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1. Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children

Author

Theresa W. Guilbert, Leonard B. Bacharier, David T. Mauger, Wanda Phipatanakul, Stanley J. Szefler, Susan Boehmer, Avraham Beigelman, Anne M. Fitzpatrick, Daniel J. Jackson, Sachin N. Baxi, Mindy Benson, Carey-Ann D. Burnham, Michael D. Cabana, Mario Castro, James F. Chmiel, Ronina Covar, Michael Daines, Jonathan M. Gaffin, Deborah A. Gentile, Fernando Holguin, Elliot Israel, H. William Kelly, Stephen C. Lazarus, Robert F. Lemanske, Ngoc Ly, Kelley Meade, Wayne Morgan, James Moy, J. Tod Olin, Stephen P. Peters, Jacqueline A. Pongracic, Hengameh H. Raissy, Kristie Ross, William J. Sheehan, Christine Sorkness, W. Gerald Teague, Shannon Thyne, Fernando D. Martinez, Lisa Bartnikas, Alisha Bouzaher, Christopher Burke, Matthew Cavanaugh, Julia Chen, Elizabeth Cunningham, Amparito Cunningham, James Friedlander, Enal Hindi, David Kantor, Perdita Permaul, Devako Rao, Melinda Rossi, Doris Schierembergg, Kynda Schneider, Jennifer Troung, Dale Umetsu, Joseph Zhou, Jill Chmielewski, Anna Fishbein, Iliana Flexas, Ramsay Fuleihan, Rajesh Kumar, James Lane, Melanie Makhija, Louis Martos, Brandon Parker, Benjamin Prince, Nashmia Qamar, Mary Riordan, Rachel Robinson, Waheeda Samady, Christine Szychlinski, Daniel Tsang, Christopher Codispoti, Juan Fu, Grace Li, Diana Munoz-Mendoza, Benjamin Thompson, Melanie Gleason, Sakari Graves, Jonathan Malka, Melanie Phillips, Gayle Spears, D. Sundstrom, Michael White, Christina Batson, Lea Davies, Franceska Kelly, Esmeralda Morales, Abby Redway, Mary Spicher, Lauren Kaminski, Megan R. Knutson, Kelly Miller, Jennifer Promer, Sheila Turcsanyi, Tanya Watson, Shean Aujla, John Broyles, Hey Chong, Patricia Dubin, Jonathan Finder, Todd D. Green, Lori Holt, Adam Kufen, Geoffrey Kurland, Rose Lanzo, David Nash, Julianne Parente, Catherine Smith, Jonathan Spahr, Daniel J. Weiner, Daniel Craven, Danielle Goetz, Meeghan Hart, Leigh A. Kerns, Laurie Logan, Ross Myers, Laura Veri, Erica Butler, Jennifer Maiolo, Sara Misplay, David Skoner, Glennys Smith, Wanda Caldwell, Courtney Dula, Alysa Ellis, Caroline Horner, Lila Kertz, Tina Norris, Katherine Rivera-Spoljaric, Oscar Rodriguez, Robert Strunk, Jessica Bowman, Vicky Bowyer, Judy Gonzales-Vargas, Sara Hawkey, Susannah McCormick, Michelle McKean, Dan Shapiro, Katherine Tom, Jason Decker, Keonna Harrison, Dayna Long, Jyothi Marbin, Robert Mok, Cindy Nelson-Purdy, Dennis Ren, Hollie Stessel, Deb Green, Denise Thompson-Batt, Kristin Wavell, Donna Wolf, Timothy Beaty, Alice C. Bruce, Karen DeMuth, Jennifer Dodds, Shaneka Douglas, Dawn M. Simon, Denise Whitlock, Shanae Brown, Matthew Bowman, Loretta Doty, Linda Ferrari, Beth Gern, Dave Mauger, Aimee Merchlinski, James Schmidt, Daniel Tekely, Lindsay Texter, Angela Updegrave, and Ronald Zimmerman

Subjects
Pediatrics, medicine.medical_specialty, Allergy, Adrenal cortex hormones, Immunology, education, MEDLINE, Article, 03 medical and health sciences, 0302 clinical medicine, Adrenal Cortex Hormones, 030225 pediatrics, Administration, Inhalation, and Blood Institute's AsthmaNet, medicine, Immunology and Allergy, Humans, Respiratory sounds, Child, Preschool, Lung, Asthma, Respiratory Sounds, medicine.diagnostic_test, Inhalation, business.industry, National Heart, medicine.disease, Clinical trial, medicine.anatomical_structure, 030228 respiratory system, Child, Preschool, Administration, business
Abstract

Summary This letter addresses the controversial issue of the use of oral corticosteroids during wheezing exacerbations in preschool-aged children by demonstrating findings of a prematurely terminated multi-center clinical trial, discussing lessons learned, and suggesting future directions.

