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1. Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders

Author

Marconi, R., Grasso, L., Antonini, A., De Gaspari, D., Barone, P., Santangelo, G., Colosimo, C., Meco, G., Avarello, T. P., Bottacchi, E., Cannas, A., Ceravolo, M. G., Ceravolo, R., Cicarelli, G., Gaglio, R. M., Giglia, L., Iemolo, F., Manfredi, M., Nicoletti, A., Pederzoli, M., Petrone, A., Pisani, A., Pontieri, F. E., Quatrale, R., Ramat, S., Scala, R., Volpe, G., Zappulla, S., Bentivoglio, R., Stocchi, F., Trianni, G., Del Dotto, P., Morgante, F., Morgante, L., Fabbrini, G., Benincasa, D., Sensi, M., Braga, M., Capecci, M., Caravona, N., D'Asta, G., De Falco, F. A., Pezzoli, G., Di Giovanni, M., Floris, G., Gallerini, S., Gurgone, G., Frosini, D., Meoni, S., Savica, R., Moschella, V., Pepe, F., Petretta, V., Randisi, M. G., Romeno, M., Picillo, M., Sorbello, V., Tiple, D., Guidubaldi, A., Muoio, R., Toni, V., Logi, C., Bartalini, S., Ulivelli, M., Perini, M., Lanfranchi, S., Griffini, S., Troianiello, B., Baratti, M., Amidei, S., Consoli, D., Iellamo, M., Cuomo, T., Scaglioni, A., Medici, D., Abbruzzese, G., Di Brigida, G., Cocco, G. A., Agnetti, V., Cossu, G., Deriu, M., Abrignani, M., Modica, C., Albani, G., Pradotto, L., Martinelli, P., Scaglione, C., Mucchiut, M., Zanini, S., Pennisi, F., Soliveri, P., Albanese, A., Bartolomei, L., L'Erario, R., Capus, L., Ferigo, L., Marano, R., Nastasi, V., Luciano, R., Maiello, L., Simone, P., Fogli, D., Lopiano, L., Pesare, M., Nordera, G., Pilleri, E., Scaravilli, T., Giaccaglini, E., Alesi, C., Corbetta, T., Sgarbi, S., Rapisarda, A., Rizzoli, S., Zanoli, L., Manfredi, A., Marconi, R, Antonini, A, Barone, P, Colosimo, C, Avarello, Tp, Bottacchi, E, Cannas, A, Ceravolo, Mg, Ceravolo, R, Cicarelli, G, Gaglio, Rm, Giglia, L, Iemolo, F, Manfredi, M, Meco, G, Nicoletti, A, Pederzoli, M, Petrone, A, Pisani, A, Pontieri, Fe, Quatrale, R, Ramat, S, Scala, R, Volpe, G, Zappulla, S, Bentivoglio, Ar, Stocchi, F, Trianni, G, Del Dotto, P, De Gaspari, D, Grasso, L, Morgante, F, Santangelo, Gabriella, Fabbrini, G, Morgante, L, and PRIAMO study, Group

Subjects
Questionnaires, Lung Diseases, Male, Aged, Aged, 80 and over, Attention Deficit Disorder with Hyperactivity, Cardiovascular Diseases, Cognition Disorders, Fatigue, Female, Frontal Lobe, Gastrointestinal Diseases, Humans, Kidney Diseases, Logistic Models, Longitudinal Studies, Middle Aged, Parkinsonian Disorders, Predictive Value of Tests, Skin Diseases, Sleep Wake Disorders, Surveys and Questionnaires, Neuropsychological Tests, 2708, Neurology (clinical), Psychiatry and Mental Health, Neurology, Disease, Logistic regression, Parkinson and cognitive impairment, 80 and over, Verbal fluency test, Neuroradiology, Sleep Disorders, General Medicine, non-motor symptoms, Psychiatry and Mental health, Settore MED/26 - NEUROLOGIA, Frontal lobe, Predictive value of tests, Psychology, medicine.medical_specialty, Dermatology, behavioral disciplines and activities, Internal medicine, medicine, Psychiatry, Surrogate endpoint, Frontal functions, Non-motor symptoms, frontal functions, parkinson and cognitive impairment
Abstract

Using data from the PRIAMO study, we investigated non-motor symptoms (NMS) versus frontal lobe dysfunction in patients with idiopathic Parkinson disease (PD); 808 patients with PD and 118 with atypical parkinsonisms (AP) were consecutively enrolled at 55 Centers in Italy. Twelve categories of NMS were investigated. Cognitive impairment was defined as a Mini-Mental Status Evaluation score ≤ 23.8 and frontal lobe dysfunction as a Frontal Assessment Battery (FAB) score ≤ 3.48. Multivariable logistic regression was used to identify predictor of frontal lobe dysfunction in 524 PD patients, and a generalized linear model was used for each of the six FAB items. Not only the total FAB scores but also the single FAB items were lower in AP versus PD (p ≤ 0.005). Age (OR = 1.05), cognitive impairment (OR = 9.54), lack of cardiovascular symptoms (OR = 3.25), attention or memory problems (OR = 0.59) and treatment with L: -DOPA (OR = 5.58) were predictors of frontal lobe dysfunction. MMSE was negatively associated with all FAB items (β ≤ -0.16) and age with all FAB items but prehension behavior (β ≤ -0.01). Previous use of L: -DOPA was negatively associated with verbal fluency (β = -0.32) possibly acting as surrogate marker of disease duration. Cognitive impairment is a predictor of frontal lobe dysfunction. Among NMS, lack of attention or memory problems were negatively associated with frontal impairment. Further studies are nonetheless needed to better identify the predictors of frontal impairment in PD patients.

Published
2012

2. The relationship between cerebral vascular disease and parkinsonism: The VADO study

Author

Antonini, A., Vitale, C., Barone, P., Cilia, R., Righini, A., Bonuccelli, U., Abbruzzese, G., Ramat, S., Petrone, A., Quatrale, R., Marconi, R., Ceravolo, R., Stefani, A., Lopiano, L., Zappia, M., Capus, L., Morgante, L., Tamma, F., Tinazzi, M., Colosimo, C., Guerra, U. P., Valzania, F., Fagioli, G., Distefano, A., Bagnato, A., Feggi, L., Anna, S., Maria Teresa Rosaria De Cristofaro, Nobili, F., Mazzuca, N., Baldari, S., Eleopra, R., Bestetti, A., Benti, R., Varrone, A., Volterrani, D., Massa, R., Stocchi, F., Schillaci, O., Dore, F., Zibetti, M., Castellano, G., Battista, S. G., and Giorgetti, G.

