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Introduction: Rural, remote, and Indigenous stroke patients have worse stroke outcomes than urban Australians. This may be due to lack of timely access to expert facilities. Objectives: We aimed to describe the characteristics of patients who underwent aeromedical retrieval for stroke, estimate transfer times, and investigate if flight paths corresponded with the locations of stroke units (SUs) throughout Australia. Methods: Prospective review of routinely collected Royal Flying Doctor Service (RFDS) data. Patients who underwent an RFDS aeromedical retrieval for stroke, July 2014–June 2018 (ICD-10 codes: I60–I69), were included. To define the locations of SUs throughout Australia, we accessed data from the 2017 National Stroke Audit. The main outcome measures included determining the characteristics of patients with an in-flight diagnosis of stroke, their subsequent pickup and transfer locations, and corresponding SU and imaging capacity. Results: The RFDS conducted 1,773 stroke aeromedical retrievals, consisting of 1,028 (58%) male and 1,481 (83.5%) non-Indigenous and 292 (16.5%) Indigenous patients. Indigenous patients were a decade younger, 56.0 (interquartile range [IQR] 45.0–64.0), than non-Indigenous patients, 66.0 (IQR 54.0–76.0). The most common diagnosis was “stroke not specified,” reflecting retrieval locations without imaging capability. The estimated median time for aeromedical retrieval was 238 min (95% confidence interval: 231–244). Patients were more likely to be transferred to an area with SU and imaging capability (both p < 0.0001). Conclusion: Stroke patients living in rural areas were younger than those living in major cities (75 years, Stroke Audit Data), with aeromedically retrieved Indigenous patients being a decade younger than non-Indigenous patients. The current transfer times are largely outside the time windows for reperfusion methods. Future research should aim to facilitate more timely diagnosis and treatment of stroke.

Summary: Background: We aimed to determine whether heart, stroke, and vascular disease (HSVD) prevalence and emergency primary evacuation (EPE), hospitalisation, and mortality differ by patient characteristics. Methods: An Australian-wide incidence population based study, with prospective data collected form the 1 July 2019 to the 30 October 2020. Findings: Indigenous Australians reported significantly higher prevalence of HSVD at 229.0 per-1000 as compared to 152.0 per-1000 non-Indigenous Australians: risk ratio 1.5 (95% CI 1.2-1.8). 583 remote patients received an EPE for HSVD, consisting of 388 (66.6%; 95% CI: 62.6-70.4) males and 195 (33.0%; 95% CI: 29.6-37.4) females. There were 289 (49.6%; 95% CI 45.4- 53.7) patients who identified as Indigenous, and 294 (50.4%; 95% CI 46.3- 54.6) as non-Indigenous. The mean Indigenous age during EPE was 48.0 (95% CI 45.9-50.1) years old, significantly lower than the non-Indigenous mean age of 55.6 (95% CI 53.8-57.4). Indigenous patients hospitalised for HSVD were younger, the majority younger than 65 years (n=21175; 73.7% 95% CI 73.2-74.2) as compared to non-Indigenous patients (n= 357654; 33.1% 95% CI 33.0-33.15). When adjusted for HSVD prevalence, remote Indigenous patients had a higher hospitalisation rate as compared to non-remote Indigenous patients (rate ratio: 1.6; 95% CI 1.3-2.0) and remote non-Indigenous patients (rate ratio: 1.2; 95% CI 1.0-1.5). More Indigenous patients died of HSVD before the age of 65 years (n=1875; 56.5% 95% CI 54.8-58.2) as compared to non-Indigenous patients (n= 16161; 10.6% 95% CI 10.45-10.8). Interpretation: Indigenous Australians have a higher prevalence, and younger age during EPE, and hospitalisation for HSVD than non-Indigenous Australians. Funding: This is a self/internally-funded study, with the lead organisation being the Royal Flying Doctor Service (RFDS) of Australia. For the duration of the study period, the RFDS provided in-kind support including one full-time equivalent (FTE) and resources (office space, computer, research software, and office equipment). There was no external funding source that had a role in study design or data analysis or interpretation.

