24 results on '"Burkhardt, Harald"'
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2. Feuer unter der Haut
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Meier, Florian, Ferdinand, Samantha, Braner, Axel, and Burkhardt, Harald Louis
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Vorgeschichte: Eine 53-jährige Syrerin präsentierte sich erstmalig Ende 2018 in einer chirurgischen Notaufnahme bei rasch zunehmender, schmerzhafter Weichteilschwellung mit Blasenbildung und Knistern der Haut beider Unterarme. Es erfolgte eine IV-Antibiose, sowie chirurgische Sanierung mit[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2021
3. Noli me tangere
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Bel, Ann Christin, Ferdinand, Samantha, Braner, Axel, and Burkhardt, Harald Louis
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Vorgeschichte: 28-jährige deutsche Patientin mit Morbus Behcet (Erstdiagnose 2017). Vorbefundlich Z.n. gastrointestinale Blutungen (Forrest Ia) aufgrund gastraler und duodenaler ulceröser Läsionen. Extern erfolgte Diagnosesicherung einer Zöliakie. Leitsymptom bei Krankheitsmanifestation:[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
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- 2020
- Full Text
- View/download PDF
4. Late onset 'Kinderkrankheit'?
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Braner, Axel, Drott, Ulrich, Meier, Florian, Mojtahed Poor, Sorwe, Ferdinand, Samantha, and Burkhardt, Harald
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Vorgeschichte: Übernahme einer 69-jährigen Patientin auf die infektiologische Station der Universitätsklinik Frankfurt aus einem peripheren Krankenhaus der Regelversorgung. Seit 2 Monaten Fieberschübe bis 40°C mit Polyserositis. Außer deutlich erhöhten Entzündungswerten[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
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- 2020
5. Was frisst mich da auf?!
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Ferdinand, Samantha, Zanganas, Georgios, Bel, Ann Christin, Braner, Axel, and Burkhardt, Harald Louis
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Vorgeschichte: Stationäre Aufnahme einer 44-jährigen, bis dato gesunden Patientin (Risikofaktoren: Nikotinabusus und Adipositas), initial in der Infektiologie, zur Abklärung stark schmerzender Hauteffloreszenzen nach einem Heimaturlaub in Rumänien. Keine bekannte Atopie, keine Vormedikation.[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
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- 2020
6. Evaluation of different fluorescence-optical imaging (FOI) assessment methods to differentiate clinical psoriatic arthritis from psoriasis
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Haan, Luis, Henkemeier, Ulf, Foldenauer, Ann Christina, Burkhardt, Harald, Behrens, Frank, and Köhm, Michaela
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Introduction: Fluorescence-optical imaging (FOI) is an indocyanine green (ICG) tailored method to detect microvascular changes in the hands using ICG kinetics over 360 sec. Different methods for the assessment of FOI are available. The aim of this study is to evaluate to what extent these methods can[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
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- 2020
7. A prospective, multicentre study to determine the incidence of rheumatoid arthritis in anti-CPP positive and anti-CPP negative patients who exhibit a new onset of musculoskeletal symptoms
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Dauth, Stephanie, Köhm, Michaela, Oberwahrenbrock, Timm, Henkemeier, Ulf, Roßmanith, Tanja, Mergenthal, Karola, Petersen, Juliana J., Burkhardt, Harald, and Behrens, Frank
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musculoskeletal diseases ,ddc: 610 ,610 Medical sciences ,Medicine ,skin and connective tissue diseases - Abstract
Introduction: Strategies for the early detection and diagnosis of Rheumatoid Arthritis (RA) are of high importance as prompt treatment improves clinical and structural outcome. Autoantibodies against cyclic citrullinated proteins (anti-CCP) have been associated with RA-development. Non-specific musculoskeletal[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
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- 2020
8. Innovative Imaging Technique for Visualization of Vascularization and Established Methods for Detection of Musculoskeletal Inflammation in Psoriasis Patients
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Köhm, Michaela, Zerweck, Lukas, Ngyuen, Phuong-Ha, Burkhardt, Harald, Behrens, Frank, and Publica
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psoriatic arthritis ,Medicine ,imaging ,ddc:610 ,Review ,psoriasis ,General Medicine ,early detection ,musculoskeletal inflammation - Abstract
Psoriasis (PsO) is one of the common chronic inflammatory skin diseases. Approximately 3% of the European Caucasian population is affected. Psoriatic arthritis (PsA) is a chronic immune-mediated disease associated with PsO characterized by distinct musculoskeletal inflammation. Due to its heterogeneous clinical manifestations (e.g., oligo- or polyarthritis, enthesitis, dactylitis, and axial inflammation), early diagnosis of PsA is often difficult and delayed. Approximately 30% of PsO patients will develop PsA. The responsible triggers for the transition from PsO only to PsA are currently unclear, and the impacts of different factors (e.g., genetic, environmental) on disease development are currently discussed. There is a high medical need, recently unmet, to specifically detect those patients with an increased risk for the development of clinically evident PsA early to initiate sufficient treatment to inhibit disease progression and avoid structural damage and loss of function or even intercept disease development. Increased neoangiogenesis and enthesial inflammation are hypothesized to be early pathological findings in PsO patients with PsA development. Different disease states describe the transition from PsO to PsA. Two of those phases are of value for early detection of PsA at-risk patients to prevent later development of PsA as changes in biomarker profiles are detectable: the subclinical phase (soluble and imaging biomarkers detectable, no clinical symptoms) and the prodromal phase (imaging biomarkers detectable, unspecific musculoskeletal symptoms such as arthralgia and fatigue). To target the unmet need for early detection of this at-risk population and to identify the subgroup of patients who will transition from PsO to PsA, imaging plays an important role in characterizing patients precisely. Imaging techniques such as ultrasound (US), magnetic resonance imaging (MRI), and computerized tomography (CT) are advanced techniques to detect sensitively inflammatory changes or changes in bone structure. With the use of these techniques, anatomic structures involved in inflammatory processes can be identified. These techniques are complemented by fluorescence optical imaging as a sensitive method for detection of changes in vascularization, especially in longitudinal measures. Moreover, high-resolution peripheral quantitative CT (HR-pQCT) and dynamic contrast-enhanced MRI (DCE-MRI) may give the advantage to identify PsA-related early characteristics in PsO patients reflecting transition phases of the disease.
