Search

Your search keyword '"Barba, C."' showing total 14 results
Start Over Author "Barba, C." Topic medicine
14 results on '"Barba, C."'

1. Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation

Author

Barba, C., Cross, J. H., Braun, K., Cossu, M., Klotz, K. A., De Masi, S., Perez Jimenez, M. A., Gaily, E., Specchio, N., Cabral, P., Toulouse, J., Dimova, P., Battaglia, D., Freri, E., Consales, A., Cesaroni, E., Tarta-Arsene, O., Gil-Nagel, A., Mindruta, I., Di Gennaro, G., Giulioni, M., Tisdall, M. M., Eltze, C., Tahir, M. Z., Jansen, F., van Rijen, P., Sanders, M., Tassi, L., Francione, S., Lo Russo, G., Jacobs, J., Bast, T., Matta, G., Budke, M., Fournier del Castillo, C., Metsahonkala, E. -L., Karppinen, A., Ferreira, J. C., Minkin, K., Marras, C. E., Lucenteforte, E, Arzimanoglou, A., and Guerrini, R.

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Multivariate analysis, Adolescent, Neurosurgery, Stereoelectroencephalography, Neurosurgical Procedures, 03 medical and health sciences, Epilepsy, Settore MED/39 - NEUROPSICHIATRIA INFANTILE, 0302 clinical medicine, children, Seizures, Medicine, Humans, survey, Epilepsy surgery, Preschool, Child, Retrospective Studies, medicine.diagnostic_test, business.industry, Age Factors, Magnetic resonance imaging, Retrospective cohort study, Electroencephalography, medicine.disease, Magnetic Resonance Imaging, Temporal Lobe, 3. Good health, Surgery, Europe, epilepsy surgery, histopathology, outcome, Child, Preschool, Female, Treatment Outcome, 030104 developmental biology, Neurology, Histopathology, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

OBJECTIVE: To profile European trends in pediatric epilepsy surgery (

Published
2019

2. Individualized prediction of seizure relapse and outcomes following antiepileptic drug withdrawal after pediatric epilepsy surgery

Author

Lamberink, Herm J., Boshuisen, Kim, Otte, Willem M., Geleijns, Karin, Braun, K. P.J., Feucht, M., Gröppel, G., Kahane, P., Minotti, L., Arzimanoglou, A., Ryvlin, P., Panagiotakaki, E., de Bellescize, J., Ostrowsky-Coste, K., Hirsch, E., Valenti, M., Polster, T., Sassen, R., Hoppe, C., Kuczaty, S., Elger, C., Schubert, S., Strobl, K., Bast, T., Barba, C., Guerrini, R., Giordano, F., Francione, S., Caputo, D., Boshuisen, K., Uiterwaal, C. S.P.M., van Nieuwenhuizen, O., Leijten, F. S., van Rijen, P. C., Seeck, M., Yalnizoglu, D., Turanli, G., Topcu, M., Özkara, C., Uzan, M., Cross, J. H., D'Argenzio, L., and Harkness, W.

Subjects
Male, medicine.medical_specialty, Neurology, Concordance, Antiepileptic drug, Clinical Neurology, Seizure recurrence, nomogram, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Recurrence, Seizures, medicine, Humans, seizure freedom, 030212 general & internal medicine, Precision Medicine, Child, Retrospective Studies, Pediatric epilepsy, Epilepsy, business.industry, prediction, Nomogram, Seizure freedom, Confidence interval, Surgery, Substance Withdrawal Syndrome, Europe, Anticonvulsants, Female, Neurology (clinical), prognosis, seizure recurrence, business, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

The objective of this study was to create a clinically useful tool for individualized prediction of seizure outcomes following antiepileptic drug withdrawal after pediatric epilepsy surgery. We used data from the European retrospective TimeToStop study, which included 766 children from 15 centers, to perform a proportional hazard regression analysis. The 2 outcome measures were seizure recurrence and seizure freedom in the last year of follow-up. Prognostic factors were identified through systematic review of the literature. The strongest predictors for each outcome were selected through backward selection, after which nomograms were created. The final models included 3 to 5 factors per model. Discrimination in terms of adjusted concordance statistic was 0.68 (95% confidence interval [CI] 0.67-0.69) for predicting seizure recurrence and 0.73 (95% CI 0.72-0.75) for predicting eventual seizure freedom. An online prediction tool is provided on www.epilepsypredictiontools.info/ttswithdrawal. The presented models can improve counseling of patients and parents regarding postoperative antiepileptic drug policies, by estimating individualized risks of seizure recurrence and eventual outcome.

