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6 results on '"Daniela Chaparro"'

1. Correlation between disease severity indices and quality of life measurement tools in atopic dermatitis patients

Author

Gloria Sanclemente, Natalia Hernández, Liliana Tamayo, Daniela Chaparro, Ángela López, and Colombian Atopic Dermatitis Research Group

Subjects
dermatitis, atopic, correlation of data, quality of life, patient acuity, Medicine, Arctic medicine. Tropical medicine, RC955-962
Abstract

Introduction. Reports regarding the correlation and effect size of change of the full spectrum of quality of life and disease severity measures applied in-person to patients with atopic dermatitis are scarce. Objectives. To assess quality-of-life with 3 different instruments and to evaluate disease severity indices and to determine their correlation and effect size of change between two measurements. Materials and methods. Patient-level data were obtained through two in-person visits. Sociodemographic information and data related to disease distribution, severity (through the BSA, EASI, SCORAD, POEM, and itching scales), and the impact of atopic dermatitis on quality of life using the DLQI and Skindex-29, and EQ-5D, were assessed. The correlation between change in quality-of-life scores and disease severity scores in addition to the standardized effect size were also evaluated. Results. Only 139 out of 212 patients completed the follow-up visit. BSA highly correlated with SCORAD and EASI, and the lowest correlation was found with POEM. The best correlation of pruritus VAS was found with sleep disturbance. The SCORAD score highly correlated with EASI, and the lowest correlation was found with POEM. The magnitude of the effect at initiation of the study vs follow-up was in average moderate to important. Conclusions. Patients with atopic dermatitis experience a substantial burden on quality of life. Disease activity correlates better with quality-of-life measurements when the disease is less severe after starting therapy. POEM and Skindex-29 seem to be optimal to determine disease severity and quality of life in adults with atopic dermatitis.

Published
2024
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2. Epidemiologic characteristics and burden of psoriasis: A multicenter, cross-sectional study

Author

Gloria Sanclemente, Oscar Mora, Natalia Velez, Elvia Quevedo, Julio Amador, Lina Maria Colmenares, Isabel Cuellar, Silvia Herrera, Laura Daniela Chaparro, Catalina Morales, Arturo Argote, and Laura Charry

Subjects
psoriasis, epidemiology, cross-sectional, multicenter, Medicine, Medicine (General), R5-920
Abstract

Background Although psoriasis burden and treatment have been well characterized in developed countries, there are scarce in-depth epidemiological studies in Latin American countries. Objectives To describe the sociodemographic and clinical features and the economic burden of psoriasis among children and adult patients from Colombia. Methods This cross-sectional study included patients from dermatology private practice offices, health provider institutions and hospitals in seven Colombian cities. We collected data on disease distribution, weight, height, body mass index, waist-hip ratio, disease severity, therapy, personal history of comorbidities, and direct costs. Multiple logistic regression analyses were conducted to assess the associations between severity scales and sociodemographic and clinical variables. Results Two-hundred-three patients (43.8% women, 56.2% men) with an age range between 7 to 89 years old were included. The main subtype was psoriasis vulgaris and mean age of diagnosis was 37.1 years. The most common comorbidities were obesity, hypertension, psoriatic arthritis, dyslipidemia and diabetes. Women had a significant increased odds of presenting with psoriatic arthritis. Body-mass-index and hypertension were significantly associated with a higher psoriasis severity, whereas being female and non-obese was associated with a lower risk. A third of the patients had a family history of psoriasis and sleeping disorders. Forty-one percent of participants either had no income or had an income below 224 US dollars per month and >20% of their income was spent on their disease. Conclusions This study is supported by robust scientific data and contributes to understanding the burden of psoriasis in Latin America. This study adds well-supported data through an in-depth clinical and economical characterization of Colombian children and adult patients with psoriasis and shows the high impact and burden of the disease on patients and their families.

Published
2022
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4. Síndrome linfocutáneo de causa infecciosa: revisión narrativa y enfoque diagnóstico

Author

Alejandra Sandoval, Angela M. Mariño Álvarez, Claudia M. Arenas Soto, and Daniela Chaparro Reyes

Subjects
Anamnesis, medicine.medical_specialty, Nocardia brasiliensis, biology, business.industry, General Medicine, Semiology, biology.organism_classification, medicine.disease, Dermatology, law.invention, Gram staining, Lymphangitis, law, medicine, Etiology, Sporothrix schenckii, business, Mycobacterium marinum
Abstract

Introducción: el síndrome linfocutáneo es una forma clínica muy característica de linfangitis, que se presenta con nódulos inflamatorios subcutáneos que siguen un trayecto. Se han descrito múltiples patologías infecciosas que podrían tener esta presentación clínica y su enfoque diagnóstico es clave para un tratamiento acertado. Métodos: se realizó una búsqueda en PubMed MEDLINE y, posteriormente, una revi­sión narrativa describiendo las diferentes etiologías infecciosas del síndrome linfocutáneo. Resultados: el síndrome linfocutáneo puede tener múltiples causas, dentro de las cuales se encuentran infecciones micóticas, bacterianas, por micobacterias típicas o atípicas, y parásitos, siendo Sporothrix schenckii, Nocardia bra­siliensis, Mycobacterium marinum y Leishmania sp. los agentes más frecuentemente asociados. Para determinar su etiología, es necesario considerar aspectos en la anamnesis (procedencia, ocupación, tiempo de evolución, an­tecedente de trauma), semiología de las lesiones, sintomatología asociada y, en muchos casos, confirmación diag­nóstica con biopsias de piel, cultivo o tinción de Gram, u otros. Su tratamiento debe ser dirigido y, generalmente, debido al compromiso de trayectos linfáticos, se extiende por más tiempo respecto a las infecciones localizadas. Conclusiones: cuando nos enfrentamos a un paciente con hallazgos sugestivos de síndrome linfocutáneo, de­bemos considerar múltiples etiologías infecciosas. Con el fin de hacer más sencillo el enfoque diagnóstico, propo­nemos clasificar los agentes causales en 4 grandes grupos: infecciones micóticas, bacterianas, por micobacterias y parasitarias.