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- 2020
- Full Text
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9. Patientencharakteristika und Inzidenz früher entzündlicher Veränderungen in Patienten mit neuem Auftreten unspezifischer muskuloskelettaler Beschwerden und positivem Nachweis von antiCCP-Antikörpern im Schnelltest - die PANORA Studie
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Köhm, Michaela, Henkemeier, Ulf, Rossmanith, Tanja, Mergenthal, Karola, Petersen, Juliana J., Burkhardt, Harald Louis, and Behrens, Frank
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Die Rheumatoide Arthritis (RA) ist eine chronisch-entzündliche Gelenkerkrankung mit einer Prävalenz von etwa 1% in Nordeuropa. Die Bildung von Autoantikörpern gegen anti-CCP ist assoziiert mit dem RA-Auftreten. Neu auftretende unspezifische muskuloskelettale (usMSK) Beschwerden[zum vollständigen Text gelangen Sie über die oben angegebene URL], 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2019
10. Charakterisierung von Psoriasis-Patienten mit subklinischen Zeichen der muskuloskelettalen Entzündung ermittelt durch Fluoreszenz-optische Bildgebung und Überprüfung des Befundes mittels MRT - Analyse der prospektiven multizentrischen XCITING Studie
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Köhm, Michaela, Ohrndorf, Sarah, Rossmanith, Tanja, Langer, Hans-Eckhard, Burmester, Gerd-Rüdiger, Backhaus, Marina, Wassenberg, Siegfried, Köhler, Benjamin, Burkhardt, Harald Louis, and Behrens, Frank
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Die Psoriasis vulgaris (PsO) ist eine der häufigsten chronisch-entzündlichen Hauterkrankungen in Europa. In etwa 30% der Patienten tritt im Verlauf eine Psoriasis Arthritis (PsA) auf. In PsA-Frühformen können Änderungen der synovialen Vaskularisierung festgestellt[zum vollständigen Text gelangen Sie über die oben angegebene URL], 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2019
11. Einfluss der Kombinationstherapie von Rituximab und Lefluonmid auf Patient-Reported Outcomes und Funktion in Patienten mit Rheumatoider Arthritis: Ergebnisse einer multizentrischen, randomisierten, Placebo-kontrollierten Investigator initiierten Studie (AMARA-Study)
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Köhm, Michaela, Rossmanith, Tanja, Dauth, Stephanie, Alten, Rieke H.-E., Aringer, Martin, Backhaus, Marina, Burmester, Gerd-Rüdiger, Feist, Eugen, Kellner, Herbert, Krüger, Klaus, Müller-Ladner, Ulf, Rubbert-Roth, Andrea, Tony, Hans-Peter, Wassenberg, Siegfried, Burkhardt, Harald Louis, and Behrens, Frank
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Biologikatherapien wie Rituximab (RTX) stellen eine wirksame Therapieoption in der Behandlung der Rheumatoiden Arthritis (RA) dar. Zumeist sind hier ausschließlich Kombinationstherapien mit Methotrexat (MTX) zugelassen, obwohl bei Kontraindikationen oder Unverträglichkeiten andere[zum vollständigen Text gelangen Sie über die oben angegebene URL], 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2019
12. Detektion von klinisch manifester Arthritis mittels klinischer Untersuchung und subklinischen Zeichen von Entzündung mittels Ultraschall und Fluoreszenz-optischer Bildgebung in Psoriasis-Patienten mit Risikokonstellation für das Auftreten einer Arthritis - Ergebnisse der prospektiven multizentrischen XCITING Studie
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Köhm, Michaela, Rossmanith, Tanja, Dauth, Stephanie, Langer, Hans-Eckhard, Backhaus, Marina, Burmester, Gerd-Rüdiger, Ohrndorf, Sarah, Wassenberg, Siegfried, Köhler, Benjamin, Burkhardt, Harald Louis, and Behrens, Frank
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ddc: 610 ,610 Medical sciences ,Medicine ,urologic and male genital diseases - Abstract
Einleitung: Psoriasis vulgaris (PsO) ist die häufigste chronisch-entzündliche Hauterkrankung in Europa. In etwa 30% der PsO-Patienten tritt im Verlauf eine Psoriasis Arthritis (PsA) auf. Biomarker für die PsA-Frühdiagnostik fehlen. In frühen Formen der PsA können Änderungen[zum vollständigen Text gelangen Sie über die oben angegebene URL], 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2019
13. Phenotypes determined by cluster analysis and their survival in the prospective European Scleroderma Trials and Research cohort of patients with systemic sclerosis
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Sobanski, Vincent, Giovannelli, Jonathan, Allanore, Yannick, Riemekasten, Gabriela, Airo, Paolo, Vettori, Serena, Cozzi, Franco, Distler, Oliver, Matucci-Cerinic, Marco, Denton, Christopher, Launay, David, Hachulla, Eric, Cerinic, Marco Matucci, Guiducci, Serena, Walker, Ulrich, Kyburz, Diego, Lapadula, Giovanni, Iannone, Florenzo, Maurer, Britta, Jordan, Suzana, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Cutolo, Maurizio, Sulli, Alberto, Valentini, Gabriele, Cuomo, Giovanna, Siegert, Elise, Rednic, Simona, Nicoara, Ileana, Kahan, Andre, Vlachoyiannopoulos, Panayiotis, Montecucco, Carlo, Caporali, Roberto, Stork, Jiri, Inanc, Murat, Carreira, Patricia E, Novak, Srdan, Czirjak, Laszlo, Varju, Cecilia, Chizzolini, Carlo, Kucharz, Eugene J, Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Wu, Chen, Marjanovic, Zora, Faivre, Helene, Hij, Darin, Dhamadi, Roza, Hesselstrand, Roger, Wollheim, Frank, Wuttge, Dirk