1. Influence of gut microbiota on eye diseases: an overview
- Author
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Ciro Costagliola, Mariaelena Filippelli, Sergio Davinelli, Roberto dell'Omo, Silvia Bartollino, Pasquale Napolitano, Napolitano, Pasquale, Filippelli, Mariaelena, Davinelli, Sergio, Bartollino, Silvia, Dell'Omo, Roberto, and Costagliola, Ciro
- Subjects
genetic structures ,Eye Diseases ,Eye disease ,eye disease ,Review Article ,030204 cardiovascular system & hematology ,Gut flora ,Bioinformatics ,digestive system ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,030212 general & internal medicine ,biology ,business.industry ,dysbiosi ,Microbiota ,General Medicine ,Macular degeneration ,medicine.disease ,biology.organism_classification ,eye diseases ,Gastrointestinal Microbiome ,Ophthalmology ,probiotics ,dysbiosis ,gut ,Dysbiosis ,Gut dysbiosis ,sense organs ,business ,Uveitis - Abstract
The microbiota is a dynamic ecosystem that plays a major role in the host health. Numerous studies have reported that alterations in the intestinal microbiota (dysbiosis) may contribute to the pathogenesis of various common diseases such as diabetes, neuropsychiatric diseases, and cancer. However, emerging findings also suggest the existence of a gut-eye axis, wherein gut dysbiosis may be a crucial factor influencing the onset and progression of multiple ocular diseases, including uveitis, dry eye, macular degeneration, and glaucoma. Currently, supplementation with pre- and probiotics appears is the most feasible and cost-effective approach to restore the gut microbiota to a eubiotic state and prevent eye pathologies. In this review, we discuss the current knowledge on how gut microbiota may be linked to the pathogenesis of common eye diseases, providing therapeutic perspectives for future translational investigations within this promising research field.
- Published
- 2021