Published
2018

2. Does the ICE scoring system improve practice?

Author

Denise Thompson, Michael H Jones, Archana Shailendra, and Sue Lockwood

Subjects
Clinical audit, Process management, Momentum (finance), Scoring system, Leadership and Management, business.industry, Health Policy, Medicine, Accounting, business, health care economics and organizations
Abstract

The role of clinical audit in the NHS is continuously gaining momentum as an important tool for the maintainence of high standards in an ever-pressing environment of increasing expectations and restricted resources (Jamtvedt et al, 2006). Furthermore, the impact of clinical governance and a need to demonstrate hard evidence of good practice, as well as compliance with clinical guidelines, has highlighted the importance of the audit process.

Published
2008
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3. Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: a randomized clinical trial

Author

Adante Hart, Samang Ung, Callan J. Burzynski, Susan Rappaport, Bennie McWilliams, Elizabeth Lancet, Sabrena Mervin-Blake, Michael O. Daines, Tara F. Carr, Jennifer Kustwin, David M. Shade, Nicholas Eberlein, Elise Pangborn, Connie Romaine, Ellen D. Brown, Patricia D. Rebolledo, Andre Rogatko, Anna Adler, Adam Wanner, Stephanie M. Burns, Jonathan Cruse, Deanna M. Green, Janette C. Priefert, Gail Weinmann, W. Gerald Teague, John Welter, Deborah Keaney Chassaing, Leonard B. Bacharier, Tonya Greene, Nienchun Wu, Daniel A. Searing, Edward T. Naureckas, Lilian Cadet, Jason E. Lang, Laura Bertrand, Weijiang Shen, Robert A. Wise, April Thurman, Janet Hutchins, Andrea Lears, Amber Martineau, John S. Sundy, Nancy Prusakowski, Christine A. Sorkness, Kaharu Sumino, Nina Phillips, Andreas Schmid, Flavia C.L. Hoyte, Silvia Lopez, Marie C. Sandi, Cristine E. Berry, Edward B. Mougey, Gwen Leatherman, Scott H. Sicherer, Lisa Monchil, Lucius Robinson, Dima Ezmigna, Gang Zheng, Paula J. Puntenney, Joan Reibman, V. Susan Robertson, Lisa Webber, Nicholas R. Anthonisen, Blanca A. Lopez, Michael F. Land, Kristina Rivera, Jessica Ghidorzi, Denise Thompson-Batt, Christian Bime, Brian P. Vickery, Xavier Soler, Marilyn Scharbach, Agnes Banquet, Johana Arana, Richard S. Tejedor, Suzanna Roettger, Jonathan P. Parsons, Ben Xu, Ankoor S. Shah, Denise Jaggers, Thomas Lahiri, Eliana S. Mendes, Lucy Wang, Eveline Y. Wu, David Cosmar, Gary I. Salzman, Elizabeth De La Riva-Velasco, Alicia Newcomer, John G. Mastronarde, Elizabeth A. Sugar, Razan Yasin, Mary A. Nevin, Fernando D. Martinez, Anne S Casper, Melissa M. Scheuerman, William J. Calhoun, Jesus A. Wences, James N. Moy, Virginia S. Taggart, Nicola A. Hanania, Anne E. Dixon, Asem Abdeljalil, William C. Bailey, Jessica Williams, Monroe J. King, Sarah M. Croker, Kenneth S. Knox, Mary Warde, Rubin I. Cohen, Sankaran Krishnan, Mario Castro, Newel Bryce-Robinson, Karen Carapetyan, Christine Y. Wei, Roni Grad, Stephen C. Lazarus, Nancy Busk, Patti Haney, Richard F. Lockey, Lewis J. Smith, Michael Campos, Jaime Tarsi, Wayne J. Morgan, James L. Goodwin, Norman H. Edelman, Charles G. Irvin, Noopur Singh, Janet T. Holbrook, Johnson Ukken, David A. Kaminsky, Ravi Kalhan, Kyle I. Happel, Joe Ramsdell, Mustafa A. Atik, Nancy Archer, Raymond G. Slavin, Maria Teresa Santiago, Paul Ferguson, Virginia Zagaja, Rachael A. Compton, Joseph Santiago, Katherine Chee, Brenda M. Patterson, Ramona Ramdeo, Monica T. Varela, Joseph Boyer, Allen J. Dozor, Catherine M Foss, Robert Smith, Michael Busk, Maureen Dreyfus, Marie Daniel, Sobharani Rayapudi, Shirley McCullough, Jenny Hixon, Stephen Wasserman, Holly Currier, Andrea Paco, Tara M. Formisano, Nadav Traeger, Ingrid Gherson, Thomas Matthews, Subhadra Siegel, Michelle Freemer, J.N. Saams, Rosemary Weese, Alexis L Rea, Y. Cathy Kim, Michelle M. Cloutier, Deborah Nowakowski, Kristin W. Wavell, Dennis Pyszczynski, Kathryn V. Blake, Peter J. Kahrilas, Marianna Sockrider, Rohit K. Katial, Mark A. Brown, Suzette T. Gjonaj, Zenobia Gonsalves, Arleen Antoine, Lynn B. Gerald, Emily DiMango, Linda Rogers, Debra Amend-Libercci, Abbi Brees, Deanna Seymour, Abid Bhat, John J. Lima, Stephanie Allen, Diana B. Lowenthal, Katie Kinninger, Rebecca McCrery, Janice Drake, Cori L. Daines, Charlene Levine, Elizabeth K. Fiorino, Monica M. Vasquez, Terri Montgomery, Donna Wolf, and Trisha Larson