Background and Aims: Despite known Indigenous health and socioeconomic disadvantage in countries with a Very High Human Development Index, data on the incidence of stroke in these populations are sparse. With oversight from an Indigenous Advisory Board, we will undertake a systematic review of the incidence of stroke in Indigenous populations of developed countries or regions, with comparisons between Indigenous and non-Indigenous populations of the same region, though not between different Indigenous populations.Methods: Using PubMed, OVID-EMBASE, and Global Health databases, we will examine population-based incidence studies of stroke in Indigenous adult populations of developed countries published 1990-current, without language restriction. Non-peer-reviewed sources, studies including Results: Primary outcomes include crude, age-specific and/or age-standardized incidence of stroke. Secondary outcomes include overall stroke rates, incidence rate ratio and case-fatality. Results will be synthesized in figures and tables, describing data sources, populations, methodology, and findings. Within-population meta-analysis will be performed if, and where, methodologically sound and comparable studies allow this.Conclusion: We will undertake the first systematic review assessing disparities in stroke incidence in Indigenous populations of developed countries. Data outputs will be disseminated to relevant Indigenous stakeholders to inform public health and policy research.

Acute stroke is one of the most common causes of disability worldwide and numbers are projected to increase. Modern and successful recanalizing treatments are available, but timely access to these treatments is most often restricted to urban populations. This disparity affects nearly half of the world’s population, particularly those living in rural and remote areas, and most often affects people with indigenous background. We provide information on this disparity in acute stroke care between rural, remote, and urban areas. We discuss potential new management strategies which could facilitate the timely delivery of acute stroke care to those residents beyond the better serviced urban areas. We focus on the concept of a mobile stroke unit (MSU), especially an Air-MSU. This aircraft solution could provide an imaging capability and immediate clinical expertise via linked telemedicine to diagnose and treat acute stroke patients at the emergency site. The Air-MSU is not only envisioned to allow intravenous thrombolysis in the field but also to allow pre-hospital triage to comprehensive stroke centres through use of contrast imaging to diagnose large vessel occlusion, facilitating endovascular thrombectomy. Moreover, issues regarding optimal operating environment as well as novel imaging and diagnostic devices, which could facilitate the implementation of an Air-MSU are discussed. Innovative health care solutions are urgently needed to close the treatment gap for stroke patients living in rural and remote regions worldwide.

BACKGROUND: Cardiovascular disease is the most common cause of death and disability in Indigenous communities but limited prospective data exists about stroke. AIM: To estimate the difference in stroke recognition, risk factors, treatment rates and outcomes between Indigenous and non-Indigenous peoples admitted to the Wagga Wagga Rural Referral Hospital (WWRRH) over a 5-year period with a suspected acute stroke. METHODS: All suspected strokes presenting to the 33 peripheral hospitals within the Murrumbidgee local health district (MLHD) were transferred to the WWRRH and prospectively assessed over a 5-year period from 01/01/2012 to 31/12/2017. Actions at stroke onset, risks factors, stroke type, treatment and outcomes were analysed. RESULTS: 1843 patients were included. Of these, 45 patients (2.5%) were Indigenous. Only 26.6% of Indigenous and 34% of non-Indigenous patients knew of the fast acronym. Indigenous patients were younger (mean age 62.0 years versus 74.4 years) and more likely to have diabetes (RD 22.3% [95% CI: 3%,41.7%]), dyslipidaemia (RD 19.4% [95% CI: 21.%, 36.7%]), and be ever smokers (RD 24.9% [95% CI: 9.5%,40.3%]). Stroke types were similar except lacunar infarcts were more common (19.2% versus 8.4%). Treatment rates and outcomes were similar between the two groups. CONCLUSIONS: Indigenous Australians with stroke are a decade younger and have a higher prevalence of important, modifiable stroke risk factors. Delayed presentation to hospital is more common, due in part to stroke symptoms being under recognized. When admitted to a specialized stroke unit, treatment rates and outcomes are comparable. This article is protected by copyright. All rights reserved.

