Montpellier, Artificial movement and gait restoration (DEMAR), Unité de Rééducation Neurologique, Centre Hélio-Marin CHU Nîmes, Department de Dermatologie, Médecine physique et de réadaptation, Hôpital Lapeyronie [Montpellier] (CHU), Institut de Génomique Fonctionnelle - Montpellier GenomiX (IGF MGX), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie Orthopédique, Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Centre Bouffard-Vercelli, Laboratoire de Mécanique et Technologie (LMT), École normale supérieure - Cachan (ENS Cachan)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Plateforme de Protéomique Clinique, CHU Saint-Eloi, Recherches Translationnelles sur le VIH et les maladies infectieuses (TransVIHMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Universtié Yaoundé 1 [Cameroun]-Université de Montpellier (UM), Département Conception et conduite des véhicules Aéronautiques et Spatiaux (DCAS), Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO), Lab-STICC_TB_CID_TOMS, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de recherche souterrain de Meuse/Haute-Marne, Agence Nationale de gestion des Déchets Radioactifs, Aix-Marseille Université - Faculté des Sciences du Sport (AMU FSS), Aix Marseille Université (AMU), HORIBA Medical (HORIBA ABX SAS), HORIBA Scientific [France], Unité Mathématique, Informatique et Génome (MIG), Institut National de la Recherche Agronomique (INRA), Interactions, Corpus, Apprentissages, Représentations (ICAR), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-INRP-Ecole Normale Supérieure Lettres et Sciences Humaines-Centre National de la Recherche Scientifique (CNRS), Unité clinique d'Immuno-Rhumatologie & Thérapeutique des maladies ostéo-articulaires, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS), UNICANCER - Institut régional du Cancer [Montpellier] (ICM), CRLCC Val d'Aurelle - Paul Lamarque, Biocommunication en Cardio-Métabolique (BC2M), Neuropsychiatrie : recherche épidémiologique et clinique, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Département d'oncologie médicale et digestive, Centre de cancérologie Val d'Aurelle, Complexité, Innovation, Activités Motrices et Sportives (CIAMS), Université d'Orléans (UO)-Université Paris-Sud - Paris 11 (UP11), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie et thérapie des déficits sensoriels et moteurs, Université Montpellier 2 - Sciences et Techniques (UM2)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche et de Diagnostic sur le Sida (CeDreS), CHU Treichville, Interaction entre Systèmes Protéiques et Différenciation dans la Cellule Tumorale (ISPDCT), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Dynamiques du droit (DD), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Centre National de la Recherche Scientifique (CNRS), Centre de pharmacologie et innovation dans le diabète (CPID), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre National de la Recherche Scientifique (CNRS), Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Gui de Chauliac, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] ( PhyMedExp ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), IMT - Mines Alès Ecole Mines - Télécom ( IMT - MINES ALES ), Agence Régionale de Santé Languedoc Roussillon ( ARS ), Institut de Recherche en Infectiologie de Montpellier ( IRIM ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ), Roche Pharma Research and Early Development [Basel] ( pRED ), Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ), Mécanismes adaptatifs : des organismes aux communautés ( MAOAC ), Muséum National d'Histoire Naturelle ( MNHN ) -Collège de France ( CdF ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Géochimie Isotopique Environnementale (GIS) / Université de Nîmes ( GIS ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Nîmes ( UNIMES ), Institut de recherche en cancérologie de Montpellier ( IRCM ), Université Montpellier 1 ( UM1 ) -CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon ( MACVIA-LR ), Université Montpellier 1 ( UM1 ) -World Health Organization ( WHO/OMS ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -European Innovation Partnership on Active and Healthy Ageing Reference Site, Agence Nationale de Sécurité Sanitaire, de l'Alimentation, de l'environnement et du Travail ( ANSES ), ANSES, Genre ( LARHRA GENRE ), LAboratoire de Recherche Historique Rhône-Alpes - UMR5190 ( LARHRA ), Centre National de la Recherche Scientifique ( CNRS ) -Université Jean Moulin - Lyon III-Université Lumière - Lyon 2 ( UL2 ) -École normale supérieure - Lyon ( ENS Lyon ) -Université Pierre Mendès France - Grenoble 2 ( UPMF ) -Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Jean Moulin - Lyon III-Université Lumière - Lyon 2 ( UL2 ) -École normale supérieure - Lyon ( ENS Lyon ) -Université Pierre Mendès France - Grenoble 2 ( UPMF ) -Université Grenoble Alpes ( UGA ), Université Montpellier 1 ( UM1 ), Artificial movement and gait restoration ( DEMAR ), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier ( LIRMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Université de Montpellier ( UM ), Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Centre Européen de Réalité Virtuelle ( CERV ), École Nationale d'Ingénieurs de Brest ( ENIB ), Laboratoire de Mathématiques Blaise Pascal ( LMBP ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Centre National de la Recherche Scientifique ( CNRS ), Université Montpellier 1 ( UM1 ) -IFR76-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Génomique Fonctionnelle ( IGF ), Centre National de la Recherche