Subjects
Spirometry, Adult, Male, Allergy, medicine.medical_specialty, Adolescent, Placebo, Article, law.invention, Young Adult, Randomized controlled trial, Double-Blind Method, law, Internal medicine, Forced Expiratory Volume, medicine, Humans, Young adult, Child, Lung, Asthma, medicine.diagnostic_test, business.industry, Plant Extracts, General Medicine, Middle Aged, medicine.disease, Genistein, Isoflavones, Clinical research, Exhaled nitric oxide, Dietary Supplements, Physical therapy, Soybean Proteins, Female, business, Phytotherapy
Abstract

Importance Soy isoflavone supplements are used to treat several chronic diseases, although the data supporting their use are limited. Some data suggest that supplementation with soy isoflavone may be an effective treatment for patients with poor asthma control. Objective To determine whether a soy isoflavone supplement improves asthma control in adolescent and adult patients with poorly controlled disease. Design, Setting, and Participants Multicenter, randomized, double-blind, placebo-controlled trial conducted between May 2010 and August 2012 at 19 adult and pediatric pulmonary and allergy centers in the American Lung Association Asthma Clinical Research Centers network. Three hundred eighty-six adults and children aged 12 years or older with symptomatic asthma while taking a controller medicine and low dietary soy intake were randomized, and 345 (89%) completed spirometry at week 24. Interventions Participants were randomly assigned to receive soy isoflavone supplement containing 100 mg of total isoflavones (n=193) or matching placebo (n=193) in 2 divided doses administered daily for 24 weeks. Main Outcomes and Measures The primary outcome measure was change in forced expiratory volume in the first second (FEV 1 ) at 24 weeks. Secondary outcome measures were symptoms, episodes of poor asthma control, Asthma Control Test score (range, 5-25; higher scores indicate better control), and systemic and airway biomarkers of inflammation. Results Mean changes in prebronchodilator FEV 1 over 24 weeks were 0.03 L (95% CI, −0.01 to 0.08 L) in the placebo group and 0.01 L (95% CI, −0.07 to 0.07 L) in the soy isoflavone group, which were not significantly different ( P = .36). Mean changes in symptom scores on the Asthma Control Test (placebo, 1.98 [95% CI, 1.42-2.54] vs soy isoflavones, 2.20 [95% CI, 1.53-2.87]; positive values indicate a reduction in symptoms), number of episodes of poor asthma control (placebo, 3.3 [95% CI, 2.7-4.1] vs soy isoflavones, 3.0 [95% CI, 2.4-3.7]), and changes in exhaled nitric oxide (placebo, −3.48 ppb [95% CI, −5.99 to −0.97 ppb] vs soy isoflavones, 1.39 ppb [95% CI, −1.73 to 4.51 ppb]) did not significantly improve more with the soy isoflavone supplement than with placebo. Mean plasma genistein level increased from 4.87 ng/mL to 37.67 ng/mL ( P Conclusions and Relevance Among adults and children aged 12 years or older with poorly controlled asthma while taking a controller medication, use of a soy isoflavone supplement, compared with placebo, did not result in improved lung function or clinical outcomes. These findings suggest that this supplement should not be used for patients with poorly controlled asthma. Trial Registration clinicaltrials.gov Identifier:NCT01052116