Subjects
Male, Pathology, Parkinson's disease, Parkinson’s disease, Vascular parkinsonism, Dopamine transporter SPECT imaging, Gastroenterology, Severity of Illness Index, Antiparkinson Agents, Cohort Studies, Levodopa, Basal ganglia, 80 and over, Medicine, Tomography, Aged, 80 and over, Parkinsonism, Parkinson Disease, Magnetic Resonance Imaging, Tomography, Emission-Computed, Single-Photon, Humans, Corpus Striatum, Aged, Cerebrovascular Disorders, Cross-Sectional Studies, Dopamine Plasma Membrane Transport Proteins, Middle Aged, Parkinsonian Disorders, Female, MR Imaging, Neurology, Frontal lobe, Settore MED/26 - Neurologia, medicine.symptom, medicine.drug, MR imaging, medicine.medical_specialty, Internal medicine, Severity of illness, business.industry, Vascular disease, medicine.disease, Dyskinesia, nervous system, Neurology (clinical), Emission-Computed, Geriatrics and Gerontology, business, Single-Photon
Abstract

Background The observation of gait abnormalities, parkinsonism and vascular lesions in elderly patients is often reported as vascular parkinsonism (VP). However the status of striatal dopamine transporter (DAT) and the effects of brain vascular lesions on motor features and levodopa responsiveness are poorly defined. Methods We recorded clinical features, chronic response to levodopa and vascular risk factors in a cross-sectional cohort of consecutive elderly patients with possible Parkinson's disease (PD) or VP recruited in 20 centers in Italy. Results We included a total of 158 patients. Onset of motor symptoms was asymmetric in 93 (59%) and symmetric in 65 patients (41%). Symmetric motor onset was associated with greater disease severity. Chronic levodopa response was positive in 75 (47.8%) and negative in 82 patients (52.2%). A negative response to levodopa was associated with greater frequency of symmetric onset of motor symptoms, worst disease severity, absence of dyskinesia and greater number of vascular risk factors. Frontal lobe showed largest vascular load. Striatal DAT was normal in 48 (30.4%) and abnormal in 110 (69.6%) patients. Patients with normal DAT binding showed higher vascular load at MRI. Significant predictive factors of worst disease severity and negative response to levodopa were hypertension, vascular lesions in basal ganglia/periventricular regions, and normal DAT uptake. Conclusions Multiple cerebral vascular lesions modify clinical presentation and severity in patients with parkinsonism and this is underlined by specific risk factors primarily hypertension. Striatal DAT assessment is helpful in identifying patients where therapy benefit is less likely.

Published
2012

3. Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study

Author

Colosimo, C, Morgante, L, Antonini, A, Barone, P, Avarello, Tp, Bottacchi, E, Cannas, A, Ceravolo, Mg, Ceravolo, R, Cicarelli, G, Gaglio, Rm, Giglia, L, Iemolo, F, Manfredi, M, Meco, G, Nicoletti, A, Pederzoli, M, Petrone, A, Pisani, A, Pontieri, Fe, Quatrale, R, Ramat, S, Scala, R, Volpe, G, Zappulla, S, Bentivoglio, Ar, Stocchi, F, Trianni, G, Del Dotto, P, Simoni, L, Marconi, R, Priamo, Sg, Benincasa, D, Biguzzi, S, Braga, M, Capecci, M, Caravona, N, D'Asta, G, De Falco, Fa, De Gaspari, D, Pezzoli, G, Di Giovanni, M, Floris, G, Gallerini, S, Grasso, L, Gurgone, G, Kiferle, L, Meoni, S, Morgante, F, Savica, R, Moschella, V, Pepe, F, Petretta, V, Randisi, Mg, Romeno, M, Santangelo, G, Ianniciell, M, Sorbello, V, Fabbrini, G, Berardelli, A, Guidubaldi, A, Muoio, R, Toni, V, Logi, C, Ciacci, G, Ulivelli, M, Perini, M, Lanfranchi, S, Griffini, S, Troianiello, B, Baratti, M, Amidei, S, Consoli, D, Iellamo, M, Cuomo, T, Scaglioni, A, Medici, D, Abbruzzese, Giovanni, Di Brigida, G, Cocco, Ga, Agnetti, V, Cossu, G, Deriu, M, Abrignani, M, Modica, C, Albani, G, Milan, E, Martinelli, P, Scaglione, C, Mucchiut, M, Zanini, S, Pennisi, F, Soliveri, P, Albanese, A, Bartolomei, L, L'Erario, R, Capus, L, Ferigo, L, Marano, R, Nastasi, V, Luciano, R, Maiello, L, Simone, P, Fogli, D, Lopiano, L, Pesare, M, Nordera, G, Pilleri, E, Scaravilli, T, Giaccaglini, E, Alesi, C, Corbetta, T, Dumitriu, A, Sgarbi, S, Rapisarda, A, Rizzoli, S, Zanoli, L, Manfredi, A., Colosimo C., Morgante L., Antonini A., Barone P., Avarello T.P., Bpttacchi E., Cannas A., Ceravolo M.G., Ceravolo R., Cicarelli G., Gaglio R.M., Giglia L., Iemolo F., Manfredi M., Meco G., Nicoletti A., Pederzoli M., Petrone A., Pisani A., Pontieri FE., Quatrale r., Ramat S., Scala R., Volpe G., Zappulla S., Bentivoglio A.R., Stocchi F., Trianni G., Del Dotto P., Simoni L., Marconi R., PRIAMO STUDY GROUP [.., Martinelli P., ], Colosimo, C, Morgante, L, Antonini, A, Barone, Paolo, Avarello, Tp, Bottacchi, E, Cannas, A, Ceravolo, Mg, Ceravolo, R, Cicarelli, G, Gaglio, Rm, Giglia, L, Iemolo, F, Manfredi, M, Meco, G, Nicoletti, A, Pederzoli, M, Petrone, A, Pisani, A, Pontieri, Fe, Quatrale, R, Ramat, S, Scala, R, Volpe, G, Zappulla, S, Bentivoglio, Ar, Stocchi, F, Trianni, G, Del Dotto, P, Simoni, L, Marconi, R, and PRIAMO STUDY, G. R. O. U. P.