M, Andreasson, Kristofer, Martinovic, Duska, Balbir-Gurman, Alexandra, Braun-Moscovici, Yolanda, Trotta, Francesco, Lo Monaco, Andrea, Hunzelmann, Nicolas, Pellerito, Raffaele, Bambara, Lisa Maria, Caramaschi, Paola, Morovic-Vergles, Jadranka, Black, Carol, Damjanov, Nemanja, Henes, Joerg, Ortiz Santamaria, Vera, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthias, Hasler, Paul, Burkhardt, Harald, Himsel, Andrea, Bajocchi, Gianluigi, Nuova, Arcispedale Santa Maria, Salvador, Maria Joao, Pereira Da Silva, Jose Antonio, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Marasini, Bianca, Tikly, Mohammed, Ananieva, Lidia P, Denisov, Lev N, Mueller-Ladner, Ulf, Frerix, Marc, Tarner, Ingo, Scorza, Raffaella, Puppo, Francesco, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szucs, Gabriella, Szamosi, Szilvia, Zea Mendoza, Antonio, de la Puente, Carlos, Sifuentes Giraldo, Walter Alberto, Midtvedt, Oyvind, Reiseter, Silje, Garen, Torhild, Valesini, Guido, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Wigley, Fredrick M, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Soare, Alina, Gorga, Marilena, Bojinca, Mihai, Mihai, Carina, Milicescu, Mihaela, Sunderkoetter, Cord, Kuhn, Annegret, Sandorfi, Nora, Schett, Georg, Distler, Joerg HW, Beyer, Christian, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Smith, Vanessa, Cantatore, Francesco Paolo, Corrado, Ada, Ullman, Susanne, Iversen, Line, von Muehlen, Carlos Alberto, Bohn, Jussara Marilu, Lonzetti, Lilian Scussel, Pozzi, Maria Rosa, Eyerich, Kilian, Hein, Ruediger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Houssiau, Frederic A, Jose Alegre-Sancho, Juan, Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Guenther, Claudia, Westhovens, Rene, de Langhe, Ellen, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Uprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Radominski, Sebastiao Cezar, Mueller, Carolina de Souza, Azevedo, Valderilio Feijo, Jimenez, Sergio, Busquets, Joanna, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Popa, Sergei, Zenone, Thierry, Pileckyte, Margarita, Stebbings, Simon, Highton, John, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D, Yoshinari, Natalino H, Marangoni, Roberta G, Martin, Patricia, Fuocco, Luiza, Stamp, Lisa, Chapman, Peter, O'Donnell, John, Solanki, Kamal, Doube, Alan, Veale, Douglas, O'Rourke, Marie, Loyo, Esthela, Li, Mengtao, Mohamed, Walid Ahmed Abdel Atty, Rosato, Edoardo, Amoroso, Antonio, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Chirieac, Rodica, Ancuta, Codrina, Furst, Daniel E, Villiger, Peter, Adler, Sabine, van Laar, Jacob, Kayser, Cristiane, Eduardo, Andrade Luis C, Fathi, Nihal, Hassanien, Manal, de la Pena Lefebvre, Paloma Garcia, Rodriguez Rubio, Silvia, Valero Exposito, Marta, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Helene, Litinsky, Ira, Emery, Paul, Buch, Maya, Del Galdo, Francesco, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Saketkoo, Lesley Ann, Lasky, Joseph A, Kerzberg, Eduardo, Montoya, Fabiana, Cosentino, Vanesa, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Rosner, Itzhak, Rozenbaum, Michael, Slobodin, Gleb, Boulman, Nina, Rimar, Doron, Couto, Maura, Spertini, Francois, Ribi, Camillo, Buss, Guillaume, Kahl, Sarah, Hsu, Vivien M, Chen, Fei, McCloskey, Deborah, Malveaux, Halina, Pasquali, Jean Louis, Martin, Thierry, Gorse, Audrey, Guffroy, Aurelien, Poindron, Vincent, EUSTAR Collaborators, Guiducci, S., Walker, U., Kyburz, D., Lapadula, G., Iannone, F., Maurer, B., Jordan, S., Becvar, R., Sierakowsky, S., Kowal Bielecka, O., Cutolo, M., Sulli, A., Valentini, G., Cuomo, G., Siegert, E., Rednic, S., Nicoara, I., Kahan, A., Vlachoyiannopoulos, P., Montecucco, C., Caporali, R., Stork, J., Inanc, M., Carreira, P.E., Novak, S., Czirják, L., Varju, C., Chizzolini, C., Kucharz, E.J., Kotulska, A., Kopec-Medrek, M., Widuchowska, M., Rozman, B., Mallia, C., Coleiro, B., Gabrielli, A., Farge, D., Wu, C., Marjanovic, Z., Faivre, H., Hij, D., Dhamadi, R., Airò, P., Hesselstrand, R., Wollheim, F., Wuttge, D.M., Andréasson, K., Martinovic, D., Balbir-Gurman, A., Braun-Moscovici, Y., Trotta, F., Lo Monaco, A., Hunzelmann, N., Pellerito, R., Mauriziano, O., Maria Bambara, L., Caramaschi, P., Morovic-Vergles, J., Black, C., Damjanov, N., Henes, J., Ortiz Santamaria, V., Heitmann, S., Krasowska, D., Seidel, M., Hasler, P., Burkhardt, H., Himsel, A., Bajocchi, G., Maria Nuova, A.S., João Salvador, M., Pereira Da Silva, J.A., Stamenkovic, B., Stankovic, A., Francesco Selmi, C., De Santis, M., Marasini, B., Tikly, M., Ananieva, L.P., Denisov, L.N., Müller-Ladner, U., Frerix, M., Tarner, I., Scorza, R., Puppo, F., Engelhart, M., Strauss, G., Nielsen, H., Damgaard, K., Szücs, G., Szamosi, S., Zea Mendoza, A., de la Puente, C., Sifuentes Giraldo, W.A., Midtvedt, Ø., Reiseter, S., Garen, T., Valesini, G., Riccieri, V., Maria Ionescu, R., Opris, D., Groseanu, L., Wigley, F.M., Sfrent Cornateanu, R., Ionitescu, R., Maria Gherghe, A., Soare, A., Gorga, M., Bojinca, M., Mihai, C., Milicescu, M., Sunderkötter, C., Kuhn, A., Sandorfi, N., Schett, G., Distler, J.H., Beyer, C., Meroni, P., Ingegnoli, F., Mouthon, L., De