1. Effect of the topical Klox fluorescence biomodulation system on the healing of canine surgical wounds
- Author
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Giacomo Rossi, Angela Palumbo Piccionello, Andrea Marchegiani, Cecilia Vullo, Gian Enrico Magi, Riccardo Botto, Alberto Salvaggio, and Adolfo Maria Tambella
- Subjects
medicine.medical_specialty ,040301 veterinary sciences ,Decorin ,medicine.medical_treatment ,Surgical Wound ,Administration, Cutaneous ,Fluorescence ,0403 veterinary science ,03 medical and health sciences ,Dogs ,0302 clinical medicine ,medicine ,Animals ,Immunologic Factors ,Clinical significance ,Prospective Studies ,Saline ,Skin ,Wound Healing ,integumentary system ,General Veterinary ,business.industry ,Histology ,Surgical wound ,04 agricultural and veterinary sciences ,Surgery ,030220 oncology & carcinogenesis ,Orthopedic surgery ,Immunohistochemistry ,business ,Wound healing - Abstract
Objective To determine the effect of the Klox fluorescence biomodulation system (Phovia) on the healing of surgical wounds. Study design Prospective, blinded, controlled clinical trial. Sample population Healthy dogs undergoing orthopedic surgery (n = 10). Methods Half of the length of each surgical wound was treated with Phovia, and the remaining 50% was treated with saline solution on the first day after surgery and every 3 days until day 13. Wound healing of treated and control areas within each wound was evaluated via macroscopic assessment and histological and immunohistochemical analysis of treated and control wounds. Results The areas treated with Phovia achieved lower histology scores (P = .001), consistent with complete re-epithelialization, less inflammation of the dermal layer, and greater and more regular deposition of collagen. According to immunohistochemistry, expression of factor VIII, epidural growth factor, decorin, collagen III, and Ki67 was increased in treated compared with untreated tissues. Conclusion Phovia therapy improved re-epithelialization, decreased dermal inflammation, and improved matrix formation in uncomplicated cutaneous incisional wounds by regulating the expression of key biological mediators. Clinical significance Phovia may be a beneficial adjunct to promote the healing of incisional wounds.
- Published
- 2020