Subjects
Male, Secondary, Neurology, secondary parkinsonism, parkinson and cognitive impairment, Neurological disorder, PRIAMO STUDY, Orthostatic vital signs, Prevalence, Corticobasal degeneration, Supranuclear Palsy, Longitudinal Studies, Parkinsonism, Cognitive disorder, Parkinson Disease, Neurodegenerative Diseases, Middle Aged, non-motor symptoms, atypical parkinsonism, Italy, Atypical parkinsonism, Non-motor symptoms, Parkinson and cognitive impairment, Secondary parkinsonism, epidemiology, Settore MED/26 - Neurologia, Female, Supranuclear Palsy, Progressive, Lewy Body Disease, medicine.medical_specialty, Humans, Aged, Parkinson Disease, Secondary, Cross-Sectional Studies, Multiple System Atrophy, Parkinsonian Disorders, Atypical parkinsonism, Non-motor symptoms, Parkinson and cognitive impairment, Secondary parkinsonism, Neurology (clinical), Aged, Cross-Sectional Studies, Female, Humans, Italy, epidemiology, Lewy Body Disease, epidemiology, Longitudinal Studies, Male, Middle Aged, Multiple System Atrophy, epidemiology, Neurodegenerative Diseases, epidemiology, Parkinson Disease, epidemiology, Parkinsonian Disorders, epidemiology, Prevalence, Supranuclear Palsy, Progressive, Progressive supranuclear palsy, Internal medicine, mental disorders, medicine, Dementia with Lewy bodies, business.industry, medicine.disease, nervous system diseases, Physical therapy, business, PARKINSONISM
Abstract

The PRIAMO study is a cross-sectional longitudinal observational study aimed at describing epidemiology and evolution of non-motor symptoms (NMS) in patients with different forms of parkinsonism recruited in 55 Italian centres and evaluated over 24 months. In this paper, we are reporting prevalence and clinical characteristics of NMS in patients with atypical and secondary parkinsonism. Out of 1307 consecutive patients with a diagnosis of parkinsonism, 83 patients had vascular parkinsonism (VP), 34 had multiple system atrophy (MSA), 30 had progressive supranuclear palsy (PSP), 14 had dementia with Lewy bodies (DLB) and 11 had corticobasal degeneration (CBD). MSA and DLB had the highest number of NMS domains and symptoms, respectively. Gastrointestinal symptoms, pain, urinary problems and postural instability due to orthostatic hypotension were most frequent in MSA. Sleep disturbances were also common with a prevalence of approximately 70% in all diagnostic groups but CBD (36%). Psychiatric symptoms and attention and memory impairment were frequently observed in all diagnoses but were most prevalent among DLB patients, whereas the prevalence of skin and respiratory disorders was rather low in all forms, ranging between 10 and 30%. Atypical parkinsonism patients also reported a low QoL, with no significant differences among the different forms, whereas PD and VP patients had a better QoL.

Published
2009

4. Anhedonia and cognitive impairment in Parkinson's disease: Italian validation of the Snaith-Hamilton Pleasure Scale and its application in the clinical routine practice during the PRIAMO study

Author

Santangelo, G, Morgante, L, Savica, R, Marconi, R, Grasso, L, Antonini, A, De Gaspari, D, Ottaviani, D, Tiple, D, Simoni, L, Barone, P, Priamo, Sg, Colosimo, C, Benincasa, D, Biguzzi, S, Braga, M, Capecci, M, Caravona, N, De Falco, Fa, Pezzoli, G, Di Giovanni, M, Floris, G, Gallerini, S, Gurgone, G, Kiferle, L, Meoni, S, Moschella, V, Morgante, F, Pepe, F, Petretta, V, Randisi, Mg, Romeno, M, Ianniciello, M, Sciortino, G, Guzzardi, Po, Sorbello, V, Fabbrini, G, Guidubaldi, A, Muoio, R, Toni, V, Ferrari, Po, Logi, C, Ciacci, G, Ulivelli, M, Perini, M, Lanfranchi, S, Griffini, S, Troianiello, B, Baratti, M, Amidei, S, Consoli, D, Iellamo, M, Cuomo, T, Scaglioni, A, Medici, D, Abbruzzese, Giovanni, Di Brigida, G, Cocco, Ga, Agnetti, V, Cossu, G, Deriu, M, Abrignani, M, Modica, C, Albani, G, Milan, E, Martinelli, P, Scaglione, C, Mucchiut, M, Zanini, S, Pennisi, F, Soliveri, P, Albanese, A, Bartolomei, L, L'Erario, R, Capus, L, Ferigo, L, Marano, R, Nastasi, V, Luciano, R, Maiello, L, Simone, P, Fogli, D, Lopiano, L, Pesare, M, Molinette, As, Nordera, G, Pilleri, E, Scaravilli, T, Giaccaglini, E, Alesi, C, Corbetta, T, Dumitriu, A, Ingelheim, B, Sgarbi, S, Rapisarda, A, Rizzoli, S, Zanoli, L, Manfredi, A., Santangelo, Gabriella, Morgante, L, Savica, R, Marconi, R, Grasso, L, Antonini, A, De Gaspari, D, Ottaviani, D, Tiple, D, Simoni, L, Barone, P, PRIAMO Study, Group, Santangelo, G, Barone, Paolo, and PRIAMO Study, G. r. o. u. p.