Keyser, F., Smith, V., Paolo Cantatore, F., Corrado, A., Ullman, S., Iversen, L., Alberto von Mühlen, C., Marilu Bohn, J., Scussel Lonzetti, L., Rosa Pozzi, M., Eyerich, K., Hein, R., Knott, E., Wiland, P., Szmyrka-Kaczmarek, M., Sokolik, R., Morgiel, E., Madej, M., Houssiau, F.A., Jose Alegre-Sancho, J., Krummel-Lorenz, B., Saar, P., Aringer, M., Günther, C., Westhovens, R., de Langhe, E., Lenaerts, J., Anic, B., Baresic, M., Mayer, M., Üprus, M., Otsa, K., Yavuz, S., Granel, B., Cezar Radominski, S., de Souza Müller, C., Azevedo, V.F., Jimenez, S., Busquets, J., Agachi, S., Groppa, L., Chiaburu, L., Russu, E., Popa, S., Zenone, T., Pileckyte, M., Stebbings, S., Highton, J., Mathieu, A., Vacca, A., Sampaio-Barros, P.D., Yoshinari, N.H., Marangoni, R.G., Martin, P., Fuocco, L., Stamp, L., Chapman, P., O'Donnell, J., Solanki, K., Doube, A., Veale, D., O'Rourke, M., Loyo, E., Li, M., Abdel Atty Mohamed, W.A., Rosato, E., Amoroso, A., Gigante, A., Oksel, F., Yargucu, F., Tanaseanu, C.M., Popescu, M., Dumitrascu, A., Tiglea, I., Foti, R., Chirieac, R., Ancuta, C., Furst, D.E., Villiger, P., Adler, S., van Laar, J., Kayser, C., Eduardo C, A.L., Fathi, N., Hassanien, M., de la Peña Lefebvre, P.G., Rodriguez Rubio, S., Valero Exposito, M., Sibilia, J., Chatelus, E., Gottenberg, J.E., Chifflot, H., Litinsky, I., Emery, P., Buch, M., Del Galdo, F., Venalis, A., Butrimiene, I., Venalis, P., Rugiene, R., Karpec, D., Ann Saketkoo, L., Lasky, J.A., Kerzberg, E., Montoya, F., Cosentino, V., Limonta, M., Luca Brucato, A., Lupi, E., Rosner, I., Rozenbaum, M., Slobodin, G., Boulman, N., Rimar, D., Couto, M., Spertini, F., Ribi, C., Buss, G., Kahl, S., Hsu, V.M., Chen, F., McCloskey, D., Malveaux, H., Louis Pasquali, J., Martin, T., Gorse, A., Guffroy, A., Poindron, V., and Chizzolini, Carlo
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0301 basic medicine ,Male ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences ,Databases, Factual ,systemic sclerosis ,SUBSETS ,Disease ,Severity of Illness Index ,Scleroderma ,DISEASE ,0302 clinical medicine ,Medicine and Health Sciences ,Immunology and Allergy ,Cluster Analysis ,CRITERIA ,Prospective Studies ,Prospective cohort study ,skin and connective tissue diseases ,integumentary system ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti ,Adult ,Aged ,Autoantibodies/blood ,Europe/epidemiology ,Female ,Humans ,Middle Aged ,Phenotype ,Prognosis ,Scleroderma, Diffuse/blood ,Scleroderma, Diffuse/epidemiology ,Scleroderma, Diffuse/pathology ,Scleroderma, Limited/blood ,Scleroderma, Limited/epidemiology ,Scleroderma, Limited/pathology ,Scleroderma, Systemic/blood ,Scleroderma, Systemic/epidemiology ,Scleroderma, Systemic/pathology ,Connective tissue disease ,ddc ,Europe ,MANIFESTATIONS ,Cohort ,Life Sciences & Biomedicine ,medicine.medical_specialty ,Immunology ,PROFILE ,CLASSIFICATION ,03 medical and health sciences ,Rheumatology ,Scleroderma, Limited ,Internal medicine ,Severity of illness ,medicine ,Autoantibodies ,030203 arthritis & rheumatology ,Science & Technology ,Scleroderma, Systemic ,business.industry ,Autoantibody ,Systemic sclerosis (SSc) ,medicine.disease ,030104 developmental biology ,Scleroderma, Diffuse ,business - Abstract
OBJECTIVE: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that is typically subdivided into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) depending on the extent of skin involvement. This subclassification may not capture the entire variability of clinical phenotypes. The European Scleroderma Trials and Research (EUSTAR) database includes data on a prospective cohort of SSc patients from 122 European referral centers. This study was undertaken to perform a cluster analysis of EUSTAR data to distinguish and characterize homogeneous phenotypes without any a priori assumptions, and to examine survival among the clusters obtained. METHODS: A total of 11,318 patients were registered in the EUSTAR database, and 6,927 were included in the study. Twenty-four clinical and serologic variables were used for clustering. RESULTS: Clustering analyses provided a first delineation of 2 clusters showing moderate stability. In an exploratory attempt, we further characterized 6 homogeneous groups that differed with regard to their clinical features, autoantibody profile, and mortality. Some groups resembled usual dcSSc or lcSSc prototypes, but others exhibited unique features, such as a majority of lcSSc patients with a high rate of visceral damage and antitopoisomerase antibodies. Prognosis varied among groups and the presence of organ damage markedly impacted survival regardless of cutaneous involvement. CONCLUSION: Our findings suggest that restricting subsets of SSc patients to only those based on cutaneous involvement may not capture the complete heterogeneity of the disease. Organ damage and antibody profile should be taken into consideration when individuating homogeneous groups of patients with a distinct prognosis. ispartof: ARTHRITIS & RHEUMATOLOGY vol:71 issue:9 pages:1553-1570 ispartof: location:United States status: published
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- 2019
14. Digital ulcers predict a worse disease course in patients with systemic sclerosis