Published
2018
Full Text
View/download PDF

3. Histopathological findings in brain tissue obtained during epilepsy surgery

Author

Blümcke, I., Spreafico, R., Haaker, G., Coras, R., Kobow, K., Bien, C.G., Pfäfflin, M., Elger, C., Widman, G., Schramm, J., Becker, A., Braun, K.P.J., Leijten, F.S.S., Baayen, J.C., Aronica, E., Chassoux, F., Hamer, H., Stefan, H., Rössler, K., Thom, M., Walker, M.C., Sisodiya, S.M., Duncan, J.S., McEvoy, A.W., Pieper, T., Holthausen, H., Kudernatsch, M., Meencke, H.J., Kahane, P., Schulze-Bonhage, A., Zentner, J., Heiland, D., Urbach, H., Steinhoff, B.J., Bast, T., Tassi, L., Lo Russo, G., Ozkara, C., Oz, B., Krsek, P., Vogelgesang, S., Runge, U., Lerche, H., Weber, Y., Honavar, M., Pimentel, J., Arzimanoglou, A., Ulate-Campos, A., Noachtar, S., Hartl, E., Schijns, O.E.M.G., Guerrini, R., Barba, C., Jacques, T.S., Cross, J.H., Feucht, M., Mühlebner, A., Grunwald, T., Trinka, E., Winkler, P.A., Gil-Nagel, A., Toledano Delgado, R., Mayer, T., Lutz, M., Zountsas, B., Garganis, K., Rosenow, F., Hermsen, A., Örtzen, T.J. von, Diepgen, T.L., Avanzini, G., Aparicio, J., Bento, C., Beckervordersandforth, J., Buccoliero, A.M., Cabral, P., Chamadoira, C., Colon, A.J., Chabardès, S., Carpenter, S., Czech, T., Dressler, A., Deleo, F., Dílio, A., Dings, J., Devaux, B., De Tisi, J., De Bellescize, J., Ebner, A., Franke, K., Groeppel, G., Giordano, F., Gozzo, F., Garbelli, R., Guenot, M., García‐Morales, I., Gómez‐Angulo, J.C., Garcia, G., Hainfellner, J.A., Höfler, J., Hoogland, G., Hendriks, M.P.H., Hofman, P., Harding, B., Huppertz, H.J., Herms, J., Hilkman, D.M.W., Hamelin, S., Idema, S., Jansen, F.E., Jahodova, A., Keeley, A., Kalss, G., Kudr, M., Kroell, J., Kokkinos, V., Keo Kosal, P., Kalbhenn, T., Leitinger, M., Landré, E., Melo Pires, M., Matas, A., Mann, M.W., Ostrowsky‐Coste, K., Prinz, M., Puttinger, G., Peraud, A., Rangel Pinho, R., Romero, C., Rego, R., Rouhl, R.P.W., Ryvlin, P., Rumia, J., Rampp, S., Scholl, T., Schulz, R., Stone, T.J., Streichenberger, N., Tisdall, M., Turak, B., Taipa, R., Uzan, M., Kranen‐Mastenbroek, V. van, Varlet, P., Vlooswijk, M.C.G., Wagner, L., Weis, S., Neurosurgery, Amsterdam Neuroscience - Systems & Network Neuroscience, Verpleging & Verzorging, RS: MHeNs - R3 - Neuroscience, MUMC+: MA Med Staf Spec Neurochirurgie (9), MUMC+: MA Med Staf Artsass Cardiologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: HZC Med Staf Spec Klinische Neurofys (9), Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), MUMC+: MA Niet Med Staf Neurochirurgie (9), APH - Mental Health, APH - Aging & Later Life, Pathology, and ANS - Amsterdam Neuroscience

Subjects
Male, 0301 basic medicine, Pediatrics, ILAE COMMISSION, Disease, Hippocampus, Epilepsy, PROPOSAL, 0302 clinical medicine, DIAGNOSTIC METHODS, TEMPORAL-LOBE EPILEPSY, Epilepsy surgery, Age of Onset, Child, Medicine(all), Brain Neoplasms, Age Factors, Brain, General Medicine, DEPDC5, Temporal Lobe, Europe, Malformations of Cortical Development, Databases as Topic, Female, TRIAL, Current Literature In Clinical Science, Adult, TASK-FORCE REPORT, medicine.medical_specialty, Neuropathology, CONSENSUS CLASSIFICATION, Temporal lobe, 03 medical and health sciences, medicine, Humans, Hippocampal sclerosis, Neuro- en revalidatiepsychologie, business.industry, Neuropsychology and rehabilitation psychology, Plasticity and Memory [DI-BCB_DCC_Theme 3], medicine.disease, TRENDS, Surgery, 030104 developmental biology, EXPERIENCE, Age of onset, business, 030217 neurology & neurosurgery
Abstract

Item does not contain fulltext Background: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. Methods: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%). Results: The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of the patients (88.7% of cases were in adults), tumors (mainly ganglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of cases of which were in children). No histopathological diagnosis could be established for 7.7% of the patients. Conclusions: In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.) 9 p.

Published
2017
Full Text
View/download PDF

4. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies

Author

Barba, C., Cavalli-Sforza, T., Cutter, J., Darnton-Hill, I., Deurenberg, P., Deurenberg-Yap, M., Gill, T., James, P., Ko, G., Miu, A.H., Kosulwat, V., Kumanyika, S., Kurpad, A., Mascie-Taylor, N., Moon, H.K., Nishida, C., Noor, M.I., Reddy, K.S., Rush, P.S., Schultz, J.T., Seidell, J.C., Stevens, J., Swinburn, B., Tan, K., Weisell, R., Wu, Z.S., Yajnik, C.S., Yoshiike, N., Zimmet, P.Z., and Nutrition and Health

Subjects
Gerontology, medicine.medical_specialty, Consultants, Population, World Health Organization, Body Mass Index, Absorptiometry, Photon, SDG 3 - Good Health and Well-being, Asian People, Classification of obesity, Reference Values, Risk Factors, Medicine, Humans, Obesity, Deuterium Oxide, education, Health policy, education.field_of_study, Anthropometry, business.industry, Public health, Health Policy, Body Weight, nutritional and metabolic diseases, Reproducibility of Results, General Medicine, medicine.disease, Intervention (law), Risk IT, business, Body mass index, Demography, Densitometry
Abstract

A WHO expert consultation addressed the debate about interpretation of recommended body-mass index (BMI) cut-off points for determining overweight and obesity in Asian populations, and considered whether population-specific cut-off points for BMI are necessary. They reviewed scientific evidence that suggests that Asian populations have different associations between BMI, percentage of body fat, and health risks than do European populations. The consultation concluded that the proportion of Asian people with a high risk of type 2 diabetes and cardiovascular disease is substantial at BMIs lower than the existing WHO cut-off point for overweight (≥25 kg/m2). However, available data do not necessarily indicate a clear BMI cut-off point for all Asians for overweight or obesity. The cut-off point for observed risk varies from 22 kg/m2 to 25 kg/m2 in different Asian populations; for high risk it varies from 26 kg/m2 to 31 kg/m 2. No attempt was made, therefore, to redefine cut-off points for each population separately. The consultation also agreed that the WHO BMI cut-off points should be retained as international classifications. The consultation identified further potential public health action points (23.0, 27.5, 32.5, and 37.5 kg/m2) along the continuum of BMI, and proposed methods by which countries could make decisions about the definitions of increased risk for their population.

Published
2004
Full Text
View/download PDF

5. Treatment of Parkinson's disease with L-DOPA and an association L-DOPA plus a DOPA decarboxylase inhibitor

Author

Ruggieri S, F. Volante, C Fazio, Barba C, M. Reitano, A. Agnoli, and Casacchia M

Subjects
Male, medicine.medical_specialty, Neurology, Parkinson's disease, Gastrointestinal Diseases, Decarboxylase inhibitor, Administration, Oral, macromolecular substances, Internal medicine, medicine, Humans, Aromatic L-amino acid decarboxylase, business.industry, Parkinsonism, fungi, food and beverages, Drug Synergism, Parkinson Disease, medicine.disease, nervous system diseases, Dihydroxyphenylalanine, Endocrinology, Hydrazines, Female, Neurology (clinical), Hypotension, business
Abstract

l-DOPA therapy of Parkinsonism by mouth, today universally accepted, may induce undesirable effects which can sometimes be of a certain severity.

