Search

Your search keyword '"Alfredo Mellano"' showing total 2 results
Start Over Author "Alfredo Mellano" Topic medicine
2 results on '"Alfredo Mellano"'

1. Post-surgery sequelae unrelated to disease progression and chemotherapy revealed in follow-up of patients with stage III colon cancerResearch in context

Author

Alexia Mirandola, Andrei Kudriavtsev, Catalina Isabel Cofre Muñoz, Raquel Comas Navarro, Marco Macagno, Saidi Daoud, Cynthia Sanchez, Brice Pastor, Ekaterina Pisareva, Mireia Sanchis Marin, Javier Gonzalo Ruiz, Alejandro Piris, Ariadna Garcia Rodriguez, Nadia Saoudi Gonzalez, Ana Vivancos, Virginia Quarà, Alfredo Mellano, Felice Borghi, Giorgio Corti, Caterina Marchiò, Anna Sapino, Alice Bartolini, Giovanni Crisafulli, Alberto Bardelli, Massimo Di Maio, Gerald Lossaint, Florence Frayssinoux, Evelyne Crapez, Marc Ychou, Ramon Salazar Soler, Elisabetta Fenocchio, Paula X. Fernandez Calotti, Thibault Mazard, Cristina Santos Vivas, Elena Elez, Federica Di Nicolantonio, and Alain R. Thierry

Subjects
Diagnostic, Tumour biology, Colorectal cancer, Circulating DNA, Neutrophil extracellular traps, Post-surgery, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: We studied the poorly-known dynamics of circulating DNA (cir-nDNA), as monitored prospectively over an extended post-surgery period, in patients with cancer. Methods: On patients with stage III colon cancer (N = 120), using personalised molecular tags we carried out the prospective, multicenter, blinded cohort study of the post-surgery serial analysis of cir-nDNA concentration. 74 patients were included and 357 plasma samples tested. Findings: During post-operative follow-up, the patients’ median cir-nDNA concentration was greater (P 18 months post-surgery, the data suggest that the persistence of NETs formation is not due to the adjuvant CT. Interpretation: (1), Given the inter-patient heterogeneity, the post-surgery cir-nDNA level cannot be considered a reliable value, and caution must be exercised when determining mutation allele frequency or the mutation status; and (2), specific studies must be undertaken to investigate the possible clinical impact of the persistent, low-grade inflammation resulting from elevated NETs levels, such as observed in these post-surgery patients, given that such levels are known to potentially induce adverse cardiovascular or thrombotic events. Funding: This work was supported by the H2020 European ERA-NET grant on Translational Cancer Research (TRANSCAN-2).

Published
2024
Full Text
View/download PDF

2. Implementation of the ERAS (Enhanced Recovery After Surgery) protocol for colorectal cancer surgery in the Piemonte Region with an Audit and Feedback approach: study protocol for a stepped wedge cluster randomised trial: a study of the EASY-NET project