Scientifique ( CNRS ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Réseau de Vigilance en Dermato-Allergologie - Groupe d'Etudes et de Recherches en DERmato-Allergologie ( Revidal-Gerda ), Réseau de Vigilance en Dermato-Allergologie ( Revidal ), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de KERPAPE [Ploemeur] ( CMRRF ), Laboratoire de Bioingénierie et NanoScience-UM, Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Institut de Génétique Moléculaire de Montpellier ( IGMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Dynamique des capacités humaines et des conduites de santé ( EPSYLON ), Université Paul-Valéry - Montpellier 3 ( UM3 ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Laboratory of Cardio-Vascular Physiology ( LCVP ), Institut Pierre Louis d'Epidémiologie et de Santé Publique ( iPLESP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Département de Rééducation et Réadaptation Neuro Orthopédique [Nîmes] ( Pôle NACRRE ), Centre Mutualiste de Réeducation Neurologique Propara ( PROPARA ), Hôpital Lapeyronie [Montpellier] ( CHU ), Institut de Génomique Fonctionnelle - Montpellier GenomiX ( IGF MGX ), Laboratoire de Mécanique et Technologie ( LMT ), École normale supérieure - Cachan ( ENS Cachan ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), CHU Saint-Eloi-Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Recherches Translationnelles sur le VIH et les maladies infectieuses ( TransVIHMI ), Université Montpellier 1 ( UM1 ) -Université Cheikh Anta Diop ( UCAD ) -Universtié Yaoundé 1 (Cameroun)-Université de Montpellier ( UM ), Département Conception et conduite des véhicules Aéronautiques et Spatiaux ( DCAS ), Institut Supérieur de l'Aéronautique et de l'Espace ( ISAE-SUPAERO ), Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance ( Lab-STICC ), École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université européenne de Bretagne ( UEB ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ) -École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université européenne de Bretagne ( UEB ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Aix-Marseille Université - Faculté des Sciences du Sport ( AMU FSS ), Aix Marseille Université ( AMU ), HORIBA Medical ( HORIBA ABX SAS ), Unité Mathématique, Informatique et Génome ( MIG ), Institut National de la Recherche Agronomique ( INRA ), Interactions, Corpus, Apprentissages, Représentations ( ICAR ), École normale supérieure - Lyon ( ENS Lyon ) -Université Lumière - Lyon 2 ( UL2 ) -INRP-Ecole Normale Supérieure Lettres et Sciences Humaines-Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Lapeyronie, Institut de Chimie des Substances Naturelles ( ICSN ), Centre National de la Recherche Scientifique ( CNRS ), UNICANCER - Institut régional du Cancer [Montpellier] ( ICM ), Efficience Déficience Motrice [Montpellier] ( EDM ), Centre de pharmacologie et innovation dans le diabète ( CPID ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Centre National de la Recherche Scientifique ( CNRS ), Complexité, Innovation, Activités Motrices et Sportives ( CIAMS ), Université Paris-Sud - Paris 11 ( UP11 ) -Université d'Orléans ( UO ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Montpellier 2 - Sciences et Techniques ( UM2 ) -IFR76-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de recherche et de Diagnostic sur le Sida ( CeDreS ), Interaction entre Systèmes Protéiques et Différenciation dans la Cellule Tumorale ( ISPDCT ), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique ( CNRS ), Dynamiques du droit ( DD ), Centre National de la Recherche Scientifique ( CNRS ) -Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), École des hautes études en sciences sociales (EHESS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Agence Régionale de la Santé (ARS), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Pierre Mendès France - Grenoble 2 (UPMF)-École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Montpellier (UM), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Oc Santé [Montpellier], Interactive Digital Humans (IDH), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Service de Rhumatologie [CHRU Montpellier], École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-INRP-Ecole Normale Supérieure Lettres et Sciences Humaines (ENS LSH)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut du Cancer de Montpellier (ICM), Université Paris-Sud - Paris 11 (UP11)-Université d'Orléans (UO), Centre de recherche et de Diagnostic sur le Sida [Abidjan, Côte d'Ivoire] (CeDreS), Centre Hospitalier Universitaire de Treichville [Abidjan, Côte d'Ivoire] (CHU de Treichville), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 1 (UM1), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1), Muséum national d'Histoire naturelle (MNHN)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), and CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Aging, [ SDV ] Life Sciences [q-bio], business.industry, [SDV]Life Sciences [q-bio], General Medicine, MESH: Accidental Falls, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Medicine, 030211 gastroenterology & hepatology, Accidental Falls, MESH: Aging, 030212 general & internal medicine, business, Humanities, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Le site de référence du Partenariat européen d'innovation pour un vieillissement actif et en bonne santé MACVIA-LR (contre les maladies chroniques pour un vieillissement en bonne santé en Languedoc-Roussillon)

Published
2015

Catalog

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