Published
1972

6. Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial

Author

Ursula Ferri, Debora Girgenti, Roberto Crocchiolo, Claudia Barba, Clara Cesana, Lara Crucitti, Giovanni Grillo, Silvano Rossini, Giambattista Bertani, Roberto Cairoli, Giuseppa Liga, Crocchiolo, R, Cesana, C, Girgenti, D, Bertani, G, Barba, C, Liga, G, Ferri, U, Crucitti, L, Grillo, G, Rossini, S, and Cairoli, R

Subjects
Cancer Research, medicine.medical_specialty, T regulatory cells, Extracorporeal photopheresis, chemical and pharmacologic phenomena, Disease, Gastroenterology, lcsh:RC254-282, Graft-versus-host disease, 03 medical and health sciences, 0302 clinical medicine, Extracorporeal photopheresi, Internal medicine, Extracorporeal Photopheresis, medicine, In patient, T regulatory cell, Letter to the Editor, Hematology, business.industry, lcsh:RC633-647.5, Correction, hemic and immune systems, lcsh:Diseases of the blood and blood-forming organs, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Peripheral, Clinical trial, surgical procedures, operative, Oncology, 030220 oncology & carcinogenesis, Potential biomarkers, Allogeneic hematopoietic stem cell transplantation, business, 030215 immunology
Abstract

The aim of the present study was to evaluate the circulating T regulatory cells (Tregs) in patients undergoing extracorporeal photopheresis (ECP) for the prevention of chronic graft-versus-host disease (GvHD) and to search for any correlation between Tregs counts and chronic GvHD occurrence. Among n = 12 patients with complete longitudinal data, the median cumulative values of absolute peripheral Tregs counts were 21.64 and 63.49 cells/µL for patients who developed chronic GvHD and those who did not develop it, respectively (p = 0.05). The analysis of the median absolute counts of peripheral HLA-DR + Tregs provided similar results, showing that 20% (1 out of 5) and 100% (7 out of 7) of patients with HLA-DR + Tregs values of > 5 cells/µL were in the GvHD and non-GvHD groups, respectively (p = 0.01). In conclusion, the present results support the involvement of Tregs in the prevention of chronic GvHD in patients receiving ECP and suggest Tregs count as a potential biomarker of ECP effectiveness. Future strategies are needed to enhance Tregs expansion and/or activity in conjunction with ECP for an effective chronic GvHD prevention.