Published
2020
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5. Atopic dermatitis in the COVID-19 era: Results from a web-based survey

Author

Natalia Hernández, Gloria Sanclemente, Liliana Tamayo, Ángela López, Angela Seidel, Natalia Hernandez, Daniela Chaparro, Andrés Cortes, Ángela Seidel, Clara Inés Ortiz, Claudia Arenas, Esperanza Meléndez, Julio Amador, Lina Colmenares, María Claudia Guzmán, María Claudia Torres, Mariela Tavera, Mauricio Torres, Miriam Vargas, Mónica Novoa, Mónica Rivera, Natalia Vélez, Oscar Mora, Oscar Medina, and Paola Cárdenas

Subjects
Pulmonary and Respiratory Medicine, Response rate (survey), Coronavirus disease 2019 (COVID-19), business.industry, media_common.quotation_subject, Immunology, COVID-19, Atopic dermatitis, RC581-607, Pessimism, medicine.disease, Article, Test (assessment), Pandemic, medicine, Immunology and Allergy, Itching, Anxiety, Immunologic diseases. Allergy, medicine.symptom, Survey, business, Demography, media_common
Abstract

Given that the COVID-19 era has changed the behavior of all individuals, and since previous reports about its possible impact on atopic dermatitis (AD) patients remained speculative, in this survey we aimed to explore the real impact of COVID-19 among AD patients. All participants provided verbal consent prior to completing the survey. A 37-question web-based survey with no personal identifiers was sent to 212 previously identified AD patients. Itching, sleep disturbances, SARS-CoV-2, illness cost, economic dependence, monthly income, and monthly investment in AD before and during the pandemic, were all included in the analysis. A response rate of 73.1% was obtained. The mean age of participants was 30 years-old, and 57% were women. Around 75% reported AD worsening, and 59.4% of the patients reported sleep problems. Uncertainty, anxiety, and pessimism were frequent during the pandemic. Only 1.3% tested positive for SARS-CoV-2, and it was only significantly associated with comorbidities (p=0.03; Chi2 Test). A significant difference was found in economic dependence and monthly income when compared between before and during the pandemic. This study provides probably the best possible assessment of the clinical, social, and economic effects of the pandemic on patients with an already proven diagnosis of AD.

Published
2021
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6. Inflammatory myofibroblastic tumor presenting as paraneoplastic pemphigus in a 7-year-old girl

Author

Clara Inés Ortiz, Carlos Olmos, Evelyne Halpert, Armando Rojas, Carolina Rumie, Juan Luis Figueroa, Daniela Chaparro, Juan Javier Lammoglia, and Marcela Galindo

Subjects
Pathology, Paraneoplastic Syndromes, Myopathy, Immunofluorescence, Case Report, Pediatrics, Plasma Cell Granuloma, 030207 dermatology & venereal diseases, 0302 clinical medicine, Azathioprine, 030212 general & internal medicine, Erythema multiforme, Child, skin and connective tissue diseases, Cushing Syndrome, Oxacillin, Medical History, integumentary system, Depression, Acantholysis, Incidence (epidemiology), Pemphigus Vulgaris, Skin Biopsy, Eritema multiforme, Thalidomide, Hospitalization, Priority Journal, Female, Rituximab, Mouth Ulcer, Human, medicine.medical_specialty, Abdominal Inflammatory Myofibroblastic Tumor, pediatrics, paraneoplastic syndromes, pemphigus vulgaris, Dermatology, Colombia, Paraneoplastic Pemphigus, Methylprednisolone, Article, Cataract, 03 medical and health sciences, Enfermedades autoinmunes, medicine, Myofibroblastic Tumor, Autoimmune disease, School Child, business.industry, Pemphigus vulgaris, Autoantibody, Skin Infection, Pénfigo, medicine.disease, Enfermedades, Psychotherapy, Paraneoplastic pemphigus, Prednisone, Skin Defect, business, myofibroblastic tumor
Abstract

Introduction: Paraneoplastic pemphigus is an autoimmune disease associated with an underlying tumor. Several cases have been reported as unusual pemphigus vulgaris, erythema multiforme, or paraneoplastic bullous disease,1 but the incidence of the condition is unknown.2 Response to treatment is generally poor, with significant morbidity and mortality. This condition is clinically characterized by severe mucositis and polymorphic blistering skin eruptions, and histologically by acantholysis, keratinocyte necrosis, and interface dermatitis.3 Immunoprecipitation and immunoblot testing detect autoantibodies against desmosomal polypeptides.4 We describe a case of paraneoplastic pemphigus associated with an abdominal inflammatory myofibroblastic tumor in a 7-year-old girl.

Published
2016

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