Objectives To provide clinical validation of a recent 2D SENSE-based accelerated cardiovascular magnetic resonance (CMR) sequence (accelerated k-t SENSE), investigating whether this technique accurately quantifies left ventricle (LV) volumes, function, and mass as compared to 2D cine steady-state free precession (2D-SSFP). Methods Healthy volunteers (n = 16) and consecutive heart failure patients (n = 26) were scanned using a 1.5 T MRI system. Two LV short axis (SA) stacks were acquired: (1) accelerated k-t SENSE (5–6 breath-holds; temporal/spatial resolution: 37 ms/1.82 × 1.87 mm; acceleration factor = 4) and (2) standard 2D-SSFP (10–12 breath-holds; temporal/spatial resolution: 49 ms/1.67 × 1.87 mm, parallel imaging). Ascending aorta phase-contrast was performed on all volunteers as a reference to compare LV stroke volumes (LVSV) and validate the sequences. An image quality score for SA images was used, with lower scores indicating better quality (from 0 to 18). Results There was a high agreement between accelerated k-t SENSE and 2D-SSFP for LV measurements: bias (limits of agreement) of 2.4% (− 5.4% to 10.1%), 6.9 mL/m2 (− 4.7 to 18.6 mL/m2), − 1.5 (− 8.3 to 5.2 mL/m2), and − 0.2 g/m2 (− 11.9 to 12.3 g/m2) for LV ejection fraction, end-diastolic volume index, end-systolic volume index, and mass index, respectively. LVSV by accelerated k-t SENSE presented good agreement with aortic flow. Interobserver and intraobserver variabilities for all LV parameters were also high. Conclusion The accelerated k-t SENSE CMR sequence is clinically feasible and accurately quantifies LV volumes, function, and mass, with short acquisition time and good image quality.

In clinical practice, cardiac magnetic resonance imaging (CMR) is considered the gold-standard imaging modality for the evaluation of function and structure of the left ventricle (LV). However, the quantification of LV parameters in all frames, even when performed by experienced radiologists, is very time consuming mainly due to the inhomogeneity of cardiac structures within each image, the variability of the cardiac structures across subjects and the complicated global/regional temporal deformation of the myocardium during the cardiac cycle. In this work, we employed a combination of two convolutional neural networks (CNN) to develop a fully automatic LV segmentation method for Short Axis CMR datasets. The first CNN defines the region of interest (ROI) of the cardiac chambers based on You Only Look Once (YOLO) network. The output of YOLO net is used to filter the image and feed the second CNN, based on UNet network, which segments the myocardium and the blood pool. The method was validated in CMR exams of 59 individuals from an institutional clinical protocol. Segmentation results, evaluated by metrics Percentage of Good Contours, Dice Index and Average Perpendicular distance, were 98,59% ± 4,28%, 0,93 ± 0,06 and 0,72 mm ± 0,62 mm, respectively, for the LV epicardium, and 94,98% ± 14,04%, 0,86 ± 0,13 and 1,19 mm ± 1,29 mm, respectively, for the LV endocardium. The combination of two CNNs demonstrated good performance in terms of the evaluated metrics when compared to literature results.

SummaryVestibular system is the absolute referential for the maintenance of balance. Functional deficit with aging can result in balance disturbance and in increase of likelihood of falls.AimTo verify whether specific therapeutic approach of the system can promote motor learning and can contribute to the improvement of balance and to decrease of likelihood of falls.Study designClinical prospective.Material and MethodFifteen women, aged 60 to 69, mean = 64.8 years old (±2.95), resident in Barra Mansa-RJ, were submitted to Cawthorne and Cooksey exercises during three months, three times a week, during sixty minutes. They were evaluated with Berg Balance Scale (BBS), whose scores determine the possibility of fall (PQ).ResultsComparing the data obtained before and after intervention, we observed significant difference (p < 0.05), showing improvement in BBS scores and decrease in PF.ConclusionCawthorne and Cooksey exercises were able to promote significant improvement in the balance of this sample and they can be applied as prevention and treatment in balance disturbances in elderly people.