Published
2021

7. Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals

Author

Joshua E. Motelow, Gundula Povysil, Ryan S. Dhindsa, Kate E. Stanley, Andrew S. Al- len, Yen-Chen Anne Feng, Daniel P. Howrigan, Liam E. Abbott, Ka- therine Tashman, Felecia Cerrato, Caroline Cusick, Tarjinder Singh, Henrike Heyne, Andrea E. Byrnes, Claire Churchhouse, Nick Watts, Matthew Solomonson, Dennis Lal, Namrata Gupta, Benjamin M. Neale, Gianpiero L. Cavalleri, Patrick Cossette, Chris Cotsapas, Peter De Jonghe, Tracy Dixon-Salazar, Renzo Guerrini, Hakon Hakonarson, Erin L. Heinzen, Ingo Helbig, Patrick Kwan, Anthony G. Marson, Slave ? Petrovski, Sitharthan Kamalakaran, Sanjay M. Sisodiya, Randy Stewart, Sarah Weckhuysen, Chantal Depondt, Dennis J. Dlugos, Ingrid E. Scheffer, Pasquale Striano, Catharine Freyer, Roland Krause, Patrick May, Kevin McKenna, Brigid M. Regan, Caitlin A. Bennett, Costin Leu, Stephanie L. Leech, Terence J. O'Brien, Marian Todaro, Hannah Stamberger, Danielle M. Andrade, Quratulain Zulfiqar Ali, Tara R. Sadoway, Heinz Krestel, Andre ? Schaller, Savvas S. Papacostas, Ioanna Kou- siappa, George A. Tanteles, Yiolanda Christou, Katalin Sterbova ?, Marke ? ta Vlckova ?, Lucie Sedlackova, Petra Lassuthova ?, Karl Martin Klein, Felix Rosenow, Philipp S. Reif, Susanne Knake, Bernd A. Neubauer, Friedrich Zimprich, Martha Feucht, Eva M. Reinthaler, Wolfram S. Kunz, Ga ?bor Zsurka, Rainer Surges, Tobias Baumgart- ner, Randi von Wrede, Manuela Pendziwiat, Hiltrud Muhle, An- nika Rademacher, Andreas van Baalen, Sarah von Spiczak, Ulrich Stephani, Zaid Afawi, Amos D. Korczyn, Moien Kanaan, Christina Canavati, Gerhard Kurlemann, Karen Mu ?ller-Schlu ?ter, Gerhard Kluger, Martin Ha ?usler, Ilan Blatt, Johannes R. Lemke, Ilona Krey, Yvonne G. Weber, Stefan Wolking, Felicitas Becker, Stephan Lauxmann, Christian Boßelmann, Josua Kegele, Christian Hengs- bach, Sarah Rau, Bernhard J. Steinhoff, Andreas Schulze-Bonhage, IngoBorggra ?fe, ChristophJ.Schankin, SusanneSchubert-Bast, Herbert Schreiber, Thomas Mayer, Rudolf Korinthenberg, Knut Brockmann, Markus Wolff, Dieter Dennig, Rene Madeleyn, Reetta Ka ?lvia ?inen, Anni Saarela, Oskari Timonen, Tarja Linnankivi, Anna-Elina Lehesjoki, Sylvain Rheims, Gaetan Lesca, Philippe Ryvlin, Louis Maillard, Luc Valton, Philippe Derambure, Fabrice Bartolomei, Edouard Hirsch, Ve ?ronique Michel, Francine Chas- soux, Mark I. Rees, Seo-Kyung Chung, William O. Pickrell, Robert Powell, Mark D. Baker, Beata Fonferko-Shadrach, Charlotte Law- thom, Joseph Anderson, Natascha Schneider, Simona Balestrini, Sara Zagaglia, Vera Braatz, Michael R. Johnson, Pauls Auce, Graeme J. Sills, Larry W. Baum, Pak C. Sham, Stacey S. Cherny, Colin H.T. Lui, Norman Delanty, Colin P. Doherty, Arif Shukralla, Hany El-Naggar, Peter Widdess-Walsh, Nina Barisic, Laura 12 The American Journal of Human Genetics 108, 1-18, June 3, 2021 Please cite this article in press as: Epi25 Collaborative, Sub-genic intolerance, ClinVar, the epilepsies: A whole-exome sequencing study of 29, 165 individuals, The American Journal of Human Genetics (2021), https://doi.org/10.1016/j.ajhg.2021.04.009 Canafoglia, Silvana Franceschetti, Barbara Castellotti, Tiziana Granata, Francesca Ragona, Federico Zara, Michele Iacomino, An- tonella Riva, Francesca Madia, Maria Stella Vari, Vincenzo Salpie- tro, Marcello Scala, Maria Margherita Mancardi, Lino Nobili, Elisa- betta Amadori, Thea Giacomini, Francesca Bisulli, Tommaso Pippucci, Laura Licchetta, Raffaella Minardi, Paolo Tinuper, Lor- enzo Muccioli, Barbara Mostacci, Antonio Gambardella, Angelo Labate, Grazia Annesi, Lorella Manna, Monica Gagliardi, Elena Parrini, Davide Mei, Annalisa Vetro, Claudia Bianchini, Martino Montomoli, Viola Doccini, Carmen Barba, Shinichi Hirose, At- sushi Ishii, Toshimitsu Suzuki, Yushi Inoue, Kazuhiro Yamakawa, Ahmad Beydoun, Wassim Nasreddine, Nathalie Khoueiry Zgheib, Birute Tumiene, Algirdas Utkus, Lynette G. Sadleir, Chontelle King, S. Hande Caglayan, Mutluay Arslan, Zuhal Yap?c?, P?nar To- paloglu, Bulent Kara, Uluc Yis, Dilsad Turkdogan, Asl? Gun- dogdu-Eken, Nerses Bebek, Meng-Han Tsai, Chen-Jui Ho, Chih- Hsiang Lin, Kuang-Lin Lin, I-Jun Chou, Annapurna Poduri, Beth R. Shiedley, Catherine Shain, Jeffrey L. Noebels, Alicia Goldman, Robyn M. Busch, Lara Jehi, Imad M. Najm, Lisa Ferguson, Jean Khoury, Tracy A. Glauser, Peggy O. Clark, Russell J. Buono, Thomas N. Ferraro, Michael R. Sperling, Warren Lo, Michael Privitera, Jac- queline A. French, Steven Schachter, Ruben I. Kuzniecky, Orrin Devinsky, Manu Hegde, David A. Greenberg, Colin A. Ellis, Ethan Goldberg, Katherine L. Helbig, Mahgenn Cosico, Priya Vaidis- waran, Eryn Fitch, Samuel F. Berkovic, Holger Lerche, Daniel H. Lowenstein, David B. Goldstein., Motelow J.E., Povysil G., Dhindsa R.S., Stanley K.E., Allen A.S., Feng Y.-C.A., Howrigan D.P., Abbott L.E., Tashman K., Cerrato F., Cusick C., Singh T., Heyne H., Byrnes A.E., Churchhouse C., Watts N., Solomonson M., Lal D., Gupta N., Neale B.M., Cavalleri G.L., Cossette P., Cotsapas C., De Jonghe P., Dixon-Salazar T., Guerrini R., Hakonarson H., Heinzen E.L., Helbig I., Kwan P., Marson A.G., Petrovski S., Kamalakaran S., Sisodiya S.M., Stewart R., Weckhuysen S., Depondt C., Dlugos D.J., Scheffer I.E., Striano P., Freyer C., Krause R., May P., McKenna K., Regan B.M., Bennett C.A., Leu C., Leech S.L., O'Brien T.J., Todaro M., Stamberger H., Andrade D.M., Ali Q.Z., Sadoway T.R., Krestel H., Schaller A., Papacostas S.S., Kousiappa I., Tanteles G.A., Christou Y., Sterbova K., Vlckova M., Sedlackova L., Lassuthova P., Klein K.M., Rosenow F., Reif P.S., Knake S., Neubauer B.A., Zimprich F., Feucht M., Reinthaler E.M., Kunz W.S., Zsurka G., Surges R., Baumgartner T., von Wrede R., Pendziwiat M., Muhle H., Rademacher A., van Baalen A., von Spiczak S., Stephani U., Afawi Z., Korczyn A.D., Kanaan M., Canavati C., Kurlemann G., Muller-Schluter K., Kluger G., Hausler M., Blatt I., Lemke J.R., Krey I., Weber Y.G., Wolking S., Becker F., Lauxmann S., Bosselmann C., Kegele J., Hengsbach C., Rau S., Steinhoff B.J., Schulze-Bonhage A., Borggrafe I., Schankin C.J., Schubert-Bast S., Schreiber H., Mayer T., Korinthenberg R., Brockmann K., Wolff M., Dennig D., Madeleyn R., Kalviainen R., Saarela A., Timonen O., Linnankivi T., Lehesjoki A.-E., Rheims S., Lesca G., Ryvlin P., Maillard L., Valton L., Derambure P., Bartolomei F., Hirsch E., Michel V., Chassoux F., Rees M.I., Chung S.-K., Pickrell W.O., Powell R., Baker M.D., Fonferko-Shadrach B., Lawthom C., Anderson J., Schneider N., Balestrini S., Zagaglia S., Braatz V., Johnson M.R., Auce P., Sills G.J., Baum L.W., Sham P.C., Cherny S.S., Lui C.H.T., Delanty N., Doherty C.P., Shukralla A., El-Naggar H., Widdess-Walsh P., Barisic N., Canafoglia L., Franceschetti S., Castellotti B., Granata T., Ragona F., Zara F., Iacomino M., Riva A., Madia F., Vari M.S., Salpietro V., Scala M., Mancardi M.M., Nobili L., Amadori E., Giacomini T., Bisulli F., Pippucci T., Licchetta L., Minardi R., Tinuper P., Muccioli L., Mostacci B., Gambardella A., Labate A., Annesi G., Manna L., Gagliardi M., Parrini E., Mei D., Vetro A., Bianchini C., Montomoli M., Doccini V., Barba C., Hirose S., Ishii A., Suzuki T., Inoue Y., Yamakawa K., Beydoun A., Nasreddine W., Khoueiry Zgheib N., Tumiene B., Utkus A., Sadleir L.G., King C., Caglayan S.H., Arslan M., Yapici Z., Topaloglu P., Kara B., Yis U., Turkdogan D., Gundogdu-Eken A., Bebek N., Tsai M.-H., Ho C.-J., Lin C.-H., Lin K.-L., Chou I.-J., Poduri A., Shiedley B.R., Shain C., Noebels J.L., Goldman A., Busch R.M., Jehi L., Najm I.M., Ferguson L., Khoury J., Glauser T.A., Clark P.O., Buono R.J., Ferraro T.N., Sperling M.R., Lo W., Privitera M., French J.A., Schachter S., Kuzniecky R.I., Devinsky O., Hegde M., Greenberg D.A., Ellis C.A., Goldberg E., Helbig K.L., Cosico M., Vaidiswaran P., Fitch E., Berkovic S.F., Lerche H., Lowenstein D.H., Goldstein D.B., Epi25 Collaborative, Institut de Neurosciences des Systèmes (INS), and Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
0301 basic medicine, focal epilepsy, Whole Exome Sequencing, Cohort Studies, Epilepsy, 0302 clinical medicine, Genetic Marker, Missense mutation, Exome, whole-exome sequencing, generalized epilepsy, ComputingMilieux_MISCELLANEOUS, Genetics (clinical), Exome sequencing, seizures, Genetics, ClinVar, Phenotype, epileptic encephalopathy, Epi25, intolerance, Case-Control Studie, Human, Genetic Markers, seizure, Disease Association, Biology, Article, 03 medical and health sciences, Exome Sequencing, medicine, Humans, Genetic Predisposition to Disease, Genetic Testing, Generalized epilepsy, Gene, Louvain, [SCCO.NEUR]Cognitive science/Neuroscience, Correction, Genetic Variation, medicine.disease, epilepsy, Human genetics, 030104 developmental biology, Case-Control Studies, Human medicine, Cohort Studie, Genetic generalized epilepsy, 030217 neurology & neurosurgery
Abstract