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Mihai, Carina, Landewé, Robert, Van Der Heijde, Désirée, Walker, Ulrich A., Constantin, Paul I., Gherghe, Ana Maria, Ionescu, Ruxandra, Rednic, Simona, Allanore, Yannick, Avouac, Jéroˆme, Czirják, László, Hachulla, Eric, Riemekasten, Gabriela, Cozzi, Franco, Airò, Paolo, Cutolo, Maurizio, Mueller Ladner, Ulf, Matucci Cerinic, Marco, Launay, David, Dobrota, Rucsandra, Sfrent Cornateanu, Roxana, Zingarelli, Stefania, Pigatto, Erika, Cuomo, Giovanna, Caramaschi, Paola, Ananieva, Lidia, Ullman, Susanne, Iversen, Line, Gurman, Alexandra Balbir, Braun Moscovici, Yolanda, Carreira, Patricia E., Joven, Beatriz E., Minier, Tünde, Guiducci, Serena, Bellando Randone, Silvia, Pellerito, Raffaele, Hunzelmann, Nicolas, Tarner, Ingo H., Radominski, Sebastião Cezar, De Souza Müller, Carolina, Iannone, Florenzo, Henes, Jörg, Bancel, Dominique Farge, Damjanov, Nemanja, Ostojic, Predrag, Pozzi, Maria Rosa, Hesselstrand, Roger, Denton, Christopher, Krasowska, Dorota, Tikly, Mohammed, Riccieri, Valeria, Cantatore, Francesco Paolo, Corrado, Ada, Da Silva, José Antonio Pereira, Salvador, Maria João, Tyndall, Alan, Gabrielli, Armando, Distler, Oliver, Jordan, Suzan, Heitmann, Stefan, Burkhardt, Harald, Himsel, Andrea, Rozman, Blaz, Smith, Vanessa, Keyser, Filip De, Kalitena, Dusanka Martinovic, Radic, Mislav, Filipescu, Ileana, Petcu, Ana, Vlachoyiannopoulos, Panayiotis, Kucharz, Eugene J., Widuchowska, Malgorzata, Kopec Medrek, Magdalena, Kotulska, Anna, Szücs, Gabriella, Stankovic, Aleksandra, Stamenkovic, Bojana, Selmi, Carlo Francesco, Santis, Maria De, Marasini, Bianca, Coleiro, Bernard, Santamaria, Vera Ortiz, Westhovens, René, Becvár, Radim, Novak, Srdan, Engelhart, Merete, Meroni, Pierluigi, Ingegnoli, Francesca, Zeni, Silvana, Sulli, Alberto, Distler, Jörg, Yavuz, Sule, Montecucco, Carlomaurizio, Eyerich, Kilian, Krummel Lorenz, Brigitte, Zenone, Thierry, Midtvedt, Øyvind, Chizzolini, Carlo, Seidel, Matthias, Oleszowsky, Mara, Üprus, Maria, Opriş, Daniela, Groseanu, Laura, Bielecka, Otylia Kowal, Antonio, Zea Mendoza, Szechinski, Jacek, Morovic Vergles, Jadranka, Scorza, Raffaella, Puppo, Francesco, Mathieu, Alessandro, Anic, Branimir, Stork, Jiri, Stebbings, Simon, Inanc, Murat, Hasler, Paul, Von Mühlen, Carlos Alberto, Aringer, Martin, Popa, Sergei, Mengtao, Li, Rosato, Edoardo, University of Zurich, and Mihai, Carina
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Genetics and Molecular Biology (all) ,Lung Diseases ,Male ,0301 basic medicine ,Databases, Factual ,Epidemiology ,2745 Rheumatology ,Vital Capacity ,Disease ,Biochemistry ,Scleroderma ,Systemic autoimmune disease ,High morbidity ,0302 clinical medicine ,Cardiovascular Disease ,Immunology and Allergy ,Medicine (all) ,10051 Rheumatology Clinic and Institute of Physical Medicine ,Systemic Sclerosis ,Adult ,Aged ,Cardiovascular Diseases ,Disease Progression ,Female ,Hand Dermatoses ,Humans ,Hypertension, Pulmonary ,Kidney Diseases ,Middle Aged ,Multivariate Analysis ,Prognosis ,Proportional Hazards Models ,Pulmonary Diffusing Capacity ,Retrospective Studies ,Scleroderma, Systemic ,Skin Ulcer ,Stroke Volume ,Fingers ,Rheumatology ,Immunology ,Biochemistry, Genetics and Molecular Biology (all) ,Orvostudományok ,Pulmonary ,Hypertension ,2723 Immunology and Allergy ,medicine.medical_specialty ,610 Medicine & health ,Klinikai orvostudományok ,General Biochemistry, Genetics and Molecular Biology ,Disease course ,Databases ,03 medical and health sciences ,1300 General Biochemistry, Genetics and Molecular Biology ,Internal medicine ,Cox proportional hazards regression ,medicine ,In patient ,Factual ,030203 arthritis & rheumatology ,2403 Immunology ,business.industry ,Systemic ,medicine.disease ,030104 developmental biology ,Physical therapy ,business - Abstract
ObjectiveSystemic sclerosis (SSc) is a systemic autoimmune disease with high morbidity and significant mortality. There is a great need of predictors that would allow risk stratification of patients with SSc and ultimately initiation of treatment early enough to ensure optimal clinical results. In this study, we evaluated whether a history of digital ulcers (HDU) at presentation may be a predictor of vascular outcomes and of overall clinical worsening and death in patients with SSc.MethodsPatients from the EULAR Scleroderma Trials and Research (EUSTAR) database, satisfying at inclusion the 1980 American College of Rheumatology classification criteria for SSc, who had a follow-up of at least 3 years since baseline or who have died, were included in the analysis. HDU at presentation as a predictor of disease worsening or death was evaluated by Cox proportional hazards regression analysis.Results3196 patients matched the inclusion criteria (male sex 13.2%, 33.4% diffuse subset). At presentation, 1092/3196 patients had an HDU (34.1%). In multivariable analysis adjusting for age, gender and all parameters considered potentially significant, HDU was predictive for the presence of active digital ulcers (DUs) at prospective visits (HR (95% CI)): 2.41 (1.91 to 3.03), pConclusionsIn patients with SSc, HDU at presentation predicts the occurrence of DUs at follow-up and is associated with cardiovascular worsening and decreased survival.