Published
2015

5. Community Attitudes to People with Disability: Scoping Project

Author

Christiane Purcal, Karen R. Fisher, Denise Thompson, Pooja Sawrikar, and Christopher Deeming

Subjects
Gerontology, medicine.medical_specialty, Economic growth, Public health, Political science, Well-being, medicine, Context (language use), Medical model of disability, Social engagement, Social issues, Mental health, Social policy
Abstract

This paper is an initial step towards building an evidence base on Australian community attitudes to people with disability, on the impact of these attitudes on outcomes for people with disability and on effective policies for improving community attitudes towards them. In this context, ‘outcome’ refers to the experiences of people with disability as measured by social policy indicators within the domains of education, employment, community and social participation, health and wellbeing, housing and access to support services. People with disability and their families and carers have reported the effects of negative attitudes towards disability across all life domains; further evidence of these effects includes the experiences of discrimination reported to the Australian Human Rights Commission and constant investments by governments in efforts to change community attitudes. The need to address attitudes was featured in the reports of the consultations for both the National Disability Strategy and the National Mental Health and Disability Employment Strategy (Deane 2009; DEEWR 2009). FaHCSIA commissioned the SPRC to conduct a scoping project investigating current research on community attitudes towards people with disability.

Published
2012
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7. S-Nitrosoglutathione (GSNO) Catabolic Enzymes In Severe Asthma

Author

Serpil C. Erzurum, Benjamin Gaston, Talissa A. Altes, Douglas Curran-Everett, Nadzeya Marozkina, Eduardo de Lange, Suzy A.A. Comhair, Denise Thompson-Batt, and W. G. Teague

Subjects
chemistry.chemical_classification, S-Nitrosoglutathione, chemistry.chemical_compound, Enzyme, chemistry, Catabolism, business.industry, Severe asthma, Medicine, Pharmacology, business
Published
2011
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8. Post-Diagnosis Support for Children with Autism Spectrum Disorder, Their Families and Carers

Author

Kylie Valentine, Marianne Rajkovic, Brooke Dinning, and Denise Thompson

Subjects
medicine.medical_specialty, Autism spectrum disorder, Perception, media_common.quotation_subject, medicine, Service provider, Psychiatry, Psychology, medicine.disease, Intervention studies, Clinical psychology, media_common
Abstract

Occasional Paper No. 35 consists of two reports on post-diagnosis support for children with Autism Spectrum Disorder. The first report, Post-diagnosis support for children with Autism Spectrum Disorder, their families and carers, by kylie valentine and Marianne Rajkovic, with Brooke Dinning and Denise Thompson, focuses on younger children. The second report, Post-diagnosis support for children with Autism Spectrum Disorder, their families and carers: older children and young people, by Marianne Rajkovic, Denise Thompson and Kylie Valentine, focuses on older children and young people. The reports are based on literature reviews addressing the experiences of diagnosis, treatment and support for families with children who are diagnosed with Autism Spectrum Disorder. They focus on the impact of Autism Spectrum Disorder on families and on their perceptions of the benefits of the treatment received and support models provided, as well as intervention studies and programs that assist transitions from school. The reports are also based on interviews with parents and Autism Spectrum Disorder service providers across Australia.

Published
2011
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9. HLA antigens in Alzheimer's disease

Author

Richard Mayeaux, Nicole Suciu-Foca, Elaine Reed, and Denise Thompson

Subjects
0303 health sciences, business.industry, Immunology, General Medicine, Disease, Human leukocyte antigen, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, HLA Antigens, Genetics, Immunology and Allergy, Medicine, Humans, Dementia, Disease Susceptibility, business, 030217 neurology & neurosurgery, 030304 developmental biology
Published
1983

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