Summary Both mild and severe epilepsies are influenced by variants in the same genes, yet an explanation for the resulting phenotypic variation is unknown. As part of the ongoing Epi25 Collaboration, we performed a whole-exome sequencing analysis of 13,487 epilepsy-affected individuals and 15,678 control individuals. While prior Epi25 studies focused on gene-based collapsing analyses, we asked how the pattern of variation within genes differs by epilepsy type. Specifically, we compared the genetic architectures of severe developmental and epileptic encephalopathies (DEEs) and two generally less severe epilepsies, genetic generalized epilepsy and non-acquired focal epilepsy (NAFE). Our gene-based rare variant collapsing analysis used geographic ancestry-based clustering that included broader ancestries than previously possible and revealed novel associations. Using the missense intolerance ratio (MTR), we found that variants in DEE-affected individuals are in significantly more intolerant genic sub-regions than those in NAFE-affected individuals. Only previously reported pathogenic variants absent in available genomic datasets showed a significant burden in epilepsy-affected individuals compared with control individuals, and the ultra-rare pathogenic variants associated with DEE were located in more intolerant genic sub-regions than variants associated with non-DEE epilepsies. MTR filtering improved the yield of ultra-rare pathogenic variants in affected individuals compared with control individuals. Finally, analysis of variants in genes without a disease association revealed a significant burden of loss-of-function variants in the genes most intolerant to such variation, indicating additional epilepsy-risk genes yet to be discovered. Taken together, our study suggests that genic and sub-genic intolerance are critical characteristics for interpreting the effects of variation in genes that influence epilepsy.

Published
2021
Full Text
View/download PDF

8. The surgical treatment of epilepsy

Author

Carmen Barba, Luca De Palma, Giampaolo Vatti, Alessandro Consales, Sofia Asioli, Massimo Cossu, Giancarlo Di Gennaro, Flavio Villani, Sara Casciato, Carlo Efisio Marras, Gabriella Colicchio, Massimo Caulo, Alessandra Morano, Nelia Zamponi, Laura Tassi, Consales A., Casciato S., Asioli S., Barba C., Caulo M., Colicchio G., Cossu M., de Palma L., Morano A., Vatti G., Villani F., Zamponi N., Tassi L., Di Gennaro G., and Marras C.E.

Subjects
medicine.medical_specialty, Referral, Dermatology, Commission, Neurosurgical Procedure, Palliative surgery, Neurosurgical Procedures, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Resource (project management), Epilepsy surgery, medicine, Humans, 030212 general & internal medicine, Surgical treatment, Referral and Consultation, Drug-resistant, Neuromodulation, Patient Selection, Neurosciences, General Medicine, Pre-surgical evaluation, medicine.disease, Psychiatry and Mental health, Neurology (clinical), Neurosurgery, Medical emergency, Psychology, Surgically remediable syndrome, 030217 neurology & neurosurgery, Human
Abstract

In 2009, the Commission for Epilepsy Surgery of the Italian League Against Epilepsy (LICE) conducted an overview about the techniques used for the pre-surgical evaluation and the surgical treatment of epilepsies. The recognition that, in selected cases, surgery can be considered the first-line approach, suggested that the experience gained by the main Italian referral centers should be pooled in order to provide a handy source of reference. In light of the progress made over these past years, some parts of that first report have accordingly been updated. The present revision aims to harmonize the general principles regulating the patient selection and the pre-surgical work-up, as well as to expand the use of epilepsy surgery, that still represents an underutilized resource, regrettably. The objective of this contribution is drawing up a methodological framework within which to integrate the experiences of each group in this complex and dynamic sector of the neurosciences.