Subjects
Male, medicine.medical_specialty, Parkinson's disease, media_common.quotation_subject, Multilingualism, Pilot Projects, Test validity, Affect (psychology), behavioral disciplines and activities, Aged, Aged, 80 and over, Cognition Disorders, diagnosis/epidemiology/psychology, Depressive Disorder, Major, diagnosis/epidemiology/psychology, Female, Humans, Italy, epidemiology, Male, Middle Aged, Multilingualism, Parkinson Disease, diagnosis/epidemiology/psychology, Pilot Projects, Psychiatric Status Rating Scales, standards, Reproducibility of Results, Pleasure, medicine, 80 and over, Humans, Psychiatry, Depression (differential diagnoses), media_common, Aged, Aged, 80 and over, Psychiatric Status Rating Scales, Depressive Disorder, Major, Depressive Disorder, Parkinsonism, Anhedonia, Reproducibility of Results, Parkinson Disease, Middle Aged, medicine.disease, Test (assessment), Neurology, Italy, standards, Female, epidemiology, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, Psychology, Cognition Disorders, diagnosis/epidemiology/psychology, Clinical psychology
Abstract

To assess the psychometric properties of the Italian version of the Snaith-Hamilton Pleasure Scale (SHAPS) and to study the relationship between anhedonia, depression and cognitive impairment in patients with Parkinson's disease (PD).The SHAPS (14 items) was translated into Italian and pre-tested in a pilot study. Two items evaluating physical anhedonia related to sexual issues were added. The Italian version of SHAPS was validated in 274 consecutive PD patients, divided into patients with major depression according to DSM-IV criteria (dPD) and patients without depression (nPD), and in healthy subjects. To test the feasibility of the instrument and to determine whether clinical data affect anhedonia, we also administered SHAPS to 1307 patients with different types of parkinsonism.The Italian SHAPS proved to be easy to understand as regards the question and answer modes. Intraclass coefficient for test-retest reliability was 0.65 for the total score. KR index was 0.61. ANOVA of the SHAPS total score revealed that scores were higher in dPD patients than in healthy controls and nPD (p0.05). In the 1307 patients with various types of parkinsonism, the SHAPS data showed that anhedonia was related to age, type of parkinsonism, apathy, depression and cognitive impairment. Anhedonia was correlated with frontal dysfunctions in supranuclear palsy and PD patients (r=-0.682 and -0.264 respectively, p0.05).The Italian version of the SHAPS is a reliable tool with which to assess anhedonia in patients with PD and other forms of parkinsonism.

Published
2009

5. The PRIAMO study: background, methods and recruitment

Author

Antonini, A, Colosimo, C, Marconi, R, Morgante, L, Barone, P, Priamo, Sg, Abbruzzese, Giovanni, Abrignani, M, Agnetti, V, Antonini Pezzoli, A, Avarello, T, Baratti, M, Bartolomei, L, Bentivoglio, A, Bottacchi, E, Bracco, F, Cannas, A, Capus, L, Ceravolo, M, Ceravolo, R, Ciacci, G, Cicarelli, G, Consoli, D, Cossu, G, Cuomo, T, De Pandis, M, Del Dotto, P, Gaglio, R, Giaccaglini, E, Giglia, L, Guidi, M, Iemolo, F, Lopiano, L, Luciano, R, Manfredi, M, Marini, P, Martinelli, P, Mauro, A, Meco, G, Mucchiut, M, Nastasi, G, Nordera, G, Pacchetti, C, Pederzoli, M, Pennisi, F, Perini, M, Petrone, A, Pontieri, F, Pramstaller, P, Quatrale, R, Scaglioni, A, Scala, R, Simone, P, Soliveri, P, Stanzione, P, Stocchi, F, Trianni, G, Troianiello, B, Volpe, G, Zàppia, M, Zappulla, S., Antonini, A, Colosimo, C, Marconi, R, Morgante, L, Barone, Paolo, PRIAMO study, g. r. o. u. p., Antonino A., Colosimo C., Marconi R., Morgante L., Barone P., on behalf of the PRIAMO study group [.., Martinelli P., and ]

Subjects
Male, Sleep Wake Disorders, medicine.medical_specialty, Pediatrics, Cross-sectional study, prevalence, Neurocognitive Disorders, Comorbidity, Dermatology, epidemiology, incidence, parkinsonism, Cohort Studies, Parkinsonian Disorders, Quality of life, Epidemiology, medicine, Humans, Dementia, Longitudinal Studies, Aged, business.industry, MULTICENTRIC STUDY, Patient Selection, Incidence (epidemiology), Parkinsonism, General Medicine, medicine.disease, Epidemiologic Studies, Psychiatry and Mental health, Cross-Sectional Studies, Autonomic Nervous System Diseases, Italy, Epidemiologic Research Design, MOTOR SYMPTOMS, Quality of Life, Physical therapy, Female, Neurology (clinical), PARKINSON, business, Cohort study
Abstract

PRIAMO (PaRkinson And non Motor symptOms) is an epidemiology study aimed to assess the prevalence and incidence of non-motor symptoms (NMS) in patients with parkinsonism. PRIAMO consists of two phases: (1) a transversal assessment of the prevalence of NMS and (2) a longitudinal observation with two follow-up visits at 12 and 24 months to establish the incidence of NMS. A secondary aim of PRIAMO is to study the relationship between NMS and quality of life. Patients with parkinsonism have been evaluated in 59 Neurology Centres widely distributed throughout Italy. PRIAMO has analysed a total of 1307 patients (out of 1325 initially enrolled). We expect that PRIAMO will substantially help to quantify the burden of NMS in patients with parkinsonism.

