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The most common cause of hypercalcemia and high plasma PTH levels is primary hyperparathyroidism (PHPT). Clinical features are associated with recurrent urolithiasis and osteoporosis. However, most of the patients are generally asymptomatic or have nonspecific complaints. Biochemical diagnosis is based on elevated plasma calcium and parathormone levels and high 24-h urine calcium excretion. The definitive treatment of PHPT is performing parathyroidectomy after the localization of parathyroid adenoma. In patients who are ineligible for surgery (due to comorbidities or surgical risk), management of hypercalcemia can be very challenging, and several medical agents such as bisphosphonates, calcitonin, or cinacalcet are being applied periodically to control high plasma calcium levels. Radiofrequency ablation is a minimally invasive ablation method which is generally used in the management of benign thyroid nodules for volume reduction and improvement of associated symptoms. Lately, this method has also been used in the management of PHPT patients when surgery is not eligible either because of contraindication due to high surgical risk or patient refusal. We hereby present our experience with radiofrequency ablation therapy in the management of hyperparathyroidism in a 59-year-old female patient.