Published
2020

9. Urology in the Time of Coronavirus: Reduced Access to Urgent and Emergent Urological Care during the Coronavirus Disease 2019 Outbreak in Italy

Author

Fabrizio Di Maida, Stefano Zaramella, Silvana Di Bello, Antonio Luigi Pastore, Mario Falsaperla, Valerio Iacovelli, Antonio Celia, Carlo Terrone, Virginia Varca, Daniele D'Agostino, Giovanni Cacciamani, Fabrizio Gallo, Alessandro Volpe, Giorgio Bozzini, Costantino Leonardo, Carmine Sciorio, Luca Cindolo, Michele Colicchia, Antonio Tufano, Bernardo Rocco, Ciro Barba, Luigi Pucci, Gian Maria Busetto, Angelo Cafarelli, Paolo Umari, Andrea Minervini, Lorenzo Bianchi, Lorenzo Gatti, Daniele Romagnoli, Vincenzo Altieri, Alexandra Wennberg, Maria Angela Cerruto, Maria Chiara Sighinolfi, Giovannalberto Pini, Lorenzo Spirito, Marco Borghesi, Andrea Mari, Orietta Dalpiaz, Mattia Nidini, Francesco Greco, Michele Amenta, Giovanni Ferrari, Pierluigi Bove, Roberto Falabella, Giacomo Maria Pirola, Filippo Annino, Marco Pirozzi, Angelo Porreca, Alfio Corsaro, Maurizio Schenone, Riccardo Schiavina, Marco Oderda, Paolo Parma, Walter Artibani, Marinella Finocchiaro, Carlo Ceruti, Paolo Verze, Carlo Marenghi, Luisa Zegna, Alessandro Antonelli, Yazan Al Salhi, Alberto Calori, Porreca A., Colicchia M., D'Agostino D., Amenta M., Corsaro A., Zaramella S., Zegna L., Gallo F., Schenone M., Bozzini G., Calori A., Pastore A.L., Al Salhi Y., Sciorio C., Spirito L., Varca V., Marenghi C., Greco F., Altieri V.M., Verze P., Barba C., Antonelli A., Cerruto M.A., Falabella R., Di Bello S., Leonardo C., Tufano A., Volpe A., Umari P., Parma P., Nidini M., Pini G., Borghesi M., Terrone C., Cacciamani G.E., Sighinolfi M.C., Busetto G.M., Wennberg A.M., Finocchiaro M., Falsaperla M., Oderda M., Ceruti C., Rocco B., Schiavina R., Bianchi L., Mari A., Di Maida F., Dalpiaz O., Celia A., Pirozzi M., Bove P., Iacovelli V., Cafarelli A., Cindolo L., Ferrari G., Gatti L., Pirola G., Annino F., Pucci L., Romagnoli D., Artibani W., and Minervini A.

Subjects
030232 urology & nephrology, Disease, regression analysis, Health Services Accessibility, 0302 clinical medicine, Urological care, Pandemic, Ambulatory Care, Surveys and Questionnaire, Urologic Disease, coronavirus disease 2019, Italy, outbreak, urological care, ambulatory care, betacoronavirus, coronavirus infections, disease outbreaks, health services accessibility, hospitals, humans, pandemics, pneumonia, viral, surveys and questionnaires, urologic diseases, urology, Disease Outbreak, Coronavirus disease 2019, Outbreak, Betacoronavirus, COVID-19, Coronavirus Infections, Disease Outbreaks, Hospitals, Humans, Pandemics, Pneumonia, Viral, Regression Analysis, SARS-CoV-2, Surveys and Questionnaires, Urologic Diseases, Urology, 030220 oncology & carcinogenesis, Urologic disease, medicine.symptom, viral, Human, medicine.medical_specialty, Regression Analysi, 03 medical and health sciences, Hospital, Ambulatory care, medicine, pneumonia, Renal colic, Original Paper, Betacoronaviru, business.industry, Urinary retention, Coronavirus Infection, medicine.disease, Clinical trial, Settore MED/24, Emergency medicine, business
Abstract

Purpose: The coronavirus disease 2019 (COVID-19) pandemic has put a substantial burden on the Italian healthcare system, resulting in the restructuring of hospitals to care for COVID-19 patients. However, this has likely impacted access to care for patients experiencing other conditions. We aimed to quantify the impact of COVID-19 on access to care for patients with urgent/emergent urological conditions throughout Italy. Materials and Methods: A questionnaire was sent to 33 urological units in the AGILE consortium, asking clinicians to report on the number of urgent/emergent urological patients seen and/or undergoing surgery over a 3-week period during the peak of the COVID-19 outbreak and a reference week prior to the outbreak. ANOVA and linear regression models were used to quantify these changes. Results: Data from 27 urological centres in Italy showed a decrease from 956 patients/week seen just prior to the outbreak to 291 patients/week seen by the end of the study period. There was a difference in the number of patients with urgent/emergent urological disease seen within/during the different weeks (all p values < 0.05). A significant decrease in the number of patients presenting with haematuria, urinary retention, urinary tract infection, scrotal pain, renal colic, or trauma and urgent/emergent cases that required surgery was reported (all p values < 0.05). Conclusion: In Italy, during the COVID-19 outbreak there has been a decrease in patients seeking help for urgent/emergent urological conditions. Restructuring of hospitals and clinics is mandatory to cope with the COVID-19 pandemic; however, the healthcare system should continue to provide adequate levels of care also to patients with other conditions.

Published
2020

10. The syndrome of polymicrogyria, thalamic hypoplasia, and epilepsy with CSWS

Author

Javier Salas-Puig, Laura Grisotto, Anna Rita Ferrari, Elena Parrini, Carmen Barba, Annio Posar, Antonia Parmeggiani, Melania Falchi, Mirco Cosottini, Renzo Guerrini, Francesco Zellini, Giovanni Ambrosetto, Margherita Santucci, Emanuele Bartolini, Bartolini, E, Falchi, M, Zellini, F, Parrini, E, Grisotto, L, Cosottini, M, Posar, A, Parmeggiani, A, Ambrosetto, G, Ferrari, Ar, Santucci, M, Salas-Puig, J, Barba, C, and Guerrini, R.