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- 2015
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15. Predictive value of different questionnaires for diagnosing Psoriatic Arthritis in patients with Psoriasis in daily routine care
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Köhm, Michaela, Dauth, Stephanie, Rossmanith, Tanja, Langer, Hans-Eckhard, Burmester, Gerd-Rüdiger, Käßer, Ulrich, Backhaus, Marina, Wassenberg, Siegfried, Köhler, Benjamin, Burkhardt, Harald Louis, and Behrens, Frank
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Background: Psoriasis (PsO) is one of the most common chronic inflammatory skin disease in Europe, with at least 100 million individuals affected worldwide. Approximately 34.7% of the individuals with psoriasis develop psoriatic arthritis (PsA) which leads to joint deformations and disability. [for full text, please go to the a.m. URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2017
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16. Impact of different dosages of rituximab in combination with leflunomide as retreatment on efficacy and safety measurements in patients with rheumatoid arthritis (AMARA-study)
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Behrens, Frank, Köhm, Michaela, Rossmanith, Tanja, Dauth, Stephanie, Alten, Rieke H.-E., Burmester, Gerd-Rüdiger, Feist, Eugen, Aringer, Martin, Krüger, Klaus, Müller-Ladner, Ulf, Rubbert-Roth, Andrea, Wassenberg, Siegfried, Tony, Hans-Peter, Kellner, Herbert, Backhaus, Marina, and Burkhardt, Harald Louis
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musculoskeletal diseases ,ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Background: In Rheumatoid Arthritis (RA) treatment with biologics such as Rituximab (RTX) is effective, but often only licensed in combination with methotrexate (MTX). Different dosing strategies for RTX-retreatment are applied in routine care. The aim of this placebo(PLA)-controlled multicenter German[for full text, please go to the a.m. URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2017
17. An objective automated measurement of fluorescence-signal intensities in Fluorescence-Optical Imaging technique can classify early non-response of antiTNF treatment in Psoriatic Arthritis patients - interims analysis of the XPLORE-study
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Köhm, Michaela, Rossmanith, Tanja, Henkemeier, Ulf, Aries, Peer, Alten, Rieke H.-E., Langer, Hans-Eckhard, Burkhardt, Harald Louis, and Behrens, Frank
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musculoskeletal diseases ,ddc: 610 ,Psoriasis ,610 Medical sciences ,Medicine ,skin and connective tissue diseases ,Fluoreszenz-optische Bildgebung ,Psoriasis Arthritis - Abstract
Background: Psoriatic arthritis (PsA) is a chronic inflammatory disorder associated with joint and musculoskeletal inflammation. After failure of NSAID and DMARD treatment, antiTNF therapy is started. In daily practice response is measured by clinical examination and calculated using composite indices[for full text, please go to the a.m. URL], 44. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 30. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 26. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2016
18. Combination of questionnaires for diagnosis of Psoriatic Arthritis and fluorescence-optical imaging technique in daily routine care: Enrichment of sensitivity for detection of subclinical signs of musculoskeletal inflammation in Psoriasis?
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Köhm, Michaela, Rossmanith, Tanja, Langer, Hans-Eckhard, Burmester, Gerd-Rüdiger, Köhler, Benjamin, Käßer, Ulrich, Backhaus, Marina, Burkhardt, Harald Louis, and Behrens, Frank
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ddc: 610 ,Psoriasis ,PEST ,610 Medical sciences ,Medicine ,PASE ,GEPARD ,urologic and male genital diseases ,Fluoreszenz-optische Bildgebung ,Psoriasis Arthritis - Abstract
Background: Psoriasis (Pso) is one of the most common chronic inflammatory skin diseases in Europe. Psoriatic arthritis (PsA) is closely associated to Pso and appears in up to 30% of Pso patients; the skin manifestation appears usually years before PsA. Questionnaires for detection of PsA (PASE,[for full text, please go to the a.m. URL], 44. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 30. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 26. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2016
19. Rituximab in combination with Leflunomide: Results from a multicenter randomized placebo controlled investigator initiated clinical trial in active Rheumatoid Arthritis (AMARA-Study)
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Behrens, Frank, Rossmanith, Tanja, Köhm, Michaela, Alten, Rieke H.-E., Aringer, Martin, Backhaus, Marina, Baerwald, Christoph G. O., Burmester, Gerd-Rüdiger, Feist, Eugen, Kellner, Herbert, Krüger, Klaus, Müller-Ladner, Ulf, Rubbert-Roth, Andrea, Tony, Hans-Peter, Wassenberg, Siegfried, Burkhardt, Harald Louis, and Publica
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musculoskeletal diseases ,ddc: 610 ,immune system diseases ,Rheumatoide Arthritis ,610 Medical sciences ,Medicine ,skin and connective tissue diseases ,Rituximab ,AMARA ,Leflunomide - Abstract
Background: Use of biologicals such as Rituximab (RTX) in Rheumatoid Arthritis (RA) is effective and often only licensed in combination with Methotrexate (MTX). In cases of contraindications to or intolerances of MTX, other cDMARDs are frequently used in routine care without data from RCTs. Methods:[for full text, please go to the a.m. URL], 44. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 30. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 26. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2016
20. Suchtverhalten als Problemfeld in der Transition
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Braner, Axel, Delbrück, Christiane, and Burkhardt, Harald Louis
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Suchtverhalten ,ddc: 610 ,Transition ,Adoleszenz ,610 Medical sciences ,Medicine - Abstract
Einleitung: Der Betreuungswechsel vom Kinderrheumatologen zum internistischen Rheumatologen, die so genannte Transition, stellt eine extrem vulnerable Phase für die Betreuung der adoleszenten Patientendar. Wesentliche Änderungen ergeben sich u.a. in der Betreuungsstruktur wie die Übernahme[zum vollständigen Text gelangen Sie über die oben angegebene URL], 44. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 30. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 26. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2016
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21. Rheumatoid Factor Status Is a Predictor of Osteoporosis in Patients with Psoriatic Arthritis
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Behrens, Frank, Köhm, Michaela, Scharbatke, Eva Christina, Schmalzing, Marc, Gnann, Holger, Lorenz, Hanns-Martin, Thaci, Diamant, and Burkhardt, Harald Louis
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ddc: 610 ,610 Medical sciences ,Medicine ,urologic and male genital diseases - Abstract
Introduction: Osteoporosis is an important comorbidity in patients with rheumatic diseases, but risk factors for osteoporosis in Psoriatic Arthritis (PsA) patients have not been explored. Methods: We evaluated baseline characteristics of active PsA patients enrolled in a German observational multicenter[for full text, please go to the a.m. URL], 43. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 29. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 25. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
- Published
- 2015
22. Measurement of individual critical differences in activity of Rheumatoid Arthritis: Confirmation and usage of DAS28-dcrit in Tocilizumab-treated patients with RA
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Behrens, Frank, Köhm, Michaela, Specker, Christof, Fliedner, Gerhard, Hofmann, Michael W., Lüthje, Rasmus, and Burkhardt, Harald Louis
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Krankheitsaktivität ,ddc: 610 ,Rheumatoide Arthritis ,DAS28 ,DAS28-dcrit ,610 Medical sciences ,Medicine - Abstract
Background: Normal fluctuations in disease-activity measurements are issues for evaluation of a therapeutic-response in daily practice in rheumatoid arthritis (RA) patients. To address this aspect we established a statistical approach to determine a critical difference (dcrit) that defines valid criterion[for full text, please go to the a.m. URL], 42. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 28. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 24. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2014
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23. Is anti-TNF Treatment response in peripheral Psoriatic Arthritis influenced by concomitant use of Methotrexate?
