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Purpose: Size and density measurements of the ablation zones on contrast-enhanced computed tomography (CT) after radiofrequency ablation (RFA) of hepatic metastases of primary breast or colorectal cancer were acquired over time. Materials and Methods: Twenty-five liver metastases [colorectal cancer (CRC): n = 16; mean size: 19.6 ± 8.5 mm; breast cancer (BC): n = 9; 27.9 ± 13.6 mm] in 15 patients (CRC: n = 11; age: 65.4 ± 6.5 years; BC: n = 4; 62.0 ± 13.8 years) treated by RFA were included in this retrospective study. All patients had undergone postinterventional serial follow-up using multidetector CT (MDCT) (1 day/1/4/7/10/14/18/23/>24 months) without evidence of local tumor recurrence during the follow-up. The ablation zones were evaluated using a commercial software tool (Syngo CT Oncology) in order to determine volumetric, RECIST-, WHO- and density changes over the course of time. Results were compared by applying repeated measures analysis of variance and displayed graphically. Results: The RF ablation zones demonstrated significant shrinkage (P ≤ 0.05) over the first 7 months (volume, RECIST, WHO) of the follow-up. Follow-up after 7 months did not show any significant changes in size (P > 0.05) (mean volume (ml): 55.2/34.7/26.3/16.5/12.7/10.0/8.9/8.1/7.5; RECIST (mm): 58.7/49.3/43.7/37.8/34.2/31.3/29.1/27.3/24.8; WHO (mm2): 2458.3/1769.3/1341.8/1027.1/870.1/720.2/649.0/570.4/511.3). Mean density values decreased significantly between 1 day (58.9 HU) and 1 month (47.5 HU) after the procedure. Conclusion: Typical changes in size and density values of RF-induced, recurrence-free ablation zones after RFA of hepatic metastases of colorectal and breast cancer were acquired, showing a significant decrease in density of the ablation zone within the first month and significant shrinkage within the first 7 months after RFA.

Web Content Accessibility Guidelines (WCAG) from W3C consist of a set of 65 checkpoints or specifications that Web pages should accomplish in order to be accessible to people with disabilities or using alternative browsers. Many of these 65 checkpoints can only be checked by a human operator, thus implying a very high cost for full evaluation. However, some checkpoints can be automatically evaluated, thus spotting accessibility barriers in a very effective manner. Well known tools like Bobby, Tawdis or WebXACT evaluate Web accessibility by using a mixture of automated, manual and semiautomated evaluations. However, the automation degree of these Web evaluations is not the same for each of these tools. Since WCAG are not written in a formalized manner, these evaluators may have different “interpretations” of what these rules mean. As a result, different evaluation results might be obtained for a single page depending on which evaluation tool is being used.Taking into account that a fully automated Web accessibility evaluation is not feasible because of the nature of WCAG, this paper evaluates the WCAG automation coverage of some well known Web accessibility evaluation tools spotting their weaknesses and differences. We also provide a formalized specification for those checkpoints where these differences have been detected, thus challenging nowaday's tools for more automated coverage.

Describing test results in a standardized format facilitates the exchange of information between different types of tools that are used to evaluate Web sites for accessibility. The Evaluation and Report Language (EARL) is a machine-readable, platform-independent, and vendor-neutral format that builds on Semantic Web technologies to provide a powerful data model for expressing test results. While the primary motivation for developing this language is to facilitate the automation of Web accessibility evaluations, it is has been designed so that it can serve generic Web quality assurance purposes as well as other use cases outside the scope of Web site evaluation.

The purpose of this study was to investigate differences in change of size and CT value between local recurrences and tumor-free areas after CT-guided radiofrequency ablation (RFA) of hepatic metastases during follow-up by means of dedicated software for automatic evaluation of hepatic lesions. Thirty-two patients with 54 liver metastases from breast or colorectal cancer underwent triphasic contrast-enhanced multidetector-row computed tomography (MDCT) to evaluate hepatic metastatic spread and localization before CT-guided RFA and for follow-up after intervention. Sixteen of these patients (65.1 + or - 10.3 years) with 30 metastases stayed tumor-free (group 1), while the other group (n = 16 with 24 metastases; 62.0 + or - 13.8 years) suffered from local recurrent disease (group 2). Applying an automated software tool (SyngoCT Oncology; Siemens Healthcare, Forchheim, Germany), size parameters (volume, RECIST, WHO) and attenuation were measured within the lesions before, 1 day after, and 28 days after RFA treatment. The natural logarithm (ln) of the quotient of the volume 1 day versus 28 days after RFA treament was computed: lnQ1//28/0(volume). Analogously, ln ratios of RECIST, WHO, and attenuation were computed and statistically evaluated by repeated-measures ANOVA. One lesion in group 2 was excluded from further evaluation due to automated missegmentation. Statistically significant differences between the two groups were observed with respect to initial volume, RECIST, and WHO (p

The Web has been growing in size and complexity and is used for the most diverse activities in our everyday life, becoming almost indispensable. Besides, Web applications are becoming more popular, and consequently used by a wide range of people. Thus, it is important to evaluate the accessibility of those applications to guarantee that everyone can access the information. Currently, there are some tools to evaluate the accessibility of classical Web pages, which use WCAG guidelines. However, Web applications impose different challenges, so it is mandatory to find a way to automatically obtain the dynamically introduced HTML code, in order to evaluate what users really experience. This paper details a new process of accessibility evaluation of Web applications, which evaluates the content by triggering possible events that partially change the Web page. It also presents an experimental study with several Web applications, demonstrating the potential of this framework in evaluating Web applications.