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Background: Despite of the major effort to improve asthma management, there are still poor public knowledge and perception among patients with asthma and their family in the Kingdom of Saudi Arabia. Methods: Across sectional descriptive study was conducted last May 20, 2015 during World Asthma Day at Medical Tower ground floor in King Saud Medical City in Riyadh, Kingdom Saudi Arabia with more than 100 participants in the said activity from different area of Riyadh. Questionnaires were distributed to the participants after given asthma awareness by healthcare providers. Results: A total of 55 participants during Asthma day responded to the questionnaire, Majority are male (50.94%) and Saudi nationality (67.92%). After intervention and awareness given to the participants, most of them are aware that asthma is shortness of breath and coughing (87%) which considered being the major signs and symptoms of asthma. Furthermore they don't believe that abdominal pain causes asthma (25%). Participants are aware that most of the common risk factors of asthma is exposure to smoke (94%) followed by exposure to polluted air (91%). The knowledge and perception of the participants towards the medication needs to be used for asthma, most of them answered ventolin spray (77%) and followed by oxygen (72%). Conclusions: Different model of educational activity for bronchial asthma helps in improving the knowledge and awareness of patients and family about asthma disease.

International audience; Autosomal recessive interleukin (IL)-12 p40 (IL-12p40) deficiency is a rare genetic etiology of Mendelian susceptibility to mycobacterial disease (MSMD). We report the genetic, immunologic, and clinical features of 49 patients from 30 kindreds originating from 5 countries (India, Iran, Pakistan, Saudi Arabia, and Tunisia). There are only 9 different mutant alleles of the IL12B gene: 2 small insertions, 3 small deletions, 2 splice site mutations, and 1 large deletion, each causing a frameshift and leading to a premature stop codon, and 1 nonsense mutation. Four of these 9 variants are recurrent, affecting 25 of the 30 reported kindreds, due to founder effects in specific countries. All patients are homozygous and display complete IL-12p40 deficiency. As a result, the patients lack detectable IL-12p70 and IL-12p40 and have low levels of interferon gamma (IFN-gamma). The clinical features are characterized by childhood onset of bacille Calmette-Guerin (attenuated Mycobacterium bovis strain) (BCG) and Salmonella infections, with recurrences of salmonellosis (36.4%) more common than recurrences of mycobacterial disease (25%). BCG vaccination led to BCG disease in 40 of the 41 patients vaccinated (97.5%). Multiple mycobacterial infections were rare, observed in only 3 patients, whereas the association of salmonellosis and mycobacteriosis was observed in 9 patients. A few other infections were diagnosed, including chronic mucocutaneous candidiasis (n = 3), nocardiosis (n = 2), and klebsiellosis (n = 1). IL-12p40 deficiency has a high but incomplete clinical penetrance, with 33.3% of genetically affected relatives of index cases showing no symptoms. However, the prognosis is poor, with mortality rates of up to 28.6%. Overall, the clinical phenotype of IL-12p40 deficiency closely resembles that of interleukin 12 receptor beta 1 (IL-12R beta 1) deficiency. In conclusion, IL-12p40 deficiency is more common than initially thought and should be considered worldwide in patients with MSMD and other intramacrophagic infectious diseases, salmonellosis in particular. (Medicine 2013; 92: 109-122)