Published
2008

6. How many parkinsonian patients are suitable candidates for deep brain stimulation of subthalamic nucleus? Results of a questionnaire

Author

Maria Gabriella Ceravolo, Giovanni Savettieri, L. Capus, Angelo Antonini, Elena Moro, Marco D'Amelio, Paolo Barone, Letterio Morgante, Paolo Ragonese, Paolo Girlanda, Francesca Morgante, Ubaldo Bonuccelli, Maria Fiorella Contarino, A. Epifanio, Roberto Marconi, Roberto Ceravolo, MORGANTE L, MORGANTE F, MORO E, EPIFANIO A, GIRLANDA P, RAGONESE P, ANTONINI A, BARONE P, BONUCCELLI U, CONTARINO MF, CAPUS L, CERAVOLO MG, MARCONI R, CERAVOLO R, D'AMELIO M, SAVETTIERI G, Morgante, L, Morgante, F, Moro, E, Epifanio, A, Girlanda, P, Ragonese, P, Antonini, A, Barone, Paolo, Bonuccelli, U, Contarino, Mf, Capus, L, Ceravolo, Mg, Marconi, R, Ceravolo, R, D'Amelio, M, Savettieri, G., and Neurology

Subjects
Adult, Male, medicine.medical_specialty, Parkinson's disease, Movement disorders, Neurology, Deep brain stimulation, Deep Brain Stimulation, medicine.medical_treatment, Parkinson Desease, Deep Brain Stimulation, Audiology, behavioral disciplines and activities, Disease severity, Parkinsonian Disorders, Subthalamic Nucleus, Surveys and Questionnaires, medicine, Humans, Aged, Chi-Square Distribution, business.industry, Patient Selection, Middle Aged, medicine.disease, nervous system diseases, Subthalamic nucleus, surgical procedures, operative, nervous system, CAPSIT, Questionnaire, STN DBS, Female, Aging, Neurology (clinical), Physical therapy, Settore MED/26 - Neurologia, medicine.symptom, Geriatrics and Gerontology, Psychology, business, therapeutics, Neuroscience
Abstract

We used a CAPSIT-based questionnaire to estimate the percentage of parkinsonian patients suitable for subthalamic nucleus (STN) deep brain stimulation (DBS) in a movement disorders clinic. We found that out of 641 consecutive PD patients only 1.6% fulfilled strict STN-DBS criteria. When we applied more flexible criteria, the percentage of eligibility increased to 4.5%. Most patients (60%) were ineligible because they did not satisfy multiple questionnaire items. Items related to disease severity were responsible for the largest number of exclusions. This knowledge will help make decisions on resource allocation in centres wishing to start DBS surgery.

Published
2007

7. The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease

Author

L Grasso, Silvia Ramat, Simone Gallerini, Paolo Barone, G. Di Brigida, D. Fogli, Tommaso Scaravilli, M. Braga, Alessandra Nicoletti, M. Romeno, Paolo Martinelli, G. Gurgone, Cesare Colosimo, E. Pilleri, V. Sorbello, S. Amidei, F. Pennisi, Francesco Iemolo, Giorgio Trianni, Vincenzo Toni, E. Milan, Raffaele Palladino, D. Benincasa, Giovanni Pezzoli, M. G. Randisi, Alfredo Petrone, Arianna Guidubaldi, R. Alfano, Tania P. Avarello, A. Scaglioni, Anna Rita Bentivoglio, C. Modica, L. Ferigo, M. Manfredi, Domenico Consoli, Giuseppe Meco, Giampiero Volpe, S. Griffini, Francesca Morgante, R. Scala, G. Nordera, Angelo Antonini, G. Floris, Roberto Erro, R. Muoio, Salvatore Zappulla, Luigi Bartolomei, Edo Bottacchi, Antonio Pisani, V. Petretta, Giovanni Fabbrini, G. Ciacci, L. Maiello, G. Ceravolo, M. Di Giovanni, V. Nastasi, Rocco Quatrale, D. Tiple, Marcello Deriu, S. Lanfranchi, Marianna Capecci, Alberto Albanese, T. Cuomo, Francesco E. Pontieri, Vincenzo Moschella, G. Sciortino, F. A. De Falco, S. Biguzzi, Leonardo Lopiano, Marina Picillo, C. Alesi, D. De Gaspari, Michele Abrignani, Gabriella Santangelo, Fabrizio Stocchi, R. Luciano, M. Baratti, R. M. Giglia, Cesa Scaglione, B. Troianiello, Giovanni Abbruzzese, M. Mucchiut, F. Pepe, S. Zanini, L. Capus, N. Caravona, Giovanni Cossu, V. Agnetti, G. Albani, L. Kiferle, E. Giaccaglini, Roberto Marconi, M. Iellamo, R. Marano, D. Medici, Monica Ulivelli, G. A. Cocco, M. Perini, P. Del Dotto, Rosa M. Gaglio, Rodolfo Savica, C. Logi, G. Ciccarelli, P. Massimo, M. Pesare, Antonino Cannas, Roberto Ceravolo, P. Simone, Letterio Morgante, P. Soliveri, S. Meoni, Picillo, M., Palladino, R., Erro, R., Alfano, R., Colosimo, C., Marconi, R., Antonini, A., Barone, P., Morgante, L., Benincasa, D., Quatrale, R., Biguzzi, S., Braga, M., Ceravolo, G., Capecci, M., Meco, G., Caravona, N., Scala, R., De Falco, F. A., Pezzoli, G., De Gaspari, D., Bottacchi, E., Di Giovanni, M., Cannas, A., Floris, G., Gallerini, S., Grasso, L., Gaglio, R. M., Gurgone, G., Volpe, G., Zappulla, S., Ceravolo, R., Kiferle, L., Ramat, S., Meoni, S., Pisani, A., Moschella, V., Morgante, F., Savica, R., Pepe, F., Ciccarelli, G., Petretta, V., Giglia, R. M., Randisi, M. G., Iemolo, F., Avarello, T. P., Romeno, M., Santangelo, G., Stocchi, F., Sciortino, G., Sorbello, V., Nicoletti, A., Tiple, D., Fabbrini, G., Bentivoglio, A., Pontieri, F. E., Guidubaldi, A., Muoio, R., Toni, V., Del Dotto, P., Logi, C., Ciacci, G., Ulivelli, M., Perini, M., Lanfranchi, S., Griffini, S., Troianiello, B., Baratti, M., Amidei, S., Consoli, D., Iellamo, M., Cuomo, T., Scaglioni, A., Medici, D., Manfredi, M., Abbruzzese, G., Di Brigida, G., Cocco, G. A., Agnetti, V., Cossu, G., Deriu, M., Abrignani, M., Modica, C., Albani, G., Milan, E., Martinelli, P., Scaglione, C., Mucchiut, M., Zanini, S., Pennisi, F., Soliveri, P., Albanese, A., Massimo, P., Bartolomei, L., Capus, L., Ferigo, L., Marano, R., Nastasi, V., Luciano, R., Maiello, L., Simone, P., Fogli, D., Lopiano, L., Pesare, M., Nordera, G., Pilleri, E., Scaravilli, T., Giaccaglini, E., Alesi, C., Petrone, A., and Trianni, G.