Subjects
Male, 0301 basic medicine, Pediatrics, medicine.medical_specialty, Early adolescence, Thalamus, Action Potentials, Benign Rolandic Epilepsy, Electroencephalography, antiepileptic drug, benign rolandic epilepsy, confidence interval, continuous spikes and waves during sleep, Rolandic, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, medicine, Polymicrogyria, Humans, Prospective Studies, Child, Child, Preschool, Epilepsy, Rolandic, Female, Follow-Up Studies, Infant, Syndrome, Sleep Stages, Neurology (clinical), Preschool, Prospective cohort study, Thalamic hypoplasia, medicine.diagnostic_test, medicine.disease, 030104 developmental biology, Psychology, 030217 neurology & neurosurgery
Abstract

Objective: We explored the long-term follow-up of continuous spike-and-wave complexes during sleep (CSWS) in polymicrogyria and the anatomic volumetric variables that influence the risk of developing this age-related epileptic encephalopathy. Methods: We performed prospective follow-up of 27 patients with polymicrogyria/CSWS (mean follow-up 14.3 years; range 2–31 years) and comparative volumetric analysis of the polymicrogyric hemispheres and ipsilateral thalami vs 3 subgroups featuring polymicrogyria without CSWS, benign rolandic epilepsy (BRE), and headache. Receiver operator characteristic analysis of the power of volumetric values was determined to predict CSWS. Results: CSWS peaked between 5 and 7 years (mean age at onset 4.7 years). Remission occurred within 2 years from onset in 21%, within 4 years in 50%, and by age 13 years in 100%. We found smaller thalamic and hemispheric volumes in polymicrogyria/CSWS with respect to polymicrogyria without CSWS (p 5 0.0021 for hemispheres; p 5 0.0003 for thalami), BRE, and controls with headache (p , 0.0001). Volumes of the malformed hemispheres and ipsilateral thalami reliably identified the risk of incurring CSWS, with a 68-fold increased risk for values lower than optimal diagnostic cutoffs (436,150 mm3 for malformed hemispheres or 4,616 mm3 for ipsilateral thalami; sensitivity 92.54%; specificity 84.62%). The risk increased by 2% for every 1,000 mm3 reduction of the polymicrogyric hemispheres and by 15% for every 100 mm3 reduction of ipsilateral thalami. Conclusions: The polymicrogyria/CSWS syndrome is likely caused by a cortico-thalamic malformation complex and is characterized by remission of epilepsy within early adolescence. Early assessment of hemispheric and thalamic volumes in children with polymicrogyria and epilepsy can reliably predict CSWS.

Published
2016
Full Text
View/download PDF

11. Flow cytometry and cytomorphology evaluation of hematologic malignancy in cerebrospinal fluids: comparison with retrospective clinical outcome

Author

Giambattista Bertani, Catherine Klersy, Annamaria Nosari, Barbara Scarpati, Claudia Barba, Giovanni Grillo, Clara Cesana, Linda Scampini, Ursula Ferri, Bruno Brando, Enrica Morra, Giuliana Lando, Arianna Gatti, Elisabetta Volpato, Maurizio Faleri, Roberto Cairoli, Cesana, C, Klersy, C, Scarpati, B, Brando, B, Faleri, M, Bertani, G, Gatti, A, Volpato, E, Barba, C, Ferri, U, Scampini, L, Grillo, G, Lando, G, Nosari, A, Morra, E, and Cairoli, R

Subjects
Male, medicine.medical_specialty, Pathology, Hematologic malignancy, Lymphoid neoplasm, Cytodiagnosis, Intrathecal, Gastroenterology, Sensitivity and Specificity, Flow cytometry, Immunophenotyping, Internal medicine, Medicine, Humans, Lymphoid neoplasms, Cytomorphology, Combined method, Cerebrospinal Fluid, Retrospective Studies, Observation time, Hematology, medicine.diagnostic_test, business.industry, General Medicine, Flow Cytometry, Treatment Outcome, Hematologic Neoplasms, Female, business, Clinical evaluation
Abstract

An independent clinical assessment was compared with flow cytometry (FCM) and cytomorphology results obtained on 227 cerebrospinal fluids investigated for hematologic malignancy, in a retrospective longitudinal study with a median observation time of 11 months. A combined method assessment (CMA), defining "positive" a sample if at least one method gave "positive" results, was also tested. Eleven out of 55 screening samples and 53 out of 166 follow-up samples resulted positive at clinical evaluation. FCM and CM were concordant with positive clinical assessment in 68.5% and 51.5% of cases, respectively. According to CMA, 10.5% of samples (resulting false negative by either FCM or cytomorphology) were rescued as true positive. FCM retained significantly higher accuracy than cytomorphology (p = 0.0065) and 100% sensitivity when at least 220 leukocytes were acquired. CMA accuracy was higher than FCM accuracy and significantly higher than cytomorphology accuracy in the analysis of all samples (p < 0.0001), samples from mature B/T cell neoplasms (p = 0.0021), and samples drawn after intrathecal treatment (p = 0.0001). When acquiring ≥220 leukocytes, FCM accuracy was poor, and combining cytomorphology added statistically significant diagnostic advantage (p = 0.0043). Although FCM is the best diagnostic tool for evaluating CSF, morphology seems helpful especially when clinically positive follow-up samples are nearly acellular.

Published
2010

12. Flow cytometry vs cytomorphology for the detection of hematologic malignancy in body cavity fluids

Author

Clara Cesana, Roberto Cairoli, Silvia Cantoni, Claudia Barba, Barbara Scarpati, Ursula Ferri, Maurizio Faleri, Elisabetta Volpato, Enrica Morra, Annamaria Nosari, Giuliana Lando, Linda Scampini, Bruno Brando, Giambattista Bertani, Catherine Klersy, Cesana, C, Klersy, C, Scarpati, B, Brando, B, Volpato, E, Bertani, G, Faleri, M, Nosari, A, Cantoni, S, Ferri, U, Scampini, L, Barba, C, Lando, G, Morra, E, and Cairoli, R

Subjects
Male, Cancer Research, Pathology, medicine.medical_specialty, Hematologic malignancy, Cell Count, Flow cytometry, Immunophenotyping, medicine, Biomarkers, Tumor, Humans, False Positive Reactions, Cytomorphology, Longitudinal Studies, Body cavity, Non-Hodgkin lymphoma, Aged, Retrospective Studies, medicine.diagnostic_test, Serous effusion, business.industry, Hematology, Middle Aged, medicine.disease, Flow Cytometry, Prognosis, Lymphoma, Body Fluids, Serous fluid, Bronchoalveolar lavage, medicine.anatomical_structure, Oncology, Hematologic Neoplasms, Female, business, Bronchoalveolar Lavage Fluid
Abstract

Flow cytometry and cytomorphology results on 92 body cavity fluids [61 effusions and 31 bronchoalveolar lavage fluids (BALF)] from hematologic malignancy were compared with retrospective clinical outcome. We observed double true positive/negative results in 67 cases (73%), and double false negative results in 2 cases (2%). Immunophenotyping accounted for true positive/negative results in 22 out of 23 mismatched cases (25%), and retained significantly higher accuracy than that of cytomorphology especially in effusions and differentiated lymphoma. In BALF analysis, immunophenotyping and cytomorphology sensitivity was 75% and 0%, respectively. Flow cytometry retains the highest accuracy in detecting neoplastic cells in body cavity fluids.