Steinert's disease is an intrinsic disorder of the muscle with multisystem manifestations. Myotonia may affect any muscle group, is elicited by several factors and drugs used in general anesthesia like hypnotics, sedatives and opioids. Although some authors recommend the use of regional anesthesia or combined anesthesia with low doses of opioids, the safest anesthetic technique still has to be established.We performed a continuous spinal anesthesia in a patient with Steinert's disease undergoing laparoscopic cholecystectomy using 10 mg of bupivacaine 0.5% and provided ventilatory support in the perioperative period. Continuous spinal anesthesia was safely used in Steinert's disease patients but is not described for laparoscopic cholecystectomy. We reported a continuous spinal anesthesia as an appropriate technique for laparoscopic cholecystectomy and particularly valuable in Steinert's disease patients. Resumo: A doença de Steinert é uma desordem intrínseca do músculo com manifestações multissistêmicas. A miotonia pode afetar qualquer grupo muscular e é provocada por vários fatores e medicamentos usados em anestesia geral, como hipnóticos, sedativos e opiáceos. Embora alguns autores recomendem o uso de anestesia regional ou anestesia combinada com opiáceos em doses baixas, a técnica anestésica mais segura ainda precisa ser estabelecida.Administramos raquianestesia contínua em um paciente com doença de Steinert submetido à colecistectomia laparoscópica, com 10 mg de bupivacaína a 0,5%, e fornecemos suporte ventilatório no período perioperatório. A raquianestesia contínua foi usada com segurança em pacientes com doença de Steinert, mas não foi relatada em colecistectomia laparoscópica. Relatamos a raquianestesia contínua como uma técnica adequada para a colecistectomia laparoscópica e particularmente valiosa em pacientes com doença de Steinert. Keywords: Continuous spinal anesthesia, Steinert's disease, Laparoscopic cholecystectomy, Palavras-chave: Raquianestesia contínua, Doença de Steinert, Colecistectomia laparoscópica

ResumoA doença de Steinert é uma desordem intrínseca do músculo com manifestações multissistêmicas. A miotonia pode afetar qualquer grupo muscular e é provocada por vários fatores e medicamentos usados em anestesia geral, como hipnóticos, sedativos e opiáceos. Embora alguns autores recomendem o uso de anestesia regional ou anestesia combinada com opiáceos em doses baixas, a técnica anestésica mais segura ainda precisa ser estabelecida.Administramos raquianestesia contínua em um paciente com doença de Steinert submetido à colecistectomia laparoscópica, com 10mg de bupivacaína a 0,5%, e fornecemos suporte ventilatório no período perioperatório. A raquianestesia contínua foi usada com segurança em pacientes com doença de Steinert, mas não foi relatada em colecistectomia laparoscópica. Relatamos a raquianestesia contínua como uma técnica adequada para a colecistectomia laparoscópica e particularmente valiosa em pacientes com doença de Steinert.AbstractSteinert's disease is an intrinsic disorder of the muscle with multisystem manifestations. Myotonia may affect any muscle group, is elicited by several factors and drugs used in general anesthesia like hypnotics, sedatives and opioids. Although some authors recommend the use of regional anesthesia or combined anesthesia with low doses of opioids, the safest anesthetic technique still has to be established.We performed a continuous spinal anesthesia in a patient with Steinert's disease undergoing laparoscopic cholecystectomy using 10 mg of bupivacaine 0.5% and provided ventilatory sup‐port in the perioperative period. Continuous spinal anesthesia was safely used in Steinert's disease patients but is not described for laparoscopic cholecystectomy. We reported a continuous spinal anesthesia as an appropriate technique for laparoscopic cholecystectomy and particularly valuable in Steinert's disease patients.