Subjects
Male, Neurology, Parkinson's disease, Constipation, Heterogeneity, Parkinson, Phenotype, Prodromal, Sex, PROGRESSION, Disease, 0302 clinical medicine, Apathy, Neuroradiology, Original Communication, Cognition, Parkinson Disease, 030211 gastroenterology & hepatology, Female, medicine.symptom, NONMOTOR SYMPTOMS, Life Sciences & Biomedicine, PRIAMO study group, Human, medicine.medical_specialty, Clinical Neurology, Prodromal Symptoms, Prodromal Symptom, 03 medical and health sciences, Internal medicine, medicine, Humans, Clinical phenotype, Aged, Science & Technology, Neurology & Neurosurgery, business.industry, 1103 Clinical Sciences, Biomarker, medicine.disease, DYSFUNCTION, Biomarkers, Neurology (clinical), Neurosciences & Neurology, business, 1109 Neurosciences, 030217 neurology & neurosurgery
Abstract

Objectives To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages. Methods A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). Results As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Conclusions Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.

Published
2021

8. Language recovery following subthalamic nucleus stimulation in Parkinson??s disease

Author

Alessandro Melatini, Manuela Gioulis, Antonio Vassallo, L. Capus, Sergio Zanini, Antonio Bava, Zanini, S, Melatini, A, Capus, L, Gioulis, M, Vassallo, A, and Bava, Antonio

Subjects
Male, Parkinson's disease, Deep brain stimulation, medicine.medical_treatment, Central nervous system, Electric Stimulation Therapy, Pilot Projects, Stimulation, Neuropsychological Tests, Central nervous system disease, Subthalamic Nucleus, Basal ganglia, medicine, Humans, Aged, Language, Neurologic Examination, General Neuroscience, Parkinson Disease, Recovery of Function, Middle Aged, medicine.disease, Subthalamic nucleus, medicine.anatomical_structure, Cerebral cortex, Female, Psychology, Neuroscience
Abstract

Neuropsychological consequences of stimulation of the subthalamic nucleus for treatment of drug-resistant Parkinson's disease (PD) have been studied previously. However, no detailed investigations of linguistic function modifications have been carried out. We studied four consecutive patients with PD who underwent chronic bilateral stimulation of the subthalamic nuclei. Neuropsychological and linguistic evaluations were performed before and 2 weeks after surgery. Linguistic abilities were studied also 1 year after surgery with stimulators both off and on. Intraphrasal hesitation pauses, phonemic paraphasias and morpho-syntactic errors were significantly reduced and lexical retrieval improved with stimulation of the subthalamic nuclei. Implicit linguistic phenomena, mainly occurring within basal ganglia circuitry, benefited by recovery of functional equilibrium within basal nuclei and between overall basal ganglia circuitry and cerebral cortex.

Published
2003

9. Acute Akinesia, an unusual complication in Parkinson's Disease: a case report

Author

Marco Simonetto, Luca Zanet, Gilberto Pizzolato, Laura Ferigo, Marino Zorzon, L. Capus, Lucia Antonutti, Simonetto, M, Ferigo, L, Zanet, L, Capus, L, Antonutti, L, Zorzon, Marino, and Pizzolato, Gilberto

Subjects
Male, medicine.medical_specialty, Parkinson's disease, Neurology, Apomorphine, Fever, Drug Resistance, Dermatology, Ondansetron, Antiparkinson Agents, Basal Ganglia Diseases, Medicine, Humans, Basal ganglia disease, Creatine Kinase, Aged, biology, business.industry, Parkinson Disease, General Medicine, Syndrome, medicine.disease, Psychiatry and Mental health, Treatment Outcome, Anesthesia, Acute Disease, Dopamine Agonists, biology.protein, Disease Progression, Creatine kinase, Neurology (clinical), Neurosurgery, Serotonin Antagonists, business, Complication, Respiratory Insufficiency, medicine.drug
Abstract

Acute akinesia (AA) is a rare but serious complication of Parkinson's Disease (PD) 0,3% of all patients with PD). It can be related to infectious condition, surgery, or treatment changes. AA can completely recover or result in some motor deficits, and, in the most severe forms, it may lead to untreatable complications and death. Here we report the case of a 67-year-old man with PD who rapidly developed a severe akinetic state with rise of temperature (39 degrees C) and creatine phosphokinase concentration (up to 5000 mg/dL). After excluding infection diseases and other pathologies, we suspected AA and added apomorphine 50mg/die s.c. and ondansetron 8 mg i.v. The patient responded to treatment and ameliorated in few weeks.

Published
2008

10. Neuropsychological changes after subthalamic nucleus stimulation: a 12 month follow-up in nine patients with Parkinson's disease

Author

Rodolfo M. Antonello, L. Capus, Sandro Zambito Marsala, Giuseppe Cazzato, Tatiana Cattaruzza, Paola Torre, Antonio Bava, Rita Moretti, Moretti, Rita, Torre, P, ANTONELLO R., M, Capus, L, ZAMBITO MARSALA, S, Cattaruzza, T, Cazzato, G, and Bava, Antonio

Subjects
Male, medicine.medical_specialty, dbs-stn, follow-up, language, Deep brain stimulation, Parkinson's disease, medicine.medical_treatment, Electric Stimulation Therapy, Stimulation, Neuropsychological Tests, Audiology, Statistics, Nonparametric, Subthalamic Nucleus, medicine, Humans, Prospective Studies, Effects of sleep deprivation on cognitive performance, Aged, Neuropsychology, Parkinson Disease, Cognition, Middle Aged, medicine.disease, Executive functions, Subthalamic nucleus, Neurology, Female, Neurology (clinical), Geriatrics and Gerontology, Psychology, Neuroscience, Follow-Up Studies
Abstract

Deep brain stimulation of the subthalamic nucleus has been recognized as one of the most promising techniques to decrease ‘off’ motor symptoms and motor fluctuations, allowing a reduction of drug therapy and limiting side effects of drug therapy. However, there is still open debate on the possible consequences of chronic subthalamic stimulation on general cognitive performance. A general amelioration of cognitive performance, in particular of executive functions has been reported but results are not homogeneous. We studied nine patients with Parkinson's Disease for 12 months following surgery for deep stimulation, studying their cognitive performances, paying particular attention to linguistic tests and selective alternating words production. Our results may be consistent with a slowing of cognitive activity, with a reduction of quantitative production, but with an increase in control of linguistic production, which is more precise and definite. We discuss the possible significance of these results, fully aware that only nine patients were involved, and that the potential for generalization is seriously limited, with a particular overview on the frontal-subthalamic pathway, which in our opinion is responsible for the results we observed.