Published
2009

13. Flow cytometric examination of non-hematic body fluids in hematologic malignancies: A comparison with cytology

Author

Roberto Cairoli, Pierluigi Oreste, Enrica Morra, Linda Scampini, Ursula Ferri, Claudia Barba, Bruno Brando, Silvio Veronese, Annamaria Nosari, Barbara Scarpati, Clara Cesana, Cesana, C, Scarpati, B, Brando, B, Barba, C, Ferri, U, Scampini, L, Oreste, P, Veronese, S, Nosari, A, Morra, E, and Cairoli, R

Subjects
Pathology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Immunology, Lymphoblastic lymphoma, Becton dickinson, Follicular lymphoma, Cell Biology, Hematology, medicine.disease, Biochemistry, Flow cytometry, Leukemia, medicine.anatomical_structure, Immunophenotyping, hemic and lymphatic diseases, Acute myelomonocytic leukemia, medicine, Bone marrow, business
Abstract

Introduction: Flow cytometry is well known to detect malignant cells in peripheral blood and bone marrow of patients with hematologic malignancies. However, its role in evaluating non-hematic body fluid contamination by tumor cells is largely unexplored. Patients and Methods: Data detected by flow cytometry in non-hematic body fluid samples drawn between 2002 and 2007 from patients with hematologic neoplasms were retrospectively compared with morphological findings obtained from cytospin slides. Immunophenotyping was carried out by using disease-specific multicolor panels of quadruple monoclonal antibodies, conjugated with the fluorochromes FITC, PE, PerCP, and APC, respectively. Acquisition of information on 1x104 to 1x105 stained cells depending on the whole sample cellularity was assessed on a dual-laser FACSCalibur flow cytometer using the CellQUEST software (Becton Dickinson, San José, CA, USA). Results: Fourty-five samples (bronchoalveolar fluid, n=5; ascites, n=2; hydrocele, n=2; pleural effusion, n=8; and cerebrospinal fluid, n=28) from 32 patients were available for comparison. Diagnoses were as follows: chronic myelomonocitic leukemia (n=1), acute promyelocytic leukaemia (n=2), acute myelomonocytic leukaemia (n=1), B-chronic lymphocitic leukemia (n=4), follicular lymphoma (n=1), acute lymphoblastic leukaemia (n=6), lymphoblastic lymphoma (n=1), high grade non-Hodgkin’s lymphoma (NHL), Burkitt-like (n=3), diffuse large B-cell NHL (n=6), peripheral T-cell NHL (n=3), and NHL, unspecified (n=4). Flow cytometry detected neoplastic cells in 24 cases. Of these cases, only 17 were positive also by morphology. In 7 cases, in which tumor cells were detected by flow cytometry but not by morphology, clinical data confirmed the presence of the disease. Flow cytometry did not show neoplastic cells in 21 cases. Of these cases, only 18 were negative also by morphology. In the remaining 3, the suggestion of diffuse large B-cell NHL contamination by morphology was not confirmed by flow cytometry, demonstrating T-reactive lymphocytes that were clearly negative for disease-specific markers. Conclusions: Our data suggest that flow cytometry is a useful tool complementary to morphology for the screening of non-hematic body fluid contamination in patients with hematologic neoplasms.

Published
2007

14. Temporal lobe epilepsy surgery in children and adults: A multicenter study

Author

Barba, Carmen, Cossu, Massimo, Guerrini, Renzo, Di Gennaro, Giancarlo, Villani, Flavio, De Palma, Luca, Grisotto, Laura, Consales, Alessandro, Battaglia, Domenica, Zamponi, Nelia, d’Orio, Piergiorgio, Revay, Martina, Rizzi, Michele, Casciato, Sara, Esposito, Vincenzo, Quarato, Pier Paolo, Di Giacomo, Roberta, Didato, Giuseppe, Pastori, Chiara, Pavia, Giusy Carfi, Pellacani, Simona, Matta, Giulia, Pacetti, Mattia, Tamburrini, Gianpiero, Cesaroni, Elisabetta, Colicchio, Gabriella, Vatti, Giampaolo, Asioli, Sofia, Caulo, Massimo, Marras, Carlo Efisio, Tassi, Laura, D’Aniello, Alfredo, Morace, Roberta, De Curtis, Marco, Deleo, Francesca, Giordano, Flavio, De Benedictis, Alessandro, Prato, Giulia, Perulli, Marco, Barba C., Cossu M., Guerrini R., Di Gennaro G., Villani F., De Palma L., Grisotto L., Consales A., Battaglia D., Zamponi N., d'Orio P., Revay M., Rizzi M., Casciato S., Esposito V., Quarato P.P., Di Giacomo R., Didato G., Pastori C., Carfi Pavia G., Pellacani S., Matta G., Pacetti M., Tamburrini G., Cesaroni E., Colicchio G., Vatti G., Asioli S., Caulo M., Marras C.E., and Tassi L.

Subjects
0301 basic medicine, Male, Electroencephalography, Neuropsychological Tests, Hippocampus, Neurosurgical Procedures, Epilepsy, 0302 clinical medicine, Postoperative Complications, Cognition, Epilepsy surgery, Child, seizure outcome, medicine.diagnostic_test, Age Factors, Prognosis, Temporal Lobe, Malformations of Cortical Development, Neurology, Child, Preschool, epilepsy surgery, Anticonvulsants, Female, Adult, medicine.medical_specialty, Referral, Adolescent, Temporal lobe, 03 medical and health sciences, Young Adult, Settore MED/39 - NEUROPSICHIATRIA INFANTILE, children, Internal medicine, Early Medical Intervention, medicine, Humans, Preschool, Retrospective Studies, Hippocampal sclerosis, Sclerosis, business.industry, Magnetic resonance imaging, Odds ratio, cognitive outcome, medicine.disease, 030104 developmental biology, Epilepsy, Temporal Lobe, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Objective: To assess seizure and cognitive outcomes and their predictors in children (

Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results