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Behrens, Frank, Köhm, Michaela, Arndt, Uta, Thaci, Diamant, Scharbatke, Eva Christina, Tony, Hans-Peter, and Burkhardt, Harald Louis
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ddc: 610 ,antiTNF-Therapie ,610 Medical sciences ,Medicine ,Psoriasis Arthritis - Abstract
Background: In active psoriatic arthritis (PsA) the efficacy of TNF-inhibitors (TNFi) has been proven in randomized clinical trials (RCT). Methotrexate (MTX) co-medication can improve the therapeutic benefit of TNFi in rheumatoid arthritis (RA), but its role in PsA remains unclear. Thus, distinct patterns[for full text, please go to the a.m. URL], 42. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 28. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 24. wissenschaftliche Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2014
24. Prediction of worsening of skin fibrosis in patients with diffuse cutaneous systemic sclerosis using the EUSTAR database
- Author
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Maurer, B., Graf, N., Michel, B. A., Muller Ladner, U., Czirjak, L., Denton, C. P., Tyndall, A., Metzig, C., Lanius, V., Khanna, D., Distler, O., Arner, I. H., Cerinic, M. M., Guiducci, S., Walker, U., Lapadula, G., Iannone, F., Becvar, R., Sierakowsky, S., Bielecka, O. K., Cutolo, M., Sulli, A., Valentini, G., Cuomo, G., Vettori, S., Riemekasten, G., Rednic, S., Nicoara, I., Kahan, A., Allanore, Y., Vlachoyiannopoulos, P., Montecucco, C., Caporali, R., Carreira, P. E., Novak, S., Varju, C., Chizzolini, C., Kucharz, E. J., Kotulska, A., Kopec Medrek, M., Widuchowska, M., Cozzi, F., Rozman, B., Mallia, C., Coleiro, B., Gabrielli, A., Farge, D., Hij, A., Airo, P., Hesselstrand, R., Scheja, A., Wollheim, F., Martinovic, D., Gurman, A. B., Braun Moscovici, Y., Govoni, Marcello, LO MONACO, Andrea, Hunzelmann, N., Pellerito, R., Bambara, L. M., Caramaschi, P., Black, C., Damjanov, N., Santamaria, V. O., Heitmann, S., Krasowska, D., Seidel, M., Oleszowsky, M., Burkhardt, H., Himsel, A., Salvador, M. J., Stamenkovic, B., Stankovic, A., Tikly, M., Starovoytova, M. N., Ananieva, L. P., Scorza, R., Engelhart, M., Strauss, G., Nielsen, H., Damgaard, K., Szucs, G., Mendoza, A. Z., Buijdos, C. d. l. P., Sifuentes Giraldo, W. A., Midtvedt, O., Garen, T., Hachulla, E., Launay, D., Valesini, G., Riccieri, V., Ionescu, R. M., Opris, D., Groseanu, L., Wigley, F. M., Mihai, C. M., Cornateanu, R. S., Ionitescu, R., Gherghe, A. M., Gorga, M., Dobrota, R., Bojinca, M., Schett, G., Distler, J. H., Meroni, P., Zeni, P., Mouthon, L., Keyser, F. D., Cantatore, F. P., Corrado, A., Ullman, S., Iversen, L., Pozzi, M. R., Eyerich, K., Hein, R., Knott, E., Szechinski, J., Wiland, P., Szmyrka Kaczmarek, M., Sokolik, R., Morgiel, E., Krummel Lorenz, B., Saar, P., Aringer, M., Gunther, C., Anic, B., Baresic, M., Mayer, M., Radominski, S. C., Muller, C. d. S., Azevedo, V. F., Agachi, S., Groppa, L., Chiaburu, L., Russu, E., Zenone, T., Highton, J., Stamp, L., Chapman, P., O'Donnell, J., Solanki, K., Doube, A., Veale, D., O'Rourke, M., Loyo, E., Li, M., Rosato, E., Pisarri, S., Tanaseanu, C. M., Popescu, M., Dumitrascu, A., Tiglea, I., Chirieac, R., Ancuta, C., Furst, D. E., Kafaja, S., Lefebvre, P. G. d. l. P., Rubio, S. R., Exposito, M. V., Sibilia, J., Chatelus, E., Gottenberg, J. E., Chifflot, H., Litinsky, I., Venalis, A., Butrimiene, I., Venalis, P., Rugiene, R., Karpec, D., Kerzberg, E., Montoya, F., Cosentino, V., Chizzolini, Carlo, Maurer, Britta, Graf, Nicole, Michel, Beat A, Müller Ladner, Ulf, Czirják, László, Denton, Christopher P, Tyndall, Alan, Metzig, Carola, Lanius, Vivian, Khanna, Dinesh, Distler, Oliver, Tarner, Ingo H, Cerinic, Marco Matucci, Guiducci, Serena, Walker, Ulrich, Lapadula, Giovanni, Iannone, Florenzo, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Cutolo, Maurizio, Sulli, Alberto, Valentini, Gabriele, Cuomo, Giovanna, Vettori, Serena, Riemekasten, Gabriele, Rednic, Simona, Nicoara, Ileana, Kahan, André, Allanore, Yannick, Vlachoyiannopoulos, P, Montecucco, Carlomaurizio, Caporali, Roberto, Carreira, Patricia E, Novak, Srdan, Varju, Cecilia, Kucharz, Eugene J, Kotulska, Anna, Kopec Medrek, Magdalena, Widuchowska, Malgorzata, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Hij, Adrian, Airò, Paolo, Hesselstrand, Roger, Scheja, Agneta, Wollheim, Frank, Martinovic, Duska, Gurman, Alexandra Balbir, Braun Moscovici, Yolanda, Govoni, M, Monaco, Andrea Lo, Hunzelmann, Nicola, Pellerito, Raffaele, Bambara, Lisa Maria, Caramaschi, Paola, Black, Carol, Damjanov, Nemanja, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthia, Oleszowsky, Mara, Burkhardt, Harald, Himsel, Andrea, Salvador, Maria