Published
2003

11. Cognitive changes following subthalamic nucleus stimulation in two Patients with Parkinson disease

Author

Antonio Bava, L. Capus, Rodolfo M. Antonello, Giuseppe Cazzato, Manuela Gioulis, Rita Moretti, Paola Torre, Sandro Zambito Marsala, Moretti, Rita, Torre, P, ANTONELLO R., M, Capus, L, Gioulis, M, ZAMBITO MARSALA, S, Cazzato, G, and Bava, Antonio

Subjects
Male, cognition, medicine.medical_specialty, Deep brain stimulation, medicine.medical_treatment, Experimental and Cognitive Psychology, Stimulation, Electric Stimulation Therapy, Disease, dbs-stn, Neuropsychological Tests, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Subthalamic Nucleus, Basal ganglia, medicine, Reaction Time, Humans, 0501 psychology and cognitive sciences, Attention, Effects of sleep deprivation on cognitive performance, Problem Solving, Aged, SUBTHALAMUS, Verbal Behavior, 05 social sciences, Cognition, Parkinson Disease, 030229 sport sciences, Middle Aged, Sensory Systems, Electrodes, Implanted, Subthalamic nucleus, Mental Recall, Neurosurgery, Psychology, Neuroscience, Follow-Up Studies
Abstract

The limits of a drug therapy in severe forms of Parkinson disease have led to refining neurosurgery on the basal ganglia. Deep brain stimulation of the subthalamic nucleus has been recognized as one of the most promising techniques to decrease “off” motor symptoms and motor fluctuations, allowing a reduction of drug therapy and limiting side effects of the drugs. There is still open debate on the possible consequences of chronic subthalamic stimulation in other ways, apart from motor symptoms, of general cognitive performance. We examined and followed two patients with Parkinson disease for 9 mo. after surgery for deep stimulation, studying their cognitive performances. There is a general amelioration of cognitive performances, in particular as far as linguistic capabilities is concerned. We discuss the possible significance of these results, reminding strenuously that only two patients were involved, so the potential for generalization is seriously limited.

Published
2002

12. Chronic bilateral electrical stimulation of the subthalamic nucleus for the treatment of advanced Parkinson's disease

Author

M. V. Sarra, L. Capus, S. Zambito Marsala, Marino Zorzon, A. Melatini, Rita Moretti, Paola Torre, Davide V. Moretti, Manuela Gioulis, Nicola Carraro, Capus, L., Melatini, A., Zorzon, Marino, Torre, P., Carraro, N., Moretti, D., Gioulis, M., Moretti, Rita, Sarra, M. V., and Marsala, S. Z.

Subjects
Male, medicine.medical_specialty, Parkinson's disease, Neurology, Stimulation, Electric Stimulation Therapy, Dermatology, Neuropsychological Tests, Functional Laterality, Neurosurgical Procedures, Antiparkinson Agents, Quality of life, Subthalamic Nucleus, medicine, Humans, In patient, Parkinson’s disease, neurosurgery, therapy, electrical stimulation, Aged, Parkinson Disease, General Medicine, Recovery of Function, Middle Aged, medicine.disease, Surgery, Electrodes, Implanted, Psychiatry and Mental health, Subthalamic nucleus, Treatment Outcome, Anesthesia, Quality of Life, Female, Neurology (clinical), Neurosurgery, Complication, Psychology, Cognition Disorders
Abstract

Preliminary reports in patients with Parkinson's disease (PD) showed that subthalamic nucleus (STN) stimulation was able to reverse parkinsoniam state. Since 1998 we evaluated the safety and the efficacy of STN stimulation in 7 patients affected by advanced PD. All patients were included using CAPIT protocol. Motor functions and quality of life were evaluated, before and after surgery, with UPDRS and PDQ38, respectively. At the 6-month follow-up, the off medication/on stimulation UPDRS motor score improved by 50.6% and the on medication/on stimulation by 20.3%. Motor fluctuations were reduced by 57.2% and dyskinesias by 73.5%. The total D-dopa equivalent daily dose was reduced by 40.7%. PDQ38 ameliorated by 49.9%. We did not observe any perioperatory complication and only mild and tolerable side effects after stimulation.

Published
2001

13. Fixed dystonia unresponsive to pallidal stimulation improved by motor cortex stimulation

Author

Alberto Albanese, Carlo Efisio Marras, Angelo Franzini, Daniela Perani, Valentina Garibotto, Francesco Carella, L. Capus, Luigi Romito, Giovanni Broggi, Romito, Lm, Franzini, A, Perani, DANIELA FELICITA L., Carella, F, Marras, C, Capus, L, Garibotto, V, Broggi, G, and Albanese, A.