Author

Pagano, E, Pellegrino, L, Rinaldi, F, Palazzo, V, Donati, D, Meineri, M, Palmisano, S, Rolfo, M, Bachini, I, Bertetto, O, Borghi, F, Ciccone, G, ERAS Colon-Rectum Piemonte study group members. ERAS Colon-Rectum Piemonte study group members: Site investigators: Federica Borromeo, Fabio Priora, Sergio Gentilli, Luca Portigliotti, Paolo Massucco, Marco Palisi, Felice Borghi, Luca Pellegrino, Maurizio De Giuli, Aridai Resendiz, Paola Bellomo, Silvia Marola, IRCCS Candiolo Alfredo Mellano, Dario Ribero, Roberto, Polastri, Andrea Muratore, Nicoletta Sveva Pipitone, Garino, Mauro, Ospedale Cardinal Massaia, Asti: Elisabetta Castagna, Pozzo, Gabriele, Ospedale Castelli, Verbania: Andrea Caneparo, Adriana Ginardi, Reggina Lagana, Monica Carrera, Stefania Muzio, Ospedale, Civile, Ivrea: Luca Panier Suffat, Ivan, Lettini, Alberto Kiss, Valentina Gentile, Roberto Saracco, Donatella Scaglione, Andrea Gattolin, Roberto Rimonda, Francesco Battafarano, Luigi Oragano, Luca Lorenzin, Carlo Palenzona, Carmine Gianfranco Di Somma, Eliana Giaminardi, Marco Calgaro, Marco Naddeo, Piero Cumbo, Emma Marchigiano, Francesca, Cravero, Amisano, Marco Francesco, Francesco, Lemut, Tiziana Viora, Luciano Bonaccorsi, Silvio Testa, Clemente De Rosa, Marco, Brunetti, Matteo, Gatti, Carlo Bima, Enrico Gibin, Quaglino, Francesco, Festa, Federico, Luca, Bonatti, Morino, Mario, Allaix, Marco Ettore, Paolo De Paolis, Ida Marina Raciti, Mauro, Santarelli, Gitana, Scozzari, Felice, Borghi, Donati, Danilo, Maurizio, Meineri, Palmisano, Sarah, Pellegrino, Luca, Ciccone, Giovannino, Rosalba, Galletti, Pagano, Eva, Sandrucci, Sergio, Ilaria, Bachini, Anna De Magistris, Barbara, Mitola, Paolo, Massucco, Alessio, Rizzo, Caironi, Pietro, Monica, Rolfo, Anna, Orlando, Bertetto, Oscar, Francesco, Brunetti, Corinna, Defilè, DIAS MARTINS, VITOR HUGO, Lisa, Giacometti, Papurello, Matteo, Fabio, Saccona, and Danila, Turco.

Subjects
medicine.medical_specialty, audit, Audit, Disease cluster, quality in health care, Feedback, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Medicine, Humans, Multicenter Studies as Topic, Duration (project management), Enhanced recovery after surgery, Pandemics, Randomized Controlled Trials as Topic, Protocol (science), business.industry, SARS-CoV-2, Incidence (epidemiology), COVID-19, General Medicine, Length of Stay, Colorectal surgery, Italy, Sample size determination, 030220 oncology & carcinogenesis, Emergency medicine, 030211 gastroenterology & hepatology, Surgery, colorectal surgery, business, Colorectal Neoplasms, Enhanced Recovery After Surgery
Abstract

IntroductionThe ERAS protocol (Enhanced Recovery After Surgery) is a multimodal pathway aimed to reduce surgical stress and to allow a rapid postoperative recovery. Application of the ERAS protocol to colorectal cancer surgery has been limited to a minority of hospitals in Italy. To promote the systematic adoption of ERAS in the entire regional hospital network in Piemonte an Audit and Feedback approach (A&F) has been adopted together with a cluster randomised trial to estimate the true impact of the protocol on a large, unselected population.MethodsA multicentre stepped wedge cluster randomised trial is designed for comparison between standard perioperative management and the management according to the ERAS protocol. The primary outcome is the length of hospital stay (LOS). Secondary outcomes are: incidence of postoperative complications, time to patients’ recovery, control of pain and patients’ satisfaction. With an A&F approach the adherence to the ERAS items is monitored through a dedicated area in the study web site. The study includes 28 surgical centres, stratified by activity volume and randomly divided into four groups. Each group is randomly assigned to a different activation period of the ERAS protocol. There are four activation periods, one every 3 months. However, the planned calendar and the total duration of the study have been extended by 6 months due to the COVID-19 pandemic.The expected sample size of about 2200 patients has a high statistical power (98%) to detect a reduction of LOS of 1 day and to estimate clinically meaningful changes in the other endpoints.Ethics and disseminationThe study protocol has been approved by the Ethical Committee of the coordinating centre and by all participating centres. Study results will be timely circulated within the hospital network and published in peer-reviewed journals.Trial registration numberNCT04037787.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results