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Introduction: Demographic studies of a disease can reveal the characteristics of that disease among a specific population and will help the physicians to achieve a more accurate perception about it.The demographic of Lichen PlanoPilaris (LPP) among the Iranian population is unknown. The aim of this study is to describe the clinical, demographic, and histopathologic findings of lichen planopilaris in the Iranian population.Materials and Methods: In this cross-sectional study, all the patients with Lichen planopilaris were referred to the dermatology clinic of Imam Khomeini hospital from 2013 to 2015. Lichen planopilaris can be diagnosed by collecting histological evidence, dermatological examination, and clinical diagnosis. Their demographic characteristics, drug histories, onset of disease, and family histories were obtained by written questionnaire. Additionally, this study employed SPSS v.20 as the statistical analysis software.Results: One hundred patients were enrolled in this study. With an average age of 47.11 years, 78% of the patients were female, and 50 of these were housewives. The patients included were often from Tehran with Fars ethnicity. Among these patients, 7 had alopecia areata skin disease, and 10 of them suffered from thyroid disease. Most of the histopathology samples collected from these biopsies revealed degeneration of the basal layer of the follicular structure, perifollicular fibrosis, inflammatory cells, and atrophy of the pilosebaceous structures.Conclusion: Both the age spectrum and the disease distribution of LPP among the Iranian population were very diverse when compared to previous studies. Moreover, this study helps the physicians to have a brighter vision about the main reason and cause of LPP spread among diverse Iranian Ethnicities.

A 3D ultrasound computer tomography (USCT) device with a nearly isotropic and spatially invariant 3D point spread function has been constructed at Institute for Data Processing and Electronic (IPE), Karlsruhe Institute of Technology (KIT). This device is currently applied in clinical studies for breast cancer screening. In this paper, a new method to develop an automated segmentation algorithm for USCT acquired images is proposed. The method employs distance regularized level set evolutionary (DRLSE) active contours along with surface fitting extrapolation and 3D binary mask generation for fully automatic segmentation outcome. In the first stage of the proposed algorithm, DRLSE is applied to those 3D USCT slice images which contain breast and are less affected by noise and ring artifacts named as Cat2. The DRLSE segmentation results are employed to extrapolate the rest of slice images known as Cat1. To overcome defectively segmented slice images, a 3D binary mask is generated out of USCT attenuation images. The 3D binary mask is multiplied by the DRLSE-based segmentation results to form finally segmented 3D USCT images. The method was tested on 12 clinical dataset images. According to F-measure criterion, the proposed method shows higher performance than the previously proposed semiautomatic segmentation one.

Display OmittedThe block diagram of the proposed system. Occasionally certain areas in the retina can be questionable for physicians which can lead to wrong interpretations for patients.A method is proposed that introduces a higher ability of segmentation by employing Skeletonization and a threshold selection based on Fuzzy Entropy.By extracting indices of the human retina properly, physicians will be able to estimate pathological injuries with a higher confidence.The proposed approach is fast and outperforms over other previously competitive techniques.The proposed approach consists of two stages. First of all, the retinal vessels was preprocessed by the HSV space and Wiener Filter. Then, the segmentation level is implemented by using Adaptive Filter that employs optimum threshold based on Fuzzy Entropy and Skeleton algorithm. The analysis of retina blood vessels in clinics indices is one of the most efficient methods employed for diagnosing diseases such as diabetes, hypertension and arthrosclerosis. In this paper, an efficient algorithm is proposed that introduces a higher ability of segmentation by employing Skeletonization and a threshold selection based on Fuzzy Entropy. In the first step, the blurring noises caused by hand shakings during ophthalmoscopy and color photography imageries are removed by a designed Wieners filter. Then, in the second step, a basic extraction of the blood vessels from the retina based on an adaptive filtering is obtained. At the last step of the proposed method, an optimal threshold for discriminating main vessels of the retina from other parts of the tissue is achieved by employing fuzzy entropy. Finally, an assessment procedure based on four different measurement techniques in the terms of retinal fundus colors is established and applied to DRIVE and STARE database images. Due to the evaluation comparative results, the proposed extraction of retina blood vessels enables specialists to determine the progression stage of potential diseases, more accurate and in real-time mode.

Automatic grading systems based on histopathological slide images are applied to various types of cancers. To date, cancer scientists and researchers have conducted many experiments to find and evaluate new and innovative automatic cancer grading systems to accelerate their therapeutic diagnoses and ultimately to enable more efficient prognoses. The previously proposed automatic or computer-aided systems for breast cancer grading, including specializing mitosis counting, suffer from various shortcomings. The most important one is their low efficiency along with high complexity due to the huge amount of features. In this paper, three types of features with more flexibility and less complexity are employed. These features are: completed local binary pattern (CLBP) as textural features, statistical moment entropy (SME) and stiffness matrix (SM) as a mathematical model which includes geometric, morphometric and shape-based features. In the proposed automatic mitosis detection method, these three types of features are fused with each other. The SM feature comprises of characteristics which are to be extracted for reliable discrimination of mitosis objects from non-mitosis ones. The evaluations are applied over histology datasets A and H provided by the Mitos-ICPR2012 contest sponsors. Employing both a nonlinear radial basis function (RBF) kernel for support vector machine (SVM) and also random forest classifiers, leads to the best efficiencies among the other competitive methods which have been proposed in the past. The results are in the form of F-measure criterion which is a basis for bioinformatics assessments and evaluation.

This paper introduces a computer-assisted diagnosis (CAD) system for automatic mitosis detection from breast cancer histopathology slide images. In this system, a new approach for reducing the number of false positives is proposed based on Teaching-Learning-Based optimization (TLBO). The proposed CAD system is implemented on the histopathology slide images acquired by Aperio XT scanner (scanner A). In TLBO algorithm, the number of false positives (falsely detected nonmitosis candidates as mitosis ones) is defined as a cost function and, by minimizing it, many of nonmitosis candidates will be removed. Then some color and texture (textural) features such as those derived from cooccurrence and run-length matrices are extracted from the remaining candidates and finally mitotic cells are classified using a specific support vector machine (SVM) classifier. The simulation results have proven the claims about the high performance and efficiency of the proposed CAD system.

Study of histopathological cancerous tissue is one of the most reliable ways to grade various types of cancers. The result of grading helps the physicians to diagnose and prescribe suitable prognosis. The focus of this paper is on a CAD for automatic analysis of breast cancer histopathological Images to count mitosis as an important criteria for the breast cancer grading. To achieve this aim, sets of specific digital histopathological data are used which are captured by particular microscopic scanners named as Aperio XT and Hamamatsu NanoZoomer scanners. In the proposed method, these acquired images are employed and processed based on digital image processing approaches like 2-D anisotropic diffusion as a pre-process and morphological process. For extraction of pixel-wise features from predetermined mitotic regions, an statistical approach based on color information such as maximum likelihood estimation is employed. To prevent misclassification of mitosis and non-mitosis objects, an object-wise completed local binary pattern (CLBP) is proposed to extract texture features robust against rotation and color-level changes, and finally support vector machine (SVM) is used to classify the extracted feature vectors. Having computed the evaluation criteria, our proposed method performs better f-measure (70.94% for Aperio XT scanner images and 70.11% for Hamamatsu images) among the methods proposed by other participants at ICPR2012 Mitosis detection in breast cancer histopathological images.