Subjects
Dystonia, medicine.medical_specialty, Deep brain stimulation, business.industry, Deep Brain Stimulation, medicine.medical_treatment, Motor Cortex, Neurological disorder, Middle Aged, Globus Pallidus, medicine.disease, Neurosurgical Procedure, Central nervous system disease, medicine.anatomical_structure, Physical medicine and rehabilitation, medicine, Humans, Psychogenic disease, Female, Neurology (clinical), business, Neuroscience, Dystonic disorder, Motor cortex
Abstract

We read with interest the report by Romito et al. about a patient with fixed dystonia who responded to motor cortex stimulation.1 In our view, their conclusions are limited by uncertainties about the diagnosis and shortcomings in the evaluation of the therapeutic response. These aspects are important when an invasive neurosurgical procedure is proposed for consideration in similar cases. The diagnosis of psychogenic dystonia is excluded by the authors with the statement that “nothing indicated somatoform or psychogenic disorder.”1 This diagnosis should be suspected when patients have fixed and painful posturing of the neck or limbs, which renders them unable to carry out basic daily activities.2 Possible, probable, documented, and clinically established categories of certainty can be established by applying Fahn and Williams' criteria.3 Only 10% of the fixed dystonia cohort evaluated prospectively with a standardized neuropsychiatric protocol by Schrag et al. did not meet criteria for psychogenic dystonia.4 Furthermore, the posture exhibited by this patient is similar to …

Published
2007

14. Possible risk factors for primary adult onset dystonia: a case-control investigation by the Italian Movement Disorders Study Group

Author

Alberto Albanese, Giovanni Abbruzzese, Paolo Girlanda, S. Maurri, L Capus, D Acquistapace, Coviello, Lepore, Francesco Carella, Giuseppe Galardi, De Berardinis Mt, Aroldo Rossi, Rocco Liguori, Lucio Santoro, Paolo Livrea, Alfredo Berardelli, G Tognoni, Giovanni Defazio, Laura Bertolasi, Defazio, G, Berardelli, A, Abbruzzese, G, Lepore, V, Coviello, V, Acquistapace, D, Capus, L, Carella, F, De Berardinis, Mt, Galardi, G, Girlanda, P, Maurri, S, Albanese, A, Bertolasi, L, Liguori, R, Rossi, A, Santoro, Lucio, Tognoni, G, Livrea, P., DE BERARDINIS, Teresa, and Santoro, L

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, Movement disorders, Neurological disorder, Blepharospam, Age Distribution, Risk Factors, Surveys and Questionnaires, Tremor, medicine, Humans, Risk factor, Family history, Coma, Aged, Dystonia, Analysis of Variance, business.industry, Parkinsonism, Middle Aged, medicine.disease, Psychiatry and Mental health, Logistic Models, Italy, Case-Control Studies, Papers, Etiology, Physical therapy, Focal dystonia, Wounds and Injuries, Surgery, Female, Neurology (clinical), medicine.symptom, Age of onset, business
Abstract

Objectives—Little is known about the aetiology of idiopathic adult onset dystonia. The Italian Movement Disorders Study Group promoted a case-control study on some hypothetical risk factors including past medical events, life events, life habits, occupational hazards, and family hystory of dystonia, parkinsonism, and tremor. Methods—Cases aVected by idiopathic adult onset dystonia (age at symptom onset >20 years, duration of disease >one year and

Published
1998

15. Trigeminal neuralgia due to contralateral meningioma of the posterior cranial fossa

Author

L. Capus, E. Biasutti, G. Masè, B Vitrani, Marino Zorzon, Giuseppe Cazzato, Mase, G, Zorzon, Marino, Capus, L, Biasutti, E, Vitrani, B, and Cazzato, G.

Subjects
medicine.medical_specialty, Neuromuscular disease, business.industry, Cranial nerves, Neurooncology, medicine.disease, Hydrocephalus, Surgery, Meningioma, Psychiatry and Mental health, medicine.anatomical_structure, Posterior cranial fossa, Surgical oncology, Trigeminal neuralgia, medicine, Neurology (clinical), business, Research Article
Published
1994

16. Effects on cognitive abilities following subthalamic nucleus stimulation in Parkinson's disease

Author

Sandro Zambito Marsala, Giuseppe Cazzato, Rodolfo M. Antonello, Paola Torre, Rita Moretti, L. Capus, Manuela Gioulis, Antonio Bava, Moretti, Rita, Torre, P, ANTONELLO R., M, Capus, L, Gioulis, M, MARSALA S., Z, Cazzato, G, and Bava, Antonio

Subjects
Parkinson's disease, business.industry, Electric Stimulation Therapy, Parkinson Disease, Cognition, dbs-stn, medicine.disease, stimulation, electric, Neurology, Subthalamic Nucleus, Humans, pd, Medicine, Neurology (clinical), business, Neuroscience, Subthalamic nucleus stimulation, Cognitive psychology
Published
2001

17. Peculiar aspects of reading and writing performances in patients with olivopontocerebellar atrophy

Author

Manuela Gioulis, Rodolfo M. Antonello, Ma Ja Ukmar, Rita Moretti, Paola Torre, Antonio Bava, Giuseppe Cazzato, Nicola Carraro, Sandro Zambito-Marsala, L. Capus, Moretti, Rita, Torre, P, ANTONELLO R., M, Carraro, N, ZAMBITO MARSALA, S, Ukmar, M, Capus, L, Gioulis, M, Cazzato, G, and Bava, Antonio

Subjects
Male, Cerebellum, medicine.medical_specialty, cerebellum, media_common.quotation_subject, Experimental and Cognitive Psychology, Audiology, Neuropsychological Tests, 050105 experimental psychology, opca, Dyslexia, 03 medical and health sciences, 0302 clinical medicine, Olivopontocerebellar atrophy, reading, Reading (process), medicine, Humans, 0501 psychology and cognitive sciences, In patient, Agraphia, media_common, Aged, Neurologic Examination, 05 social sciences, Cognition, writing, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Sensory Systems, 030227 psychiatry, medicine.anatomical_structure, Mood disorders, Cerebral cortex, Olivopontocerebellar Atrophies, Female, Psychomotor Disorders, Psychology, Reticular activating system, Cognitive psychology, Brain Stem
Abstract

Olivopontocerebellar atrophy (OPCA) is a still debated condition, of which motor disruption is the most common feature. A high incidence of associated mood disorders may exist, but there are few studies on concomitant cognitive impairment. Our aim was to assess whether there is reading and writing disruption in olivopontocerebellar atrophy (OPCA). 6 patients were administered different reading and writing tasks. Scores were then compared to those obtained by healthy volunteers. There was an evident impairment in reading and writing execution in out patients compared to those of the control group. On the contrary, no difference could be found in abstraction, problem-solving, and memory tasks. We discuss the results, debating the role of the cerebellum in the conscious process of cognition or in ocular movement control (necessary for reading and writing fluidity and effective execution) and in the dynamic activation of all the cerebral cortex mediated by the diffuse projection to the reticular system.

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