J, Stamenkovic, Bojana, Stankovic, Aleksandra, Tikly, Mohammed, Starovoytova, Maya N, Ananieva, Lidia P, Scorza, Raffaella, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szücs, Gabriella, Mendoza, Antonio Zea, Buijdos, Carlos de la Puente, Giraldo, Walter A. Sifuente, Midtvedt, Øyvind, Garen, Torhild, Hachulla, Eric, Launay, David, Valesini, Guido, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Wigley, Fredrick M, Mihai, Carmen M, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Gorga, Marilena, Dobrota, Rucsandra, Bojinca, Mihai, Schett, Georg, Distler, Jörg HW, Meroni, Pierluigi, Zeni, Silvana, Mouthon, Luc, Keyser, Filip De, Cantatore, Francesco P, Corrado, Ada, Ullman, Susanne, Iversen, Line, Pozzi, Maria R, Eyerich, Kilian, Hein, Rüdiger, Knott, Elisabeth, Szechinski, Jacek, Wiland, Piotr, Szmyrka Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Krummel Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Günther, Claudia, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Radominski, Sebastião C, Müller, Carolina de Souza, Azevedo, Valderílio F, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Zenone, Thierry, Highton, John, Stamp, Lisa, Chapman, Peter, O'Donnell, John, Solanki, Kamal, Doube, Alan, Veale, Dougla, O’Rourke, Marie, Loyo, Esthela, Li, Mengtao, Rosato, Edoardo, Pisarri, Simonetta, Tanaseanu, Cristina Mihaela, Popescu, Monica, and University of Zurich
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Genetics and Molecular Biology (all) ,Male ,Time Factors ,Databases, Factual ,systemic sclerosis ,2745 Rheumatology ,computer.software_genre ,Biochemistry ,Severity of Illness Index ,Outcomes Research ,Qualitative Research ,Systemic Sclerosis ,Adult ,Cohort Studies ,Creatine Kinase ,Decision Support Techniques ,Deglutition Disorders ,Dyspnea ,Female ,Fibrosis ,Humans ,Logistic Models ,Middle Aged ,Multivariate Analysis ,Scleroderma, Diffuse ,Sex Factors ,Skin ,Synovitis ,Disease Progression ,Rheumatology ,Immunology ,Biochemistry, Genetics and Molecular Biology (all) ,Immunology and Allergy ,Medicine (all) ,Scleroderma ,skin fibrosis ,skin and connective tissue diseases ,ddc:616 ,EUSTAR ,Univariate analysis ,Database ,integumentary system ,10051 Rheumatology Clinic and Institute of Physical Medicine ,Orvostudományok ,Diffuse ,Connective tissue disease ,Cohort ,2723 Immunology and Allergy ,Cohort study ,medicine.medical_specialty ,610 Medicine & health ,Klinikai orvostudományok ,General Biochemistry, Genetics and Molecular Biology ,NO ,outcomes research ,qualitative research ,Databases ,1300 General Biochemistry, Genetics and Molecular Biology ,Internal medicine ,Severity of illness ,medicine ,Factual ,2403 Immunology ,business.industry ,medicine.disease ,business ,computer - Abstract
ObjectivesTo identify predictive parameters for the progression of skin fibrosis within 1 year in patients with diffuse cutaneous SSc (dcSSc).MethodsAn observational study using the EUSTAR database was performed. Inclusion criteria were dcSSc, American College of Rheumatology (ACR) criteria fulfilled, modified Rodnan skin score (MRSS) ≥7 at baseline visit, valid data for MRSS at 2nd visit, and available follow-up of 12±2 months. Worsening of skin fibrosis was defined as increase in MRSS >5 points and ≥25% from baseline to 2nd visit. In the univariate analysis, patients with progressive fibrosis were compared with non-progressors, and predictive markers with pResultsA total of 637 dcSSc patients were eligible. Univariate analyses identified joint synovitis, short disease duration (≤15 months), short disease duration in females/patients without creatine kinase (CK) elevation, low baseline MRSS (≤22/51), and absence of oesophageal symptoms as potential predictors for progressive skin fibrosis. In the multivariate analysis, by employing combinations of the predictors, 17 models with varying prediction success were generated, allowing cohort enrichment from 9.7% progressive patients in the whole cohort to 44.4% in the optimised enrichment cohort. Using a second validation cohort of 188 dcSSc patients, short disease duration, low baseline MRSS and joint synovitis were confirmed as independent predictors of progressive skin fibrosis within 1 year resulting in a 4.5-fold increased prediction success rate.ConclusionsOur study provides novel, evidence-based criteria for the enrichment of dcSSc cohorts with patients who experience worsening of skin fibrosis which allows improved clinical trial design.
- Published
- 2014
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